| 单词 | kinase |
| 例句 | “He has very high levels of creatine kinase … this points to muscular dystrophy … and by virtue of his age and sex, it’s statistically most likely he has Duchenne.” Our beautiful sons could die before us 2014-08-16T04:00:00Z However, the benefits of refeeding after fasting in old killifish can be restored by genetically activating a specific subunit of AMP kinase, an important sensor of cellular energy. Cycle of fasting and feeding is crucial for healthy aging 2023-11-13T05:00:00Z When they recognise these fragments, they start the 'fight back' response by activating the RIPK2 kinase. A promising target to fight inflammatory bowel diseases 2023-10-26T04:00:00Z Ruptured cells release enzymes called creatine kinases, which can damage tissues. The Theory That Men Evolved to Hunt and Women Evolved to Gather Is Wrong 2023-10-17T04:00:00Z The research has revealed how the attack protein is controlled through a process called phosphorylation, a process in which a phosphate group is added to a protein by enzymes called protein kinases. New discovery may 'unlock' the future of infectious disease and cancer treatment 2023-10-05T04:00:00Z Osimertinib is what scientists call a tyrosine kinase inhibitor, a substance that affects a class of enzymes involved in cell signaling, growth and division. Lung Cancer Pill Halves Risk of Death in Some People 2023-06-08T04:00:00Z These mutant fish experienced improved health and longevity, indicating that both fasting and refeeding are needed to confer health benefits and act through AMP kinase to do so. Cycle of fasting and feeding is crucial for healthy aging 2023-11-13T05:00:00Z "A drug targeting this kinase would block this signalling pathway without affecting other cellular processes." A promising target to fight inflammatory bowel diseases 2023-10-26T04:00:00Z An example of a protein that regulates translation in the nucleus is the MAP kinase ERK. Biology for AP Courses 2022-06-09T00:00:00Z His work showed that the coronavirus increases production of the enzyme casein kinase II, which in turn helps build the protein backbone of filopodia and nanotubes. COVID Virus May Tunnel through Nanotubes from Nose to Brain 2022-07-20T04:00:00Z However, insulin appears to activate a tyrosine kinase receptor, triggering the phosphorylation of many substrates within the cell. Anatomy and Physiology 2013-06-19T00:00:00Z When the researchers looked more closely at how the fatty tissue of the old fish differed from that of the young, they came across a specific protein called AMP kinase. Cycle of fasting and feeding is crucial for healthy aging 2023-11-13T05:00:00Z Turning Point's lead asset is repotrectiniba that belongs to a class of treatments called tyrosine kinase inhibitors. Bristol Myers to buy Turning Point Therapeutics for $4.1 bln 2022-06-03T04:00:00Z Most growth factors bind to cell-surface receptors that are linked to tyrosine kinases. Biology for AP Courses 2022-06-09T00:00:00Z Still, he would put a hold on the medication and order a test to look for creatine kinase, another protein released by injured muscles. Months After a Stroke, the Man Was Wasting Away. What Was Wrong? 2022-05-26T04:00:00Z This reaction is catalyzed by the enzyme creatine kinase and occurs very quickly; thus, creatine phosphate-derived ATP powers the first few seconds of muscle contraction. Anatomy and Physiology 2013-06-19T00:00:00Z This kinase is a cellular energy sensor, and is made up of different subunits, of which the activity of the γ1 subunit decreases with age. Cycle of fasting and feeding is crucial for healthy aging 2023-11-13T05:00:00Z Chemotherapy on its own was also tied to high rates of psychiatric disorders, whereas “kinase inhibitors” — targeted drugs that often have fewer side effects — had the lowest rates. Cancer Patients Are at High Risk of Depression and Suicide, Studies Find 2022-03-28T04:00:00Z Activation of RTKs initiates a signaling pathway that includes a G-protein called RAS, which activates the MAP kinase pathway described earlier. Biology for AP Courses 2022-06-09T00:00:00Z Baricitinib inhibits enzymes in the Janus kinase family, which play an important role in regulating immune responses. News at a glance: Hong Kong’s high COVID-19 death rate, Biden’s ‘test and treat,’ and a ResearchGate lawsuit 2022-03-09T05:00:00Z Some smooth muscle can also maintain contractions even as Ca++ is removed and myosin kinase is inactivated/dephosphorylated. Anatomy and Physiology 2013-06-19T00:00:00Z An enzyme called salt-inducible kinase 3 provides a direct link between sleep and metabolism. ‘If it’s alive, it sleeps.’ Brainless creatures shed light on why we slumber 2021-10-27T04:00:00Z That signal involves the production of a type of cytokine called a Janus kinase, or JAK. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z The peptide-based molecules bind kinases and initiate signaling cascades in the cells. Biology for AP Courses 2022-06-09T00:00:00Z As a student, Sabatini discovered the mTOR kinase signaling pathway, a central regulator of growth and aging that doesn’t function properly in common diseases including cancer. MIT and HHMI fire prominent biologist for sexual harassment 2021-08-21T04:00:00Z In the final step, these protein kinases phosphorylate proteins in the cytoplasm. Anatomy and Physiology 2013-06-19T00:00:00Z A normal level of creatine kinase is in the 100 to 200 range. He Thought It Was the Flu, but He Had Never Been So Sick 2021-07-14T04:00:00Z That strategy worked for so-called kinase inhibitors, which also block a protein created by gene mutations. How scientists shot down cancer’s ‘Death Star’ 2021-02-05T05:00:00Z The mouse genome includes one gene and two pseudogenes for cytoplasmic thymidine kinase. Biology for AP Courses 2022-06-09T00:00:00Z The complex adds a phosphate group to a cytoplasmic kinase called BIK1. Calcium channel in plants helps shut the door on intruders 2020-09-06T04:00:00Z The effects vary according to the type of target cell, the G proteins and kinases involved, and the phosphorylation of proteins. Anatomy and Physiology 2013-06-19T00:00:00Z Over the last few months, we built a second, more detailed map looking specifically for the kinases that the coronavirus is hijacking. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z There are 50 approved kinase inhibitors on the market now. How scientists shot down cancer’s ‘Death Star’ 2021-02-05T05:00:00Z This AMP-activated kinase is coupled with mitochondrial oxidative phosphorylation to detect reduced oxygen and signal the RCs of the medulla directly—a distributed network for detection and response. Biology for AP Courses 2022-06-09T00:00:00Z One enduring mystery has been whether mitochondrial dysfunction also directly regulates kinase enzymes in the cytosol that are needed for the ISR, and that act by adding a phosphate group to proteins. Mitochondrial distress call moves to the cytosol to trigger a response to stress 2020-03-03T05:00:00Z Like cAMP, DAG activates protein kinases that initiate a phosphorylation cascade. Anatomy and Physiology 2013-06-19T00:00:00Z This map shows how the coronavirus changes the function of kinases – cellular switches involved in most biological processes – and the proteins they control. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z Moreover, mice and cell lines lacking DNA-PKcs kinase activity showed reduced global protein synthesis. DNA-repair enzyme turns to translation 2020-02-25T05:00:00Z Scientists have taken advantage of that fact by blocking pyruvate kinase in some deadly parasites, such as the ones that cause African Sleeping Sickness and Chagas disease. Biology for AP Courses 2022-06-09T00:00:00Z Tanzi and his colleagues blocked a variety of different enzymes called kinases to try to stop the process. Possible Missing Link in Alzheimer’s Pathology Identified 2020-01-16T05:00:00Z Upon binding calcium, calmodulin is able to modulate protein kinase within the cell. Anatomy and Physiology 2013-06-19T00:00:00Z There are 518 human kinases, and they act as major control hubs for virtually all processes in the body. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z The inhibitor is in the same class of compounds—known as Rho kinase inhibitors—as the drug Ripasudil, which is used in Japan to treat glaucoma and other eye-related conditions. Lymph vessels on a chip reveal possible new drug target for lymphedema 2019-12-13T05:00:00Z A kinase is an enzyme that transfers phosphate groups from ATP to another protein. Biology for AP Courses 2022-06-09T00:00:00Z NGF does this by binding to tyrosine kinase receptor A, which triggers a cascade of effects that include boosting the number of pain receptors and sensitizing nerves. Analgesia without opioids 2019-09-10T04:00:00Z The protein p21 is probably best known for its role in blocking cell division by inhibiting protein complexes called cyclin-dependent kinases. A dynamic view of chemotherapy effectiveness 2019-08-04T04:00:00Z We then compared the two, and by looking at the differences between the infected and uninfected lists, we were able to determine which kinases the coronavirus uses to reproduce. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z The researchers used CAGE-prox not only to activate diverse protein structures, but also to control the sensitivity of kinase enzymes to inhibitors, thereby allowing modified and wild-type kinases to be inhibited independently. An ‘on’ switch for proteins 2019-05-07T04:00:00Z First, signaling molecules bind to the extracellular domain of two nearby tyrosine kinase receptors. Biology for AP Courses 2022-06-09T00:00:00Z Another key observation made by Walter and colleagues is that tumours that lack Rb do not upregulate a signalling pathway containing the kinase MAPK, which is often activated in lung adenocarcinoma. Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets 2019-04-30T04:00:00Z “This gives you a lot of power to study oncogenes and kinases and proteins that have very rapid activity.” Protein-slaying drugs could be the next blockbuster therapies 2019-03-19T04:00:00Z Of those 97 kinases, we found 49 that the virus affects. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z “The tumors were completely lacking the presence of this protein; typically tumors show high amounts of this kinase.” How prostate cancer becomes resistant to treatment 2019-03-08T05:00:00Z A significant contributor to cell signaling cascades is the phosphorylation of molecules by enzymes known as kinases. Biology for AP Courses 2022-06-09T00:00:00Z This includes examining creatine kinase to assess muscle damage and high-sensitivity C-reactive protein to measure inflammation — two areas of particular concern for basketball players because of the nature of their on-court movements. The Mavericks’ Key to Keeping Players Fresh? Blood Samples 2019-01-07T05:00:00Z We identified an enzyme called protein kinase CK2 that causes normal cells to divide in the developing cerebellum by activating hedgehog signaling. Drug development is no longer just for Big Pharma. Researchers at Bio-X explain 2019-01-02T05:00:00Z While identifying the kinases involved in SARS-CoV-2 replication, we were also able to learn a lot about how the virus changes our bodies. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z Decades ago, Cantley discovered an enzyme named PI3 kinase, which regulates the growth and survival of cells in the presence of nutrients. It’s Time to Study Whether Eating Particular Diets Can Help Heal Us 2018-12-05T05:00:00Z Tyrosine kinase receptors are pairs of proteins that span the plasma membrane. Biology for AP Courses 2022-06-09T00:00:00Z In a clever set of biochemical studies, they showed that nitric oxide modifies specific cysteine residues of pyruvate kinase M2. Metabolism reprogrammed by the nitric oxide signalling molecule 2018-11-27T05:00:00Z And drugs known as Bruton’s tyrosine kinase inhibitors are emerging: these block a molecule in the signalling pathway that turns some white blood cells cancerous. Lymphoma 2018-11-13T05:00:00Z To increase our chances, we also looked for drugs that hit some of the proteins the kinases act on. Coronavirus and cancer hijack the same parts in human cells to spread 2020-07-03T04:00:00Z It would be a novel kind of trial — one in which diet itself would become a drug, or a co-drug, with the PI3 kinase inhibitors. It’s Time to Study Whether Eating Particular Diets Can Help Heal Us 2018-12-05T05:00:00Z The last step in glycolysis will not occur if pyruvate kinase, the enzyme that catalyzes the formation of pyruvate, is not available in sufficient quantities. Biology for AP Courses 2022-06-09T00:00:00Z This is one of the key findings of the study: pyruvate kinase M2 is a target of nitric oxide. Metabolism reprogrammed by the nitric oxide signalling molecule 2018-11-27T05:00:00Z Molecularly targeted agents known as kinase inhibitors might be particularly affected, and a number of companies are working to address the efflux issue in brain-cancer drug candidates, Elmquist says. Getting cancer drugs into the brain 2018-09-25T04:00:00Z In the fruit fly Drosophila melanogaster, there is a gradient of activity of the kinase enzyme Aurora B that is highest near the spindle in the centre of a dividing cell9. A core problem in nuclear assembly 2018-09-18T04:00:00Z The gene encodes a namesake protein that functions as a a type of enzyme called a kinase. Parkinson's Drugs Aimed at Rare Gene Mutation Show Promise for Other Sufferers, Too 2018-08-06T04:00:00Z The kinase and the phosphatase are also regulated. Biology for AP Courses 2022-06-09T00:00:00Z Zhou et al. next genetically engineered mice so that their kidneys did not produce pyruvate kinase. Metabolism reprogrammed by the nitric oxide signalling molecule 2018-11-27T05:00:00Z The authors identified the protein kinase enzyme CRK12 as a target of compound 7. Drug candidate and target for leishmaniasis 2018-07-24T04:00:00Z Choanoflagellates have genes for tyrosine kinases, enzymes that, in complex animals, help control the functions of specialized cells, such as insulin secretion in the pancreas. The momentous transition to multicellular life may not have been so hard after all 2018-06-28T04:00:00Z A protein released when muscles are injured, creatine kinase, was much too high. Had Two Diseases Struck at Once? 2018-05-30T04:00:00Z Further amplification occurs as protein kinases, once activated by cAMP, can catalyze many reactions. Biology for AP Courses 2022-06-09T00:00:00Z The authors found that ischaemia causes less damage in these mice than in wild-type mice, consistent with the idea that pyruvate kinase mediates the protective effects of nitric oxide. Metabolism reprogrammed by the nitric oxide signalling molecule 2018-11-27T05:00:00Z The range of protein kinases in Leishmania is different from that in humans, so this study provides an impetus to search for other ‘druggable’ protein kinases in the parasite7. Drug candidate and target for leishmaniasis 2018-07-24T04:00:00Z Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Pancreas regeneration 2018-05-15T04:00:00Z Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. MEK drives BRAF activation through allosteric control of KSR proteins 2018-02-11T05:00:00Z The transfer of the phosphate is catalyzed by an enzyme called a kinase. Biology for AP Courses 2022-06-09T00:00:00Z The authors therefore conclude that nitric oxide inhibits pyruvate kinase and glycolysis, causing glucose levels to increase. Metabolism reprogrammed by the nitric oxide signalling molecule 2018-11-27T05:00:00Z Suppression of the evolutionarily conserved protein kinase enzyme mTOR, which is at the heart of the nutrient-responsive mTOR signalling pathway, is one of the most thoroughly tested ways to extend lifespan. Longer life through an odd Pol enzyme The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis 2017-11-14T05:00:00Z COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. MEK drives BRAF activation through allosteric control of KSR proteins 2018-02-11T05:00:00Z The peptide autoinducers stimulate more complicated signaling pathways that include bacterial kinases. Biology for AP Courses 2022-06-09T00:00:00Z The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth 2017-11-28T05:00:00Z Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Structure of PINK1 in complex with its substrate ubiquitin 2017-10-29T04:00:00Z Voegele, R. T., Sweet, G. D. & Boos, W. Glycerol kinase of Escherichia coli is activated by interaction with the glycerol facilitator. A global resource allocation strategy governs growth transition kinetics of Escherichia coli 2017-10-24T04:00:00Z At the time PTK7 was what’s called an “orphan receptor tyrosine kinase”—it wasn’t known where it binds in the body. Wanted: More Data, the Dirtier the Better 2017-06-12T04:00:00Z Of the 130 kinase types in yeast, 97 belong to the 55 subfamilies of kinases that are found in other eukaryotic organisms. Biology for AP Courses 2022-06-09T00:00:00Z Tellingly, the combination therapies dramatically reduced the percentage of circulating cells that were derived from the donor mice, suggesting that two-pronged therapies that target both epigenetic dysregulation and kinase signalling can induce potent antileukaemic responses. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. Structure of PINK1 in complex with its substrate ubiquitin 2017-10-29T04:00:00Z Tolerance traits — such as the kinase enzymes that place plant sugars in below-ground storage during attack — are not mentioned in Walters's narrative. Plant science: The plant as pugilist : Nature : Nature Research 2017-02-28T05:00:00Z Subsequent testing revealed some players had high levels of creatine kinase, another indicator. ‘Play until you puke’ mindset needs to change 2017-01-19T05:00:00Z The only obvious deficiency seen in yeasts is the complete absence of tyrosine kinases. Biology for AP Courses 2022-06-09T00:00:00Z These data reveal a potential role for inhibitors of cell cycle kinases for treatment, especially in ESCC. Integrated genomic characterization of oesophageal carcinoma : Nature : Nature Research 2017-01-03T05:00:00Z Taylor, S. S. & Kornev, A. P. Protein kinases: evolution of dynamic regulatory proteins. Structure of PINK1 in complex with its substrate ubiquitin 2017-10-29T04:00:00Z This dietary supplement inhibits, or slows, protein kinase, which is part of a signaling pathway in the brain associated with bipolar disorder, explains Lauren Marangell, a psychiatrist in Houston. Bipolar can be difficult to diagnose and even harder to treat 2016-11-11T05:00:00Z Future studies will be required to define whether and how some of these substrates for LRRK2 kinase activity contribute to PD. Defects in trafficking bridge Parkinson's disease pathology and genetics : Nature : Nature Research 2016-11-08T05:00:00Z The tyrosine kinases evolved before yeast diverged from other eukaryotes, but the other fifty-five subfamilies of kinases evolved after yeast diverged. Biology for AP Courses 2022-06-09T00:00:00Z We found frequent alterations of receptor tyrosine kinases and downstream signalling mediators, particularly in EAC. Integrated genomic characterization of oesophageal carcinoma : Nature : Nature Research 2017-01-03T05:00:00Z The drug belongs to a group of cancer agents called tyrosine kinase inhibitors, which block certain proteins that fuel cancer growth. Cancer Drug Shows Early Promise for Parkinson's Disease 2016-07-12T04:00:00Z Neratinib is a tyrosine kinase inhibitor, which fights cancer by interrupting chemical signals that drive tumor growth. Innovative Trials Produce Promising Breast Cancer Drugs 2016-07-07T04:00:00Z Once the first kinase inhibitor, imatinib, was approved by the FDA in 2001 to treat chronic myeloid leukaemia, researchers began devoting more resources to them. Competition: Unlikely partnerships : Nature : Nature Publishing Group 2016-05-10T04:00:00Z Fifty-five subfamilies of kinases evolved before yeast diverged from other eukaryotes, but the tyrosine kinases evolved after yeast diverged. Biology for AP Courses 2022-06-09T00:00:00Z The receptor tyrosine kinase TYRO3 dampens allergic responses and enhances immunity to intestinal worms. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity | Science 2016-03-31T04:00:00Z Moussa is listed as an inventor on a Georgetown University patent application related to the use of tyrosine kinase inhibitors for treating Parkinson's and other neurodegenerative diseases. Cancer Drug Shows Early Promise for Parkinson's Disease 2016-07-12T04:00:00Z Tumor-initiating cells differentiate to a more benign state when treated with drugs that activate protein kinase A. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability | Science 2016-03-03T05:00:00Z In addition, higher concentrations of a substance called plasma creatine kinase after the race were associated with more muscle pain and soreness. Recovery From Ultramarathon May Take Up to 5 Days 2016-02-26T05:00:00Z All kinases evolved in yeast, but yeast later lost the tyrosine kinases because they do not need them. Biology for AP Courses 2022-06-09T00:00:00Z The receptor tyrosine kinase TYRO3 dampens allergic responses and enhances immunity to intestinal worms. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity | Science 2016-03-31T04:00:00Z It also set off a hunt by drugmakers for a way to put the brakes on the overactive proteins, called cyclin-dependent kinases. The Art of Setting a Drug Price 2015-12-09T05:00:00Z Tumor-initiating cells differentiate to a more benign state when treated with drugs that activate protein kinase A. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability | Science 2016-03-03T05:00:00Z Specifically, components of the Mediator 'Cdk8 kinase' module failed to associate with the rest of the complex. Molecular biology: Mediating transcription and RNA export : Nature : Nature Publishing Group 2015-10-06T04:00:00Z The evolution of tyrosine kinases involved in cellular communication occurred about 2.5 billion years ago. Biology for AP Courses 2022-06-09T00:00:00Z Cabozantinib belongs to a different class of drugs, called tyrosine kinase inhibitors, which block chemical messengers needed for cell growth. 2 New Drugs Prove More Effective Against Kidney Cancer, Studies Find 2015-09-25T04:00:00Z The condition can be detected with a blood test for a muscle enzyme, creatine kinase, that is released by damaged muscles and when it occurs patients must stop statins immediately. New Alternatives to Statins Add to a Quandary on Cholesterol 2015-08-29T04:00:00Z For example, one probe, initially described as inhibiting a particular protein called PI3 kinase, was described more than a decade ago as having potent effects on many other proteins. Scientists unite to warn against flawed chemical reagents 2015-07-20T04:00:00Z Iressa is among a class of drugs called kinase inhibitors, which are designed to block proteins the spur development of cancer cells. Iressa Approved for Specific Late-Stage Lung Cancer 2015-07-13T04:00:00Z A major component of cell signaling cascades is the phosphorylation of molecules by enzymes known as kinases. Biology for AP Courses 2022-06-09T00:00:00Z The oncogenic alterations that entrectinib and many similar tyrosine kinase inhibitors target are present in only a tiny subset of cancer patients. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z Bevacizumab was followed by a string of kinase inhibitors, which block the chemical messages that encourage cell division. Drug development: Mix and match : Nature : Nature Publishing Group 2015-05-12T04:00:00Z For the most part, the company is focused on genetically defined diseases that involve abnormal kinase activation. Blueprint Medicines IPO: More Than A One-Trick Pony 2015-04-30T04:00:00Z Lenvima is from a class of drugs called kinase inhibitors, which block certain proteins that spur the growth of cancer cells. Lenvima Approved for Common Thyroid Cancer 2015-02-13T05:00:00Z There were, in fact, drugs discovered with the help of “automated, high tech approach to discovering drugs” such as the kinase inhibitors approved to treat lung and stomach cancer. Chuck Norris Attacks The Pharmaceutical Industry 2015-01-05T05:00:00Z The activation of any of these tyrosine kinases, as in cancers with alterations to these genes, is associated with aggressive tumor growth and malignant progression. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z The drug, a targeted kinase inhibitor manufactured by Incyte, offers a needed option for some people affected by this serious blood disorder, a type of myeloproliferative disease. For Treatment Of Polycythemia Vera, FDA Approves Jakafi, A Targeted Therapy 2014-12-05T05:00:00Z In those who received oxygen, researchers found elevated levels of two enzymes that are released when the heart muscle is damaged, creatine kinase and troponin. Oxygen May Not Help Heart Attack Victims 2014-11-19T05:00:00Z There is a lot more work required before we understand how receptors signal to G proteins and other cell-signalling and regulatory proteins such as kinases and arrestins. Q&A: Brian Kobilka : Nature : Nature Publishing Group 2014-10-14T04:00:00Z They used the software to read the abstracts of 186,879 papers and produced a list of the most promising kinases for experiments. Computer says “try this” 2014-10-02T04:00:00Z The role of tyrosine kinases and their related genetic abnormalities are already well understood. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z Intriguingly, the exons removed by these alterations encode regions of the kinase domain. Comprehensive molecular characterization of gastric adenocarcinoma : Nature : Nature Publishing Group 2014-07-22T04:00:00Z They also looked at other proteins called kinases—there are more than 500 of them in humans—that act as switches in turning p53 off and on. IBM Watson's Startling Cancer Coup 2014-08-28T04:00:00Z Some lung cancer patients benefit from crizotinib, a drug that blocks a tumor-promoting protein created by a mutated form of the anaplastic lymphoma kinase gene. Calling on Cancer’s A-Team 2014-08-11T04:00:00Z Of the top nine kinases the software picked, seven have subsequently been shown to activate p53. Computer says “try this” 2014-10-02T04:00:00Z Both compounds increased serum creatine kinase levels in mice. Fatal Toxins Found in "Edible" Wild Mushrooms 2014-06-23T04:00:00Z Several companies, including Agios, have studied an enzyme called pyruvate kinase that helps to break down glucose in the Warburg effect. Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z Figure 4: Inverse relationship between SOX10 and receptor tyrosine kinase expression in melanoma. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z In a related Perspective in Science Signaling, Smerdon discusses the insights into the regulation of the kinase mTOR gained from protein crystallography. [Introduction to Special Issue] Going from Strength to Strength 2014-03-06T20:25:38.551Z Instead, ABP1 functions at the cell surface to bind auxin and a family of membrane kinases, thereby activating intracellular guanosine triphosphatases to initiate important developmental changes in cell shape. [Report] Cell Surface ABP1-TMK Auxin-Sensing Complex Activates ROP GTPase Signaling 2014-02-27T19:26:47.729Z The vaccine activated the nutrient deprivation sensor, GCN2 kinase, in dendritic cells. [Report] Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation 2014-01-16T18:57:07.575Z The receptor identified carries an intracellular kinase domain and an extracellular lectin domain. [Report] Identification of a Plant Receptor for Extracellular ATP 2014-01-16T18:56:54.349Z Tofacitinib is a so-called JAK inhibitor, and blocks an enzyme called Janus kinase, that is also associated with inflammation. Pfizer's drug shows mixed results in psoriasis trials 2013-10-09T13:20:32Z Binding of growth factor to the receptor binding site activates the kinase domain on the interior end of the receptor protein. Hallmarks of Cancer 1: Self-Sufficiency in Growth Signals 2013-09-18T13:15:00.663Z The levels of these factors regulate multiple events of the MBT, including the slowing of the cell cycle, the onset of zygotic transcription, and the developmental activation of the kinase Chk1. [Report] Titration of Four Replication Factors Is Essential for the Xenopus laevis Midblastula Transition 2013-08-22T18:26:19.437Z Together, these receptor kinases form the steroid binding site, with the hormone acting as a “molecular glue” that stabilizes the interaction. [Report] Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases 2013-08-22T18:26:17.463Z About ten drugs targeting epigenetic mechanisms are currently in development, but Armstrong predicts that the number may soon rival that of tyrosine kinase inhibitors, by far the most successful class of leukaemia drugs. Epigenetics: Reversible tags 2013-06-26T17:20:55.210Z Unlike imatinib and other tyrosine kinase inhibitors, which target particular molecular markers, these epigenetic drugs may be less precise in their action, Armstrong says. Drug development: Target practice 2013-06-26T17:20:53.647Z The enzymes that add phosphate groups to proteins are known as kinases; enzymes that remove phosphates are known as phosphatases. Hallmarks of Cancer 1: Self-Sufficiency in Growth Signals 2013-09-18T13:15:00.663Z Through work in Schwartz's lab, researchers discovered that these mutations trigger a known cancer pathway called MAP kinase that helps feed the cancer. Drug is a first to help patients with melanoma of the eye 2013-06-01T11:33:47Z Ponatinib is designed to target an abnormal tyrosine kinase that is closely associated with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia. Ariad drug proves effective in curbing chronic leukemia in study 2012-12-09T13:07:15Z Histidine protein kinases: key signal transducers outside the animal kingdom. How the animals lost their sensors 2012-11-25T17:45:00.383Z After dissociating, the G protein can interact with a variety of other proteins, including proteins called kinases which attach and detach phosphate groups and control cell signaling. G Protein-Coupled Receptors (GPCRs) win 2012 Nobel Prize in Chemistry 2012-10-10T13:45:00.463Z In luminal/ER cancers, the high frequency of PIK3CA mutations suggests that inhibitors of this activated kinase or its signalling pathway may be beneficial. Comprehensive molecular portraits of human breast tumours 2012-10-03T18:22:40.017Z We further studied how transcription factors in different levels are regulated by kinases. Architecture of the human regulatory network derived from ENCODE data 2012-09-05T17:22:04.360Z Our analysis for significantly mutated cancer genes identified 23 candidates, including the cell cycle checkpoint kinase ATM. Recurrent R-spondin fusions in colon cancer 2012-08-29T17:52:03.740Z Novel classes of drugs such as mitotic checkpoint kinase or kinesin inhibitors, which target the maintenance of tetraploidy through successive cell divisions, may therefore represent a rational therapeutic strategy in these cases. Dissecting the genomic complexity underlying medulloblastoma 2012-08-01T17:52:34.853Z “We were very surprised to find that the top overexpressed kinases have not been studied in breast cancer at all,” says Radovich — a result suggesting new drug targets. Molecular oncology: The positive in the negative 2012-05-30T17:51:02.510Z Big screens for genes for behaviors usually come up with genes for kinases, neurotransmitter receptors, neuronal development factors and other generalized components of the nervous system. Clocks, metabolism, evolution - toward an integrative chronobiology 2012-05-30T12:45:00.197Z He is a veteran of experiments on six space-shuttle missions, and tried to crystallize one particular kinase, a signalling protein, aboard the ISS. Space-station rendezvous set to spur research push 2012-04-25T17:20:25.877Z He is a veteran of experiments on six space-shuttle missions, and tried to crystallize one particular kinase, a signaling protein, aboard the ISS. SpaceX Docking at Space Station Set to Free Data Stuck in Orbit 2012-04-25T14:45:15.690Z At first, no drug company thought it was possible, assuming that drugs would also block normal kinases and prevent all the cells from dividing. Cancer: Solving an age-old problem 2012-02-29T18:21:13.613Z The hope is to eventually incorporate the phosphoproteome: the set of proteins that is modified by addition of a phosphate group by protein kinases, thereby altering the proteins' activity in intracellular signalling pathways. Molecular oncology: The positive in the negative 2012-05-30T17:51:02.510Z In addition to secondary mutations and gene amplification, we also identified aberrant activation of other kinases including marked amplification of KIT and increased autophosphorylation of epidermal growth factor receptor in drug-resistant tumors from patients. [Research Articles] Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers 2012-02-08T20:55:12.513Z In Science Translational Medicine, two recent studies provide new insight into mechanisms of resistance to ALK tyrosine kinase inhibitors and possible strategies to overcome this resistance. [Perspectives] Escaping ALK Inhibition: Mechanisms of and Strategies to Overcome Resistance 2012-02-08T20:55:04.923Z Anderson Cancer center showing that some forms of inflammatory breast cancer, a particularly deadly kind, are caused by mutations that boost levels of anaplastic lymphoma kinase, or ALK. The Cure For Komen: Real Research, Real Drugs 2012-02-08T20:06:16Z Why not create a drug to stop this rogue kinase? Cancer: Solving an age-old problem 2012-02-29T18:21:13.613Z Masitinib targets mast cells, which help govern immunity, and kinases, a type of enzyme that plays a role in the growth of cancerous cells. AB Soars 46% as Cancer Drug Beats Pfizer’s Sutent: Paris Mover 2012-02-02T16:38:23Z The biotech company also expects results late this year from four Phase II cancer trials of its experimental PX-866 -- a drug from a class known as PI-3 kinase inhibitors. Oncothyreon awaits key lung cancer vaccine data 2012-01-11T21:05:19Z The aberrant activation of these kinases, he says, is “a unifying event in the pathogenesis of the disease”. Genetics: Profiling a shape-shifter 2011-12-14T18:21:12.203Z Both of these older drugs, respectively known generically as dasatinib and nilotinib, are members of a class called tyrosine kinase inhibitors. Ariad leukemia drug helps 47 percent of patient: study 2011-12-12T00:31:59Z Its scientific founders, all members of the prestigious National Academies of Science, include experts who helped discover the PI3 kinase mechanism that is a key drug target for companies like and . Why You Should Care That A Tiny Company Is Entering The Ultra-Rare Disease Market 2011-11-17T13:34:47Z JAK inhibitors block the action of proteins called Janus-associated kinases which are involved in signaling in cells. Prescriptions Blog: F.D.A. Approves Drug for Bone Marrow Disease 2011-11-16T23:24:35Z George Sledge, an oncologist at Indiana University in Indianapolis, offers the example of a class of drug that inhibits enzymes called kinases. Translational research: 4 ways to fix the clinical trial 2011-09-28T17:21:04.080Z Xalkori blocks the growth of tumours caused by a mutant form of the gene which encodes a signalling molecule known as anaplastic lymphoma kinase. Oncology and genetics: Grabbing cancer by the short and curlies 2011-09-21T18:32:51Z Ariad's drug is designed to target an abnormal tyrosine kinase that is closely associated with CML and Philadelphia chromosome positive acute lymphoblastic leukemia. Ariad leukemia drug helps 47 percent of patient: study 2011-12-12T00:31:59Z But by the 1990s, at Sugen, he was doing something very different, developing cancer-fighting pills that work by blocking enzymes called tyrosine kinases that cells use to communicate with one another. Serial Lifesaver 2011-09-06T20:05:05Z The FDA said it also approved a genetic test to screen for the mutation, known as an abnormal anaplastic lymphoma kinase gene. FDA approves gene-targeting lung cancer drug 2011-08-26T22:40:09Z Imagine a trial that targets two kinases, one of which is mutated in 25% of patients, and the other of which is mutated in 8%. Translational research: 4 ways to fix the clinical trial 2011-09-28T17:21:04.080Z A drug that blocks a component of this cascade called Rho kinase reduced the damage to axons. How Blasts Injure the Brain 2011-07-22T22:00:00Z Exportin 1 is implicated in the nuclear export of proteins and mRNAs in yeast, including members of the MAP kinase pathway. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia 2011-07-06T17:21:01.303Z He created Plexxikon in December 2000 to find a way to invent new pills, including kinase blockers, which were more targeted, with fewer side effects. Serial Lifesaver 2011-09-06T20:05:05Z A positive answer would confirm a structure consistent with the specificity of DNA kinase and provide a labeled species useful for further downstream analysis. [Technical Comment] Comment on ?A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus? 2011-06-02T18:25:14.937Z Probably driven by natural selection, the metazoan ancestor used the increasing numbers of tyrosine kinases to enhance the evolutionary capability toward the stage of multicellularity. [Technical Comment] Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:16.067Z The authors then tested how strongly nelfinavir binds to the 12 protein kinases predicted by their model as being the best fit. Computer Algorithm May Speed Drug Discovery 2011-04-29T19:44:56Z The video shows p27 binding to a kinase enzyme to regulate cell division. The Orderly Chaos of Proteins [Video] 2011-04-18T11:45:05.227Z Its first drug, which was not a kinase blocker, was to fight diabetes. Serial Lifesaver 2011-09-06T20:05:05Z "I was cautious at first, but this study is impressive because they've specifically altered levels of the kinase." Enzyme Can Strengthen Old Memories 2011-03-04T00:45:00.450Z Zhuo and colleagues found raised levels of the enzyme "protein kinase M zeta" in a region of the brain called the anterior cingulate cortex of the injured mice. Experts find brain enzyme that makes pain last 2010-12-02T19:25:00Z In all, the authors identified 92 binding partners, 85 of which belonged to a family of proteins called protein kinases. Computer Algorithm May Speed Drug Discovery 2011-04-29T19:44:56Z Many other companies and scientists are trying to develop drugs that inhibit enzymes — for example, pyruvate kinase M2, involved in tumor metabolism. Fuel Lines of Tumors Are New Target 2010-11-30T08:45:00Z Mastitinib is a tyrosine kinase inhibitor which stops the growth of cancer. UPDATE 1-AB Science wins skin cancer study shortcut 2010-10-05T15:45:00Z Protein phosphatases are the opposite side of the coin that catalytic enzymes known as protein kinases occupy. Plants Give Up Some Deep Secrets of Drought Resistance 2010-08-24T14:35:00Z Light, and the cycle of day and night, are important for resetting the clock, and fine adjustments are controlled by the activity of several enzymes, including one called casein kinase 1 or CK-1. Body clock mouse study suggests new drug potential 2010-08-23T17:51:00Z Improper kinase activity strongly dampens the signals that tell the tumor cell to divide. Computer Algorithm May Speed Drug Discovery 2011-04-29T19:44:56Z Their blood contained lower levels of creatine kinase, a biochemical marker of trauma in muscle tissue. Phys Ed: What Exercise Science Doesn't Know About Women? 2010-06-30T04:01:00Z All three drugs belong to a class called tyrosine kinase inhibitors that target a family of proteins highly active in many types of cancer cells. Sprycel tops Gleevec in newly diagnosed CML: study 2010-06-05T14:39:00Z In many important biological processes, such as cancer, it is the protein kinases that are the dominant actors. Plants Give Up Some Deep Secrets of Drought Resistance 2010-08-24T14:35:00Z "But in glioblastoma and other cancers, p16 is frequently deleted, and these two kinases are uncontrollably activated, which drives the cell to divide and form cancer." Pfizer, Onyx drug offers hope against brain cancer 2010-03-30T17:00:00Z This weak action against many kinases effectively applies the brakes on uncontrolled cell division. Computer Algorithm May Speed Drug Discovery 2011-04-29T19:44:56Z R788 is the furthest developed in a new class of drugs called oral spleen tyrosine kinase inhibitors being evaluated for rheumatoid arthritis. 2010-02-16T16:54:00Z |
| 随便看 |
英语例句辞典收录了117811条英语例句在线翻译词条，基本涵盖了全部常用单词及词组的例句翻译及用法，是英语学习的有利工具。