| 单词 | assay |
| 例句 | I assayed to throw up the Sash, that I might longer watch his Progress, who was the great Work of my Hands, but would not lift. The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves 2009-10-13T00:00:00Z How can one assay the total impact of the unprecedented calamity that gave rise to the world we live in? 1491 2005-10-10T00:00:00Z “I do not think it is more than two hours assay,” said the Wart, following up his advantage. The Once and Future King 1958-01-01T00:00:00Z After awakening, he watched Ruben complete the assay—from a distance, for he was radioactive. Big Science 2015-07-07T00:00:00Z “That I do, and we can prove it by assay.” East of Eden 1952-09-01T00:00:00Z Again I assayed a response; this time, there was a low growl, a hideous, rasping gargle in the throat. The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves 2009-10-13T00:00:00Z One day Kamen was summoned to the office of financial fuss- budget Don Cooksey, who instructed him to prepare a detailed requisition for equipment to perform chemical assays—and not to worry about the cost. Big Science 2015-07-07T00:00:00Z Tom said seriously, “If the assay showed enough nickel and silver, wouldn’t it pay to mine it?” East of Eden 1952-09-01T00:00:00Z A sloop’s crew assayed flight in their longboat, but they were overtaken. The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves 2009-10-13T00:00:00Z By the mast pond, where the great spars of ships lay refracted, we saw a little girl with a bucket, a vain and minute assay at extinguishing the flames. The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves 2009-10-13T00:00:00Z If such a haplogroup turned up in Pena’s assays, it could write a new chapter in the early history of Native Americans. 1491 2005-10-10T00:00:00Z But when Montaigne used the word it meant an assay or a test. The Invention of Science 2015-09-17T00:00:00Z I assayed to try my own hand at botis mots, saying to her in the morning, “You are — you are come down to the breakfast room as the — some dew on the flowers. Falling.” The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume I: The Pox Party 2006-09-12T00:00:00Z When Sterling-Duprey reappears onstage with her headlamp, she might be assaying the damage. Review: Awilda Sterling-Duprey Summons Dancing Forces of Nature 2023-03-05T05:00:00Z In light of this information Lederberg, Sagan, and others spurred advanced conceptual and experimental work on microbial and chemical assays that would culminate with the spectacular Viking missions to Mars in 1976. Sputnik’s spawn: How the Cold War created astrobiology 2014-03-09T17:30:00Z This underwatched NBC comedy assays a different political or cultural debate in every episode—and it’s at its best when it’s most willing to lacerate. Here Are the Best TV Shows of 2016 So Far 2016-06-07T04:00:00Z Daniele Gatti, a visionary in Mahler, comes to town in January with his new orchestra, the storied Royal Concertgebouw: They assay the First, an evening that follows a foray into Wagner and Bruckner. What to Look Forward to in the Fall Classical Music Season 2017-09-08T04:00:00Z With her latest album, Barber assays one classic cut from the Great American Songbook after another. Patricia Barber's hot jazz summer starts with her vulnerable version of "All in Love Is Fair" 2021-07-09T04:00:00Z As a sprawling human drama, poised on the precipice of a violence that you know is waiting for its beguilingly drawn and assayed characters, it is a riveting work of art. Review | ‘The Ferryman,’ an explosive, exhilarating human drama 2018-10-21T04:00:00Z Bowie often had the intensity of a lizard assaying a stranger. David Bowie: A Starman Not Just in Music, But in the Movies Too 2016-01-11T05:00:00Z Among the actors assaying the game’s other denizens, Louis E. Davis gives an especially winning account of a player with no apparent love of adventure. ‘She Kills Monsters’: A daring journey into the world of Dungeons & Dragons While there is room for polishing, it looks more finished than the Washington Ballet’s earlier assays of the full-length ballets “Giselle” and “Romeo and Juliet.” Review | The Washington Ballet awakens with a lavish, triumphant ‘Sleeping Beauty’ 2019-03-01T05:00:00Z He decided to assay one last project before giving up. Daniel Clowes?s Retrospective at the Oakland Museum 2012-03-30T13:43:38Z It is the first version of the full-length ballet to be assayed by the Washington Ballet in its 70-year existence. Misty Copeland to make ‘Swan Lake’ debut with Washington Ballet For the upcoming performances, her dancers will assay an updated production of Balanchine’s “Gounod Symphony.” Suzanne Farrell Ballet to disband in 2017 2016-09-21T04:00:00Z Louis has spent the last three years explaining the allure of Marine Le Pen — just recently in this publication — while Vance spent the run-up to the 2016 election assaying the appeal of Donald J. Trump. ‘The End of Eddy’ Captures a Savage Childhood and a Global Movement 2017-05-17T04:00:00Z As it happens, the Replacements—who were dubbed the ’Mats, short for placemats, by their fans—have themselves been assayed in song. Why Rock Criticism Was Essential to the Replacements 2016-05-23T04:00:00Z “I am simply tumescent at the prospect of assaying the beloved character of Ignatius J. Reilly with our team of magnificent and weird artistic champions,” Mr. Offerman said in a statement. Nick Offerman Joins ‘Confederacy of Dunces’ 2015-03-01T05:00:00Z Mind you, Aaron Posner’s drama — in which four actors will take turns portraying Adams, as well as assaying a gamut of others, from George Washington to Abraham Lincoln — has no aspiration to being “Hamilton II.” Alexander Hamilton had his life turned into a musical. Now, John Quincy Adams gets his turn, in a new play. 2019-02-01T05:00:00Z “We said either there’s something wrong with our assay or this patient’s got recurring disease,” said Swanton. DNA-based test can spot cancer recurrence a year before conventional scans 2017-04-26T04:00:00Z Jackman plays a pirate, while Mara, controversially, assays the role of Tiger Lily. The Most Anticipated Movies of 2015 2014-12-31T05:00:00Z Teuscher was to assay her first “Swan Lake” on Sunday afternoon, but she stepped in on short notice Thursday night for an injured Gillian Murphy. A show of virtuosos, ‘Swan Lake’ shimmers with strong women 2017-01-29T05:00:00Z This unpretentious aesthetic is very much in vogue; it was on view at Folger in 2012 in a sleek “Hamlet” from Shakespeare’s Globe that similarly was assayed by a cast of eight. A well-played, compact ‘King Lear’ at Folger Theatre He sent the pebbles to an assay office. Gems Made in the U.S.A. 2022-12-05T05:00:00Z He assayed characters from each of the nominated musicals and finished up in the number, in versatile style, tap dancing in a tuxedo. ‘Dear Evan Hansen’ wins the Tony Award for best musical 2017-06-11T04:00:00Z Most of the critics mentioned a favorite number or two but assayed the full song list as forgettable and failing to enrich the story or characters. ArtsBeat: 'Spider-Man' Turns Off the Critics 2011-02-08T13:42:42Z Frank Greenaway putting the final touches to the reconstruction of a medieval assaying laboratory in the new chemistry galleries in 1964. Frank Greenaway obituary 2013-07-16T16:48:05Z After assaying New York detectives and high-tech skullduggery in 1904’s “The Gates of Chance,” he attempted and then abandoned a drama in blank verse. The 1906 Novel That Imagined Present-Day New York 2015-03-04T05:00:00Z Today, “I just do the basic assays, for pH, total acidity, brix,” she says. Theresa Heredia is fine-tuning the wines in Russian River Valley That’s not surprising, Wu says, noting that scientists use specific assays to calculate levels of the protein in the cells and organisms they work with. Why Does This Hybrid Monkey Glow Green? 2023-11-10T05:00:00Z In a nonanimal assay, the cream made up of the more porous “super melanin” particles proved more effective at mopping up ROS, likely because of the particles’ higher surface area, Gianneschi says. Synthetic ‘super melanin’ speeds skin repair 2023-11-02T04:00:00Z Assessing and testing for pathogens can be problematic, as the authors found when they studied various methods including culture-based assays, immuno-based technologies, and emerging technologies. Contaminants in cannabis and hemp flowers create potential for health risks 2023-10-20T04:00:00Z The authors' findings are supported by experimental protein structures and enzyme assays and hold promise for biotechnological applications in biofuel production. Predator-prey defense mechanisms unlock key to marine biofuel production 2023-10-10T04:00:00Z Her lab and collaborators recently developed a novel assay that assesses the amount of damaged mtDNA in a blood sample. A blood test for Parkinson’s disease? 2023-08-29T04:00:00Z That testing includes a seven-drug assay similar to the urine tests used by many probation departments, as well as a separate test for fentanyl. Mexico says it doesn't have a fentanyl problem. New data reveal a hidden epidemic 2023-07-07T04:00:00Z Currently, smell tests aren’t covered by insurance and don’t even have a code for doctors to use for diagnosis or insurance reimbursement as blood tests or other assays do. Smell-Loss Tests Could Reveal Health Problems 2023-03-28T04:00:00Z Last year, the European Medicines Agency gave its blessing to a commercial assay that offers a simple way for scientists and public health officials to measure T-cell immunity. How immune are we? Why answering this question is essential for post-pandemic life 2023-03-20T04:00:00Z Meeusen says he and his Mayo Clinic colleagues are generally wary of new medical tests, but that the evidence for ceramide testing was compelling enough to start offering the assays to patients in 2016. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z The assay could also help determine who may benefit from an experimental Parkinson’s compound that targets LRRK2. A blood test for Parkinson’s disease? 2023-08-29T04:00:00Z And just like a pregnancy test, he said, the assays show only a positive or negative result. Mexico says it doesn't have a fentanyl problem. New data reveal a hidden epidemic 2023-07-07T04:00:00Z But Congress allows the E.P.A. to monitor for only a limited list of contaminants in the environment, and even with approval, the bureaucratic process of validating and deploying each of the assays could take years. Weeks After Ohio Train Derailment, Health Concerns Mount 2023-03-09T05:00:00Z In time, Guccione said, the test could be used alongside other assays to reveal more about how T cells protect and for how long. How immune are we? Why answering this question is essential for post-pandemic life 2023-03-20T04:00:00Z The reactors would likely be fueled by high assay low enriched uranium, or HALEU, of which Russia is the only producer. Dow and X-energy to build U.S. Gulf Coast nuclear demonstration plant 2023-03-01T05:00:00Z The compound is now in clinical testing and Sanders suggests her team’s assay could indicate whether it is helping patients. A blood test for Parkinson’s disease? 2023-08-29T04:00:00Z The participants had to have first shown symptoms within the past week and to have tested positive in a rapid antigen assay. New COVID Antiviral Cuts Hospitalizations in Half 2023-02-08T05:00:00Z “We are only as good as our assays.” Weeks After Ohio Train Derailment, Health Concerns Mount 2023-03-09T05:00:00Z Lincoln, in other words, was essential, tapped by fate for a specific test — yet the outcome of this assay was not predetermined. Opinion | Rising to a historic destiny, Zelensky embodies America’s values 2022-12-23T05:00:00Z The legislation suggests alternative methods, including using organ chips and cell-based assays. Research gets a boost in final 2023 spending agreement 2022-12-20T05:00:00Z So far, the assay has only been retrospectively tested on stored blood samples; researchers will need to prove it can accurately and sensitively detect Parkinson’s early through a prospective trial. A blood test for Parkinson’s disease? 2023-08-29T04:00:00Z "We still have to assay the characteristics of this bomb, the potential it had," she added. Chile police foil bomb attack in Santiago business district 2022-10-20T04:00:00Z Available screening tests range from stool assays that are typically administered annually to colonoscopies that are performed once every 10 years. Screening procedure fails to prevent colon cancer deaths in large study 2022-10-09T04:00:00Z On the other hand, transformation is often assayed by incorporating an antibiotic-resistance gene in the plasmid to be transferred into the host organism. Biology for AP Courses 2022-06-09T00:00:00Z In biology, the concentration of proteins in a sample can be measured using a chemical assay that changes color depending on how much protein is present. High School Statistics 2020-03-27T00:00:00Z Research tools for drugmakers and diagnostic assays are also part of the agreement. ‘A pretty big deal’: U.S. makes COVID-19 technologies available for use in developing countries 2022-05-12T04:00:00Z As the components of these natural toxins continue to be assayed by evolving technologies, the number of promising molecules is also growing. Deadly Venom From Spiders and Snakes May Also Cure What Ails You 2022-05-03T04:00:00Z But when a supervisor hired an outside company to solve an assay problem that she knew how to fix herself, she decided her tech days had ended. On the hunt for new viruses, this bat-trapping scientist hopes to prevent future pandemics 2022-04-13T04:00:00Z These tests are less invasive, can be processed faster and, in some cases, are more sensitive than nasal-based assays. New COVID Spit Tests May Be More Accurate and Easier Than Nasal Swabs 2022-03-28T04:00:00Z This is called a standard curve for the assay. High School Statistics 2020-03-27T00:00:00Z Researchers would also like to sequence more of the viruses they catch, because standard PCR assays usually can’t distinguish between variants. Pandemic signals from the sewer—what virus levels in wastewater tell us 2022-03-08T05:00:00Z “We can do assays nowadays using only a couple of micrograms of venom that 10 or 15 years ago would have required hundreds of micrograms,” or more, Dr. Fry said. Deadly Venom From Spiders and Snakes May Also Cure What Ails You 2022-05-03T04:00:00Z Wright says that only a mouse assay or a pricey molecular analysis tool operated by the state can definitively confirm that shellfish are truly safe to eat. These Shellfish Could Kill You 2022-01-24T05:00:00Z Centers for Disease Control and Prevention’s policy on how to use antigen tests, says saliva-based PCR assays have very different use cases than those of antigen tests. New COVID Spit Tests May Be More Accurate and Easier Than Nasal Swabs 2022-03-28T04:00:00Z Known as a lateral flow assay, it is the same type of test used to detect the coronavirus at home. At-Home Coronavirus Tests Are Inaccessible to Blind People 2022-01-10T05:00:00Z “For any good assay you need both positive and negative controls,” Williams wrote in an email to the AP. NOT REAL NEWS: A look at what didn’t happen this week 2022-01-07T05:00:00Z Dowd most famously assayed the brutal Aunt Lydia in “The Handmaid’s Tale,” for which she won an Emmy. Why Ann Dowd and Martha Plimpton felt so good when the filming of 'Mass' was done 2021-12-28T05:00:00Z But assaying information — weighing it, analyzing it, separating the gold from the pyrite — still depends on old-fashioned human judgment. Opinion | We’re adapting to living with covid-19 — less so to accepting uncertainty 2021-12-24T05:00:00Z This past week, laboratory assays by several groups have shown antibodies, whether elicited by vaccines or a previous infection, are significantly less effective at neutralizing Omicron than other variants. Scientists see a ‘really, really tough winter’ with Omicron 2021-12-13T05:00:00Z Despite differences in the labs’ results—which are common in such virus neutralisation assays—their conclusions are similar, and show that Omicron’s effects on neutralizing antibodies are “not complete knockouts”, says Murrell. Omicron Is Likely to Weaken COVID Vaccine Protection—But Boosters Could Restore It 2021-12-09T05:00:00Z Few people showed up for weeks of questioning by the prosecution narrowing down the details of “assays,” or blood tests. The Elizabeth Holmes trial is the hottest ticket in Silicon Valley 2021-12-07T05:00:00Z Part of that immune question will be resolved in about two weeks as we get the first neutralization assay results in. How did omicron mutate, and how could it evade antibodies? Fred Hutch scientist Trevor Bedford answers our questions 2021-12-02T05:00:00Z The Centers for Disease Control and Prevention’s assay fell flat. Biohackers at the gate: The untold story of how DIY experimenters waged war on COVID-19 2021-10-15T04:00:00Z Earlier on Wednesday, an F.D.A. analysis questioned a key test used by the company, known as a psVNA assay, saying it may have skewed the findings. Data from Federal Scientists Raise Questions About J.&J. Booster Shots 2021-10-13T04:00:00Z Scientists used two types of laboratory assay to test how well Omicron can evade neutralizing, or virus-blocking, antibodies triggered by vaccination and infection. Omicron Is Likely to Weaken COVID Vaccine Protection—But Boosters Could Restore It 2021-12-09T05:00:00Z A key test used by the company to measure the immune response of a six-month-boost — known as a psVNA assay — was not sensitive enough for the task, the analysis said. People who received J&J vaccine may be better off with Moderna or Pfizer booster, study says 2021-10-13T04:00:00Z These assays correctly identify a SARS-CoV-2 infection in 72 percent of people with symptoms and 58 percent of people without them, according to a review study published in March. The Smartest Way to Use Rapid At-Home COVID Tests 2021-10-12T04:00:00Z This bad assay had been used on patients since September 2013. How Elizabeth Holmes sidelined the real scientists at Theranos 2021-09-24T04:00:00Z “It is likely that the results seen are due to the low sensitivity of the psVNA assay used,” the F.D.A. stated in its report. Data from Federal Scientists Raise Questions About J.&J. Booster Shots 2021-10-13T04:00:00Z Modern technology, such as gene assays and molecular engineering, is enabling scientists to target individual parts of this network, identifying new targets for treating autoimmunity with much more precision. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z “It is likely that the results seen are due to the low sensitivity of the psVNA assay used,” the FDA stated in its report. People who received J&J vaccine may be better off with Moderna or Pfizer booster, study says 2021-10-13T04:00:00Z At-home antigen tests are expected to become more widely available later this autumn: on Wednesday the Biden administration committed to address shortages with the purchase of hundreds of millions of the assays. The Smartest Way to Use Rapid At-Home COVID Tests 2021-10-12T04:00:00Z This bad assay had been used on patients since September 2013. How Elizabeth Holmes sidelined the real scientists at Theranos 2021-09-24T04:00:00Z The data on antibodies only include a few thousand people, he notes, and the assays used to test for antibodies can easily lead to false positives. SARS-like viruses may jump from animals to people hundreds of thousands of times a year 2021-09-15T04:00:00Z He spent several minutes outlining the science behind the technology the company was developing, defining various types of tests — or assays — the company could perform. Elizabeth Holmes’s defense says mistakes, not malice, led to collapse of Theranos 2021-09-08T04:00:00Z It put him at the head of a trio that assayed the compositions of Steve Swallow, a bassist/composer and Scofield’s mentor. 6 performances to catch at the DC Jazz Festival, which returns to the Wharf 2021-08-27T04:00:00Z “It’s the timing and the antigen and the sensitivity of the assay — these are going to be very important,” Dr. Iwasaki said. Wondering if the Vaccine Worked? Get the Right Test, at the Right Time 2021-06-20T04:00:00Z We needed new assay chemistry that would still work with the device’s format but target virus RNA instead of wildlife sample DNA. Scientific collaboration emerges from pandemic crisis 2021-06-17T04:00:00Z Antibody responses to viruses are notoriously cross-reactive: the serological assays will react in the same way to related viruses, both known and as yet unrecognized. Finding Conclusive Animal Origins Of The Coronavirus Will Take Time 2021-06-09T04:00:00Z Hundreds of new assays were developed, he said. Elizabeth Holmes’s defense says mistakes, not malice, led to collapse of Theranos 2021-09-08T04:00:00Z The delay is due in part to a regulatory manufacturing issue related to an assay, the people briefed on the trial status told The Post. Maker of latest experimental vaccine not expected to seek authorization until June at the earliest 2021-05-10T04:00:00Z This test is a common method of determining whether mice and rats are experiencing pain, and she found that octopuses behave like their mammalian counterparts in the assay. Octopus ‘Teachers’ Demonstrate They Feel Emotional Pain 2021-04-23T04:00:00Z “There hasn’t been any evidence to show that a particular molecular assay or even an antigen test completely misses the boat in terms of detection,” said Neha Agarwal, the associate director of diagnostics at PATH. What the Coronavirus Variants Mean for Testing 2021-04-14T04:00:00Z These assays must be evaluated and validated in every species, and there is no gold standard test for a new virus in a new animal. Finding Conclusive Animal Origins Of The Coronavirus Will Take Time 2021-06-09T04:00:00Z The volunteers use commercial assays to look for virus-neutralizing antibodies and say they found none. Russia’s COVID-19 defense may depend on mystery vaccine from former bioweapons lab—but does it work? 2021-04-06T04:00:00Z “The filing timetable depends on completing the final phases of qualification and validation of the assays that are needed” to show regulators that the manufacturing process is consistent every time, Erck said. Maker of latest experimental vaccine not expected to seek authorization until June at the earliest 2021-05-10T04:00:00Z According to federal guidelines, the assay should not be used to identify potentially infected students. Why Virus Tests at One Elite School Ran Afoul of Regulators 2021-03-30T04:00:00Z That means carefully designed assays are needed to distinguish between different coronaviruses, for example. Scientists Are Trying to Spot New Viruses Before They Cause Pandemics 2021-02-15T05:00:00Z The tests, called neutralizing assays, will help determine the reliability of vaccines against the variant, he said. South Africa testing whether vaccines work against variant 2021-01-04T05:00:00Z “That will allow us to compare what we’re seeing in our assays,” says Cox. What we’ve learned about how our immune system fights COVID-19 2020-12-29T05:00:00Z “Thank you for your patience as CDC investigates reported sporadic aberrant reactivity in the N3 assay,” Villanueva wrote in an email. CDC squandered weeks pursuing complex test at pandemic’s start 2020-12-26T05:00:00Z The assays consisted of nine physical categories and six social ones, which were individually comprised of up to four different tasks repeated multiple times each. Young Ravens Rival Adult Chimps in a Big Test of General Intelligence 2020-12-10T05:00:00Z “The better the assay, the more complicated it is,” Dr. Crotty said. New Type of Test May Better Discern Immunity to the Coronavirus 2020-11-10T05:00:00Z The participants tested themselves at home for antibodies using finger-prick assays that deliver a yes-or-no result, much like a pregnancy test. Why You Shouldn’t Worry About Studies Showing Waning Coronavirus Antibodies 2020-10-27T04:00:00Z One of her bosses there, Herren Wu, now a senior vice president at AstraZeneca, remembers her skill with a difficult assay that bedeviled others. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z Nevada this month ordered nursing homes to stop using the point-of-care tests after they found more than 20 instances where positive findings were overturned by more precise assays. Rapid COVID test effort stumbles over risk of false positives 2020-10-10T04:00:00Z "I have not seen any independent evaluation of the Binax assay in the literature or in the blogs," Wells said. Inside the flawed White House testing scheme that failed to protect Trump 2020-10-06T04:00:00Z Now, he hopes his assay can help trace the path of the virus to humans and pinpoint when and where it first spilled over. This biologist helped trace SARS to bats. Now, he's working to uncover the origins of COVID-19 2020-09-30T04:00:00Z The findings were said to be confirmed through three live virus assays, and “robust neutralizing activity was observed in all participants 14 days after the second vaccination.” Moderna says coronavirus vaccine boosts immune system response in older adults 2020-09-30T04:00:00Z On September 28, several months after this story was originally published, the Trump administration announced a plan to distribute 150 million of these assays, developed by Abbott Laboratories. Millions of Rapid COVID-19 Antigen Tests May Help Fill the Testing Gap 2020-09-29T04:00:00Z If an antibody assay proved that you were immune to the coronavirus, there wouldn’t be any need to subject vaccine candidates to Phase III trials, which assess not just safety but also efficacy. I Got a Trial Covid-19 Vaccine. Do I Still Have to Wear a Mask? 2020-09-15T04:00:00Z Antigen assays are much faster and cheaper than the gold-standard polymerase chain reaction tests, which detect the virus’s RNA. Daily briefing: We still don’t fully understand fire 2020-09-16T04:00:00Z Wang’s assay works on a variety of species almost as well as the gold standard, says Peiris, who has been using it for several weeks in infected cats, dogs, and hamsters. This biologist helped trace SARS to bats. Now, he's working to uncover the origins of COVID-19 2020-09-30T04:00:00Z It reached that milestone after Indian authorities began using antigen assays to boost testing capacity. Fast coronavirus tests are coming — here’s what they can and can’t do 2020-09-15T04:00:00Z As of Sept. 10, the FDA contacted developers of 176 authorized assays for shipping information to send a standardized sample panel provided by the health agency. Nearly 60 coronavirus tests undergo performance checks by FDA 2020-09-16T04:00:00Z “When there was a huge backlog in national labs, that didn’t affect us like it did other states,” because New Mexico was not sending its assays elsewhere. How New Mexico Controlled the Spread of COVID-19 2020-09-15T04:00:00Z Lateral flow assays now being developed, which don’t require a machine but reagents and a drop of bodily fluid — blood, spit or nasal swab — are less accurate, often far less so. Boris Johnson’s ‘Operation Moonshot’ envisions weekly coronavirus tests for every person in Britain 2020-09-12T04:00:00Z They plan to use McPherson’s strategy to assess more antibodies against other targets, gauging performance across three common assays: immunoblot, immunoprecipitation and immunofluorescence. When antibodies mislead: the quest for validation 2020-09-06T04:00:00Z Abbott says the new assay will cost $5, and the company intends to produce tens of millions of the tests in September and 50 million in October. In ‘milestone,’ FDA OKs simple, accurate coronavirus test that could cost just $5 2020-08-27T04:00:00Z But the assay used in the paper, which targets the nucleoprotein of the virus, is particularly prone to false negative results, Slifka says. Some people can get the pandemic virus twice, a study suggests. That is no reason to panic 2020-08-24T04:00:00Z Nebraska was able to stretch its supplies by pooling, except among populations with high infection rates, which cause more groups to test positive and thus require more individual assays. What if We Worried Less About the Accuracy of Coronavirus Tests? 2020-08-20T04:00:00Z Indeed, in in vitro assays, Nottingham et al. report Q10 values of 2 or less for specific respiratory enzymes in soil samples from the studied plots. Carbon dioxide loss from tropical soils increases on warming 2020-08-11T04:00:00Z Those that worked best for each assay had not appeared in the literature at all1. When antibodies mislead: the quest for validation 2020-09-06T04:00:00Z Researchers noted further research is needed to improve the assay and validate the findings in unselected and diverse populations. New blood test detects Alzheimer's on par with expensive diagnostic tools, study finds 2020-07-29T04:00:00Z They then used these data to interpret the results of another assay that identifies the RNA sequences bound by RNA-binding proteins in vivo. Expanded ENCODE delivers invaluable genomic encyclopedia 2020-07-28T04:00:00Z “I personally find it very reassuring that these different groups are using different types of assays and getting the same result,” Dr. Schindler said. ‘Amazing, Isn’t It?’ Long Sought Blood Test for Alzheimer’s in Reach 2020-07-28T04:00:00Z In the United States, viral diagnostic assays account for the majority of tests conducted. The explosion of new coronavirus tests that could help to end the pandemic 2020-07-16T04:00:00Z The serum goes to the city’s public health lab, where the city uses one of two tests: either the DiaSorin Liaison assay, or the Abbot Alinity i serology test. D.C. has tested 13,706 blood samples. Only 809 carried coronavirus antibodies. 2020-07-15T04:00:00Z The new test, referred to by scientists as an “assay,” was called “Trioplex” and was intended to provide convenience for labs that wanted to look simultaneously for Zika and the other pathogens. Lessons unlearned: Four years before the CDC fumbled coronavirus testing, the agency made some of the same mistakes with Zika 2020-07-03T04:00:00Z The new test, referred to by scientists as an “assay,” was called “Trioplex,” and was intended to provide convenience for labs that wanted to look simultaneously for Zika and the other pathogens. Four years before the CDC fumbled coronavirus testing, the agency made some of the same mistakes with Zika 2020-07-04T04:00:00Z Most allegations suggest that images of molecular assays contain duplication or inappropriate altering. Former Harvard researcher who sexually harassed postdoc sparks turmoil at Italian institute 2020-07-01T04:00:00Z When tested multiple times on samples from 12 people infected with coronavirus, the assay detected the virus on nearly every occasion. The explosion of new coronavirus tests that could help to end the pandemic 2020-07-16T04:00:00Z The assay resembles the shape of proteins from the real coronavirus. D.C. has tested 13,706 blood samples. Only 809 carried coronavirus antibodies. 2020-07-15T04:00:00Z He tried to persuade officials at the Centers for Disease Control and Prevention to allow its assay to be used for pooled testing. Federal Officials Turn to a New Testing Strategy as Infections Surge 2020-07-01T04:00:00Z But the cell-separation steps involved meant that the assay was “too hard and laborious to be scaled”, he says. PredictImmune: a blood test to tailor treatment for bowel condition 2020-06-29T04:00:00Z For now, researchers and companies test them batch by batch, each using different assays depending on the drug they’re developing. How extracellular vesicles can enhance drug delivery 2020-06-16T04:00:00Z These assays, which are inexpensive to produce and simple to conduct, are already used to detect influenza infections. The explosion of new coronavirus tests that could help to end the pandemic 2020-07-16T04:00:00Z So it is unlikely these assays will be able to plug the testing shortage in the near future. African Countries Scramble to Ramp up Testing for COVID-19 2020-06-16T04:00:00Z Each positive antibody test is checked against the gold standard in the field: an assay to determine whether the antibodies are powerful enough to neutralize the virus, which is the hallmark of immunity. Large-scale survey of Seattle-area kids shows 1% had antibodies to the coronavirus 2020-05-30T04:00:00Z Next, the group analysed about 30 specimens with its own test alongside other assays in clinical labs, to vet its= accuracy. Scientists baffled by decision to stop a pioneering coronavirus testing project 2020-05-21T04:00:00Z Hertz’s approach does have potential to make assays more efficient, says Allen Bateman, assistant director of the Wisconsin State Laboratory of Health’s Communicable Disease Division, where he oversees COVID-19 testing. Coronavirus Test Shortages Trigger a New Strategy: Group Screening 2020-05-13T04:00:00Z Another hurdle is scaling up the assays for mass production. The explosion of new coronavirus tests that could help to end the pandemic 2020-07-16T04:00:00Z The technique often involves a technology—called a lateral flow assay—similar to that employed in home pregnancy tests. ‘Breakthrough’ COVID-19 Tests Are Currently Cheap, Fast—and Not Very Accurate 2020-05-07T04:00:00Z These methodological problems and perceived lack of transparency are exacerbated by the ubiquity of subpar assays. What COVID-19 Antibody Tests Can and Cannot Tell Us 2020-05-05T04:00:00Z And as COVID-19 was spreading around the world in February, the team retooled its assay to identify the new virus. Scientists baffled by decision to stop a pioneering coronavirus testing project 2020-05-21T04:00:00Z The U.S., for instance, does hundreds of thousands of tests a day, but that number is still far short of the millions of daily assays recommended for a safe return to normal. Coronavirus Test Shortages Trigger a New Strategy: Group Screening 2020-05-13T04:00:00Z The test uses different reagents than the PCR-based SARS-CoV-2 ones that are currently in use, offering a potential alternative where there are shortages of the chemicals needed to conduct the latter assays. CRISPR Gene Editing May Help Scale Up Coronavirus Testing 2020-04-23T04:00:00Z “You can’t be dependent on the throughput of laboratories and the availability of medical and laboratory professionals,” as PCR assays typically require, to conduct widespread testing, he says. ‘Breakthrough’ COVID-19 Tests Are Currently Cheap, Fast—and Not Very Accurate 2020-05-07T04:00:00Z They measure antibody levels with a more sophisticated assay called an ELISA. The researchers taking a gamble with antibody tests for coronavirus 2020-04-20T04:00:00Z Covid-19, because of its dissimilar genome, “is like the easiest target in the world. . . . It’s not a hard thing to develop an assay to.” Contamination at CDC lab delayed rollout of coronavirus tests 2020-04-18T04:00:00Z They oversaw our test, benchmarked it against their assay, and signed it off. These cancer scientists turned their lab into a coronavirus-testing facility 2020-04-15T04:00:00Z Last week researchers published a study in Nature Biotechnology describing a new assay for the novel coronavirus that causes COVID-19 that uses the technique to deliver results in about 40 minutes. CRISPR Gene Editing May Help Scale Up Coronavirus Testing 2020-04-23T04:00:00Z “The small amount of virus particles detected at 13 feet was not only the lowest of any sample the investigators assayed, but it was only weakly positive.” Latest coronavirus research challenges assumptions on spread, reinfection 2020-04-15T04:00:00Z We are also improving the tools and methods used to detect and diagnose infectious diseases—called biological assays. Disease Outbreaks Happen All the Time, But... 2020-04-11T04:00:00Z “So it’s really important from an epidemiological perspective to do these types of serology assays.” Will an Antibody Test Allow Us to Go Back to School or Work? 2020-04-10T04:00:00Z “I wouldn’t be surprised if you end up around 50%-60%. Even if they’re not that costly, why burn all those assays if that’s the information you get?” Coronavirus 'game changer' testing kits could be unreliable, UK scientists say 2020-04-05T04:00:00Z They're in their labs, nearly killing themselves to make assays, to do testing, to study this virus and come up with a solution. Jolted by Her Own Illness, Pandemics Scholar Gains Insight into Botched COVID-19 Response 2020-04-04T04:00:00Z His lab is currently running a serological assay to find potential plasma donors. Here’s How Coronavirus Tests Work—and Who Offers Them 2020-03-27T04:00:00Z Dr. Crystal Mackall, a Stanford physician who researches immunotherapies, called the rapid development of the antibody assay a “quite impressive” accomplishment. Wanted: A coronavirus test to identify people who were infected and then recovered 2020-03-25T04:00:00Z These consortia, which combine academic and industry expertise, offer hope for the development of robust and reproducible liquid-biopsy assays. The future of liquid biopsy 2020-03-24T04:00:00Z The company tested multiple assays that analyse circulating tumour DNA in blood samples from a cohort of 3,600 people with and without cancer6. Could liquid biopsies help deliver better treatment? 2020-03-24T04:00:00Z The initial failure of the CDC's test kits - the assays they had sent to labs across the nation - wasn't readily available knowledge at first. Jolted by Her Own Illness, Pandemics Scholar Gains Insight into Botched COVID-19 Response 2020-04-04T04:00:00Z “We don’t expect any hurdles to making these assays — just some tinkering to do,” says Garry. Coronavirus tests: researchers chase new diagnostics to fight the pandemic 2020-03-22T04:00:00Z Diagnostic assays that identify active infections in people are vitally important for public health efforts, not just for individuals’ health concerns. The standard coronavirus test, if available, works well—but can new diagnostics help in this pandemic? 2020-03-22T04:00:00Z One US pathologist told the BBC that hospital laboratories across the country were ready to develop test assays five weeks ago but were unable to move forward due to existing FDA regulations. Will US be ready in the weeks ahead? 2020-03-17T04:00:00Z This means that tests designed to catch epithelial cells are generally effective CTC assays. Could liquid biopsies help deliver better treatment? 2020-03-24T04:00:00Z And that’s why many in the industry are working to test potential therapies and vaccines: cell-based assays, viral screening and other tools. Coronavirus: A 5-point plan for pharmaceutical companies 2020-03-13T04:00:00Z In the meantime, Hodskinson and colleagues’ study underlines the need to develop better assays to study ICLs and other types of DNA damage in cells. A safe fix for alcohol-derived DNA damage 2020-03-03T05:00:00Z The assay should not react to this negative control, but the CDC reagents did at many, but not all, state labs. The United States badly bungled coronavirus testing—but things may soon improve 2020-02-28T05:00:00Z Even then, those labs were clamoring for the ability to test and questioning why it was taking so long to develop assays for the new coronavirus. Latest U.S. Coronavirus Case Suggests True Scope of Undetected Spread is Unknown 2020-02-27T05:00:00Z The assay uses beads coated with antibodies that bind to known epithelial cell proteins to capture CTCs. Could liquid biopsies help deliver better treatment? 2020-03-24T04:00:00Z Throat swabs and sputum samples were tested for a genetic match to the virus using an RT-PCR assay sanctioned by the World Health Organization. Medical report underscores the limits of screening travelers for coronavirus 2020-02-18T05:00:00Z It remains to be seen whether triiodothyronine was not observed in the current study because of the experimental conditions or because of the sensitivity of the assay used. Molecular architecture of the key precursor of thyroid hormones revealed 2020-02-04T05:00:00Z The revelation is different for each broadcaster, but whatever it is, it must be real — and the assay of authenticity is his willingness to go too far. Opinion | Don Imus, the man who was always willing to go too far 2019-12-31T05:00:00Z Direct chimaera–BamA binding was confirmed with in vitro assays in which the authors fluorescently labelled the chimaeras and monitored changes in fluorescence that indicate binding to a large protein such as BamA. New antibiotics target the outer membrane of bacteria 2019-12-08T05:00:00Z They frequently and successfully employ their mass spectrometers as tools for inspecting mAbs prior to assay development. How Mass Spectrometry Can Help Limit Reproducibility Problems 2019-11-08T05:00:00Z Biswas, who developed the assay and created the center's phage bank, says the assay allows new viruses to be easily swapped in to counter the onset of resistance. Phage Therapy Could Beat Drug-Resistant Illnesses 2019-11-05T05:00:00Z For example, the League of Nations Health Organization created the Permanent Commission on Biological Standardisation to monitor drug tests and biological assays from 1924. Data — from objects to assets 2019-10-14T04:00:00Z In most applications, the microfluidic assay must run multiple analytical reactions on the same liquid sample. Micro-engineered liquid flow dissolves solids without dispersing them 2019-10-08T04:00:00Z “The gold is genuine, but it’s not ethically sourced ... They look completely genuine, they assay correctly, and they weigh correctly as well.” Exclusive: Fake-branded bars slip dirty gold into world markets 2019-08-28T04:00:00Z This would be a powerful assay for detecting whether protein–protein interactions affect Piezo transduction, and for investigating how channel flattening might link to gates in the pore. A mechanism for touch 2019-08-20T04:00:00Z The navy assay checks only for bacterial cell death; it does not reveal which receptors are targeted. Phage Therapy Could Beat Drug-Resistant Illnesses 2019-11-05T05:00:00Z What the blood assays for the tau protein, the main component of tangles in the brain, tell us is little less certain. Two experts on why new Alzheimer's studies are encouraging 2019-08-10T04:00:00Z Still, sensors need to be able to collect and analyse sweat without it becoming contaminated or degrading, and they will also require new chemical tests and types of assay. Skin sensors are the future of health care 2019-07-16T04:00:00Z Only three labs nationwide use modern assays to screen for HIV. Exclusive: North Korea claimed to be free of HIV. But infections appear to be surging 2019-06-24T04:00:00Z And methods to assay the DNA sequence in an embryo rely on removing a small number of cells for testing, and then destroying them. CRISPR babies: when will the world be ready? 2019-06-18T04:00:00Z The first insights were obtained from assays that used poorly characterized enzyme preparations isolated from dinoflagellates7,8. Enzymes that detoxify marine toxins 2019-06-09T04:00:00Z Testing the function Various assays are used to test how well a prospective biosimilar binds to its biological target, and to confirm that the drug replicates the effect and specificity of the original biologic. Bring on the biosimilars 2019-05-07T04:00:00Z Laboratorians across the U.S. are enthusiastic about implementing state-of-the-art technology and assays. A Shortage of Skilled Medical Lab Workers Is Looming 2019-05-03T04:00:00Z By testing for as many as 80 different blood analytes, Arivale’s assays revealed “the intersection of your genetic predisposition and your life choices” said CEO Lewis. Closure of high-tech medical firm Arivale stuns patients: “I feel as if one of my arms was cut off” 2019-04-26T04:00:00Z Because molecular assays provide a limited window in which to diagnose infection, the authors opted to use serological assays to measure antibody levels at different time points. Effects of dengue immunity on Zika virus infection 2019-03-24T04:00:00Z Writing in Nature, Baek et al.2 provide an example of the power of such strategies, using a combination of state-of-the-art neuroscience techniques and a creative behavioural assay in mice. Biological clues to an enigmatic treatment for traumatic stress 2019-02-12T05:00:00Z Many of these were found to be pharmacologically active in assays. Bigger is better in virtual drug screens 2019-02-05T05:00:00Z Maybe you fire one plasma lance too many to assay yet another worthless nickel–iron lode. Cold memories 2019-01-01T05:00:00Z The challenge remains to turn these basic biological insights into predictive assays that can identify the patients most suitable for BTK-blocking therapy. Precision therapies take aim at non-Hodgkin’s lymphoma 2018-11-13T05:00:00Z The assay uses a technique called Förster resonance energy transfer, or FRET, to detect physical contacts between astrocytes and neurons that express fluorescent proteins on their surface. Tapping into the brain’s star power 2018-10-30T04:00:00Z After all the grinding and leaching, the gold wends its way to the fire assay lab. Mining company pays millions for gold dug from mine dumps 2018-10-27T04:00:00Z It’s a quick way to assay the campaign landscape, and if those ads feature some wicked representation of herself, she’s not at all bothered. They say terrible things about Nancy Pelosi. Her response: Just win, Democrats - Los Angeles Times 2018-10-26T04:00:00Z They don’t have the resolution to determine ancestry and relatedness in the same way that SNP assays based on 1 million variants do, and false positives are common in familial searches. Supercharged crime-scene DNA analysis sparks privacy concerns 2018-10-10T04:00:00Z These mice were indistinguishable from controls in a set of behavioural assays. Absent forebrain replaced by embryonic stem cells 2018-10-09T04:00:00Z Helen Hunt make much ado about “Much Ado About Nothing,” then F. Murray Abraham assays the quality of “The Merchant of Venice” when “Shakespeare Uncovered” returns with back-to-back new episodes. TV This Week, Oct. 7-13: 'Crazy Ex-Girlfriend,' 'Doctor Who' and more - Los Angeles Times 2018-10-05T04:00:00Z The other 5 monkeys in this group remained completely clear of any detectable virus, even using sensitive assays. Combination treatment prevents HIV re-emergence in monkeys 2018-10-02T04:00:00Z It shares a Latin root with the English word assay. The pleasures of ambiguity: David L. Ulin on 'Essayism' by Brian Dillon - Los Angeles Times 2018-10-03T04:00:00Z We must develop standardized analyses of gene expression, including on a cell-by-cell basis, and rigorous assays to establish the precise products of cell differentiation in various tissues. Clear up this stem-cell mess 2018-09-25T04:00:00Z A: Genes that express more protein get more attention because they’re easier to study—there is more material to put through an assay. There are about 20,000 human genes. So why do scientists only study a small fraction of them? 2018-09-18T04:00:00Z By using both inhibitory and excitatory manipulations, and combining these with the latest in genetic tools, imaging technology, behavioural assays and computational modelling, our understanding of how our powerful brains function will deepen considerably. Protein structures guide the design of a much-needed tool for neuroscience 2018-09-16T04:00:00Z Such efforts typically combined computational models with in vitro assays of, for example, protein–protein interactions or drug sensitivity. Gene editing reveals the effect of thousands of variants in a key cancer gene 2018-09-11T04:00:00Z Such assays must be subjected to extensive, rigorous testing across different populations, and their limitations must be made clear. Molecular test of age highlights difficult questions 2018-09-03T04:00:00Z In 2000, she landed a technician job at an HIV lab at the University of Nairobi, where she performed immunology assays, made buffers and did other tasks. How working as a research technician can bolster your scientific career 2018-08-20T04:00:00Z Another problem, Iorns adds, is that academic labs rarely validate their assays, making it difficult to know whether a positive result is real or “just noise.” Plan to replicate 50 high-impact cancer papers shrinks to just 18 2018-07-31T04:00:00Z Schroth says that between the reagents, the hardware and the analysis tools, these assays are so customized that they could prove difficult to reproduce in other labs, at least without a knowledgeable insider to help. The hackers teaching old DNA sequencers new tricks 2018-07-23T04:00:00Z But further thought is required to determine the best way to incorporate Findlay and colleagues’ assay into variant classification. Gene editing reveals the effect of thousands of variants in a key cancer gene 2018-09-11T04:00:00Z The company is launching products and services that seamlessly integrate into existing workflows for biomarker discovery, assay validation, and companion diagnostic applications. Ultivue Launches UltiMapper™ Portfolio of Reagents for Tissue Marker Detection and Analysis at High 2018-07-10T04:00:00Z And we started to develop our own simple assays … to estimate age for forensic purposes. Crime scene DNA could be used to reveal a suspect’s age—and whether they have cancer 2018-07-03T04:00:00Z I will assay a translation into standard English: White began her exploration with no thought to pinning down the truth of truly egregious charges against Richardson. A Toothless Investigation Slaps Jerry Richardson on the Wrist 2018-06-29T04:00:00Z In another assay, the researchers presented mice with a dark circle that loomed overhead, simulating an approaching predator. A molecular signature for social isolation identified in the brain 2018-06-17T04:00:00Z For these genes, non-functional variants would be expected to alter cell growth in culture, enabling a modification of Findlay and colleagues’ frequency assay to be used. Gene editing reveals the effect of thousands of variants in a key cancer gene 2018-09-11T04:00:00Z He trained as a conservator of paintings, but now he assays them: picks out their chemical constituents, inspects pigments and binders, peers under their washes of colour. How to spot a perfect fake: the world’s top art forgery detective 2018-06-15T04:00:00Z The rationale is that if the drug causes the person’s organoids to swell under assay conditions, then the patient is likely to respond, too. Stem-cell culture moves to the third dimension 2018-06-10T04:00:00Z Other gene assays exist, but this one is the most widely used in the United States. Good News for Women With Breast Cancer: Many Don’t Need Chemo 2018-06-03T04:00:00Z At the Pantages, the role is assayed by Adrianna Hicks, an ensemble player in the Broadway revival who hasn’t quite made the leap to headliner. 'The Color Purple' national tour turns down the wattage — and burns a little less brightly 2018-05-30T04:00:00Z The effort involved in developing such an assay for each gene is substantial, and will probably slow the immediate application of SGE for assessing VUS. Gene editing reveals the effect of thousands of variants in a key cancer gene 2018-09-11T04:00:00Z The company is scheduled to expand the Rhapsody platform to include protein detection with its own AbSeq assays — developed independently of Abate — later this year. Single-cell approaches to immune profiling 2018-05-21T04:00:00Z The rest of the hundreds of routine assays the lab was supposed to deliver would require cytometry, general chemistry and DNA amplification. Blood, sweat and tears in biotech — the Theranos story 2018-05-13T04:00:00Z Protein concentrations were determined using the Bradford assay. d, Confocal microscopy images of highly expanded crystal–hydrogel hybrids, showing the structural deterioration of the facets and the edges. Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks 2018-05-01T04:00:00Z Scale bar, 100 µm. b, Calibration of the assay and primary screen. Blastocyst-like structures generated solely from stem cells 2018-05-01T04:00:00Z The merger of a method for high-throughput chemical synthesis with a biochemical assay would facilitate the exploration of this enormous search space and streamline the hunt for new drugs and chemical probes. Nanoscale synthesis and affinity ranking 2018-04-22T04:00:00Z This might include helping a client to synthesize compounds, run biochemical assays or conduct animal studies. Outsourcing is in 2018-04-10T04:00:00Z The company’s alluring goal, which changed as it evolved, was to quickly analyse a drop of blood for hundreds of different assays, at a fraction of prevailing costs. Blood, sweat and tears in biotech — the Theranos story 2018-05-13T04:00:00Z The assays were applied to proteins to be secreted and those that would end up spanning membranes. Günter Blobel (1936–2018) 2018-03-22T04:00:00Z J.K. completed the blastocyst complementation assays and the in uteri transfers. Blastocyst-like structures generated solely from stem cells 2018-05-01T04:00:00Z By using the best of four reaction conditions, 187 additional products were produced and assayed that bound to CHK1; the colour of the dots reflects the affinity ranking of the compounds. Nanoscale synthesis and affinity ranking 2018-04-22T04:00:00Z “Did you initiate a project, implement a new technique, or optimize an assay? What was innovative about your research? What did you shed light on to change scientific understanding?” How to sail smoothly from academia to industry 2018-03-20T04:00:00Z In the case of 23andMe’s cancer assay, the three mutations measured are most common in people of Ashkenazi, or Eastern European Jewish descent. FDA Approval of 23andMe Kit Is Latest Example of Agency’s Course Reversal 2018-03-09T05:00:00Z One early assay came in the 1950s, at the dawn of ready-to-wear fashion. Avedon's Animal Side 2018-02-08T05:00:00Z Finally, Piezo is required for both mechanical activation of stem cells in a gut expansion assay and the increase of cytosolic Ca2+ in response to direct mechanical stimulus in a gut compression assay. Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel 2018-02-06T05:00:00Z Consider a commonly used assay in which the production of a fluorescent protein is used to monitor cell activity. Robust research needs many lines of evidence 2018-01-22T05:00:00Z “We are creating devices that collect information, new molecular assays — and all of that is just to try to understand health at a deeper level,” said Dr. Jessica L. Mega, Verily’s chief medical officer. How Big Tech Is Going After Your Health Care 2017-12-26T05:00:00Z OASIS: online application for the survival analysis of lifespan assays performed in aging research. A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage 2017-11-21T05:00:00Z This file contains a comprehensive list of all human infectious derived, class-I restricted peptide sequences with positive immune assays derived from the Immune Epitope Database used in this study. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer 2017-11-07T05:00:00Z Like teenagers entering a new school, regions and countries – from Lipetsk to the US – feel compelled to assay their identity, change it up, build it out. How to sell a country: the booming business of nation branding 2017-11-07T05:00:00Z All assays were run in triplicates and normalized to Gapdh control. Dynamic landscape and regulation of RNA editing in mammals : Nature : Nature Research 2017-10-10T04:00:00Z Screening assays have since made the transmission of viruses through donated blood rare. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z One challenge was to precisely assay the uranium isotopes, which could shed light on the material's source; on at least one measurement, COE scientists came out tops. U.S.-China mission rushes bomb-grade nuclear fuel out of Africa 2017-08-31T04:00:00Z Other discrepancies are probably based on small methodological differences in survival assays. A long journey to reproducible results 2017-08-21T04:00:00Z Dr Sukumar and his team claim that their study is the "first to examine the relationship between body condition, seasonality and stress in wild Asian elephants using large-scale faecal sample collection for assaying glucocorticoid metabolites". Freeze-dried dung gives clue to Asian elephant stress - BBC News 2017-08-16T04:00:00Z The existence of the Ebola assay is a sign that the world’s ability to respond to outbreaks of the virus has improved. Ebola outbreak in Africa ends — but gaps in public health leave region vulnerable 2017-07-01T04:00:00Z Screening blood donations for pathogens using a battery of separate assays takes a considerable amount of effort and money. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z Microarrays for running assays on large numbers of genes at once were brand-new. Wanted: More Data, the Dirtier the Better 2017-06-12T04:00:00Z Not one to surrender easily, McHugh decided on his own motivational tactic: He flew to Delaware, walked into a U.S. government assay office, and asked for $25,000 worth of gold. Landmark F.X. McRory’s closing but owner Mick McHugh hopes to relocate 2017-06-10T04:00:00Z It seems all but a right of passage for British actors to portray Winston Churchill, with Richard Burton, Albert Finney and Timothy Spall among the many thespians who have assayed the legendary prime minister. ‘Churchill’ star Brian Cox on inhabiting the prime minister on eve of D-Day 2017-05-29T04:00:00Z The detection limit in the plaque assay is 10 p.f.u. ml−1 in cell supernatant, and 100 p.f.u. ml−1 in serum. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes : Nature : Nature Research 2017-05-16T04:00:00Z “Those assays look very promising,” says Patricia Hewitt, a transfusion medicine specialist with the UK National Health Service Blood and Transplant authority. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z The assay works by color: Insulin turns a sample very slightly yellow, a change researchers detect using a specialized instrument. When the Lab Rat Is a Snake 2017-05-17T04:00:00Z Investigators must track the genetic shifts in cancer cells in real time by setting up prospective assays that sample and analyse tumours during therapy. Liquid-biopsies success highlights power of combining basic and clinical research 2017-04-25T04:00:00Z Which then gives rise to friendship’s least appealing aspect – its reliance on death as the ultimate assay. Richard Ford: ‘Who needs friends?’ 2017-04-22T04:00:00Z On that radio show, Tagliabue assayed a defense of his legacy on concussions. Paul Tagliabue Yearns for Hall of Fame, but Concussions Tarnish Legacy 2017-02-03T05:00:00Z And validating the assays could be difficult because there are precious few samples of blood from infected individuals — fewer than 250 people have developed vCJD worldwide. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z Writer Mike White seems to have made a career of it, assaying oddballs and misfits and the indignation, righteous and otherwise, that can follow with them. Mike White and Miguel Arteta serve up Trump-era allegory in 'Beatriz at Dinner' 2017-01-26T05:00:00Z Ruoslahti points out that the contract lab apparently did not do any assays to verify that the peptide had activity before testing its effect on tumors. Rigorous replication effort succeeds for just two of five cancer papers 2017-01-18T05:00:00Z Yet no one assays this territory quite like Alex Ross Perry. First look at 'Golden Exits' with Jason Schwartzman, Chloë Sevingy and Beastie Boys' Adam Horovitz 2017-01-18T05:00:00Z The consortium decided to vet both antibody samples and antibody assays and included as many samples and scientists as possible. How to turn competitors into collaborators 2017-01-16T05:00:00Z However, Soto thinks that at least some countries will still want the assay. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z Four markers were selected for predictive marker assays on the basis of this analysis and previous work on the Danish Test Panel of 58 trees3. Genome sequence and genetic diversity of European ash trees : Nature : Nature Research 2016-12-25T05:00:00Z They may disrupt cell membranes, duping assays that try to spot drugs targeting specific cell-membrane proteins. Deceptive curcumin offers cautionary tale for chemists 2017-01-10T05:00:00Z And yes, as a 21st-century U.S. male, I am well aware of the minefield a guy enters when he assays public discussion of a woman’s looks. Thanks for being you, Michelle 2017-01-08T05:00:00Z Third, researchers perform their assays so differently that comparison across groups is difficult, if not impossible. How to turn competitors into collaborators 2017-01-16T05:00:00Z In August 2017, the American Red Cross began using another assay, developed by Spanish pharmaceutical company Grifols, to screen for B. microti, as part of a clinical trial to test the assay's performance. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z In previous centuries, physicians made this last diagnosis by tasting urine for sweetness, a time when taste buds were the only assay. Learning to love the secret language of urine 2016-11-22T05:00:00Z Reed served as auditor of the first First National Bank of Omaha, president of the local assay commission, Omaha city clerk, 1860-67; deputy Douglas County clerk, 1861-63; and county clerk, 1863-65. Museum’s Byron Reed collection honors city’s founder 2016-11-12T05:00:00Z “We could design assays based on things we've had for years in the prion field, based on amplification of misfolded proteins,” says Watts. Pathology: The prion principle : Nature : Nature Research 2016-10-25T04:00:00Z Laboratories use different assays, cell types, virus isolates, dosing schedules and antibody concentrations. How to turn competitors into collaborators 2017-01-16T05:00:00Z In 2016, two research groups published reports of even more sensitive assays. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z But by the end of last year, the worsening Zika outbreak “increased the urgency to quickly develop an assay,” CDC investigators found. CDC whistleblower claims agency has been using wrong Zika test 2016-09-27T04:00:00Z The last chapter assays some brave, liberal cheer, calling for an upsurge in human empathy. Blessed are the cheesemakers 2016-09-20T04:00:00Z But she will intrepidly attack any aria, scale its altitudes in great swoops and hoots, assay its descending trills with the vigor of a maudlin cuckoo.” What It Was Like to Hear the Real Florence Foster Jenkins Sing, as Told in 1934 2016-08-11T04:00:00Z Unbound antibodies were washed away for 1 min in assay buffer. Structural basis of potent Zika–dengue virus antibody cross-neutralization : Nature : Nature Research 2016-06-22T04:00:00Z “All screening assays will have a number of false positives,” she says. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z The researchers will then run assays on the liquid, which Kozlowski calls the “extract,” to test hormone levels. Zoo Poo and Glitter Reveal Animal Health Secrets Whether or not an antibody works depends on the particular assay. Biomedical researchers lax about validating antibodies for experiments 2016-06-29T04:00:00Z Using a procedure called a biocatalytic assay, the researchers looked for specific chemicals created by the enzyme’s activity. We Can Now Tell a Person’s Age Range From Crime Scene Blood 2016-06-29T04:00:00Z Dissociation of the complexes formed was then monitored for 10 min by dipping sensors in assay buffer alone. Structural basis of potent Zika–dengue virus antibody cross-neutralization : Nature : Nature Research 2016-06-22T04:00:00Z Confirmation is especially important when the assay is meant to detect a disease such as vCJD. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z It is arguable what this 'surrogate' assay actually measures. Cancer therapy: Defining stemness : Nature : Nature Publishing Group 2016-06-07T04:00:00Z Conservation organizations are training “river monitors” who travel on foot or by kayak to assay populations of fish and invertebrates and measure turbidity and dissolved oxygen as indicators of stream health. How Technology Affects Our Relationship With Nature 2016-06-07T04:00:00Z The GI Bill then paid for his education, and before long he was assaying a shiny law career. Louisville, Kentucky, offers tourism, bourbon at Bulleit, Derby Museum, Slugger factory 2016-06-05T04:00:00Z Prior to the assay, all species were subjected to ethanol shock and were cultured anaerobically to determine their ability to sporulate. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation : Nature : Nature Publishing Group 2016-05-03T04:00:00Z For plaque assays, the cells were not specially authenticated, and not tested specifically for mycoplasma contamination. Structure of the thermally stable Zika virus : Nature : Nature Publishing Group 2016-04-18T04:00:00Z These assays analyze a sample of cerebrospinal fluid, gathered by a painful lumbar puncture, to identify the presence of RNA from the three different viruses. Why Colombia could be the key to understanding Zika 2016-04-29T04:00:00Z Mr. Reiser studied music in college but then assayed right into stand-up as a young man. Paul Reiser, ‘Mad About You’ actor, returns to stand-up comedy 2016-02-19T05:00:00Z He had adequately assayed the chick and even imagined her lying on her mean little bed, despite the half-light. Tram 83, the Congolese novel that's wowing the literary world - extract 2016-01-07T05:00:00Z "If there was an inspection of a lab that's focused on novel technology and it didn’t explicitly examine the validation data for those assays, it would raise some significant concerns." Theranos’ proprietary tech wasn’t vetted by federal inspectors for two years 2015-12-30T05:00:00Z Next, they plan to test whether adding an assay for another molecule associated with aggressive cancer, SchLAP1, will further improve the test. Prognosis: Proportionate response : Nature : Nature Publishing Group 2015-12-14T05:00:00Z “It was kind of my dream job because it was two passions, acting and history, rolled into one,” she said of the role she assayed for two seasons. Natalie Dormer on Cressida’s final adventure in ‘The Hunger Games: Mockingjay — Part 2’ 2015-11-19T05:00:00Z She says that the assay can pick out some women who are at a high risk of recurrence, but whom doctors might have considered to be low risk based on patient history and tumour characteristics. Molecular biology: Marked progress : Nature : Nature Publishing Group 2015-11-17T05:00:00Z Such assays are less reliable when only one or a few cells are available, as with cells biopsied from early embryos. CRISPR: A path through the thicket 2015-11-09T05:00:00Z “The two cell types appear functionally indistinguishable based on the assays we used,” Hochedlinger says. Reprogrammed stem cells work as well as those from embryos 2015-10-26T04:00:00Z Theranos received approval from the FDA in July for the test, its only assay that has the agency’s approval. Theranos doesn’t want its tech compared to other machines — except when it’s convenient 2015-10-23T04:00:00Z Mice lacking the gene for immunoglobulin tested negative for GDF11/8 using the Novartis assay, they report today online in Circulation Research. Antiaging protein is the real deal, Harvard team claims 2015-10-21T04:00:00Z The differences may show up, for example, in more complicated behavioral assays and drug tests, which Silverman and Yang are exploring. Can Female Mice Improve Autism Research? 2015-10-20T04:00:00Z Genetic variants that influence the clinical effects of some medications can now be reliably assayed in the clinical setting. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z These approaches include clinical trials and other therapeutic options as part of a molecular assay report, such as FoundationOne from Foundation Medicine, and connections to further information, consumer-focused advice, communities and patient-led consortia. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z Evidently this method of testing worked to the FDA’s satisfaction, and Theranos clearly consented to this when it started submitting its assays to the FDA. Theranos doesn’t want its tech compared to other machines — except when it’s convenient 2015-10-23T04:00:00Z The Novartis group concluded from a different assay that GDF11 levels in blood actually rise with age in rats and people. Antiaging protein is the real deal, Harvard team claims 2015-10-21T04:00:00Z Differences in gene expression and other markers are just a start; they must be followed up with studies that explore the underlying biology of the skin, assays of active ingredients and numerous other steps. Cosmetics: Molecular beauty : Nature : Nature Publishing Group 2015-10-06T04:00:00Z There is increasing evidence to show that genotyping multiple genes in a single assay is more cost-effective, uses the DNA in the sample more efficiently, and facilitates the pre-emptive availability of genetic-test information. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z The challenges of delivering molecular assays using advanced technologies are discussed elsewhere56, however, current tests exploit the relatively direct relationships that exist between a specific mutation and the efficacy of a drug. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z This is the case for a category of assays called "laboratory-developed tests." Theranos doesn’t want its tech compared to other machines — except when it’s convenient 2015-10-23T04:00:00Z Doctors tend to rely on the assay when they want more information before deciding whether to recommend chemotherapy to their patients. Early Stage Breast Cancer May Not Require Chemo 2015-09-28T04:00:00Z One way to assay the strength of the anti-monarchy movement might be by sizing up the military government’s efforts to counter it. With King in Declining Health, Future of Monarchy in Thailand Is Uncertain 2015-09-20T04:00:00Z However, improvements in technology mean that it is now possible to interrogate multiple genes in a single assay at lower cost than for multiple single-gene tests. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z The team stitched the gene for MDHAR6 into the bacterium E. coli, enabling the enzyme to be synthesised in large quantities for purification and subsequent assay against TNT. Mutant Plants Mop Up Explosives 2015-09-10T04:00:00Z Theranos was able to get to market very quickly by exploiting this system — because it manufactures and conducts its tests in a single lab, Theranos’ assays also fall under "laboratory-developed tests." Theranos doesn’t want its tech compared to other machines — except when it’s convenient 2015-10-23T04:00:00Z Younger age and a higher risk disease were more likely to predict chemotherapy use than the assay. Genetic Test Impact Chemo Choices In Surprising Ways 2015-08-27T04:00:00Z Kamat agrees that the most demanding part of the work was to develop suitable assays to do this. Origin of Life: First Cells May Have Been Glued Together 2015-08-13T04:00:00Z Some of her recent research refutes claims that glyphosate, an herbicide often used on GM crops, accumulates in breast milk; it relies on an assay developed with assistance from Monsanto. GM-crop opponents expand probe into ties between scientists and industry 2015-08-05T04:00:00Z Each sample was run three times on three separate assays. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic : Nature : Nature Publishing Group 2015-06-23T04:00:00Z “To roll out an assay with so many false positives is unthinkable,” Perkins says. Researchers frustrated by failure to roll out 'game-changing' Ebola test 2015-06-25T04:00:00Z Her doctor assays the dose - the technetium is continually decaying, so it is important to check that it is still sufficiently radioactive to produce an image, but not enough to be harmful. The element that can make bones glow - BBC News 2015-05-29T04:00:00Z Other research groups are gathering evidence for amyloid-β strains using nuclear magnetic resonance techniques, or applying prion assays to probe whether different strains of tau exist. Alzheimer’s research takes a leaf from the prion notebook 2015-05-28T04:00:00Z Some scientists buy half a dozen antibodies from different vendors, and then run a few assays to see which performs best. Reproducibility crisis: Blame it on the antibodies 2015-05-18T04:00:00Z First, there is a growing interest in 'omics' assays that expose people's unique characteristics at the molecular level. Personalized medicine: Time for one-person trials 2015-04-28T04:00:00Z Some are pricier and more complicated, like mammograms or assays for various molecules in the blood that correlate with various diseases. Quantifying Tests, Instead of Good Care 2015-04-13T04:00:00Z Among study participants with cancer, a polyp or another pre-cancerous condition in the lining of the colon or rectum, DNA testing predicted a higher proportion of abnormalities than did the blood assay alone. For Colon Cancer Screening, Cologuard Test Offers A Solid New Option 2015-03-06T05:00:00Z Alignment parameters for each assay type and experiment are specified in the associated publicly accessible Release 9 metadata archived at GEO. Integrative analysis of 111 reference human epigenomes : Nature : Nature Publishing Group 2015-02-17T05:00:00Z “If someone says, 'Here is an assay you can use,' you are so eager to test it you can forget that what has been promised is not the case.” Reproducibility crisis: Blame it on the antibodies 2015-05-18T04:00:00Z Specimen handling and transport is minimized, suggesting that this assay will be preferable, if results are confirmed in larger trials. A Dongle For Detecting HIV And Syphilis 2015-02-04T05:00:00Z He considers the new findings a key step toward his eventual goal of capturing that cross talk with a benchmark assay that measures the health of a person’s immune defenses at the systems level. Your Immune System Is Made, Not Born 2015-01-29T05:00:00Z The Englishman assays a convincing Scottish accent, issuing epithets against the capitalist class — whom he consistently refers to as “they” — while captaining a bilingual submarine toward the final subsurface destination of Stalin’s shipment of bullion. MOVIE REVIEW: ‘Black Sea’ 2015-01-29T05:00:00Z Complete metadata associated with each data set in this collection is archived at GEO and describes samples, assays, data processing details and quality metrics collected for each profiling experiment. Integrative analysis of 111 reference human epigenomes : Nature : Nature Publishing Group 2015-02-17T05:00:00Z The cheerful Mr. Goldman is set to assay not one but two shows on the network this spring, “Duff Till Dawn” and “Kids Baking Championship.” Duff Goldman of ‘Ace of Cakes’ bakes up 2 fresh Food Network shows, 1 with Valerie Bertinelli 2015-01-11T05:00:00Z It will be important to repeat those assays in dozens, if not hundreds, of strains more recently isolated from patients, he says. Promising antibiotic discovered in microbial ‘dark matter’ 2015-01-06T05:00:00Z That calls for sophisticated IT, a big database, new biosensors, and new cell assays to measure activity. New Allen Cell Observatory, With $100 Million, Promises Animated View Of Cell Behavior 2014-12-08T05:00:00Z With 60 patients, this added up to hundreds of assays every weekend. That Medical Test Costs $50, or Is It $500? 2014-11-20T05:00:00Z This observation was further validated by in vivo enhancer assays in transgenic mice. Principles of regulatory information conservation between mouse and human : Nature : Nature Publishing Group 2014-11-18T05:00:00Z “The potential for the assay is really there,” she says. Personalized cocktails vanquish resistant cancers 2014-11-12T05:00:00Z Unsurprisingly, these assays selected new compounds that act similarly to the drugs on which they were based2. Mental health: Depression needs large human-genetics studies 2014-11-11T05:00:00Z Lobel says that these data must be taken with a pinch of salt, and that the assays could actually be detecting immune responses to viruses similar to ebolaviruses. The Ebola questions 2014-10-28T04:00:00Z Currently, lab technicians use a gene-based assay to pick up genetic fingerprints of the Ebola virus. Two New Ebola Tests Fast Tracked by FDA 2014-10-28T04:00:00Z The in vivo enhancer activity assays were conducted at the E.O. Principles of regulatory information conservation between mouse and human : Nature : Nature Publishing Group 2014-11-18T05:00:00Z A typical assay screens many thousands of chemicals. Chemistry: Chemical con artists foil drug discovery 2014-09-23T04:00:00Z For those readers with medicinal chemistry interests, the supplementary material for the Nature paper contains the synthetic procedure and a more detailed description of the assays. BioCryst to Launch NHP Ebola Drug Safety Studies 'Within Weeks' 2014-08-29T04:00:00Z Specifically, for each species comparison, we calculated the significance of the overlap in GO term enrichments for all ChIP-seq experiments involving orthologous factors assayed in the two species. Comparative analysis of regulatory information and circuits across distant species : Nature : Nature Publishing Group 2014-08-26T04:00:00Z Generally, transcription factors assayed in multiple stages retain their upstream and downstream binding preferences. Regulatory analysis of the C. elegans genome with spatiotemporal resolution : Nature : Nature Publishing Group 2014-08-26T04:00:00Z “In general, for most of these tests, nobody is doing hand assays or looking into a microscope,” Hsia said. A blood test can cost from $10 to $10,000 in Calif. hospitals, according to a study For example, under certain assay conditions, some molecules — redox cyclers — produce hydrogen peroxide5, an antiseptic that is also produced by certain immune cells. Chemistry: Chemical con artists foil drug discovery 2014-09-23T04:00:00Z That’s how much one California hospital charges for a routine cholesterol test, while others charged as little as $10 for the exact same assay. Morning Must Reads: August 15 2014-08-15T04:00:00Z Chuck Myers, who used to be a curator here, developed a rather effective assay in the 1970s, which was to touch his tongue to the back of a frog. A Toxic Menagerie 2014-07-31T04:00:00Z True biological duplicates—in which binding was assayed for the same developmental stage and factor, as driven by the same promoter, and assayed with the same ChIP protocol—share 77–92% of the binding sites. Regulatory analysis of the C. elegans genome with spatiotemporal resolution : Nature : Nature Publishing Group 2014-08-26T04:00:00Z “But in end of day we needed commercial expertise to look at the assay and discuss with customers about whether there was any commercial value in the product.” UK Start-up Creating Animal-free Drug Testing 2014-07-31T04:00:00Z Assess assays.For each hit, conduct at least one assay that detects activity with a different readout. Chemistry: Chemical con artists foil drug discovery 2014-09-23T04:00:00Z This proof-of-principle work hints at the possibility of doing away with computers to read diagnostic assays in the future, says Milan Stojanovic of Columbia University. Molecular Computer Detects Ebola and Marburg Viruses 2014-07-21T04:00:00Z For biochemical markers, the best evidence is with spinal fluid assays for tau protein or amyloid. Why Alzheimer's Drugs Keep Failing 2014-07-14T04:00:00Z We examined this relationship among 13 ‘focus’ factors, for which both embryonic binding and cellular expression were assayed. Regulatory analysis of the C. elegans genome with spatiotemporal resolution : Nature : Nature Publishing Group 2014-08-26T04:00:00Z Maryman underwent test after test: MRI scans, increasingly sophisticated blood assays to rule out malaria and exotic parasites, and a bone marrow biopsy to check for cancers both common and rare. A fever gripped a woman every afternoon, only to slide back to normal while she slept Be wary of compounds that do not show activity in both assays. Chemistry: Chemical con artists foil drug discovery 2014-09-23T04:00:00Z While assays exist for the currently illicit substance, the same test may not be able to identify a related designer drug. Molecular Detector Could Find Meth And Other Illegal Drugs 2014-06-19T04:00:00Z The rapid discovery of new species involves new techniques, like molecular assaying. An Amphibian’s Best Friend 2014-05-26T04:00:00Z The attorney general and the governor assayed an awkward, quick bro hug. Nod, Smile and Wave While You Can (Wink!) 2014-05-22T04:00:00Z For decades, the same molecules have shown up in screening assays designed to find compounds that kill bacteria. Perspective: Synthetic biology revives antibiotics 2014-04-30T17:21:29.191Z What’s more, the researchers replicated the effect in another behavioral assay, called the open field test, which measures anxiety rather than pain. Male Researchers Stress Out Rodents 2014-04-28T19:55:00Z Caffeine is readily adsorbed by the body—free ethyl alcohol, too—but I'd want to see some in vivo assays on the complex before I decided. What Is the Big Deal about Powdered Alcohol? 2014-04-25T11:30:00Z Such experiments establish a baseline estimate for the impact of well-tolerated variants on the assay in question. Guidelines for investigating causality of sequence variants in human disease 2014-04-23T17:21:03.147Z One aliquot per sample was processed immediately for EM analysis to verify the quality of purification; the remaining aliquots were flash-frozen in liquid nitrogen and stored at −80°C for assay of complexII activity. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans 2014-04-04T22:52:36.299Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instruction. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z In addition, in vivo dilution xenotransplantation assays were performed in NOD/SCID/Il2rγ mice. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway 2014-04-04T18:28:18.449Z Proliferation assays of the individually barcoded cell lines verified that the barcodes did not affect cell proliferation in short term assays. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides 2014-04-04T14:06:22.655Z OpenBiome screens donors for infectious agents through 17 blood and stool assays; donors are also assessed for chronic conditions, such as metabolic syndrome, autoimmune disorders and digestive problems. Policy: How to regulate faecal transplants 2014-02-19T18:50:53.475Z All lifespan assays were conducted at 20°C unless otherwise indicated. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans 2014-04-04T22:52:36.299Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instruction. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z At best we should be able to defend the entire study, if required, or at least that part to which we contributed, e.g. statistical analysis, specific assays, etc. Leading European Cardiologist Accused Of Plagiarism 2014-02-10T14:11:00Z All compounds were diluted in the assay buffer and injected into the wells sequentially as indicated for each experiment. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides 2014-04-04T14:06:22.655Z The method it describes for checking the biological identity of the cells uses inappropriate cell-surface markers and no functional assay. Leaked files slam stem-cell therapy 2014-01-08T18:20:40.278Z Finally, we conducted photomorphogenesis assays in plant seedlings to place our findings in a physiological context. [Research Article] A Mechanism for Reorientation of Cortical Microtubule Arrays Driven by Microtubule Severing 2013-12-05T18:56:45.879Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instruction. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z Quality assurance procedures should include criteria for acceptance or rejection of assay batches and results from individual specimens. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z After selection, cells were removed from phenformin for at least 3 days before starting proliferation assays. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides 2014-04-04T14:06:22.655Z A delay in the retraction would waste the time of my colleagues who wanted to replicate our assays and build on our work. Lab Life: The Anatomy of a Retraction 2013-10-10T19:45:05.090Z Last year, a bioassay of this kind found androgens in 35% of freshwater samples tested, far more than chemical assays would suggest. Hormone Disruptors Rise from the Dead Like Zombies 2013-09-30T15:45:00.927Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instructions. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z Many omics tests are developed using data from retrospective studies in which these aspects of the assay were not standardized. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z Figure 1: Cancer cell fate versus potential. a, Transplantation assays assess the potential of cancer cells to form tumours. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z We have informed our colleagues of our results and he is remaking the strains. 2When laboratory members first established the pretreatment assay years ago, they included diverse controls to optimize the assays. Lab Life: The Anatomy of a Retraction 2013-10-10T19:45:05.090Z We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment. [Research Articles] A Molecular Signature Predictive of Indolent Prostate Cancer 2013-09-12T13:56:05.230Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instructions. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z Appropriate criteria will depend on the specimen type and the particular omics assay platform to be used. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z Figure 1: Cancer cell fate versus potential. a, Transplantation assays assess the potential of cancer cells to form tumours. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z This audit procedure would assess many of the fundamental components of scientific studies, such as appropriate statistical power; precision and accuracy of measurements; and validation data for assays and models. Research: A standard for policy-relevant science 2013-09-12T13:51:12.653Z A poles-to-tropics assay of sea urchins shows significant impacts on larvae. Dot Earth Blog: Papers Find Mixed Impacts on Ocean Species from Rising CO2 2013-08-26T15:51:27Z Cell viability was determined by CellTiter-Blue assay according to the manufacturer’s instructions. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z When multiple technicians or laboratories will conduct the assays, monitoring procedures should be in place to ensure comparability across technicians and laboratories. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z This raises the arresting possibility that tumours from different patients might require different assay conditions to determine their full spectrum of tumorigenic cells. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z To assay its worth, it’s instructive to compare U.S. aid to Pakistan, which was cut off in the 1990s after Islamabad was caught developing nuclear weapons. Obama Cancels Joint Military Exercise With Egypt 2013-08-15T16:05:22Z This error has no impact on the data presented in the Letter because they were representative images of clonogenic assays; the primary data presented in the main text and figures are unchanged. Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway 2013-07-24T17:21:28.743Z "The assays to tell whether bioprinting works are really, really time consuming and expensive." 3D printing human organs - but where's the money for it? 2013-07-17T12:30:00Z Intellectual property issues may apply to the use of the specimens, biomarkers, assays, and computer software used for calculation of the predictor. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z This will require systematically testing variations in xenotransplantation assay conditions, including the addition of variables such as human cytokines that might influence human-cell engraftment. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z Our work and the study of Bilican highlight the need for complementary assays to detect subtle phenotypic differences between control and mutant induced pluripotent stem cell lines. [Letters] Response to Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells" 2013-06-05T19:55:03.170Z Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations. [Letters] Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells" 2013-06-05T19:55:01.290Z The functionality of some promoters in was tested by transient expression assay. Architecture and evolution of a minute plant genome 2013-06-05T17:21:05.400Z The ultimate goal is to develop a more efficient, reliable and transparent process to move omics assays from promising research results to clinically useful tests that improve patient care and outcome. Criteria for the use of omics-based predictors in clinical trials 2013-10-16T17:22:00.073Z A transplantation assay might underestimate the frequency of cancer cells with tumorigenic potential for many reasons. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z Unfortunately, the approach was a little too new for the virtual model, says Kapeller, because CROs are set up to perform well-defined assays and protocols, not tackle innovative biology. Biotechnology: Virtual reality 2013-06-05T17:20:36.817Z If you talk now to the people in the pharmaceutical industry, what they will say is they’re moving massively away from target-based medicine to phenotypic assays. Harvard s Whitesides Gives Brilliant Critique of Mammoth U.S. Brain Project 2013-05-29T20:45:00.450Z Generation of synthetic vaccine seeds, together with more efficient vaccine release assays, would accelerate responses to influenza pandemics through a system of instantaneous electronic data exchange followed by real-time, geographically dispersed vaccine production. [Research Articles] Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics 2013-05-15T18:55:08.407Z So researchers at Genomic Health, the company that developed a gene-based test for predicting which breast cancers might recur, turned their attention to creating a similar assay for prostate cancer. The Genetic Test That Can Predict the Most Aggressive Prostate Cancers 2013-05-08T17:05:24Z It routinely redacts information about manufacturing details or quality assays, as well as protecting the identity of trial participants. European Court Wants Drug Data Kept Secret 2013-04-30T20:50:00Z The underlying bioscience uncertainty around the relevance and robustness of an assay or test for impacting/predicting outcomes isn’t any different than the uncertainty about whether a drug is pharmacologically active. Unhealthy Prognosis for Venture-Backed Diagnostics 2013-04-26T17:32:35Z The linear range of the ADH1 assay with respect to time was tested by reactions under standard assay conditions except varying the time up to 30min. High-level semi-synthetic production of the potent antimalarial artemisinin 2013-04-26T14:21:10.803Z Scheduled for launch in July, the test developed by Sample6 Technologies provides results in three to four hours, compared to 16 and 48 hours for current assays for bacterial contamination. Can Synthetic Biology Keep Your Food Safe? 2013-04-25T14:45:10.097Z The breast cancer assay, Oncotype Dx, provides women with a number between zero and 100 that indicates their risk of recurrence and their response to chemotherapy. The Genetic Test That Can Predict the Most Aggressive Prostate Cancers 2013-05-08T17:05:24Z Additionally, performance of the assay was evaluated on 21 blinded clinical specimens collected serially. [Research Articles] T2 Magnetic Resonance Enables Nanoparticle-Mediated Rapid Detection of Candidemia in Whole Blood 2013-04-24T18:25:05.913Z Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution. The African coelacanth genome provides insights into tetrapod evolution 2013-04-17T17:21:37.460Z That assaying of the record collection, an essential rite of familiarisation for teenagers of the 1970s and 1980s, is a vanishing custom in the era of Spotify. Fears over game microtransactions and the birth pangs of a post-stuff age 2013-04-15T08:00:04Z “People thought it was an artifact,” says Brian Kennedy, chief executive of the Buck Institute for Research on Aging in Novato, California, and one of the researchers who initially reported concerns about the assay. Red Wine's Link to Health Gains Support 2013-03-08T22:15:00.543Z The task he is undertaking now with the Linus Pauling Institute at Oregon State University is to run thousands of assays on key foods to establish the algorithms needed to develop a workable scanner. Organic versus Conventional: A Scanner May Say Which Is Healthier 2013-03-01T13:15:00.217Z The project is still in its early days — making sure that the same assay yields the same results in different labs. Big biology: The ’omes puzzle 2013-02-27T18:20:44.453Z A suspected false positive on a screening assay—designed to be highly sensitive but not very specific—is then followed up with testing by another technique. Drug screens-any more than theater? 2013-02-19T15:45:00.433Z They also tested the virulence of the two strains in human HeLa cells using an LDH release assay. Not all biofilms are equal: The hyper-biofilm of P. aeruginosa 2013-01-06T20:45:00.190Z The team's result was based on an assay that used a peptide bearing a tag that would fluoresce when the acetyl group was removed. Red Wine's Link to Health Gains Support 2013-03-08T22:15:00.543Z With this in hand, she was able develop assays to visualize how the venom acts both on red blood cells and in live animal models. Don't Pee On It: Zinc Emerges As New Jellyfish Sting Treatment 2012-12-12T23:15:00.223Z Eventually, however, those pathways could be used in cell-based assays to serve as bellwethers of toxicity. Big biology: The ’omes puzzle 2013-02-27T18:20:44.453Z Ten minutes of equilibrium time was allowed before the tubes were connected to the T-maze apparatus immediately before the assay. Non-synaptic inhibition between grouped neurons in an olfactory circuit 2012-12-11T21:22:02.810Z We demonstrate that some children with duplication also display variable immunological abnormalities that include reductions in memory T and B cells and natural killer cells and immunoglobulin assay responses. [Research Articles] Overexpression of Methyl-CpG Binding Protein 2 Impairs TH1 Responses 2012-12-05T19:55:11.953Z Second, cell and molecular biologists develop assays based on that pathway to screen libraries of small molecules for potential drugs. Drug discovery: A helping hand 2012-12-05T18:50:38.353Z They are cell-based assays looking at many, many, many different kinds of responses. Chemical "Soup" Clouds Connection between Toxins and Poor Health 2012-11-23T12:15:00.500Z Basically, to assess mineral content the geologists drill some holes and assay the ore for potash exploring percentage of mineral content as well as the thickness of the pay zone. How Arizona Is Helping America Reduce Dependence On Foreign Natural Resources 2012-11-06T16:43:07Z "It's really an assay for how your mind is built to tradeoff between different ways of living in the world," says psychologist Michael McCullough of the University of Miami in Coral Gables, Florida. Payback and Distrust: For Men, Rougher Childhoods Mean Less Cooperation 2012-10-31T01:10:00Z Furthermore, tissue architecture is generally not reflected in molecular assays, rendering this rich information underused. [Research Articles] Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling 2012-10-28T19:57:21.520Z Positive assays are followed by bioactivity-guided fractionation to isolate the active natural products with thin layer–, column-, and/or high-performance liquid chromatography. [Essay] IBI* Series Winner: Student-Directed Discovery of the Plant Microbiome and Its Products 2012-10-28T19:55:58.967Z In this study, a diverse set of breast tumours were assayed using six different technology platforms. Comprehensive molecular portraits of human breast tumours 2012-10-03T18:22:40.017Z Someday someone might discover the autoantibody that is the exclusive cause of COPD, and then the respective assay will be absolutely sensitive and specific for this disease. Perspective: Clues, not conclusions 2012-09-26T17:22:48.860Z But the ability to master a game or ace a psych test often doesn’t translate into better cognition when specific measures of intelligence are assayed later. Best Evidence for Brain Training Falls Short 2012-09-25T17:15:03.757Z Image processing also allowed us to describe and validate an independent prognostic factor based on quantitative analysis of spatial patterns between stromal cells, which are not detectable by molecular assays. [Research Articles] Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling 2012-10-28T19:57:21.520Z Time-kill assays were performed, measuring how many bacteria both compounds killed over time, and showing a decrease in the number of bacteria after 24 hours treatment with the compounds. Developing new antibiotic compounds: Dual-targeting inhibitors 2012-09-17T16:45:03.313Z In total, 800 patients were assayed on at least one platform. Comprehensive molecular portraits of human breast tumours 2012-10-03T18:22:40.017Z These data point to intricate cell-type-specific three-dimensional folding of chromatin. 3C-based assays detect specific and functional interactions, for example, TSSs with gene regulatory elements. The long-range interaction landscape of gene promoters 2012-09-05T17:22:23.563Z Bars indicate fold enrichment observed in transient assays in K562 relative to promoter-only control; mean of testing in both orientations is shown. The accessible chromatin landscape of the human genome 2012-09-05T17:21:47.670Z To capture a broader spectrum of biological diversity, selected assays were also executed on a third tier comprising more than 100 cell types including primary cells. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Most assays provide a single snapshot of cellular regulatory events, whereas a time series capturing how such processes change is preferable. Genomics: ENCODE explained 2012-09-05T17:21:10.890Z "In principle, the method holds great promise as a way of replacing the cumbersome melatonin assay," says Steven Brown, a molecular biologist at the University of Zurich in Switzerland. What Time Is it on Your Circadian Clock? 2012-08-27T20:10:00Z Colorimetric assays were used to identify artesunate, which turned yellow, from the fakes, which were colourless. Counterfeit Drugs: a Deadly Problem 2012-08-20T20:45:04.993Z Bars indicate fold enrichment observed in transient assays in K562 relative to promoter-only control; mean of testing in both orientations is shown. The accessible chromatin landscape of the human genome 2012-09-05T17:21:47.670Z We then trained the map using the signal of the 12 different ChIP-seq and DNase-seq assays in the six cell types analysed. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Both studies are based on the DNase I hypersensitivity assay, which detects genomic regions at which enzyme access to, and subsequent cleavage of, DNA is unobstructed by chromatin proteins. Genomics: ENCODE explained 2012-09-05T17:21:10.890Z In order to maintain fighting weight, an organisation must honestly assay its employees' contributions and cull the dead wood. How Microsoft's human resources culture drove away talent 2012-08-13T11:11:21Z A Mint spokesman said about 1 to 1.5 grams of each sample is destroyed in the assaying process, with the remaining granules returned to the government. Uncle Sam audits its stash of gold at New York Fed 2012-08-02T23:16:00Z It started when a graduate student falsified a cell-killing assay and fabricated data to support the mentor's favoured hypothesis. The roots of research misconduct 2012-08-01T17:50:51.720Z The classifications presented here are necessarily limited by the assays and cell lines studied, and probably contain a number of heterogeneous classes of elements. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Novavax said it is "evaluating both process and assay refinements" that it believes will further improve immune responses of its vaccine. Novavax experimental influenza vaccine meets main goal of study 2012-07-24T21:27:09Z The method was applied to generate such assays for more than 1000 cancer-associated proteins, which are functionally related to candidate cancer driver mutations. [Research Articles] Reproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics 2012-07-11T18:55:04.923Z The auditing team counted the U.S. stash, selecting more than 350 bars from which to extract samples for assaying. Uncle Sam audits its stash of gold at New York Fed 2012-08-02T23:16:00Z The former postdoc then left his biotechnology job, and the mentor rehired him, assigning him responsibility for the assay. The roots of research misconduct 2012-08-01T17:50:51.720Z This may be due to preferential capture of accessible alleles and/or the specific histone modification and transcription factor, assays used in the project. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z To assess the sensitivity of viruses to the NA inhibitor oseltamivir, NA inhibition assays were performed as described previously. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets 2012-06-20T17:22:43.540Z Through public access to the entire assay library, researchers will be able to target their cancer-associated proteins of interest in any sample type using the detectability information in plasma and urine as a guide. [Research Articles] Reproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics 2012-07-11T18:55:04.923Z A functional assay that exploits this ability of CD8 T cells would help identify such antigens. Perspectives: The missing pieces 2012-04-25T17:21:34.587Z After the postdoc left the lab to join a biotechnology company, the mentor assigned a new postdoc to perform the assay. The roots of research misconduct 2012-08-01T17:50:51.720Z However, many assays were performed on more than one cell type, allowing assessment of the rate of discovery of new elements. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z There are a crew of wretched souls That stay his cure: their malady convinces The great assay of art; but at his touch— Such sanctity hath heaven given his hand— They presently amend. The Doctor in History, Literature, Folk-Lore, Etc. 2012-04-25T02:01:14.613Z We used the assays to determine the detectability of the target proteins in two clinically relevant samples: plasma and urine. [Research Articles] Reproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics 2012-07-11T18:55:04.923Z Bratton et al used a luciferase assay, which allows you to link a luminescent protein to a piece of DNA to which the ER binds.. Experimental Biology Blogging: Using a chemical from slime mold to stop cancer spread 2012-04-23T15:15:08.813Z But the former postdoc would not show the new postdoc how he performed the assay. The roots of research misconduct 2012-08-01T17:50:51.720Z At this stage, we deliberately excluded RNA and methylation assays, reserving these data as a means to validate the segmentations. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z The bread about to be consumed is cut, and, in the presence of the “taker of assay,” is tasted, and the salt is also tested. The Doctor in History, Literature, Folk-Lore, Etc. 2012-04-25T02:01:14.613Z Even today, many researchers look askance at the Y2H assays used in the studies. Proteomics: The interaction map 2012-04-11T17:21:02.077Z This incident soon became known abroad, and the stone was assayed, the “gold finers” reporting it to contain a considerable quantity of gold. The Sea: Its Stirring Story of Adventure, Peril, & Heroism. Volume 3 2012-04-03T02:00:31.900Z Again and again he vainly assayed to speak; at length, drawing near, he bent his proud knee before her, and in agitated tones besought her pardon. Baron Bruno Or, the Unbelieving Philosopher, and Other Fairy Stories 2012-03-28T02:00:24.407Z We assayed chromosomal locations for up to 12 histone modifications and variants in 46 cell types, including a complete matrix of eight modifications across tier 1 and tier 2. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z It bore the innocent title of "An act revising and amending the laws relative to the mints, assay offices, and coinage of the United States." Money: Speech of Hon. John P. Jones, of Nevada, On the Free Coinage of Silver; in the United States Senate, May 12 and 13, 1890 2012-02-29T03:00:21.727Z In other words, the assay can identify weak, transient pairings such as those that perpetuate cell signalling. Proteomics: The interaction map 2012-04-11T17:21:02.077Z These include pharmacogenomics, in which specific genes that govern responses to medications are routinely assayed, and cancer treatments that probe tumors for specific genetic targets rather than relying on standard chemotherapy. Books: Genomics as a Final Frontier, or Just a Way Station 2012-02-27T19:31:00Z There is no freight to pay, no waiting for assays or analyses, and no settlements with mills or smelteries. The Business of Mining A brief non-technical exposition of the principles involved in the profitable operation of mines 2012-02-18T03:00:17.387Z We then trained the map using the signal of the 12 different ChIP-seq and DNase-seq assays in the six cell types analysed. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Be that as it might, the ordeal must be assayed. My Lords of Strogue Vol. III, (of III) A Chronicle of Ireland, from the Convention to the Union 2012-02-15T03:00:27.667Z Protein-fragment complementation assays, which can be conducted in yeast as well as mammalian cells, rely on reconstituting a wide range of 'reporters', often enzymes or fluorescent proteins. Proteomics: The interaction map 2012-04-11T17:21:02.077Z "My dear!" quoth the broad-shouldered but practical Tomoy�, as with one eye critically closed she assayed the temper of a brand new sword. The Curse of Koshiu A Chronicle of Old Japan 2012-02-14T03:00:23.467Z Such lots of ore will, no doubt, contain a great many chunks that would assay many times the average value. The Business of Mining A brief non-technical exposition of the principles involved in the profitable operation of mines 2012-02-18T03:00:17.387Z The advent of more powerful DNA sequencing technologies now enables whole-genome and more precise analyses with a broad repertoire of functional assays. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z In the past, variants had to be tested individually or in small batches, limiting assays to a few hundred. Functional genomics: The changes that count 2012-02-08T18:51:01.997Z In practice, this means repeating experiments using different types of assay and comparing the results with sets of controls. Proteomics: The interaction map 2012-04-11T17:21:02.077Z A. Post, internal revenue collector, furnishes the following resum� of the bullion product from January 1 to November 1, 1866, as assayed by different parties. A History of Oregon, 1792-1849 Drawn From Personal Observation and Authentic Information 2012-01-20T03:00:11.607Z The assay results obtained from the collected samples inform the superintendent just "how the stuff is holding up" throughout the mine and he governs his work accordingly. The Business of Mining A brief non-technical exposition of the principles involved in the profitable operation of mines 2012-02-18T03:00:17.387Z What launched that golden orb his course to run, What wrecks his firm foundations, when 'tis done, No man of science ever weighed with scales, Nor made assay with touchstone, no, not one! The Sufistic Quatrains of Omar Khayyam 2012-01-08T03:00:15.553Z Stan Fields, a molecular geneticist at the University of Washington in Seattle, is designing assays that exploit the basic principle of natural selection. Functional genomics: The changes that count 2012-02-08T18:51:01.997Z Conditions of the assays are adjusted to boost detection of positive controls without raising the detection of random interactions. Proteomics: The interaction map 2012-04-11T17:21:02.077Z The procedure in the examples above referred to consist in pouring crude petroleum on vegetable fiber or wood shavings and firing it, collecting the ashes and making the usual fire assay. Scientific American, Vol. XXXIX.?No. 24. [New Series.], December 14, 1878 A Weekly Journal Of Practical Information, Art, Science, Mechanics, Chemistry, And Manufactures 2012-01-05T03:00:31.783Z The shortcoming of conventional troponin assays with low sensitivity within the first hours after chest pain onset led to the evaluation of various so-called early biomarkers in the diagnosis of MI. Study Finds Role For New Troponin Test in Diagnosis of MI 2011-12-27T21:07:36Z It gave us absolutely no confidence in the ability of the major labs involved to do the assays. In a Rare Move, Science Without Authors' Consent Retracts Paper That Tied Mouse Virus to Chronic Fatigue Syndrome 2011-12-22T16:16:13Z “You can come up with all sorts of assays,” says Fields, “and the answer comes down to a simple sequence run.” Functional genomics: The changes that count 2012-02-08T18:51:01.997Z As part of a framework put forth in Nature Methods, results from interaction studies should be confirmed in different types of assays. Proteomics: The interaction map 2012-04-11T17:21:02.077Z The green and magenta lines show the analyses of control assays lacking enzyme and NADP, respectively. [Report] The Tricarboxylic Acid Cycle in Cyanobacteria 2011-12-15T18:56:34.097Z “The reliable detection of very low troponin concentrations using these new highly sensitive assays in the acute setting might pose a challenge in everyday clinical practice.” Study Finds Role For New Troponin Test in Diagnosis of MI 2011-12-27T21:07:36Z This method, called serial transplantation, is a functional assay that is still the standard for demonstrating two essential properties of cancer stem cells: the capacities to recapitulate the original tumour and to self-renew. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z But of course such assays prove nothing, for the accidental presence of a grain of gold in the sample would make all the difference in the results. The Inhabitants of the Philippines 2011-11-23T03:00:21.653Z Yeast two-hybrid assays can probe hundreds of thousands of potential protein interaction pairs a week. Proteomics: The interaction map 2012-04-11T17:21:02.077Z |
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