| 单词 | metastasis |
| 例句 | But that was many years ago, when fears of recurrence and metastasis stalked my mind night and day. The Out of Towner: Cancer Survivors See the Play ?Wit? 2012-02-16T23:10:38Z These mystery ventures, a drooping eyelid, the fight to find a word — or, conversely, the sudden concern over an oil pipeline in Seattle, suggested brain metastasis. What he said before he died 2013-01-29T01:00:00Z But underneath the skepticism, something else nagged at me: the sense that my incertitude was a metastasis of our jittery, gaslit world, where baseline reality is increasingly in dispute. The Cell, the Spell and the Mystery of ‘Sea Wall/A Life’ 2019-08-27T04:00:00Z Three days before my father’s surgery, his chest x-ray revealed metastasis in his lungs. When I parented my father 2013-03-04T23:57:00Z It was after her diagnosis with secondary metastases of the bone in May that year that she started a blog, www.writtenoff.net, where she described her experiences and feelings as she underwent a number of debilitating treatments. Eleanor Jeffery obituary 2012-06-28T11:20:03Z Typical sites for renal cell metastasis include the brain and the bones. When I parented my father 2013-03-04T23:57:00Z We read of “a slow boil in the bones,” of a “morphine moon” and “opiate hope” and the “mad metastasis of Now.” Edward Hirsch’s ‘Gabriel’ and Christian Wiman’s ‘Once in the West’ 2014-09-09T04:00:00Z There are the familiar expressions: Stage IV, metastases, remission, cure. This Life: Cancer Survivors’ Celebrate Their Cancerversary 2013-12-06T23:53:09Z Forced to explain the joke, he said that among oncologists, “mets” is a term for “metastases,” which, um, apparently always win. Perspective | What happens when a humor columnist discovers a lump in his throat 2017-03-24T04:00:00Z "The disease is gender inequality. And all these things are the metastases of the primary tumor." Banned 'India's Daughter' fiilmmaker brings her work to the U.S. 2015-03-10T04:00:00Z The metastasis causes these patients to eventually succumb to the disease, which is why researchers are focused on understanding the biology of metastatic pancreatic cancer. Pancreatic cancer discovery opens the door for new clinical trial 2023-11-16T05:00:00Z Another problem: Advanced tumors -- and their metastases -- cannot be completely removed. Nanoparticles for optimized cancer therapy 2023-11-15T05:00:00Z The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. Mechanics of breast cancer metastasis discovered, offering target for treatment 2023-10-27T04:00:00Z TV star Suzanne Somers died of “breast cancer with metastasis to the brain,” according to a report citing her death certificate. Suzanne Somers' cause of death revealed 2023-10-27T04:00:00Z "The protein is involved in the formation of immunosuppressive tumor microenvironments. Therefore, we found that our vaccine is much more effective at reducing metastasis, and not in reducing the growth of the primary tumors." Nanoparticle vaccine could curb cancer metastasis to lungs by targeting a protein 2023-10-18T04:00:00Z Although it can usually be cured with surgery, it can cause severe hypertension or it can spread and develop into metastases. Genetic code of rare kidney cancer cracked 2023-09-25T04:00:00Z In patients with cancer, this increases the likelihood of metastasis, through which the cancer spreads to other parts of the body. New drug delivery system has potential to improve cancer treatments 2023-09-20T04:00:00Z Like in the two-dimensional model, the researchers found in the three-dimensional model that dynein was "indispensable" in the spread or metastasis of cancer cells. Mechanics of breast cancer metastasis discovered, offering target for treatment 2023-10-27T04:00:00Z Although researchers have recognized that CAFs play a role in metastasis, they do not understand which signals are involved in the process. New insight into crosstalk between cancer cells and their environment 2023-09-19T04:00:00Z Another set of experiments demonstrated the vaccine's potential to offer protection against cancer metastasis after surgical removal of the primary tumor. Nanoparticle vaccine could curb cancer metastasis to lungs by targeting a protein 2023-10-18T04:00:00Z Scientists have discovered a new type of stem cell that gives rise to the backbone — and that helps to drive the frequent metastasis of breast tumours and other cancers to the spine. Newfound Stem Cell Might Explain How Breast Cancer Spreads to the Spine 2023-09-14T04:00:00Z Jain says normalizing tumor vessels may provide another benefit—reining in metastasis, the spread of tumor cells to other parts of the body. Failed cancer therapy revived as powerful tumor killer when combined with newer drugs 2023-05-16T04:00:00Z Marlies, 66, had successful surgery to remove the brain metastases, four days after the ER visit and was home on Christmas Day, according to Frei. Sounders’ Stefan Frei shares his mother’s inspiring message after cancer diagnosis 2023-03-27T04:00:00Z Without treatment, men in the active-monitoring group were nearly twice as likely to see their prostate cancer progress and spread — or form what’s known as metastases — than the men in the aggressive treatment groups. Some men with prostate cancer can avoid, delay harsh treatments, study finds 2023-03-12T05:00:00Z When injected subcutaneously, the vaccine stimulated the immune system in mice to produce antibodies against S100A9, effectively reducing the protein levels and minimizing cancer metastasis to the lungs. Nanoparticle vaccine could curb cancer metastasis to lungs by targeting a protein 2023-10-18T04:00:00Z The authors’ finding made them wonder whether the new type of stem cell could account for some of the unexplained patterns in cancer metastasis. Newfound Stem Cell Might Explain How Breast Cancer Spreads to the Spine 2023-09-14T04:00:00Z "Despite chemotherapy, his neuroendocrine prostate cancer progressed resulting in multifocal brain metastases and a likely paraneoplastic ascending paralysis leading to his death." US cancer patient developed 'uncontrollable' Irish accent 2023-02-16T05:00:00Z The text told recipients they had "aggressive lung cancer with metastases", a type of secondary malignant growth. Doncaster surgery sends cancer text instead of festive message 2022-12-29T05:00:00Z This surprised the researchers, according to Hamdy, who said it suggests that “if men develop metastases, that doesn’t necessarily mean they will die of prostate cancer” — though they may die of other causes. Some men with prostate cancer can avoid, delay harsh treatments, study finds 2023-03-12T05:00:00Z Higher levels of Candida in gastrointestinal tumour cells were linked to more gene activity that promotes inflammation, a higher rate of metastasis and lower survival rates, the researchers found. Fungi Lurk Inside Cancers—and Might Speed Their Growth 2022-10-03T04:00:00Z The cells accumulate mutations, proliferate uncontrollably, and can migrate to different parts of the body through a process called metastasis. Biology for AP Courses 2022-06-09T00:00:00Z This largely explains why the liver is the most common site for the metastasis of cancers that originate in the alimentary canal. Anatomy and Physiology 2013-06-19T00:00:00Z Fighting a metastasis in her bones, she says she fears for other women as doctors seek to avoid legal reprimands for recommending abortions. Protesters stand against abortion ban in Texas, first to enact laws 2022-06-25T04:00:00Z Scientists know a lot about the molecular steps required for implantation—and “it would be nice to employ that line of pharmacological thinking for metastases.” Insights from Pregnancy Could Help Fight Cancer 2022-06-09T04:00:00Z He didn’t find any of these odd growths, but he ordered a CT scan to look for metastases. He Could Barely Walk, and He Was Seeing Double. What Was Wrong? 2022-02-16T05:00:00Z The extracellular matrix connects the cell to the external environment and ensures correct positioning of the cell to prevent metastasis. Biology for AP Courses 2022-06-09T00:00:00Z Aggressive forms of prostate cancer, in contrast, involve metastasis to vulnerable organs like the lungs and brain. Anatomy and Physiology 2013-06-19T00:00:00Z At the oncologist’s recommendation, Drayton underwent radiation targeted at the metastases in his spine, but the treatment showed no improvement. For a bicyclist, a long overdue checkup uncovered the unexpected 2021-06-18T04:00:00Z “The fight against Iran and its metastases and against Iranian armament is a huge task,” Prime Minister Benjamin Netanyahu said in a meeting with Israeli security chiefs. Amid tensions with Iran, Pentagon chief says alliance with Israel is ‘ironclad’ 2021-04-11T04:00:00Z I believe his deceitful attacks on the election results, and by extension on the Constitution he swore to uphold, were the metastasis of his moral deficiencies and psychological disorders. Opinion | George Conway: What I really believe 2021-01-19T05:00:00Z But the metastasis of it, all the thousands of cancer cells throughout the body, they're still there. Author and radio host Thom Hartmann on the "struggle for democracy" and the road ahead 2020-11-16T05:00:00Z A second paper reported that the bacterium induces changes in gene regulation that boost metastasis to the lungs in mice. Deadly Spread of Some Cancers May Be Driven by a Common Mouth Microbe 2020-09-28T04:00:00Z Finally, the authors addressed the question of whether metastasis to the lymph nodes occurs before that to other locations because exposure to lymph induces a protective metabolic make-up that allows melanoma cells to spread. Cancer cells stock up in lymph vessels to survive 2020-08-18T04:00:00Z Importantly, the authors found an association between higher levels of NET DNA in the blood of people with early-stage breast cancer and subsequent metastasis of the cancer to the liver. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z That is, these tumors reinitiate an earlier developmental process to bring about invasive metastasis, dispersing the cancer and making it very hard to treat. Close-Up Views of Tumors Reveal a New Cancer Biology 2020-04-21T04:00:00Z The scaffolds might even slow the spread of some metastases by stopping circulating cancer cells in their tracks. Research round-up: Cancer diagnosis 2020-03-24T04:00:00Z A third study determined that the abundance of F. nucleatum in human colon cancer tissue correlates with the amount of metastases and, in mice, identified additional signals by which the microbe may “orchestrate” metastasis. Deadly Spread of Some Cancers May Be Driven by a Common Mouth Microbe 2020-09-28T04:00:00Z Cancer spread, or metastasis, is an inefficient process6,7, and many cancer cells die in the bloodstream. Cancer cells stock up in lymph vessels to survive 2020-08-18T04:00:00Z Interestingly, the role of the interaction between CCDC25 and NET DNA in supporting metastasis in the lungs might occur only in the context of infection, whereas its effect on liver metastasis might occur spontaneously. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z His University of Pavia lab studies synapse formation as well as collagen production and its possible implications in cancer metastasis. Labs go quiet as researchers brace for long-term coronavirus disruptions 2020-03-13T04:00:00Z Tumour spread from its primary site to distant organs, which is called metastasis, involves complex interactions between cancer cells and the surrounding healthy tissues. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Researchers also showed that the infection promotes growth of both primary tumors and metastases in mouse models of breast cancer. Deadly Spread of Some Cancers May Be Driven by a Common Mouth Microbe 2020-09-28T04:00:00Z When such cancer cells then enter the bloodstream from lymph nodes, this lipid helps the cells avoid ferroptosis, increasing the formation of metastases compared with the case for cancer cells that don’t enter lymph vessels. Cancer cells stock up in lymph vessels to survive 2020-08-18T04:00:00Z When ILK was removed or its downstream signalling partner, the protein β-parvin, was disabled, cancer-cell growth and motility in vitro were substantially impaired and, in mice, metastasis to the liver was reduced. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z Virtual digital spaces, artificial intelligence, corporations superseding nation states, extreme body modification, and the insane metastasis of the marketing and branding industries ... William Gibson: ‘I was losing a sense of how weird the real world was' 2020-01-11T05:00:00Z Such secondary tumours, or metastases, are often lethal. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Even a third of women whose cancer is detected early will face recurrence or metastasis — and metastatic disease remains incurable. Review | From brutal surgeries to pink ribbons: A history of breast cancer 2019-12-13T05:00:00Z She compared it to “a slow-motion metastasis that is echoing across the political establishment, the economy, and society.” Could Iran’s Revolution Unravel Over a Four-Cent Price Hike? 2019-12-06T05:00:00Z Yang et al. show that the ability of NET DNA to foster metastasis to the liver was not specific to breast cancer cells. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z This spreading process, known as metastasis, typically involves cellular stressors and environmental shocks that induce dramatic changes in cancer cells. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z Efficient metastasis of breast cancer cells to the lung in mice requires the participation of a type of myeloid cell called a monocyte1,4. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z When cancer spreads from its primary site to become established at a secondary location, this process, termed metastasis, is often fatal. Survival skills ensure that cancer spreads 2019-09-03T04:00:00Z This is a knotty problem, in the late stages of metastasis, but a wider crisis should be avoided. Opinion | America faces a critical test in its relationship with Turkey 2019-07-17T04:00:00Z The authors found that if human breast and colon cancer cells were engineered to increase their levels of CCDC25, this helped to fuel liver metastasis in mice given such cells. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z Using WGS, the authors produced a rich catalogue of the genetic mutations found in each metastasis. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z Previous work1,4 indicates that neutralizing a protein called CCL2, which is produced by the tumour and promotes monocyte accumulation in the lungs of mice, impairs metastasis in mouse tumour models. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z The timing of metastasis initiation varies depending on the size, stage and differentiation status of the tumour at the primary site1. Survival skills ensure that cancer spreads 2019-09-03T04:00:00Z Cancer becomes lethal when tumour cells spread from their primary site in the body to invade distant organs — a process termed metastasis. Metabolic signal curbs cancer-cell migration 2019-06-25T04:00:00Z Yang and colleagues’ findings represent a key advance in efforts to curb cancer spread, and might lead to the development of a specific strategy to halt NET boosting of cancer metastasis. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z As the cancer evolves, it acquires further mutations that enable it to spread to other sites in the body through the blood — a process called metastasis. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z Consistent with previous studies4,5, the authors found that two types of myeloid cell — monocytes and neutrophils — accumulated in the lung before metastases were detectable there. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z The general factors that affect tumour growth provide clues to why cellular adaptations occur during metastasis. Survival skills ensure that cancer spreads 2019-09-03T04:00:00Z For this complex event to occur, the cells must invade their surrounding tissue, enter the bloodstream and colonize another location, where secondary tumours called metastases form. Metabolic signal curbs cancer-cell migration 2019-06-25T04:00:00Z Moreover, the data presented point to a possible way to predict metastasis to the liver by monitoring NET DNA in the blood. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z Furthermore, larger DNA aberrations such as structural variations and WGD are significantly more common in metastases in most cancer types. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z The impaired recruitment of tumour-promoting monocytes and neutrophils to the lungs was accompanied by a decrease in the number and size of metastases. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z In-depth analyses are nevertheless needed, because the genetic background of a given type of tumour might affect the requirements for metastasis to occur. Survival skills ensure that cancer spreads 2019-09-03T04:00:00Z Writing in Nature, Wang et al.2 identify a previously unknown mechanism by which a molecule generated in cellular metabolism inhibits the induction of EMT and thereby restrains the metastasis of lung cancer in mice. Metabolic signal curbs cancer-cell migration 2019-06-25T04:00:00Z Some think that the supposed addictive properties of social media make this metastasis inevitable for many people. Opinion | Social media should be a complement to real life. Not a substitute. 2019-06-14T04:00:00Z Future clinical studies of metastasis are likely to consider liquid biopsies as an alternative collection method. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z The absence of Rb resulted in loss of cellular differentiation and an increase in the spread of cancer cells to other sites in the body through a process called metastasis. Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets 2019-04-30T04:00:00Z Understanding how E-cadherin expression is stabilized might reveal a vulnerability of cancer cells on a path towards metastasis. Survival skills ensure that cancer spreads 2019-09-03T04:00:00Z Many people assume that when cancer shows up following an earlier tumor, it is a metastasis from the first. Unraveling why some people get not one, not two, but many cancers 2019-04-12T04:00:00Z Although metastasis is usually the main reason for the failure of cancer treatment and for eventual death, it is a remarkably inefficient process. Molecular envoys pave the way for pancreatic cancer to invade the liver 2019-03-05T05:00:00Z As a result, the chance of hitting tumor suppressors and oncogenes, and genes that favor metastasis or drug resistance, becomes much higher, accelerating cancer development. A New Idea about How Cancer Begins 2019-03-01T05:00:00Z The authors observed that the molecular changes that lead to progression and metastasis in this lung cancer model are strikingly different, depending on whether Rb is present or absent. Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets 2019-04-30T04:00:00Z Papa then turned her attention to how platelets drive metastasis. These platelet ‘decoys’ could prevent blood clots without spreading cancer 2019-02-13T05:00:00Z Disrupting these clusters might offer a way of fighting metastasis. Daily briefing: How to make the most of Instagram 2019-02-07T05:00:00Z Whether the neutrophils remain associated with the cancer cells until they form such a metastasis is unknown. Sticking together helps cancer to spread 2019-02-05T05:00:00Z Since not all tissues express the same genes, I hypothesize that different targets act locally to initially start cancer, and later during metastasis and treatment resistance. A New Idea about How Cancer Begins 2019-03-01T05:00:00Z Can you picture the process of metastasis, the spread of cancerous cells through the body? How deaf researchers are reinventing science communication 2018-12-11T05:00:00Z The mysteries of metastasis, the intractability of anxiety disorders and strange new diseases of blood cells kept our brains and souls alive when the hospital was asking us to punch numbers into terminals. For Doctors, Delving Deeper as a Way to Avoid Burnout 2018-10-10T04:00:00Z “If you give checkpoint inhibitors for brain metastases from melanoma or lung cancer, you can see regression,” says Donald O’Rourke, a neurosurgeon at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z The authors found that in vitro exposure of mouse breast cancer cells to IL-1β and IL-6 increased their capacity to form lung metastases in mice. Sticking together helps cancer to spread 2019-02-05T05:00:00Z “Especially for cancer patients, a delay of even a few days in treatment may cause metastasis.” Defying Erdogan, Turkey’s Central Bank Raises Interest Rates 2018-09-13T04:00:00Z A bright, restless mind, Soon-Shiong is now seeking to remedy a very different source of malignant metastasis: news. The billionaire who bought the LA Times: 'Hipsters will want paper soon' 2018-07-21T04:00:00Z When leukaemia spreads into the CNS, this process, termed metastasis, is mainly limited to the region known as the subarachnoid space, which contains cerebrospinal fluid that bathes the brain and spinal cord. Leukaemia follows a blood-vessel track to enter the nervous system 2018-07-17T04:00:00Z In mice with the brain metastases, about half survived for several weeks after the cell therapy — evidence that engineered rehoming tumor cells might be therapeutic. CRISPR Makes Cancer Cells Turncoats that Attack Their Tumor 2018-07-12T04:00:00Z The process that determines whether cancer spreads from the original tumour site to reach distant organs is poorly understood, despite the devastating consequences for disease prognosis if this spreading step, termed metastasis, occurs. Sticking together helps cancer to spread 2019-02-05T05:00:00Z They show tumor progression, metastases and cancer deaths are significantly lower in men treated with open surgery. Is Robotic Prostate Surgery Better Than Traditional Surgery? 2018-06-25T04:00:00Z It was the well-funded metastasis of extreme Saudi religious intolerance — its Wahhabi orthodoxy — into forms of murderous Islamist hatred of the apostate West. Opinion | The Prince Who Would Remake the World 2018-06-21T04:00:00Z I believe that fake news is the cancer of our times and social media the vehicles for metastasis. A note to readers from Patrick Soon-Shiong 2018-06-17T04:00:00Z Those metastases, not the original tumor, are responsible for upwards of 90 percent of cancer deaths. CRISPR Makes Cancer Cells Turncoats that Attack Their Tumor 2018-07-12T04:00:00Z For cancer to invade other tissues and form metastases, tumour cells must travel through the body, including the bloodstream. Sticking together helps cancer to spread 2019-02-05T05:00:00Z Few studies have reported meaningful data on recurrence, metastasis or prostate cancer-specific death rates with robotic prostatectomy. Is Robotic Prostate Surgery Better Than Traditional Surgery? 2018-06-25T04:00:00Z So it's recurrence and metastasis weren't detected until he, too, was crippled by pain. Why Was Her Vision Jerky and Blurry if There Was Nothing Wrong With Her Eyes? 2018-05-01T04:00:00Z However, unfortunately many ultimately develop resistance and metastases. How Cancer Can Become Therapy-Resistant 2018-04-07T04:00:00Z Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary sites1. Asparagine bioavailability governs metastasis in a model of breast cancer 2018-02-06T05:00:00Z Figure 1 | Interactions between breast cancer cells and neutrophils promote the formation of lung metastases. Sticking together helps cancer to spread 2019-02-05T05:00:00Z The highest level of evidence for open prostatectomy comes from randomized clinical trials showing that open surgery significantly reduces metastases and prostate-cancer deaths. Is Robotic Prostate Surgery Better Than Traditional Surgery? 2018-06-25T04:00:00Z Because the combination destroys other tumors besides the injected one, it might eliminate metastases, or the secondary tumors that result when cancer spreads, he says. Injection helps the immune system obliterate tumors, at least in mice 2018-01-31T05:00:00Z They found that metastasis occurred at a steady rate for the 15 years after the end of the treatment period. A rude awakening from tumour cells 2018-01-28T05:00:00Z A combination of differential expression and focused in vitro and in vivo RNA interference screens revealed candidate drivers of metastasis that discriminated metastatic clones. Asparagine bioavailability governs metastasis in a model of breast cancer 2018-02-06T05:00:00Z Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes 2018-01-23T05:00:00Z When mice with metastatic tumours in their lungs inhaled the nanoparticles, growth of the metastases slowed, raising hopes for future lung-cancer treatments. A sweet pill turns deadly for tumours 2018-01-22T05:00:00Z Genetic suppression of chromosomal instability markedly delays metastasis even in highly aneuploid tumour models, whereas continuous chromosome segregation errors promote cellular invasion and metastasis in a STING-dependent manner. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z We wonder, however, whether this approach will be sufficient to reduce or avoid the risk of late metastasis. A rude awakening from tumour cells 2018-01-28T05:00:00Z A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Asparagine bioavailability governs metastasis in a model of breast cancer 2018-02-06T05:00:00Z Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes 2018-01-23T05:00:00Z Two months after he left the hospital, S. returned to see me with sprays of metastasis in his liver, his lungs and, unusually, in his bones. This Cat Sensed Death. What if Computers Could, Too? 2018-01-03T05:00:00Z Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z To best determine other possible ways to reduce the risk of relapse, we must consider what might cause the dormant tumour cells from which metastasis arises to reawaken after many years. A rude awakening from tumour cells 2018-01-28T05:00:00Z The increased criminality of today is the “metastasis” of that cancer, he said. Mexico: Latest murder highlights blurred lines in journalism 2017-12-31T05:00:00Z As many as half of all women with metastatic HER2-positive or triple-negative breast cancer will develop one or more brain metastases as their disease progresses. Cancer clinical trials exclude many desperate patients. Should that change? 2017-12-15T05:00:00Z The authors show that tumours growing in high oxygen settings, such as lung cancers or metastasis, usually show elevated NSF1 signalling. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis 2017-11-21T05:00:00Z Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer 2017-11-07T05:00:00Z Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z Cancer can move from a localized tumour to remote locations — a process called metastasis. Cancer biology still needs physicists 2017-10-23T04:00:00Z But even a partial slaughter would inhibit metastasis. Microscopic lasers may stop tumours spreading around the body 2017-08-31T04:00:00Z The spread of cancer around the body is a crucial moment called metastasis. Spreading cancer caught on film - BBC News 2017-07-05T04:00:00Z Researchers randomly assigned 1,939 melanoma patients with lymph node metastases to lymph node removal or continued observation using ultrasound. With Melanoma, Lymph Node Removal May Not Improve Survival 2017-06-07T04:00:00Z Notably, CSCs are critical for the formation and maintenance of liver metastasis derived from colorectal cancers. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer : Nature : Nature Research 2017-03-28T04:00:00Z Without a better way to explain and treat metastases, new clinical methods will do little to improve the situation. Cancer biology still needs physicists 2017-10-23T04:00:00Z These are cells that have broken off a primary tumour and which, if left unchecked, might lodge in various parts of the body and turn into secondary cancers, a process called metastasis. Microscopic lasers may stop tumours spreading around the body 2017-08-31T04:00:00Z However, if mice were treated with diphtheria toxin, the metastatic liver tumours were substantially reduced, indicating that Lgr5+ cells are required to initiate metastasis. Cancer: Tumour stem-cell surprises : Nature : Nature Research 2017-03-28T04:00:00Z The spread of cancer - known as metastasis - is a fight between a rapidly mutating cancer and the rest of the body. Cancer spread cut by 75% in tests - BBC News 2017-01-11T05:00:00Z Unfortunately, our subcutaneously transplanted tumours never led to the development of metastasis. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer : Nature : Nature Research 2017-03-28T04:00:00Z Since the centres launched, there has been greater recognition of the potential contributions of physical forces to cancer-cell responses, such as the number and location of metastases, or how cells stick together. Cancer biology still needs physicists 2017-10-23T04:00:00Z D’Amico advises that men who wish to avoid metastases should consider monitoring, rather than surgery or radiation, only if their life expectancy is less than a decade. The Most Notable Medical Findings of 2016 2016-12-29T05:00:00Z Although it remains to be determined whether this finding will also hold for metastases that develop in tissues other than the liver, these results underscore the general importance of stemness for metastasis in colorectal cancer. Cancer: Tumour stem-cell surprises : Nature : Nature Research 2017-03-28T04:00:00Z With regard to the “metastasis of the cancer of ISIL, Southeast Asia clearly is a place they aspire to be spreading,” Defense Secretary Ashton Carter said in September. Philippines emerge as ‘jihad of choice’ after Obama phases out counterterrorism operation 2016-10-26T04:00:00Z Lastly, we evaluated the requirement of Lgr5+ CSCs for the maintenance of established liver metastasis, as patients with metastatic disease currently have a poor prognosis and represent an important unmet medical need. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer : Nature : Nature Research 2017-03-28T04:00:00Z She also continues to conduct research on tumor metastasis and Ewing sarcoma, a bone cancer. Scientist ‘a powerful voice’ on Cancer Moonshot Initiative 2016-10-21T04:00:00Z However, some of the challenges have remained particularly troubling, such as the most deadly impact from osteosarcoma: the metastasis of tumor cells into the lungs. How Treating Cancer in Canines Is Advancing Human Medicine 2016-10-06T04:00:00Z The authors' work indicates that the elimination of Lgr5+ cells might be an approach worth testing for the treatment of liver metastases, suggesting an exciting avenue for future investigation. Cancer: Tumour stem-cell surprises : Nature : Nature Research 2017-03-28T04:00:00Z For a while, his surgeon sat on the fence – although the primary abdominal cancer was technically operable he had a hunch that the tiny, indeterminate nodules on the lung represented metastases. To sustain hope while preserving honesty is the greatest challenge in oncology | Ranjana Srivastava 2016-09-27T04:00:00Z Before 2005, most patients who presented with distant metastases survived for less than one year. Perspective: What next for treatment? : Nature : Nature Research 2016-09-13T04:00:00Z He and his colleagues are among the first in the country to use the MRI-guided laser system Visualase to treat inoperable tumors including glioblastoma and high-grade gliomas and metastases to the brain from elsewhere. In Need of Brain Breakthroughs 2016-09-12T04:00:00Z How that metastasis happens, and if it can be stopped, are the targets of two studies our team is tackling in veterinary patients right now. How Treating Cancer in Canines Is Advancing Human Medicine 2016-10-06T04:00:00Z The metastasis of Pentagon spending shows no sign of abating. Not the Candidate of Peace 2016-08-09T04:00:00Z They hope to find clues to metastasis, the way cancer spreads through the body. Cancer Is Contagious Among Clams. What About Us? 2016-06-22T04:00:00Z There is no way of screening for kidney cancer to detect primary tumours or metastases early. Perspective: What next for treatment? : Nature : Nature Research 2016-09-13T04:00:00Z Vasculogenic mimicry may also promote metastasis, the migration of tumor cells to new parts of the body, which is responsible for most cancer deaths. Tumors have found a bloody new way to grow and spread 2016-06-16T04:00:00Z And metastases that sometimes appear many years after the excision of a primary tumour would be caused by quiescent CSCs that have wandered to distant sites. Cancer therapy: Defining stemness : Nature : Nature Publishing Group 2016-06-07T04:00:00Z “Law enforcers are dealing with the metastases, but not the main tumor.” Lure of Amber Pits Ukraine’s Illegal Miners Against State 2016-06-03T04:00:00Z For people with a large number of metastases, the model suggested that three therapies would be needed. Cancer therapy: an evolved approach 2016-04-12T04:00:00Z They also were less prone to metastases, even if scientists injected some of the cancer cells into their lungs to stimulate metastases. How Exercise May Lower Cancer Risk 1456-10-14T05:00:00Z “To my knowledge, this is the first time we’ve discovered that a process that promotes metastasis provides a selective benefit to the primary tumor,” Hannon says. Tumors have found a bloody new way to grow and spread 2016-06-16T04:00:00Z According to a court filing, Rigas, 91, suffers from terminal Stage IV bladder cancer with metastases to the lungs, with a life expectancy of six months or less. U.S. says dying Adelphia founder should be released from prison 2016-02-19T05:00:00Z In a delirious state, brought on by fever, brain metastases or end-stage changes in body chemistry, circadian rhythms are severely disordered, so the patient may not know whether he is awake or dreaming. A New Vision for Dreams of the Dying 2016-02-02T05:00:00Z The team examined not only the primary tumour, but also the satellite tumours — called metastases — that had spread throughout the patients' bodies. Cancer therapy: an evolved approach 2016-04-12T04:00:00Z “We are extremely worried about the metastasis of Isil in a number of locations, Libya being just one of those locations,” Cook said. US considering fresh military action in Libya over Isis threat 2016-01-27T05:00:00Z The barcodes allowed the researchers to track metastases to their ancestral cells. Tumors have found a bloody new way to grow and spread 2016-06-16T04:00:00Z Conventional accounts trace the metastasis of the federal government not to what came before Roosevelt’s election but to what came after. Prohibition and the Penal State 2015-12-21T05:00:00Z A team from Germany now reports that a new audio-visual imaging technique looks as effective as surgery for identifying melanoma metastasis. Could a Scan Someday Replace Lymph Node Biopsy? 2015-12-10T05:00:00Z Even if a cancer seemed localized to the breast at the time of detection and treatment, there were probably invisible metastases elsewhere in the body. Why did the American Cancer Society ignore evidence about early detection until now? 2015-10-23T04:00:00Z Cook acknowledged that the “metastasis” of Isis beyond its primary base in Iraq and Syria has prompted the Pentagon to revisit the question of a renewed war in Libya. US considering fresh military action in Libya over Isis threat 2016-01-27T05:00:00Z Deutsch believes that surgery "can really make a difference in the patients with GI tract metastases. The operation can be performed laparoscopically, so it is minimally invasive." Surgery May Raise Survival With Advanced Melanoma: Study 2015-10-08T04:00:00Z In their 2014 lung cancer study they also found that antioxidant supplements caused lung tumor cells to turn off the activity of a well-known cancer-suppressing gene called p53; its inactivation is believed to drive metastasis. Antioxidants May Make Cancer Worse 2015-10-07T04:00:00Z She later enrolled in a test of Keytruda, which melted away the brain metastases and most of the lesions on her liver. Immunotherapy’s Promise Against Cancer 2015-10-06T04:00:00Z It was contrived in 1889 by the English surgeon Stephen Paget, who found that the spreading of tumors to other places in the body, a process called "metastasis," does not occur randomly. Missing the Soil for the Seeds in Cancer Research 2015-09-18T04:00:00Z He will get stereotactic radiation to the brain — a long-standing treatment for brain metastases — and the best available drugs, she said. Jimmy Carter reveals his cancer is melanoma. What is melanoma? 2015-08-20T04:00:00Z Local defeats of Islamist groups, followed by their flight, are accelerating a continental metastasis. Jihafrica 2015-07-16T04:00:00Z In addition, metastases from systemic cancer to the brain are 10 times more common than primary malignancy of the brain. A Ray of Hope for Patients With Malignant Brain Tumors 2015-06-24T04:00:00Z The study included almost 300 patients with brain metastases and blood clots. Blood Thinners OK for Cancers That Spread to Brain, Study Finds 2015-06-02T04:00:00Z Those, brain metastases, are far more common than is primary brain cancer. On The Death Of Beau Biden, Brain Cancer, Progress And Hope 2015-06-02T04:00:00Z "Stereotactic radiation was used originally for brain metastasis – cancer spread to the brain – where the accuracy needed to be within a millimeter," Katz says. Radiation: Evolving Choices in Cancer Treatment 2015-05-22T04:00:00Z CIM is trying to extend the lives of Cuba's cancer patients by broadening the use of therapeutic vaccines, designed to rouse the immune system so that it attacks the tumor, curtailing growth and metastasis. Feature: Graying Cuba strains socialist safety net 2015-05-14T04:00:00Z For example, Sendurai Mani, a pioneer in cancer metastasis and genomics at the University of Texas MD Anderson Cancer Center, laments that he is constantly searching for bioinformaticians — those who analyse such data. Core services: Reward bioinformaticians 2015-04-07T04:00:00Z Within a week, a surgeon found a neuroendocrine tumor in the pancreas and metastasis in the liver. Doctors Take the Lead in Right-to-Die Lawsuits 2015-04-02T04:00:00Z "The study of her remains shows the typical destructive damage provoked by the extension of a breast cancer as a metastasis," he said in a statement on Tuesday. Oldest evidence of breast cancer found in Egyptian skeleton 2015-03-24T04:00:00Z I rejoice when I meet gifted young people — even the one who biopsied and diagnosed my metastases. Oliver Sacks Reveals Terminal Cancer in New York Times Op-Ed 2015-02-19T05:00:00Z When a person dies from cancer, the culprit is usually not the original tumor but rather the cancerous cells that spread throughout the body and replicate in distant organs, a process called metastasis. Nanoparticle drug stops cancer’s spread in mice 2015-01-22T05:00:00Z He and colleagues performed CT scans on 10 patients to check the size of their metastases, or tumor colonies spawned by the original growth. Cancer paradox: Testosterone injections combat lethal prostate tumors 2015-01-07T05:00:00Z The treatments, begun in December 2013, shrank the tumor and eliminated the metastases. Medical Mysteries: Cancer patient was given no hope, but fought anyway 2014-12-19T05:00:00Z In September, he suffered a seizure in Mexico and was rushed back to Boston, where his doctors found a brain metastasis. Here's One Great Act of Holiday Kindness 2014-12-09T05:00:00Z But since there was only one metastasis in one lobe of her lung, she insisted. Beating the Odds: Cancer Survivors’ Success Stories 2014-12-09T05:00:00Z A former graduate student with liver metastases was offered two ways to deal with a stomach swollen by ascites, the accumulation of fluid in the abdominal cavity produced by cancer cells. Living With Cancer: Difficult Choices 2014-08-07T04:00:00Z David Zaharoff, an assistant professor of biomedical engineering and the principal investigator for the project, says metastasis - not a patient’s primary tumor - kills about 90 percent of cancer patients. Ark. university awarded $1.5M for cancer research 2014-07-22T04:00:00Z Based on her response to chemotherapy and her overall good condition, Suntha believed it was worth trying radiation in an effort to eradicate the tumor and wipe out any lingering metastases. Medical Mysteries: Cancer patient was given no hope, but fought anyway 2014-12-19T05:00:00Z It’s these metastases that often prove fatal to people with cancer. Wanted: cure for fatal effects of radiation 2014-05-13T04:00:00Z Intravital imaging studies showed that macrophages, along with tumour cells and endothelial cells, form a structure that pumps tumour cells into the bloodstream — a key step in metastasis. Imaging: Cancer caught in the act 2014-05-07T17:20:20.854Z Brain metastases present one of the poorest prognoses for cancer patients, and their rate of incidence is increasing. Cancer: Disabling defences in the brain 2014-04-04T18:22:59.003Z The process, called metastasis, appears to be driven by the same mechanism used in the embryo to dispatch freshly created cells to their proper locations. Raw Data: A Tumor, the Embryo’s Evil Twin 2014-03-17T20:26:20Z Her response was deemed excellent: The metastases shrank significantly and no new tumors appeared. Medical Mysteries: Cancer patient was given no hope, but fought anyway 2014-12-19T05:00:00Z Stopping metastasis would thus be a great achievement. Cancer: Secondary goals 2014-02-13T15:59:49Z In a study of 60 people with breast cancer, individuals with a higher density of these pumps in their tumours were more likely to develop metastases in other organs. Imaging: Cancer caught in the act 2014-05-07T17:20:20.854Z Fortunately, metastasis is a highly inefficient process: fewer than 0.01 of cells that leave a primary tumour are able to colonize and grow in other organs. Cancer: Disabling defences in the brain 2014-04-04T18:22:59.003Z "About 90% of cancer deaths are related to metastases," said lead researcher Prof Michael King. 'Sticky balls' stop cancer spreading 2014-01-07T01:24:51Z The most interesting potential application of single-cell metabolomics may be in the area of cancer—for example, identification of circulating cancer cells that lead to metastasis. [Special Issue Review] Single-Cell Metabolomics: Analytical and Biological Perspectives 2013-12-05T18:56:42.368Z That may, eventually, result in less metastasis, fewer secondaries and longer lives for patients. Cancer: Secondary goals 2014-02-13T15:59:49Z Cancer cells hijack this process, first to enable metastasis through activating the EMT program and then, once they reach their new home, to revert back to epithelial form by activating the MET program. The Hallmarks of Cancer 6: Tissue Invasion and Metastasis 2013-10-30T23:15:03.320Z Moreover, might targeting certain PA proteins, such as tissue PA or urokinase PA, be an effective approach by which to combat metastasis, especially given that these are already targets of interest for anticancer therapy? Cancer: Disabling defences in the brain 2014-04-04T18:22:59.003Z Words like stage four and metastasis sounded surreal. The rumination on what isn't 2013-09-25T17:20:49.573Z However, disseminated cancer cells that remain after 'curative' surgery exhibit extreme genomic heterogeneity before the manifestation of metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z One of the mysteries of metastasis is why migrant cells from different sorts of primaries prefer to set up home in particular types of secondary tissue. Cancer: Secondary goals 2014-02-13T15:59:49Z They are thought to persist in tumors as a distinct population of cells and cause relapse and metastasis by forming new tumors. The Hallmarks of Cancer 6: Tissue Invasion and Metastasis 2013-10-30T23:15:03.320Z Successful outgrowth of tumours and eventual metastasis is not determined solely by genetic alterations in tumour cells, but also by the fitness advantage such mutations confer in a given environment. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z In these cases, cancer stem cells are thought to drive tumour growth and disease progression, perhaps through therapy resistance and metastasis. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z Figure 3Early steps of metastasis at ectopic sites in bone marrow. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Although our sample size was small and all participants had early-stage cancer with low risk of metastasis, we believe large, randomized trials to test the validity and applicability of our results are warranted.” No, Dean Ornish And Elizabeth Blackburn Have Not Discovered The Fountain Of Youth 2013-09-16T22:30:00Z These distant settlements of cancer cells are named metastases and, with the exception of leukemias and some brain tumors, cause the majority of cancer deaths. The Hallmarks of Cancer 6: Tissue Invasion and Metastasis 2013-10-30T23:15:03.320Z The major cause of cancer-associated mortality is tumor metastasis, but our understanding of this process is far from complete. [Perspective] Circulating Tumor Cells 2013-09-12T17:56:31.020Z To what extent do metastasis, therapy resistance and disease progression reflect the intrinsic properties of cancer stem cells as opposed to genetic evolution or other sources of heterogeneity? Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z Moreover, they often have little or no benefit when given to at-risk patients with no metastasis, that is, as adjuvant therapy. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z A topical solution of Miltefosine is approved for treatment of skin metastases from breast cancer. Where's the Real Danger from Infection This Summer? 2013-08-27T17:15:00.313Z It proved to be a metastasis from a malevolent form of uterine cancer, one whose cells are atypically aggressive and prone to spreading. Books: ‘The Cancer Chronicles’ Wanders Through the Disease’s World 2013-08-26T18:05:52Z Curing it, then, was assumed to be a matter of finding and cutting out a tumor before that metastasis happens. Our Feel-Good War on Breast Cancer 2013-04-27T01:21:08Z For instance, a kidney cancer patient with bone metastases, Smart Patients might direct you to conversations going on about cabozantanib, a drug for bone metastases in other diseases being developed by Exelixis. A Former Google Exec Aims To Power A Patient Revolution 2013-04-24T14:38:49Z One limitation of the literature on metastasis is that findings are readily included without acknowledgement of the relevance and limitations of patient- and model-derived data. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Combined, these findings implicate KLF6-SV1 as a key driver of breast cancer metastasis that distinguishes between indolent and lethal early-stage disease and provides a potential therapeutic target for invasive breast cancer. [Research Articles] KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival 2013-01-23T19:55:09.013Z At present the only defense against dying from breast cancer is early diagnosis and treatment before metastasis. Letters: Questions and Answers (2 Letters) 2013-01-07T21:11:13Z Nearly everyone agrees there is significant work to be done at both ends of the diagnostic spectrum: distinguishing which D.C.I.S. lesions will progress to invasive disease as well as figuring out the mechanisms of metastasis. Our Feel-Good War on Breast Cancer 2013-04-27T01:21:08Z He says existing studies point to a remarkable ability of CBD to arrest cancer cell division, cell migration, metastasis, and invasiveness. Could pot stop breast cancer? 2012-11-26T21:57:00Z This Perspective concentrates on human metastasis by attempting to derive an evolutionary concept of cancer based on patient-derived molecular and clinical data, focusing on the early evolution of systemic cancer. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Solid tumours shed cells that enter the bloodstream and travel to other parts of the body, where they can take hold, forming metastases. Diagnostics: Playing detective 2012-11-23T15:21:10.310Z “Ninety percent of cancer deaths are caused by metastases,” says Bhatia. Nanotechnology: Carrying drugs 2012-11-23T15:20:59.170Z Consider that two metastases from the same primary tumour are growing in the same organ yet respond differently to the same drug, he says. Oncology: Getting physical 2012-11-23T15:20:46.620Z In 2011, the American Society for Radiation Oncology, a trade group, published guidelines to help doctors reduce the number of treatments for patients with bone metastasis. "Irrational" factors may drive end of life access to radiation 2012-11-21T22:05:50Z For all carcinomas, patients initially present with local lymph node metastases in the absence of distant metastasis far more frequently than vice versa. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z We show that melanomas from 25 patients exhibited reproducible differences in the rate of spontaneous metastasis after transplantation into NSG mice and that these differences correlated with clinical outcome in the patients. [Research Articles] Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients 2012-11-07T20:25:11.993Z But to do this well, he says, mutations need to be linked with more information, such as when and where metastases occurred and how effective the drugs were. Trio of Genome-Sequencing Studies Offer a Broader View of Lung Cancer 2012-09-13T21:45:00.287Z It also led to a kind of metastasis. The Challenge of Mexico's Next President: The Corruption at the Heart of Crime 2012-07-05T20:05:34Z Tumors resembled human neuroblastomas in morphology, metastasis pattern, gene expression, and the presence of neurosecretory vesicles as well as synaptic structures. [Research Articles] Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice 2012-07-04T18:25:08.700Z However, other studies have found higher similarity between primary tumours and paired metastases or relapsing cancers. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z So on June 17, at the opening keynote talk at the Model Organisms meeting, I felt a stab when Bert Vogelstein said, “about 3,000 resistant cells are present in every visible metastasis.” 4 Suggestions for Halting the Lethality of Cancer 2012-06-26T16:15:07.857Z Dz13 inhibited tumor growth in both immunodeficient and immunocompetent syngeneic mice and reduced lung nodule formation in a model of metastasis. [Research Articles] DNAzyme Targeting c-jun Suppresses Skin Cancer Growth 2012-06-20T18:55:16.347Z Here, we treated patients with a single cycle of intravenous reovirus before planned surgery to resect colorectal cancer metastases in the liver. [Research Articles] Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients 2012-06-13T18:55:08.080Z There is a huge barrier to developing agents that prevent breast cancer metastasis. Perspective: The right trials 2012-05-30T17:51:10.087Z Explanations for why some primary tumours and metastases are more closely related than others are manifold. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z “The chance that a single cell in a metastasis has 2 genes mutant that can confer resistance is exponentially less than they’d have one,” he said, adding that using combinations of treatments is nothing new. 4 Suggestions for Halting the Lethality of Cancer 2012-06-26T16:15:07.857Z Some will grow into metastases immediately; some will do so much later. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z Further, ME009 represented a metastasis from a primary melanoma of a patient with a clinical history of chronic ultraviolet exposure. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z In primary prevention trials, the end point would be the time to development of the first metastasis. Perspective: The right trials 2012-05-30T17:51:10.087Z Clinical details, such as the time interval between primary tumour resection and biopsy or surgery of the metastasis, or the type and extent of systemic treatment are often omitted. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Unfortunately, for most of the patients with brain metastases, the response to the drug was limited to several months. GSK melanoma drug shows promise in early trial 2012-05-18T00:38:35Z The graph that troubles Chambers most, however, is the one for patients with local breast cancer who show no evidence of metastasis at diagnosis. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z In a parallel study we sequenced four primary neuroblastoma tumours as well as cell lines derived from these tumours and their metastases. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z This design must incorporate preclinical and clinical data in a rational manner and measure end points that are appropriate for metastasis prevention. Perspective: The right trials 2012-05-30T17:51:10.087Z Cancers with explosive growth at primary and distant sites might result from aggressive, highly similar clones, whereas metastases arising after long latency periods may differ extensively. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Results of Phase I trial published in The Lancet medical journal showed substantial shrinking of tumors in patients treated with the drug, dabrafenib, and showed promise against secondary melanoma tumors, or metastases, in the brain. GSK melanoma drug shows promise in early trial 2012-05-18T00:38:35Z To some extent, she adds, the location of metastases is determined by the patterns of blood flow that carry cells away from the primary tumour. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z A third study, published in Lancet Oncology, looked at findings from observational studies and found that regular use of aspirin reduced the long-term risk of several cancers and prevented the metastasis of tumors. Aspirin, the Wonder Drug: Studies Show It Could Help Prevent Cancer 2012-03-21T23:06:23Z Moreover, successful prevention of metastasis is likely to require a combination of metastasis-preventive drugs, given the number of pathways involved in this process and the potential for tumour cells to mutate. Perspective: The right trials 2012-05-30T17:51:10.087Z Figure 4: Heterogeneity of metastasis and homogenization by systemic therapies. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z However, the brain metastases disappeared in four of the patients when they were treated with 150 milligrams of dabrafenib twice daily. GSK melanoma drug shows promise in early trial 2012-05-18T00:38:35Z Others think that liver metastases grow from CTCs that travelled directly to the liver and then became dormant. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z He speaks of a metastasis to the kidneys and bladder being peculiarly favorable in empyema. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Most people with breast cancer die as a result of tumour metastases, either directly or indirectly. Perspective: The right trials 2012-05-30T17:51:10.087Z The time course of metastasis suggests that metastases have similar growth rates to primary tumours. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Two of the 10 brain metastasis patients who received the drug survived for more than 12 months. GSK melanoma drug shows promise in early trial 2012-05-18T00:38:35Z A negative result is great news: the patient is very unlikely to develop bone metastases. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z Beck made fourteen experiments very carefully, but did not succeed in producing metastasis in a single case. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The result was that the tumour cells never formed a distant lesion — in other words, the compound prevented metastasis formation. Perspective: The right trials 2012-05-30T17:51:10.087Z In summary, benign lesions share DNA methylation changes, restricted loss of heterogeneity and multiple oncogenic mutations with malignant lesions, but they are insufficient to predispose lesions to invasion and metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z If operation is deferred, metastases of the tumour will have occurred, and operation will be too late. Essays In Pastoral Medicine 2012-03-05T03:00:09.993Z In one interpretation, says Sledge, tumour cells are actively dividing, but a barrier prevents them from crossing the threshold to overt metastasis. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z The most satisfactory explanation of their presence, and of the generalization, recurrence, or metastasis of tumors, is derived from what has already been stated with reference to the manner of the growth of the latter. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The most important end point would be the time until a new metastasis occurs — not shrinkage of an existing tumour. Perspective: The right trials 2012-05-30T17:51:10.087Z If cellular diversity correlates with benign and malignant states, and if increasing diversity indices are associated with the propensity to seed colonies at ectopic sites, what is the role of diversity in metastasis? Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z "There is no metastasis, just this small lesion in the same place where they removed the tumor," the 57-year-old president said, adding that he was in good physical condition. Ch?vez to Undergo Cancer Operation 2012-02-22T02:38:41Z If we wait until there’s pain or metastases we rarely cure the disease.” Obama s War on Alzheimer s: Will We Be Able to Treat the Disease by 2025? 2012-01-31T20:45:24.440Z This metastasis occurs much more frequently in males than in females, and is usually met with in pubescents and adults, being very rare either in childhood or old age. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The end point would be the time to development of a new metastasis. Perspective: The right trials 2012-05-30T17:51:10.087Z Additional layers of diversity are generated by clonal expansion, microevolution and phenotypic plasticity. c, Relative stability of M1/PT-like genomes after manifestation of metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Well, this Mr. Loudon is a practical fellow; and his metastasis is admirable. Dealings with the Dead, Volume I (of 2) 2012-01-17T03:00:17.977Z Dr DePinho refers to it, jokingly, as metastasis, since a clone of his primary creation will be taking root elsewhere in the country. Cancer research: Take five 2011-12-28T16:03:36Z Dupuytren failed to produce metastasis by injections of pus into the veins of dogs; these results were confirmed by Boyer, who only obtained metastasis when he used ichorous pus in his experiments. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z According to further examinations yesterday, “there is no metastasis and the conclusion is that the illness is isolated in the gland,” Scoccimarro said. Argentina President Fernandez to Have Surgery for Thyroid Cancer 2011-12-28T03:37:01Z Furthermore, sequencing studies revealing genomic heterogeneity in primary tumours and metastases suggest that several attractor states may exist for a given cancer. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z According to tests conducted today, “there is no metastasis and the conclusion is that the illness is isolated in the gland,” Scoccimarro said. Argentina’s Fernandez to Undergo Surgery for Thyroid Cancer 2011-12-28T01:29:39Z That would be one benign sort of metastasis. Cancer research: Take five 2011-12-28T16:03:36Z When metastasis occurs, the return of fever calls for the same general treatment as in the early stage of parotitis. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z “Even devils with large tumors and metastases continued to produce motile sperm of similar quality to disease-free animals and to those with early-stage tumors.” Sperm Bank and Reproductive Research Could Help Save Tasmanian Devils from Extinction 2011-12-15T00:45:09.280Z In its defining ability to spread is the potential seed of metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z In the summer of 2011, it entered clinical trials to treat multiple myeloma with bone metastases. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z At the top, the long-lived cancer stem cells can renew themselves indefinitely and replenish bulk tumour cells, generate new tumours, and cause metastasis and relapse. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z The melanoma tumour cell lines used in this study were derived from primary cutaneous melanomas or melanoma metastases, as described previously. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma 2011-11-30T18:21:18Z Inhibition of CMA delays xenograft tumor growth, reduces the number of cancer metastases, and induces regression of existing human lung cancer xenografts in mice. [Research Articles] Chaperone-Mediated Autophagy Is Required for Tumor Growth 2011-11-16T19:55:33.430Z Although the occurrence of early dissemination and the existence of DCCs with immature DCC-M0-like genomes are increasingly accepted, the relevance of these cells as seeds of metastasis is questioned and negated. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z The other medicine, GRN1005, is being tested against brain metastases stemming from non-small cell lung cancer as well as from breast cancer. Geron Ends Stem-Cell Therapy Work Citing Cost of Research 2011-11-15T17:46:44Z But the point of cancer stem-cell therapy is to prevent relapse and metastasis and to prolong survival — all outcomes that could take lengthy, large-scale clinical trials to demonstrate. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z "With help from bone marrow stem cells, they may then spread via the blood stream to set up metastases at other sites." Novartis drug may help older breast cancer patients 2011-09-25T12:06:13Z Delcath's new drug application of the treatment was based on its other late-stage trial data of melanoma metastases and did not include this extra study, he said. Delcath says colorectal cancer treatment not effective 2011-09-01T14:06:38Z It may be impossible to prove the cells' relevance in patients because the founder cell of a metastasis may never be identified and DCC-M0-like genomes may be outcompeted and disappear once M1/PT-like genomes emerge. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z At the study's outset, 31 percent of low- and medium-risk patients received CT scans and 28 percent got bone scans, looking for signs of metastasis. Peer feedback cuts doctors' over-use of tests 2011-08-05T21:53:37Z "Look at something as straightforward as 'where does metastasis occur?'" says Davies. Physics meets cancer: The disruptor 2011-06-01T17:20:30.187Z The relative risk for developing metastases, or secondary tumors, outside bone during treatment with Zometa was approximately halved in the postmenopausal women compared with the younger patients. Novartis drug may help older breast cancer patients 2011-09-25T12:06:13Z When any one of these three organs is not functioning at its best, extra work is thrown upon the others, and in some extreme cases this metastasis, or transference of function, is very remarkable. The Gospel Of Evolution From "The Atheistic Platform", Twelve Lectures 2011-05-31T02:00:36.420Z Therefore, metastasis models based on cell lines model metastatic processes that occur in end-stage metastatic patients. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Only the end may be somewhat open to doubt, with its metastasis of the heroine's character,—unless indeed we consider the sweeping change accounted for by the theory of duplex personality. Prophets of Dissent : Essays on Maeterlinck, Strindberg, Nietzsche and Tolstoy 2011-05-17T02:00:20.900Z "Whether this process is mandatory for metastasis to occur is still unclear," says Isaiah Fidler, a cancer biologist at the M. D. Anderson Cancer Center in Houston, Texas. Tumour biology: Cancer theory faces doubts 2011-04-20T17:20:26.967Z Depending on your perspective, Mr. Trump’s growing visibility on television and in political news stories over the last few weeks represents the opening phase of a political campaign or the metastasis of a media spectacle. Trump for President in 2012? Maybe. Trump for Trump? Without Question. 2011-04-02T22:16:47Z Meanwhile, researchers are still sorting out the basic biology of cancer development, such as how it spreads into other organs of the body, a process called metastasis. Is the "war on cancer" winnable? 40 years after the unofficial declaration, the disease is spreading throughout the globe 2011-03-24T21:15:05.667Z If the progression of DCCs with DCC-M0-like genomes is important for human metastasis and if the progression provides a time window for intervention, what are the underlying mechanisms? Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z The show includes targeted cancer therapy, progress with cancer genomes, mechanisms of metastasis, immunity's role in cancer, and more. [Podcast] Science Podcast 2011-03-24T18:57:17.833Z Instead, he and others suggest that metastasis occurs when mutations in cancer cells compromise cell–cell adhesion. Tumour biology: Cancer theory faces doubts 2011-04-20T17:20:26.967Z In their experiments, they showed that blocking the enzyme LOXL2 prevented metastasis. Blocking enzyme cut cancer spread 2011-02-22T05:47:06Z Finding cancer in those nodes indicates that disease cells have migrated and could cause metastases elsewhere. Breast cancer finding may change treatment 2011-02-14T19:49:04Z In both cases, cell fitness is sensed and communicated, and variation of both could play a part in metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Cancer’s spread, or metastasis, to other parts of the body is one of the main reasons cancer kills, says Khalid Sossey-Alaoui, a cancer biologist at the Cleveland Clinic’s Lerner Research Institute. Running a Cancer Roadblock 2011-02-04T16:02:00Z Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. [Research Articles] Stromal Endothelial Cells Directly Influence Cancer Progression 2011-01-19T22:55:12.407Z He developed metastasis in his liver—and only in his liver—and that was able to justify transplantation. How Might Steve Jobs' Liver Transplant Be Affecting His Health? 2011-01-19T11:15:00.193Z Since it is metastasis that ultimately kills, some advocates want more resources devoted to its study and treatment. A Pink-Ribbon Race, Years Long 2011-01-17T21:56:42Z Primary tumour exosome secretions may even evoke the 'education' of tissues such as bone marrow resulting in the long-lasting promotion of metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z A mastectomy, several courses of chemotherapy, discovery of liver metastases, and a slow and lingering progression to death ensued. Early testing key to cancer drive 2011-01-12T18:19:17Z There were sporadic reports of "scalp metastasis," success rates with the early caps were low, and ice caps fell out of favor. Breast cancer patient uses super-chilled headgear to try to retain her hair 2011-01-11T00:46:10Z Two independent studies of lung metastasis in mice converge on this theme. Editors' Choice 2011-01-05T01:55:01.267Z Even though many cancer drugs are initially tested on patients with advanced disease, Danny Welch, an expert on metastasis, says only a few hundred scientists in the world are trying to understand the process. A Pink-Ribbon Race, Years Long 2011-01-17T21:56:42Z Using a different statistic, the risk of bone metastasis or death was reduced 15 percent. Amgen Drug Slows Spread of Cancer but Doesn?t Extend Life 2010-12-14T05:50:04Z Doses of bisphosphonates given to treat cancer patients with bone metastasis are typically 10 times higher than doses used in patients with osteoporosis. Bisphosphonates tied to stroke in cancer patients 2010-10-12T14:27:00Z The development is encouraging because secondary tumors, or metastases, in the brain are a major problem in the deadly form of skin cancer. New melanoma drug may shrink brain tumors 2010-10-10T09:05:00Z Tumor metastases are a major cause of death from solid tumors. Editors' Choice 2011-01-05T01:55:01.267Z In the past, melanoma metastases were all treated about the same, he says. New Drug Fights Metastatic Melanoma 2010-08-26T17:46:00Z To answer your question, sometimes surgery can be helpful in reducing the pain from bony metastases. Easing the Pain of Lung Cancer 2010-07-20T19:49:00Z He was classified with stage 4 and has metastases in his lymph glands. Expert Answers on Pancreatic Cancer Treatment 2010-06-17T18:20:00Z Use in primary liver cancer as well as metastases from other types of cancer could put the sales potential at $5.6 billion. Delcath cancer drug delivery system aids survival 2010-06-05T22:30:00Z It is important that we detect metastases early in order to ensure the patient is getting the appropriate treatment. MRI scans accurately spot spread of cancer: study 2010-05-06T22:07:00Z By sheltering such a salient offender at its very heart, the Vatican had invited the metastasis of the horror into its bosom and thence to its very head. The Pope Should Be Questioned in Sex-Abuse Cases 2010-04-24T02:11:00Z Also, in some cases, chemotherapy will cause dramatic reduction in the pain from bone metastases, with a concomitant reduction in the size of the metastatic deposits. Easing the Pain of Lung Cancer 2010-07-20T19:49:00Z A lesser but significant percentage of patients succumb to complications of predominantly local disease related to the pancreas and surrounding structures and have a lesser burden of metastases. Expert Answers on Pancreatic Cancer Treatment 2010-06-17T18:20:00Z When cancer cells migrate to other parts of the body, and start growing, a process known as metastasis, the likelihood of successful treatment begins to fall. Beta-blockers 'cut cancer spread' 2010-03-26T12:47:00Z Remember what I told you in the bar about metastasis? Cancer World "Is suffering under metastasis migratory gout, it may be termed changing from articular to large organic structures." The Daltons, Volume I (of II) Or,Three Roads In Life It is this which makes metastasis such an important element in the malignancy of tumors. Special Report on Diseases of Cattle Besides these he describes a case of lymphosarcoma of the neck with metastases in the bone-marrow, in which an unexampled increase of the white blood corpuscles, and especially of the eosinophil cells was found. Histology of the Blood Normal and Pathological The biological processes which trigger metastasis are still not fully understood. Beta-blockers 'cut cancer spread' 2010-03-26T12:47:00Z When fever exists first, and terminates in dropsy, who has proved, that there existed no local irritation producing the fever, and that the hydropic irritation has not supervened by metastasis. North American Medical and Surgical Journal, Vol. 2, No. 3, July, 1826 Stanzas we were at first profane enough to attribute to Metastasio, but afterwards found that it was only the metastasis of his metre adapted to the use of the church. Blackwood's Edinburgh Magazine, Volume 59, No. 363, January, 1846 On the other hand, a malignant tumor in its primary growth may so implicate a vital organ as to destroy life before metastasis can occur or even before cachexia can develop. Special Report on Diseases of Cattle The unreliability and incorrectness of this terminology is best illustrated by another form of leukæmic metastasis. Histology of the Blood Normal and Pathological In the 43 who were taking beta-blockers, there was a significant reduction in both cancer metastasis, and new tumours within the breast. Beta-blockers 'cut cancer spread' 2010-03-26T12:47:00Z After such free removal these tumours show little tendency to recur and metastases are rare. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. Thus when the liver is torpid, a perpetual uneasiness and depression of spirits occur; which a fit of gout is supposed to cure by a metastasis of the disease. Zoonomia, Vol. II Or, the Laws of Organic Life The compress, without the pack, would be apt to cause a metastasis to a vital organ. Hydriatic treatment of Scarlet Fever in its Different Forms The conditions in myelogenic leukæmia are quite similar, for foci of myeloid tissue may appear in the spleen or lymph glands according to the kind of metastasis. Histology of the Blood Normal and Pathological I have thought that its origin might be accounted for on the principle of metastasis of morbid material. Report on Surgery to the Santa Clara County Medical Society The submaxillary salivary glands and the cervical lymph glands are usually implicated, and the disease tends to spread by metastasis to distant parts. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. The most common are concussion, overexertion, exhaustion, rapid changes of temperature, ingestion of certain feeds, purgatives, and the oft-mentioned metastasis. Special Report on Diseases of the Horse The gills have become shifted forward by a metastasis similar to that which brought the whole thoracic organs far forward in fish. Form and Function A Contribution to the History of Animal Morphology Bearing in mind that in none of the other 39 cases were myelocytes demonstrated, one does not hesitate to explain their presence in the blood in this single case by the metastases in the bone-marrow. Histology of the Blood Normal and Pathological New growths which originate in the skeleton are spoken of as primary tumours; those which invade the bones, either by metastasis from other parts of the body or by spread from adjacent tissues, as secondary. Manual of Surgery Volume First: General Surgery. Sixth Edition. The neighbouring lymph glands are infected early, but metastases to other organs are not common. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. The sinapism will draw the current of the circulation to the exterior, the metastasis to the lungs or intestines is prevented, and the enfeebled nervous system is stimulated to renewed vigor by the peripheral irritation. Special Report on Diseases of the Horse A further application of the hypothesis of metastasis will be noticed below in connection with the determination of the sternum of fishes. Form and Function A Contribution to the History of Animal Morphology In the same category of laminitis from metastasis may also be placed the laminitis occurring as a result of an overdose of aloes. Diseases of the Horse's Foot After all symptoms have settled down, but not till then, for fear of exciting relapse or metastasis, the joint is massaged and exercised. Manual of Surgery Volume First: General Surgery. Sixth Edition. Clinically, the induration and fixation of the tumour suggest its epitheliomatous character, but the absence of a primary growth in the mouth or pharynx excludes its being a metastasis in the lymph glands. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. In rare cases the mucous membrane of the nostrils may also become affected, showing yellowish flat elevations and ulcerations, and these may extend by metastasis to internal organs. Special Report on Diseases of the Horse We note here an interpretation of the first metastasis in terms of functional adaptation. Form and Function A Contribution to the History of Animal Morphology Ackerman has spoken of metastasis of the tears, and Dixon gives an instance in which crying was not attended by the visible shedding of tears. Anomalies and Curiosities of Medicine The joint lesions may be the only evidence of metastasis, or they may be part of a general infection involving the endocardium, pleura, and tendon sheaths. Manual of Surgery Volume First: General Surgery. Sixth Edition. The lymph glands become enlarged after the tumour bursts through the capsule; and metastases to the lungs and bones, particularly the skull, sternum, and mandible, are common. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. Such 'metastases,' such transferences of sensation, are recognised by science. A Desperate Character and Other Stories And these metastases are due to functional requirements—for example, the forward position of sternum and thoracic organs in fish is an adaptation to swimming. Form and Function A Contribution to the History of Animal Morphology Autenreith mentions metastasis of milk through an abdominal abscess to the thigh, and Balthazaar also mentions excretion of milk from the thigh. Anomalies and Curiosities of Medicine Secondary cancer is a comparatively common disease, and, as in metastases in other tissues, the secondary growths resemble the parent tumour. Manual of Surgery Volume First: General Surgery. Sixth Edition. Attesting to the spreading of the rot throughout the Karadjordjevicean state, was its cancerous metastasis through all levels of the army and the government. Terrorists and Freedom Fighters The result was a repulsive malignant metastasis of capitalism, devoid of the liberal ideals or practices, denuded of ethics, floating in a space free of functioning, trusted institutions. After the Rain : how the West lost the East It is important to note this hypothesis of a "metastasis" which Geoffroy makes, for it is the key to the understanding of many of the far-fetched homologies which he tries to establish. Form and Function A Contribution to the History of Animal Morphology Gardane speaks of metastasis to the lungs, and there is another case on record in which this phenomenon caused asphyxia. Anomalies and Curiosities of Medicine The cancers most liable to give rise to metastasis in bone are those of the breast, liver, uterus, prostate, colon, and rectum; hyper-nephroma of the kidney may also give rise to metastases in bone. Manual of Surgery Volume First: General Surgery. Sixth Edition. Medical science has applied the term metastasis to such spreading and reappearing of malignant tumors after extirpation. Nature Cure Its removal by operation is usually contra-indicated, but we have known of cases terminating fatally in which the section revealed only one metastasis, the removal of which would have benefited the patient. Manual of Surgery Volume First: General Surgery. Sixth Edition. Although these tumours have been known to give rise to metastases, they are, as a rule, innocent and are to be treated as such. Manual of Surgery Volume First: General Surgery. Sixth Edition. There is the history of a woman who suffered from metastasis of milk to the stomach, and who, with convulsive action of the chest and abdomen, vomited it daily. Anomalies and Curiosities of Medicine In all of these conditions, examination of the bones with the X-rays gives valuable information and often disclose unsuspected metastases. Manual of Surgery Volume First: General Surgery. Sixth Edition. In general, it may be said that periosteal tumours are less favourable than central ones, because they are more liable to give rise to metastases. Manual of Surgery Volume First: General Surgery. Sixth Edition. High amputation is unnecessary in the more benign sarcomas, and in the more malignant forms is usually unavailing to prevent a fatal issue either from local recurrence or from metastases in the lungs or elsewhere. Manual of Surgery Volume First: General Surgery. Sixth Edition. When metastasis takes place, as it occasionally does, the fungus is transmitted by the blood vessels, as in pyæmia. Manual of Surgery Volume First: General Surgery. Sixth Edition. Probably the most interesting of all these anomalies is the class in which, by a compensatory process, metastasis of the secretions is noticed. Anomalies and Curiosities of Medicine Secondary growths are met with chiefly in the lungs, metastasis taking place by way of the veins. Manual of Surgery Volume First: General Surgery. Sixth Edition. |
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