| 单词 | LDL |
| 例句 | The data point to increasing benefits with lower and lower LDL levels, said Dr. Daniel J. Rader. The Sense of Style 2014-09-04T00:00:00Z There is nothing unusual about coconut oil in this respect – all saturated fats raise both good HDL and bad LDL cholesterol levels. Coconut oil: are the health benefits a big fat lie? 2017-07-09T04:00:00Z Olive oil, we were told then, is good for you because it’s primarily a monounsaturated fat, consumption of which reduces dangerous LDL chocolesterol and maintains or even boosts HDL, the “good” cholesterol. Freshly pressed olive oil is magical. I know because I make it every year. 2017-02-10T05:00:00Z The same analysis found it also raised harmful LDL cholesterol. Coconut oil: are the health benefits a big fat lie? 2017-07-09T04:00:00Z Too much of it causes the liver to overproduce “bad” LDL cholesterol, which is implicated in heart disease. Butter nonsense: the rise of the cholesterol deniers 2018-10-30T04:00:00Z An additional way to significantly reduce your total cholesterol and LDL cholesterol levels through diet is by eating more soluble fiber. How can I lower my cholesterol? Do supplements work? How about psyllium or probiotics? 2023-10-03T04:00:00Z The bad one, LDL, travels through our arteries leaving a trail of plaque that damages, and ultimately blocks blood flow. How high-cholesterol foods can ruin your sex life 2017-07-16T04:00:00Z Doctors currently use drugs to try to get patients' LDL down to a specific target--for most people the target is 120 milligrams per deciliter. 2010-02-04T01:00:00Z The concern over dairy stems from the recognition that saturated fat raises LDL cholesterol levels which are linked to heart disease. Dairy in moderation is good for heart health, study finds 2018-09-11T04:00:00Z High levels of LDL cholesterol in the blood can lead to the build-up of plaque in arteries, which leads to an increased risk of heart disease and stroke. How can I lower my cholesterol? Do supplements work? How about psyllium or probiotics? 2023-10-03T04:00:00Z In June, the American Heart Association suggested that the coconut oil beloved as a panacea by clean eaters actually had “no known offsetting favourable effects”, and that consuming it could result in higher LDL cholesterol. Why we fell for clean eating 2017-08-11T04:00:00Z If you’ve been diagnosed with high triglycerides, high LDL cholesterol, or low HDL cholesterol, those are signs that you may be insulin resistant and may want to consider lifestyle changes. Perspective | Explaining insulin resistance, and how to reverse it 2021-10-25T04:00:00Z Banks cultivated plausible deniability, their internal oversight systems too feeble to pin responsibility on any individual; Goldman executives used the abbreviation LDL — “let’s discuss live” — to hide their traces. America’s Top Prosecutors Used to Go After Top Executives. What Changed? 2017-07-05T04:00:00Z That means that habitual consumers of artificial sweetener had more of the low-density lipoprotein, or LDL version, in their system. WHO’s recommendation against the use of artificial sweeteners for weight loss raises many questions 2023-06-08T04:00:00Z That's especially important if your doctor is concerned about glucose or LDL/HDL ratios. False-Alarm Medical Tests 2010-06-23T17:40:00Z It’s very dispiriting when people call each other vile names because they disagree about meat’s impact on LDL cholesterol. Perspective | Why making your diet part of your identity is bad for your health — and society 2020-09-23T04:00:00Z LDL does this by reducing the artery’s response to the hormone, which in turn decreases blood flow. How high-cholesterol foods can ruin your sex life 2017-07-16T04:00:00Z He cites a cardiologist in the 1980s, Prof Michael Oliver, who was a sceptic of the cholesterol hypothesis that more LDL increased the risk of heart attacks and strokes. Butter nonsense: the rise of the cholesterol deniers 2018-10-30T04:00:00Z "Some theorize that the increased LDL levels are at least in part explained by rapid weight loss causing cholesterol to be mobilized as fat cells shrink." National Keto Day: Here's what you should know before you try the diet 2022-01-05T05:00:00Z High amounts of LDL also increases one's risk of developing heart disease and stroke. The FDA is attempting to ban partially hydrogenated oils for good. But what in the world are they? 2023-08-16T04:00:00Z PCSK9 is made in the liver and blocks LDL receptor molecules on cells that allow the body to get rid of harmful cholesterol. Cholestrol-lowering vaccine jab to stop heart attacks could be close 2017-06-20T04:00:00Z "According to a study published in the journal Circulation in January 2020, coconut oil may enhance your LDL cholesterol levels, which is bad news for your heart." These are the worst cooking oils for your health, experts say 2022-03-19T04:00:00Z This LDL cholesterol can build up in the walls of arteries and form plaques, leading to arteries hardening over time and increasing the risk of heart attack and stroke. Coronation Quiche is outrageously expensive to make. Here are cheaper and healthier options 2023-04-20T04:00:00Z Most people know that in the realm of cooking fats, olive oil is considered a "good fat" because it is high in monounsaturated fatty acids, which can aid in lowering ones LDL cholesterol. New research shows olive oil could help reduce dementia-related deaths 2023-07-28T04:00:00Z In powder form, it’s used in beauty products and to lower LDL cholesterol for those with coronary heart disease. Perspective | Hints From Heloise: Do these oats take a powder? 2018-12-26T05:00:00Z LDL paired with triglycerides, a type of fat that the body uses for energy, can further increase the risks. “Keto-like” diets may increase your risk of heart disease, according to new research 2023-03-12T05:00:00Z FH patients still make some LDL receptors, and Verve’s strategy is to keep those molecules around for longer by altering the liver’s gene for PCSK9, an enzyme that normally removes the receptors from cells. Base editing, a new form of gene therapy, sharply lowers bad cholesterol in clinical trial 2023-11-11T05:00:00Z Dr. Rader said Ms. Elkins’s LDL level could put her at risk for a heart attack — but probably not for at least a couple of decades. A New Genetic Test Takes Aim at Young Hearts 2023-05-30T04:00:00Z Bad cholesterol, known LDL, can cause a buildup of plaque in blood vessels and increase the risk of heart disease and stroke. U.S. Supreme Court rules against Amgen bid to revive cholesterol drug patents 2023-05-18T04:00:00Z But the heart association’s report noted that these improvements tend to be short-lasting, and that very-low-carb diets often cause an increase in LDL cholesterol levels, which can heighten the risk of heart disease. Popular keto and paleo diets aren’t helping your heart, report says 2023-04-27T04:00:00Z Because I take a statin, I have low total cholesterol and LDL levels. Generic Adderall disappoints person with ADHD 2023-03-29T04:00:00Z This is roughly comparable to the drop in LDL in patients given relatively new, injected PCSK9-blocking drugs, which some patients now take instead of statins. Base editing, a new form of gene therapy, sharply lowers bad cholesterol in clinical trial 2023-11-11T05:00:00Z Ms. Thompson, in her late 40s, has an LDL cholesterol level of 160 milligrams per deciliter, not high enough to make a statin imperative. A New Genetic Test Takes Aim at Young Hearts 2023-05-30T04:00:00Z This drug does lower both total cholesterol and LDL cholesterol. How good is Nexletol against heart attacks? 2023-03-22T04:00:00Z Elevated levels of LDL cholesterol in your blood can lead to a buildup in your arteries, which in turn can lead to blood clots, heart attacks, and strokes. Do you need to shun sugar to lower cholesterol? 2023-03-20T04:00:00Z They can infiltrate the lining of blood vessels and usher in LDL cholesterol particles, thus contributing to atherosclerosis. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z Guasch-Ferré recommended using olive oil as a replacement for less healthy fat sources — especially butter and full-fat dairy products, which contain saturated fats that can raise your LDL levels. Does your latte need a shot of olive oil? 2023-03-06T05:00:00Z Ms. Elkins’s primary care doctor ordered a blood test, which revealed that her LDL cholesterol level was 160. A New Genetic Test Takes Aim at Young Hearts 2023-05-30T04:00:00Z Too much so-called LDL or “bad” cholesterol can clog arteries and lead to heart attacks and strokes. Can’t take statins? New pill cuts cholesterol, heart attacks 2023-03-04T05:00:00Z HDL helps prevent a buildup of LDL cholesterol, which is why it’s often referred to as “good” cholesterol. Do you need to shun sugar to lower cholesterol? 2023-03-20T04:00:00Z The traditional factors for assessing this risk include age, sex, whether the patient smokes or has diabetes, and lab measurements of lipids such as LDL cholesterol. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z Olive oil contains monounsaturated fatty acids, which can reduce levels of low-density lipoprotein, or LDL — sometimes called “bad” cholesterol — in your blood, according to the American Heart Association. Does your latte need a shot of olive oil? 2023-03-06T05:00:00Z In older people, the cumulative effect of traditional risk factors — like smoking, LDL levels and diabetes — were so powerful that they dominated the risk picture. A New Genetic Test Takes Aim at Young Hearts 2023-05-30T04:00:00Z Statin pills like Lipitor and Crestor – or their cheap generic equivalents – are the mainstay for lowering LDL cholesterol and preventing heart disease or treating those who already have it. Can’t take statins? New pill cuts cholesterol, heart attacks 2023-03-04T05:00:00Z Research has found that consuming too much dietary sugar can lower levels of HDL cholesterol and increase levels of LDL cholesterol and triglycerides. Do you need to shun sugar to lower cholesterol? 2023-03-20T04:00:00Z In contrast, LDL cholesterol provided no insight—it was higher in the people who didn’t have heart attacks, the scientists reported. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z High amounts of LDL can build up in the inner walls of the blood vessels, forming thick deposits called plaques that can narrow and clog major arteries; monounsaturated fats may help stave off this damage. Does your latte need a shot of olive oil? 2023-03-06T05:00:00Z Millions of Americans who are at high risk for heart attacks and whose LDL cholesterol levels are disturbingly high have been told over and over again by their doctors to take a statin. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z Q: My LDL cholesterol is a bit high, but I’d rather not take a statin. Will bergamot lower cholesterol and triglycerides? 2023-01-25T05:00:00Z According to a 2016 research review, as sugar intake increases, LDL cholesterol levels go up, whereas HDL cholesterol levels go down. Do you need to shun sugar to lower cholesterol? 2023-03-20T04:00:00Z Her other lipids, including LDL cholesterol and total cholesterol, also improved. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z “We found that the saturated fat in cheese did not raise LDL cholesterol levels to the same degree as butter did,” she says. Good news about cheese — it’s much healthier than you thought 2023-01-02T05:00:00Z The drug, bempedoic acid, is not new; the Food and Drug Administration approved it three years ago because it lowers LDL levels. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z Can you tell me how effective bergamot is for lowering LDL cholesterol and triglycerides? Will bergamot lower cholesterol and triglycerides? 2023-01-25T05:00:00Z The authors of a 2020 review of randomized controlled trials suggested that replacing fructose or sucrose with starch — a complex carbohydrate made up of glucose — may lower LDL cholesterol levels. Do you need to shun sugar to lower cholesterol? 2023-03-20T04:00:00Z Long overlooked, they are emerging as powerful alternatives to standard markers of heart disease risk such as LDL cholesterol. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z Those proportions matter, because while monounsaturated and polyunsaturated fats have been linked to a lower risk of obesity, cardiovascular disease and stroke, saturated fats have been shown to raise blood levels of LDL “bad” cholesterol. Which cooking oils are the healthiest? 2022-11-21T05:00:00Z Cardiologists generally say such patients should get their LDL below 70. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z The two drugs, which lower "bad" LDL cholesterol by blocking a protein called PCSK9 that prevents its removal from the blood, can reduce the risk of heart attacks and strokes in people with heart disease. U.S. Supreme Court to hear Amgen bid to revive cholesterol drug patents 2022-11-04T04:00:00Z Because healthful plant-based eating patterns contain a wealth of beneficial elements including fiber, heart-healthy fats, antioxidants, potassium and other nutrients, even being semi-vegetarian can decrease LDL cholesterol by 10%-15%. Eating plant-based for health isn’t an all-or-nothing deal 2022-10-17T04:00:00Z In addition to lowering triglycerides, it also can reduce total and LDL cholesterol and raise “good” HDL cholesterol. Extra benefits from fenofibrate 2022-09-28T04:00:00Z In the human genetic disease familial hypercholesterolemia, the LDL receptors are defective or missing entirely. Biology for AP Courses 2022-06-09T00:00:00Z Bempedoic acid reduced LDL levels by about 20 percent, not enough to get patients to the goal level. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z My total cholesterol is 132, LDL is 58 and good HDL is 51. Cardiologist complains about critical drug shortage 2022-05-18T04:00:00Z Cardiologists have known for almost 60 years that this blood lipid is probably as dangerous as LDL cholesterol. What happened to the flu this year? 2022-02-23T05:00:00Z “Focusing just on LDL is an oversimplification of a very complex disease process,” he says. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z People with this condition have life-threatening levels of cholesterol in their blood, because their cells cannot clear LDL particles from their blood. Biology for AP Courses 2022-06-09T00:00:00Z At the end of the study, the average LDL level in those taking the drug was 107, compared with 136 in the patients taking a placebo. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z Immune cells called T cells also become activated by pieces of degraded LDL, and can contribute to triggering a heart attack. Inflammation in Heart Disease: Do Researchers Know Enough? 2021-12-01T05:00:00Z Current research has also found no differences in lowering total cholesterol, “bad” LDL cholesterol, triglycerides, blood pressure, blood sugar or A1c. What to know if you’re considering intermittent fasting 2021-11-29T05:00:00Z His experiments analysing the blood plasma of people who had had a heart attack found big increases in the levels of LDL, whereas HDL levels were lower than normal. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z Gamma-tocopherol has been shown to inhibit oxidation of bad LDL cholesterol — important, because oxidized LDL contributes to inflammation in the arteries and is a risk factor for cardiovascular disease. Here are 5 delicious, nutritious foods to build your plate around this Thanksgiving 2021-11-22T05:00:00Z In contrast, statins can reduce LDL levels by as much as 50 percent. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z LDL, or “bad” cholesterol, is a major risk factor for coronary heart disease. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z It revealed that pistachio-enriched diets can lower triglycerides, LDL and total cholesterol. Here’s how many pistachios you need to eat to lower triglycerides 2021-09-22T04:00:00Z As evidence, she points to studies of people with familial hypercholesterolemia—a condition that arises from a mutation in the gene encoding the LDL receptor protein. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z It turns off, or silences, a gene called PCSK9, which results in the liver absorbing more "bad" LDL cholesterol from the blood and breaking it down. Life-saving cholesterol jab recommended on NHS 2021-08-31T04:00:00Z They have varying effects on LDL and range from cheap to expensive. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z Now a new study suggests that, like smoking, it has a cumulative effect over a lifetime: The longer a person has high LDL, the greater their risk of suffering a heart attack or cardiac arrest. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z We saw both statistically and clinically significant drops in LDL cholesterol, which is the bad cholesterol. The ‘Hedonistic Altruism’ of Plant-Based Meat 2021-08-27T04:00:00Z As a result, people with familial hypercholesterolemia have abnormally high levels of LDL cholesterol and, if left untreated, are up to 13 times more likely to develop coronary heart disease than someone without the mutation. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z “The two together are synergistically bad for raising LDL cholesterol.” Eating too many eggs can still be risky, but most people don’t have to give them up entirely, experts say 2021-07-30T04:00:00Z With this array of drugs, Dr. Davidson said he hoped doctors could start focusing on getting high-risk patients’ LDL levels as low as possible, whatever it takes. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z Using data from four large prospective health studies, researchers calculated LDL levels over time in 18,288 people who had multiple LDL tests taken at different ages. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z The avocado diet lowered oxidated LDL better than the other diets and reduced small, dense LDL particles. Celery seed for gout does the job, says this reader 2021-03-10T05:00:00Z The advent of statins—medication that lowers LDL by inhibiting a cholesterol-producing enzyme in the liver—reinforced the view that LDL cholesterol has a substantial role in heart disease. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z My total cholesterol is down to 165, and my LDL is now 83. Cocoa helped overpower constipation following surgery 2021-01-27T05:00:00Z Dr. Benjamin Ansell, a lipid expert at U.C.L.A., said that the drug was “better than nothing” but that “it isn’t enough” for people who have high LDL levels and are at high risk. A Statin Alternative Joins Drugs That Can Reduce Heart Attack Risk 2023-03-04T05:00:00Z They calculated their cumulative exposure to LDL and followed their health for an average of 16 years. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z Studies from Cuba in the 1990s and early 2000s reported drops in LDL, or bad, cholesterol, while nutrition researchers elsewhere failed to replicate those findings. Colombians Ask: Who Would Dare Patent Panela? 2021-01-26T05:00:00Z In gold-standard randomized controlled trials, people replace saturated fats in their diets with polyunsaturated fatty acids, such as those found in vegetable oil, and this reduces the levels of LDL cholesterol in the blood. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z Chylomicrons keep LDL cholesterol in circulation, giving it ample opportunity to get stuck in arteries. Does Coconut Oil Deserve Its Health Halo? 2021-01-04T05:00:00Z After gene editing, the monkeys’ LDL levels dropped by 59% within two weeks. A ‘cure for heart disease’? A single shot succeeds in monkeys 2020-06-27T04:00:00Z The researchers found that the longer a person had high levels of LDL — no matter what their LDL level is in young adulthood or middle age — the greater the risk for coronary heart disease. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z The president’s cholesterol was 167, with an LDL measurement of 91 and an HDL level of 70. Trump ‘Remains Healthy’ After Taking Hydroxychloroquine, His Doctor Says 2020-06-03T04:00:00Z He points out that research co-authored by Ravnskov found that people with the highest level of LDL cholesterol seem to live longer than those with the lowest levels9. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z The president takes Rosuvastatin to help lower his bad cholesterol, known as LDL, and to raise his good cholesterol, or HDL. Doctors kept close eye on Trump’s use of malaria drug 2020-06-03T04:00:00Z Watch your LDL cholesterol, a strong driver of heart disease, and eat a largely plant-based diet to help lower it if necessary. How ‘Fast Carbs’ May Undermine Your Health 2020-04-14T04:00:00Z They found no increased risk for stroke or heart failure associated with cumulative LDL exposure. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z Dr. Chazal said the LDL level presented by the White House constituted a 36 percent drop, which he said was a “good response” to the medication. Trump ‘Remains Healthy’ After Taking Hydroxychloroquine, His Doctor Says 2020-06-03T04:00:00Z And research in 2019 suggested that levels of a particular subclass of LDL might be a better predictor of heart attacks than is the total amount of LDL present10. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z In studies involving those patients, it reduced LDL cholesterol by 28 percent, the company said. FDA approves first non-statin pill to treat high cholesterol in almost two decades 2020-02-21T05:00:00Z High LDL, or bad cholesterol, is one of the top risks for heart attacks and other problems. FDA approves drug that lowers cholesterol in a new way 2020-02-21T05:00:00Z “Our figures suggest that the risk starts at LDL levels as low as 100,” said the lead author, YiYi Zhang, an assistant professor of medical sciences at Columbia. How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z The liver makes bile salts out of cholesterol, so as bile acids are broken down, the organ pulls more cholesterol out of the blood to replace them — lowering the levels of LDL in the blood. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z This protein usually removes LDL cholesterol from the blood, but in people with the condition it is faulty. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z Recommended cholesterol levels vary by age and gender, but the “optimal” level for LDL cholesterol is 100 milligrams per deciliter or below, according to the National Heart, Lung and Blood Institute. FDA approves first non-statin pill to treat high cholesterol in almost two decades 2020-02-21T05:00:00Z “What they wrote was that the ‘changes in LDL is not different,’ ” Barnard says. Cholesterol studies promoted the sunny side of eggs, but the research was hatched out of industry funding 2019-12-13T05:00:00Z “That doesn’t necessarily mean that a person under 40 with an LDL of 100 should immediately start treatment. We need more evidence to determine the optimal combination of age and LDL level.” How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z Or perhaps, as statins lower LDL levels, the gut is made more congenial for some bacteria and less so for others. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z In the early 1990s, the Scandinavian Simvastatin Survival Study showed that the statin simvastatin was effective at lowering LDL cholesterol and reducing the risk of a heart attack4. Is There More to a Healthy-Heart Diet Than Cholesterol? 2021-12-02T05:00:00Z Her cholesterol was in the healthy zone, with a total cholesterol of 193 and level of the so-called “bad” subtype, or LDL, at 88. Doctor’s report says Elizabeth Warren ‘in excellent health’ 2019-12-06T05:00:00Z “The correct way to report that is to say LDL rose a lot, 15 points, but we can’t rule out the small possibility of chance,” he said. Cholesterol studies promoted the sunny side of eggs, but the research was hatched out of industry funding 2019-12-13T05:00:00Z “The main message is to try to maintain low LDL through middle age. That will reduce your heart disease risk.” How Lifelong Cholesterol Levels Can Harm or Help Your Heart 2021-10-18T04:00:00Z In other words, the researchers determined that avocados may be able to lower oxidized LDL particles. An avocado a day could lower 'bad' cholesterol levels, study suggests 2019-10-29T04:00:00Z The soluble fiber in beans and oats, for example, may help to lower blood levels of artery-damaging LDL cholesterol. Fiber in Fruits and Grains Protects Against Diverticulitis 2019-10-28T04:00:00Z Trans fats, which are added to processed food in the form of partially hydrogenated vegetable oils, increase levels of LDL, or “bad” cholesterol. Trans Fats, Bad for the Heart, May Be Bad for the Brain as Well 2019-10-23T04:00:00Z This increased consumption was associated with a mean LDL cholesterol, what’s known as “bad” cholesterol, increase of 15 milligrams per deciliter of blood. Cholesterol studies promoted the sunny side of eggs, but the research was hatched out of industry funding 2019-12-13T05:00:00Z A phase III trial of the drug in people who had experienced a heart attack or stroke showed a roughly 50% decrease in LDL cholesterol levels. Why rare genetic diseases are a logical focus for RNA therapies 2019-10-15T04:00:00Z Liver cells also have a well-known and characterized receptor — the LDL receptor — that can be used to transport sufficient quantities of RNA into those cells. The challenge of delivering RNA-interference therapeutics to their target cells 2019-10-15T04:00:00Z “Reaching the LDL target is the most important thing,” she said. Statins May Affect Your Bone Health 2019-10-08T04:00:00Z Both drugs dramatically lower “bad” LDL cholesterol by blocking a protein known as PCSK9 that prevents LDL removal from the blood. U.S. judge rules for Regeneron, Sanofi in Amgen cholesterol drug... 2019-08-28T04:00:00Z Liebman says that cholesterol in foods does raise LDL, and eggs are the major source of cholesterol in the diet of most people. Cholesterol studies promoted the sunny side of eggs, but the research was hatched out of industry funding 2019-12-13T05:00:00Z The tests measuring amyloid actually measure the ratio of two different sizes of the amyloid peptide—similar to using the ratio of HDL to LDL blood cholesterol to evaluate lipids. Blood Tests for Alzheimer's: Two Experts on Why New Studies Are Encouraging 2019-08-13T04:00:00Z The tests measuring amyloid actually measure the ratio of two different sizes of the amyloid peptide — similar to using the ratio of HDL to LDL blood cholesterol to evaluate lipids. Two experts on why new Alzheimer's studies are encouraging 2019-08-10T04:00:00Z Later this month I’ll see what my HDL and LDL numbers look like. Perspective | Does a sugar detox work? I’m on it and have had some surprising results. 2019-08-02T04:00:00Z Research has shown that some people carry mutations that dramatically lower their natural levels of LDL, and in turn their risk of heart attack. One-off injection may drastically reduce heart attack risk 2019-05-10T04:00:00Z VLDL, or very low-density lipoproteins, is a precursor to LDL cholesterol, which is commonly seen as a major risk factor for cardiovascular disease. A new study links sugary drinks with disease. The reality is more complicated. 2019-05-01T04:00:00Z My LDL was 17 when last checked, and my total cholesterol was 82. Should you try to raise low cholesterol? 2019-04-17T04:00:00Z Researchers found that very low LDL, or “bad” cholesterol, and very low triglycerides are associated with an increased risk for hemorrhagic stroke, the type caused by a ruptured blood vessel in the brain. Very Low Cholesterol May Increase Stroke Risk 2019-04-10T04:00:00Z Most important to me is that for each 40-milligram drop in heart-damaging LDL on a statin, the risk of a major cardiovascular event drops by 25 percent each year. When the Benefits of Statins Outweigh the Risks 2019-03-18T04:00:00Z They raise blood levels of LDL, the “bad cholesterol,” and lower those of HDL, or “good cholesterol.” Trans Fat Bans May Be Good for the Heart 2019-02-28T05:00:00Z Dr. Jackson did not specify a target number for this year, and said he was focused on lowering the president’s LDL levels to under 120 mg/deciliter from 143 mg/deciliter. Trump Is in ‘Very Good Health’ Following His Annual Physical, His Doctor Says 2019-02-09T05:00:00Z A 1.0 mmol/L reduction in LDL cholesterol lowered the risk of major vascular events by about a fifth and a major coronary event by a quarter, when results from all age groups were combined. More over-75s 'should take statins' 2019-01-31T05:00:00Z Average LDL, or “bad” cholesterol, was 116, just above the 100 level considered healthy. Cholesterol May Be Higher After the Holidays 2019-01-02T05:00:00Z In addition to lowering blood levels of LDL, statins reduce inflammation, now recognized as an important risk factor for heart disease, and they stabilize the plaque that narrows coronary arteries. When the Benefits of Statins Outweigh the Risks 2019-03-18T04:00:00Z It is created from antibodies that dramatically lower levels of “bad” LDL cholesterol in the blood by blocking a certain protein. U.S. Supreme Court rejects Amgen over cholesterol medication patent... 2019-01-07T05:00:00Z Which raises the question, “What is a healthy level of both HDL and LDL cholesterol?” HDL Cholesterol: Too Much of a Good Thing? 2018-12-24T05:00:00Z Together, they discovered that patients with FH lack LDL receptors and exhibit increased LDL cholesterol production. The Widening Chasm between Research and Clinical Practice 2018-11-30T05:00:00Z But over three successive years in the first week of January, the average cholesterol was 240 and the average LDL was 143, both well into the unhealthy range. Cholesterol May Be Higher After the Holidays 2019-01-02T05:00:00Z It’s an oil with no trans fat - fats that drive up low-density lipoprotein, LDL, or “bad” cholesterol. Michigan soybean group pushes oil with no trans fats 2018-11-19T05:00:00Z The move away from LDL scores was loudly criticized by some clinicians when the 2013 recommendations were issued. New cholesterol management guidelines call for personalized risk assessments 2018-11-10T05:00:00Z However, the level of LDL cholesterol tells a different story. HDL Cholesterol: Too Much of a Good Thing? 2018-12-24T05:00:00Z After three months, Medicaid cut him off and asked Dr. Ferdinand to reapply for the drug and to document Mr. Scheidel’s LDL level to show the drug was working. These Cholesterol-Reducers May Save Lives. So Why Aren’t Heart Patients Getting Them? 2018-10-02T04:00:00Z Michels based her warning on the high proportion of saturated fat in coconut oil, which is known to raise levels of so-called LDL cholesterol, and so the risk of cardiovascular disease. Coconut oil is 'pure poison', says Harvard professor 2018-08-22T04:00:00Z They have borderline levels of LDL cholesterol, the dangerous kind. Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA 2018-08-13T04:00:00Z After doing this for about four months, continuing my exercise and strict diet, my total cholesterol dropped to 162, HDL 77, LDL 76, triglycerides 47. Lowering cholesterol with yeast rice, and a new use for gentian violet 2018-06-06T04:00:00Z By the way, my LDL were also within the normal range. Weighing the Pros and Cons of Statins 2018-04-16T04:00:00Z None found the benefits as promised, and one's LDL cholesterol and liver enzymes were threw the roof and another nearly died of pulmonary embolism. A Better Body in a Pill? Experts Urge Caution on SARMs 2018-04-12T04:00:00Z Participants lost an average of 10 pounds, lowered their LDL or “bad” cholesterol by 13 points, and improved blood- sugar control. Employers get serious about feeding workers more healthful food 2018-04-03T04:00:00Z Doctors who use only LDL to justify statins should be subject to malpractice actions. The Value and Limitations of a Cardiac Calcium Scan 2018-04-02T04:00:00Z You say your cholesterol numbers went up after taking fish oil supplements, but did you bother to test for LDL particle A & particle B? Is It Time to Give Up on Fish Oil? 2018-03-26T04:00:00Z Current thinking is more nuanced, considering the interplay of LDL and HDL levels. Statins help lower cholesterol, but are they the treatment for you? 2018-02-23T05:00:00Z In middle age, they had higher levels of triglycerides and LDL cholesterol. The Famine Ended 70 Years Ago, but Dutch Genes Still Bear Scars 2018-01-31T05:00:00Z Had Fluffy LDL checked NO signs of heart risk. Good Fats, Bad Fats 2018-01-29T05:00:00Z Trump’s LDL, the bad cholesterol, registered at 143, a number his doctor wants below 120. AP FACT CHECK: Trump disdained jobless rate, now loves it 2018-01-20T05:00:00Z “It’s reasonable to assume that untreated his LDL would be above the number we heard,” Chazal said. If Trump is as healthy as his doctor says, he’s beating long odds 2018-01-18T05:00:00Z She adds that clinical guidelines for the treatment of high cholesterol tend to focus on the bad cholesterol, in part because that’s what the drugs target: Statins lower LDL cholesterol. Statins help lower cholesterol, but are they the treatment for you? 2018-02-23T05:00:00Z Several said Mr. Trump’s goal should be to get his LDL below 100, or even under 70. Trump’s Physical Revealed Serious Heart Concerns, Outside Experts Say 2018-01-17T05:00:00Z Several said Trump’s goal should be to get his LDL below 100, or even under 70. Questions raised over Trump’s heart-attack risk after doctor’s report 2018-01-17T05:00:00Z More than a decade later, in 2001, doctors for President Bill Clinton, concerned about an increase in his weight and elevated LDL cholesterol levels, started the president on statin drugs to treat those symptoms. Trump Is in ‘Excellent Health,’ Doctor Says After Exam 2018-01-12T05:00:00Z They aggressively lower patients’ LDL cholesterol, optimize their blood pressure and blood sugar, and strongly encourage healthy diet and exercise habits. A Heart Risk Factor Even Doctors Know Little About 2018-01-09T05:00:00Z Good diet. exercise, sleep--no matter how "perfect", some people are born with high LDL. You’re Over 75, and You’re Healthy. Why Are You Taking a Statin? 2018-01-05T05:00:00Z LDL is known as "bad cholesterol" because high levels are linked with increased risk of heart disease. Is coconut oil a superfood? 2018-01-08T05:00:00Z “What was his LDL before he started taking it?” Questions raised over Trump’s heart-attack risk after doctor’s report 2018-01-17T05:00:00Z So by measuring LDL alone, doctors risk overlooking people who need treatment or, if they are already taking drugs to trim their cholesterol levels, a more intensive regimen. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z One is a contribution to an increase in HDL cholesterol, or “good cholesterol,” and a decrease in LDL oxidation, or “bad cholesterol.” Drinking red wine is good for you — or maybe not 2017-12-01T05:00:00Z LDL level is a "surrogate marker", and good science doesn't work that way. You’re Over 75, and You’re Healthy. Why Are You Taking a Statin? 2018-01-05T05:00:00Z Not only was there no rise in LDL levels, which was what we were expecting, but there was a particularly large rise in HDL, the "good" cholesterol, up by 15% Is coconut oil a superfood? 2018-01-08T05:00:00Z The cardiologists said the president’s weight and diet were a serious problem that probably contributed to his high LDL level and increased his risk for heart problems. Questions raised over Trump’s heart-attack risk after doctor’s report 2018-01-17T05:00:00Z LDL cholesterol is deeply entrenched in medical routines, and "it's not going to change any time soon," Rader says. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z Why just monitor LDL when you can check for the that which LDL is supposed to be linked to? Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z But I agree with you about LDL being a surrogate marker; to me, the important points are the drug effect on overall mortality AND quality of life. You’re Over 75, and You’re Healthy. Why Are You Taking a Statin? 2018-01-05T05:00:00Z Interesting..Living with Diabetes 2 and elevated LDL -- famillial disease and a tendency to like sweets and overeat .. Amish Mutation Protects Against Diabetes and May Extend Life 2017-11-15T05:00:00Z Reporting a lower cholesterol, lower LDL, lower BP one at a time made no difference. Under New Guidelines, Millions More Americans Will Need to Lower Blood Pressure 2017-11-13T05:00:00Z Although these people showed further decreases in LDL cholesterol, their apoB levels—and their cardiovascular risk—didn't decline by as much. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z These people are considered high risk because we know high LDL cholesterol is a strong risk factor for atherosclerotic cardiovascular disease. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z My HDL/LDL ratio used to be OK, and now it is not so good, after switching my diet to a lot of fat... Can Ketones Rev Up Our Workouts? 2017-11-08T05:00:00Z Is my blood level of that nasty LDL cholesterol in check—say, below 100 mg/dL? Strict Targets for Cholesterol, Blood Pressure, and More Don't Always Make Sense 2017-11-20T05:00:00Z Almonds are high in monounsaturated fats, which may explain why they’ve been shown to lower “bad” LDL cholesterol while maintaining — or even improving — “good” HDL cholesterol. You should be eating more nuts 2017-11-13T05:00:00Z Total cholesterol level was the first widely used indicator of this risk, but after researchers discovered that one form of cholesterol, HDL, may be protective, LDL cholesterol became the benchmark. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z The decision is really if your want to have healthy musulature or lower HDL/LDL numbers on your chart. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z Those who took olive oil saw their heart rate variability decline when inhaling the pollution; levels of unhealthy LDL cholesterol and triglycerides also went up — two risk factors for heart disease. Opinion | Does Eating Right Protect You From Air Pollution? 2017-10-19T04:00:00Z An LDL level above 190 mg/dL should be treated, no matter what. Strict Targets for Cholesterol, Blood Pressure, and More Don't Always Make Sense 2017-11-20T05:00:00Z “When we looked, there was one variant that was more certain, for LDL cholesterol, and the gene the Vindija individual carried is protective,” Prüfer says. New Clues to How Neanderthal Genes Affect Your Health 2017-10-05T04:00:00Z Now, some physicians favor non-HDL cholesterol, which encompasses multiple cholesterol types, including LDL and VLDL. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z Neither LDL nor total cholesterol are very meaningful as risk factors. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z Stephen O’Rahilly, director of the Metabolic Research Laboratories at Cambridge University, said high-fat diets drive up LDL or “bad” cholesterol in humans, and so raise the risk of heart disease. Could a drug that mimics a zero-carb diet help us live longer, healthier lives? 2017-09-05T04:00:00Z Research had shown that high levels of LDL cholesterol in blood were linked with an increased risk of heart disease and stroke, and we knew eggs were packed with cholesterol. Nutrition science isn’t broken, it’s just wicked hard 2017-07-21T04:00:00Z Take Inclisiran, a drug that recently completed Phase 2 trials in which it showed remarkable reductions in LDL cholesterol levels. High Drug Prices Are Bad. Cutting Them Could Be Worse. 2017-06-30T04:00:00Z At the same time, some people taking drugs for what seem to be dangerously high LDL cholesterol levels may not need treatment, Sniderman says. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z My LDL went way down and my HDL went way up. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z But lowering LDL cholesterol is only one factor in the complexity of factors that influence arterial health. Dr. Andrew Weil Says We’re Taking Too Many Medicines 2017-06-22T04:00:00Z We all need it, but too much "bad" LDL cholesterol increases the risk of cardiovascular diseases. Cholesterol-lowering jab to help prevent heart disease - BBC News 2017-06-19T04:00:00Z To prevent heart disease, we’ve been told to keep LDL levels down and HDL levels up — with 45 milligrams per deciliter usually offered as a good target for the latter. Does ‘good’ cholesterol still matter? 2017-05-26T04:00:00Z "The data support that it's the LDL particles themselves that are the bad actors," rather than the cholesterol they contain, Rader says. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z A lifelong exposure to very high LDL cholesterol, caused by this genetic disorder that affects 1 in 250 people, can dramatically increase your risk for an early heart attack. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z And so were her levels of LDL, which raises the risk of heart disease, and HDL, which is linked to a lower risk. Rare Gene Mutations Inspire New Heart Drugs 2017-05-24T04:00:00Z Michael Joyner, a medical doctor and integrative physiology researcher at the Mayo Clinic in Rochester, Minnesota, also notes that over 70% of the participants are currently taking prescribed medication for high LDL cholesterol and hypertension. This $25,000 physical has found some ‘serious’ health problems. Others say it has serious problems 2017-05-12T04:00:00Z Their aim is primarily to reduce LDL cholesterol, not provide blanket assurance of "perfect cholesterol readings." Heart Attack Survivors Often Fail to Take Statins 2017-04-24T04:00:00Z Still, even apoB advocates admit that LDL cholesterol's track record is pretty good. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z FH is passed down in families, so if you have early heart disease in your family and very high LDL cholesterol from a young age, please get evaluated and get your kids cholesterol checked too. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z Sometimes a low dose of thyroxine can modify HDL/LDL ratios & metabolic rates. Could Be the Thyroid; Could Be Ennui. Either Way, the Drug Isn’t Helping. 2017-04-21T04:00:00Z These include reduced insulin sensitivity, higher blood-sugar levels and increases in LDL cholesterol and triglycerides. Coated aspirin may be riskier for digestive tract 2017-04-09T04:00:00Z In addition to tracking body mass index, physical activity, and demographic and behavioral characteristics, they assessed four risk factors for cardiovascular disease: LDL cholesterol, triglycerides, blood pressure and glucose tolerance. Healthy Weight? You May Still Be at Risk for Heart Disease 2017-04-06T04:00:00Z "The argument is that LDL cholesterol is good enough," he says. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z My LDL was very high and my HDL was very low. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z This medication reduced LDL levels to an almost unfathomable 30 mg/dl from about 90 mg/dl on average, which is typically considered low. An End to Heart Disease? Not Quite 2017-03-20T04:00:00Z And the FDA approved evolocumab, made by Amgen in Thousand Oaks, California, only for certain patients, such as those with a hereditary condition that causes extremely high levels of LDL. Genome-based cholesterol drug boosts heart health 2017-03-16T04:00:00Z The data reinforce the growing body of evidence showing that as clinicians push LDL cholesterol levels ever lower, their patients fare better. Powerful heart drug sharply cuts risks for cardiac patients on statins 2017-03-17T04:00:00Z Those taking the new drug reached an average LDL of 30. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z I was taking a very high dose of Statins, which did lower my LDL as long as I kept taking the drugs, but these drugs didn't raise my HDL. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z It may seem obvious that lowering LDL cholesterol would inevitably reduce the risk of heart disease. An End to Heart Disease? Not Quite 2017-03-20T04:00:00Z Red yeast rice supplements are touted as a way to reduce “bad” LDL cholesterol. Some good reasons to be cautious about using dietary supplements 2017-02-10T05:00:00Z Currently, an LDL cholesterol below 100 is considered optimal for people at risk of heart disease, according to the Mayo clinic. Powerful heart drug sharply cuts risks for cardiac patients on statins 2017-03-17T04:00:00Z A quarter of participants got to an LDL of 19 or lower. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z I also then switched to a plant based diet and this seemed to help lower my LDL even further without lowering the HDL. Am I at High Risk for a Heart Attack? 2017-11-24T05:00:00Z The benefit is likely to be greatest among those with the most risk, including people with very high LDL levels despite treatment. An End to Heart Disease? Not Quite 2017-03-20T04:00:00Z Research suggests that green tea helps to reduce total cholesterol, and that both green and black teas help reduce “bad” LDL cholesterol and lower blood pressure. Is a cup of tea good for you? 2017-01-18T05:00:00Z "It takes time for LDL lowering to translate into healthier arteries," he said. Powerful heart drug sharply cuts risks for cardiac patients on statins 2017-03-17T04:00:00Z The lower the LDL, the lower the risk, with no leveling off of the linear relationship. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z It said Praluent, a drug intended to lower "bad" LDL cholesterol by blocking a protein known as PCSK9, infringed its patents related to the protein. U.S. Judge Blocks Sanofi and Regeneron From Selling Cholesterol Drug 2017-01-05T05:00:00Z In 2015, the Food and Drug Administration approved a new class of drugs for the reduction of LDL cholesterol, the type associated with heart disease and stroke. An End to Heart Disease? Not Quite 2017-03-20T04:00:00Z He also began taking a statin to lower his elevated LDL cholesterol level. He was set for surgery — until another doctor said the diagnosis was all wrong 2016-12-09T05:00:00Z He said the main criteria for him would be an analysis of the patient's baseline risk and those most likely to see the largest reduction in LDL cholesterol. Powerful heart drug sharply cuts risks for cardiac patients on statins 2017-03-17T04:00:00Z The new drug, Amgen’s Repatha, is given as a shot once or twice a month and is part of a novel class of medicines that drop LDL to unprecedented levels. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z He takes the maximum doses of a statin and two other less effective cholesterol-lowering drugs, but even so, he and Dr. Baum say, his LDL level bounces around in the 200’s, sometimes reaching 300. Study Shows Promise for Expensive Cholesterol Drugs, but They Are Still Hard to Obtain 2016-11-15T05:00:00Z Would more lives be saved, and more heart attacks averted, if LDL targets were set lower? Drug Combo May Dissolve Heart Attack-Causing Plaque 2016-11-15T05:00:00Z The sweet fructose component, whether “natural” in your orange juice or as “added sugar,” is a major cause of coronary artery disease via production of small, dense LDL particles. Putting Sugary Soda Out of Reach 2016-11-03T04:00:00Z European Society of Cardiology focuses more on managing LDL. New statin guidelines: Everyone 40 and older should be considered for the drug therapy 2016-11-13T05:00:00Z Statins such as Lipitor and Crestor are cheap and lower LDL, or bad cholesterol, but some people can’t tolerate or get enough help from them. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z In the new study, patients taking a statin had LDL levels averaging 93, which is considered excellent. Study Shows Promise for Expensive Cholesterol Drugs, but They Are Still Hard to Obtain 2016-11-15T05:00:00Z Do the drugs, which both work on cholesterol receptors in the liver but in slightly different ways, combine forces to lower LDL even further than either alone? Drug Combo May Dissolve Heart Attack-Causing Plaque 2016-11-15T05:00:00Z But the different trials showed that each unit of LDL cholesterol removed from the bloodstream protects heart health, regardless of how doctors are able to drive those cholesterol levels down. Are There Alternatives to Statins? 2016-09-27T04:00:00Z “If you look at older versions of the guidelines, there was a focus on getting LDL cholesterol down through a series of different options,” says Sabatine. Statins Aren't the Only Way to Lower Cholesterol 2016-09-27T04:00:00Z The new drug, Amgen’s Repatha, is given as a shot once or twice a month and is part of a novel class of medicines that drop LDL to unprecedented levels. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z And the lower the LDL level for the evolocumab patients went, the more likely it was that plaques would shrink. Study Shows Promise for Expensive Cholesterol Drugs, but They Are Still Hard to Obtain 2016-11-15T05:00:00Z Among nearly 1,000 people with heart disease in six countries, they found that the combined effect of the PCSK9 inhibitor evolocumab and a statin lowered LDL dramatically — more than either drug alone. Drug Combo May Dissolve Heart Attack-Causing Plaque 2016-11-15T05:00:00Z "There is a linear relationship between what your LDL cholesterol level is and what your risk is of cardiovascular events," Sabatine said. Are There Alternatives to Statins? 2016-09-27T04:00:00Z “In our country the average LDL is 120 to 130 mg/dL, but that doesn’t mean it’s normal,” he says. Statins Aren't the Only Way to Lower Cholesterol 2016-09-27T04:00:00Z “There was a lot of hubris about how pushing LDL down to 30 would eliminate heart disease,” he said. Cholesterol-slashing drug lowers heart-attack risk, study finds 2017-03-17T04:00:00Z At the lowest LDL levels — around 24 — 81 percent of patients’ plaques shrank. Study Shows Promise for Expensive Cholesterol Drugs, but They Are Still Hard to Obtain 2016-11-15T05:00:00Z They also prevent stroke and heart attack-triggering plaque from building up within the arteries, while also showing significant ability to lower "bad" LDL cholesterol levels. The Ultimate Grocery Shopping List to Replace Your Medicine Cabinet 2016-09-26T04:00:00Z She said the evidence review "supports that there are several options to lower LDL cholesterol and they all lower risk for cardiovascular disease." Are There Alternatives to Statins? 2016-09-27T04:00:00Z But the levels were in the normal range in the recent tests: cholesterol, 169; HDL cholesterol, 63; LDL cholesterol, 94; triglycerides, 61. A Doctor’s Assessment of Whether Donald Trump’s Health Is ‘Excellent’ 2016-09-18T04:00:00Z And he said he was wrong to encourage people to consume saturated fat because it increases LDL cholesterol, which correlates with heart disease. An Unconventional Cardiologist Promotes a High-Fat Diet 2016-08-23T04:00:00Z Pence’s total cholesterol level is 216, with triglycerides at 57, HDL at 55 and LDL at 150. Pence releases letter from doctor indicating good health 2016-09-17T04:00:00Z His total cholesterol was 169; his LDL or "bad" cholesterol was 94, and his HDL or "good" cholesterol was 63. New note from doctor says Trump's health is excellent 2016-09-15T04:00:00Z Trumps LDL cholesterol is considered in the optimal range, at 94 mg/dL. What Trump's Health Stats Mean 2016-09-15T04:00:00Z The note put his cholesterol level in normal range, with HDL cholesterol at 63, LDL at 94 and triglycerides at 61. New Doctor’s Note Describes Donald Trump’s Health as ‘Excellent’ 2016-09-15T04:00:00Z “Decades of studies are consistent in showing that LDL is pivotal and that by reducing LDL you reduce cardiovascular events,” Dr. Poulter said. An Unconventional Cardiologist Promotes a High-Fat Diet 2016-08-23T04:00:00Z But you shouldn’t need to test more frequently than every six months, and if you do test at home, look for a test that breaks down cholesterol into LDL, HDL and triglycerides. Sit up straight to test blood pressure. Don’t exercise hard before cholesterol check. 2016-09-09T04:00:00Z Her total cholesterol was 195; her LDL or "bad" cholesterol was 118, and her HDL or "good" cholesterol was 64 - all within healthy levels and not signaling the need for any medications. Doctors: Pneumonia is serious but Clinton should bounce back 2016-09-11T04:00:00Z Her total cholesterol was 195; her LDL or “bad” cholesterol was 118, and her HDL or “good” cholesterol was 64 – all within healthy levels and not signaling the need for any medications. Doctors: Pneumonia is serious but Clinton should bounce back 2016-09-11T04:00:00Z However, HDL and LDL cholesterol levels are important, he says, especially HDL – the good cholesterol. 10 Commandments to Reduce Your Risk of Stroke 2016-08-10T04:00:00Z On average, the buckwheat diet resulted in decreases in total cholesterol, low-density lipoprotein or LDL, and triglycerides. The Harder You Bite, the Longer You Live? 2016-08-08T04:00:00Z The researchers noted small dense LDL, a type of cholesterol tied to heart disease, also disappeared. Cutting Down on Sweets Can Help Kids' Hearts 2016-07-19T04:00:00Z People with the most variation in their LDL levels over the study’s 2.5-year follow up showed the lowest scores on the cognitive tests. Here's What Cholesterol Can Do To the Brain 2016-07-18T04:00:00Z However, driving LDL levels down into the 70 mg/dL range did not translate into any further drop in risk, the study found. Just a Little of Statins' Effect Enough to Help Heart: Study 2016-06-20T04:00:00Z Savvy Goldman types have long favoured the nifty acronym LDL – let’s discuss live – as a way of avoiding writing the wrong things down. Goldman Sachs’ email censorship sends the wrong message | Stefan Stern 2016-06-20T04:00:00Z This sequence of events may even overshadow the effects of LDL cholesterol, the so-called bad kind. Is Sugar Really Bad for You? It Depends 2016-06-08T04:00:00Z At my recent checkup, all my blood tests were within normal range, including triglycerides, HDL, LDL, total cholesterol and glucose. A healthy senior questions the need for statin 2016-05-22T04:00:00Z Now, in a study published in the journal Circulation, researchers find that changes in levels of LDL cholesterol may be especially harmful to cognitive functions. Here's What Cholesterol Can Do To the Brain 2016-07-18T04:00:00Z The researchers determined that the risk for such events was significantly lower among patients with moderate LDL levels, compared to patients with high LDL levels. Just a Little of Statins' Effect Enough to Help Heart: Study 2016-06-20T04:00:00Z Both drugs were introduced last year to reduce levels of LDL cholesterol, or “bad” cholesterol, beyond what can be achieved by an older class of drugs known as statins. Health Insurers Push to Tie Drug Prices to Outcomes 2016-05-11T04:00:00Z “What many people don’t realize is that it’s triglycerides and HDL that are more predictive of cardiovascular disease than LDL cholesterol,” Dr. Malhotra said. Is Sugar Really Bad for You? It Depends 2016-06-08T04:00:00Z There was no measurement of LDL and HDL cholesterol or triglycerides. A Study on Fats That Doesn’t Fit the Story Line 2016-04-15T04:00:00Z The scientists, led by Dr. Roelof Smit at Leiden University Medical Center in the Netherlands, studied 535 elderly people enrolled in a study involving a statin, a medication that lowers LDL cholesterol. Here's What Cholesterol Can Do To the Brain 2016-07-18T04:00:00Z Part of the problem was that high-level Goldman executives had been savvier in how they communicated: when topics broached sensitive territory in e-mails, they would often write “LDL”—let’s discuss live. Why the S.E.C. Didn’t Hit Goldman Sachs Harder 2016-04-21T04:00:00Z “These new therapies offer additional LDL cholesterol lowering and outcomes studies are still pending,” said the firm. Breakthrough cholesterol drugs fizzle amid price pushback 2016-04-20T04:00:00Z “I’m not saying LDL isn’t important. But if there is a hierarchy, triglycerides and HDL are more important than LDL.” Is Sugar Really Bad for You? It Depends 2016-06-08T04:00:00Z LDL cholesterol is quickly followed by white blood cells and thus begins the process of plaque formation, consisting mainly of cholesterol, fatty substances and waste products of cells. Inflammation and Heart Disease: What Is C-Reactive Protein? Who Might Benefit from Testing? 2016-04-06T04:00:00Z In another study released Sunday morning, researchers showed that a drug that raises HDL cholesterol, the so-called good cholesterol, and lowers LDL cholesterol does not help high-risk heart patients. Statin intolerance is real, researchers find. Another (more costly) drug may get around the problem. 2016-04-03T04:00:00Z “It’s the most mind-boggling question. How can a drug that lowers something that is associated with benefit not show any benefit?” he said, referring to the 37 percent drop in LDL levels with the drug. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z Caught in the middle of the coverage fight are patients who say they desperately need more options to control bad cholesterol, or LDL. Breakthrough cholesterol drugs fizzle amid price pushback 2016-04-20T04:00:00Z These foods also appear to help lower blood levels of "bad" LDL cholesterol, he added. Beans, Chickpeas May Help With Weight Loss: Study 2016-03-30T04:00:00Z The study showed a greater reduction in both LDL cholesterol and hsCRP with the combination of drugs. Inflammation and Heart Disease: What Is C-Reactive Protein? Who Might Benefit from Testing? 2016-04-06T04:00:00Z The Food and Drug Administration approved PCSK9 inhibitors last year, but only for small groups of people, including those with an inherited disease that dramatically elevates their LDL cholesterol levels. Statin intolerance is real, researchers find. Another (more costly) drug may get around the problem. 2016-04-03T04:00:00Z It seemed logical that evacetrapib, by ridding the body of cholesterol in HDL and lowering the amount of LDL proteins, would work to protect against heart disease. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z For instance, for LDL cholesterol, both Theranos and LabCorp reported results out of the normal range for many of the same people, while Quest reported normal levels for them. Study of Theranos Medical Tests Finds Irregular Results 2016-03-28T04:00:00Z Compared to the muffin eaters, the almond eaters reduced their LDL cholesterol, belly fat and waist circumference, suggesting that almonds trump high-carb snacks in preventing heart disease and diabetes. 10 Foods Every Plant-Based Diet Needs 2016-03-24T04:00:00Z LDL cholesterol is believed to collect in the walls of blood vessels, ultimately blocking the flow of blood and leading to heart attacks and strokes. 'Good' cholesterol mutation linked to heart disease 2016-03-09T05:00:00Z The monthly injections of the PCSK9 inhibitor proved far more effective after 24 weeks, cutting patients' LDL cholesterol by an average of 52.8 percent, compared to 16.7 percent for the other drug. Statin intolerance is real, researchers find. Another (more costly) drug may get around the problem. 2016-04-03T04:00:00Z It is a drug that reduces levels of LDL cholesterol, the dangerous kind, as much as statins do. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z The president's LDL, or "bad," cholesterol is at 125. The president's doctor says he remains in excellent overall health and has even improved from his last physical 2016-03-08T05:00:00Z One recent study found that feeding rabbits spirulina reduced their HDL levels while increasing LDL, or low-density lipoprotein – the "good" cholesterol. 5 Reasons to Add Spirulina to Your Diet 2016-03-08T05:00:00Z A large body of genetic and molecular studies, and the rampant success of some drugs that lower LDL cholesterol, back up this idea. 'Good' cholesterol mutation linked to heart disease 2016-03-09T05:00:00Z Yet there are still recommendations to limit saturated fat because it raises total cholesterol and LDL cholesterol. Making a Case for Eating Fat 1464-03-31T05:00:00Z Participants taking the drug saw their LDL levels fall to an average of 55 milligrams per deciliter from 84. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z A brochure for the Four Sigmatic elixir echoes the general wellbeing and heart health claims, saying “reishi reduces the possibility of heart disease” by lowering the LDL cholesterol levels and blood pressure. Mushroom Hot Cocoa Is Now a Thing 2016-03-02T05:00:00Z Whole grains also help lower “bad” LDL cholesterol and blood pressure and promote stable blood-sugar levels to keep Type 2 diabetes at bay. Eat and Drink Your Way to a Healthier Heart 2016-02-17T05:00:00Z Later research put the LDL drop at closer to 3 percent, so the FDA is reconsidering the label claim. Should you eat more soy? 2016-02-12T05:00:00Z Statins interfere with the production of cholesterol by the liver, and thus help lower "bad" LDL cholesterol and raise "good" HDL cholesterol levels in the bloodstream, according to the U.S. U.S. Task Force Backs Statins for Those 40 to 75 at Heightened Heart Risk 2015-12-21T05:00:00Z The other raised HDL levels but did not lower LDL levels at all. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z But the effect of LDL may depend on its type. Just in Time for the Holidays: Fat, Sugar and Grandma’s Cooking 2015-12-15T05:00:00Z Why it’s good for you: Endive is high in inulin and fiber, which can lower LDL cholesterol levels to benefit the heart. The 50 (New) Healthiest Foods of All Time—With Recipes 2015-11-23T05:00:00Z For those patients, the drugs may be crucial for lowering LDL. Need help paying for Amgen's Repatha? Get ready to give up your privacy 2015-11-13T05:00:00Z The scientists had been investigating a liver protein, dubbed PCSK9, that's responsible for circulating harmful LDL cholesterol in the human body. And the Oscar of Science Goes To … 2015-11-08T05:00:00Z “It may be that the LDL level is less important than how it gets changed,” said Dr. Paul Thompson, a cardiologist at Hartford Hospital. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z For instance, small, dense LDL seems to increase the clogging of our arteries. Just in Time for the Holidays: Fat, Sugar and Grandma’s Cooking 2015-12-15T05:00:00Z Only patients in the shared physician-patient incentives group achieved reductions in LDL cholesterol levels that were statistically different from those in the control group, the researchers found. 'Cash for Lower Cholesterol' Program Works With Doc-Patient Teams 2015-11-08T05:00:00Z These include patients with the inherited condition familial hypercholesterolemia, which causes abnormally high levels of LDL, or atherosclerotic heart conditions. Need help paying for Amgen's Repatha? Get ready to give up your privacy 2015-11-13T05:00:00Z In July, the Food and Drug Administration approved the first of two new PCSK9 inhibitors that lower the bad type of cholesterol, LDL. I Am Paying for Your Expensive Medicine 2015-11-07T05:00:00Z Cardiologists still have high hopes for a new class of cholesterol drugs, known as PCSK-9 inhibitors, that cause LDL to plummet to levels never seen in drug treatments. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z Well, saturated fats may lower small, dense LDL, while raising large, buoyant LDL. Just in Time for the Holidays: Fat, Sugar and Grandma’s Cooking 2015-12-15T05:00:00Z Research also shows that lentils help reduce total and LDL cholesterol, the risk of heart attack and chronic inflammation. 7 Pantry Essentials Dietitians Always Have On Hand 2015-11-05T05:00:00Z Their triglyceride and LDL levels also declined and, most importantly, they showed less fat in their liver. Sugar Is Toxic, Says New Study 2015-10-27T04:00:00Z On average, the subjects’ LDL cholesterol, the kind implicated in heart disease, fell by 10 points. Cutting Sugar Improves Children's Health in Just 10 Days 2015-10-27T04:00:00Z These drugs are being tested in large clinical trials to see if their effects on LDL levels translate into reduced incidences of heart attacks, strokes and death. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z Two drugs, known as PCSK9 inhibitors, were approved this year, promising to reduce the level of “bad” LDL cholesterol far more than cheaper drugs called statins. Medicare spending for hepatitis C cures surges 2015-10-16T04:00:00Z His LDL was 64 mg/dl, HDL 89 mg/dl and triglycerides 33 mg/dl. Letter From Physician Attests to Jeb Bush’s Health 2015-10-15T04:00:00Z Less PCSK9 means more receptors and hence, the theory goes, lower LDL levels. The slopes of enlightenment 2015-10-15T04:00:00Z The results show that improvements in biomarkers like LDL and HDL do not always translate into a clinical benefit. Eli Lilly Abandons Heart Disease Drug in Final Stage of Trials 2015-10-12T04:00:00Z Statins, in contrast, pull cholesterol from the other major cholesterol-carrying protein, LDL, into the liver, after which it can be discarded. Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health 2016-04-03T04:00:00Z Both drugs were recently approved by the Food and Drug Administration and represent the first significant breakthrough in the treatment of high LDL, the "bad" cholesterol, in more than 20 years. Prescription firm agrees to cover pricey new cholesterol drugs -- for some 2015-10-06T04:00:00Z Her mother died of a heart attack and Mrs. Barnett knew her level of LDL cholesterol, the bad kind, was very high at 190. Heart Scan Can Fine-Tune Risk Estimate for Patients Considering Statins 2015-10-05T04:00:00Z Patients who received automated text messages throughout their week saw improvements in their "bad" LDL cholesterol levels, blood pressure and weight, the study found. Could a Texting App Help Your Heart? 2015-09-22T04:00:00Z The injected drugs improve the liver's ability to reduce LDL, the "bad cholesterol" tied to increased risk for heart attacks and strokes, by 50% or more. New prescription drugs can help patients, but their high prices elicit ire 2015-09-20T04:00:00Z Dr. Gattuso also broke from the current orthodoxy in his distaste for statins, medicines that reduce harmful LDL cholesterol in the blood. ‘Be Well Weekend’ at Omni Bedford Springs Resort teaches health, diet secrets 2015-09-13T04:00:00Z In clinical trials they lowered the level of LDL cholesterol, the so-called bad kind, by 40 percent or more, even when patients were already taken statins. New Cholesterol Drugs Are Vastly Overpriced, Analysis Says 2015-09-08T04:00:00Z She tried lowering her LDL level by becoming a vegetarian, but it did not budge. Heart Scan Can Fine-Tune Risk Estimate for Patients Considering Statins 2015-10-05T04:00:00Z About one in four American adults takes statins, pills that block an enzyme needed to make LDL. New Alternatives to Statins Add to a Quandary on Cholesterol 2015-08-29T04:00:00Z The companies are conducting cardiovascular outcomes trials to determine whether their ability to dramatically lower bad LDL cholesterol will lead to fewer heart attacks, strokes and deaths. FDA Approves New Cholesterol-Lowering Drug 2015-08-28T04:00:00Z Low-density lipoprotein, commonly known as LDL, builds up in the blood from natural and food sources, and is a leading cause of heart disease. FDA Approves Repatha for High Cholesterol 2015-08-28T04:00:00Z Food and Drug Administration on Thursday approved a second drug that's part of a potent new class of medications that sharply cut levels of "bad" LDL cholesterol. FDA Approves Second Drug in New Class of Cholesterol-Lowering Medications 2015-08-27T04:00:00Z Developed by Amgen’s scientists, Repatha is the second in a new class of drugs that lower cholesterol by blocking a protein called PCSK9 that interferes with the body’s ability to remove LDL. FDA approves Amgen cholesterol-lowering drug Repatha for some patients 2015-08-27T04:00:00Z The new drugs are approved for use by people with heart disease who cannot control their LDL, the dangerous cholesterol, by other means. New Alternatives to Statins Add to a Quandary on Cholesterol 2015-08-29T04:00:00Z Many cardiologists, though, are persuaded by a large body of evidence supporting the idea that the lower the LDL, the lower the risk. F.D.A. Approves Another in a New Class of Cholesterol Drugs 2015-08-27T04:00:00Z In a clinical study, participants taking Repatha saw an average drop in LDL cholesterol of about 60 percent, compared with those who took a placebo, the FDA said. FDA Approves Repatha for High Cholesterol 2015-08-28T04:00:00Z For others, statins just don't do the job -- including people with familial hypercholesterolemia, an inherited condition that causes very high LDL levels and heart attacks at an early age. FDA Approves Second Drug in New Class of Cholesterol-Lowering Medications 2015-08-27T04:00:00Z FDA officials said they approved Repatha for certain patients who are unable to control their LDL cholesterol with current treatment options. FDA approves Amgen cholesterol-lowering drug Repatha for some patients 2015-08-27T04:00:00Z Advertisement The medicines can slash LDL to levels almost never before seen in adults. New Alternatives to Statins Add to a Quandary on Cholesterol 2015-08-29T04:00:00Z But company scientists realized it would not be enough to show that the drugs slash LDL levels. F.D.A. Approves Another in a New Class of Cholesterol Drugs 2015-08-27T04:00:00Z This type of fat poses significant heart-health risks: For every 1 percent increase in energy from saturated fat intake, LDL cholesterol concentration, the undesirable type of cholesterol, increases by about 2 percentage points. 5 Dietary Guidelines for a Healthy Heart 2015-08-11T04:00:00Z The new guidelines dropped an emphasis on specific targets for LDL levels. UPDATE 2-Pharmacy benefit manager CVS urges rewrite for U.S. heart guidelines 2015-08-10T04:00:00Z LDL is a significant risk factor for heart attack and stroke. FDA approves Amgen cholesterol-lowering drug Repatha for some patients 2015-08-27T04:00:00Z However, high LDL cholesterol, while harmful over many years, is symptomless and the FDA was concerned that patients would either misdiagnosis themselves or not be motivated to get their blood tested in the first place. Pfizer Pulls The Plug On OTC Lipitor And It's The Patients' Fault 2015-07-29T04:00:00Z “I believe lower is better and do not believe that a very low LDL is harmful,” said Dr. Daniel Rader, a cardiologist at the University of Pennsylvania. F.D.A. Approves Another in a New Class of Cholesterol Drugs 2015-08-27T04:00:00Z It often leaves him exhausted, but it drives his LDL level down to about 120, at least temporarily. Praluent Looks Cheap to Those With Extreme Cholesterol 2015-07-27T04:00:00Z Instead, they suggest that an individual patient's risk of developing heart disease rather than an LDL number should be used to determine the need for more intensive treatment. UPDATE 2-Pharmacy benefit manager CVS urges rewrite for U.S. heart guidelines 2015-08-10T04:00:00Z They work by blocking PCSK9, a protein that degrades the receptors on liver cells that grab LDL from the blood to clear it from the body. Patients Seeking Alternatives to Statins May Undergo Rigorous Vetting 2015-07-27T04:00:00Z The drug is an antibody that inhibits the PCSK9 protein, which allows more liver receptors to remove LDL from the blood, lowering "bad" cholesterol. Praluent Approved to Treat High Cholesterol 2015-07-27T04:00:00Z In 1998, prominent cardiologists argued in the journal Circulation that an LDL level of 125 mg/dL was optimal for people at high risk. F.D.A. Approves Another in a New Class of Cholesterol Drugs 2015-08-27T04:00:00Z "The clinical studies we've done to date really have shown exactly what we've hoped for, which is a truly unprecedented ability to lower LDL cholesterol," he said. FDA approves breakthrough cholesterol drug, but only for certain high-risk patients 2015-07-24T04:00:00Z One recent review of 24 clinical trials -- published in the Annals of Internal Medicine -- found that PCSK9 inhibitors lowered people's LDL cholesterol by about 47 percent, on average. FDA OKs First of New Class of Cholesterol Drugs 2015-07-24T04:00:00Z When untreated, her LDL is around 400; experts, before recently abandoning specific cholesterol targets, considered optimal levels as below 100. Patients Seeking Alternatives to Statins May Undergo Rigorous Vetting 2015-07-27T04:00:00Z Participants given Praluent saw a reduction in LDL cholesterol ranging from 36 percent to 59 percent, the FDA said. Praluent Approved to Treat High Cholesterol 2015-07-27T04:00:00Z Today, doctors often tell people at high risk for heart attacks to aim for LDL levels of 70 mg/dL. F.D.A. Approves Another in a New Class of Cholesterol Drugs 2015-08-27T04:00:00Z "The ability to lower LDL for these high-risk patients is incredibly important." FDA approves breakthrough cholesterol drug, but only for certain high-risk patients 2015-07-24T04:00:00Z For others, statins just don't do the job -- including people with inherited conditions like HeFH, which causes very high LDL levels and heart attacks at an early age. FDA OKs First of New Class of Cholesterol Drugs 2015-07-24T04:00:00Z Sure enough, they found 33 people whose LDL levels were about 40% lower than average and who shared mutations that effectively silenced PCSK9. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z But when she began taking one of the new drugs in a study her LDL levels dropped below 50. U.S. Approves Drug That Can Sharply Lower Cholesterol Levels 2015-07-24T04:00:00Z The new medications are known as PCSK9 inhibitors because they block a substance that hinders the liver’s ability to remove bad, or LDL, cholesterol from the blood. New cholesterol-lowering medications likely to trigger fight over prices 2015-07-21T04:00:00Z Both drugs lower low-density lipoprotein, or LDL, cholesterol more powerfully and in a different ways than currently available drugs. Europe approves Amgen's first-in-class cholesterol drug 2015-07-21T04:00:00Z LDL is often called "bad cholesterol" because high levels are associated with an increased risk of heart disease. Can you lower your cholesterol just by changing your diet? - BBC News 2015-07-20T04:00:00Z These PCSK9 mutations associated with the lowest LDL appeared predominantly in African-American participants. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z About nine months ago, even though she was taking a statin and other drugs, her LDL level was about 167, much higher than the 70 or 100 that would be recommended for her. U.S. Approves Drug That Can Sharply Lower Cholesterol Levels 2015-07-24T04:00:00Z Advocates say the new drugs fill a need for some of the estimated 73 million Americans who suffer from high LDL cholesterol. New cholesterol-lowering medications likely to trigger fight over prices 2015-07-21T04:00:00Z The new guidelines focus more specifically on the use of statins -- drugs such as Crestor, Lipitor and Zocor -- to prevent heart disease by lowering "bad" LDL cholesterol. Wider Use of Statin Drugs Could Save Thousands More Lives: Report 2015-07-14T04:00:00Z Cholesterol and LDL particles are used as a building block for making steroid hormones, too, such as testosterone, progesterone and estrogens. Good Fat, Bad Fat: Which is Which 2015-06-30T04:00:00Z Essentially, their LDL amounts were about the same as those who relied on statins to drop their cholesterol. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z However, it failed to reduce the number of heart attacks and strokes in people with good control of their LDL levels. ‘Good’ Cholesterol: What’s in a Number? 2015-06-29T04:00:00Z In a statement, Amgen noted that despite the huge annual spending on cardiovascular disease in the United States, many patients can’t keep their LDL levels in check. New cholesterol-lowering medications likely to trigger fight over prices 2015-07-21T04:00:00Z Saturated fat increases levels of LDL cholesterol, which are associated with higher rates of heart disease—but saturated fat also seems to raise HDL cholesterol, which might help ease those effects. Should I Eat Butter? 2015-06-18T04:00:00Z "I think the first patients to receive this drug will be those with familial hypercholesterolemia," Reed said, referring to a genetic condition that causes very high LDL levels that often resist statin treatment. Can U.S. Health-Care System Afford New, Improved Cholesterol Drugs? 2015-06-18T04:00:00Z An LDL of 14 and no other health problems. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z According to the Mayo Clinic, trans fats raise LDL, or “bad,” cholesterol, and lower HDL, or “good,” cholesterol. Trans fats already out of most food products, companies say 2015-06-16T04:00:00Z However, it has been found that PHOs turn into sludge in arteries, lowering “good” HDL cholesterol and raising “bad” LDL cholesterol, leading to heart attacks, strokes and other serious health problems. FDA bans trans fats in the U.S.: Which foods have them 2015-06-16T04:00:00Z Consuming trans fats simultaneously increases "bad" LDL cholesterol and drives down "good" HDL cholesterol in a person's bloodstream. FDA Tells Food Industry to Stop Using Artificial Trans Fats 2015-06-16T04:00:00Z According to the Mayo Clinic, trans fats raise LDL, or “bad,” cholesterol, and lowers HDL, or “good,” cholesterol. Food industry ordered to phase out artificial trans fats 2015-06-16T04:00:00Z Even more encouraging, in all of the people with the mutations and lower LDL levels, there didn’t seem to be any significant side effects. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z They have LDL levels that can soar as high as five times the normal level and they die young from heart attacks. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z Praluent works by blocking a protein called PCSK9 that normally stops the liver from being able to fully clear LDL cholesterol from the bloodstream. FDA panel recommends approving new drug that dramatically lowers cholesterol 2015-06-09T04:00:00Z “They almost never get vascular disease and tolerate their low levels of LDL very well. So they were the inspiration for developing drugs that inhibit PCSK9.” The Next Big Drug to Treat Heart Disease 2015-06-09T04:00:00Z A recent review of 24 clinical trials -- published April 28 in the Annals of Internal Medicine -- found that PCSK9 inhibitors lowered people's LDL cholesterol by about 47 percent, on average. FDA Advisers Weigh 2 New Cholesterol Drugs 2015-06-09T04:00:00Z That contributed to an unprecedented low level of LDL cholesterol as well. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z Cardiologists generally attempt to get LDL levels to 70 in people at high risk, although many cannot reach that goal. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z But what is the effect on the body when someone with previously dangerous levels drops down to such a low LDL level? FDA panel recommends approving new drug that dramatically lowers cholesterol 2015-06-09T04:00:00Z Further studies of the drugs that mimicked the effect of the genetic mutation showed that almost everyone taking them enjoyed a drop in LDL cholesterol levels of up to 65%. The Next Big Drug to Treat Heart Disease 2015-06-09T04:00:00Z Would it be better to start much earlier in someone whose LDL levels are high? Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z They homed in on those with the highest and lowest levels of LDL cholesterol, and sequenced their genomes to see if any patterns emerged. This New FDA-Approved Cholesterol Drug Is a Game Changer 2015-07-24T04:00:00Z The Amgen drug can get LDL to 20, 15 or even lower. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z The new drugs are considered the first major advance in lowering bad, or LDL, cholesterol in more than 20 years, and analysts expect them to generate billions in sales. Business Highlights 2015-06-08T04:00:00Z The new drugs are considered the first major advance in lowering bad, or LDL, cholesterol in more than 20 years. FDA weighs best patient group for Amgen cholesterol drug 2015-06-08T04:00:00Z If drugs were restricted to those with dangerously high cholesterol levels who cannot get their LDL low enough with statins, the cost would be $16 billion, he estimated. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z Both new drugs lower low-density lipoprotein, or LDL, cholesterol more powerfully and in a different way than existing drugs. Food and Drug Administration Weighs Approval of First-in-Class Cholesterol Drug 2015-06-05T04:00:00Z Studies have consistently found that elevated levels of LDL cholesterol are a major risk factor for heart disease and that risk drops in lock step with declines in LDL. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z The excitement is being generated by the powerful LDL cholesterol lowering properties of these drugs. For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z Both drugs belong to a new class of antibodies that target PCSK9, a protein that maintains "bad" LDL cholesterol in the blood, and are aimed at the millions of people who don't benefit from statins. Fight over hot new cholesterol drugs may be won in milligrams 2015-05-26T04:00:00Z People who have taken them have seen their LDL cholesterol, the so-called bad cholesterol, plunge to remarkably low levels. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z Other studies show that diets with nuts reduce LDL, or “bad,” cholesterol levels by up to 20%. 15 Eating Habits That Make You Live Longer 2015-05-23T04:00:00Z The drug lowers LDL levels by 55 to 75 percent even if the starting point is at a level that was already reduced by a statin. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z This argument hinges on the belief that long term outcome studies, that are now underway for all PCSK-9 inhibitors, indeed show that fewer heart attacks and strokes are observed at lower LDL levels. For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z In March, new clinical trial data showed that both Repatha and Praluent, combined with statins, reduced LDL levels dramatically, cutting in half the risk for heart attack, stroke, and other major cardiovascular problems. Fight over hot new cholesterol drugs may be won in milligrams 2015-05-26T04:00:00Z Lowering LDL cholesterol has generally been found to protect against heart disease. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z Still, research shows some patients, who don’t see high LDL knocked down enough by statins alone, appear to benefit from also taking PCSK9 inhibitors. Nonstatin Cholesterol-Lowering Drugs Show Promise 2015-05-14T04:00:00Z Very few people who have both gene copies disabled ended up with LDL levels of 15 or lower and seem perfectly healthy. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z It is still unclear as to whether the benefits of lowering LDL plateau at some point. For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z Fonarow cautioned that researchers also haven't proven that lowering triglycerides -- but not "bad" LDL cholesterol -- will lower the risk of heart problems. Americans' Blood Triglyceride Levels Dropping: CDC 2015-05-07T04:00:00Z LDL cholesterol levels plunge by about 40 to 65 percent, even if the starting level was achieved with a statin, the mainstay drug for cholesterol lowering first introduced in the late 1980s. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z The review of 24 clinical trials found that PCSK9 inhibitors lowered people's LDL cholesterol by about 47 percent, on average. New Drug Class Slashes 'Bad' Cholesterol, Review Finds 2015-04-27T04:00:00Z And, he added, the very low LDL levels are so unprecedented, that “it would be cavalier to assume that nothing could possibly go wrong.” Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z However, there are some patients who are unable to tolerate statins and others for whom statins are not powerful enough to lower their LDL to recommended levels. For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z Like the bad type of cholesterol -- LDL -- high levels of triglycerides raise the risk of clogged arteries and heart disease. Americans' Blood Triglyceride Levels Dropping: CDC 2015-05-07T04:00:00Z Doctors often aim for LDL levels of 70 for people at high risk. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z PCSK9 inhibitors work by blocking a protein in the liver that helps regulate LDL, according to the study. New Drug Class Slashes 'Bad' Cholesterol, Review Finds 2015-04-27T04:00:00Z Amgen said it saw no sign of adverse effects with very low LDL levels and is offering only one drug dose. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z This new era of LDL lowering treatment is causing both excitement and concern. For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z Then, studying 12 risk factors, they found that two were related to genes regulating height: LDL or bad cholesterol, and triglycerides, another type of fat in the blood. The gene for short stature is linked to heart disease 2015-04-13T04:00:00Z One had an LDL level of 14 and the other’s was 15. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z For obvious reasons, he kept himself in reasonably good shape, tried to eat well, kept his weight down and took a statin to keep his LDL cholesterol below 100. Mark Cuban -- Health Guru Or Irresponsible Billionaire? 2015-04-06T04:00:00Z Sanofi and Regeneron, whose drug was considered on Tuesday, said it discontinued treatment with its drug or reduced the dose when people’s LDL levels got below 25. Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z Is there a difference in cardiovascular risk between a heart patient with an LDL of 60 mg/dL vs. a patient with an LDL of 45 mg/dL? For The Pricing Of New Cholesterol Lowering PCSK-9 Drugs, Does Dose Size Matter? 2015-06-01T04:00:00Z After roughly six months, researchers saw LDL levels drop by 62 percent for those on the drug, compared with those on a placebo. Amgen, Regeneron Stocks Go Up as Drugs Bring Cholesterol Down 2015-03-16T04:00:00Z That indicated that it might be safe to block the action of the gene with a drug and drive LDL levels very low. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z He said that there was no correlation between the neurocognitive events and the degree of LDL reduction achieved. Should You Be Worried About The Neurocognitive Side Effects Of The New Cholesterol Drugs? 2015-03-16T04:00:00Z “On the other hand, there is not much data that having an LDL less than 40 shows much benefit. It’s a real conundrum. I don’t know what the answer is.” Panel Tells F.D.A. to Back Second Drug to Help Heart 2015-06-10T04:00:00Z They lower LDL or bad cholesterol more powerfully and in a different way than existing drugs, by blocking PCSK9, a substance that interferes with the liver's ability to remove cholesterol from the blood. Studies boost hopes for new class of cholesterol medicines 2015-03-15T04:00:00Z Statins reduce cardiovascular risk and scientists believe it is because they decrease low-density lipoprotein, or LDL, the so-called bad cholesterol. Tests of Cholesterol Drugs Offer Hope of Reducing Heart Attacks and Strokes 2015-03-15T04:00:00Z The evidence so far says lower is better and that there is no known point at which the increasing benefits of dropping LDL levels even out. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z This would suggest that very low levels of LDL by itself would not lead to neurocognitive problems. Should You Be Worried About The Neurocognitive Side Effects Of The New Cholesterol Drugs? 2015-03-16T04:00:00Z On the one hand the very early data suggests that the LDL lowering effect may result in a substantial cardiovascular benefit. New Cholesterol Drugs: Highly Effective But Important Questions Remain 2015-03-15T04:00:00Z However, coffee may increase LDL cholesterol, affect pregnancy outcomes and increase anxiety and blood pressure, Heller said. Love Coffee? Your Heart May, Too 2015-03-02T05:00:00Z Most patients saw significant decreases in LDL cholesterol. Poor Response to Statins May Mean Clogged Arteries 2015-02-26T05:00:00Z Some people in the clinical trials, in fact, have gotten their LDL levels into the 20s. Federal Panel Weighs Approving Two New Cholesterol Drugs 2015-06-09T04:00:00Z HDL and LDL are actually carriers of cholesterol called lipoproteins. 5 Things You Should Know About Cholesterol 2015-02-26T05:00:00Z Both lowered LDL cholesterol powerfully, which is what the drugs were designed to do. New Cholesterol Drugs: Highly Effective But Important Questions Remain 2015-03-15T04:00:00Z A large number of metabolic trait variants are enriched in liver enhancer marks, including LDL, HDL, total cholesterol, lipid metabolism phenotypes, and metabolite levels83, 84. Integrative analysis of 111 reference human epigenomes : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Fonarow said new drugs to lower LDL cholesterol are being tested in large clinical trials. Poor Response to Statins May Mean Clogged Arteries 2015-02-26T05:00:00Z Most of the variants involved logical processes such as the formation of HDL and LDL cholesterol, triglycerides and processing of insulin. The Future of Obesity Treatment Could Get Personal 2015-02-11T05:00:00Z Studies also show that people who add beans to their diet lower heart-harmful LDL cholesterol in a matter of weeks. 5 Foods That Won’t Break Your Heart 2015-02-10T05:00:00Z But anacetrapib is lowering LDL cholesterol via a new, undefined mechanism and its relevance to cardiovascular medicine remains to be proven. Forget HDL, Merck Is Banking On LDL For Its Heart Drug, Anacetrapib 2015-02-05T05:00:00Z They defined high cholesterol very conservatively in this study, pegging it at about 130 mg/dL of "bad" LDL cholesterol, a level which the U.S. Prolonged High Cholesterol in Middle Age Raises Heart Risk Later: Study 2015-01-26T05:00:00Z However, for 20 percent of the patients, LDL cholesterol levels either decreased only a little, remained the same or increased. Poor Response to Statins May Mean Clogged Arteries 2015-02-26T05:00:00Z In the study, the researchers considered LDL levels above 130 mg/dL as elevated, which falls into line with previous professional heart organization criteria. High Cholesterol Can Be Dangerous Even at Age 35 2015-01-26T05:00:00Z The drug, alirocumab, belongs to an emerging class of injectable drugs that block a naturally occurring protein called PCSK9, which inhibits the liver from expelling "bad" LDL cholesterol. UPDATE 2-Sanofi, Regeneron cholesterol drug also effective in monthly doses 2015-01-09T05:00:00Z They are resting all their hopes on the enhanced LDL cholesterol lowering capacity of anacetrapib which, when combined with a statin, is superior to a statin alone. Forget HDL, Merck Is Banking On LDL For Its Heart Drug, Anacetrapib 2015-02-05T05:00:00Z Do the actions we recommend above, and also strive for normal blood pressure and LDL cholesterol levels. Why Rationing Preventive Services By Age is a Mistake 2014-12-08T05:00:00Z He agreed that the findings of this study "suggest it may be important for evaluating clinical response to monitor LDL reduction during statin therapy." Poor Response to Statins May Mean Clogged Arteries 2015-02-26T05:00:00Z But the new study appeared to show that an LDL as low as 60 was preferential in preventing a cardiac event, which may impact future AHA guidelines. Cholesterol and Your Heart 2014-11-22T05:00:00Z It will be interesting to see how the FDA will respond to other experimental LDL lowering agents. Do The IMPROVE-IT Results Offer Promise For Another Merck Heart Drug - Anacetrapib? 2014-11-21T05:00:00Z Theoretically, this added boost in lowering LDL cholesterol should in turn reduce cardiovascular events. Forget HDL, Merck Is Banking On LDL For Its Heart Drug, Anacetrapib 2015-02-05T05:00:00Z Could unanticipated toxicities result from sustained LDL levels at levels below 40mg/dL? Will The IMPROVE-IT Results Impact The Thinking Of The FDA And Payers On LDL-Cholesterol Lowering Drugs? 2014-11-19T05:00:00Z Statins, which lower the amount of LDL or bad cholesterol in the blood, are considered a kind of miracle drug in modern medicine. Cholesterol drug Vytorin may actually work, new data shows “The study affirms the central role of intensive LDL reduction in the prevention of recurrent cardiovascular events,” says Neil Stone, a cardiologist at Northwestern University in Chicago, who was not involved with the study. Drug trial supports importance of low cholesterol to treat heart disease 2014-11-16T05:00:00Z This trial's finding that alirocumab was more effective at lowering LDL cholesterol than Zetia is particularly interesting given the results of another study -- also presented Monday -- on Zetia combined with a statin. Experimental Cholesterol-Lowering Drug Effective, Study Reports 2014-11-17T05:00:00Z Cannon added that the trial “reaffirms the LDL hypothesis, that reducing LDL prevents cardiovascular events” and that the results should be incorporated in future guidelines. IMPROVE-IT Meets Endpoint and Demonstrates Real But Modest Clinical Benefit for Ezetimibe 2014-11-17T05:00:00Z Are we reaching a point where further LDL lowering will not provide added benefit? Will The IMPROVE-IT Results Impact The Thinking Of The FDA And Payers On LDL-Cholesterol Lowering Drugs? 2014-11-19T05:00:00Z The result was a 50 percent reduction in cholesterol absorption — the same as produced by ezetimibe — and an LDL reduction of 12 milligrams per deciliter of blood, also the same amount as produced by ezetimide. Study Finds Alternative to Statins in Preventing Heart Attacks and Strokes 2014-11-17T05:00:00Z This study won’t completely settle this issue, but it does mean that scientists and doctors will assume that cutting LDL means preventing heart attacks and strokes. After Years Under Attack, Merck's Vytorin Proves Effective 2014-11-17T05:00:00Z Zetia prevents absorption of LDL cholesterol in food by the intestines. Experimental Cholesterol-Lowering Drug Effective, Study Reports 2014-11-17T05:00:00Z A very large genetic study published in the New England Journal of Medicine offers compelling evidence in support of a central role for LDL cholesterol in coronary heart disease. Newly Identified Gene Mutations Act Like a Lifetime of Treatment with Merck Cholesterol Drug 2014-11-13T05:00:00Z First, in IMPROVE-IT, the drop in LDL from 70 to 53 is pretty substantial. Will The IMPROVE-IT Results Impact The Thinking Of The FDA And Payers On LDL-Cholesterol Lowering Drugs? 2014-11-19T05:00:00Z When Zetia was designed, scientists knew how it worked to lower LDL, or bad cholesterol, and it won federal approval based on its ability to do that. Gene study boosts interest in heart drug Zetia 2014-11-12T05:00:00Z Researchers found that people with rare mutations that switch off a single copy of a gene called NPC1L1 are protected against high levels of "bad" LDL cholesterol and narrowing of the heart's arteries. Researchers Find Gene Mutation That May Protect Against Heart Disease 2014-11-12T05:00:00Z It improves the removal of LDL cholesterol from the bloodstream by blocking a protein that normally stops the body from getting rid of LDL, according to the researchers. Experimental Cholesterol-Lowering Drug Effective, Study Reports 2014-11-17T05:00:00Z Indeed, many of the so-called “pleiotropic” effects may be a direct effect of lowering LDL. Newly Identified Gene Mutations Act Like a Lifetime of Treatment with Merck Cholesterol Drug 2014-11-13T05:00:00Z Given that “lower is better”, one would think that these agents would be a lock for rapid FDA approval based on their profound LDL lowering properties. Will The IMPROVE-IT Results Impact The Thinking Of The FDA And Payers On LDL-Cholesterol Lowering Drugs? 2014-11-19T05:00:00Z Critics of the drug noted that, despite its success, there were no trials showing the drug conferred any actual clinical benefit besides lowering LDL. What You Need To Know About IMPROVE-IT 2014-11-07T05:00:00Z Those with established high cholesterol given the same supplement experienced a 12 percent drop in LDL. 8 Surprising Health Benefits of Red Wine 2014-10-30T04:00:00Z Now, however, a new genetic study published in JAMA suggests that LDL cholesterol may in fact cause an increase in aortic valve calcium and aortic valve stenosis. Genetic Study Suggests Possible Causal Role for Cholesterol In Heart Valve Disease 2014-10-26T04:00:00Z Initial in vitro studies suggested the peptide formed HDL-like particles and sopped up LDL, an encouraging result that prompted them to push it further. Would-be drug mimics 'good' cholesterol 2014-10-16T04:00:00Z This is important because this ratio seems to predict heart disease risk even better than LDL levels alone, Riserus said. If You Do Gain Weight, Polyunsaturated Fats May Prevent Some Damage 2014-10-16T04:00:00Z These receptors then remove LDL from the blood. What You Need To Know About IMPROVE-IT 2014-11-07T05:00:00Z Here is the change in LDL over 12 weeks: Cholesterol Drugs Haunted By Ghosts Of Past, Present, And Future 2014-10-02T04:00:00Z Clinic care managers run weekly reports showing which of 14,000 patients with diabetes are overdue to get their hemoglobin A1C, LDL and blood pressure levels checked. Hospital of Tomorrow Will Be 'Dynamic System' 2014-09-09T04:00:00Z Blood pressure, total cholesterol and LDL, the so-called bad cholesterol, stayed about the same for people in each group. A Call for a Low-Carb Diet 2014-09-01T04:00:00Z LDL levels between the groups differed by 9 percent. If You Do Gain Weight, Polyunsaturated Fats May Prevent Some Damage 2014-10-16T04:00:00Z People in the low-carb group ate more monounsaturated fat and even more saturated fat than they did before their diet, but still saw a drop in LDL cholesterol. For Weight Loss, Low-Carb Diet Beats Low-Fat 2014-09-01T04:00:00Z And it will also provide the first real evidence in the modern era about the role of LDL as a surrogate endpoint. Cholesterol Drugs Haunted By Ghosts Of Past, Present, And Future 2014-10-02T04:00:00Z So far, more than half of the people in the program who started off with above-normal blood pressure have lowered it significantly, and those with high LDL cholesterol levels have seen reductions averaging 15 points. Hospital of Tomorrow Will Be 'Dynamic System' 2014-09-09T04:00:00Z One important predictor of heart disease that the study did not assess, Dr. Sniderman said, was the relative size and number of LDL particles in the bloodstream. A Call for a Low-Carb Diet 2014-09-01T04:00:00Z They lower LDL, the so-called bad cholesterol, in a new way and are expected to reap multibillion-dollar sales. Cholesterol Drug Halves Heart Attack and Stroke in Early Test 2014-08-31T04:00:00Z Select products that contain no trans fats, which raise levels of bad LDL cholesterol and lower levels of good HDL cholesterol, Blakely added. Read Food Labels to Combat Childhood Obesity 2014-08-22T04:00:00Z So IMPROVE-IT will provide vital new raw material to the debate about the reliability of surrogate endpoints in general and the independent importance of lowering LDL cholesterol in particular. Cholesterol Drugs Haunted By Ghosts Of Past, Present, And Future 2014-10-02T04:00:00Z It found that people who ate a diet rich in meat, soda and fried and fast foods, including instant noodles, were associated with an increase in abdominal obesity and LDL, or “bad,” cholesterol. Noodles: Friend or foe? S. Koreans defend diet 2014-08-21T04:00:00Z Eating refined carbohydrates tends to raise the overall number of LDL particles and shift them toward the small, dense variety, which contributes to atherosclerosis. A Call for a Low-Carb Diet 2014-09-01T04:00:00Z Compounds called cafestol, present in coffee beans, appear to raise LDL cholesterol—though paper filters eliminate most of those compound, making it more of a concern with French press and espresso-style brews. Is Coffee Bad for You? 2014-08-20T04:00:00Z It is widely believed that the trial will provide a significant contribution to the debate about the reliability of surrogate endpoints in general and the independent importance of lowering LDL cholesterol in particular. IMPROVE-IT Trial Scheduled For Presentation In November 2014-08-12T04:00:00Z Under the previous guidelines, healthy people were advised to keep total cholesterol under 200 milligrams per deciliter and their LDL to a max of 160; 130 to 159 was borderline. Should You Be Taking a Statin? 2014-08-12T04:00:00Z Dr. Williams became a vegan in 2003 because he was concerned that his LDL cholesterol — the kind associated with an increased risk of heart disease — was too high. Advice From a Vegan Cardiologist 2014-08-06T04:00:00Z High-density lipoprotein or HDL cholesterol is the hero, removing bad LDL from the blood and sending it to the liver, where it’s treated as waste. Keeping Your Cholesterol in Check 2014-07-30T04:00:00Z Those include a lowering of blood levels of LDL "bad" cholesterol and helping to control blood sugar and reduce insulin resistance -- a key player in diabetes. Could Probiotics Help Tame High Blood Pressure? 2014-07-21T04:00:00Z For example, use of cholesterol-lowering medications increased from just under 4 percent to nearly 13 percent over time in these patients, with an accompanying decline in "bad" LDL cholesterol levels. Stroke Rates Declining Among Seniors, Study Shows 2014-07-15T04:00:00Z Anyone with heart disease was encouraged to bring the LDL number down to less than 100; whittling it down to 70 was even better. Should You Be Taking a Statin? 2014-08-12T04:00:00Z Although LDL plays a role in heart disease, it is not the only factor. Advice From a Vegan Cardiologist 2014-08-06T04:00:00Z There’s more than one type of cholesterol: Low-density lipoprotein or LDL cholesterol is the bad guy. Keeping Your Cholesterol in Check 2014-07-30T04:00:00Z Higher readings of LDL, total cholesterol and triglycerides did, as expected, correlate with higher risk for heart disease and death. Doubts on Fasting Before Cholesterol Tests 2014-07-11T04:00:00Z Low-density lipoprotein, or LDL cholesterol, targeted by changes in diet and popular statin drugs, remains public enemy number one. Mutations That Prevent Heart Attacks Upend The Search For New Drugs 2014-06-19T04:00:00Z Now, he added, “there is a route to heart attacks that is independent of LDL,” referring to the form of cholesterol associated with heart disease. Scientists Identify Mutations That Protect Against Heart Attacks 2014-06-18T04:00:00Z In a healthy cardiovascular system, LDL, HDL and triglycerides are in balance. You probably know less about cholesterol than you think you do. Here’s some help. One goal in controlling cholesterol is keeping LDL and triglyceride levels low, while making sure HDL levels stay high enough. Keeping Your Cholesterol in Check 2014-07-30T04:00:00Z With less of the protein around, less LDL remains in the blood; those with the PCSK9 mutation showed as much as an 88% lower risk of heart disease compared to people without the genetic change. A Vaccine Against Heart Disease? It's Possible 2014-06-11T04:00:00Z The American Academy of Pediatrics released guidelines a number of years ago recommending that children as young as 8 years old be treated with medication for an LDL cholesterol level above 190. Calling an Ordinary Health Problem a Disease Leads to Bigger Problems 2014-06-02T04:00:00Z The next big price battle centers on a new class of cholesterol drugs known as PCSK9 inhibitors, which help the liver to clear “bad” LDL cholesterol from the blood. Insurers scrutinize drug costs after $84,000 Sovaldi surprise 2014-05-28T04:00:00Z As expected, LDL levels were lower in the simvastatin group. Disappointing Results For Statins In Two NIH Trials 2014-05-18T04:00:00Z The antibodies in evolocumab are designed to intercept PCSK9, preventing the protein from breaking down the cells' LDL receptors, which allows them to stay in circulation longer to remove LDL cholesterol, she explained. New Drug May Help Lower 'Bad' Cholesterol Beyond Statins 2014-05-13T04:00:00Z Eating modest amounts of legumes — peas, chickpeas, beans and lentils — appears to reduce levels of LDL, the so-called bad cholesterol. Well: Beans and Peas Lower Cholesterol 2014-04-14T16:05:54Z Evolocumab belongs to a highly promising class of drugs called PCSK9 inhibitors that block a protein that reduces the liver's ability to remove LDL from the blood. Amgen drug lowers cholesterol up to 66 percent in pivotal studies 2014-03-29T18:02:25Z LDL or “bad cholesterol” was borderline or too high in 46 percent, and HDL or “good” cholesterol was borderline or too low in 44 percent. Study Finds Many Preteens Have High Cholesterol 2014-03-28T13:47:05Z LDL or "bad cholesterol" was borderline or too high in 46 percent, and HDL or "good" cholesterol was borderline or too low in 44 percent. Study finds many preteens have high cholesterol 2014-03-28T13:01:11Z Compared with the placebo, evolocumab taken every two weeks reduced LDL cholesterol levels an additional 66 percent to 75 percent, and taken monthly cut the level by 63 percent to 75 percent. New Drug May Help Lower 'Bad' Cholesterol Beyond Statins 2014-05-13T04:00:00Z Lowering LDL by that amount suggests a 5 percent to 6 percent reduction in heart attacks and other major cardiovascular events, the researchers write. Well: Beans and Peas Lower Cholesterol 2014-04-14T16:05:54Z It also helped about 70 percent of patients get their LDL down to 70 or lower, Koren said. Amgen drug lowers cholesterol up to 66 percent in pivotal studies 2014-03-29T18:02:25Z |
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