| 单词 | messenger RNA |
| 例句 | Notably, Brenner and Jacob later discovered the messenger RNA was a facsimile of the DNA chain—a copy made from the original. The Gene 2016-06-02T00:00:00Z The messenger RNA was neither an inhabitant of heaven nor of hell—but a professional go-between. The Gene 2016-06-02T00:00:00Z Ribosomes are crucial machines inside the cytoplasm of all cells that read the genetic instructions on messenger RNA and build chains of amino acids that fold into proteins. Peering inside cells to see how they respond to stress 2023-10-16T04:00:00Z The gene codes for a protein, ANP32A, that normally plays a role in transcribing DNA into messenger RNA. In ‘proof of concept,’ CRISPR-engineered chickens shrug off flu 2023-10-10T04:00:00Z The messenger RNA approach starts with a snippet of genetic code-carrying instructions for making proteins. Gates Foundation funding $40 million effort to help develop mRNA vaccines in Africa in coming years 2023-10-09T04:00:00Z The messenger RNA approach starts with a snippet of genetic code carrying instructions for making proteins. Gates Foundation funding $40 million effort to help develop mRNA vaccines in Africa in coming years 2023-10-09T04:00:00Z When we started here at BioNTech, injecting messenger RNA coding for cytokines, by that time, the human trial using mRNA for cancer vaccines had already been going on for years. An mRNA Pioneer Discusses How Her Work Led to the COVID Vaccines 2023-10-02T04:00:00Z She was exploring DNA’s use of messenger RNA to deliver specific work orders to cells when she met Weissman over a photocopy machine at the University of Pennsylvania in 1997. Scientists whose work on mRNA paved the way for first COVID-19 vaccines win Nobel Prize 2023-10-02T04:00:00Z During transcription, the cell takes the DNA master blueprint and makes a copy of the genetic instructions known as messenger RNA or mRNA. Improvements in human genome databases offer a promising future for cancer research 2023-09-21T04:00:00Z The main options from Pfizer and Moderna deploy messenger RNA, which teaches the body how to recognize the virus and mount an immune response. FDA approves updated boost shot for COVID-19 ahead of fall campaign 2023-09-11T04:00:00Z Some teams are trying to use the same lipid nanoparticles, or fat bubbles, employed in the messenger RNA COVID-19 vaccines as a delivery vehicle for RNA encoding the gene editor’s molecular components. Muscular dystrophy gene therapy nears approval, but safety concerns linger 2023-05-23T04:00:00Z Next, the researchers compared these fish’s gastrointestinal tracts with those of fish they had injected with pieces of messenger RNA encoding an enzyme that reactivates the disabled telomerase gene in the gut. Scientists prevent signs of aging in zebrafish by targeting the gut 2023-05-18T04:00:00Z Weissman knew that messenger RNA had an incidental effect on dendritic cells: Their interaction touched off an immune response that ignited dangerous inflammation across the body. Scientists whose work on mRNA paved the way for first COVID-19 vaccines win Nobel Prize 2023-10-02T04:00:00Z The messenger RNA is then shuttled over to a ribosome, a tiny protein factory within the cell, to start the process of translation. Improvements in human genome databases offer a promising future for cancer research 2023-09-21T04:00:00Z Alpha amanitin wreaks havoc in the body by mucking up the cells’ ability to make messenger RNA. In Search of an Antidote for Poisonous Mushrooms 2023-05-16T04:00:00Z Food and Drug Administration on Tuesday withdrew its emergency use authorization for older messenger RNA vaccines by Moderna Inc and Pfizer-BioNTech / as it now recommends the use of newer Omicron-targeting shots for all doses. French shipper CMA CGM offers $5.5 bln for Bollore logistics unit 2023-04-18T04:00:00Z Food and Drug Administration on Tuesday withdrew its emergency use authorization for older messenger RNA vaccines by Moderna Inc and Pfizer-BioNTech / as it now recommends the use of newer Omicron-targeting shots for all doses. More US consumers are falling behind on payments 2023-04-18T04:00:00Z The next morning, together with researchers at NIH, McLellan began to engineer the virus’ spike gene into the messenger RNA vaccine that Moderna later developed. Dispute simmers over who first shared SARS-CoV-2’s genome 2023-03-28T04:00:00Z The vaccines use messenger RNA, which injects a snippet of genetic code — encased in a bubble of fat — to instruct the body on how to recognize and combat the virus. Moderna CEO defends COVID vaccine price hike, citing pivot to endemic phase 2023-03-22T04:00:00Z The jabs use a molecule of genetic code called messenger RNA to generate an immune response. China approves first home-grown mRNA Covid vaccine 2023-03-22T04:00:00Z It chose instead to promote its own pharmaceutical firms, first in rolling out a more traditional but less effective Covid vaccine, and later, in the pursuit of a homegrown mRNA, or messenger RNA, vaccine. China Approves an mRNA Covid Vaccine, Its First 2023-03-22T04:00:00Z Gilbert and other researchers are working on other delivery methods, such as messenger RNA — the technology used in many vaccines for the coronavirus — to deliver a genetic payload to the nucleus of cells. New gene therapy approaches show ‘breakthroughs’ against rare condition 2023-02-24T05:00:00Z Gilbert and other researchers are working on other delivery methods, such as messenger RNA – the technology used in many COVID-19 vaccines – to deliver a genetic payload to the nucleus of cells. Promising gene therapy delivers treatment directly to brain 2023-01-23T05:00:00Z That progress continues: The coronavirus pandemic heralded the coming of effective and flexible messenger RNA vaccines that may prove invaluable in the fight against many types of viruses. Lab-leak fears are putting virologists under scrutiny 2023-01-18T05:00:00Z Beijing has not authorized the mass use of Western-made messenger RNA vaccines, which studies have shown are significantly more effective than Chinese homegrown shots at preventing severe illness. China, engulfed in covid chaos, braces for Lunar New Year case spike 2023-01-11T05:00:00Z Hillel has reviewed four other papers for the journal, including one on messenger RNA. Kid-edited journal pushes scientists for clear writing on complex topics 2023-01-07T05:00:00Z Domestic vaccines have proven less effective against serious infection than Western-made messenger RNA versions. China’s COVID-19 surge might spawn a new coronavirus mutant 2022-12-25T05:00:00Z To date, China has declined to authorize Western-made messenger RNA vaccines, which have proven to be more effective than its locally made shots. WHO “very concerned” about reports of severe COVID in China 2022-12-21T05:00:00Z But those shots, which use older technology, have lower efficacy rates than messenger RNA vaccines and offer weaker protection against new variants, experts say. New models predict at least 1 million deaths in China amid covid surge 2022-12-18T05:00:00Z In 2021, it established a hub in South Africa for transferring messenger RNA vaccine technology to companies in low- and middle-income countries. The global plan for COVID-19 vaccine fairness fell short. Will next time be different? 2022-12-12T05:00:00Z President Xi Jinping and his advisers have so far shunned the messenger RNA vaccines developed in the West. How China’s vaccine strategy stoked its looming ‘zero covid’ crisis 2022-12-01T05:00:00Z China’s vaccines rely on an older technology producing fewer antibodies than messenger RNA vaccines. China’s COVID-19 surge might spawn a new coronavirus mutant 2022-12-25T05:00:00Z The other thing I am really proud of is the creation of the WHO mRNA vaccine technology hub, a facility based in Cape Town that aims to provide Africa with messenger RNA vaccines. WHO’s departing chief scientist regrets errors in debate over whether SARS-CoV-2 spreads through air 2022-11-22T05:00:00Z The term "mRNA" is short for "messenger RNA," a specific type of RNA that transmits information from genetic codes in the nucleus to the cytoplasm where proteins are manufactured. Experts taken aback by Florida surgeon general advising against COVID vaccines for young men 2022-10-13T04:00:00Z RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. NOT REAL NEWS: A look at what didn’t happen this week 2022-10-07T04:00:00Z To deliver the gene editor in vivo, the company wrapped that guide RNA plus a messenger RNA encoding the enzyme in a lipid nanoparticle. CRISPR infusion eliminates swelling in those with rare inflammatory disease 2022-09-16T04:00:00Z Unlike current Chagas disease drugs, the compound thwarts a step—the fine-tuning of newly made messenger RNA molecules—necessary for the parasite to synthesize proteins. Possible new treatment for neglected tropical disease 2022-09-06T04:00:00Z Moderna, which has made billions of dollars from a COVID-19 vaccine based on messenger RNA technology, last week accused its main rival of infringing the company’s patents for a similar mRNA shot. News at a glance: High seas biodiversity, Japan’s nuclear power, and banning gasoline cars 2022-08-31T04:00:00Z If a cell requires a certain protein to be synthesized, the gene for this product is turned “on” and the messenger RNA is synthesized in the nucleus. Biology for AP Courses 2022-06-09T00:00:00Z “The messenger RNA from the vaccine does not form a triple helix, and it certainly doesn’t intercalate with the DNA to form a triple helix in any way,” Kuritzkes said. NOT REAL NEWS: A look at what didn’t happen this week 2022-10-07T04:00:00Z Like the existing Moderna and Pfizer-BioNTech vaccines, their vaccine encodes these conserved proteins in messenger RNA and relies on the body to turn that code back into protein. Why efforts to make better, more universal coronavirus vaccines are struggling 2022-07-27T04:00:00Z RNA is closely related to DNA, and one type, called messenger RNA, sends instructions to the cell. NOT REAL NEWS: A look at what didn’t happen this week 2022-07-22T04:00:00Z There are three main types of RNA involved in protein synthesis: messenger RNA, ribosomal RNA, and transfer RNA. Miller & Levine Biology 2018-01-01T00:00:00Z Ribosomes are able to read the genetic information inscribed on a strand of messenger RNA and use this information to string amino acids together into a protein. Biology for AP Courses 2022-06-09T00:00:00Z Some people are allergic to an ingredient in messenger RNA vaccines or simply prefer the more traditional technology at the core of Novavax’s shot, which is the United States’ first protein-based vaccine. FDA authorizes Novavax coronavirus vaccine, adding to pandemic arsenal 2022-07-13T04:00:00Z A molecule of messenger RNA that is complementary to a specific gene is synthesized in a process similar to DNA replication. Anatomy and Physiology 2013-06-19T00:00:00Z The company hopes that its protein-based shot, a vaccine technology that has been widely used for decades, will appeal to Americans who declined to be vaccinated with shots using messenger RNA technology. The U.S. government will buy 3.2 million doses of Novavax’s Covid vaccine. 2022-07-11T04:00:00Z Both CureVac and BioNTech have worked to develop the messenger RNA technology employed in their respective vaccines and potentially for other uses. Germany’s CureVac files suit against vaccine rival BioNTech 2022-07-05T04:00:00Z As we studied in previous chapters, processing messenger RNA involves the removal of introns that do not code for protein. Biology for AP Courses 2022-06-09T00:00:00Z Novavax hopes its product will attract U.S. recipients skeptical of vaccines that employ messenger RNA and booster seekers who favor its proven method, which has led to licensed vaccines for other diseases, such as shingles. News at a glance: African swine fever vaccine, low-dose radiation, and bees as ‘fish’ 2022-06-08T04:00:00Z Transcription of the gene creates a messenger RNA that is translated into the desired protein within the cytoplasm. Anatomy and Physiology 2013-06-19T00:00:00Z Many experts are eager to add another vaccine to the toolbox, particularly because the Johnson & Johnson shot is now recommended only for people who cannot or will not take messenger RNA vaccines. FDA advisers recommend authorizing Novavax coronavirus vaccine 2022-06-07T04:00:00Z Last year, China’s top infectious diseases official acknowledged that the country’s homegrown vaccines offered low protection against COVID-19 and that mixing them with booster doses of the novel messenger RNA vaccines might be needed. WHO clears China’s CanSino COVID vaccine for emergency use 2022-05-19T04:00:00Z This mature messenger RNA then leaves the nucleus and enters the cytoplasm. Biology for AP Courses 2022-06-09T00:00:00Z The WHO said its expert group had assessed the limited data from seven studies for second booster doses of messenger RNA vaccines, saying there wasn’t enough information proving their effectiveness in younger, healthy people. WHO: 2nd COVID booster for most vulnerable offers benefits 2022-05-17T04:00:00Z Two of those shots prompt a recipient’s own cells to manufacture a key piece of the coronavirus by following instructions encoded in messenger RNA, or mRNA for short. With old-school technology, can Novavax win over COVID vaccine skeptics? 2022-05-16T04:00:00Z The vaccine was somewhat less effective in its clinical trial than the messenger RNA vaccines authorized in 2020, and instantly became the butt of jokes and memes portraying it as a lesser vaccine. FDA sharply limits use of Johnson & Johnson shot due to rare blood clots 2022-05-05T04:00:00Z His team was particularly interested in a type that shifts how a cell’s proteinmaking machinery reads a gene’s messenger RNA. Surprising strategy would fight mutant cancer cells by making more mutations 2022-04-19T04:00:00Z The team found that 4 weeks after their fourth shot of the messenger RNA vaccine, recipients were half as likely to be infected as people who had received only three shots. News at a glance: Second boosters, climate protests, and an elusive woodpecker 2022-04-13T04:00:00Z The messenger RNA boosters will be available to people regardless of which brand of coronavirus vaccine they initially received, including Johnson & Johnson recipients. Older adults can get second coronavirus booster to strengthen waning protection 2022-03-29T04:00:00Z It shows that three doses of a messenger RNA vaccine perform the best, while a Johnson & Johnson vaccine followed by a messenger RNA booster shot is next best. CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z People who could still consider the shot include those who have an anaphylactic reaction to messenger RNA vaccines, or people who would otherwise not be vaccinated. FDA sharply limits use of Johnson & Johnson shot due to rare blood clots 2022-05-05T04:00:00Z Hipra is intended to be a booster shot in people who have been fully vaccinated with a messenger RNA vaccine or a vector-based vaccine, like the ones made by AstraZeneca and Johnson & Johnson. EU regulator starts reviewing Spanish COVID vaccine booster 2022-03-29T04:00:00Z Undoubtedly the rapid development of vaccines and therapeutics, including innovative messenger RNA technologies, was the greatest technological success in responding to the pandemic. COVID Pushed Global Health Institutions to Their Limits 2022-03-26T04:00:00Z There were no cases of myocarditis or pericarditis, heart inflammation that rarely occurs after messenger RNA vaccination. Moderna says its coronavirus vaccine for young children is safe, but efficacy is a more complicated picture 2022-03-23T04:00:00Z In December, however, the agency updated its guidance to recommend people get the messenger RNA vaccines over Johnson & Johnson because of concerns about an extremely rare but potentially fatal blood clot issue. CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z In October, Senegal and Rwanda signed an agreement with BioNTech for the construction of its first start-to-finish factories to make messenger RNA vaccines in Africa. Moderna signs with Kenya for first mRNA facility in Africa 2022-03-07T05:00:00Z Moderna has pledged not to enforce patents on its messenger RNA vaccine until the pandemic ends, although a company spokesperson declined to say this week how it will identify that moment. When is a pandemic ‘over?’ 2022-03-04T05:00:00Z The United States is not expected to share NIH-developed technology that was used by Moderna, the vaccine maker that worked closely with the U.S. government in its messenger RNA vaccine. U.S. to share some coronavirus technologies with World Health Organization 2022-03-03T05:00:00Z The group is helping biopharmaceutical companies to develop and produce new substances such as messenger RNA, targeted cancer treatments known as antibody-drug conjugates and viral vectors for gene therapies. Merck KGaA predicts strong earnings growth on lab demand 2022-03-03T05:00:00Z Protection against hospitalization, meanwhile, was significantly higher with three doses of the messenger RNA vaccines, which offered 90 percent effectiveness. CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z In just 17 years, messenger RNA therapies have gone from proof of concept to global salvation. Messenger RNA Therapies Are Finally Fulfilling Their Promise 2022-03-02T05:00:00Z The particles are used to protect and deliver messenger RNA as it travels through the body. Moderna faces new lawsuit over lucrative coronavirus vaccine 2022-02-28T05:00:00Z The shot being copied is a messenger RNA vaccine made by US firm Moderna. Covid: South Africa makes its own version of Moderna vaccine 2022-02-04T05:00:00Z The scientists named the molecule messenger RNA, or mRNA. Halting progress and happy accidents: How mRNA vaccines were made 2022-01-15T05:00:00Z “The messenger RNA vaccines seem to be providing more protection. … What I’d like to see is a very simple recommendation: that everyone get three doses, and they should be messenger RNA vaccines.” CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z Another from Moderna contains messenger RNA that instructs cells to make four different EBV proteins. Two decades of soldiers’ medical records implicate common virus in multiple sclerosis 2022-01-12T05:00:00Z Recent advances are promising: In November 2021, a messenger RNA vaccine that targets ticks themselves proved its worth in early animal trials. Lyme-carrying ticks live longer—and could spread farther—thanks to warmer winters 2022-01-06T05:00:00Z Government scientists worked with Moderna in January 2020 to rapidly develop the spike protein technology key to the company’s messenger RNA vaccine. Moderna halts patent fight over coronavirus vaccine with federal government 2021-12-17T05:00:00Z The vaccines were developed at astonishing speed, and their efficacy in large-scale clinical trials—95% protection from symptomatic illness for the messenger RNA vaccines—surpassed most scientists’ dreams. Missed shots: Science revisits its 2020 Breakthrough of the Year 2021-12-15T05:00:00Z Although the Johnson & Johnson vaccine provides a lower level of initial protection than the messenger RNA vaccines, the company has pointed to evidence that its vaccine’s protection may not erode as quickly. CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z Fauci reviewed a slew of data from the past week showing that antibodies spawned by two doses of messenger RNA vaccines — the Pfizer-BioNTech and Moderna shots — lose their potency against the omicron variant. Fauci says omicron-specific vaccine is not yet needed because booster shots will protect 2021-12-15T05:00:00Z And based on the first cases, scientists in the United Kingdom have estimated that protection from symptomatic illness is much lower in people who have received two doses of the AstraZeneca or messenger RNA vaccines. Scientists see a ‘really, really tough winter’ with Omicron 2021-12-13T05:00:00Z Little is known on how viral vector vaccines developed by companies including AstraZeneca Plc and Johnson & Johnson and inactivated shots made by the Chinese companies react to the new strain, compared to messenger RNA doses. World rushes to boost against omicron, but questions remain 2021-12-10T05:00:00Z China, whose shots are less effective than the messenger RNA shots used in the West, marked the astonishing milestone of having 1 billion people fully vaccinated in September. Omicron raises vaccine questions a year after first Pfizer shot 2021-12-07T05:00:00Z But public messaging became muddled, he said, in part because early studies showed the messenger RNA vaccines provided protection against infection, raising “false expectations.” CDC: If you got J&J’s vaccine and booster, consider an mRNA shot now 2022-03-29T04:00:00Z If they decide a revised shot is necessary — far from certain at this point — the process will take about three months for the messenger RNA shots. How scary is omicron? Scientists are racing to find answers. 2021-12-04T05:00:00Z “Important discoveries stimulated by COVID-19 may also help us make progress against HIV/AIDS,” he said, singling out messenger RNA vaccines and the pool of substances that are effective in vaccines. Fauci says COVID diverted resources from fighting AIDS 2021-11-30T05:00:00Z Earlier this year, the dictionary expanded its definition of “vaccine,” updating it to include the role of messenger RNA technology in the development of shots. ‘Vaccine’ is Merriam-Webster’s word of the year 2021-11-29T05:00:00Z Instead of 10 micrograms of messenger RNA, the 14 children received about 20 micrograms, according to Sutter Health. At a Northern California clinic, 14 children get double the correct dose of the COVID-19 vaccine 2021-11-17T05:00:00Z They also do not rely on the complicated messenger RNA technology that powers the Pfizer-BioNTech shot. Biden administration to buy Pfizer antiviral pills for 10 million people, hoping to transform pandemic 2021-11-16T05:00:00Z A hub set up by the World Health Organization in South Africa intended to share messenger RNA vaccine recipes and technologies has not enticed a single pharmaceutical to join. Pfizer agrees to let other companies make its COVID-19 pill 2021-11-16T05:00:00Z The messenger RNA vaccines, meanwhile, have been associated with an elevated risk of a condition known as myocarditis, or inflammation of the heart muscle. Elevated risk of clots in J&J vaccine recipients, says Mayo Clinic study 2021-11-01T04:00:00Z In a procedure similar to that used to vaccinate adults with the messenger RNA jab in the United States, kids received two doses, three weeks apart. How COVID Vaccines for Young Kids Could Change the Pandemic 2021-10-29T04:00:00Z A hub set up by WHO in South Africa intended to share messenger RNA vaccine recipes and technologies has not enticed a single pharmaceutical to join. Merck agrees to let other drug makers make its COVID pill 2021-10-27T04:00:00Z Rathore also stressed that the messenger RNA technology that went into the coronavirus vaccine is not “experimental,” and that tens of thousands of people participated in trials. Its funding threatened, Miami private school scraps policy to send home vaccinated students 2021-10-26T04:00:00Z Moderna’s vaccine uses messenger RNA technology that teaches the body to detect and combat the virus. Moderna agrees to provide 110M doses of COVID-19 vaccine to Africa 2021-10-26T04:00:00Z Zoltan Kis, an expert in messenger RNA vaccines at Britain’s University of Sheffield, said reproducing Moderna’s vaccine is “doable” but the task would be far easier if the company shared its expertise. African effort to replicate mRNA vaccine targets disparities 2021-10-23T04:00:00Z At first, she saw an error message that said she was not eligible to get the messenger RNA vaccine, seven months after her Johnson & Johnson shot. Recipients of Johnson & Johnson shot rush to get boosters 2021-10-23T04:00:00Z Both versions use messenger RNA, a type of technology that uses genetic instructions to teach the body to detect and fight the virus. U.S. surgeon general: Fine for Pfizer, Moderna recipients to stick to the same brand for booster 2021-10-22T04:00:00Z If health-care providers have the freedom to recommend any booster, they could recommend a messenger RNA dose as a second shot to people who may be at increased risk for an adverse event. FDA to allow ‘mix-and-match’ approach on coronavirus booster vaccines 2021-10-18T04:00:00Z A: Both the Pfizer and the Moderna vaccines are considered “messenger RNA” shots, which means they teach the body to produce a protein that mimics the coronavirus, triggering an immune response. FAQ: What you need to know about COVID-19 boosters 2021-10-18T04:00:00Z But certain procedures are tricky, such as sealing the fragile messenger RNA in lipid nanoparticles, he said. African effort to replicate mRNA vaccine targets disparities 2021-10-23T04:00:00Z The Pfizer and Moderna vaccines are made with a piece of genetic code called messenger RNA that tells the body to make harmless copies of the spike protein so it’s trained to recognize the virus. Why COVID boosters weren’t tweaked to better match variants 2021-10-18T04:00:00Z The data will leave the FDA’s advisory committee with a bigger question: What is the role of a booster of Johnson & Johnson’s vaccine in a country with enough supply of messenger RNA vaccines? Johnson & Johnson recipients may benefit from a booster, but perhaps a different shot, new data suggests 2021-10-13T04:00:00Z That information could be of particular interest to recipients of the Johnson & Johnson vaccine, which, in its initial trial, was somewhat less efficacious than the messenger RNA vaccines made by Pfizer-BioNTech and Moderna. FDA review of Johnson & Johnson booster finds potential benefit in second dose, with limited data 2021-10-13T04:00:00Z Afeyan said the company analyzed whether it would be better to share the messenger RNA technology and determined that it could expand production and deliver billions of additional doses in 2022. Moderna has no plans to share its COVID-19 vaccine recipe 2021-10-11T04:00:00Z Since 30 July, Israel has given a third shot of messenger RNA vaccine to more than 3 million people, including a majority of those 40 and older. Israel’s struggles to contain COVID-19 may be a warning for other nations 2021-09-21T04:00:00Z What I started here at BioNTech, injecting messenger RNA coding for cytokines..., the human trial had already been going on for years. An mRNA Pioneer Discusses How Her Work Led to the COVID Vaccines 2021-09-15T04:00:00Z Johnson & Johnson’s initial advantage was largely logistical — the potential for a speedy vaccination campaign that could help end the pandemic, even though a single shot offered slightly less individual protection than the messenger RNA vaccines. Johnson & Johnson recipients may benefit from a booster, but perhaps a different shot, new data suggests 2021-10-13T04:00:00Z The FDA’s reviews of booster doses of messenger RNA vaccines have not taken a position on whether boosters were needed. FDA review of Johnson & Johnson booster finds potential benefit in second dose, with limited data 2021-10-13T04:00:00Z The Pfizer and Moderna vaccines deliver a synthetic form of messenger RNA into the body, but that material is short-lived and doesn’t affect a body’s genetic material. Florida gov defends the right to choose whether to vaccinate 2021-09-14T04:00:00Z One award went to the biochemists who discovered how to smuggle genetic material called messenger RNA into cells, leading to the development of a new class of vaccine. COVID Advances Win $3-million Breakthrough Prizes 2021-09-09T04:00:00Z Those shots use molecules called messenger RNA to trigger an immune response, while the Johnson & Johnson vaccine uses a harmless virus called an adenovirus to achieve the same result. People who got Johnson & Johnson’s coronavirus shot feel left behind in push for boosters 2021-09-08T04:00:00Z It’s not yet clear what boosters will be given, or when, to those who received the Johnson & Johnson one-dose vaccine, which relies on different technology than the messenger RNA vaccines of Pfizer and Moderna. US reaches 75% of adults with at least 1 vaccine dose 2021-09-07T04:00:00Z For Professor Kariko, there was a long period when it seemed that her research on messenger RNA would never get funding. When Chance Encounters at the Water Cooler Are Most Useful 2021-09-03T04:00:00Z And, at some point in the future, you may be able to get a messenger RNA coronavirus vaccine combined with a flu vaccine. Your coronavirus questions, answered: Flu vaccine 2021-08-20T04:00:00Z It manufactures one of the leading options for vaccination in the U.S., a two-dose regimen with a messenger RNA platform that teaches the body how to attack the coronavirus. Moderna mandates COVID-19 vaccination by Oct. 1 2021-08-20T04:00:00Z But many of the doses set to be produced — and shared so far — are not messenger RNA vaccines, which have been found to produce greater levels of protection. ‘Act now’ on global vaccines to stop more dangerous variants, experts warn Biden 2021-08-10T04:00:00Z The agency is already reviewing the submission for a rival messenger RNA vaccine from Pfizer and BioNTech, and is under growing pressure to complete the process quickly. Moderna touts its COVID vaccine's endurance and earnings that beat expectations 2021-08-05T04:00:00Z Regulatory rigor is especially important for messenger RNA vaccines, which use an entirely new technology, he adds. When will COVID-19 vaccines be fully approved—and does it matter if they are? 2021-07-21T04:00:00Z Drugmakers working on a new type of vaccine likely would not be able to rely on the correlates based on Moderna’s messenger RNA shot, they say. Global quest underway to speed COVID-19 vaccine trials 2021-07-20T04:00:00Z The first two authorized vaccines in the United States — shots from Pfizer and Moderna that use a technology called messenger RNA, known commonly as mRNA — are designed as a two-shot program. New study on delta variant reveals importance of receiving both vaccine shots 2021-07-08T04:00:00Z The United States also is moving to distribute 500 million doses of messenger RNA vaccine that the administration purchased from Pfizer and plans to share with nearly 100 low- and middle-income nations. ‘Act now’ on global vaccines to stop more dangerous variants, experts warn Biden 2021-08-10T04:00:00Z Research published last week in the journal Nature found that memory B cells produced in response to the messenger RNA vaccines are stored in the body and increase over time, building stronger immunity. Coronavirus questions answered: For the vaccinated, would exposure to covid-19 act as booster and strengthen their immunity? 2021-07-01T04:00:00Z They argued there were no comparable clinical trials of other messenger RNA vaccines, because those vaccines were tested before variants emerged. CureVac, the latest experimental coronavirus vaccine, proves just 48 percent effective overall, a disappointing result 2021-06-30T04:00:00Z The company, whose vaccine uses messenger RNA technology and requires two doses, submitted the data to the bioRxiv preprint server ahead of peer review. Moderna says vaccine works against delta variant, as WHO warns of global spread 2021-06-30T04:00:00Z However, the COVID-19 mRNA vaccine injects a snippet of messenger RNA, which enters the patient and causes their cells to manufacture a small piece of the coronavirus called the spike protein. Scientists hope mRNA vaccine technology could be used to cure cancer and HIV 2021-06-27T04:00:00Z “It’s too early to say unmodified, natural messenger RNA is not an option.” CureVac COVID Vaccine Let-down Spotlights mRNA Design Challenges 2021-06-22T04:00:00Z When operators checked a vat at the end of the production run, most of the key ingredient — the fat molecule encasing the messenger RNA — was missing. Inside Pfizer’s race to produce the world’s biggest supply of covid vaccine 2021-06-16T04:00:00Z However, a separate study published in May in The New England Journal of Medicine showed that both the messenger RNA vaccines, Pfizer and Moderna, are effective against the variant based on data from Qatar. A vaccinated person's guide to the most concerning COVID-19 strains 2021-06-12T04:00:00Z Its messenger RNA technology uses a snippet of genetic code that teaches the body to create imposters of the coronavirus’ spike protein, so the body knows how to fight the real thing. WH says Biden will prod G-7 nations to donate COVID-19 vaccines 2021-06-10T04:00:00Z Instead of using the germ itself to make a vaccine, they use messenger RNA and add the genetic code for the germ. Science chief wants next pandemic vaccine ready in 100 days 2021-06-02T04:00:00Z He said his experience with messenger RNA vaccines tested in monkeys against HIV and Zika found that while antibodies do drift downward, they then plateau and remain stable for nearly a year. Scientists are figuring out if we will need another coronavirus shot — and which one 2021-05-27T04:00:00Z Researchers speculate that many Indians would rush to get the messenger RNA vaccines currently only available abroad. Why is the world’s largest COVID-19 vaccine campaign faltering? 2021-05-19T04:00:00Z The active ingredient in the Pfizer-BioNTech shot is messenger RNA, or mRNA, which contains the instructions for human cells to construct a harmless piece of the coronavirus called the spike protein. EU agrees potential 1.8 billion-dose purchase of Pfizer jab 2021-05-08T04:00:00Z At destinations in Germany and in Massachusetts, the DNA is transformed into messenger RNA, “the active ingredient of the Pfizer-BioNTech vaccine.” Coronavirus News Roundup, May 1–May 7 2021-05-07T04:00:00Z Many of them can’t afford the messenger RNA vaccines produced by Pfizer and Moderna, which are also more difficult to store and distribute because they need to be kept at a very low temperature. What’s the future of vaccines linked to rare clotting disorders? Science breaks down the latest 2021-05-03T04:00:00Z Different vaccines use different vehicles to deliver the instructions — for Moderna and Pfizer, messenger RNA, or mRNA; for Johnson & Johnson, an adenovirus genetically modified to be inactive and harmless — but the instructions are similar. No, Other People’s Covid Vaccines Can’t Disrupt Your Menstrual Cycle 2021-04-29T04:00:00Z The vaccines produced by Pfizer-BioNTech and Moderna are based on messenger RNA technology, instead, and are not suspected to cause any unusual clotting. European regulator says J&J coronavirus vaccine needs rare blood clot warning but that benefits outweigh risks 2021-04-20T04:00:00Z Discussions with a staff pharmacist helped allay her concerns about messenger RNA technology used in the Pfizer and Moderna vaccines and provided the final nudge she needed to get to “yes.” Why some health care workers in Washington state were reluctant to get COVID shots 2021-04-19T04:00:00Z The instructions for making the spike protein are encoded in messenger RNA and protected by a tiny ball of fat. What's different about Johnson & Johnson's vaccine that might explain its blood clot risk? 2021-04-15T04:00:00Z Cases of unusual clotting with low platelets have not been seen in recipients of the messenger RNA–based vaccines made by Pfizer or Moderna. Concerns over rare clotting disorders halt use of Johnson & Johnson’s COVID-19 vaccine 2021-04-13T04:00:00Z “She was, in a positive sense, kind of obsessed with the concept of messenger RNA,” he said. Kati Kariko Helped Shield the World From the Coronavirus 2021-04-08T04:00:00Z The vaccines that require two shots are the two from Pfizer and Moderna, which are both approved in the United States and are both made using messenger RNA, or mRNA. Inflammation? Fever? What to expect after your second COVID-19 vaccine shot 2021-04-05T04:00:00Z The active ingredient in the shot is messenger RNA, or mRNA, which contains the instructions for human cells to construct a harmless piece of the coronavirus called the spike protein. Amid AstraZeneca setback, Germany banks on homegrown vaccine 2021-03-31T04:00:00Z Concerns about rare but severe allergic reactions were sparked by reports that two health-care workers in Britain had such reactions after being vaccinated with messenger RNA vaccines. Your questions about coronavirus vaccines, answered Pfizer’s uses the same messenger RNA technology, and all of the vaccines rely on the same general approach of targeting the spike protein the virus uses to attach to and infect human cells. New study of students at UW, other colleges, will answer a key question about coronavirus transmission 2021-03-26T04:00:00Z Unlike the messenger RNA vaccines from Pfizer and Moderna, it uses an older approach similar to that of the shot from Johnson & Johnson. AstraZeneca’s Covid-19 Vaccine Is Found to Be 79% Effective in U.S. Study 2021-03-22T04:00:00Z Both the Pfizer and Moderna vaccines are based on novel messenger RNA technology that holds potential for other vaccines and drugs against an array of diseases. Drug companies defend vaccine monopolies in face of global outcry 2021-03-20T04:00:00Z German leaders argued for a heftier bet on vaccines from Pfizer-BioNTech and CureVac, but they were based on unproven messenger RNA technology and were more expensive. Where Europe Went Wrong in Its Vaccine Rollout, and Why 2021-03-20T04:00:00Z The vaccine made by BioNTech-Pfizer and U.S. rival Moderna uses messenger RNA, or mRNA, to carry instructions into the human body for making proteins that prime it to attack a specific virus. Scientist behind coronavirus shot says next target is cancer 2021-03-19T04:00:00Z The mRNA vaccines use a new technology to transmit the instructions by a bit of genetic material — messenger RNA — encased in a lipid, or fat. Opinion | All of the coronavirus vaccines can save lives. Take whichever you can get. 2021-03-11T05:00:00Z Goepfert said there were health-care workers in the trial who received the Johnson & Johnson vaccine but then became eligible for an authorized vaccine midway through and received one of the messenger RNA vaccines. FDA authorizes Johnson & Johnson’s single-shot coronavirus vaccine, adding to the nation’s arsenal against the pandemic 2021-02-27T05:00:00Z Both vaccines are based on messenger RNA coding for the coronavirus spike protein, which prompts production of protective antibodies. As trials ramp up, doctors stress need to vaccinate kids against COVID-19 2021-02-23T05:00:00Z One bright spot is that the Pfizer-BioNTech and Moderna vaccines, which late last year were found to be about 95 percent effective against the prevailing strain, both use genetic material called messenger RNA. Biden administration, vaccine makers scramble to outflank coronavirus variants 2021-02-19T05:00:00Z The Pfizer and Moderna vaccines are made with a piece of genetic code called messenger RNA that tells the body how to make some harmless copies of the spike protein that train immune cells. COVID-19 shots might be tweaked if variants get worse 2021-02-15T05:00:00Z German company BioNTech created a genetic molecule called messenger RNA that encoded the spike protein. Could a single vaccine work against all coronaviruses? 2021-02-09T05:00:00Z Because messenger RNA does not enter the cell nucleus, it does not affect DNA. Four steps to building vaccine trust in marginalized communities 2021-02-09T05:00:00Z Macron says the EU hadn’t anticipated “such rapid success” of the messenger RNA vaccines made by Pfizer and Moderna, which is mostly produced in the United States. The Latest: China gives broader approval for Sinovac vaccine 2021-02-06T05:00:00Z The company was the first to approach the Indian regulator in December for its messenger RNA vaccine that it has developed with Germany’s BioNTech. The Latest: Israel to begin easing lockdown on Sunday 2021-02-05T05:00:00Z The technology is based off messenger RNA, a molecule that carries genetic code; the two COVID-19 vaccines authorized for emergency use in the U.S. rely on it. How COVID-19 vaccines may lead to new shots for other deadly viruses 2021-01-29T05:00:00Z Unlike the messenger RNA vaccines made by Pfizer-BioNTech and Moderna, Johnson & Johnson uses an adenovirus, which normally causes the common cold. Johnson & Johnson’s Vaccine Offers Strong Protection but Fuels Concern About Variants 2021-01-29T05:00:00Z By contrast, the Pfizer-BioNTech and Moderna vaccines are based on messenger RNA technology that was first authorized for use in humans in December. The U.S. may soon have a third vaccine. Here's how it works 2021-01-29T05:00:00Z Investments in messenger RNA technology laid the groundwork for the speedy development of the two vaccines approved in the U.S. Bill Gates: We must prepare for the next pandemic like we prepare for war 2021-01-27T05:00:00Z Both use genetic material called messenger RNA that acts much like software, instructing the body’s cells how to build the spike protein found on the outside of the coronavirus. New coronavirus variants accelerate race to make sure vaccines keep up 2021-01-25T05:00:00Z The two vaccines in use so far were actually developed through a new technology that uses messenger RNA. Most Americans say the coronavirus pandemic is not controlled, Post-ABC poll finds 2021-01-18T05:00:00Z Even so, she said, the shots should be “highly suggested” but not mandatory — especially because those available rely on messenger RNA, a technology that hasn’t been used in vaccines before. Some workers don’t want a COVID-19 vaccine. Can their bosses make them get it anyway? 2021-01-15T05:00:00Z “The adenovirus is just like messenger RNA, but it uses a different vector.” The U.S. may soon have a third vaccine. Here's how it works 2021-01-29T05:00:00Z And in vaccines, two of the ones designed to protect people against Covid-19 are based on a molecule called messenger RNA, or mRNA. V.R. Is Not a Hit. That’s OK. 2021-01-05T05:00:00Z CLAIM: COVID-19 vaccines that rely on messenger RNA technology will teach the body to attack itself, leading to autoimmune disease. NOT REAL NEWS: A look at what didn’t happen this week 2021-01-08T05:00:00Z The vaccines do not contain the coronavirus itself, but rather synthetic messenger RNA that instructs cells to manufacture a protein that looks like the spike protein on the coronavirus. Allergic reactions to the coronavirus vaccine are rare and outweighed by the benefit of protection, CDC finds 2021-01-06T05:00:00Z But he shrugged off safety concerns, arguing that unlike the messenger RNA vaccines produced by Pfizer/BioNTech and Moderna, Bharat Biotech’s approach–an inactivated whole virus–has a long history of safe use. Scientists criticize ‘rushed’ approval of Indian COVID-19 vaccine without efficacy data 2021-01-05T05:00:00Z The Pfizer-BioNTech and Moderna shots are the first vaccines using messenger RNA technology approved for human use by the Food and Drug Administration. Your questions about coronavirus vaccines, answered While Pfizer’s vaccine relies on a molecule called messenger RNA, or mRNA, packaged into greasy bubbles, AstraZeneca’s shots are designed around a virus shell that delivers DNA, a cousin of mRNA. Britain opts for mix-and-match vaccinations, confounding experts 2021-01-01T05:00:00Z THE FACTS: There is no evidence that the so-called messenger RNA, or mRNA, vaccines made by Pfizer-BioNTech and Moderna cause autoimmune disease. NOT REAL NEWS: A look at what didn’t happen this week 2021-01-08T05:00:00Z Pfizer’s recipe is designed around a molecule called messenger RNA, or mRNA, which, once injected, enters human cells and instructs them to manufacture a coronavirus protein called spike. Vaccines Take a While to Kick In. Experts Say That Means the Body Is Doing Its Job. 2020-12-31T05:00:00Z Still, the messenger RNA platform used in two newly authorized vaccines is comparatively easy to modify to handle mutant strains, he said. California, Colorado confirm infections with U.K. coronavirus variant 2020-12-30T05:00:00Z Their vaccines, which both rely on messenger RNA coding for a viral surface protein, present another obstacle for many countries: They require transportation at subzero temperatures. ‘It’s crazy.’ Upbeat COVID-19 vaccine news from China and U.K. leave scientists wanting more details 2020-12-30T05:00:00Z That messenger RNA, or mRNA, induces the body to produce some harmless spike protein, enough to prime the immune system to react if it later encounters the real virus. More COVID-19 vaccines in the pipeline as US effort ramps up 2020-12-28T05:00:00Z The Pfizer vaccine is a relatively new type of vaccine that relies on synthetic messenger RNA. Allergic reactions to Pfizer vaccine may have been caused by additive, not mRNA itself 2020-12-24T05:00:00Z Instead they harness a synthesized piece of messenger RNA, fundamentally no different from what is already in our bodies. Vaccines will work against new coronavirus variants spreading through U.K. and South Africa, experts believe 2020-12-24T05:00:00Z What they're doing is using messenger RNA that goes into your body. Public health doctor on pandemic holiday travel: "It sucks, but cancel your plans" 2020-12-21T05:00:00Z The vaccines do not contain the coronavirus itself, but rather synthetic messenger RNA that instructs cells to manufacture a protein that looks like the spike protein of the coronavirus. NIH launching study on rare allergic reactions to coronavirus vaccine 2020-12-21T05:00:00Z Both the Pfizer and Moderna vaccines rely on a new technology: They deliver messenger RNA, or instructions, that cells use to build a protein or piece of a protein that triggers an immune response. Teachers will be near the front of the COVID-19 vaccine line, students in the back. What does this mean for reopening schools? 2020-12-19T05:00:00Z In the vaccine itself, there’s one active ingredient: a molecule called messenger RNA, or mRNA, which contains genetic instructions for a coronavirus protein called spike. No, there are no microchips in coronavirus vaccines. 2020-12-17T05:00:00Z Since 1961, scientists have known about messenger RNA, genetic material that makes life possible, taking instructions inscribed in DNA and delivering them to the protein-making parts of the cell. FDA authorizes a second coronavirus vaccine, a turning point in the pandemic 2020-12-17T05:00:00Z It did not use that messenger RNA approach. Public health doctor on pandemic holiday travel: "It sucks, but cancel your plans" 2020-12-21T05:00:00Z The Germany firm, which focuses on immune therapies and is a pioneer in “messenger RNA,” is sometimes overshadowed by its giant partner in the COVID-19 fight, Pfizer of New York City. Germany’s Angela Merkel thanks husband-wife team at BioNTech 2020-12-18T05:00:00Z Melissa J. Moore, Moderna’s chief scientific officer, explained that a snippet of genetic material, called messenger RNA, is encapsulated in a tiny fat bubble and delivered to the body’s lymph node cells. FDA vows to move 'rapidly’ to authorize second coronavirus vaccine 2020-12-17T05:00:00Z And much of the groundwork for the shots was laid over the past decade, including through research on messenger RNA, or mRNA, used in the vaccines developed by both Pfizer and Moderna. Trump stays on sidelines as vaccine injections begin 2020-12-18T05:00:00Z That code — known as messenger RNA, or mRNA — instructs the body to build copies of the spike protein that studs the virus’ surface. How the COVID-19 vaccines from Moderna and Pfizer compare head to head 2020-12-15T05:00:00Z Pfizer and Moderna gambled on a promising but unproved technology that relied on messenger RNA, spurring criticism for taking that approach at a time when a vaccine was desperately needed. How the ‘deep state’ scientists vilified by Trump helped him deliver an unprecedented achievement 2020-12-14T05:00:00Z The Pfizer vaccine, the first to be distributed, is made not with weakened or inactivated whole viruses, but with molecules called messenger RNA. COVID-19 vaccine wasn’t tested in pregnancy, but experts say it’s still worth considering if you’re expecting 2020-12-14T05:00:00Z Moore explained that the vaccine contains the synthetic messenger RNA and a fat bubble. FDA vows to move 'rapidly’ to authorize second coronavirus vaccine 2020-12-17T05:00:00Z The newly authorized vaccine, like the Moderna shot, uses a synthesized scrap of genetic information, called messenger RNA, that is wrapped in a protective fat layer to keep it from disintegrating. Coronavirus vaccines can have side effects. That typically means they’re working. 2020-12-12T05:00:00Z Rather than using a weakened or killed piece of the coronavirus to prompt an immune response, the Pfizer-BioNTech vaccine relies on a piece of the coronavirus’ genetic code called messenger RNA. FDA OKs Pfizer vaccine, opening new front against COVID-19; shots to begin within days 2020-12-11T05:00:00Z The vaccine uses innovative messenger RNA technology to introduce the body to the spike protein on the surface of the coronavirus. FDA reportedly approves Pfizer/BioNTech coronavirus vaccine for emergency use in US 2020-12-11T05:00:00Z Once the vaccine is injected into the body, the genetic payload — called messenger RNA, or mRNA — instructs cells to produce specific coronavirus proteins. Pfizer's COVID-19 vaccine gets nod from scientists, paving way for FDA authorization 2020-12-10T05:00:00Z The vaccine uses messenger RNA technology to introduce the body to the spike protein found on the outside of the coronavirus to provoke an immune response. FDA advisory panel recommends approval of Pfizer Covid vaccine for emergency use 2020-12-10T05:00:00Z Those vaccines—none made in China—use messenger RNA that codes for the surface protein or stitch the gene for it into putatively harmless adenoviral vectors. Great efficacy claimed for another COVID-19 vaccine, this one from China 2020-12-09T05:00:00Z The Pfizer and Moderna vaccines both use a type of technology, based on messenger RNA, that hasn’t been previously used in a medical product? FDA head explains why he'll take the COVID-19 vaccine: "I have 100% confidence" 2020-12-09T05:00:00Z Instead, it uses a bit of messenger RNA, which encourages the body to produce antibodies to repel the spike protein on the surface of the coronavirus. Britain launches the West’s first mass coronavirus vaccination — with a Maggie and a William Shakespeare first in line 2020-12-08T05:00:00Z Vaccines from Pfizer and Moderna, which used messenger RNA, are ahead of the others and are on track for approval by Christmas. Trump praises scientist pivotal to FDA’s approval to build confidence in vaccine 2020-12-08T05:00:00Z Weissman noted that mice injected with messenger RNA would suffer every side effect, from feeling lousy and losing their appetites to dying. A gamble pays off in ‘spectacular success’: How the leading coronavirus vaccines made it to the finish line 2020-12-06T05:00:00Z Yet what is particularly striking is that both are mRNA vaccines, mRNA being short for "synthetic messenger RNA." Why mRNA vaccines like those being made to treat coronavirus are a quantum leap for biotech 2020-12-06T05:00:00Z Two of the leading vaccine candidates are created with messenger RNA, known also as mRNA. NOT REAL NEWS: A look at what didn’t happen this week 2020-12-04T05:00:00Z It deploys not a crippled virus or a bit of virus, as traditional vaccines do, but a snip of messenger RNA, delivered into muscle cells in the body. U.K. authorizes Pfizer coronavirus vaccine as U.S. hospitalizations, daily cases reach record high 2020-12-02T05:00:00Z Both vaccines rely on revolutionary technology that uses messenger RNA, or mRNA, to create protection at the molecular level by injecting a piece of genetic code that primes the body’s defenses. Editorial Roundup: US 2020-12-02T05:00:00Z Founded twelve years ago, BioNTech specializes in harnessing so-called messenger RNA, or mRNA, to train the immune system to attack hostile invaders, from viruses to tumors. Vaccine 1st puts spotlight on German pharma company BioNTech 2020-12-02T05:00:00Z As Dr. Norbert Pardi, a research assistant professor of Medicine at the University of Pennsylvania and an expert on messenger RNA therapeutics, explained to Salon, there are three major type of vaccines. Why mRNA vaccines like those being made to treat coronavirus are a quantum leap for biotech 2020-12-06T05:00:00Z Vaccines that use mRNA, or messenger RNA, work by carrying a genetic message into the body that signals cells to produce the novel coronavirus’s distinctive spike protein, triggering an immune response that creates specific antibodies. Doctors and nurses want more data before championing vaccines to end the pandemic 2020-11-21T05:00:00Z Pfizer and Moderna said this month that their vaccines, which use a technology known as “messenger RNA,” appear to be about 95 percent effective. After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine 2020-11-25T05:00:00Z Moderna, which is also using messenger RNA, is set to request FDA approval soon. Health Secretary Azar: Already briefing Biden team on COVID-19, vaccine coming in ‘just a few weeks’ 2020-11-24T05:00:00Z Earlier this month Pfizer announced promising preliminary results with its vaccine, which like the Moderna vaccine uses genetic material called messenger RNA. Georgia residents, doctor, lawmaker helped in vaccine effort 2020-11-21T05:00:00Z Embryos with the knocked-out genes should develop into fertile adults if injected with messenger RNA, according to a paper the group published last month in Scientific Reports. New genetic tools will deliver improved farmed fish, oysters, and shrimp. Here’s what to expect 2020-11-19T05:00:00Z The idea of creating a vaccine with messenger RNA, or mRNA—the substance that converts DNA into proteins—goes back decades. For Billion-Dollar COVID Vaccines, Basic Government-Funded Science Laid the Groundwork 2020-11-18T05:00:00Z Adding to the difficulty, Pfizer and Moderna are using a technology, involving genetic material known as messenger RNA, that allows scientists to quickly adapt the technique for new pathogens. The Vaccines Will Probably Work. Making Them Fast Will Be the Hard Part. 2020-11-17T05:00:00Z The messenger RNA encodes the blueprint for the hallmark spiky proteins that stud the surface of the coronavirus and, once inside a person’s body, it instructs cells to build replicas of the spike. A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be 2020-11-17T05:00:00Z A: If cleared, these two will be the first vaccines using messenger RNA technology ever approved for human use by the Food and Drug Administration. Q&A: What you need to know about the Moderna and Pfizer coronavirus vaccines 2020-11-17T05:00:00Z Both the Pfizer and Moderna vaccines use a new technology called synthetic messenger RNA to activate the immune system against the virus. Moderna vaccine stability enables distribution in rural America: U.S. official 2020-11-16T05:00:00Z After several years they founded BioNTech as well, looking to use a wider range of technologies, including messenger RNA, to treat cancer. The Husband-and-Wife Team Behind the Leading Vaccine to Solve Covid-19 2020-11-10T05:00:00Z It takes genetic material called messenger RNA and injects it into muscle cells, which treat it like instructions for building a protein — a protein found on the surface of the coronavirus. Pfizer’s Early Data Shows Vaccine Is More Than 90% Effective 2020-11-09T05:00:00Z The scientists then fill a special plastic bag with the purified messenger RNA and freeze it down. A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be 2020-11-17T05:00:00Z Making messenger RNA vaccines does not require time-consuming steps, such as growing ingredients in chicken eggs. Q&A: What you need to know about the Moderna and Pfizer coronavirus vaccines 2020-11-17T05:00:00Z Produced by the biotech company Moderna, the shots directly deliver snippets of coronavirus messenger RNA, which contains instructions for producing the spike protein. Roll up your sleeve to fight COVID-19: 3 new vaccine trials will start soon in the Seattle area 2020-11-09T05:00:00Z Speaking to a roomful of infectious disease experts, he said his company might be able to use its so-called messenger RNA technology to rapidly develop a vaccine in the event of a global pandemic. The Husband-and-Wife Team Behind the Leading Vaccine to Solve Covid-19 2020-11-10T05:00:00Z Those platforms rely on DNA loaded in disabled viruses or on messenger RNA to carry genetic instructions for building the spike protein. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z The messenger RNA is combined with the lipid nanoparticles using a specialized piece of equipment and readied to be put in vials. A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be 2020-11-17T05:00:00Z And with a range of different vaccine technologies being explored - from viral vector vaccines to ones based on messenger RNA - standard evaluation of their true potential “becomes very complex”, she said. Exclusive: New global lab network will compare COVID-19 vaccines head-to-head 2020-10-02T04:00:00Z It contains genetic molecules called messenger RNA that are injected into muscle cells, which treat them like instructions for building a protein. Trump Vaccine Chief Casts Doubt on Coronavirus Vaccine by Election Day 2020-09-03T04:00:00Z The others, based on a messenger RNA model never before used on humans, are under development by Moderna and by Pfizer. Column: Drugmaker AstraZeneca teaches Trump why the virus hunt can't be rushed 2020-09-09T04:00:00Z The biotech company Moderna and Pfizer and research partners are separately testing vaccines based on an immunization model employing messenger RNA that has never been used before. Column: Trump's plot for a pre-election vaccine puts politics before science 2020-09-04T04:00:00Z CureVac’s approach is based on so-called messenger RNA, pieces of genetic code that prompt human cells to produce therapeutic proteins. EU, CureVac in advanced talks for 225 million COVID-19 vaccine doses 2020-08-20T04:00:00Z A protein vaccine could provide strong antibody protection, while another vaccine — perhaps one based on messenger RNA or an adenovirus — could enlist T cells. Scientists Are Optimistic About New Vaccine Studies From Novavax 2020-08-04T04:00:00Z The Moderna vaccine delivers a kind of genetic material called “messenger RNA” into cells. Johnson & Johnson’s Coronavirus Vaccine Protects Monkeys, Study Finds 2020-07-30T04:00:00Z They use genetic material from the coronavirus called messenger RNA, or mRNA. Fauci Optimistic About COVID-19 Vaccines, Though Immunity Unknowns Complicate Development 2020-07-31T04:00:00Z “It’s a historic day for science, as well. This is the first Phase 3 of a messenger RNA medicine in the world.” Two coronavirus vaccines begin the last phase of testing: 30,000-person trials 2020-07-27T04:00:00Z Pfizer and BioNTech are developing a vaccine candidate that uses genetic material from the virus, known as messenger RNA, to stimulate the immune system without making the recipient sick. Pfizer Gets $1.95 Billion to Produce Coronavirus Vaccine by Year’s End 2020-07-22T04:00:00Z To better understand how the condition changes from day to day, Orange and colleagues decided to track fragments of messenger RNA in the blood of five patients with uncontrolled RA. Newly identified cell type may help predict, treat rheumatoid arthritis flares 2020-07-17T04:00:00Z This promising — but unproven — new generation of vaccine technologies is based on deploying a tiny snip of genetic code called messenger RNA to trigger the immune system. Elegant but unproven, RNA experiments leap to the front in coronavirus vaccine race. Will they work? 2020-07-05T04:00:00Z Its speedy response to the covid-19 pandemic was enabled by its vaccine technology based on messenger RNA, which carries genetic codes instructing human cells to produce what is known as a “spike protein” molecule. A coronavirus vaccine rooted in a government partnership is fueling financial rewards for company executives 2020-07-02T04:00:00Z Once packaged, many vaccines need to be kept cold - and some leading contenders made from genetic material such as messenger RNA need to be kept very cold - presenting another challenge that may limit access. Vaccine makers face biggest medical manufacturing feat in history 2020-06-25T04:00:00Z The messenger RNA then prompts the cells to churn out a tiny piece of the virus, causing the immune system to attack the real virus if the person is exposed. Pfizer Gets $1.95 Billion to Produce Coronavirus Vaccine by Year’s End 2020-07-22T04:00:00Z The authors used an RNA molecule called a small hairpin RNA to promote degradation of messenger RNA transcribed from the gene that encodes PTB, Ptbp1. Method to combat Parkinson’s disease by astrocyte-to-neuron conversion 2020-06-23T04:00:00Z They discovered strands of extracellular messenger RNA, or ex-mRNA, that were longer than expected. The biologist on the hunt for extracellular ribosomes 2020-06-16T04:00:00Z The investment gives the German state a foothold in an unproven but promising area of pharmaceutical development known as messenger RNA, in which a vaccine teaches the body’s cells to identify and attack a virus. Federal Reserve opens lending program for small and midsize businesses 2020-06-15T04:00:00Z Moderna’s vaccine uses a genetic material called messenger RNA that codes for the distinctive spike protein that studs the outside of the novel coronavirus. Moderna’s coronavirus vaccine shows encouraging early results 2020-05-18T04:00:00Z Another new approach, mRNA vaccines, works by exploiting messenger RNA — a kind of courier that communicates the genetic instructions for making proteins — to drive an immune response. How Scientists Could Stop the Next Pandemic Before It Starts 2020-04-21T04:00:00Z The NIH’s vaccine candidate, manufactured by Moderna Inc., works similarly, except it uses a type of genetic code called messenger RNA and is injected deeper - into the muscle. Second US study for COVID-19 vaccine uses skin-deep shots 2020-04-08T04:00:00Z The potential vaccine is based on messenger RNA, which directs the body to make a protein found on the coronavirus’s outer shell. Coronavirus latest: Italy death toll overtakes China’s 2020-03-19T04:00:00Z The shot carries a specific stretch of messenger RNA that contains the instructions to build the receptor on the virus’ surface that allows the immune system to target it. First participant in US coronavirus vaccine trial to be given dose 2020-03-16T04:00:00Z The vaccine delivers the messenger RNA to cells, which then follows the genetic instructions to create the virus protein — allowing the body to learn to recognize and neutralize the pathogen. Moderna’s coronavirus vaccine shows encouraging early results 2020-05-18T04:00:00Z At the center of it all is a molecule called messenger RNA, or mRNA. Researchers Rush to Test Coronavirus Vaccine in People 2020-03-12T04:00:00Z Inject a vaccine containing that code, called messenger RNA or mRNA, and people’s cells produce some harmless spike protein. Behind the scenes, scientists prep for COVID-19 vaccine test 2020-03-08T05:00:00Z In both the acute and chronic stages of infection, this gene is transcribed into messenger RNA. One gene to rule them all in a chronic brain infection 2020-03-01T05:00:00Z The NIH team is pursuing a newer and far faster method: Simply use a piece of the virus’ genetic code, called messenger RNA or mRNA, that instructs cells to make a particular protein. Experts scramble, but new virus vaccine may not come in time 2020-02-06T05:00:00Z In 2012, his team at the University of Tübingen in Germany discovered that by linking enzymes to engineered strands of RNA, they could change the sequences of messenger RNA molecules in cells. Step aside CRISPR, RNA editing is taking off 2020-02-03T05:00:00Z Scientists at the company plan to use the genetic information to create synthetic messenger RNA, which carries instructions for cells’ protein-making machinery. Researchers Are Racing to Make a Coronavirus Vaccine. Will It Help? 2020-01-28T05:00:00Z Each patch contains many copies of a nucleic-acid probe that binds to messenger RNA in the tissue sample and carries a sequence called a barcode. Techniques converge to map the developing human heart at single-cell level 2020-01-26T05:00:00Z To fashion any protein, a cell first copies a gene into messenger RNA. New universe of miniproteins is upending cell biology and genetics 2019-10-17T04:00:00Z Each binds to the messenger RNA that encodes the mutated protein. Why rare genetic diseases are a logical focus for RNA therapies 2019-10-15T04:00:00Z And that’s how the most familiar form of RNA, messenger RNA, works. RNA therapies explained 2019-10-15T04:00:00Z Kremer’s dramatic response exemplifies the medical potential of vaccines built on messenger RNA. Unlocking the potential of vaccines built on messenger RNA 2019-10-15T04:00:00Z More-radical production techniques are also approaching approval, such as growing vaccines in plants or delivering them using messenger RNA. Accelerating flu protection 2019-09-17T04:00:00Z When a virus infects a plant cell, it often releases RNA—either in the form of messenger RNA or double-stranded RNA—which travels through the cell, helping the virus replicate. New ‘medicine’ could vaccinate plants against devastating viruses 2019-08-26T04:00:00Z In addition, when bacteria were engineered so that Cas13 targeted a messenger RNA encoded by a circular DNA sequence called a plasmid, bacterial growth was impaired2,6. Bacterial dormancy curbs phage epidemics 2019-05-28T04:00:00Z Monitoring messenger RNA in cells is a way to gather data that provides many biological insights. Pinpointing a spatial address for RNA profiles in tissues 2019-05-02T04:00:00Z So our bodies use a short strand of genetic code, called messenger RNA, to bridge the gap and carry the instructions. 'New class' of medicine reverses disease 2019-04-13T04:00:00Z Brenner also co-discovered messenger RNA — intermediary molecules that convey a cell’s genetic code to the cellular machinery that translates it into a protein. New hominin species, asteroid explosion and Sydney Brenner dies 2019-04-09T04:00:00Z Brenner also co-discovered messenger RNA, contributed to the understanding of the genetic code of DNA and spearheaded medical research in Singapore. Daily briefing: A romp through the history of calculus 2019-04-04T04:00:00Z These intermediary molecules convey a cell’s genetic code, which is written in DNA, to the cellular machinery that translates messenger RNA into a protein. Geneticist Syndey Brenner, who made tiny worm a scientific legend, dies 2019-04-04T04:00:00Z The low levels of messenger RNA produced enter the cytoplasm and undergo a process called reverse transcription to produce DNA. Inhibition of ‘jumping genes’ promotes healthy ageing 2019-02-05T05:00:00Z These findings suggest that the element that enables the cells to grow when nutrients are limited is the intron itself, rather than the messenger RNA or the protein encoded by the gene. Intron RNA sequences help yeast cells to survive starvation 2019-01-15T05:00:00Z They found that the types of messenger RNA that bind to TDP-43 changed markedly as muscle precursors differentiated into muscles. A neurodegenerative-disease protein forms beneficial aggregates in healthy muscle 2018-10-30T04:00:00Z They’re scattered throughout cells and among other things, they help cut messenger RNA into pieces, some of which get pasted back together. Lasker Awards Given for Work in Genetics, Anesthesia and Promoting Women in Science 2018-09-11T04:00:00Z Each ribosome works along a molecule of messenger RNA, reading its copy of the genetic instructions encoded in DNA. Ribosome reader to Royal Society leader: a biologist’s road to the Nobel 2018-09-03T04:00:00Z This approach is used typically to measure the abundance of messenger RNA transcripts for each gene in every cell of a sample. Technique to measure the expression dynamics of each gene in a single cell 2018-08-07T04:00:00Z The genomics revolution was spurred by the development of techniques to measure messenger RNA levels for every gene3,4 and thus to profile gene expression across the genome. Profile of an unknown airway cell 2018-07-31T04:00:00Z The innovative treatment comprises an antisense oligonucleotide — a molecule that binds to messenger RNA to prevent the production of a specific protein. Huntington’s disease 2018-05-29T04:00:00Z Their job is to bind to another molecule called messenger RNA, whose task in turn is to ferry information read from a gene to the cellular factories that create the required protein. How stress echoes down the generations 2018-05-24T04:00:00Z Last year, for instance, two teams independently published methods — called REAP-seq11 and CITE-seq12 — for analysing proteins and messenger RNA simultaneously in single cells. Single-cell approaches to immune profiling 2018-05-21T04:00:00Z Figure 1 | Measuring dynamic changes in gene expression across complex tissues. a, As messenger RNA matures, sections of the immature transcript are removed — a process called splicing. Technique to measure the expression dynamics of each gene in a single cell 2018-08-07T04:00:00Z That effort looked at transcripts of messenger RNA, the family of RNA molecules that conveys information from DNA to build proteins. Flu virus finally sequenced in its native form 2018-04-19T04:00:00Z He mixed ribosomes, the messenger RNA that encodes proteins, cytosol and membranes in vitro. Günter Blobel (1936–2018) 2018-03-22T04:00:00Z Micro-RNA renders messenger RNA inactive, reducing the activity of the gene in question—and it can travel in sperm alongside DNA. How stress echoes down the generations 2018-05-24T04:00:00Z In life, messenger RNA carries the plans of proteins from genes in a cell’s chromosomes to tiny factories, called ribosomes, where those proteins are then made. A new method to find the time of death shows promise 2018-02-27T05:00:00Z Micro-RNAs regulate this process by binding to the messenger RNA, making it inactive. The ramifications of a new type of gene 2018-02-22T05:00:00Z Carroll said both editing systems offer the chance to correct specific disease mutations, either in DNA or messenger RNA. U.S. scientists unveil powerful new tools to fix genetic faults 2017-10-25T04:00:00Z The governing rule of molecular biology — the central dogma — holds that information flows from DNA to messenger RNA to protein. An epigenetics gold rush: new controls for gene expression 2017-02-21T05:00:00Z The test, which is already available outside the country, measures messenger RNA levels of biomarkers associated with an increased probability of aggressive disease. New Diagnostic Tools for Prostate Cancer 2015-12-21T05:00:00Z The reason for this initial resistance is a variation in the messenger RNA sequence that is used as a template for building the androgen-receptor protein itself. Metastasis: Resistance fighters : Nature : Nature Publishing Group 2015-12-14T05:00:00Z German and U.S. firms are leading the way in synthetic messenger RNA, or mRNA technology, a new approach to tackling a range of hard-to-treat diseases. Germany, U.S. in hot pursuit of 'messenger' drug molecules 2015-11-12T05:00:00Z Carroll said both editing systems offer the chance to correct specific disease mutations, either in DNA or messenger RNA. U.S. scientists unveil powerful new tools to fix genetic faults 2017-10-25T04:00:00Z The drug is a manufactured stretch of genetic code that is the mirror-image of the messenger RNA that binds strongly to it to neutralising it. Landmark Huntington's trial starts - BBC News 2015-10-19T04:00:00Z The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes. Molecular biology: Mediating transcription and RNA export : Nature : Nature Publishing Group 2015-10-06T04:00:00Z The team chose a set of these synthetic probes that selectively bind to three messenger RNA molecules associated with primary graft dysfunction. Sensors Save Lung Transplant Patients from Organ Failure 2015-09-01T04:00:00Z Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described7, as well as in genes participating in a broad range of other cellular functions. The octopus genome and the evolution of cephalopod neural and morphological novelties : Nature : Nature Publishing Group 2015-08-11T04:00:00Z “The key for messenger RNA is going to be delivery,” says Joseph Payne, president and chief executive of Arcturus Therapeutics in San Diego, one of many drug developers working on nanoparticle-based delivery of mRNA therapeutics. Business: The billion-dollar biotech 2015-06-02T04:00:00Z The company uses injectable messenger RNA molecules to trigger production of proteins that perform basic bodily functions. Move Over, Elon Musk: CNBC's No. 1 Disruptor This Year Is A Biotech Company, Moderna 2015-05-12T04:00:00Z Transcription culminates in the export of messenger RNA transcripts from the nucleus to the cytoplasm, where they are translated into proteins. Molecular biology: Mediating transcription and RNA export : Nature : Nature Publishing Group 2015-10-06T04:00:00Z That includes things like messenger RNA therapies, and drugs that work to alter the microbiome. Flagship Ventures, After a String of IPOs, Gets $537M To Build More Biotech Startups 2015-03-26T04:00:00Z Broadly speaking, each type of messenger RNA corresponds to a single gene. Genetically modified people 2015-03-12T04:00:00Z These fragments prevent the insect’s ribosome from reading the messenger RNA for the essential protein. Crop Pests Stopped by Plants That Cripple Attackers' RNA 2015-03-02T05:00:00Z But rather than inhibiting antithrombin's activity, the company plans to block its expression by using short strands of RNA to silence the messenger RNA that carries the code for antithrombin—an approach called RNA interference. Time for a ‘Completely Different’ Haemophilia Treatment? 2015-01-12T05:00:00Z But rather than inhibiting antithrombin's activity, the company plans to block its expression by using short strands of RNA to silence the messenger RNA that carries the code for antithrombin — an approach called RNA interference. Thrombosis: Balancing act : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Flagship’s biggest claim to fame is that it created Moderna Therapeutics, a messenger RNA drug developer. Flagship Ventures, After a String of IPOs, Gets $537M To Build More Biotech Startups 2015-03-26T04:00:00Z "Silencer" RNA disrupts the delivery of messenger RNA, preventing the virus from replicating, Hirsch said. Drug for Ebola-Like Virus Shows Promise in Monkeys 2014-08-20T04:00:00Z This time around, Westwood examined the plants’ messenger RNA, or mRNA, the molecule in cells that instructs organisms how to code certain proteins that are key to functioning. Speaking in (Green) Tongues: Scientist Discovers New Plant Language The ‘most wanted’ list of proteins that remain to be imaged includes the massive spliceosome, which helps to organize and edit messenger RNA, and the even larger nuclear-pore complex, which serves as a nucleus’s gatekeeper. Crystallography: Atomic secrets 2014-01-29T18:50:52.346Z Sequencing of messenger RNA, small RNA and BAC ends was supported by grants from the Biomedical Research Council of A*STAR, Singapore. Elephant shark genome provides unique insights into gnathostome evolution 2014-01-08T18:21:42.027Z That bet, especially when it was made during the lean years, represented an unusually daring approach to biotech venture investing since biologists almost universally thought messenger RNA molecules couldn’t be drugs at the time. Flagship Ventures, After a String of IPOs, Gets $537M To Build More Biotech Startups 2015-03-26T04:00:00Z The frequency and size of these bursts affect the magnitude of temporal fluctuations in messenger RNA and protein content within a cell, creating variation or “noise” in gene expression. [Special Issue Review] Genetic Determinants and Cellular Constraints in Noisy Gene Expression 2013-12-05T18:56:36.154Z When the error was corrected, the median levels of detected proteins increased about threefold and the ratio of average protein to messenger RNA increased from 900 to 2,800. Corrigendum: Global quantification of mammalian gene expression control 2013-03-06T18:22:35.980Z Normally a DNA gene copies itself onto messenger RNA, which serves as the cell’s template for making proteins. For Isis CEO, A Victory After 24 Years Of Battle 2013-01-30T11:40:39Z Antisense drugs are small snippets of synthetic DNA or RNA that bind to that messenger RNA in a way that inactivates or destroys it. F.D.A. Approves Genetic Drug to Treat Rare Disease 2013-01-30T02:46:36Z Gene modelling, annotation and alternative splicing analyses were assisted by three messenger RNA data sets: ESTs generated before the genome projects, JGI-generated ESTs and RNA-seq data. Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs 2012-12-05T18:51:06.810Z MicroRNAs are regulatory RNAs that affect the stability and efficiency of the translation of messenger RNA, the intermediate between genes and proteins. Perspective: Not just for women 2012-05-30T17:51:20.620Z That allows him to find out whether genetic variants correlate with changes in messenger RNA. Functional genomics: The changes that count 2012-02-08T18:51:01.997Z These teeny-tiny snippets of RNA serve regulatory roles in our cells, attaching to bits of messenger RNA and causing changes in expression of different proteins. The Very Real Scaremongering of Ari Levaux 2012-01-12T17:15:03.063Z Another possibility, Traynor says, is that the repeated nucleotides cause a toxic buildup of messenger RNA, a key player in the cellular machinery for reading out DNA to make protein. Same Mutation Causes Lou Gehrig's Disease and Dementia 2011-09-21T17:20:50Z While normal genes express their will by sending signals of messenger RNA, the damaged pseudogenes either are mute or speak in gibberish. Cancer?s Secrets Come Into Sharper Focus 2011-08-15T17:02:05Z He then analysed the activity of their genes, as measured by the production of a substance called messenger RNA. Healthy living: Mind and body 2011-02-24T10:45:13Z Their technique treats skin cells with messenger RNA, which transmits instructions from genes to the protein-making machinery of the cell. Researchers Report Progress on Stem Cell Alternative 2010-09-30T17:07:00Z A microRNA is a small piece of RNA that prevents the translation of messenger RNA into protein. Minimolecule May Explain How Antidepressants Work 2010-09-17T15:07:00Z If a great deal of messenger RNA for a particular gene exists in an animal’s cells, it may indicate that this gene is particularly active. 2010-01-28T10:40:00Z The level of messenger RNA from most genes was the same in both types of people. Healthy living: Mind and body 2011-02-24T10:45:13Z |
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