| 单词 | macrophage |
| 例句 | The amebocytes of starfish were recently found to contain a material that immobilizes the macrophages of mammals, resembling a product of immune lymphocytes in higher forms. The Lives of a Cell 1974-01-01T00:00:00Z Her subject was macrophages, big, hungry cells on the front lines of the defense. Is Our Obsession With Wellness Doing Us In? 2018-06-11T04:00:00Z Microscopic cells called macrophages make their own “decisions”, and not always to our benefit – they can aid the growth of tumours and attack other cells, with life-threatening results. When do you know you're old enough to die? Barbara Ehrenreich has some answers 2018-04-07T04:00:00Z Tuberculosis establishes a complex presence in the people it infects: Upon entering the body usually through the lungs, it is engulfed by immune cells called macrophages. Three Books That Track Diseases, Drugs and the World They Made 2017-12-29T05:00:00Z A large sculpture shows a macrophage, or immune cell, on the attack against a swarm of disease-causing Staphylococcus bacteria. Review: ‘The Secret World Inside You’ Explores the Microbial Human 2015-11-05T05:00:00Z In the lab, macrophages show a lot of promise in treating cancer but so far, clinical trials have been a disappointment and biologists are trying to figure out why. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z "Our results indicate that drugs targeting senescent macrophages could be a treatment for cancer -- an unprecedented development," concluded Wada. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z Fish deploy many of the same pathogen fighters, including T cells, B cells, and macrophages. Why don’t fish have tonsils? They have a good alternative, study suggests 2023-10-31T04:00:00Z Instead, immune cells and microglia, a kind of macrophage, proliferate in the aging brain. New method tracks how brain cells age 2023-10-26T04:00:00Z Although normally monocytes and macrophages were not known as the primary defense force against viruses, the authors found that they activated other immune cells, so-called natural killer cells, that help fight the virus. Boosting weak immune system: Scientists find an unusual weapon against virus 2023-10-17T04:00:00Z "Our engineering approach led us to question whether the poor therapeutic outcome of macrophages in cell therapies can in part originate from their inability to get into the tumor in the first place," said Mitragotri. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z The experimental vaccine takes an entirely different approach: It gooses the body's preexisting supply of pathogen-gobbling immune cells called macrophages, which engulf and digest bacteria, fungi and other bad actors. Hospital superbugs: Could one vaccine rule them all? 2023-10-04T04:00:00Z Rodents lacking functional macrophages, sentinel cells that engulf pathogens and are required for the innate immune response, fared much worse. Immunity-enhancing cocktail protects mice against multiple hospital germs 2023-10-03T04:00:00Z Secondly, these cancer cells also deceive the body in insidious ways: they even recruit immune cells called macrophages to help them. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z There are multiple types of macrophages, simplified as M0, M1, and M2. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z They showed that cancer stem cells induce senescence in macrophages -- the immune cells which are responsible for the first step of the destruction of cancer cells. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z Much of that work has focused on myeloid immune cells, most notably macrophages and their brain-resident versions known as microglia. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z For example, the researchers showed the cocktail triggers changes in gene activity in macrophages, but it’s not clear how they lead to protection against infection. Immunity-enhancing cocktail protects mice against multiple hospital germs 2023-10-03T04:00:00Z She saw the zebrafish's immune system sending macrophages as part of an immune response to control the tumor. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z Of the three, M1 macrophages have the best tumor-fighting capacities and therefore have been used the most for cell therapies. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z In mice models, the cancer stem cells suppressed the proliferation of macrophages; further investigation showed that macrophages cultured with cancer stem cells exhibit senescence or cellular aging. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z Both, the researchers show, are produced by neutrophils themselves as well as macrophages and microglia. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z In the spleen, most of the infected cells detected were frontline immune cells -- macrophages and monocytes -- known as phagocytes whose job is to swallow up invading organisms. A lethal parasite's secret weapon: Infecting non-immune cells 2023-09-29T04:00:00Z But as is typical in glioblastoma, the macrophages were suppressed. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z It's well known that macrophages exist in various shapes and some phenotypes are really good at changing their shape. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z Macrophages were not the only immune cells affected; while the proliferation of T cells was unchanged, their antitumor activity was suppressed due to the immunosuppressive factors produced by senescent macrophages. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z "We found TXN mainly works by reducing the abundance of gut microbes that promote inflammation in the adipose tissue's macrophage cells, and improving glucose metabolism," Morgun said. Compound derived from hops reduces abundance of gut microbe associated with metabolic syndrome 2023-09-21T04:00:00Z He says that unwanted interactions between CAR T and immune cells called macrophages drive the overactivation of macrophages, which in turn result in the release of toxic cytokines that lead to CRS and neurotoxicity. A suit of armor for cancer-fighting cells 2023-09-18T04:00:00Z And a clue surfaced when they noticed that the tumor of one patient did not suppress the normal macrophage response. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z Adebowale and the team found a correlation between shape-shifting abilities and transport efficiency -- meaning the better the macrophage was at shape shifting, the better able they were to get to the tumor. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z And in some tissues of adult rodents, the immune cells known as macrophages are descended from yolk sac cells, not the bone marrow cells that give rise to most macrophages. Three organs in one? Researchers unscramble mysterious roles of human yolk sac 2023-08-16T04:00:00Z For example, scientists have found that bilirubin may steer immune cells called macrophages to curtail their secretion of inflammatory molecules. Can ‘toxic’ bilirubin treat a variety of illnesses? 2023-06-08T04:00:00Z This is made possible, Gong says, due to the size differences among tumor cells, CAR T cells, and macrophages. A suit of armor for cancer-fighting cells 2023-09-18T04:00:00Z When they cultured the tumor cells and macrophages together and did single-cell RNA sequencing, they learned that one gene, LGALS1, was downregulated in the tumor of the long-term survivor compared to the others. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z And, as it turned out, M1 macrophages are the worst of the three when it comes to shapeshifting. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z Only 4 weeks after conception, the structure harbored blood-forming stem cells, macrophages, and other kinds of circulatory system cells, the team reports. Three organs in one? Researchers unscramble mysterious roles of human yolk sac 2023-08-16T04:00:00Z As illustrated in Figure 1, loose connective tissue has some fibroblasts; macrophages are present as well. Fundamentals of Biology 2015-01-01T00:00:00Z Figure 3.12 A macrophage has phagocytized a potentially pathogenic bacterium into a vesicle, which then fuses with a lysosome within the cell so that the pathogen can be destroyed. Concepts of Biology 2013-04-25T00:00:00Z To understand how macrophages can interact with glioblastoma cells of different patients, the researchers created zebrafish "avatars." Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z "Our study demonstrates that the reduced transport of M1 macrophages compared to M0 macrophages is correlated with their reduced ability to undergo shape transformations," said Adebowale. Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z The team also discovered that the yolk sac uses an unexpected shortcut to produce macrophages. Three organs in one? Researchers unscramble mysterious roles of human yolk sac 2023-08-16T04:00:00Z Interferons can also activate other immune cells such as macrophages and natural killer cells. Fundamentals of Biology 2015-01-01T00:00:00Z Antibodies also mark pathogens for destruction by phagocytic cells, such as macrophages or neutrophils, in a process called opsonization. Concepts of Biology 2013-04-25T00:00:00Z The tumors have several mechanisms to reprogram the macrophages so they help them grow. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z "We hope that these findings shed new light on the biophysics of macrophage migration and delivery of macrophage cell therapies." Shape-shifting immune cells offer new insights into cancer immunotherapy 2023-11-16T05:00:00Z As one of these immune cells matures, it usually goes through an intermediate stage known as a monocyte, but the yolk sac macrophages bypass this step. Three organs in one? Researchers unscramble mysterious roles of human yolk sac 2023-08-16T04:00:00Z Monocytes give rise to phagocytic macrophages that clean up dead and damaged cells in the body, whether they are foreign or from the host animal. Fundamentals of Biology 2015-01-01T00:00:00Z For example, a monocyte is a type of white blood cell that circulates in the blood and lymph and develops into a macrophage after it moves into infected tissue. Concepts of Biology 2013-04-25T00:00:00Z The examinations suggested that immune cells called macrophages had been stirred up. Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments 2023-02-14T05:00:00Z When we injected a lethal dose of TNF in mice lacking the two proteins in two specific types of myeloid cells, neutrophils and macrophages, mice had reduced symptoms of sepsis and improved survival. How sepsis can lead to cell death 2023-01-01T05:00:00Z The scientists also tested whether, like in mice, yolk sac–derived macrophages are still present in adult tissues. Three organs in one? Researchers unscramble mysterious roles of human yolk sac 2023-08-16T04:00:00Z As illustrated in Figure 24.12, loose connective tissue has some fibroblasts; macrophages are present as well. Biology for AP Courses 2022-06-09T00:00:00Z A macrophage is a large cell that engulfs foreign particles and pathogens. Concepts of Biology 2013-04-25T00:00:00Z But the white blood cells called macrophages, which are born in the bone marrow, slip into the heart. Men lose Y chromosomes as they age. It may be harming their hearts 2022-07-13T04:00:00Z This finding positions macrophages and neutrophils as major triggers for TNF-mediated death in mice. How sepsis can lead to cell death 2023-01-01T05:00:00Z Osteoclasts develop from monocytes and macrophages and differ in appearance from other bone cells. Anatomy and Physiology 2013-06-19T00:00:00Z Monocytes differentiate into macrophages and dendritic cells, which in turn respond to infection or injury. Biology for AP Courses 2022-06-09T00:00:00Z Figure 17.11 Cells involved in the innate immune response include mast cells, natural killer cells, and white blood cells, such as monocytes, macrophages and neutrophils. Concepts of Biology 2013-04-25T00:00:00Z The scientists found that many of the macrophages from mice lacking the Y chromosome began to promote fibrosis, stimulating other cells in the heart to spin more connective tissue. Men lose Y chromosomes as they age. It may be harming their hearts 2022-07-13T04:00:00Z But certain immune cells called macrophages also could be infected, and they developed a robust inflammatory response. The Coronavirus Attacks Fat Tissue, Scientists Find 2021-12-08T05:00:00Z The macrophage cell is a large cell derived from a monocyte, a type of blood cell, which enters the connective tissue matrix from the blood vessels. Anatomy and Physiology 2013-06-19T00:00:00Z After the HIV virus replicates, it is transmitted directly from the infected T cell to macrophages. Biology for AP Courses 2022-06-09T00:00:00Z Instead, dendritic cells and macrophages first engulf and digest pathogens into hundreds or thousands of antigens. Concepts of Biology 2013-04-25T00:00:00Z When monocytes encounter an atherosclerotic plaque on the side of a blood vessel, they morph into macrophages and release inflammation-inciting molecules called cytokines. Immune Cells That Remember Inflammation Could Offer Treatment Targets for Atherosclerosis 2021-12-01T05:00:00Z It also contains pre-adipocytes, which mature into fat cells, and a variety of immune cells, including a type called adipose tissue macrophages. The Coronavirus Attacks Fat Tissue, Scientists Find 2021-12-08T05:00:00Z The macrophage cells are an essential component of the immune system, which is the body’s defense against potential pathogens and degraded host cells. Anatomy and Physiology 2013-06-19T00:00:00Z A macrophage is a large phagocytic cell that engulfs foreign particles and pathogens. Biology for AP Courses 2022-06-09T00:00:00Z Liver cells and macrophages synthesize inactive forms of complement proteins continuously; these proteins are abundant in the blood serum and are capable of responding immediately to infecting microorganisms. Concepts of Biology 2013-04-25T00:00:00Z As blood passes through the spleen, immune cells called macrophages ordinarily devour old and damaged red blood cells. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z To make the nanosponges, Zhang’s team starts with human cells such as red blood cells or immune cells known as macrophages. Nanotechnology Offers New Ways to Fight an Endless Pandemic 2021-10-15T04:00:00Z When stimulated, macrophages release cytokines, small proteins that act as chemical messengers. Anatomy and Physiology 2013-06-19T00:00:00Z PRRs are molecules on macrophages and dendritic cells which are in contact with the external environment. Biology for AP Courses 2022-06-09T00:00:00Z After phagocytosis by a macrophage, the phagocytic vesicle fuses with an intracellular lysosome. Concepts of Biology 2013-04-25T00:00:00Z But in the test tube, the researchers found, an encounter with CpG-carrying DNA causes the cells to conceal the portion of this protein that rebuffs macrophages. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z Many critical immune cells, including T cells and macrophages, feature receptors for progesterone on their surface. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z Roaming, or free, macrophages move rapidly by amoeboid movement, engulfing infectious agents and cellular debris. Anatomy and Physiology 2013-06-19T00:00:00Z A monocyte is a type of white blood cell that circulates in the blood and lymph and differentiates into macrophages after it moves into infected tissue. Biology for AP Courses 2022-06-09T00:00:00Z Microglia are related to immune cells called macrophages that patrol the body to combat pathogens or help repair injured tissue. Immune Cells Suggest New Alzheimer’s Treatment Possibilities 2021-07-26T04:00:00Z When the researchers transfused red blood cells into the animals, macrophages in their spleens gobbled cells that had been exposed to CpG-laden DNA, but ate fewer red blood cells that hadn’t encountered the DNA. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z It decreases the responses of immune cells, including neutrophils, natural killer cells and macrophages—which could be one reason that men tend to have lower rates of autoimmune disease. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z In contrast, fixed macrophages are permanent residents of their tissues. Anatomy and Physiology 2013-06-19T00:00:00Z Both macrophages and dendritic cells engulf pathogens and cellular debris through phagocytosis. Biology for AP Courses 2022-06-09T00:00:00Z A third pathway concerns the infiltration of immune cells called macrophages in adipose tissue. Why Are People with Obesity More Vulnerable to COVID? 2021-06-24T04:00:00Z The red blood cells then sacrifice themselves by encouraging macrophages to eat them, alert the immune system, and trigger inflammation. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z And they found that the brains were permeated by immune cells called macrophages, which act like garbage trucks — prowling for pathogens and then attacking and removing them. How COVID-19 can damage the brain 2021-06-23T04:00:00Z Microglia protect the nervous system against infection but are not nervous tissue because they are related to macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z Neutrophils, dendritic cells and macrophages release chemicals to stimulate the inflammatory response. Biology for AP Courses 2022-06-09T00:00:00Z Baxter’s song went viral, teaching nearly three million listeners across several platforms about B cells, macrophages and opsonization. These Videos Could Boost COVID Vaccination Rates 2021-06-22T04:00:00Z If macrophages consume too many red blood cells, however, anemia may result. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z White blood cells called neutrophils and macrophages travel to the intruder and work to destroy it. Vaccine side effects don’t tell you how well your immune system will protect you from covid-19 2021-05-07T04:00:00Z The endothelium lining the local blood vessel becomes “leaky” under the influence of histamine and other inflammatory mediators allowing neutrophils, macrophages, and fluid to move from the blood into the interstitial tissue spaces. Anatomy and Physiology 2013-06-19T00:00:00Z Neutrophils and macrophages also consume invading bacteria by phagocytosis. Biology for AP Courses 2022-06-09T00:00:00Z Immunologist Paul Kubes of the University of Calgary and colleagues chanced on the connection between macrophages and the buildup of abdominal scar tissue. These bacteria-gobbling immune cells help the body heal—but also cause surgical complications 2021-03-04T05:00:00Z Davenport adds that anemia in patients with sepsis can result from several causes and there’s little evidence that excessive macrophage consumption of red blood cells is responsible. Red blood cells may be immune sentinels 2021-10-19T04:00:00Z Neutrophils or macrophages in your body notice the vaccine molecules and produce cytokines — molecular signals that cause fever, chills, fatigue and muscle pain. Vaccine side effects don’t tell you how well your immune system will protect you from covid-19 2021-05-07T04:00:00Z They are found on bone surfaces, are multinucleated, and originate from monocytes and macrophages, two types of white blood cells, not from osteogenic cells. Anatomy and Physiology 2013-06-19T00:00:00Z Cells of the liver and macrophages synthesize complement proteins continuously; these proteins are abundant in the blood serum and are capable of responding immediately to infecting microorganisms. Biology for AP Courses 2022-06-09T00:00:00Z “This is a clear and cool example of the role of macrophages in wound healing,” says immunologist David Mosser of the University of Maryland, College Park, who wasn’t connected to the study. These bacteria-gobbling immune cells help the body heal—but also cause surgical complications 2021-03-04T05:00:00Z For starters, Dr. Evans said, fever activates innate immunity — the mobilization of white blood cells: neutrophils that patrol the body for pathogens and macrophages that gobble them up. Why Are We So Afraid of Fevers? 2021-01-11T05:00:00Z For example, immune cells called alveolar macrophages in the lung suppress inflammation once the threat posed by the pathogen diminishes. Why Do Some People Weather Coronavirus Infection Unscathed? 2020-08-25T04:00:00Z Ongoing research into these cells, although not entirely conclusive, suggests that they may originate as white blood cells, called macrophages, that become part of the CNS during early development. Anatomy and Physiology 2013-06-19T00:00:00Z The proteins serve as a marker to indicate the presence of a pathogen to phagocytic cells, such as macrophages and B cells, and enhance engulfment; this process is called opsonization. Biology for AP Courses 2022-06-09T00:00:00Z But the macrophages apparently can’t cope with the severe tissue trauma caused by surgery. These bacteria-gobbling immune cells help the body heal—but also cause surgical complications 2021-03-04T05:00:00Z That's due to inflammation driven by immune cells called macrophages which invade our fat tissue. Coronavirus: Does weight affect how ill people get? 2020-05-07T04:00:00Z Some research from earlier coronavirus outbreaks does, in fact, lend support to the idea that antibodies could trigger inflammatory pathology by co-opting macrophages. COVID-19 Vaccine Developers Search for Antibodies That ‘First Do No Harm’ 2020-05-28T04:00:00Z While their origin is not conclusively determined, their function is related to what macrophages do in the rest of the body. Anatomy and Physiology 2013-06-19T00:00:00Z Figure 33.8 An APC, such as a macrophage, engulfs and digests a foreign bacterium. Biology for AP Courses 2022-06-09T00:00:00Z “I suspect that the adhesions are an inappropriate response” by the macrophages, Kubes says. These bacteria-gobbling immune cells help the body heal—but also cause surgical complications 2021-03-04T05:00:00Z A specific type of fat tissue is prone to macrophage invasion. Coronavirus: Does weight affect how ill people get? 2020-05-07T04:00:00Z The transferred antibodies worsened disease and seemed to switch lung macrophages from a protective to a pathogenic state, as judged by an examination of the immune cells’ genetic activity. COVID-19 Vaccine Developers Search for Antibodies That ‘First Do No Harm’ 2020-05-28T04:00:00Z When macrophages encounter diseased or damaged cells in the rest of the body, they ingest and digest those cells or the pathogens that cause disease. Anatomy and Physiology 2013-06-19T00:00:00Z TH1 cells secrete cytokines to enhance the activities of macrophages and other T cells. Biology for AP Courses 2022-06-09T00:00:00Z Senescent cells also draw elements of the immune system, including macrophages and natural killer cells, to their location. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z That's due to immune cells called macrophages which live in our fat causing real problems when they are too active. Does obesity increase the risk of coronavirus? 2020-05-07T04:00:00Z The ideal counter, then, would be a drug that blocks IL-6 activity and reduces the flow of macrophages into the lungs. How does COVID-19 kill? Uncertainty is hampering doctors’ ability to choose treatments 2020-04-08T04:00:00Z Microglia are the cells in the CNS that can do this in normal, healthy tissue, and they are therefore also referred to as CNS-resident macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z Recall the frontline defenses of macrophages involved in the innate immune response. Biology for AP Courses 2022-06-09T00:00:00Z This includes defensins, the ancient antimicrobial proteins that mobilize cellular pathways in the fight against pathogens, and macrophages, the white blood cells that scavenge and devour all things foreign. Can We Really Develop a Safe, Effective Coronavirus Vaccine? 2020-04-06T04:00:00Z For the most part, macrophages—the large immune cells that consume pathogens—are first responders. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z The polyester in the implant is porous and attracts immune cells such as macrophages, which in turn coax circulating tumour cells to attach on to the scaffold. Research round-up: Cancer diagnosis 2020-03-24T04:00:00Z Injured cells, mast cells, and resident macrophages release chemical signals that cause vasodilation and fluid leakage in the surrounding tissue. Anatomy and Physiology 2013-06-19T00:00:00Z Some intracellular bacteria, such as Mycobacterium tuberculosis, have evolved to multiply in macrophages after they have been engulfed. Biology for AP Courses 2022-06-09T00:00:00Z The innate immune system, composed of white blood cells such as macrophages, natural killer cells and neutrophils, was supposed to have no such memory. Can a century-old TB vaccine steel the immune system against the new coronavirus? 2020-03-23T04:00:00Z At the time, his lab was studying a similar group of macrophages—not in the lungs but in the spleen, a blood-filtering organ in the lymphatic system. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z The authors examined six metabolites released from all apoptotic cells and found that none, individually, had a significant effect on the gene-expression profile of macrophages. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z Interspersed among the keratinocytes of this layer is a type of dendritic cell called the Langerhans cell, which functions as a macrophage by engulfing bacteria, foreign particles, and damaged cells that occur in this layer. Anatomy and Physiology 2013-06-19T00:00:00Z These pathogens evade attempts by macrophages to destroy and digest the pathogen. Biology for AP Courses 2022-06-09T00:00:00Z But pollution particles slow down the alveolar macrophages. The coronavirus is dangerous. But some experts wonder if bad air makes it worse. 2020-03-15T04:00:00Z When the researchers depleted the macrophages using a clever genetic strategy, the mice died just two days after being infected with small amounts of Listeria bacteria they would normally clear. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z Intriguingly, the authors found that the epigenetic therapy caused monocytes to differentiate into a type of cell called an interstitial macrophage, which might lack the ability to promote tumour establishment at a secondary site. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Some macrophages occupy fixed locations, whereas others wander through the tissue fluid. Anatomy and Physiology 2013-06-19T00:00:00Z When M. tuberculosis infection occurs, macrophages can stimulate naïve T cells to become TH1 cells. Biology for AP Courses 2022-06-09T00:00:00Z When exposed to particulates from diesel exhaust and brake dust, the researchers found the ability of the macrophages to destroy bacteria was reduced. Toxic brake dust 'could cause London throat' 2020-01-09T05:00:00Z Another one was also striking: while other immune cells packed infection-fighting zones in the spleen, this group of macrophages stayed put. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z The epigenetic therapy also caused some monocytes to differentiate into a cell called an interstitial macrophage. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Following platelet release, megakaryocyte remnants, which are little more than a cell nucleus, are consumed by macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z These stimulated T cells secrete specific cytokines that send feedback to the macrophage to stimulate its digestive capabilities and allow it to destroy the colonizing M. tuberculosis. Biology for AP Courses 2022-06-09T00:00:00Z Voracious eaters, they ingest lipids that accrue in plaques, before morphing into larger, less agile macrophages. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z In this complex organ, the vast majority of macrophages live in tiny air sacs called alveoli. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z Instead, research in mice shows that they trigger immune cells called macrophages to repair connective tissue in damaged regions of the organ. Daily briefing: “We are in a state of planetary emergency” 2019-11-27T05:00:00Z Immune cells, such as macrophages, roam the area and engulf any foreign matter to reduce the chance of infection. Anatomy and Physiology 2013-06-19T00:00:00Z In the same manner, TH1-activated macrophages also become better suited to ingest and kill tumor cells. Biology for AP Courses 2022-06-09T00:00:00Z In parallel, the authors performed single-cell RNA sequencing of immune cells retrieved from plaques, and found an increase in platelet-specific factor Pf4 on macrophages, suggesting that platelet adherence persisted beyond monocyte recruitment. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z “The whole airway branch gets lit up with these macrophages,” Khanna says. Could Newly Found “Peacekeeping” Cells Be a Weapon against COVID-19? 2020-03-27T04:00:00Z In other experiments, the researchers suppressed macrophage activity in some mice. Stem-cell therapies use immune system to repair broken hearts 2019-11-26T05:00:00Z Dendritic cells and macrophages within this organ internalize and kill many of the pathogens that pass through, thereby removing them from the body. Anatomy and Physiology 2013-06-19T00:00:00Z APCs of the mucosal immune system are primarily dendritic cells, with B cells and macrophages having minor roles. Biology for AP Courses 2022-06-09T00:00:00Z Platelets, it seemed, were also aggregating with macrophages. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z They found that a cellular plug in the fascia, consisting of extracellular matrix, macrophages, blood vessels and nerves, moved upwards into the damaged skin to form a scar. Ready-made cellular plugs heal skin wounds 2019-11-26T05:00:00Z Today in Nature, Molkentin’s team reports that two common stem-cell therapies trigger immune cells called macrophages that help to repair connective tissue in the damaged area of the heart, which improves its function1. Stem-cell therapies use immune system to repair broken hearts 2019-11-26T05:00:00Z Phagocytic cells such as macrophages and neutrophils are attracted to an infection site by chemotactic attraction to smaller complement fragments. Anatomy and Physiology 2013-06-19T00:00:00Z Lymph nodes scattered throughout the body, as illustrated in Figure 33.20, house large populations of T and B cells, dendritic cells, and macrophages. Biology for AP Courses 2022-06-09T00:00:00Z In addition to inducing inflammatory-molecule production, platelets impaired macrophages’ capacity to ingest dying cells through efferocytosis, increasing the number of undigested dying cells in plaques — a phenomenon that increases the likelihood of plaque rupture. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z The fascia contains EPFs, extracellular matrix, blood vessels, nerves and immune cells called macrophages. Ready-made cellular plugs heal skin wounds 2019-11-26T05:00:00Z Immune cells called macrophages were swollen with fat, an abnormality. How safe is vaping? New human studies assess chronic harm to heart and lungs 2019-11-26T05:00:00Z The alveolar wall consists of three major cell types: type I alveolar cells, type II alveolar cells, and alveolar macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z The spleen houses B and T cells, macrophages, dendritic cells, and NK cells. Biology for AP Courses 2022-06-09T00:00:00Z In plaques, monocytes ingest lipids and transform into macrophage cells. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z At Carisma, Gill and his colleagues look to get around these obstacles though a different immune cell called the macrophage. Behind the Scenes of a Radical New Cancer Cure 2019-11-09T05:00:00Z Affected mice seemed healthy, but when Kheradmand exposed them to a flu virus, those with swollen macrophages died, suggesting their ability to battle infection had weakened. How safe is vaping? New human studies assess chronic harm to heart and lungs 2019-11-26T05:00:00Z Roaming around the alveolar wall is the alveolar macrophage, a phagocytic cell of the immune system that removes debris and pathogens that have reached the alveoli. Anatomy and Physiology 2013-06-19T00:00:00Z Antibodies also mark pathogens for destruction by phagocytic cells, such as macrophages or neutrophils, because phagocytic cells are highly attracted to macromolecules complexed with antibodies. Biology for AP Courses 2022-06-09T00:00:00Z Platelets promote expression of SOCS3, a protein that induces macrophages to adopt inflammatory characteristics. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Gill hopes genetically engineered macrophages can be the stowaways that sneak into solid tumor and attack from the inside out. Behind the Scenes of a Radical New Cancer Cure 2019-11-09T05:00:00Z But when the scientists cracked open the macrophages, they found they were mistaken. How safe is vaping? New human studies assess chronic harm to heart and lungs 2019-11-26T05:00:00Z Erythrocytes live up to 120 days in the circulation, after which the worn-out cells are removed by a type of myeloid phagocytic cell called a macrophage, located primarily within the bone marrow, liver, and spleen. Anatomy and Physiology 2013-06-19T00:00:00Z Natural killer cells are not always present in the body and must be induced, whereas macrophages are constantly present. Biology for AP Courses 2022-06-09T00:00:00Z The authors next investigated the factors that govern the switch in macrophage function. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Tumours that are responsive to immunotherapy are associated with the presence of activated immune cells called macrophages that express the protein iNOS6. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z It is marked by lipid found in lung tissue and also in cells called macrophages, which normally sweep up debris in the lungs. Scientists chase cause of mysterious vaping illness as death toll rises 2019-10-10T04:00:00Z At the end of their lifecycle, they are destroyed by macrophages, and their components are recycled. Anatomy and Physiology 2013-06-19T00:00:00Z Natural killer cells actually kill foreign cells, whereas macrophages serve only a signaling function. Biology for AP Courses 2022-06-09T00:00:00Z For instance, it is unclear precisely how platelets foster monocyte recruitment and how they reprogram macrophages. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z CD4 helper T cells alone are not sufficient to drive this iNOS expression in macrophages, and CD8 T cells are also required, suggesting an interplay between these three types of cell. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z Her team found lipids accumulating in the lung macrophages of mice exposed to e-cigarettes. Scientists chase cause of mysterious vaping illness as death toll rises 2019-10-10T04:00:00Z An MI often occurs when a coronary artery is blocked by the buildup of atherosclerotic plaque consisting of lipids, cholesterol and fatty acids, and white blood cells, primarily macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z Only macrophages can invade host tissues to fight foreign cells that make their way into those tissues. Biology for AP Courses 2022-06-09T00:00:00Z In addition, it would be valuable to visualize the aggregates in vivo, perhaps using electron microscopy, to obtain a clear picture of what a macrophage–platelet aggregate really looks like. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Consistent with these findings, previous work7 indicates that macrophage activation triggered by IFN-γ from CD4 T cells leads to the inhibition of tumour growth. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z In the report, doctors wrote that “foamy macrophages and pneumocyte vacuolization were seen in all cases.” Chemical burns from vaping? Lung damage resembles mustard gas exposure, Mayo Clinic doctors say 2019-10-04T04:00:00Z The red pulp consists of reticular fibers with fixed macrophages attached, free macrophages, and all of the other cells typical of the blood, including some lymphocytes. Anatomy and Physiology 2013-06-19T00:00:00Z Natural killer cells kill foreign cells through the processes of lysis and proteolysis, whereas macrophages kill foreign cells by phagocytosis. Biology for AP Courses 2022-06-09T00:00:00Z Finally, future work will need to determine whether this phenomenon occurs broadly in other situations involving monocyte recruitment and consequent macrophage activity, for instance in infected or injured tissue. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Antigen-presenting immune cells, such as macrophages or dendritic cells, that capture material from dead tumour cells and present it on type II MHC molecules are probably involved. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z Clinicians at the University of Utah also found the same type of cells, known as lipid-laden macrophages, in the lungs of six patients. Vaping lung injuries top 1,000 cases as deaths rise to 18 2019-10-03T04:00:00Z The white pulp surrounds a central arteriole and consists of germinal centers of dividing B cells surrounded by T cells and accessory cells, including macrophages and dendritic cells. Anatomy and Physiology 2013-06-19T00:00:00Z The macrophages in the recipient will identify the MHC I molecules on transplanted organ as non-self proteins, causing lysis of transplanted cells. Biology for AP Courses 2022-06-09T00:00:00Z Nevertheless, the study builds on a long line of work implicating platelets, monocytes and macrophages as key contributors to atherosclerosis. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Researchers from Utah last month reported finding macrophages—a type of immune cell—filled with lipids in the cases they reviewed, but that other symptoms were not consistent with lipoid pneumonia. Vaping-Related Lung Injuries Resemble Chemical Burns 2019-10-03T04:00:00Z Instead, they saw many immune cells called macrophages with what he described as “the fine, foamy-looking appearance that is characteristic of chemical injuries.” Lung damage from vaping resembles chemical burns, report says 2019-10-02T04:00:00Z Following an early neutrophil infiltrate stimulated by macrophage cytokines, more macrophages are recruited to clean up the debris left over at the site. Anatomy and Physiology 2013-06-19T00:00:00Z After an infection has passed, tissue must be repaired, and macrophages and phagocytes remain active in the affected tissue, often leading to chronic inflammation. Biology for AP Courses 2022-06-09T00:00:00Z The conceptual power of exploring how immune and blood-clotting pathways intersect, the insights into monocyte and macrophage function, and the corroborating human data, are all worthy of further exploration. Platelets have a dangerous hold over immune cells in cardiovascular disease 2019-12-08T05:00:00Z Larsen, of Mayo Clinic Arizona, said the team found some signs of lipids in macrophages, though not large amounts. Vaping-Related Lung Injuries Resemble Chemical Burns 2019-10-03T04:00:00Z These large cells, called macrophages, are the cleanup crew of the immune system. What we know so far about the US vaping illness outbreak 2019-09-10T04:00:00Z Th1 cells are a type of helper T cell that secretes cytokines that regulate the immunological activity and development of a variety of cells, including macrophages and other types of T cells. Anatomy and Physiology 2013-06-19T00:00:00Z A good example of this occurs in a group of white blood cells called macrophages, which are part of your body’s immune system. Biology for AP Courses 2022-06-09T00:00:00Z The immune system’s myeloid cells — a group that includes macrophages and monocytes — are exposed to a range of physical forces, for example those encountered when leaving blood vessels to enter tissues6. Pressure regulates immune-cell function 2019-08-20T04:00:00Z However, little is known about the relative contribution of the two lineages of macrophages to the development and function of joints in health and disease. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z The researchers found that after a stroke, TREM1 levels on the surfaces of myeloid cells called macrophages also rose, exposing the body and brain to yet more inflammation. New Method for Tackling Stroke Restrains an Overactive Immune System 2019-07-02T04:00:00Z Bacteria such as Mycobacterium leprae, the cause of leprosy, are resistant to lysosomal enzymes and can persist in macrophage organelles or escape into the cytosol. Anatomy and Physiology 2013-06-19T00:00:00Z In the production of mammalian red blood cells, erythrocytes that have not yet matured and are still synthesizing heme proteins are surrounded by a macrophage. Biology for AP Courses 2022-06-09T00:00:00Z The reduced inflammation was accompanied by a decrease in immune cells such as neutrophils, monocytes and macrophages, which are major drivers of inflammation. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z To add to the complexity, macrophages exist as various subsets, some of which are pro-inflammatory, whereas others are anti-inflammatory and aid tissue repair5. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z As a result, the macrophages release signals that lead to scar tissue. This injectable gel could one day rebuild muscle, skin, and fat 2019-05-01T04:00:00Z In such situations, infected macrophages receiving cytokine signals from Th1 cells turn on special metabolic pathways. Anatomy and Physiology 2013-06-19T00:00:00Z Predict the role of the macrophage in the maturation of a red blood cell. Biology for AP Courses 2022-06-09T00:00:00Z Their tumors grew faster than in mice that didn't get the drug, and as in the patients, were swarmed with macrophages, suggesting the checkpoint inhibitor switched the cells into an immune-suppressing mode that favors tumors. New drugs that unleash the immune system on cancers may backfire, fueling tumor growth 2019-03-28T04:00:00Z To study macrophages, the authors began by focusing on a protein called CX3CR1, which is expressed on monocytes and macrophages. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z In nerves excised from men experiencing pain, Price’s team found signs of inflammation caused by an immune cell called a macrophage. Why the sexes don’t feel pain the same way 2019-03-26T04:00:00Z Macrophage oxidative metabolism is hostile to intracellular bacteria, often relying on the production of nitric oxide to kill the bacteria inside the macrophage. Anatomy and Physiology 2013-06-19T00:00:00Z This pain is often accompanied by sterile inflammation with components of the innate immune system such as macrophages. Biology for AP Courses 2022-06-09T00:00:00Z Rituximab needs immune cells called macrophages to step in and assist in B cell destruction. Genetically engineered immune cells wipe out lupus in mice 2019-03-06T05:00:00Z The authors discovered that certain macrophages form a cell layer that protects joints from the inflammatory immune-cell attacks on bone and cartilage that are associated with arthritis. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z Mature neutrophils and monocytes migrate to arterial walls, where the monocytes develop into macrophage cells. How broken sleep promotes cardiovascular disease 2019-02-12T05:00:00Z Cytokines are glycoproteins secreted by a wide variety of cells, including red bone marrow, leukocytes, macrophages, fibroblasts, and endothelial cells. Anatomy and Physiology 2013-06-19T00:00:00Z Or macrophages, the cleanup crew of the bloodstream? How deaf researchers are reinventing science communication 2018-12-11T05:00:00Z Cells such as macrophages that devour invaders are a key part of vertebrate defenses. This strange marine creature has an immune system remarkably similar to ours 2018-12-05T05:00:00Z When arthritis was induced, the layer underwent active remodelling that loosened the physical interactions between barrier macrophages and lining-layer fibroblasts. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z In separate experiments, the team confirmed that T cells, macrophages and natural killer cells all contribute to the drug’s benefit. The Biology of Sugars Points to a Sweet Strategy for Treating Cancer 2018-11-28T05:00:00Z When they arrive, they are often given distinct names, such as macrophage or microglia, depending on their function. Anatomy and Physiology 2013-06-19T00:00:00Z In 2017, he and his colleagues showed that macrophages, immune cells that are a key orchestrator of inflammation that is typically associated with scarring, are also required for regenerative healing in spiny mice6. Unlocking the secrets of scar-free skin healing 2018-11-20T05:00:00Z But scientists are also trying to open a whole new avenue of immunotherapy, one that focuses not on T-cells, but on another part of the immune system, a white blood cell called a macrophage. How Can We Unleash the Immune System? 2018-11-20T05:00:00Z Cells of the latter group divide and differentiate to form either barrier macrophages, or interstitial macrophages that express Retnla. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z Another approach is to use therapies designed to block the over-proliferation of macrophages, which contribute to the fibrosis and inflammation seen in chronic GvHD. Solving lymphoma’s stem-cell problem 2018-11-13T05:00:00Z Agranular leukocytes include monocytes, which mature into macrophages that are phagocytic, and lymphocytes, which arise from the lymphoid stem cell line. Anatomy and Physiology 2013-06-19T00:00:00Z Now, the team is trying to determine which factors might tip macrophages and other immune cells away from scarring pathways and towards regeneration. Unlocking the secrets of scar-free skin healing 2018-11-20T05:00:00Z The malignant cells carry a protein that researchers call a “don’t eat me” signal, which shuts down the macrophages. How Can We Unleash the Immune System? 2018-11-20T05:00:00Z This suggests that cells similar to the barrier and interstitial macrophages in mice might also exist in humans, and thus be relevant to human disease. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z This aspect is also not clear for macrophages in the immune system. A ‘don’t eat me’ immune signal protects neuronal connections 2018-10-28T04:00:00Z Platelets remain only about 10 days, then are phagocytized by macrophages. Anatomy and Physiology 2013-06-19T00:00:00Z The immunotherapy drug pembrolizumab blocks this pathway, enabling macrophages to go on the offensive against the tumour. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z The researchers isolated macrophage cells, which are part of the body’s immune system and engulf harmful particles such as bacteria and air pollution. Air pollution particles found in mothers' placentas 2018-09-16T04:00:00Z It would be interesting to learn whether the population of barrier macrophages is restored in people whose rheumatoid arthritis is being successfully treated and is in remission. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z "Tumors acquire macrophages to support their own growth and turn them into their minions," Gill says. Engineered natural killer cells may be the next great cancer immunotherapy 2018-09-13T04:00:00Z Whereas macrophages act like sentries, always on guard against infection, neutrophils can be thought of as military reinforcements that are called into a battle to hasten the destruction of the enemy. Anatomy and Physiology 2013-06-19T00:00:00Z These were macrophages, the police vans of the immune system — whose job it is to capture invading bacteria, cart them off and destroy them. Her Searing Gut Pain Suggested Celiac. Why Didn’t Cutting Out Gluten Help? 2018-08-15T04:00:00Z They looked very like the sooty particles found in macrophages in the lung, which catch many – but not all – of the particles. Air pollution particles found in mothers' placentas 2018-09-16T04:00:00Z Culemann and colleagues’ work adds to studies3,4,9 showing that macrophages are exquisitely adapted to the functions they perform in the tissues in which they reside. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z The duo helped found a company, Carisma Therapeutics in Philadelphia, Pennsylvania, that expects to begin clinical trials of CAR macrophages next year. Engineered natural killer cells may be the next great cancer immunotherapy 2018-09-13T04:00:00Z A monocyte is a circulating precursor cell that differentiates into either a macrophage or dendritic cell, which can be rapidly attracted to areas of infection by signal molecules of inflammation. Anatomy and Physiology 2013-06-19T00:00:00Z When captured by macrophages, the bug somehow disarms the cells’ built-in mechanism for destroying their prey. Her Searing Gut Pain Suggested Celiac. Why Didn’t Cutting Out Gluten Help? 2018-08-15T04:00:00Z They found vapour caused inflammation and impaired the activity of alveolar macrophages, cells that remove potentially damaging dust particles, bacteria and allergens. E-cigarettes 'more harmful than we think' 2018-08-13T04:00:00Z Barrier macrophages join a growing list of types of macrophage that shield tissues from damage caused by infection, inflammation or cancer. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z T cells, for example, respond to the cellular debris left-over when a macrophage digests a tumor cell, so he envisions that patients would receive CAR macrophages along with CAR T cells. Engineered natural killer cells may be the next great cancer immunotherapy 2018-09-13T04:00:00Z Phagocytes such as macrophages have receptors for these proteins, and they are thus able to recognize them as they are bound to the bacteria. Anatomy and Physiology 2013-06-19T00:00:00Z To track newly made mitochondrial DNA, the authors introduced a labelled building block of DNA into macrophage cells grown in vitro. Newly made mitochondrial DNA drives inflammation 2018-07-24T04:00:00Z Parasites from the Leishmania genus live and replicate inside a membrane-bound vacuole in macrophage cells of the immune system. Drug candidate and target for leishmaniasis 2018-07-24T04:00:00Z The challenge that lies ahead will be to develop ways of specifically targeting subsets of macrophages and fibroblasts with the ultimate goal of developing new treatments for people with arthritis. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z Secondly, it prevents the tumour from telling macrophages to turn docile. Drug gets body cells to 'eat' cancer 2018-07-02T04:00:00Z In delayed hypersensitivity, the first exposure to an antigen is called sensitization, such that on re-exposure, a secondary cellular response results, secreting cytokines that recruit macrophages and other phagocytes to the site. Anatomy and Physiology 2013-06-19T00:00:00Z Our blood alone carries a rich assortment—from the flat, doughnut-shaped red blood cell to the more globular, foreign-particle-guzzling macrophage—one of the largest cells in the body. "Ghost" Cytometry May Improve Cancer Detection, Enable New Experiments 2018-06-14T04:00:00Z The authors optimized the compounds by assessing their effect on in vitro infection of macrophages by Leishmania and by testing them using a mouse model of visceral leishmaniasis. Drug candidate and target for leishmaniasis 2018-07-24T04:00:00Z First, they differentiated into immune cells called macrophages and traveled to the injured kidney tissues. Cells Talk and Help One Another via Tiny Tube Networks 2018-05-07T04:00:00Z The treatment boosts the action of white blood cells, called macrophages, that the immune system uses to gobble up unwanted invaders. Drug gets body cells to 'eat' cancer 2018-07-02T04:00:00Z Worn-out erythrocytes are phagocytized by macrophages and their hemoglobin is broken down. Anatomy and Physiology 2013-06-19T00:00:00Z Her keen interest in macrophages notwithstanding, Ehrenreich is hardly a disinterested messenger of this disturbing news. ‘Natural Causes’: Author takes on our notions of wellness, aging, death 2018-04-29T04:00:00Z It infects host immune cells called macrophages and resides in a membrane-bound vacuole. Drug candidate and target for leishmaniasis 2018-07-24T04:00:00Z Once there, the macrophages formed TNTs with injured cells and transferred lysosomes—tiny packages full of healthy enzymes—to the diseased cells, Cherqui explained. Cells Talk and Help One Another via Tiny Tube Networks 2018-05-07T04:00:00Z This latest work involves a devouring or "phagocytic" immune cell called the macrophage. Drug gets body cells to 'eat' cancer 2018-07-02T04:00:00Z A macrophage is an irregularly shaped phagocyte that is amoeboid in nature and is the most versatile of the phagocytes in the body. Anatomy and Physiology 2013-06-19T00:00:00Z For simplicity not all possible genotypes are represented. c, Percentage viability of macrophages from E13.5 fetal liver cell suspensions from embryos of the indicated genotypes. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis 2018-04-24T04:00:00Z Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Innate immune memory in the brain shapes neurological disease hallmarks 2018-04-10T04:00:00Z The diseased cells also sent their defective lysosomes back to the macrophages through the same channels. Cells Talk and Help One Another via Tiny Tube Networks 2018-05-07T04:00:00Z In their model of tattoo persistence, published Tuesday in the Journal of Experimental Medicine, macrophages — immune cells that ingest foreign or unhealthy debris in the body — play a starring role. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z They are called different names, depending on the tissue: Kupffer cells in the liver, histiocytes in connective tissue, and alveolar macrophages in the lungs. Anatomy and Physiology 2013-06-19T00:00:00Z Now, experiments with tattooed mice might explain why: immune cells called macrophages ‘recycle’ dark pigments, keeping the ink in place. Why that tattoo is yours for life 2018-03-05T05:00:00Z Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Innate immune memory in the brain shapes neurological disease hallmarks 2018-04-10T04:00:00Z Next they tattooed the animals’ tails with green fluorescent ink and examined sections of the tattooed skin under a microscope to confirm the ink particles are indeed taken up by the macrophages. Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z As a tattoo is given, macrophages descend to capture invading ink. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z The initial immune response involves cells of the body’s innate immune system, such as macrophages and neutrophils. How the flu hijacks your body to make you feel so wretched 2018-02-16T05:00:00Z As the cells died, they released the pigments, which were readily taken up by neighbouring macrophages. Why that tattoo is yours for life 2018-03-05T05:00:00Z Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Innate immune memory in the brain shapes neurological disease hallmarks 2018-04-10T04:00:00Z “The fact that macrophages hardly move within the skin explains why the tattoo is pretty stable,” Henri says. Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z Then, looking at tattoo biopsies under the microscope, scientists saw macrophages laden with ink globules, and the story of tattoos became one of the immune system. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z It is a live substance with live white cells, macrophages, immunological properties, etc in it. The Importance of Infants’ Exposure to Microorganisms 2018-02-05T05:00:00Z This pigment recycling probably helps tattoos to persist, the authors say, although they add that a few long-lived macrophages packed with pigments might contribute to tattoos’ permanence. Why that tattoo is yours for life 2018-03-05T05:00:00Z Routy speculates that the only other organ to have as many macrophages may be the lungs, where they have the important duty of filtering out dust and microbes. A Private Place Where HIV, Zika and Ebola Hide 2018-01-26T05:00:00Z Simon Yona, an immunologist at University College London who studies macrophages and was not involved in the new work, praised the way the researchers engineered their experimental animals. Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z Still, it was thought that tattoo-bearing macrophages were stable and long-lived, giving tattoos their permanence. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism 2018-01-21T05:00:00Z When Collins and his team added antibiotics to mouse immune cells called macrophages, the cells consumed less oxygen, necessary for bacteria-killing activity. A New Antibiotic Weakness--Drugs Themselves Help Bacteria Survive 2017-12-04T05:00:00Z With this approach, she says, “the pigment particle fragments generated by the laser pulses would not be immediately recaptured by macrophages—increasing the likelihood that they will drain away via the lymphatic vessels.” Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z What this study suggests is that, at least in mice, these macrophages are constantly being replaced. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z They knew from earlier work that macrophages, a particular type of immune cell, change shape depending on what they are doing. Faking cellular suicide could help control inflammation 2017-09-14T04:00:00Z Those proteins are made by macrophages — white blood cells programmed to attack infections and other foreign bodies. Tantalizing Clues Point to Inflammation's Role in an Array of Diseases 2017-09-01T04:00:00Z The researchers found that the Asian Zika virus strain caused the macrophages to become “M2 macrophages,” which are cells that signal that the body is healing and turn off immune system activation. Why Zika Is Especially Dangerous for Pregnant Women 2017-08-21T04:00:00Z A French research team found that blocking the immune system’s own macrophages—cells that identify and engulf cellular debris, microbes and other foreign bodies—would likely help erase tattoos’ permanence. Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z They were examining skin cells in black mice for another project when they noticed macrophages scavenging the melanin released by dying, pigment-making cells. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z They analysed 3.5 million cells for the expression of 29 proteins used to characterize macrophages, and 23 to characterize T cells. Cell maps reveal fresh details on how the immune system fights cancer 2017-05-03T04:00:00Z When stimulated, the T cells release another neurotransmitter, called acetylcholine, which then binds to macrophages in the spleen. The shock tactics set to shake up immunology 2017-05-02T04:00:00Z The African Zika virus caused similar increases in M2 macrophages, but the Asian strain caused significantly more. Why Zika Is Especially Dangerous for Pregnant Women 2017-08-21T04:00:00Z Follow-up experiments, described in the new paper, suggest macrophages may also play a role in absorbing particles of tattoo ink. Tats Off: Targeting the Immune System May Lead to Better Tattoo Removal 2018-03-06T05:00:00Z When the team began examining mice that lacked macrophages, a technician noticed that the electrical rhythms of the animals’ hearts were abnormal. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z It focused on two kinds of immune cell, T cells and macrophages. Cell maps reveal fresh details on how the immune system fights cancer 2017-05-03T04:00:00Z The researchers also showed a drug that blocks P2X7R reduces high levels of infiltrating kidney macrophages, a hallmark of diabetic kidney disease, in diabetic rats. Molecule link to diabetic kidney disease - BBC News 2017-04-19T04:00:00Z This molecule promotes cell proliferation and attracts immune cells called macrophages, which boost tumour growth. Cancer: Early tumour growth halted : Nature : Nature Research 2017-03-07T05:00:00Z If they’re too big, cells in the blood called macrophages gobble them up. Nanoparticles awaken immune cells to fight cancer 2017-01-05T05:00:00Z The researchers then discovered that macrophages were common in AV nodes from mouse and human hearts. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z The results showed that populations of those T cells and macrophages are more varied than previously thought. Cell maps reveal fresh details on how the immune system fights cancer 2017-05-03T04:00:00Z Researchers can infect these organoids with bacteria or fungi, and study how the intestinal cells interact with immune cells such as macrophages derived from the same IBD cell lines. Cell-based therapy: Cells on trial : Nature : Nature Research 2016-12-20T05:00:00Z Blocking macrophage recruitment prevented TICs from developing into tumours and caused the immune system to eliminate them rapidly. Cancer: Early tumour growth halted : Nature : Nature Research 2017-03-07T05:00:00Z But the therapeutic benefit was marginal because, within weeks of implantation, the alginate would usually begin to attract immune cells such as macrophages and neutrophils. Diabetes: Encapsulating the problem : Nature : Nature Research 2016-12-06T05:00:00Z Why the AV node needs assistance from macrophages, when the heart muscle cells it harbors conduct electrical impulses perfectly well, remains unclear, Nahrendorf says. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z From each sample, they isolated a type of immune cell called macrophages, which engulf and destroy bacteria, and grew these cells in a dish. Neanderthal DNA affects ethnic differences in immune response 2016-10-19T04:00:00Z The fat seems to reduce the number of inflammatory immune cells called macrophages in the plaques. Cardiovascular biology: 'Good' fat may cut heart disease : Nature : Nature Research 2016-10-04T04:00:00Z The team also discovered YAP activation and macrophage recruitment in a small sample of precancerous lesions from human livers, suggesting that similar mechanisms might be involved in some human cancers. Cancer: Early tumour growth halted : Nature : Nature Research 2017-03-07T05:00:00Z When these fatty deposits damage an artery wall, immune cells flock to the scene—notably macrophages, which gobble up dying and damaged cells all over the body. Experimental anticancer drug may tackle heart disease, too 2016-07-20T04:00:00Z If they do, researchers might be able to restore the heartbeat to normal by, for example, dosing macrophages with drugs that alter their behavior. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z Microglia, the macrophages of the central nervous system, display an altered morphology in germ-free mice — a phenotype that is, in part, due to a paucity of SCFAs48. The microbiome and innate immunity : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Palmitoleate also blocks a type of inflammation that is triggered by saturated fat in both mouse and human macrophages. Cardiovascular biology: 'Good' fat may cut heart disease : Nature : Nature Research 2016-10-04T04:00:00Z Obesity and insulin resistance are associated with the increased infiltration of macrophages into and the inflammation of adipose tissue96, 97. Diet-microbiota interactions as moderators of human metabolism : Nature : Nature Publishing Group 2016-07-05T04:00:00Z Soon, dying muscle cells and dying macrophages join a growing plaque on the artery wall. Experimental anticancer drug may tackle heart disease, too 2016-07-20T04:00:00Z Because of these interactions, macrophages made it easier for their muscular neighbors to fire, the group reports today in Cell. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z These in turn recruit macrophages, cells whose job it is to gobble up microbes or anything else that does not belong in the body. Mosquito spit helps viruses make us sick 2016-06-21T04:00:00Z Such tumors are protected by a coating of cells known as macrophages, which keep the immune system’s main assassins, the T-cells, from entering. At the Vatican, a Search for Cancer’s Miracle Cure 2016-05-20T04:00:00Z Lymph node macrophages provide a physical barrier against tumor spread. SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions | Science 2016-04-07T04:00:00Z CD47 is key to protecting red blood cells from macrophages, and red blood cells are particularly sensitive to the blocking effects of the antibody as they get older, Leeper says. Experimental anticancer drug may tackle heart disease, too 2016-07-20T04:00:00Z For scientists studying AV node biology, “this paper really puts macrophages on the map,” says molecular and developmental biologist Vincent Christoffels of the University of Amsterdam in the Netherlands. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z This shows that the virus actually uses the macrophages to replicate and disseminate quickly in the body, the authors write in Immunity today. Mosquito spit helps viruses make us sick 2016-06-21T04:00:00Z “It’s almost as if this layer of macrophages is the wall that separates the Greek soldiers from getting to Helen of Troy,” Mak said. At the Vatican, a Search for Cancer’s Miracle Cure 2016-05-20T04:00:00Z Lymph node macrophages provide a physical barrier against tumor spread. SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions | Science 2016-04-07T04:00:00Z Covert will use the Frontiers award to focus on macrophages, cells that scientists think are fundamental to understanding how the human immune system works. Philanthropist Paul Allen announces $100 million gift to expand ‘frontiers of bioscience’ 2016-03-23T04:00:00Z When the researchers grew macrophages and heart muscle cells together in culture dishes, they found that the two types of cells were connected physically and synchronized electrically. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z Using SFV labeled with a fluorescent dye, the researchers discovered that the macrophages are themselves infected by the virus and start spreading the disease further, like policemen joining a mob they are meant to control. Mosquito spit helps viruses make us sick 2016-06-21T04:00:00Z But in recent years researchers have come to understand that macrophages are able to assemble, within themselves, specialized platforms that pump out the dozens of molecules that promote inflammation. Medicine’s Burning Question 2015-11-30T05:00:00Z Curcumin may help the macrophages, which play an important role in our immune system, clear the amyloid plaques found in Alzheimer's disease. 3 Reasons to Include Turmeric in Your Diet 2015-07-24T04:00:00Z In the photograph on top, the proteins needed to assemble an inflammasome are scattered throughout the cytoplasm of an unstimulated macrophage. Inflammation Factories: Before and After 2015-06-22T04:00:00Z After spurring the animals’ hearts to beat faster with an electrical stimulus, the team used a fiber optic cable to illuminate the organ, thus prodding the macrophages. Immune cells unexpectedly help the heart keep its beat 2017-04-20T04:00:00Z Activated macrophages kill off invaders by releasing microbe-slaying molecules called reactive oxygen species, and the team thought high salt concentrations might trigger the immune cells to produce these compounds. Does high-salt diet combat infections? 2015-03-03T05:00:00Z The key white blood cell in inflammation is called a macrophage, and for decades it has been a subject of study in my hematology laboratory and in many others. Medicine’s Burning Question 2015-11-30T05:00:00Z When you tattoo your body, you are injecting ink deep into the dermis—and the macrophages recognize tattoo ink as “foreign” invaders. Tattoo Regret? A Topical Removal Cream May Help 2015-02-19T05:00:00Z The macrophage and monocyte categories are computed relative to microglia49, 50. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer/'s disease : Nature : Nature Publishing Group 2015-02-17T05:00:00Z It also brings the bugs in question to the notice of the body’s defences, such as white blood cells called macrophages, which then eat them. Making resistance futile 2014-11-20T05:00:00Z After 24 hours, the E. coli load in macrophages exposed to high sodium chloride levels was less than half of that of macrophages cultured without salt, and L. major infections were down as well. Does high-salt diet combat infections? 2015-03-03T05:00:00Z Recently, researchers have found macrophages in the pancreases of people with Type II diabetes. Medicine’s Burning Question 2015-11-30T05:00:00Z Some of these macrophages absorb the ink and then carry it to lymph nodes, where both cells and ink are destroyed. Tattoo Regret? A Topical Removal Cream May Help 2015-02-19T05:00:00Z The macrophage and monocyte categories are computed relative to microglia49, 50. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer/'s disease : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Sanofi, a French firm, is also working on an antibody that kills Staphylococcus by attracting it to the attention of macrophages. Making resistance futile 2014-11-20T05:00:00Z The team cultured macrophages from mice and sprinkled salt into the nutrient bath until the cells were growing in a sodium chloride concentration equivalent to what they’d seen in the rodents’ infected skin. Does high-salt diet combat infections? 2015-03-03T05:00:00Z The macrophages release inflammatory molecules that are thought to impair insulin activity. Medicine’s Burning Question 2015-11-30T05:00:00Z Other targets include monocytes and macrophages, types of white blood cells whose job is to absorb and clear away foreign organisms. How Ebola Blindsides the Body's Defenses 2014-11-07T05:00:00Z The Ebola virus is usually transmitted by close contact and the first cells it affects are cells important to your primary immune response—monocytes, macrophages and dendritic cells. When Will We Have a Vaccine for Ebola Virus? 2014-07-29T04:00:00Z Here, they showed that the virus was hiding in other infection-fighting white blood cells called monocytes and macrophages. Joep Lange, The Physician-Scientist Before The Medical Diplomat 2014-07-20T04:00:00Z Next, the team infected macrophages with the common pathogens Escherichia coli or Leishmania major. Does high-salt diet combat infections? 2015-03-03T05:00:00Z The infected red blood cells and their invaders then fall prey to immune-system cells, called macrophages, in the spleen, the body’s main blood filter. Has Malaria Met Its Match? 2014-05-23T04:00:00Z We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. [Report] The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal 2014-05-08T18:26:56.216Z Intravital imaging studies showed that macrophages, along with tumour cells and endothelial cells, form a structure that pumps tumour cells into the bloodstream — a key step in metastasis. Imaging: Cancer caught in the act 2014-05-07T17:20:20.854Z In particular, the macrophages could harbor HIV outside the blood, off in tissues. Joep Lange, The Physician-Scientist Before The Medical Diplomat 2014-07-20T04:00:00Z “It became B cells and T cells, and monocytes, and macrophages. And macrophages became dendritic cells, and T cells became regulatory T cells and killer T cells,” he says. Cell physiology: The changing colour of fat 2014-04-16T17:21:54.590Z "Normally, many human cells die in the body every day, and cells known as macrophages eat these dead cells," Petri said. Amoeba Takes Bites of Human Cells to Kill Them 2014-04-09T19:38:00Z Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal. [Report] The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal 2014-05-08T18:26:56.216Z In the lung, emboli cross into the alveolar space where they are degraded by macrophages, whereas in the kidney, they enter the renal tubules, constituting potential routes for permanent removal of circulating debris. [Research Articles] Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation 2014-03-05T19:25:27.845Z Enrichment analysis of consensus markers reinforced the primacy of peritoneal macrophage infiltration and activation, which was demonstrably elevated in ex vivo cultures. [Research Articles] Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation 2014-02-05T19:55:05.837Z As the cells start to die, macrophages swarm to the fat depots to try and clean up the mess by carrying away the lipid droplets. Cell physiology: The changing colour of fat 2014-04-16T17:21:54.590Z When macrophages eat cells, they usually release chemicals that dampen inflammation. Amoeba Takes Bites of Human Cells to Kill Them 2014-04-09T19:38:00Z Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. [Report] The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal 2014-05-08T18:26:56.216Z These were part of a nonreplicating population formed immediately after uptake by macrophages and were induced by vacuolar acidification and nutritional deprivation, conditions that also induce virulence gene expression. [Report] Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters 2014-01-09T18:57:01.406Z In particular, they believe that SSI molecules alter the activity of macrophages, a type of cell involved in the early stages of an immune response. Bacteriology: A caring culture 2013-12-18T18:50:53.896Z The problem is that the macrophages cannot clear up the lipids fast enough, and so they begin to spill over into other tissues, such as the liver and pancreas. Cell physiology: The changing colour of fat 2014-04-16T17:21:54.590Z It's also rich in alkaloids, which increase the immune response and activate macrophages, the type of immune cells that fight off viruses. 6 Natural Flu-Fighting Remedies 2013-12-13T04:06:00Z It might even be other immune cells, such as macrophages, that are responsible for transport. The bacteria in breast milk 2013-12-09T19:15:04.759Z In high-grade tumors, both tumor cells and tumor-associated macrophages exhibited high expression levels of the enzyme. [Report] 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology 2013-12-04T22:56:42.664Z The SSIs, they say, cause macrophages to shift from a response involved in tissue repair and cancer growth to a response that promotes the destruction of abnormal cells. Bacteriology: A caring culture 2013-12-18T18:50:53.896Z Meet Your Body’s Death Eaters–A fascinating guide to the different types of macrophages. Nerds and Words: Week 48 2013-12-01T23:15:02.720Z In our lungs macrophages scour the surface, mopping up the many foreign objects that land but don’t belong there. Accident of Evolution Allows Fungi to Thrive in Our Bodies 2013-11-23T14:15:00.387Z These tumor-associated macrophages also supply growth factors to cancer cells, to enable them to divide and grow; cancer cells reciprocally stimulate the macrophages by producing their favorite growth factor, known as Colony Stimulating Factor. The Hallmarks of Cancer 6: Tissue Invasion and Metastasis 2013-10-30T23:15:03.320Z Experimentally, cytotoxic chemotherapy or radiation treatment increased factors that mediate macrophage trafficking and intratumoral macrophages. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z A prominent pathological feature of PH is accumulation of macrophages near the arterioles of the lung. [Research Articles] Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension 2013-08-28T18:25:19.997Z The bacteria also invade macrophages, the immune system’s “attack cells,” which normally engulf and digest invading bacteria. Global Health: Bacteria Study Offers Clues to Typhoid Mary Mystery 2013-08-26T21:01:03Z If ingested, the fungal cells resist digestion while hiding from antibodies, T cells, and other immune system components, effectively converting a macrophage into a microbial Trojan horse. Accident of Evolution Allows Fungi to Thrive in Our Bodies 2013-11-23T14:15:00.387Z Before lesion development, we detected increased mRNA expression of chemokines in the skin associated with early infiltration of macrophages and mast cells and later infiltration of eosinophils, T cells, and neutrophils. [Research Articles] Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy 2013-08-21T18:25:05.013Z In breast cancer, assessment of pro- and antitumour immunity revealed that high macrophage content relative to cytotoxic T-cell content was correlated with a worse outcome than those with a low content. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway epithelial cells and macrophages. [Report] Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4 2013-08-15T17:57:45.670Z “We are able to look at infection directly inside macrophage cells, allowing us to screen a large number of chemical libraries more quickly,” says Pethe. Synthetic Molecule Chokes TB Growth 2013-08-05T10:15:00.637Z In susceptible people and animals species are just as skillful in duping macrophages as they are their soil attackers. Accident of Evolution Allows Fungi to Thrive in Our Bodies 2013-11-23T14:15:00.387Z Instead, he found that the beak’s magnetite is mostly in macrophages. Birds’ magnetic sense: Columbarian Columbuses 2013-07-11T14:58:09Z There are defense cells, things called macrophages, which will ingest bacteria and viruses. Is Age the Main Factor in Nelson Mandela's Lung Infection? 2013-06-27T17:15:09.217Z Today, many cancer patients are treated with antibody drugs that work in part by marking tumor cells for destruction by macrophages. Drug Combo Helps Immune System Fight Tumors 2013-05-30T19:00:00Z Immune cells, such as macrophages, dendritic cells, and T cells, are waiting in the blood vessels nearby to help. Wired and Wireless Components of the Brain 2013-03-14T17:15:00.450Z Finally, its exterior contains melanin, the same pigment that colors human skin, which both protects it from UV radiation as well as inhibits the digestive action of macrophages. Accident of Evolution Allows Fungi to Thrive in Our Bodies 2013-11-23T14:15:00.387Z But immune sentries called macrophages quickly spot foreign invaders and gobble them up. A Passport to Nanomedicine Success 2013-02-21T20:35:00Z Libby's lab and other research groups have also shown that inflammatory mediators can prompt macrophages in the plaque to churn out tissue factor, a protein that promotes clotting. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z Added to a petri dish of cancer cells and macrophages, the synthetic SIRPa proteins didn't do much—the macrophages still ignored the cancer cells. Drug Combo Helps Immune System Fight Tumors 2013-05-30T19:00:00Z Her team takes blood samples and extract macrophages, a part of the immune system which normally attacks foreign invaders. Trojan horse 'eliminates' cancer 2012-12-21T01:14:27Z Legionella pneumophila, the bacterial cause of Legionnaires' disease, lives symbiotically inside wild aquatic amoebas and similarly mistakenly infects human macrophages when victims inhale it. Accident of Evolution Allows Fungi to Thrive in Our Bodies 2013-11-23T14:15:00.387Z To avoid destruction by a wary immune system, nanoparticles must get past macrophages like the one shown here. A Passport to Nanomedicine Success 2013-02-21T20:35:00Z Researchers now suspect that the presence of macrophages results from a cascade of events. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z Known as CD47, it protects leukemia cells and other cancer cells from rampaging macrophages. Drug Combo Helps Immune System Fight Tumors 2013-05-30T19:00:00Z While using copper as a therapeutic strategy would be potentially dangerous for the host, targeting bacterial copper resistance may provide help for the macrophages and immune system cells to clear the bacteria naturally. Fighting bacteria with copper 2012-10-15T17:15:19.647Z Colonization of germ-free mice with Escherichia coli is sufficient to augment macrophage infiltration of adipose tissue and polarize macrophages towards the expression of pro-inflammatory cytokines. Functional interactions between the gut microbiota and host metabolism 2012-09-13T11:21:18.130Z In mice engineered so their macrophage cells would mimic those of people, expressing the human SIRPα protein, nanoparticles tagged with the CD47 peptide passports stuck around in the circulation rather than being gobbled up. A Passport to Nanomedicine Success 2013-02-21T20:35:00Z These newly recruited monocytes enter the arterial wall and mature into macrophages, which gorge on LDL cholesterol and balloon in size. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z As they divide to form tumors, they fly under the radar of macrophages, immune cells whose job it is to ingest dead cells and dangerous invaders. Drug Combo Helps Immune System Fight Tumors 2013-05-30T19:00:00Z Unlike neurons and other glial cells, they begin in the embryonic yolk sac as immune-cell progenitors, just as the macrophages that patrol the bloodstream for foreign invaders do. Microglia: The constant gardeners 2012-05-30T17:50:34.540Z As macrophages accumulate in adipose tissue, they change and secrete even more cytokines and other inflammatory factors into the bloodstream. Pathology: Cause and effect 2012-05-22T15:21:12.780Z As one of the immune system's primary defenders, macrophages work to eliminate objects they don't recognize as being part of the body. A Passport to Nanomedicine Success 2013-02-21T20:35:00Z In the 1980s, scientists found that plaque contains macrophages — immune cells that play a role in inflammation. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z His own group is working on an antibody that blocks the SIRPa receptor, which appears mainly on macrophages, as a way of preventing these immune cells from receiving the cancer cell's deceptive message. Drug Combo Helps Immune System Fight Tumors 2013-05-30T19:00:00Z Microglia are both the brain's resident macrophages and the only brain cells that express the complement receptor. Microglia: The constant gardeners 2012-05-30T17:50:34.540Z Alternatively activated or “M2” macrophages, are associated with a less destructive pattern of immune system activation. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z Their preferred home in amoebas may explain why they like invading our macrophages so much. Legionnaire's Disease at the Luxor: What Causes It? 2012-02-01T15:45:00.217Z The LDL in artery walls prompts endothelial cells, which line the vessels, to produce sticky molecules that snag macrophage precursor cells, monocytes, from the blood. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z In contrast, the ETP ALL signature showed significant positive enrichment of the gene expression profile of normal human haematopoietic stem cells and granulocyte macrophage precursors. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z If this does not kill the invader outright, then it acts as a flag for the bug in question to be eaten by a macrophage. Arthritis and botulinum toxin: Something to celebrate 2011-12-08T16:17:05Z At first the majority of the cells lodge within the lung, where they appear to interact with pulmonary macrophages altering the type of cell signaling molecules those macrophages release into the blood. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z Legionella bacteria get taken up by our macrophages and then parasitize them — and in turn us — just as they do wild amoebas. Legionnaire's Disease at the Luxor: What Causes It? 2012-02-01T15:45:00.217Z Hazen and colleagues found that the metabolite increases the number of receptors on the surface of macrophages that bind to LDL, which makes the cells more prone to gobble up cholesterol. Pathology: At the heart of the problem 2013-01-30T18:23:07.253Z In the body, HDL acts to remove cholesterol from specialized cells called macrophages, which helps to prevent the build-up of cholesterol in our blood vessels. Cholesterol and Controversy: Past, present, and future 2011-11-15T16:15:00.277Z Dr Chapman’s plan was to use this mechanism to get macrophages to eat toxin molecules. Arthritis and botulinum toxin: Something to celebrate 2011-12-08T16:17:05Z With “classic” macrophage activation, the immune response is aggressively induced. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z When cholesterol starts building up in arteries, scavenger white blood cells known as macrophages report to the scene to start trying to digest it. Specialized Immune Cells Fight Hardening Arteries 2011-11-10T18:45:00.490Z Immune cells, including macrophages and natural killer cells, also flood the lungs. Surprising Cells Rein In Killer Flu 2011-09-15T17:00:00Z Thus, we contend that Murphy’s assertion that deletion of β-catenin in macrophages is a caveat to our interpretation is unjustified. [Technical Response] Response to Comment on ?Activation of ?-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine? 2011-07-21T18:55:38.740Z Cells called macrophages summon all sorts of others to an injury, to try to repair it. Arthritis and botulinum toxin: Something to celebrate 2011-12-08T16:17:05Z Somehow stem cell infusion causes a change in the pattern of macrophage activation from M1 to M2, which results in a less aggressive immune response and less post-injury brain tissue death. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z In any case, the unintended deletion of β-catenin in macrophages in the present study would appear more complete that the intended depletion of DCs in their previous study. [Technical Comment] Comment on ?Activation of ?-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine? 2011-07-21T18:55:27.573Z This hypersensitivity was associated with the infiltration of neutrophils and macrophages into the dermis, and neutralizing the effects of CXCL5 attenuated the abnormal pain-like behavior. [Research Articles] CXCL5 Mediates UVB Irradiation-Induced Pain 2011-07-06T20:25:24.577Z Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine. [Technical Response] Response to Comment on ?Activation of ?-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine? 2011-07-21T18:55:38.740Z In particular, they seem to be too large to fall prey to macrophages, which are usually charged with consuming and killing harmful invaders. Super-Sized Spores Make Fungal Infections More Deadly, Possibly Explaining Victims in Missouri 2011-06-18T01:15:00.257Z In an early clinical study of human atheroma specimens from four patients, we found that ICG colocalized with plaque macrophages and lipids. [Research Articles] Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques 2011-05-25T20:55:17.057Z The deletion of other cells, such as CD11bCD11c– macrophages, was not analyzed. [Technical Comment] Comment on ?Activation of ?-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine? 2011-07-21T18:55:27.573Z Now that researchers understand how the drug worked, they are working on ways to boost the macrophage response, Vonderheide said. Pfizer Drug Slows Pancreatic Tumors in New Attack on Cancer 2011-03-24T18:35:02Z Instead, the attackers were macrophages, a more general kind of defensive cell whose jobs include munching bacterial invaders and helping to heal injured tissue. Good News About a Very Bad Cancer 2011-03-24T19:01:00Z Instead, these large fungal spores overpower the macrophages and kill them, making the body more vulnerable to further infection. Super-Sized Spores Make Fungal Infections More Deadly, Possibly Explaining Victims in Missouri 2011-06-18T01:15:00.257Z In this study, scientists from Imperial College in London found that a protein called IRF5 acts as a molecular switch that controls whether certain white blood cells, known as macrophages, will promote or inhibit inflammation. Scientists find inflammation immune cell switch 2011-01-16T18:03:15Z On the basis of additional in vitro co-culture analysis, the authors concluded it was macrophages that regulated tolerance. [Technical Comment] Comment on ?Activation of ?-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine? 2011-07-21T18:55:27.573Z Designed to activate immune system T-cells to attack the tumor, tests revealed the Pfizer drug instead spurred an abundance of white blood cells, called macrophages. Pfizer Drug Slows Pancreatic Tumors in New Attack on Cancer 2011-03-24T18:35:02Z In 2003 researchers at Columbia University and at Millennium Pharmaceuticals discovered hoards of macrophages, immune cells whose primary role is to engulf pathogens, in the fat stores of people with type 2 diabetes. Does Inflammation Trigger Insulin Resistance and Diabetes? 2011-01-05T22:15:44.607Z The dogma in the field was that the bacterium infected only immune cells called macrophages, says study leader Anne O’Garra, also of the MRC National Institute for Medical Research. Gene Profiles May Predict TB Prognosis 2010-08-19T15:49:00Z Scans on mice with blocked arteries showed these HDL-linked gold nanoparticles ended up in deposits of plaque that were also full of immune cells called macrophages. Gold in scan finds dangerous artery clogs: U.S. study 2010-08-16T22:39:00Z The other form of amoeboid cell, which Metschnikoff calls the macrophage, has more feeble phagocytic action towards bacteria, and these are rarely found enclosed within them. Disease and Its Causes Menstruation and those hungry janitor cells called macrophages that were responsible for dead cell removal would cleanse her of such things in the course of time. Tokyo to Tijuana: Gabriele Departing America Both HDL and macrophages help clear the blood of globs of harmful cholesterol, called LDL or low density lipoprotein. Gold in scan finds dangerous artery clogs: U.S. study 2010-08-16T22:39:00Z These deposits of overfed macrophages harden and are the main cause of artery clogging plaque. Gold in scan finds dangerous artery clogs: U.S. study 2010-08-16T22:39:00Z |
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