| 单词 | metabolite |
| 例句 | This might cause inflammation of the bowels, exacerbated by various dietary ingredients and their metabolites, with further possible health problems caused by bacterial endotoxins. Animal Doctor: How pet owners, and other animals, grieve a loss 2017-05-19T04:00:00Z She said incorporating the metabolites into studies of exposure may explain why levels of BPA in humans appeared to be very low, despite an increase of production of the chemical. BPA chemical levels in humans drastically underestimated, study finds 2019-12-05T05:00:00Z On average, CBD tends to appear for one to three days after consumption, but a study conducted by Mayo Clinic found that metabolites appeared in some patients up to 15 days after usage. What's actually the difference between CBD and THC? 2022-04-26T04:00:00Z Zeranol or its metabolites “is a risk linked to breast cancer development.” 6 nasty drugs your meat is on 2014-02-12T13:00:00Z It is entirely possible that the genetic parameters we used to predict the metabolites and microbial species associated with gut dysbiosis do not fully capture the complexity of the gut microbiota. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z At times of stress, he argues, we are physiologically in "survival mode", prompting the release of testosterone and its bioactive metabolite, DHT. Oxytocin: could the 'trust hormone' rebond our troubled world? 2011-08-20T23:08:00Z This is why the researchers are measuring hundreds of metabolites in participants’ blood after eating – such as ketones – as well as our gut microbe diversity. Eat more avocado! What I learned from the study that will change how we eat 2019-06-23T04:00:00Z We identified genetic variants associated with 10 fecal and blood metabolites. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z The metabolites included are small molecules produced by the gut microbiota that have previously been associated with gut dysbiosis and certain diseases. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z Many chemicals are analyzed without consideration of their metabolites, which may not be giving regulators a full understanding of the human health impacts, Hunt said. BPA chemical levels in humans drastically underestimated, study finds 2019-12-05T05:00:00Z As the body tries to process the alcohol metabolites in the bloodstream, it produces tiny molecules called cytokines. Everything you ever wanted to know about hangovers (but were too queasy to ask) 2016-12-12T05:00:00Z The plant-based meat, meanwhile, contained 31 metabolites that meat did not include. Plant-based meat not nutritionally the same as real meat: study 2021-07-07T04:00:00Z They also wanted to determine if, and by how much, a diet containing broccoli sprouts alleviates Crohn's symptoms, given the anti-inflammatory metabolites innately present in the sprouts. Early life exposure to broccoli sprouts protects against colitis in inflammatory bowel disease 2023-11-09T05:00:00Z To solve this puzzle, scientists began researching the so-called metabolome of bacteria -- everything that has to do with their metabolism, including metabolites such as sugars or fats. The metabolism of bacteria under the microscope: New method reveals host-microbe interactions 2023-11-08T05:00:00Z Several metabolites, including brominated alkaloids and furanoterpenoids, captured from seawater were present in three sponge species that the researchers had examined in detail. Device 'smells' seawater to discover, detect novel molecules 2023-11-08T05:00:00Z The researchers measured gene expression and the concentrations of small-molecular compounds, or metabolites, in the fetal intestine, brain and placenta. Maternal microbiota can affect fetal development 2023-11-01T04:00:00Z An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. A known environmental hazard can change the epigenetics of cells 2023-11-02T04:00:00Z In addition to assessing participants' self-reported food intake and several biomarkers, researchers also measured an array of dietary intake metabolites in blood. Is red meat intake linked to inflammation? 2023-10-26T04:00:00Z In a pioneering study, Liebeke's team developed a method with which they can identify individual bacteria and simultaneously determine which metabolites are present in the cells -- all without cultivating the bacteria in the laboratory. The metabolism of bacteria under the microscope: New method reveals host-microbe interactions 2023-11-08T05:00:00Z "It's exciting that this is the first demonstration that a simple, safe dietary intervention has an effect on the gut microbiome and metabolites in these patients," Reddy said. Dietary supplement modifies gut microbiome -- potential implications for bone marrow transplant patients 2023-10-20T04:00:00Z The researchers discovered that the expression of many important genes was associated with the concentration of metabolites likely to be modulated by the maternal microbiota. Maternal microbiota can affect fetal development 2023-11-01T04:00:00Z However, to protect themselves from sea slugs and other herbivores, the brown algae produce a secondary metabolite called phlorotannin that blocks this digestion, hindering the potential application of brown algae as feedstocks for biofuel. Predator-prey defense mechanisms unlock key to marine biofuel production 2023-10-10T04:00:00Z Plasma metabolites can help capture the effects of dietary intake as food is processed, digested and absorbed. Is red meat intake linked to inflammation? 2023-10-26T04:00:00Z The team analysed hundreds of metabolites on an area smaller than one square millimetre. The metabolism of bacteria under the microscope: New method reveals host-microbe interactions 2023-11-08T05:00:00Z Their distribution is peculiar: While specialized metabolites often occur in specific evolutionary related plant species, benzoxazinoids show the opposite behavior and occur sporadically in many distantly related plant families. Nature is inventive -- the same substance is produced differently by plants 2023-10-09T04:00:00Z These metabolites were absent in the foetuses of germ-free dams, or occurred at least at significantly lower concentrations. Maternal microbiota can affect fetal development 2023-11-01T04:00:00Z The findings are based on results of functional MRI brain scans, sophisticated statistical modeling techniques, and analyses of metabolites of the glutamate pathway in the digestive tract. Discrimination alters brain-gut 'crosstalk,' prompting poor food choices and increased health risks 2023-10-02T04:00:00Z "Our team sought to take a closer look by using metabolite data in the blood, which can provide a more direct link between diet and health." Is red meat intake linked to inflammation? 2023-10-26T04:00:00Z However, drawing the correct conclusions from the images of the metabolites is only possible if they know which bacteria produce or use them. The metabolism of bacteria under the microscope: New method reveals host-microbe interactions 2023-11-08T05:00:00Z To assess exposure to cigarette smoke, the team looked at levels of the metabolite cotinine, which can be detected in blood, urine, and saliva. Risk of premature birth from smoking while pregnant more than double previous estimates 2023-09-28T04:00:00Z "It would appear that such microbial products are likely to affect the development of the intestine and brain as well as the functioning of the placenta. Many of these metabolites are previously unknown," Niku notes. Maternal microbiota can affect fetal development 2023-11-01T04:00:00Z Through analysis of fecal samples, the researchers looked for changes in 12 glutamate metabolites -- substances resulting from the breakdown of glutamate. Discrimination alters brain-gut 'crosstalk,' prompting poor food choices and increased health risks 2023-10-02T04:00:00Z "From a biological perspective, this is the first time that a rare metabolite, I3AA, has been studied in detail, and is shown to promote inflammation," said A/Prof Tan. Gut inflammation caused by substance secreted by microbe 2023-09-29T04:00:00Z When the team forced electrons to primarily go through only one of these two routes, it led to the overproduction of a metabolite called succinate. Rewiring tumor mitochondria enhances the immune system's ability to recognize and fight cancer 2023-09-21T04:00:00Z A more objective measure is to look at levels of metabolites in the blood -- chemical by-products created when substances such as tobacco and caffeine are processed in the body. Risk of premature birth from smoking while pregnant more than double previous estimates 2023-09-28T04:00:00Z The group is now investigating the occurrence of microbial metabolites in other mammals: piglets and calves, as well as in the meconium and amniotic fluid samples of babies. Maternal microbiota can affect fetal development 2023-11-01T04:00:00Z This alters the profile of metabolites in the cells, boosting the levels of molecules that inhibit an epigenetic enzyme known as KDM5 and so changing the deposition of a key epigenetic "mark" on their chromosomes. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Reductive carboxylation acts directly on the generation of metabolites, small chemical elements that modify histones, to influence DNA packaging and to prevent accessibility to longevity genes. Strengthening artificial immune cells to fight cancer 2023-09-20T04:00:00Z In addition, the scientists did not even know where the metabolites of interest were accumulated in the different parts of plants. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z To assess caffeine intake, the researchers looked for the metabolite paraxanthine, which accounts for 80% of caffeine metabolism and is both less sensitive to recent intake and more stable throughout the day. Risk of premature birth from smoking while pregnant more than double previous estimates 2023-09-28T04:00:00Z Beckley Psytech, also UK-based, is looking at the intravenous administration of psilocybin's biologically active metabolite, psilocin, which would bring down the length of the trip to about an hour and a half. The firms hoping to take psychedelic drugs mainstream 2023-09-14T04:00:00Z Aspartame's potential risks don't come from the chemical itself but instead metabolites that are formed when the body breaks it down. Does aspartame cause cancer? "Possibly," a new WHO report concludes 2023-07-14T04:00:00Z Secondary metabolites of fungi are used as medicines, such as antibiotics and anticoagulants. Fundamentals of Biology 2015-01-01T00:00:00Z The authors established the first stable transformation system to modify foxglove plants for the study of specialised metabolites. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z Secondary metabolites of fungi are used in medicine as antibiotics and anticoagulants. Concepts of Biology 2013-04-25T00:00:00Z However, psilocybin and other naturally-occurring mushroom metabolites were found in the analysis. Church claims to have made a super-drug that combines shrooms and toad venom 2023-04-20T04:00:00Z These metabolites include phenylalanine, aspartic acid and methanol. Does aspartame cause cancer? "Possibly," a new WHO report concludes 2023-07-14T04:00:00Z Ascomycetes not only infest and destroy crops directly; they also produce poisonous secondary metabolites that make crops unfit for consumption. Fundamentals of Biology 2015-01-01T00:00:00Z Plants produce an impressive array of metabolites, including many medically valuable steroids. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z Instead, they synthesize a large range of poisonous secondary metabolites: complex organic molecules such as alkaloids, whose noxious smells and unpleasant taste deter animals. Concepts of Biology 2013-04-25T00:00:00Z Hair follicles are connected to the bloodstream, which means they can absorb the metabolites of drugs like psychedelics, opioids, cannabis and more. Bronze Age Europeans were getting high on all kinds of drugs, hair analysis study finds 2023-04-12T04:00:00Z The reason is that eating cannabis produces metabolites that are technically a different drug from THC entirely. We asked experts why cannabis edibles produce such a different high than smoking 2023-03-04T05:00:00Z In contrast, as plants co-evolved with animals, the development of sweet and nutritious metabolites lured animals into providing valuable assistance in dispersing pollen grains, fruit, or seeds. Fundamentals of Biology 2015-01-01T00:00:00Z The same three urinary metabolites — one that is a “strong indicator of reduced photo damage,” SciTechDaily wrote — were depressed in each person with UV resistance. Eating grapes might protect you against sunburn, skin cancer 2023-01-30T05:00:00Z Additionally, as plants coevolved with animals, sweet and nutritious metabolites were developed to lure animals into providing valuable assistance in dispersing pollen grains, fruit, or seeds. Concepts of Biology 2013-04-25T00:00:00Z The team tested the molecular composition of the fluid and identified 185 proteins that were specific to it, as well as more than 100 metabolites such as amino acids, sugars and vitamins. Ants Can Produce Milk for Their Young (and Old) 2022-12-02T05:00:00Z The reason is that eating cannabis produces metabolites that are technically a different drug from THC entirely. We asked experts why cannabis edibles produce such a different high than smoking 2023-03-04T05:00:00Z Many modern synthetic therapeutic drugs are derived or synthesized de novo from plant secondary metabolites. Fundamentals of Biology 2015-01-01T00:00:00Z The law still allows employers to require drug screening as a condition of employment, as long as the tests “do not screen for nonpsychoactive cannabis metabolites.” California workers won't have to worry about being fired, or not hired, for off-the-clock marijuana use 2022-09-19T04:00:00Z Many secondary metabolites of fungi are of great commercial importance. Concepts of Biology 2013-04-25T00:00:00Z A small study published in Environmental Research in 2019 revealed that people who switched from a conventional diet to an organic one had lower levels of pesticide metabolites in their urine. Four common questions to ask about organic food 2022-08-22T04:00:00Z Shoddy chemistry is part of the equation, but we also know very little about what metabolites form from these newish semi-synthetic THC analogs. We asked experts why cannabis edibles produce such a different high than smoking 2023-03-04T05:00:00Z The goal of metabolome research is to identify, quantify, and catalogue all of the metabolites that are found in the tissues and fluids of living organisms. Biology for AP Courses 2022-06-09T00:00:00Z After using cannabis, the chemical compound that can cause psychoactive effects, tetrahydrocannabinol, or THC, becomes a non-psychoactive cannabis metabolite, which can remain in the system for weeks. California workers won't have to worry about being fired, or not hired, for off-the-clock marijuana use 2022-09-19T04:00:00Z That substance is a metabolite of meclofenoxate, which is a prohibited stimulant that hadn’t been much on the antidoping radar for years. Doping sleuths keep sunscreen from burning track stars 2022-07-15T04:00:00Z An overdose of aspirin causes acidosis due to the acidity of this metabolite. Anatomy and Physiology 2013-06-19T00:00:00Z This vacuole pushes the cell’s essential proteins, sugars and metabolites against its membrane, facilitating easier diffusion. Scientists baffled by discovery of bacteria that ought to be too big to function 2022-06-23T04:00:00Z Many metabolites are toxic, and can even be lethal to animals that ingest them. Biology for AP Courses 2022-06-09T00:00:00Z EPA spokesperson Cathy Milbourn says the agency “has a robust process for identifying and assessing the environmental risks of pesticide degradation products or metabolites.” Pesticides Are Spreading Toxic ‘Forever Chemicals,’ Scientists Warn 2022-06-15T04:00:00Z He also had the strong painkiller ketamine and its metabolite norketamine in his system. Report: Steelers QB Haskins was drunk when fatally struck 2022-05-23T04:00:00Z Subsequent lab testing showed a metabolite that is only found in the ointment in the horse’s urine. Kentucky regulators recorded calls without consent with Baffert after Medina Spirit test 2022-04-03T04:00:00Z Without it, the levels of that so-called metabolite in the bats’ brain skyrocket. Lost Genes Explain Vampire Bats’ Diet of Blood 2022-03-25T04:00:00Z Plants also have chemical defenses, including toxic secondary metabolites and hormones, which elicit additional defense mechanisms. Biology for AP Courses 2022-06-09T00:00:00Z The presence of alcohol metabolites in a pregnant person's blood — or in a baby's first fecal matter — could potentially identify an additional subset. In-utero alcohol exposure: new tools for a difficult diagnosis 2022-02-17T05:00:00Z “In contrast, we observed that metabolites related to unhealthy dietary patterns, including artificial sweeteners and alcohol, showed a deleterious association with cognitive decline.” Perspective | Anti-aging ‘superfoods’ aren’t enough. Try one of these healthy overall eating plans. 2021-12-17T05:00:00Z Puthucheary and his colleagues are conducting a small study to test whether ketones — an alternative fuel source derived from the body's breakdown of fat — or an amino acid metabolite called hydroxy methylbutyrate might work better. Recovery from an ICU stay is tough. Could more protein help? 2021-08-29T04:00:00Z Past research has determined that higher levels of the metabolite was responsible for increasing memory, learning and sociability in rodents. Lost Genes Explain Vampire Bats’ Diet of Blood 2022-03-25T04:00:00Z The same vesicles are able to interact and exchange metabolites with the intracellular environment. Biology for AP Courses 2022-06-09T00:00:00Z But because these metabolites break down quickly, the window for testing is limited. In-utero alcohol exposure: new tools for a difficult diagnosis 2022-02-17T05:00:00Z It’s one thing to say the metabolite didn’t process through the system fast enough and another to say the horse was never administered the drug. What's next after Kentucky Derby winner Medina Spirit's positive drug test? 2021-05-10T04:00:00Z These patients had extraordinarily high levels of brain dopamine metabolites. Doctors said the boy was suffering from teenage psychosis. What he really had was a rare genetic condition. 2021-04-30T04:00:00Z Another one of the metabolites identified in the new study was phenylacetylglutamine. A Changing Gut Microbiome May Predict How Well You Age 2021-03-18T04:00:00Z Plants need both photosynthesis and respiration for their ability to function in both the light and dark, and to be able to interconvert essential metabolites. Biology for AP Courses 2022-06-09T00:00:00Z They measured 67 drugs and drug metabolites by passing the mixtures through a high-performance mass spectrometer, which detected different molecules based on their charge and weight. Tooth tartar could uncover the drug habits of ancient people 2021-01-07T05:00:00Z The researchers focused on metabolites, which are molecules related to metabolic processes. The ‘Omics’ of Exercise 2020-11-25T05:00:00Z He conducted spinal taps in some of his patients to get samples of cerebrospinal fluid and looked for dopamine metabolites, a byproduct of dopamine. Doctors said the boy was suffering from teenage psychosis. What he really had was a rare genetic condition. 2021-04-30T04:00:00Z The punishment was handed down by France Galop, four months after Murphy returned a positive test for metabolites of the drug in a test undertaken at Chantilly. Champion jockey of British horse racing handed 3-month ban 2020-11-27T05:00:00Z Metabolomics involves the study of small molecule metabolites found in an organism. Biology for AP Courses 2022-06-09T00:00:00Z An AI-based algorithm reacts to specific metabolites in the urine, providing the user with a fast diagnosis. Home-testing kit for breast cancer wins Dyson prize 2020-11-19T05:00:00Z Again, these metabolites changed in the same ways as before. The ‘Omics’ of Exercise 2020-11-25T05:00:00Z Oisin Murphy returned a positive test for metabolites of the drug in a test undertaken in France on July 19, a statement from the Professional Jockeys Association read on Thursday. Champion jockey of British racing tests positive for cocaine 2020-10-01T04:00:00Z While developing in utero, mouse embryos receive metabolites from maternal gut microorganisms. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z The metabolome is the complete set of metabolites that are related to the genetic makeup of an organism. Biology for AP Courses 2022-06-09T00:00:00Z Asking whether a particular metabolite is associated with a disease is not the same as searching a set of metabolites to see whether any are associated with it. How scientists can stop fooling themselves over statistics 2020-08-02T04:00:00Z Last and perhaps most intriguing, the researchers created what they called molecular “signatures” of the levels of a few, representative metabolites that changed with exercise. The ‘Omics’ of Exercise 2020-11-25T05:00:00Z As yet, none of them are detectable using the long-term metabolite tests. The 'real' threat to Russia’s former doping mastermind 2020-07-30T04:00:00Z Vuong et al.1 report that these metabolites aid normal wiring by neuronal projections called axons that connect brain regions called the thalamus and the cortex. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z Their levels increase when a plant is wounded by a predator, resulting in an increase in toxic secondary metabolites. Biology for AP Courses 2022-06-09T00:00:00Z The researchers measured urine concentrations of phthalate metabolites in men and women at the start of the study, and then again in women just before ovulation and in men at the start of fertility treatment. Exposure to Plastic Chemicals Before Conception Tied to Premature Births 2020-04-09T04:00:00Z When an individual takes a drug, the body metabolizes it and excretes metabolites. Want to Know if a New Drug Crisis Is Emerging? 2020-03-23T04:00:00Z It’s a potentially less toxic metabolite of the malaria drug that’s used to treat certain autoimmune diseases like lupus and rheumatoid arthritis. Coronavirus drugs: Where we are and what we know 2020-03-21T04:00:00Z One possible means of transmission between these distant sites is by metabolite molecules that are produced by gut microbes and absorbed into the bloodstream5,6. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z Secondary metabolites are compounds that are not directly derived from photosynthesis and are not necessary for respiration or plant growth and development. Biology for AP Courses 2022-06-09T00:00:00Z The authors speculated that metabolites — molecules arising from metabolic processes — were responsible for this effect. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z Just as urine tests detect these metabolites for individuals, wastewater testing can reveal what drugs are being used in a city or region in the aggregate. Want to Know if a New Drug Crisis Is Emerging? 2020-03-23T04:00:00Z Schoeman claimed in a statement that his positive test for metabolites of the substance GW501516 in May 2019 was likely down to contamination in “carefully selected” supplements he was taking at the time. Ex-Olympic swim champ blames contamination for failed test 2020-02-08T05:00:00Z During pregnancy, these metabolites, along with other nutrients from the maternal circulation, are transported by way of the placenta to the fetus. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z Over the past decade, it’s become clear that gut microbes can produce DNA-damaging toxins and carcinogenic metabolites, induce cancer-promoting inflammation, make tumours more resistant to chemotherapy drugs, and suppress the body’s anticancer immune responses. Fighting cancer with microbes 2020-01-28T05:00:00Z By profiling different cell types undergoing apoptosis in response to different triggers, Medina et al. identified metabolites that were consistently released from all dying cells, whereas other metabolites in the cells were not released. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z Drug metabolite analysis could be added to these protocols at minimal expense. Want to Know if a New Drug Crisis Is Emerging? 2020-03-23T04:00:00Z Among the pathways, it found an association between higher quality of life and the presence of bacteria that produce a metabolite of the neurotransmitter dopamine. Highlights from studies on the gut microbiome 2020-01-28T05:00:00Z Using an approach called discovery metabolomics, the authors found that the maternal microbiota affected the levels of many metabolites in maternal blood and fetal brain tissue. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z And gut bacteria produce a range of enzymes and metabolites that might chemically alter drugs as varied as psychotropics and cancer treatments, rendering them less useful or leading to more side effects. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z The authors examined six metabolites released from all apoptotic cells and found that none, individually, had a significant effect on the gene-expression profile of macrophages. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z A spike in detected metabolites could have given everyone early warning. Want to Know if a New Drug Crisis Is Emerging? 2020-03-23T04:00:00Z It is unclear why dead bacteria were more effective, but the results suggest that the bacteria’s metabolites or cell-wall fragments might be therapeutically active. Highlights from studies on the gut microbiome 2020-01-28T05:00:00Z At present, the details of how these microbiota-derived metabolites affect developing neurons are unclear. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z When the team gave the two missing metabolites to mice with autism-like symptoms, Sharon says, “they improved core deficits in social interaction and repetitive behaviour”. Could the gut microbiome be linked to autism? 2020-01-28T05:00:00Z The authors report that administering a mixture of these three metabolites had remarkable anti-inflammatory effects in vivo — inhibiting disease in a mouse model of arthritis and limiting the rejection of lung transplants in mice. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z In the case of multiple sclerosis, “I don’t think the bacteria move, but their metabolites do,” says Patrizia Casaccia, a neuroscientist at the City University of New York. Could a bacteria-stuffed pill cure autoimmune diseases? 2020-01-28T05:00:00Z When the authors looked for correlations between metabolites and microbiome structure, they found nine metabolites were affected by changes to the microbiome. Highlights from studies on the gut microbiome 2020-01-28T05:00:00Z Understanding the composition of the maternal microbiota and the metabolites that reach the fetus presents a clear potential pathway for the development of clinical interventions. Maternal microbes support fetal brain wiring 2020-09-22T04:00:00Z But these data are complex and multi-dimensional, and there might be a whole web of interactions, involving multiple species and pathways, which ultimately produce a set of metabolites. Technologies to watch in 2020 2020-01-20T05:00:00Z Medina and colleagues’ work opens rich possibilities for future investigations into how apoptosis triggers metabolic changes, and how the regulated release of metabolites influences tissues. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z She notes that the metabolites might signal through the vagus nerve, which transmits messages from the gut to the brain. Could a bacteria-stuffed pill cure autoimmune diseases? 2020-01-28T05:00:00Z Martin tested positive for the presence of androsterone and etiocholanone, which are metabolites of testosterone, following an in-competition test after his match against Josh Taylor in Glasgow on Nov. 3, 2018. Boxing: American Martin gets four-year ban for anti-doping violation 2019-11-20T05:00:00Z Among the multiple possibilities, several researchers are currently investigating microbial metabolites. Targeting Gut Microbes May Help Stroke Recovery 2019-11-19T05:00:00Z Rather than apply statistical methods to find microbe–metabolite associations, we build mechanistic models of how we think a specific microbial composition affects the metabolome, and use these as part of the analyses themselves. Technologies to watch in 2020 2020-01-20T05:00:00Z One way in which these metabolites signal is through the chemical modification of proteins such as histones. Histone lactylation links metabolism and gene regulation 2019-10-22T04:00:00Z The authors hypothesize that this role in behavioural adaptation involves metabolite molecules that are produced by the microbiota and circulate in the blood. Gut microbes regulate neurons to help mice forget their fear 2019-10-22T04:00:00Z “The data seem to suggest that metabolites of that drug given at those doses might have been poorly tolerated in that very frail population.” Pharma’s roller-coaster relationship with RNA therapies 2019-10-15T04:00:00Z Metabolomics — as the study of metabolites is known — is easier said than done, however. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z But whether that fitness is reflected in the patterns of metabolites in their blood and, if so, what those patterns might tell us about how physical activity molds metabolisms, remained largely unknown. Aerobic Fitness May Trump Strength for Metabolic Health 2019-09-04T04:00:00Z Lactate is an abundant metabolite produced during glycolysis — a central metabolic process in which glucose consumed by cells is broken down to generate energy. Histone lactylation links metabolism and gene regulation 2019-10-22T04:00:00Z They suggest that the metabolites modulate the ability of the brain’s immune cells, microglia, to engulf and degrade structures called dendritic spines that form synaptic connections between neurons. Gut microbes regulate neurons to help mice forget their fear 2019-10-22T04:00:00Z The autopsy report noted the absence of norfentanyl, a metabolite of fentanyl, which Wecht said “means that fentanyl was ingested not long before death occurred.” Tyler Skaggs' autopsy: Fentanyl, oxycodone and alcohol led to death by choking on vomit 2019-08-30T04:00:00Z Siuzdak’s lab created METLIN, a database of tandem mass spectra — which reveal structural details of molecular fragments — on more than half a million metabolites and other molecules. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z But there were few differences over all in the metabolite profiles of the strongest men and those who were relatively weak. Aerobic Fitness May Trump Strength for Metabolic Health 2019-09-04T04:00:00Z Zhang and colleagues’ discovery that lactate is used for histone modification is intriguing both because of the metabolite’s abundance and because its production, uptake and use are all subject to dynamic regulation5. Histone lactylation links metabolism and gene regulation 2019-10-22T04:00:00Z The authors found four metabolites that were significantly less abundant in microbiota-deficient mice than in controls. Gut microbes regulate neurons to help mice forget their fear 2019-10-22T04:00:00Z The best-known examples of this are cases in which metabolites provide substrates for enzymes that regulate gene expression by modifying chemical groups attached to DNA or to the histone proteins that bind to DNA. Metabolic signal curbs cancer-cell migration 2019-06-25T04:00:00Z In the first study3, conducted when she was a postdoc at Yale University in New Haven, Connecticut, Zimmermann-Kogadeeva and her colleagues looked at the antiviral drug brivudine, from which gut microbes produce a toxic metabolite. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z The research involved only healthy, young, male Finns, though, and does not show that endurance changed people’s metabolomes, but only that their fitness and metabolites were linked. Aerobic Fitness May Trump Strength for Metabolic Health 2019-09-04T04:00:00Z They wanted to do that by comparing metabolite levels in the sewage to sales figures for the legal market. Gee whiz: Testing of sewage confirms rise in marijuana use 2019-06-24T04:00:00Z They therefore posit that the microbiota affects neurons and microglia in the brain through metabolites that are released into the circulation. Gut microbes regulate neurons to help mice forget their fear 2019-10-22T04:00:00Z The idea that metabolites—the molecules produced by bacterial digestion—can influence brain activity “is plausible, it makes sense, and it will help push the field forward.” Gut bacteria may contribute to autism symptoms, mouse study finds 2019-05-30T04:00:00Z “MAGI recognizes that metabolomic and genomic data are orthogonal, and puts those pieces of information together to help identify metabolites and identify genes.” Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z Studies based on characterizing genetic material, proteins or metabolites using high-throughput analyses will remain the norm for the foreseeable future. Priorities for the next 10 years of human microbiome research 2019-05-28T04:00:00Z They had been measuring concentrations of stress-related hormone metabolites in the feces of right whales in the Bay of Fundy. Is Noise Pollution the Next Big Public-Health Crisis? 2019-05-06T04:00:00Z Chu and colleagues’ work raises the possibility of targeting the gut microbiota and its metabolites as a strategy for helping such individuals. Gut microbes regulate neurons to help mice forget their fear 2019-10-22T04:00:00Z When the researchers looked at the contents of the mouse guts, they found differences between the two groups in the levels of 27 metabolites. Gut bacteria may contribute to autism symptoms, mouse study finds 2019-05-30T04:00:00Z In a paper under review, Majumder describes a strategy to mine the scientific literature for clues that predict metabolite functions in specific biological contexts. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z Does it involve the exchange of metabolites such as hydrogen molecules, small organic molecules or sulfur-containing molecules between the partner species? Elusive microbe that consumes ethane found under the sea 2019-03-26T04:00:00Z In mid-September, 2001, the metabolite concentrations fell; when they were measured again the following season, they had gone back up. Is Noise Pollution the Next Big Public-Health Crisis? 2019-05-06T04:00:00Z Working in mice and human cell lines, Area Gómez says her group has identified unique patterns of metabolites produced as a consequence of the excessive contacts wrought by C99. How secret conversations inside cells are transforming biology 2019-03-10T05:00:00Z The two metabolites highlighted in this study might turn out to be irrelevant to autism in people. Gut bacteria may contribute to autism symptoms, mouse study finds 2019-05-30T04:00:00Z These ‘metabolites’ serve not only as markers for charting health and disease, but also as engines of physiological change1. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z Chen et al. think that, for ethane oxidation, the transfer of a sulfur-containing metabolite is the process most likely to underlie the interaction between these two types of microorganism. Elusive microbe that consumes ethane found under the sea 2019-03-26T04:00:00Z But when two more tests last month revealed tiny amounts of the metabolite, Jones finally didn’t cry. Jon Jones clear-eyed, clear-headed facing Smith at UFC 235 2019-03-01T05:00:00Z She is exploring whether a blood test for these metabolites could identify subcellular signs of Alzheimer’s disease in otherwise healthy individuals. How secret conversations inside cells are transforming biology 2019-03-10T05:00:00Z Still, the research justifies a hunt for other metabolites deficient in the gut or brain of people with the disorder, he says. Gut bacteria may contribute to autism symptoms, mouse study finds 2019-05-30T04:00:00Z Another question concerns the impact of microbial metabolites on the host. Microbial chemistry gains fresh focus 2019-09-23T04:00:00Z Urine samples taken over the course of the study were tested for pesticides and the chemicals pesticides break down into, called metabolites. What the pesticides in our urine tell us about organic food 2019-02-15T05:00:00Z To do that, he plans to alter levels of plant metabolites known as catechins. Genomic focus brings tea research to the boil 2019-02-05T05:00:00Z They found preliminary evidence of selection for several enzymes involved in the generation of secondary metabolites, including caffeine. The growth of tea 2019-02-05T05:00:00Z Instead, the authors suggest that metabolite molecules secreted by these bacteria might circulate in the host’s body and boost T cells elsewhere. A gut punch fights cancer and infection 2019-01-22T05:00:00Z “Data shows a great presence of illicit drugs and their metabolites in surface waters worldwide,” biologist Anna Capaldo, lead author of the 2018 study, told National Geographic at the time. Cocaine in London river is making eels 'hyperactive,' researchers say 2019-01-21T05:00:00Z Two of the seven tests – one in August and another in September – identified the presence of the M3 metabolite. How Jon Jones sparked UFC 232's 'atypical' move from Vegas to LA 2018-12-29T05:00:00Z Bacteria from the genus Streptomyces are particularly prolific metabolite producers and the source of numerous antibiotics. Bacterial defence molecules target viral DNA 2018-12-04T05:00:00Z Some researchers, including Rogers, are using them to measure metabolites such as lactic acid — a sign of muscle fatigue — or glucose in sweat. Moving skin beyond the biological 2018-11-20T05:00:00Z The complexity of living cells is staggering — their cytoplasm contains tens of thousands of distinct macromolecules and metabolites that must be coordinated to interact in time and space. Cell parts to complex processes, from the bottom up 2018-11-05T05:00:00Z If this gene, called HPD, is disabled, then no toxic metabolites of tyrosine ever get to where FAH is unable to handle them. CRISPR Cures Inherited Disorder in Mice 2018-10-09T04:00:00Z Contrast “we aim to quantify a large number of metabolites” with “we aim to quantify 1,000 metabolites”. Beating the odds to secure a permanent contract 2018-10-02T04:00:00Z How important is this mechanism, and how are these metabolites made? Bacterial defence molecules target viral DNA 2018-12-04T05:00:00Z He said the vast majority of women even with elevated levels of the DDT metabolite did not have offspring with autism. DDT banned for decades may still be affecting autism risk 2018-09-20T04:00:00Z He reclaimed the light heavyweight title from Daniel Cormier last summer, but the victory was taken away when he tested positive for a steroid metabolite. UFC’s Jones suspended 15 months by USADA; can return in fall 2018-09-19T04:00:00Z One project looks at how gene expression and the production of metabolites change as the disease progresses through two phases of assault. Searching for Chocolate's Roots, and Enemies, in Colombia's Wilderness 2018-09-15T04:00:00Z Above the resulting publication list are categories such as ‘metabolites’ or ‘diseases’. How AI technology can tame the scientific literature 2018-09-09T04:00:00Z Blair tested positive for a metabolite of the steroid metandienone after an out-of-competition test while in France for the European Team Championships in June 2017, after which she was provisionally suspended. Athletics: British javelin thrower Blair hit with four-year ban 2018-08-03T04:00:00Z Dozens of cities across China are applying an unusual forensic technique to monitor illegal drug use: chemically analysing sewage for traces of drugs, or their telltale metabolites, excreted in urine. China expands surveillance of sewage to police illegal drug use 2018-07-15T04:00:00Z There, researchers measured levels of hormones called melatonin and cortisol, which rise and fall according to the body’s master clock, along with levels of metabolites linked to digestion. Nightshifts disrupt rhythm between brain and gut, study shows 2018-07-09T04:00:00Z Does it include only gene sequences, for instance, or also data on an organism’s gene transcription and its metabolites? Plan to amend biopiracy rules would ‘smother research,’ biologists warn 2018-07-03T04:00:00Z “Data show a great presence of illicit drugs and their metabolites in surface waters worldwide,” says Anna Capaldo, a research biologist at the University of Naples Federico II and the lead author of the study. Some Rivers Are So Drug-Polluted, Their Eels Get High on Cocaine 2018-06-20T04:00:00Z But that increases cost, which starts at about $10,000 a year per city and varies based on factors such as frequency of sampling and the list of metabolites measured. Sewage Is Helping Cities Flush Out the Opioid Crisis 2018-05-25T04:00:00Z The sensor also needs to be able to pick up on the metabolites rapidly so it can send out its signal before it gets shuttled along to another part of the GI tract. Gut Sensor Could Monitor Health--and Beam Results to a Smartphone 2018-05-24T04:00:00Z The night shifts also disrupted the rhythms of two metabolites linked to chronic kidney disease. Nightshifts disrupt rhythm between brain and gut, study shows 2018-07-09T04:00:00Z The metabolites, Mazmanian adds, may send a signal through the vagus nerve or bypass it completely through another pathway such as the bloodstream. Does Parkinson's Begin in the Gut? 2018-05-08T04:00:00Z After testing positive for a jazz salt metabolite, which evidence suggests came from a mug of cocoa tea, he may be punished according to Wada’s strict liability rule. World Cup Fiver | The chances of a spectacular implosion have definitely lengthened 2018-05-03T04:00:00Z The babies seeded with B. infantis also had fewer pathogenic bacteria and more beneficial metabolites in their gut than did breastfed babies who did not receive the probiotic. How baby’s first microbes could be crucial to future health 2018-03-06T05:00:00Z The GI tract houses a myriad of metabolites that scientists hope could shed light on what happens in the dark of the digestive system. Gut Sensor Could Monitor Health--and Beam Results to a Smartphone 2018-05-24T04:00:00Z As part of ongoing health monitoring they tested the female squirrels’ droppings for steroids called fecal metabolites—a technique Wells first used on cheetahs—which revealed when the animals were fertile. Squirrel Sex Is Complicated 2018-01-19T05:00:00Z This activation was, in turn, crucial for the generation of metabolites required for viral replication. Viruses hijack a long non-coding RNA They then showed that when the mice broke down disulfiram, its main metabolite, ditiocarb, forms a complex with copper that blocks the machinery that cells use to dispose of misfolded and unneeded proteins. An old drug for alcoholism finds new life as cancer treatment 2017-12-06T05:00:00Z To see if the metabolites changed antibiotic effectiveness, Collins and his colleagues added these isolated chemicals to E. coli grown in lab plates. A New Antibiotic Weakness--Drugs Themselves Help Bacteria Survive 2017-12-04T05:00:00Z The researchers envision tweaking the bacteria so they can recognize a range of metabolites. Gut Sensor Could Monitor Health--and Beam Results to a Smartphone 2018-05-24T04:00:00Z Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites 2017-11-21T05:00:00Z This enzyme produces metabolites that enable higher rates of viral replication. Viruses hijack a long non-coding RNA For unclear reasons, the copper metabolite is 10 times more abundant in tumor tissue compared with other tissues, the group found. An old drug for alcoholism finds new life as cancer treatment 2017-12-06T05:00:00Z It is unlikely the host cells are producing these metabolites as part of a directed reaction, Yang says. A New Antibiotic Weakness--Drugs Themselves Help Bacteria Survive 2017-12-04T05:00:00Z This table contains a curated list of 25 common metabolites utilized by the enzymes screened. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis 2017-11-21T05:00:00Z Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Salt-responsive gut commensal modulates TH17 axis and disease 2017-11-14T05:00:00Z If microbial load varies substantially between samples, relative profiling will hamper attempts to link microbiome features to quantitative data such as physiological parameters or metabolite concentrations5,6. Quantitative microbiome profiling links gut community variation to microbial load 2017-11-14T05:00:00Z But it is also a sponge-like carrier protein, long understood to bind and inactivate many of the proteins and metabolites that travel in plasma. Neuroscience: The power of plasma : Nature : Nature Research 2017-09-26T04:00:00Z The aim of the research was to evaluate the influence of the elephants' body condition on glucocorticoid metabolites. Freeze-dried dung gives clue to Asian elephant stress - BBC News 2017-08-16T04:00:00Z Angels minor league right-hander Aaron Cox received a 50-game suspension Friday for testing positive for methylphenidate and its metabolite. Angels call-up Troy Scribner's parents learn it pays to have a passport 2017-07-28T04:00:00Z They tuned the spectrometer to search for hundreds of different metabolites. Naked mole-rats are now even weirder: Without oxygen, they live like plants 2017-04-20T04:00:00Z He uses mass spectrometry to create high-resolution maps of the chemical metabolites found in each sample. Do Seas Make Us Sick? Surfers May Have the Answer 2017-04-03T04:00:00Z A range of cancers could have new treatment options thanks to the discovery that a metabolite made by many tumours increases their vulnerability to a class of drug. Cancer biology: Rogue metabolite halts DNA repair : Nature : Nature Research 2017-02-21T05:00:00Z These hormones are released into the circulatory system which eventually breaks them down into metabolites that are excreted through urine or faeces. Freeze-dried dung gives clue to Asian elephant stress - BBC News 2017-08-16T04:00:00Z Cancer Research UK awarded another team up to £16 million to make a similar tumour map that will focus on metabolites and proteins. The race to map the human body — one cell at a time 2017-02-19T05:00:00Z To understand whether trees with low and high susceptibility vary in their metabolite profiles as well as their transcriptomes, we undertook untargeted metabolite profiling on a subset of the Danish Test Panel. Genome sequence and genetic diversity of European ash trees : Nature : Nature Research 2016-12-25T05:00:00Z A study recently made headlines that connected people who ate fast food with dose-dependent higher levels of phthalate metabolites than infrequent eaters. 8 Ways Eating Can Improve Your Mental Health 2016-11-17T05:00:00Z Cellular communication occurs at numerous levels, from cells to tissues, across an organism and is accomplished by a myriad of molecules, including secreted proteins, lipids and metabolites, which must be tightly controlled. Ageing, neurodegeneration and brain rejuvenation : Nature : Nature Research 2016-11-08T05:00:00Z Dr Sukumar and his team claim that their study is the "first to examine the relationship between body condition, seasonality and stress in wild Asian elephants using large-scale faecal sample collection for assaying glucocorticoid metabolites". Freeze-dried dung gives clue to Asian elephant stress - BBC News 2017-08-16T04:00:00Z They imaged this group using three different tracers for dopamine and related metabolites. Diagnosis: Warning signs : Nature : Nature Research 2016-10-25T04:00:00Z The results are not foolproof — analysis of cannabis metabolites is chemically tricky, for example, and cannot distinguish between all sources — but the study did report some successes. Using waste water to flush out drug dealers 2016-09-13T04:00:00Z They found that 80 percent of the metabolites were lower in those with CFS. Chronic fatigue syndrome may be a human version of ‘hibernation’ 2016-09-06T04:00:00Z An MLB press release described the substance as a metabolite of nandrolone. Angels are hoping for recovery after 2-1 loss to Rangers 2016-09-09T04:00:00Z Brewing yeasts differ in their production of these metabolites and in other traits such as their tolerance to alcohol. Ale genomics: how humans tamed beer yeast 2016-09-07T04:00:00Z It may be a coincidence, but six of the diagnostic metabolites whose levels are low in CFS are also low in dauer. Blood simple? 2016-09-01T04:00:00Z Drugs broken down in the body leave telltale traces of metabolites, some of which can be found, quantified and back-calculated to work out how much of the original substance was present. Using waste water to flush out drug dealers 2016-09-13T04:00:00Z Naviaux looked at 612 different metabolites, which are intermediate substances such as glucose produced by cells as they break down larger molecules and produce energy. Chronic fatigue syndrome may be a human version of ‘hibernation’ 2016-09-06T04:00:00Z The change could muddy toxicology studies that rely on urine metabolites to measure how a drug gets broken down in the body. Mouse microbes may make scientific studies harder to replicate 2016-08-16T04:00:00Z But all told, these sorts of secreted compounds, called secondary metabolites, are rare within the human microbiome—and it’s even more uncommon to learn how and why bacteria use them, as researchers did with lugdunin. Antibiotic Found in Noses—Here’s What You Need to Know 2016-07-27T04:00:00Z They then trawled through those samples looking at the levels of 612 specific chemicals, known as metabolites, which are produced during the day-to-day operations of living cells. Blood simple? 2016-09-01T04:00:00Z For pain, expression of inflammatory mediators in the blood and the presence of metabolites in saliva could be biological guides to a person’s distress. Fifty shades of pain 2016-07-12T04:00:00Z Ultimately, these databases and infrastructures for analysis will allow the estimation of metabolite flux from the genomes to enable prediction of the overall function of communities of microbes42. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Expression of these enzymes is increased by metabolites that are produced by B. thetaiotaomicron38. Interactions between the microbiota and pathogenic bacteria in the gut : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The influence of the microbiome on the migration and gene expression of tissue-resident myeloid cells is achieved mainly through the modulation of local metabolites and mediators of tissue identity. The microbiome and innate immunity : Nature : Nature Publishing Group 2016-07-05T04:00:00Z These metabolite profiles, they found, differed clearly and systematically between the patients and the controls. Blood simple? 2016-09-01T04:00:00Z The gut microbiota interacts with dietary components and metabolites to form bioactive metabolites that signal to the host through distinct mechanisms. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z These tryptophan metabolites are thought to affect neuronal signalling in the gut and brain51. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z However, two underlying themes converge: microbiota-induced changes in the metabolite landscape of the gut and inflammation. Interactions between the microbiota and pathogenic bacteria in the gut : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The influence of the microbiome on the migration and gene expression of tissue-resident myeloid cells is achieved mainly through the modulation of local metabolites and mediators of tissue identity. The microbiome and innate immunity : Nature : Nature Publishing Group 2016-07-05T04:00:00Z This allows researchers to start predicting, computationally, the structures and functions of thousands of metabolites. The man who can map the chemicals all over your body 2016-06-06T04:00:00Z The gut microbiota interacts with dietary components and metabolites to form bioactive metabolites that signal to the host through distinct mechanisms. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Some specialized metabolites from the human microbiota are known to cause disease. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Also, scientists can develop more sensitive tests for metabolites - residue - of known drugs that are found in urine. How it works: a look at the retests of Olympic drug samples 2016-05-22T04:00:00Z Intestinal epithelial cells use the recognition of microbial-cell components and metabolites to adjust their antimicrobial programme and metabolic homeostasis. The microbiome and innate immunity : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Also, scientists can develop more sensitive tests for metabolites — residue — of known drugs that are found in urine. How it works: a look at the retests of Olympic drug samples 2016-05-22T04:00:00Z The microbiota produces a vast number of metabolites and much work remains to be done to investigate fully their functions in physiology and pathophysiology. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The final group is the exposome, which describes the chemistry and metabolites that are encountered through exposure to personal-care products, medical intervention, food or the environment. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z But they also made an important discovery about one of ketamine’s byproducts—one metabolite in particular—which remain in the body for days after the drug is taken. ‘Club Drug’ Ketamine Provides Hope Against Depression 2016-05-11T04:00:00Z Intestinal epithelial cells use the recognition of microbial-cell components and metabolites to adjust their antimicrobial programme and metabolic homeostasis. The microbiome and innate immunity : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The mice also did not tend to press a lever to receive the metabolite when given the option to self-administer it. How club drug ketamine fights depression 2016-05-03T04:00:00Z The relevance of some of these metabolites in humans is yet to be established. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The second group comprises specialized metabolites, which includes virulence factors, secondary metabolites and natural products. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z This metabolite appears to trigger the antidepressant effects of ketamine, but without the side effects and addictive potential. ‘Club Drug’ Ketamine Provides Hope Against Depression 2016-05-11T04:00:00Z The commissioner's office said Thursday he tested positive for metabolites of Stanozolol. Minnesota Twins outfielder Reynaldo Rodriguez has been suspended 80 games following a positive test under baseball's minor league drug program 2016-04-28T04:00:00Z It reduces the level of a metabolite called carnetine in muscles, and by doing that helps muscles cope better with high levels of stress and low oxygen levels. Experts perplexed over why Sharapova was taking banned heart drug 2016-03-09T05:00:00Z Another possibility is to target the microbial enzymes that produce metabolites with inhibitors. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The first is composed of primary metabolites, which are molecules produced by the catabolic and anabolic reactions that are required for cellular growth and homeostasis. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Zarate is particularly encouraged by the fact that the metabolite he found doesn’t seem to activate the pathway that’s responsible for ketamine’s addictive effects as well. ‘Club Drug’ Ketamine Provides Hope Against Depression 2016-05-11T04:00:00Z Other studies indicate that children who eat organic foods have lower levels of pesticide metabolites in their bodies than those who eat conventional. Why Organic Food Might Be Worth the High Price 2016-02-04T05:00:00Z That may have implications for doctors as well as athletes, because the metabolites and electrolytes that the human body secretes in sweat can be used to determine muscle fatigue as well as hydration levels. This headband analyzes your sweat to improve your workout 2016-01-27T05:00:00Z However, such inhibitors are yet to be tested in humans, and it is unlikely that one metabolite acts alone to promote or prevent metabolic diseases. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The third group is composed of metabolites produced by cells of the host or from exogenous sources that are directly modified by microbial enzymes to create unique chemical products. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The researchers found a significant correlation between lower exhalation rates -- roughly equivalent to about 8% less air -- and higher levels of organophosphate metabolites. Pesticides as bad for kids' lungs as cigarette smoke, study says 2015-12-03T05:00:00Z It isn’t just that Robles tested positive two years ago for an anabolic steroid and/or its metabolites. Disgraced Weightlifter Picks Herself Back Up 2015-11-19T05:00:00Z What about the cells' metabolites and other biochemistry? Deep phenotyping: The details of disease : Nature : Nature Publishing Group 2015-11-03T05:00:00Z This causes these desirable metabolites to build up in the fruit. Gene-modified Tomatoes Churn Out Healthy Nutrients 2015-11-02T05:00:00Z For instance, the risk of colon cancer in mice increases in the presence of particular strains of Escherichia coli that express a gene cluster that produces a genotoxic secondary metabolite called colibactin15. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z For example, individuals who are homozygous for inactive CYP2D6 alleles are unable to convert the analgesic drug codeine into its active metabolite, morphine, but can respond to several other opiate analgesics27. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z Researchers are starting to uncover a vast, varied system in which gut microbes influence the brain through hormones, immune molecules and the specialized metabolites that they produce. The tantalizing links between gut microbes and the brain 2015-10-13T04:00:00Z The result was a law that covered not just vitamins and minerals, but botanicals, amino acids, enzymes, metabolites and pills made from animal organs. Miracle healers 2015-09-17T04:00:00Z We feed the drug to them and identify metabolites from that process. Fake Weed Leads to a Real Drug Crisis 2015-08-25T04:00:00Z “Confirmation of ovulation using the fecal progesterone metabolite levels allowed us to predict the next potential window for her to mate again,” Keeley says. Poop Could Help Save Rare Tree Kangaroo from Extinction 2015-08-20T04:00:00Z This is because these patients produce much lower levels of the active tamoxifen metabolite, endoxifen, than those without defective alleles30, 31, 32, 33, 34, 35. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z But extensive testing of metabolites and gene expression show significant abnormalities in the CSF/ME patient population that need to be studied in greater depth, he says. Lobbyists seek $250 million in new funds for chronic fatigue syndrome research 2015-08-17T04:00:00Z The scientists recorded levels of cortisol and its metabolites, including 5-alpha reductase, before and after prolonged exposure therapy and at three-month follow-up appointments. Who Benefits Most from PTSD Treatment? 2015-08-03T04:00:00Z We capture all ions present in a single sample and then analyze what metabolites are present. Fake Weed Leads to a Real Drug Crisis 2015-08-25T04:00:00Z Consistent with that account, a test found no THC in her blood, but it did detect inactive metabolites, which was enough to charge her with a felony punishable by up to 14 years in prison. A 'Drugged Driver' Who Wasn't Avoids Prison 2015-07-21T04:00:00Z “It looks like this protein that’s part of your immune system is able to use metabolites in the diet as grips to hold onto iron and keep it away from pathogenic bacteria,” Henderson says. Here's Why Your Diet May Be Causing Your Nasty UTI 2015-06-30T04:00:00Z Most of that — about 80 to 90 percent — is converted into a metabolite called BPA-Glucuronide, which is eventually excreted. BPA May Break Down into Fat in Human Body 2015-05-29T04:00:00Z “It’s possible that there might be an increase in certain metabolites after a massage,” Dr. Perlman said. Ask Well: Massage and Toxins 2015-05-22T04:00:00Z Some research suggests that the high iron content in red meat promotes carcinogenesis by increasing cell growth, and others indicate that one of alcohol's metabolites can interact directly with DNA. Prevention: Tending the gut : Nature : Nature Publishing Group 2015-05-12T04:00:00Z More than two dozen of these metabolites were highly correlated with diet. Coming Soon: A Test to Gauge Your Obesity Risk? 2015-04-30T04:00:00Z The study revealed how naphthalene is converted by the liver into metabolites that cause cell damage and death in the lung — even though naphthalene itself is relatively harmless to this organ. Artificial organs: Honey, I shrunk the lungs : Nature : Nature Publishing Group 2015-03-24T04:00:00Z Researchers believe BPA does so by mimicking estrogen hormones, but its metabolite doesn’t appear to do so. BPA May Break Down into Fat in Human Body 2015-05-29T04:00:00Z However, they break down into metabolites that persist and still exhibit endocrine disrupting properties. Hormone-Mimicking Chemicals Found throughout Great Lakes 2015-03-23T04:00:00Z The changes include a drop in brain volume, loss of myelin integrity, cortical thinning, impaired receptor binding and signalling, and altered concentrations of various brain metabolites. The upside of losing one's memory 2015-03-13T04:00:00Z Another metabolite described as a sign of consumption of red meat was also linked to a high BMI. Coming Soon: A Test to Gauge Your Obesity Risk? 2015-04-30T04:00:00Z The animals developed leaky intestines, their immune systems activated, and they produced a barrage of pro-inflammatory metabolites, many with known nervous system effects. Mental Health May Depend on Creatures in the Gut 2015-03-02T05:00:00Z BPA-Glucuronide is “not an inactive metabolite as previously believed but is in fact biologically active,” the Health Canada authors wrote in the study published this week in Environmental Health Perspectives. BPA May Break Down into Fat in Human Body 2015-05-29T04:00:00Z Meanwhile, scientists fear the biologically active contaminants and their metabolites may alter the hormones of fish and other aquatic creatures, leading to reproductive, behavioral and developmental problems. Hormone-Mimicking Chemicals Found throughout Great Lakes 2015-03-23T04:00:00Z They often specialize in fermenting dietary fiber that we cannot digest and produce by-products, or metabolites, that appear to be important for gut health. Among Trillions of Microbes in the Gut, a Few Are Special 2015-02-25T05:00:00Z Since 1996, the Bermuda principles have been extended to other types of sequence data and to other fields that generate large data sets, such as metabolite research. Data sharing: Make outbreak research open access 2015-02-24T05:00:00Z Finally, studies monitoring the epigenomic changes that arise as a result of ageing and of changes in environmental factors such as nutrients and metabolites will also be interesting. Epigenomics: Roadmap for regulation : Nature : Nature Publishing Group 2015-02-17T05:00:00Z A large number of metabolic trait variants are enriched in liver enhancer marks, including LDL, HDL, total cholesterol, lipid metabolism phenotypes, and metabolite levels83, 84. Integrative analysis of 111 reference human epigenomes : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Metabolomics is an emerging branch of science that focuses on metabolites, the substances produced through digestion and other bodily processes. Looking for that fruit or vegetable that might prevent cancer? 2015-02-13T05:00:00Z Some of the cells that line our colon derive nourishment directly from these metabolites, not from the bloodstream. Among Trillions of Microbes in the Gut, a Few Are Special 2015-02-25T05:00:00Z Edwards, on the roster of Bowling Green of the Class A Midwest League, tested positive for Dehydrochloromethyltestosterone and metabolite, Methasterone and metabolite, and a metabolite of Tamoxifen. 3 minor leaguers suspended for positive drug tests 2015-02-13T05:00:00Z "This work provides a foundation for safer GMOs that are isolated from natural ecosystems by a reliance on synthetic metabolites." 'Safer GMOs' made by US scientists 2015-01-21T05:00:00Z “We will do our best to get a clear answer about whether or not there are detectable components and metabolites in the blood of children taking the medicine,” he said. Scrutiny for a Childhood Remedy 2015-01-05T05:00:00Z Prometheus decision, which invalidated a patent on a method of adjusting drug dosage using measures of blood metabolites because it relied on a “law of nature.” U.S. patent office floats new biotech-friendly guidelines 2014-12-19T05:00:00Z Our immune systems quiet down when they receive signals, conveyed partly in microbial metabolites, indicating that the right microbes are in place. Among Trillions of Microbes in the Gut, a Few Are Special 2015-02-25T05:00:00Z The researchers measured levels of the metabolites of four phthalates in the mothers’ urine when they were pregnant, and children were given IQ tests at age 7. Phthalates Are Linked to a Drop in IQ 2014-12-10T05:00:00Z “I do think there is a different concentration of metabolites in the first portion of a urine stream,” says Conte. The Stream is Over: A-Rod Admits to Manipulating Drug Tests 2014-11-05T05:00:00Z In recent years, scientists have been methodically working out how to interpret useful compounds they’ve found in cetacean blow, which include DNA, microbes, metabolites, and hormones. A Breathalyzer for dolphins? 2014-10-24T04:00:00Z Urine tests look for a metabolite, or bodily by-product of THC, the chemical that accounts for many of marijuana’s psychoactive properties. Could Second-Hand Pot Smoke Make You Fail a Marijuana Test? Yet the seeming importance of these metabolites has others puzzled. Among Trillions of Microbes in the Gut, a Few Are Special 2015-02-25T05:00:00Z He and two chemists teamed up to study tiny quantities of drug metabolites in sewage, measuring parts per billion with a state-of-the-art mass spectrometer. US city considers testing sewage to gather data on residents' marijuana use 2014-09-26T04:00:00Z The researchers discovered this by scouring metabolites in the women’s urine and then tracking their children via questionnaires and physicians’ diagnoses. Could Air Fresheners During Pregnancy Boost Childhood Asthma Risk? 2014-09-17T04:00:00Z One possibility is that the metabolites of synthetic cannabis are also doing damage to the brain. 6 Reasons Synthetic Marijuana (Spice, K2) Is So Toxic To The Brain 2014-08-28T04:00:00Z Technological advances that allowed researchers to catalogue proteins, metabolites, genetic variants and gene activity led to a spate of associations between molecular states and health conditions. Microbiology: Microbiome science needs a healthy dose of scepticism 2014-08-19T04:00:00Z Various rodent studies suggest that these metabolites, called short-chain fatty acids, can induce Tregs and calibrate immune function in ways that, over a lifetime, may prevent inflammatory disease. Among Trillions of Microbes in the Gut, a Few Are Special 2015-02-25T05:00:00Z Khan analyzed the breast tissue after surgery to study markers for tumor growth, and conducted blood tests for levels of tamoxifen metabolites as well. Treating Breast Cancer With a Gel? It May Be Possible 2014-07-15T04:00:00Z They searched for both the drugs themselves, as well as some of their metabolites—the compounds that result from the drug’s transformation in the body. Sewer Sludge Can Reveal Which Drugs a Community Is On, and When Eucalyptus also shows the highest diversity of genes for specialized metabolites such as terpenes that act as chemical defence and provide unique pharmaceutical oils. The genome of Eucalyptus grandis : Nature : Nature Publishing Group 2014-06-10T04:00:00Z Researchers tested for metabolites that the body produces after ingesting drugs to be certain the substances had been “consumed, not flushed,” Ort says. Europe Samples Sewage Water to Find Its Biggest Drug Cities 2014-05-28T04:00:00Z So far they found about 30 metabolites that were at elevated levels in obese guts and about 20 that were elevated in lean guts. Bioengineer is working to make E. coli fight obesity, depression 2014-05-24T04:00:00Z Huang and her colleagues deduced that because aging depends on metabolism, compounds produced in cells by metabolic reactions—known as metabolites—might also boost lifespan. Cellular Compound May Increase Lifespan Without the Need for Strict Dieting 2014-05-14T04:00:00Z Over the course of one week, they monitored changes in metabolite levels in the waste. Sewer Sludge Can Reveal Which Drugs a Community Is On, and When It is generally thought that the extremely diverse array of secondary metabolites observed within Eucalyptus defends against a comparably diverse array of biotic pests, pathogens and herbivores encountered across its natural range. The genome of Eucalyptus grandis : Nature : Nature Publishing Group 2014-06-10T04:00:00Z Implanted in the body, these designer cell communities would monitor disease-relevant metabolites in the blood and coordinate the production and release of a therapeutic compound as the body needed it. Synthetic biology: How best to build a cell 2014-05-06T04:00:00Z Avoiding the pitfalls of asking study participants to record or recall their daily intake, the researchers regularly gathered specimens of subjects’ urine and tested them for levels of resveratrol metabolites. Ingredient in red wine and chocolate may be no help fighting disease, study says 2014-05-13T04:59:48Z The researchers looked at urine samples of 783 people living in the Chianti region of Italy and measured levels of resveratrol metabolites. New Study Questions Benefit Of Chocolate And Red Wine Antioxidant 2014-05-13T02:30:00Z In the lab, the bacteria will be sequenced and counted and the urine analyzed for particular metabolites. Antibiotics Overload Is Endangering Our Children 2014-05-09T04:01:50Z Gut bacteria in the simulated colon then broke that down further into metabolites, small enough to be absorbed into the bloodstream and known to reduce cardiac inflammation. Well: Why Chocolate Is Good for Us 2014-04-24T04:01:55Z Arizona is one of at least seven states that has a zero-tolerance ban on driving with any controlled substance or its metabolite in the body, according to the dissenting opinion in the case. Arizona high court rules pot users must be impaired for DUI charge 2014-04-23T00:32:06Z “If a cell needs certain metabolites to grow, it will find a way.” Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z The treatment led to substantially lower levels of a cancer metabolite in the blood called 2HG that researchers believe reprograms white blood cells, stripping their ability to become infection fighters. Agios leukemia drug shows promise in tiny, early study 2014-04-06T14:31:35Z RA is a vitamin A metabolite that controls early vertebrate development, some immune processes in adulthood, and has been shown to mediate CXCL13 expression in fetal mesenchymal cells. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity 2014-04-04T18:28:57.531Z The patents covered the act of measuring metabolites to determine the proper dosage of certain drugs used to treat autoimmune diseases. Software patents await legal fate 2014-03-26T18:20:19.979Z A blood test revealed he had the cannabis metabolite Carboxy-THC in his system. Arizona high court rules pot users must be impaired for DUI charge 2014-04-23T00:32:06Z Now chemists at the University of Texas in Arlington believe they have developed a method that builds on existing mass spectrometry techniques to detect these extremely small metabolites. New doping test '1,000 times better' 2014-03-19T00:14:48Z Congeners include acetaldehyde itself as well as acetone, fusel oil, furfural, methanol's metabolites, polyphenols, histamines, esters, tannins, amines and amides, among others. In Search of a Cure for the Dreaded Hangover 2014-03-17T11:00:00Z A wide array of research during the past few years has shown that PBDEs and their metabolites—what is left over when they break down in the body—are generally bad news. What You Need to Know about Flame Retardants 2014-03-02T13:30:00Z Stool is a variable, complex mixture of microbes, metabolites and human cells. Policy: How to regulate faecal transplants 2014-02-19T18:50:53.475Z Sometimes the metabolites of the drug – the molecules that it changes into after it is oxidized – are themselves as powerful as the drug. Why drug discovery is hard – Part 4: Taking the fight to the “enemy”. 2014-02-05T17:20:45Z This observation suggests the presence of as yet unidentified metabolites produced by ‘’. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z These scientists also said the second metabolite, acetate, may provide protective health effects associated with the regular moderate consumption of alcohol. In Search of a Cure for the Dreaded Hangover 2014-03-17T11:00:00Z Saliva samples to test for caffeine and its metabolites were collected after 1, 3 and 24 hours. Should you drink coffee before or after a learning task? 2014-01-14T17:45:04.184Z Conditions ranging from inflammatory bowel diseases and obesity to asthma and cancer have been linked to its composition, with associations described between gut bacteria, biologically active metabolites and the immune system. Policy: How to regulate faecal transplants 2014-02-19T18:50:53.475Z SLC16A11 is part of a family of genes that code for proteins that transport metabolites - molecules involved in the body's various chemical reactions. Diabetes risk 'from Neanderthals' 2013-12-25T18:27:13Z For all cases, positive wells were identified, suggesting that TSY1 carries the plasmid and produces the entire set of metabolites. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z However, the metabolome is very difficult to measure at the single-cell level because of rapid metabolic dynamics, the structural diversity of the molecules, and the inability to amplify or tag small-molecule metabolites. [Special Issue Review] Single-Cell Metabolomics: Analytical and Biological Perspectives 2013-12-05T18:56:42.368Z Image: Flickr/Gates Foundation DDT and its metabolites are all-but indestructible; they accumulate in the Arctic and concentrate atop food chains. Malaria Mosquitoes Gain Ground as Search for New Defenses Intensifies 2013-07-29T17:15:01.010Z An algorithm derived from clinical features together with measurements of five metabolites predicted patient survival. [Research Articles] An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis 2013-07-24T19:25:07.917Z But with multiple experiments that produce diverse data — on gene expression, metabolites and protein abundance, for example — we need something more sophisticated. Biology must develop its own big-data systems 2013-07-03T17:20:04.997Z Compound localization studies suggested Bacteria as producers of individual metabolites, but remained ambiguous owing to the possibility of sequestration or transport. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z The fact that single-cell measurements exhibited a much larger spread in metabolite concentrations than population measurements was exploited to determine many metabolite-metabolite correlations, which were altered in 2DG-treated yeast cells relative to controls. [Special Issue Review] Single-Cell Metabolomics: Analytical and Biological Perspectives 2013-12-05T18:56:42.368Z "This study is exceptionally strong because historical measurements of a trichloroethylene metabolite in humans are available to document the exposure," said Ward, who was not involved in the study. Common solvent linked to liver cancer risk 2013-06-06T18:56:26Z Nonetheless, the fact that metabolites of the cannabis were found in Martin’s blood made national headlines when it was first made public. Viewpoint: Marijuana's Ever-Changing Image 2013-06-02T20:35:25Z Nolan plans to analyze tissue using mass spectrometry to look for toxicants or metabolites. Bizarre 6-Inch Skeleton Shown to Be Human 2013-05-03T23:40:00Z Consensus spectra were annotated by comparison with a database of published secondary metabolites from T. swinhoei. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z She studies plant cellular biology and hopes to work for a PhD in plant biochemistry or secondary metabolites. Phytochemical Pharmacy: The Healing Potential of Plants 2013-04-15T18:45:06.090Z Noah Fierer: Our body odor is a product of microbial metabolites. Ten Predictions for the Future of Your (Microbial) Health 2013-03-19T12:45:03.283Z Metabolomics enabled them to study the metabolites from biochemical reactions inside bacteria to access the 'chemical fingerprint' of cellular reactions involving metals. Microbiology: There's gold in them there bugs 2013-03-13T18:21:17.547Z The advantage of testing blood is that it more often reflects the parent drug, rather than metabolites, and that it reflects more “real-time” use. Drug screens-any more than theater? 2013-02-19T15:45:00.433Z This observation suggests the presence of as yet unidentified metabolites produced by ‘’. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z The types of molecules most often employed by plants in their defences are called secondary metabolites, because they are made using supplementary reactions, which are usually the continuation of a pathway. Phytochemical Pharmacy: The Healing Potential of Plants 2013-04-15T18:45:06.090Z Jia first began to suspect microbes after he and his colleagues noticed that metabolites produced by gut bacteria in rats are different after exposure to melamine. Gut Bacteria Conspired in Melamine Poisonings 2013-02-13T19:00:00Z The finding, the team notes, is the first demonstration that a secreted metabolite can protect against toxic gold and cause gold biomineralization. Microbiology: There's gold in them there bugs 2013-03-13T18:21:17.547Z Golden genes Using biochemical and genome analysis, the researchers discovered a set of genes and a chemical metabolite that were responsible for precipitating the gold. Bacteria Found to Thrive on Gold 2013-02-04T17:15:06.787Z This observation suggests the presence of as yet unidentified metabolites produced by ‘’. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z Hazen stumbled across one of these surprising mechanistic pathways a few years ago while looking for metabolites linked to atherosclerosis. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z “All these metabolites and their interactions paint a portrait of the state of that individual,” explains Promislow. Comparative biology: Looking for a master switch 2012-12-06T12:21:16.843Z Flower color in dahlias is determined by a mixture of plant metabolites called flavonoids. How Rare Black Dahlias Get Their Color 2012-11-27T18:45:00.283Z More complex community contributions also exist, such as interactions with host immune and inflammatory systems or production of metabolites involving hybrid pathways from multiple organisms, including host–microbe pathways. Genomic approaches to studying the human microbiota 2012-09-13T11:21:35.367Z These feedback loops may involve the accumulation of a phage specific to that microbe or the accumulation of a specific toxic metabolite. Diversity, stability and resilience of the human gut microbiota 2012-09-13T11:20:47.313Z Some were metabolites that could only be produced by bacteria. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z A 2010 paper in Pediatrics, for instance, found higher levels of pesticide metabolites in the urine of children with ADHD. Is Organic Food Better? 2012-09-04T16:28:00Z They then used that timetable to determine the internal body times of other subjects by checking the levels of the metabolites in just two blood samples from each subject per day. What Time Is it on Your Circadian Clock? 2012-08-27T20:10:00Z We appreciate the opportunity here to recount our experimental design details and, like Löffler et al., we stress the necessity of controlling for effects potentially mediated by CNO alone and/or its metabolites. [Technical Response] Response to Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition” 2012-08-10T14:26:23.917Z About £2.5m is being used to build a biomarker facility, housing three new mass spectrometers to measure proteins, lipids and metabolites in blood. Record £7m gift for university 2012-08-09T05:06:04Z Hazen and colleagues found that the metabolite increases the number of receptors on the surface of macrophages that bind to LDL, which makes the cells more prone to gobble up cholesterol. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z Blood and urine tests for calcium and other bone metabolites confirmed that as long as they were taking the estrogen, they lost less bone. Cracks in the Test: Doctors Improve Osteoporosis Screens 2012-08-06T12:15:00.413Z A phenome describes all of a person's physiological traits in the same way that a genome describes genetic features; metabolic phenotyping focuses on metabolites, the products of chemical reactions inside the body. Olympic Drug Testing Lab to Become National Phenome Center 2012-08-01T16:01:04Z Johnson was sent home in disgrace after metabolites of the anabolic steroid were found in his urine sample following his victory over Carl Lewis in the 100 meters final in world record time. Albanian Pulaku becomes first doping cheat 2012-07-28T12:05:09Z Two of the most important kinds of secondary metabolites are alkaloids and terpenes, both of which have been used by humans for centuries as drugs, fragrances, pesticides and food. Gene duplication frees up enzymes for molecular promiscuity 2012-07-28T11:45:06.120Z Mobile devices offer remarkably attractive low-cost, real-time ways to assess disease, movement, images, behavior, social interactions, environmental toxins, metabolites and a host of other physiological variables. The Real Promise of Mobile Health Apps 2012-07-10T12:45:02.163Z “That meant we included my RNA, my proteins, my metabolites and my autoantibodies.” Novelties: Geneticist’s Research Finds His Own Diabetes 2012-06-02T19:26:21Z While the males had high levels of a stress hormone known as cortisol and low levels of the metabolite of the mood-related neurotransmitter serotonin, this difference was not seen in females. The Measure of a Mother's Love: How Early Deprivation Derails Child Development 2012-05-24T12:05:43Z One, for instance, blames the metabolites and other chemicals excreted by the bacteria. Microbiome: The critters within 2012-05-22T15:21:14.643Z Alkaloids include strychnine, morphine and caffeine and terpenes include menthol, cholesterol and vitamin A. Antibiotics are also secondary metabolites. Gene duplication frees up enzymes for molecular promiscuity 2012-07-28T11:45:06.120Z The natural law in question was the relationship between thiopurines, which are drugs used to treat gastrointestinal disorders, and metabolites in patients’ blood. Justices Reject Patents for Medical Tests Relying on Drug Dosages 2012-03-20T22:57:17Z Dr. Church looks forward to the day when current research becomes a routine clinical procedure that combines inherited genomic information with analyses of RNA, proteins, metabolites and microbes in our bodies. Novelties: Geneticist’s Research Finds His Own Diabetes 2012-06-02T19:26:21Z In another study published last year, they pinpointed another set of genes that may have funneled more energy to brains, and less to muscles — this time in the form of a metabolite called creatine. How Did Human Brains Get to Be so Big? 2012-02-21T18:15:16.457Z Faeces gathered during the 2001 period of light shipping showed a significantly lower level of metabolites of glucocorticoid hormones, which are associated with stress, than in subsequent summers when marine traffic returned to normal levels. Whales 'stressed by ocean noise' 2012-02-08T03:28:20Z We are looking for arsenate in the metabolites, as well as the assembled RNA and DNA, and expect others may be doing the same. Study Fails to Confirm Existence of Arsenic-Based Life 2012-01-23T15:45:00.257Z The science that looks at the body's metabolite composition is known as metabolomics. New Target Discovered for Pain Relief 2012-01-23T03:15:00.427Z Relative 2HG levels from pathologically confirmed mutant tissues correlated with levels of other ex vivo metabolites and histopathology parameters associated with increases in mitotic activity, relative tumor content, and cellularity. [Research Articles] Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas 2012-01-11T20:25:08.257Z This systemic view is the key difference between metabonomics and the standard scientific approach to examining metabolites using cell cultures. Microbiome: That healthy gut feeling 2011-12-21T18:20:57.373Z A systems biology investigation of the two groups found statistically significant differences between them in the expression of genes related to apoptosis and metabolite profiles. Perspective: All systems go 2011-12-21T18:20:56.003Z In 2004 Mayo developed a competing test, with different recommended levels of metabolites. Biotech patents: Taking it personally 2011-12-08T16:17:06Z The patent in question concerns the relationship between thiopurines, which are drugs used to treat gastrointestinal disorders, and metabolites in patients’ blood. Justices Consider Patents for Individualized Medicine 2011-12-08T03:56:36Z Doctors are told to monitor patients taking the medication for certain metabolites in red blood cells, with the goal of hitting certain levels to assure patients the best treatment with the fewest side effects. Supreme Court to hear personal medicine dispute 2011-12-07T16:20:04Z Giving people chamomile, for example, changes the metabolite make-up of their urine. Microbiome: That healthy gut feeling 2011-12-21T18:20:57.373Z Bacteria on housefly eggs, Musca domestica, suppress fungal growth in chicken manure through nutrient depletion or antifungal metabolites. Fly on wall sees things it wishes it hadn't 2011-10-24T18:15:12.940Z But the patents cover the process for determining whether a given dose produces concentrations of metabolites within a recommended range. Biotech patents: Taking it personally 2011-12-08T16:17:06Z With the expansion in high-throughput sequencing of genomes, proteins and metabolites, programmes that focus on a single area, such as genomics, don't adequately prepare students for the job market, says Brunak. Education: Inspiration for informatics 2011-10-06T10:50:30.753Z But the amounts of these metabolites are small. Dr Dillner's health dilemmas: should I give up fizzy drinks? 2011-08-22T20:00:01Z But the team saw DDT and its metabolites in placentas they studied, and found a similar relationship between DDT levels and the risk of certain fetal defects seen with PAHs. Neural-Tube Birth Defects Tied to Organic Pollutants 2011-07-18T23:45:04.793Z As the heterotrophs degraded the carbon-rich layers produced by photosynthesis, she says, they excreted metabolites that caused the pH in the mat to rise. Microbial Mat Bears Direct Evidence of 3.3 Billion-Year-Old Photosynthesis 2011-07-06T19:45:00.520Z The known biosphere's metabolites and informational molecules are built from carbon, hydrogen, oxygen, nitrogen, and phosphorus, but alternatives are certainly possible, especially given the spectacular power of natural selection. From the shadows to the spotlight to the dustbin - the rise and fall of GFAJ-1 2011-06-16T13:15:02.533Z Helm's group uses advanced mass spectrometry techniques to explore complex biological problems such as cell-cell communication, focusing on quantification of proteins and metabolites. Cells Talk to One Another, but How? 2011-06-14T13:55:00Z These downstream biochemical pathways may require the more chemically stable P-based metabolites; the lifetimes of more easily hydrolyzed As-bearing analogs are thought to be too short. [Research Article] A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus 2011-06-02T18:26:22.637Z It is regulated by a group of nerve fibers, the so-called ergoreceptors, that respond to a combination of metabolites released by muscles during exercise — calcium ions, lactate, hydrogen ions. Personal Best: One Runner?s Suffering Is Another?s Inspiration 2011-05-16T15:12:59Z For the study, the teams measured metabolites -- chemical byproducts of foods in the body. US study probes how surgery makes diabetes disappear 2011-04-27T19:41:31Z And in the third study, babies whose mothers had high levels of pesticide metabolites in their urine scored lower on cognitive tests beginning at 12 months, and their reasoning abilities remained subpar throughout childhood. Health Buzz: Prenatal Pesticide Exposure Linked to Lower IQ 2011-04-21T14:55:00Z It is a disease that affects a large number of metabolites, which are the foundation of the body's fuels. Mouse Study Reveals Mechanism behind Diabetes Blood Vessel Damage 2011-02-18T15:15:04.180Z We caution that the large “protein” fraction is probably an overestimate because this extraction step likely contains numerous small, non-proteinaceous metabolites as well. [Research Article] A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus 2011-06-02T18:26:22.637Z Dr. Light and Dr. Amann showed the effects of the two types of nerve fibers by injecting muscle metabolites into the muscle at the base of subjects’ thumbs. Personal Best: One Runner?s Suffering Is Another?s Inspiration 2011-05-16T15:12:59Z Elucidating its complexity will require a more systems-level approach, including comprehensive integration with other data dimensions, such as RNA, metabolite, protein, and clinical data. [Essay] Genome-Sequencing Anniversary: First Steps on a Long Road 2011-02-11T22:25:50.493Z For example, although we are all in a state of homeostatic equilibrium, the 'normal' levels of metabolites, including glucose, plasma proteins, cytokines and signalling molecules, vary from person to person. Technology: A flavour of the future 2011-01-04T22:23:01.467Z Metab-olomics, or the study of these metabolites, offers perhaps the best opportunity to observe these interactions in a minimally invasive manner. Health: Edible advice 2011-01-04T22:22:47.507Z By monitoring hundreds of other metabolism-related proteins and metabolites of blood cells and adipose tissue, the team identified more than 500 other diet-driven changes. Interdisciplinary research: Big science at the table 2011-01-04T22:22:24.870Z The glucocorticoid metabolite levels in the collected dung reflect an average of levels over the previous 30 hours, the time it takes for food to pass through an elephant's stomach. Crop raiding elephants 'stressed' 2010-12-14T10:04:12Z It found that concentrations in urine of all three metabolites are significantly higher in people receiving blood transfusions. AP source: Contador samples show plastic residues 2010-10-05T15:22:00Z For this they collect the homogenized center of the fecal sample, which contains the relatively stable hormonal metabolites. Collecting Monkey Dung 2010-09-28T18:30:00Z Eskenazi's team tested for levels of pesticide metabolites in urine in the mothers twice during their pregnancies and several times in the children after birth. More data connecting pesticides to ADHD 2010-08-20T04:16:00Z They looked for breakdown products or metabolites from pesticides in urine samples from the mothers during pregnancy and from their children as they grew. Study links pesticides to attention problems 2010-08-19T07:15:00Z Scientists found high levels of glucocorticoid metabolites in dung collected from crop raided fields. Crop raiding elephants 'stressed' 2010-12-14T10:04:12Z Both are in the Dominican Summer League, and both tested positive for metabolites of Stanozolol. 2 more minor leaguers suspended 50 games 2010-08-04T15:00:00Z The study was designed primarily to correlate how well levels of the chemicals in cigarettes correlate with levels of their metabolites in smokers' urine. CDC: American cigarettes contain more carcinogens 2010-06-02T00:02:00Z First, in 70 healthy people put on a treadmill, the team found more than 20 metabolites that change during exercise, naturally produced compounds involved in burning calories and fat and improving blood-sugar control. Study: 10 minutes of exercise, hour-long effects 2010-05-31T17:31:00Z Overall, the researchers found that higher levels of metabolites from two VOCs -- toluene and xylene -- were related to poorer lung function. Indoor chemicals may affect elderly's lung function 2010-04-09T17:15:00Z In 2006, he and a team of collaborators began a survey of the metabolites of thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z We had Leduc and his "fairy flowers," as now we have Loeb and others with their metabolites and hormones. Science and Morals and Other Essays Higher levels of VOC metabolites were related to higher levels of oxidative-stress markers, and increases in those markers, in turn, were related to poorer lung function. Indoor chemicals may affect elderly's lung function 2010-04-09T17:15:00Z For example, Muoio discovered the muscles of diabetic animals lack enough of a metabolite named carnitine, and that feeding them more improved their control of blood sugar. Study: 10 minutes of exercise, hour-long effects 2010-05-31T17:31:00Z Moreover, the findings point to an association between VOC metabolite levels and lung function -- but do not prove that the chemicals directly impair lung function. Indoor chemicals may affect elderly's lung function 2010-04-09T17:15:00Z As they described in a report last year, they found that only one metabolite they tested, known as CPS49, caused the chicks to fail to develop wings. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z |
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