| 单词 | mast cell |
| 例句 | Mixed connective tissue disease, mast cell activation disorder and Lyme disease were also thrown around. Call Me Cozy 2019-03-14T04:00:00Z The test, which looks for biomarkers released by mast cells, or white blood cells forming part of the immune system, made a correct diagnosis 98% of the time in a study involving 174 children. Identifying peanut allergies cheaper and easier with new test 2018-05-02T04:00:00Z Eventually he was diagnosed with systemic mastocytosis, a disorder that results in an excess of mast cells in the body. How we stay together: 'The secret is just not leaving' 2020-10-10T04:00:00Z The researchers speculate that allergic antibodies to food may be affecting the heart by leading to the activation of specialized cells, called mast cells. Allergic responses to common foods could significantly increase risk of heart disease, cardiovascular death 2023-11-09T05:00:00Z Tryptase is found mainly in mast cells, which are white blood cells that are part of the immune system. Genetic biomarker may predict severity of food allergy 2023-09-20T04:00:00Z Mast cells are produced in the same way as white blood cells, but unlike circulating white blood cells, mast cells take up residence in connective tissues and especially mucosal tissues. Concepts of Biology 2013-04-25T00:00:00Z These allergens cause the immune system’s mast cells to release a barrage of histamine and other molecules that spread throughout the body, dilating blood vessels and narrowing airways. Nervous system may play role in severe allergic reactions 2023-03-16T04:00:00Z Their chemicals can trigger first responders in the immune system called mast cells, which can cause allergic-like reactions, she says. If you can smell your air freshener, you might have a problem 2023-02-22T05:00:00Z Persistent activation of mast cells could drive inflammation, contributing to harmful plaque buildup that can cause heart attacks or other heart damage, the researchers believe. Allergic responses to common foods could significantly increase risk of heart disease, cardiovascular death 2023-11-09T05:00:00Z A mast cell is a leukocyte that produces inflammatory molecules, such as histamine, in response to large pathogens. Biology for AP Courses 2022-06-09T00:00:00Z Figure 17.11 Cells involved in the innate immune response include mast cells, natural killer cells, and white blood cells, such as monocytes, macrophages and neutrophils. Concepts of Biology 2013-04-25T00:00:00Z During actual anaphylaxis, mast cells appear to be key to this phenomenon. Nervous system may play role in severe allergic reactions 2023-03-16T04:00:00Z Macrophages, mast cells, lymphocytes, plasma cells, and phagocytic cells are found in connective tissue proper but are actually part of the immune system protecting the body. Anatomy and Physiology 2013-06-19T00:00:00Z "I take more supplements than you want to know, and they mostly target mast cell stabilization," Jerome told Salon. As the pandemic winds down for everyone else, long Covid survivors feel left behind 2022-03-28T04:00:00Z A hypersensitive immune response to harmless antigens, such as in pollen, often involves the release of histamine by basophils and mast cells. Biology for AP Courses 2022-06-09T00:00:00Z The antibody molecules interact with mast cells embedded in connective tissues. Concepts of Biology 2013-04-25T00:00:00Z Doctors in Delaware and New York suspected she might have mast cell activation syndrome, an allergic reaction that causes flushing, before ruling that out. Medical mystery: Her unexplained jitteriness and weight loss were telling clues 2021-10-16T04:00:00Z The mast cell, found in connective tissue proper, has many cytoplasmic granules. Anatomy and Physiology 2013-06-19T00:00:00Z Also working with mice, Kim, along with scientists at Johns Hopkins University, has shown that immune system components called mast cells trigger itch neurons in the skin. A Vaccine against Poison Ivy Misery Is in the Works as Scientists Also Explore New Treatment Paths 2021-09-20T04:00:00Z Figure 33.5 In response to a cut, mast cells secrete histamines that cause nearby capillaries to dilate. Biology for AP Courses 2022-06-09T00:00:00Z Eosinophils release factors that enhance the inflammatory response and the secretions of mast cells. Concepts of Biology 2013-04-25T00:00:00Z The ailment is not an autoimmune disease in itself, but it does mean that my body systematically churns out an abundance of mast cells. How I Was Betrayed from Within 2021-09-07T04:00:00Z Like blood cells, mast cells are derived from hematopoietic stem cells and are part of the immune system. Anatomy and Physiology 2013-06-19T00:00:00Z He added that there are now drugs in Phase 3 trials — the step before approval — that eliminate the immune cells, known as mast cells, that are responsible for initiating an allergic response in the gut. Solving the Mystery of I.B.S. 2021-08-02T04:00:00Z The constant domain of the IgE molecules interact with mast cells embedded in connective tissues. Biology for AP Courses 2022-06-09T00:00:00Z On a separate track, since the 1990s, researchers have explored mast cell activity in IBS. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z My levels of tryptase, an enzyme released by mast cells, were normal. How I Was Betrayed from Within 2021-09-07T04:00:00Z In response to injury, mast cells present in tissue degranulate, releasing the potent vasodilator histamine. Anatomy and Physiology 2013-06-19T00:00:00Z While little is known about long COVID, researchers believe it is related to similar and equally puzzling syndromes — such as mast cell activation syndrome and dysautonomia — that occur following a severe viral infection. Fearing an untreated epidemic, activists fight for those with 'long COVID' symptoms 2021-04-26T04:00:00Z These IgE molecules become associated with mast cells that respond to future exposures to the protein by releasing histamines into the body. Biology for AP Courses 2022-06-09T00:00:00Z "Once the mast cell response is turned up, it doesn't wind down just because the infection is gone," explained my doctor, Leo Galland, a New York internist who specializes in difficult cases. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z The disorder causes overactive mast cells - which form part of the immune system - which trigger anaphylaxis. The disabled doctors not believed by their colleagues 2021-04-18T04:00:00Z Injured cells, mast cells, and resident macrophages release chemical signals that cause vasodilation and fluid leakage in the surrounding tissue. Anatomy and Physiology 2013-06-19T00:00:00Z One is mast cell activation syndrome, which can produce fatigue, pain and problems with thinking and memory; infection can sometimes initiate it. What If You Never Get Better From Covid-19? 2021-01-21T05:00:00Z Antihistamines prevent mast cells from becoming associated with IgE molecules that recognize the foreign protein allergen. Biology for AP Courses 2022-06-09T00:00:00Z At the turn of the century, scientists discovered anaphylaxis, the classic mast cell allergic reaction. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z In the mice—as in people with food allergies—this caused mast cells to become activated and release their chemicals. What causes IBS pain? It may be a local immune reaction 2021-01-13T05:00:00Z In the past, mast cells were considered to be basophils that left the circulation. Anatomy and Physiology 2013-06-19T00:00:00Z Silvia Fischer and her colleagues grew mast cells from mouse bone marrow in vitro. Research round-up: extracellular RNA 2020-06-16T04:00:00Z Antihistamines prevent mast cells from releasing histamines and causing the unpleasant allergy symptoms. Biology for AP Courses 2022-06-09T00:00:00Z Five decades later, in 1949, scientists described a rare genetic disorder called mastocytosis, in which mast cells produce clones, building up in the skin, bones, and other organs. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z Toxicology testing found a markedly elevated mast cell tryptase level - an increase in a released enzyme - in the blood in keeping with anaphylactic shock. Severe reaction to wasp sting killed former soldier, coroner says 2019-03-11T04:00:00Z IgE makes mast cell degranulation very specific, such that if a person is allergic to peanuts, there will be peanut-specific IgE bound to his or her mast cells. Anatomy and Physiology 2013-06-19T00:00:00Z They then treated the mast cells with chemicals that caused the cells to release RNA-containing particles called exosomes — a release that happens naturally inside the body. Research round-up: extracellular RNA 2020-06-16T04:00:00Z Antihistamines prevent histamines that have been released by mast cells from stimulating the itching and swelling of body tissues. Biology for AP Courses 2022-06-09T00:00:00Z POTS, which has been reported by patients who experienced Lyme and other infections, may involve histamine and several other chemicals released by mast cells. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z IgE activates the mast cells, which release histamine and other chemicals. A revolutionary treatment for allergies to peanuts and other foods is going mainstream—but do the benefits outweigh the risks? 2018-10-18T04:00:00Z In this person, eating peanuts will cause the mast cells to degranulate, sometimes causing severe allergic reactions, including anaphylaxis, a severe, systemic allergic response that can cause death. Anatomy and Physiology 2013-06-19T00:00:00Z The results suggest that extracellular RNA from mast cells spurs the inflammation that degrades vascular health. Research round-up: extracellular RNA 2020-06-16T04:00:00Z Antihistamines prevent mast cells from producing histamines, which halts their effect on the body. Biology for AP Courses 2022-06-09T00:00:00Z In the meantime, you might not need to fit either group's criteria for MCAS, a difficult and chronic illness, to experience your mast cells' betraying you sometimes. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z The therapy also produces other immunoglobulins: IgG4, which further inhibits mast cell activity, and IgA, which helps keep food allergens from escaping the gut. A revolutionary treatment for allergies to peanuts and other foods is going mainstream—but do the benefits outweigh the risks? 2018-10-18T04:00:00Z As these mediators are released with mast cell degranulation, type I hypersensitivity reactions are usually rapid and occur within just a few minutes, hence the term immediate hypersensitivity. Anatomy and Physiology 2013-06-19T00:00:00Z Further blood and tissue samples indicated the tiger had mast cell leukemia. Necropsy: Hattiesburg Zoo’s Sumatran tiger died of leukemia 2017-06-02T04:00:00Z Federal prosecutors say an investigation found that Poplar promoted the test as a way to diagnose a condition known as “mast cell enterocolitis.” Tennessee lab testing company to pay $900,000 settlement 2017-05-01T04:00:00Z If mast cell dysfunction is truly common, I trust the online buzz to help us find out. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z It contains cromolyn, which stabilizes the mast cells in the nose responsible for allergy symptoms. Coated aspirin may be riskier for digestive tract 2017-04-09T04:00:00Z The granules of eosinophils include antihistamine molecules, which counteract the activities of histamines, inflammatory chemicals produced by basophils and mast cells. Anatomy and Physiology 2013-06-19T00:00:00Z Researchers found that the drug at least partly reversed organ damage in 60 percent of patients with advanced systemic mastocytosis -- an umbrella term for several rare cancers that affect blood cells called mast cells. New Drug Shows Promise for Rare Blood Cancers 2016-06-29T04:00:00Z Omalizumab is a monoclonal antibody that binds to IgE antibodies and prevents them from glomming on to mast cells, which triggers the allergic cascade. An Overreaction to Food Allergies 2015-11-10T05:00:00Z Before the pandemic, researchers had suggested that mast cell dysfunction could explain severe cases of the flu — and highlighted the cells' role in shutting down inflammation in a variety of situations. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z At least one targeted therapy already exists for mast cell tumors, homing in on an aberrant protein implicated in the unruly growth of these common skin masses in dogs. Learning From Dogs With Cancer 2015-10-21T04:00:00Z The specificity of the immediate hypersensitivity response is predicated on the binding of allergen-specific IgE to the mast cell surface. Anatomy and Physiology 2013-06-19T00:00:00Z In aggressive cases of systemic mastocytosis, abnormal mast cells build up in the bone marrow, skin, gut, spleen, liver and lymph nodes. New Drug Shows Promise for Rare Blood Cancers 2016-06-29T04:00:00Z The antibody binds to immune cells called mast cells, which then triggers release of a cascade of chemicals that produce all kinds of inflammation and irritation. An Overreaction to Food Allergies 2015-11-10T05:00:00Z In my case, probably because of a genetic peculiarity, my mast cells overreact. Immune system mutiny: mast cells and the mystery of long COVID 2021-07-04T04:00:00Z Quantitative differences in antigen affinity thus determine the quality of mast cell responses. [Perspective] Signaling Shifts in Allergy Responses 2014-02-27T19:26:11.597Z Treatment with mast cell inhibitors reduced the immigration of T cells, suggesting that mast cells play a role in the EGFRI-mediated skin pathology. [Research Articles] Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation 2013-08-21T18:25:06.503Z That mutation occurs in a protein called KIT, which controls the growth of mast cells. New Drug Shows Promise for Rare Blood Cancers 2016-06-29T04:00:00Z Before lesion development, we detected increased mRNA expression of chemokines in the skin associated with early infiltration of macrophages and mast cells and later infiltration of eosinophils, T cells, and neutrophils. [Research Articles] Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy 2013-08-21T18:25:05.013Z The immune system is complex: in general the part of the immune system that drives inflammatory arthritis is different from the part that drives allergies, but there are cells that overlap, like mast cells. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z Those IgE antibodies coat the surface of mast cells, which are filled with a bunch of reactive molecules like histamines that make your immune system freak out. Allergic to Science-Proteins and Allergens in Our Genetically Engineered Food 2013-05-30T13:15:00.333Z Kormuro’s research explores “the molecular mechanisms underlying mutual regulation between cardiovascular cells and the immune system including mast cells and T lymphocytes and advance translational research.” Suspicions Raised About Another Japanese Cardiovascular Researcher 2013-05-10T21:09:05Z Normally, mast cells release histamines and other chemicals during inflammatory and allergic reactions. New Drug Shows Promise for Rare Blood Cancers 2016-06-29T04:00:00Z Another type of immune cell under investigation is the mast cell. Psychodermatology: An emotional response 2012-12-19T18:21:00.890Z That molecule triggers a cellular process known as degranulation which encourages histamine to be released from your white blood cells, known as mast cells. Finnish Scientists Discover Vaccine To Eliminate Allergies 2012-05-29T18:16:16Z Masitinib targets mast cells, which help govern immunity, and kinases, a type of enzyme that plays a role in the growth of cancerous cells. AB Soars 46% as Cancer Drug Beats Pfizer’s Sutent: Paris Mover 2012-02-02T16:38:23Z “What we found was that the mast cell function was actually inhibited.” UMaine Researchers Probe Arsenic Effects on Cells, Immune System 2010-08-20T15:04:00Z And this conclusion is strengthened by comparison with the behaviour of the mast cells, which are related to the eosinophils in many points, and only differ from them essentially in the nature of their granulation. Histology of the Blood Normal and Pathological “The mast cell participates in the early phases and may direct this entire system.” Psychodermatology: An emotional response 2012-12-19T18:21:00.890Z Nuclei are blue, hæmoglobin red, neutrophil granulation violet, acidophil pure red, mast cell granulation deep blue, forming one of the most beautiful microscopic pictures. Histology of the Blood Normal and Pathological The mast cells stand out by "negative staining" as peculiar bright, almost white cells, with nuclei of a pale green colour. Histology of the Blood Normal and Pathological The team used mammalian mast cells commonly used to model human mast cell function. UMaine Researchers Probe Arsenic Effects on Cells, Immune System 2010-08-20T15:04:00Z In the case of the mast cells, then, we see the conditions actually realised, which the supporters of the theory of the local origin of the eosinophil cells only assume. Histology of the Blood Normal and Pathological Like Langerhans cells, mast cells are found in large numbers in the upper layers of the skin, near nerve fibres. Psychodermatology: An emotional response 2012-12-19T18:21:00.890Z The nuclei and the mast cell granulations stain deep blue, malaria plasmodia light sky blue, red corpuscles and eosinophil granules a fine red. Histology of the Blood Normal and Pathological The mast cell granulations are stained pure blue, the eosinophil red, the neutrophil in mixed colour. Histology of the Blood Normal and Pathological The next phase of the research will look at the molecular mechanism underlying arsenic’s effects on mast cells. UMaine Researchers Probe Arsenic Effects on Cells, Immune System 2010-08-20T15:04:00Z In 22 healthy persons Canon entirely failed to find the mast cells on nine occasions, in the others he found on the average 0.47%; the highest percentage number obtained was 0.89%. Histology of the Blood Normal and Pathological Animal studies designed to promote stress — for example, exposing mice to loud noise — show activation of mast cells in the skin. Psychodermatology: An emotional response 2012-12-19T18:21:00.890Z The eosinophil and mast cells were plainly increased. Histology of the Blood Normal and Pathological The eosinophils on the contrary were increased distinctly, the mast cells to a lesser extent. Histology of the Blood Normal and Pathological Arnold, explain this double staining of the eosinophil cells by the presence of eosinophil and mast cell granulation side by side. Histology of the Blood Normal and Pathological Hence it follows that the mast cells undergo an increase in number relatively greater than the eosinophil cells, for they normally amount only to some 0.28%. Histology of the Blood Normal and Pathological Activated mast cells release substances such as histamine that can stimulate the growth of sensory nerve fibres, which are more prevalent in psoriatic lesions. Psychodermatology: An emotional response 2012-12-19T18:21:00.890Z That this is certainly not the case is shewn by the fact that the "basophil" granulation of the eosinophil cells does not in metachromatic staining shew the metachromasia characteristic for the mast cells. Histology of the Blood Normal and Pathological Earlier observations, especially on the mast cells, led me to expect that these granulations, though they had long been inaccessible to chemical analysis, could be distinguished by their behaviour with certain stains. Histology of the Blood Normal and Pathological We can diagnose the variously shaped mast cells only by the staining of their granules in dahlia solution, that is by a microchemical test. Histology of the Blood Normal and Pathological The substances which attract the mast cells are very rarely produced in the body; much more seldom than the corresponding substances attractive for the eosinophils. Histology of the Blood Normal and Pathological The substance of the mast cell granulations is also crystalline in some species of animals. Histology of the Blood Normal and Pathological The size of the individual granules is constant in any animal species for every kind of granule—excepting only the mast cells. Histology of the Blood Normal and Pathological The contrary assertions that neutrophil and eosinophil, or eosinophil and mast cell granulations occur in the same cell Ehrlich regards as unfounded, from extensive researches specially directed to this point. Histology of the Blood Normal and Pathological Still greater is the difference between the mast cells and the other two cell groups; for so far as present investigations go, they are quite uninfluenced by substances chemiotactic for the neutrophil or eosinophil cells. Histology of the Blood Normal and Pathological In morbid conditions, where substances attracting the mast cells were present, it might be possible to find a suppuration of mast cells, or a mast cell leucocytosis as well. Histology of the Blood Normal and Pathological In fact appearances of the mast cells are not infrequently found, which must be referred to excretory processes of this kind. Histology of the Blood Normal and Pathological In the first place it is occasionally seen that the mast cell granulation is dissolved within the cell, and diffuses in solution into the nucleus. Histology of the Blood Normal and Pathological Still more convincing is the presence of a peculiar halo of the mast cells, described by various authors. Histology of the Blood Normal and Pathological Evidently part of the dyed mast cell substance is dissolved and retained in the immediate neighbourhood. Histology of the Blood Normal and Pathological Under the influence of stagnation of the milk he saw an invasion of the gland tissue by typical mast cells. Histology of the Blood Normal and Pathological A condition that Prus has brought forward in the so-called purpura of the horse, is also to be interpreted as a secretory process of the mast cells. Histology of the Blood Normal and Pathological That such a process is possible, is proved by the local origin of the mast cells. Histology of the Blood Normal and Pathological We know that the mast cells are produced in large quantities locally, wherever an over-nutrition of the connective tissue occurs, for instance in chronic diseases of the skin, elephantiasis, brown induration of the lungs. Histology of the Blood Normal and Pathological We should therefore expect that an increase of mast cells in the blood or in certain inflammatory exudations would be by no means seldom. Histology of the Blood Normal and Pathological Occasionally a stain is desirable which only brings out, but in a characteristic manner, a special kind of cell, e.g. the eosinophils, mast cells, or bacteria. Histology of the Blood Normal and Pathological A leucocytosis of mast cells, comparable with the eosinophil or neutrophil forms of leucocytosis, has not been demonstrated in the cases of Canon or other observers. Histology of the Blood Normal and Pathological On the other hand, the mast cells undergo a considerable increase in myelogenic leukæmia, in many cases equalling or even exceeding that of the eosinophils. Histology of the Blood Normal and Pathological |
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