| 单词 | inhibition |
| 例句 | She had obviously never been in the company of a black who had no inhibitions around whites. Long Walk to Freedom 1994-01-01T00:00:00Z But looking at Dimple’s open face, hearing her earnest questions, his usual inhibitions turned to puffs of cloud, insubstantial, floating away as he tried to grasp them. When Dimple Met Rishi 2017-05-30T00:00:00Z The students have shared their life experiences freely, without inhibition. The Freedom Writers Diary 1999-10-12T00:00:00Z Freed of normal constraints, some of the young let go of their inhibitions and, under cover of darkness, caressed one another, without any thought of others, alone in the world. Night 1955-01-01T00:00:00Z And Mr Harry Smith himself seemed to lose all inhibitions, for now he leaned forward and continued: 'That's what we fought Hitler for, after all. The Remains of the Day 1989-05-01T00:00:00Z Thus, farmers selected from among individual plants on the basis not only of perceptible qualities like size and taste, but also of invisible features like seed dispersal mechanisms, germination inhibition, and reproductive biology. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z This time, I let go of the inhibitions, the safeguards I’ve taught myself to always hold up. Beasts of Prey 2021-09-28T00:00:00Z Second, the dominant position acquired by Aristotelian natural philosophy within the medieval universities resulted in a double inhibition on experimentation. The Invention of Science 2015-09-17T00:00:00Z He had no inhibitions, and whatever ones he discovered I had he’d pry away from me like little treasures. The Joy Luck Club 1989-01-01T00:00:00Z She moved in front of me with no shyness or inhibition. Flowers for Algernon 1959-05-01T00:00:00Z In retrospect she saw that her sudden lack of inhibition had intoxicated her more than any of the men had. The Namesake 2003-09-01T00:00:00Z Relationships between young men and women of his unpropertied class were fraught with restriction and inhibition. The Story of Music 2012-12-25T00:00:00Z Barley has the further advantage that its genetics and morphology permit it to evolve quickly the useful changes in seed dispersal and germination inhibition that we discussed in the preceding chapter. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z He had disguised the event as a football rally, strictly for students, without the inhibition of the teachers being present. The Chocolate War 1974-01-01T00:00:00Z I didn't like it, for when he was upstairs they had absolutely no inhibitions. Invisible Man 1952-01-01T00:00:00Z Like the changes in seed dispersal, these changes in germination inhibition characterize wheat, barley, peas, and many other crops compared with their wild ancestors. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z He was a nut, known for his lack of inhibitions, his complete disregard of the rules. The Chocolate War 1974-01-01T00:00:00Z Alone, with appalling abruptness, she could shed her inhibitions. Do Androids Dream of Electric Sheep? 1968-01-02T00:00:00Z He’s always been a cheerful, good-natured kid, with very few inhibitions, which sometimes does not lead to the best classroom behavior. Tears of a Tiger 1994-01-01T00:00:00Z Can you talk about what I might call your lack of inhibition? Fran Drescher reveals the role she turned down out of principle: "Who am I if not my word?" 2019-05-02T04:00:00Z The movie director James Ivory is closely associated with paeans to inhibition like “Howards End” and “The Remains of the Day.” Times Critics’ Top Books of 2021 2021-12-15T05:00:00Z Her most persistent suitor is a surgeon pushing aggressively against the limits and inhibitions of medical science. The most delightful heroine since Elizabeth Bennet 2017-06-05T04:00:00Z There are no such inhibitions in the wealthier suburbs of Tel Aviv. ‘Real Housewives’ in Greece, Israel and Canada 2013-06-06T12:00:01Z To my delight, he also cast off some of the inhibitions that are a feature of so many men of his generation. How Alzheimer’s took my brilliant dad, Lord Goodhart, in increments 2017-05-20T04:00:00Z Can still recall the unalloyed relief after 9/11 on a reopened Broadway, as theatergoers shed their inhibitions and bopped in the aisles to “Mamma Mia’s” “Dancing Queen.” Perspective | Play It Again | These songs from musicals changed my life. Now they can sustain me. 2020-05-06T04:00:00Z The movie is set in a Southern town where inhibitions run low. ‘Giants Being Lonely’ Review: Indie Filmmaking Being Twee 2021-04-06T04:00:00Z You asked why I drank when I know what happens to girls who drink, whose inhibitions are lowered. A letter to… my mother who blamed me when I was raped 2018-11-24T05:00:00Z Others are circumspect, our social skills atrophied and our inhibitions increased in response to a lethal disease. ‘Romeo and Juliet’ Meets the Hot Vax Summer 2021-04-30T04:00:00Z Just maybe, when dancers bump against the glass wall of their own physical and emotional inhibitions, there will be a breakthrough. Spectrum's Donald Byrd asks everything of his dancers, and his audience 2012-11-28T23:59:27Z These peasant executioners were often given wine to loosen their inhibitions. | 'Enemies of the People': Cambodian Journalist Revisits Khmer Rouge 2010-07-29T22:13:00Z But then again, Gilbert said, maybe that explains her inhibition, her restraint, or whatever you want to call it — she’s always keeping a supply of herself on hand for future use. Sara Gilbert Balances Her Lives on ‘The Conners’ and ‘The Talk’ 2019-01-14T05:00:00Z When we were tiny, we all danced without any inhibitions – it's only as we grow up that dancing gets relegated to something we do when we're drunk, or at a wedding. Kate Prince, choreographer – portrait of the artist 2012-10-09T17:15:01Z He described it as “a kind of naïveté, almost like a childlike relationship with the world around you — that freedom from inhibition that sparks creativity and inspiration and allows random beauty to occur.” In ‘Dispatches From Elsewhere,’ Art Imitates Art Imitating Life 2020-02-27T05:00:00Z A gallery displaying 45 of her small black-and-white prints reveals a man with few inhibitions and a remarkable talent for enjoying life. Art Review: ‘Ferdinand Hodler: View to Infinity,’ at Neue Galerie 2012-09-20T21:50:42Z "You need a lack of inhibition, a lack of sobriety, and a lack of dignity," says Crane. The Air Guitar 2010-07-22T14:05:00Z “Any hesitation or inhibition and you can fall flat. It doesn’t flow.” Music Center dance lineup for 2015-16: Second City, hip-hop, Ratmansky 2015-05-06T04:00:00Z He also shed the toupee he had worn in the Bond movies – he had started losing his hair at the age of 21 – and all the inhibitions to which sex objects and superstars are prey. Sir Sean Connery obituary 2020-10-31T04:00:00Z Mr. Gardiner was meticulous, sure, yet he also left room for captivating inhibition. This Is How to Do a Beethoven Symphony Cycle 2020-02-26T05:00:00Z In their effort to raise children without inhibitions, my parents and their peers eschewed the teachings of Benjamin Spock and went for a more anarchic, Fellini-esque parenting approach. Boomer parents destroyed us: I needed rules and boundaries, not parents who want to be friends 2015-04-01T04:00:00Z While Jones still plays on the Casio keyboard from his teenage years, he learned to shed those inhibitions. Caleb Landry Jones is known for playing weird, kind of creepy characters. His new album is also weird and kind of creepy. 2021-09-22T04:00:00Z To party, you gather all your people together, fill their cups, fill their plates, fill their bellies and let a voodoo magic happen – that spell which falls when inhibitions fade and voices rise. Jacob Kenedy’s recipe for a Louisiana-style turkey gumbo ya ya | Christmas leftover recipes 2017-12-25T05:00:00Z “When I first witnessed the entire city on their rooftops, staring up at the sky, their kites dueling ferociously, dancing without inhibition, I knew I had to make this film in Ahmedabad,” Mr. Bhargava said. Prashant Bhargava, Filmmaker of ‘Patang (The Kite),’ Dies at 42 2015-05-18T04:00:00Z His mother has recently died, something that perhaps frees him from various inhibitions. This Week in Fiction: Tim Parks 2014-11-30T05:00:00Z The opening-up and opening-out of the body that is basic to ballet’s classicism doesn’t really occur here; women dance on point but with arms folding in to express inhibitions. Dance Review: ‘Swan Lake’ by Australian Ballet at Koch Theater 2012-06-17T22:05:37Z Robyn’s individuality draws in fans inspired by her lack of inhibition. How Robyn, Pop’s Glittery Rebel, Danced Her Way Back From Darkness 2018-09-21T04:00:00Z One of the things I admire about French cinema is the unflinching bourgeois realism; or is it perhaps the lack of inhibition about where they find inspiration? French films glow with confidence and culture. Ours should do the same 2010-08-07T23:05:00Z Experts also reportedly noted that people tend to get intoxicated in bars, and getting drunk lowers inhibitions. New study explains why bars are perfect for spreading coronavirus 2020-07-02T04:00:00Z Dating from before Stonewall, the site was a place where stigma and inhibitions were left at the coat check. Reminiscences of a ?Gay Utopia? 2011-11-19T00:08:14Z Some of these plants remain upright and stoic during this transition, others lose their inhibitions by gyrating and leaning as they exchange their greenery for something a little more gaudy. During the ‘fifth season,’ plants take on a strange beauty in decline 2017-10-17T04:00:00Z After puberty, he found himself paralyzed by body insecurities, sexual inhibitions, hypochondria and the expectations of upper-middle-class society. His Own Best Character 2011-05-18T20:55:46Z Yet this sense of inhibition may be the movie’s signal virtue. Tarzan Cannot Be Rebooted 2016-06-30T04:00:00Z The researchers think this is because the active region of the brain is associated with cognitive inhibition. Why doesn’t everyone believe in God?: The skeptical brain may hold the answer 2015-07-05T04:00:00Z The production does feature some entertaining, if perhaps not plausible, set-piece sequences, such as an episode in which Lionel, shedding his inhibitions, waxes passionate on the subject of Pollock’s creative process. A potential Jackson Pollock painting sparks an exaggerated class war 2016-05-17T04:00:00Z But as the effects of this change move up the food chain, Grain No. 1 not only unlocks a “molecular inhibition” with devastating digestive consequences, it unlocks a pandemic of sexual inhibition as well. From the Schlump With the Shiv, Two Plays Turned Podcasts 2021-07-07T04:00:00Z Her real bequest to Brockes was the psychological freedom to be able to confront the past without inhibition, and to take straight aim at it. She Left Me the Gun: My Mother's Life Before Me by Emma Brockes – review 2013-03-22T09:01:01Z But there are so many taboos and inhibitions, so many dos and don’ts in our society, that are pervasive as well. Love in India 2015-02-05T05:00:00Z They are guides and sympathetic listeners helping her through her angst and inhibition. ‘Touch Me Not’ Review: Our Bodies Examined 2019-01-09T05:00:00Z Even at a moment of global fear of contagion, a spirit of generosity and communal love of Burgundy overcame inhibitions. A Vintage Bash for All Things Burgundy 2020-03-10T04:00:00Z Her delivery–mostly rapped, occasionally sung–is rapidfire enough to leave most rappers breathless; her message is self-realization without apologies, limits or inhibitions. ArtsBeat: Lollapalooza Chile: Tough Women Rappers, Jane's Addiction and Polite Dancers 2011-04-04T15:22:29Z Knowing there's more of everything is always comforting, and if you've been shy about turning on one of these shows, release those inhibitions and turn it on. Are "Julia" and "Minx" the same show? Basically, yes. That's wonderful 2022-04-16T04:00:00Z He also cast off some of his inhibitions. How Alzheimer’s took my brilliant dad, Lord Goodhart, in increments 2017-05-20T04:00:00Z That rapid ingestion of alcohol is going to cause a rapid spike in blood alcohol levels, as well as an associated rapid decrease in inhibitions, sense of propriety, judgment, and motor skills. “Tequila crazy” and “martini maudlin”: Do different kinds of alcohol give us a different buzz? 2016-01-05T05:00:00Z As translated by the director and screenwriter Billy Ray, this is instead a slo-mo horror story, in which the worst lack all inhibition while the best are full of fatuous integrity. Review: ‘The Comey Rule’ and What a Fool Believes 2020-09-24T04:00:00Z Through economic necessity, like so many working artists, Dutton and Swindells have had to get involved in the academic world, with all its theoretical inhibitions and obligatory research outcomes. This week's new exhibitions 2011-02-26T00:07:56Z I’ve discovered that working under a name other than the one in my passport—while an undeniable hassle in airports, hotels, and banks—is a marvelous way to dodge my inhibitions. What’s in a Pen Name? 2014-05-23T04:00:00Z Or only when stripped of inhibition, either by alcohol or online anonymity. Online agitator. Leftist know-it-all. Is the Bernie Bro back? 2019-03-12T04:00:00Z Still, once she committed to the role and left all her inhibitions at the door, embodying Ma Rainey was “fan-friggin-fantastic,” she said. First Look: Viola Davis and Chadwick Boseman in ‘Ma Rainey’s Black Bottom’ 2020-09-30T04:00:00Z No, the real reason for encouraging novelists to overcome their critical inhibitions is that their contributions help maintain the rigor and vitality of the public conversation about books. Bookends: Are Novelists Too Wary of Criticizing Other Novelists? 2013-09-03T17:19:22Z Working in drag helped Ghee develop as a theatrical performer in their subsequent gigs at Tokyo Disneyland and on cruise ships, they said, losing inhibitions and gaining agency onstage. In ‘Some Like It Hot,’ J. Harrison Ghee Brings Their Whole Self 2023-05-10T04:00:00Z His classes — part yoga, part boot camp, part mime, all acting — push students past inhibition. Juilliard’s Secret Weapon Keeps Actors on Their Toes 2020-06-19T04:00:00Z I wanted to cry then and at plenty of other times, but inhibition always won out. My life as a teen brawler 2012-09-03T14:00:00Z Breaking her routine as well, the sleight of hand clears space for her voice to burst, frankly and scathingly, through her own inhibitions as well as through the very fabric of Hong’s film. Standouts from the New York Film Festival 2016-10-11T04:00:00Z After donning a pair of blue webbed gloves for extra resistance, I checked my inhibitions at the poolside and joined 13 students — most were women — in the water. Urban Athlete: Aqua Zumba and Deepwater Running Round Out Fitness Routine 2012-08-02T19:28:37Z Preying on our inhibitions, this naughty menu item is served till 1 a.m. with its two, fluffy buttermilk pancakes topped with roasted pork, plus sides of maple syrup and clarified butter for good measure. Up late and hungry at Comic-Con? Here are 11 late-night dining picks 2015-07-07T04:00:00Z Olmi’s intimate camera captures his performers’ delicate range of inflections and glimmers of feeling as their inhibitions begin to curdle into weary bitterness. Movies 2014-06-02T04:00:00Z Where Mack is lovably sleazy, the creaky Williams is inhibition personified. ‘Living’ Review: Losing His Inhibition 2022-12-22T05:00:00Z Research indicates that people do better at creative problem-solving, as opposed to more analytical challenges such as memory questions, at their non-optimal times, when inhibition is lower. Creativity may be key to healthy aging. Here are ways to stay inspired. 2021-07-10T04:00:00Z If adults want to use substances together to loosen their inhibitions, that’s their business. Bill Cosby headlines miss the point: His admissions aren’t about “having sex,” they’re about assault 2015-07-07T04:00:00Z As these are common breakfast foods that may be consumed with a morning coffee or tea, the inhibition effect may be even stronger due to the presence of phenolic compounds in these beverages. Future diets will be short of micronutrients like iron — it’s time to consider how we feed people 2023-09-05T04:00:00Z There’s nothing to lose but stress and inhibitions. DanceAfrica, Dormeshia and Contact Improvisation (for One) 2020-05-19T04:00:00Z That sense of inhibition flies out the window when ordering in a group. Thanks for Not Sharing! My Fine Dining Isn’t Your Fork Orgy 2018-03-21T04:00:00Z Margaret always dances with such joy and abandon, but seems to abandon any semblance of technique right along with her inhibitions. "Dancing with the Stars": Florentine Henderson, reluctant maiden? 2010-10-05T12:30:00Z With a magnetic brain-stimulating device, it’s possible to temporarily zap the cells responsible for inhibition. How to overcome your inhibitions 2016-02-14T05:00:00Z But he had a dream: to liberate 1950s sex from the bedrooms of marrieds, from shame and inhibition and boredom. Can Hugh Hefner’s 26-year-old son convince his generation that Playboy is sexy? 2018-06-19T04:00:00Z In Ward’s book, the genre’s defining acts emerge in moments when inhibition fell by the wayside. Once upon a time, rock-and-roll was strange, wild and dangerous 2016-12-12T05:00:00Z Some of those interns, dressed as Dr. Schiller’s lab assistants, help set the tone with a preshow survey of the audience that signals this is not a place for inhibitions. ?Never Sleep Alone? Leads to Audience Relationships 2011-11-30T22:45:03Z Researchers found that those who played the violent video games showed less activity in areas that involved emotions, attention and inhibition of our impulses. How Playing Violent Video Games May Change the Brain 2011-12-05T18:20:09Z Young bodies are made for tossing inhibitions to the wind. Women and desire: the six ages of sex 2017-02-19T05:00:00Z Her casual conversations with Tony Blair – "babe, it's fine" – and her flashing her knickers at David Trimble are oddly endearing, showing Mo's lack of inhibition. Young arts critics competition 2010: the winning entries 2010-10-20T22:00:00Z All that ethereal theatricality dispelled the last of my shopper’s inhibitions. | ABC Carpet & Home: ABC Carpet & Home: the Name Belies the Exoticism 2010-05-04T23:40:00Z Living under your parents’ roof is tough as an adult and even harder when at least one of them displays the self-restraint and inhibitions of a toddler. My stepdad won’t stop watching porn in our house | Mariella Frostrup 2017-08-20T04:00:00Z But sakura simultaneously create an intoxicating excitement, giving permission to throw off inhibitions. Gustavo Dudamel 'very happy' with decision to stay in L.A. 2015-03-30T04:00:00Z The author practices a tender reticence, as if she were trying to respect her characters’ inhibitions. Akil Kumarasamy’s “Half Gods”: A Début Collection Explores Strife, Trauma, and “a Lifetime Loving Strangers” 2018-06-07T04:00:00Z I suggest you regard this visitor as an old friend, throw your inhibitions back into Pandora’s box and enjoy the further understanding of your partner that meeting someone with whom she has history will bring. My partner wants her ex to stay over, and it makes me worry | Dear Mariella 2021-03-07T05:00:00Z "This is Chekhov refreshed and reimagined - and acted with total lack of inhibition," . Matthew Kelly cast in The Seagull 2012-09-17T15:33:45Z Though as a performer Black is famous for his utter lack of inhibition, offscreen he spends a lot of time in his own head and can sometimes over-think things. Jack Black is game for anything -- except vanity 2015-05-01T04:00:00Z The cartoonists and graphic novelists who live and work here are a motley, back-of-the-classroom crowd, happily throwing spitballs at our conventions, our inhibitions, our unabashed pleasantness. Alt comics artists take us to our rough edges 2014-03-12T22:48:22Z One example of where cognitive inhibition is useful is in overcoming prejudice. Why doesn’t everyone believe in God?: The skeptical brain may hold the answer 2015-07-05T04:00:00Z It’s easy to wax poetic about the impression created by this labyrinthine but changeable chamber music; let’s lose our inhibitions and say it suggests the pointillist shimmer of waning light over a tidal surface. New Music: Dumpstaphunk, Five Finger Death Punch and Ben Monder 2013-07-29T22:08:11Z Now compare that felt inhibition to another problem: say, shooting someone who has surrendered, someone with their hands up. ‘The Walking Dead’ Season 8, Episode 3: Cut to Black 2017-11-05T04:00:00Z Claire’s brush with death frees her of any erotic inhibitions but never represses her ample decency and kindness. ‘White as Snow’ Review: The Fairest of Them All 2021-08-12T04:00:00Z It went against every instinct I had when the CIA first asked me to tell this story, but eventually I lost my inhibition. Former spy talks "Argo," and Iran rescue mission 2012-10-12T15:03:31Z Before entering the space, the participants leave their shoes at the door, along with their inhibitions and self-consciousness. A Philadelphia Theater Heading, and Sweating, in a New Direction 2018-01-03T05:00:00Z “Having had a drink — people don’t have any inhibitions. You go out with work friends and start talking about things you wouldn’t normally talk about with them — all your worldly troubles.” Holiday office parties: So very merry. And awkward. 2014-12-11T05:00:00Z In this composer’s rarefied world, impulse overrules inhibition; cause and effect are for naïfs; one plus two equals an imaginary number. Why a fashionable young audience flocked to hear an obscure Greek composer's soundscape 2017-04-25T04:00:00Z The revelation is that by evoking this ceremonial, near mystic, aspect of Spanish life, Bieito also creates a setting that heightens a culture in which nerves are always on edge and inhibitions inevitably reduced. A 'Carmen' in San Francisco breaks down barriers 2016-05-30T04:00:00Z Ms. McDonald’s appearance, alas, was a one-night guest shot in an otherwise mild-mannered show in which Mr. Swenson, who confessed to being very nervous, struggled to transcend inhibitions instilled by his Mormon upbringing. Review: Will Swenson Brings His Broadway Voice to 54 Below 2015-09-17T04:00:00Z The Look: Gatsby’s Girl — the hemlines are lower, but so are the inhibitions. | Jacquetta Wheeler 2010-12-17T20:15:58Z Alan Bates and Oliver Reed’s nude wrestling scene in Ken Russell’s romantic classic still impresses with its total lack of inhibition. 12 great male nude film scenes, beyond the cheap laughs 2016-05-13T04:00:00Z I have a bit of an inhibition about reading painful and disturbing books, which I am trying to work through. Alison Bechdel: By the Book 2012-07-26T14:36:01Z The audience lose their inhibitions as the show goes on. Jimmy Carr: Laughing on the other side of his face 2012-06-23T23:06:26Z He felt no inhibition, no sense of holding back from this man. Anonymous strikes back 2012-06-03T13:00:00Z In Williams’s hands, a similar clash of sensibilities becomes a keening paean to all the loves lost to fear, contempt and inhibition. | 'One Arm': Hustler on the Streets, Missing Both a Limb and a Capacity to Feel 2011-06-10T02:01:04Z The collision of her good-faith lack of inhibition with institutionalized misogyny makes this Canadian’s biography a very disquieting American story. ‘Pamela, a Love Story’ Review: A Frank Look Back 2023-01-31T05:00:00Z There is no inhibition, and no awaiting instruction. The world's best orchestra 2011-02-27T00:04:15Z What strikes me even more is how she pins down a subject Conor McPherson was to develop in The Weir: the emotional inhibition of the small-town Irish male. Wife to James Whelan ? review 2011-04-07T19:04:01Z “With a lack of inhibition and a lack of social decorum comes a sense of wanting to be as extra as humanly possible for the sake of catching up on lost time,” Mr. Stampa-Brown said. New York’s Brief Hot Restaurant Summer: Bread Binges and Dance Parties 2021-08-30T04:00:00Z That said, she reckoned Meghan had “slight inhibitions” about the reveal of the child. Meghan has given birth to a raft of royal experts 2019-05-09T04:00:00Z Through film documentary, significant sculptural objects and innumerable drawings executed by her untrained collaborators, the artist exposes and helps to tentatively dissolve the social inhibitions that tend to plague our post-industrial environments. This week's new exhibitions 2011-02-26T00:07:56Z Children with no bedtimes bounced alongside adults with no inhibitions. On a Baltic Sea cruise, board in Sweden and wake up in Latvia — then do it in reverse 2019-10-03T04:00:00Z Mr. Parker neither understands nor respects Marlowe's inhibitions; he fritters them away, unconsciously questing for some contemporary ideal of gruff likability. ArtsBeat: Philip Marlowe Set to Return in Novel by John Banville 2012-08-07T19:08:10Z If they have the slightest inhibition in their heads, it won't work.' Ulrich Seidl: 'Those who say I despise people do not understand me' 2013-06-13T13:00:02Z For learning to be efficient, your brain needs a delicate balance of excitation and inhibition—too much in either direction and the circuits do not work optimally.” Alcohol and the teen brain: There’s evidence binge drinking is dangerous for the adolescent brain — but guess what substance gets the bad rap 2015-11-30T05:00:00Z Gould says he saw elements of himself in her, that same inhibition from childhood: “She presents herself the way I feel about myself.” ‘Of course I smoked marijuana!’ Elliott Gould on stardom, Streisand and Elvis Presley 2020-04-20T04:00:00Z When online daters discover this cornucopia of flesh, they cast aside inhibition and commit to serial novelty. What does OKCupid want? 2013-02-16T17:00:00Z It’s a decidedly public experience that probably isn’t ideal for platonic travel partners or for anyone with a trace of inhibition. Check In, Check Out: Hotel Review: Ohla Hotel, Barcelona 2012-02-24T15:50:46Z Yet as she progressed through it, she increasingly let go of her inhibitions and began to discover the dangerous sparkle of Odile, and you could sense that Ms. Fairchild was coming around to “Swan Lake.” Megan Fairchild, the Swan With the Screwball Spark 2017-09-22T04:00:00Z The Task process seemed to lower inhibitions and promote a sense of freedom, even though the tasks were, in effect, class work. Oliver Herring at a Task party at Madison Square Park 2014-09-07T04:00:00Z Models in the traditional academies were almost always men, and by the 20th century the artists who sketched them were losing some of their inhibitions about the curves and volumes they depicted. ‘Rear View’ Is Rather Forward Thinking 2023-04-20T04:00:00Z But during a jibing drill — directing the stern into and through the wind — I let go of my inhibitions. In the British Virgin Islands I learned to sail — for my father, while there was still time 2017-09-06T04:00:00Z In these stories, people’s lives are shaped by domestic confinement and social inhibition. Sense and social distancing: 'Lockdown has given me a newfound affinity with Jane Austen's heroines' | Josephine Tovey 2020-04-29T04:00:00Z In more than one song, she sings about her fears and inhibitions, even as her voice leaves no question that she will conquer them. On Alice Merton’s Debut ‘Mint,’ Hooks Conquer Fears 2019-01-23T05:00:00Z We might have overcome our inhibitions about following characters into the bedroom, but we want a birth over with in a neat-and-tidy jump cut. Why doesn't fiction deliver birth scenes? 2012-08-05T18:00:01Z Alcoholic drinks as you walk into the party typically lowers your inhibition and encourage overeating. Fitness expert Tracey Mallett shares tips on exercising and keeping your New Year's resolutions 2019-12-27T05:00:00Z To my surprise, I had few inhibitions and we joyfully embarked on a pleasurable physical relationship. My life in sex: ‘At 70, I’m having great sex’ 2019-09-27T04:00:00Z “There’s an exuberance or just kind of a lack of inhibition when they’re performing at home,” Mr. Malhotra said of the Manganiyars, whose music is a mix of traditional melodies and arresting vocals. Preserving Manganiyars and Their Indian Folk Music Tradition 2012-08-22T21:35:34Z When they finally gather onstage, they dance a bit, free form, shaking out the kinks and inhibitions the way one often does at a party or discothèque. 'Seagull' and 'Sense and Sensibility,' From Bedlam Company 2014-11-26T05:00:00Z Cromwell, at 78, might be assumed to have shed any youthful inhibitions about speaking his mind. James Cromwell: 'In jail, everyone recognises my face' 2018-02-27T05:00:00Z The greatest inhibition, to use Senator Sanders's word, is mental rather than physical. George Orwell back in fashion as Prism stokes paranoia about Big Brother 2013-06-11T17:08:01Z Usually, this is at a level which is easily suppressed by your inhibitions. How to overcome your inhibitions 2016-02-14T05:00:00Z An unparalleled lack of inhibition has always defined Blair’s best-known work. Selma Blair Wants You to See Her Living With Multiple Sclerosis 2021-10-13T04:00:00Z All moral concerns and social inhibitions are suspended in the narcissism of sleep. Review | ‘The Day the Sun Died’ is a social comedy that bleeds like a zombie apocalypse 2018-12-21T05:00:00Z Griffith dies and is reborn as Femto, a member of the God Hand, who is undeterred by moral inhibitions. Exclusive: Inside accused Annapolis shooter’s alt-right theology of mass murder 2018-07-22T04:00:00Z After weeks of admiring him from afar, she abandoned her inhibitions and, without words, invited him to dance. On Love: Janae Johnson and Rob Gallun 2015-03-12T04:00:00Z “It’s always amusing but heartening to hear liberals talk about the separation of powers, the independent judiciary and other inhibitions on executive action,” he said. ‘Charge the Cockpit or You Die’: Behind an Incendiary Case for Trump 2017-02-20T05:00:00Z After festival organizers agreed to move the event from busy weekend trading hours to a quiet Monday morning, Woolworths shed its inhibitions to allow the event to go ahead on July 9. Australian supermarket giant says 'yes' to mass nude photograph 2018-06-16T04:00:00Z The work involved breaking down inhibitions; both hers and theirs. Gillian Wearing: A nose for the truth 2011-08-29T20:30:01Z Consuming alcohol, it seems, tends to elevate desire and reduce inhibitions more than alter our actual perception of another person’s attractiveness. The Trick to Finding Your Soul Mate? Change Your Expectations 2014-08-28T04:00:00Z Art is the only way to open horizons in front of your eyes, instead of being bound by inhibitions and prohibitions. Is the Arab world ready for a reading revolution? 2010-04-16T10:19:00Z All in all, inhibition outweighed risk — a perfect recreation of a time when we were all inside, wondering if we’d ever be set free. Dua Lipa Brings Her Lockdown Anthems to the Arena 2022-03-02T05:00:00Z If most people feel that inhibition, especially while arguing that it is logical or necessary to defend self, family, or innocents with lethal force, what conclusion do you draw? ‘The Walking Dead’ Season 8, Episode 3: Cut to Black 2017-11-05T04:00:00Z "If they have the slightest inhibition or censorship in their heads, it won't work." Ulrich Seidl: 'Those who say I despise people do not understand me' 2013-06-13T13:00:02Z “Unfortunately, he was already drinking a lot at that time. But he inspired me and told me to forget my inhibitions and let myself go.” Ken Adam, who made Bond villain lairs and ‘Dr. Strangelove’ War Room, dies at 95 2016-03-11T05:00:00Z But first, he said, he had to deal with the errors and the inhibitions that had been keeping him quiet. Jimmy Fallon Is Sorry. But What Does That Mean? 2020-06-11T04:00:00Z First, “it’s a developmentally messy period. A lot of brain growth is happening,” which affects kids’ impulsivity and inhibition. Perspective | All kids lie: How to handle it, and when you should worry 2021-07-26T04:00:00Z “She has no inhibitions about talking to people,” said Zad Rogers, one of her stepsons, whose company, Atomized Studios, produced the podcast with iHeartRadio. Getting Intimate With the Celebrity Regulars of River Cafe 2021-09-20T04:00:00Z She taught me to release a lot of my inhibitions, just through our physical communication.” Natalia Osipova?s Forceful Rise in Ballet 2010-06-17T22:21:00Z Vasan's halting, mousy demeanor complements the rest of the band's swagger, and watching her release her inhibitions through her guitar strings is a show all its own. "We Are Lady Parts," a fierce new comedy about a Muslim punk band, rocks our world 2021-06-03T04:00:00Z What Ben can best do for Jules is to help her lose her inhibition about exercising power, about running her company like its visionary founder and not seeking permission to do so. “The Intern” Is a Very Strange Workplace Fantasy 2015-09-25T04:00:00Z Mr Parker neither understands nor respects Marlowe's inhibitions; he fritters them away, unconsciously questing for some contemporary ideal of gruff likability. John Banville to revive Philip Marlowe in new novel 2012-08-09T09:05:12Z A place where the debauchery never stops and inhibitions are checked at the door. With steamboats and beignets, it’s no surprise New Orleans is a great destination for families 2016-05-19T04:00:00Z His debt to the schoolchildren to whom he once taught music; their lack of fear and inhibition were his inspiration. Max: A Musical Portrait of Peter Maxwell Davies - review 2011-07-16T05:00:01Z Somehow in the safety of being unknown, I am able to let my inhibitions go, to dress in costumes and act out dominatrix or total submission fantasies. My awkward sober sex life 2012-10-28T16:01:00Z Casting off a lifetime of inhibitions, Cathy flirts with her doctor, smokes a cigarette, digs a swimming pool in her yard and, in restaurants, orders only drinks and dessert. Television Review: Laura Linney in Showtime?s Cancer Comedy 2010-08-15T22:05:00Z His time in the service helped tear down some of the inhibitions he faced when pursuing an acting career, including relocating to New York. Adam Driver credits the military for the courage to act 2019-05-22T04:00:00Z I think one of the things that happens on the road is that you leave behind a lot of your own inhibitions, your own baggage. A Conversation Between Philip Caputo and William Least Heat-Moon 2013-07-11T18:37:57Z I heard more about the things that made him through the loss of inhibition that made him both irritable and so affectionate. Trauma and triumph: my father, his dementia and surviving segregation 2020-06-25T04:00:00Z This time it was apparently different, having to do with Mapplethorpe’s lack of inhibitions and his lover’s sexual prudery. Book review: ‘Wagstaff: Before and After Mapplethorpe, a Biography’ by Philip Gefter 2014-12-31T05:00:00Z Their solution: an experiment in carefully controlled day-drinking, which they believe will loosen up their inhibitions and make their lives exciting again. The Best Movies and Shows on Hulu Right Now 2020-09-11T04:00:00Z Both films are colorful and kitschy, about conservative characters who leave or enter New York City to let go of their inhibitions and the vanilla lives into which they were born. Jonathan Demme: The mentor, the maestro, the model 2017-04-28T04:00:00Z These social inhibitions are partly an expression of my personality, but also how I see my role as a director. Why ‘Dr. Brain’ Is More Subdued Than Sensational 2021-12-10T05:00:00Z Ms. Mason, blindfolded and naked, seems to lose her inhibitions when the humiliation of being observed is removed. Dance Review: Gesel Mason?s ?Women, Sex & Desire? - Review 2011-11-12T00:44:19Z Allen presents his Sid as the one sane man who, despite—or rather, because of—his neurotic inhibitions and practical artistic ambitions and ideals, remains invulnerable to such flights of grandiose and vapid thinking. Woody Allen’s Secondhand Sixties Radicalism 2016-09-30T04:00:00Z She urges viewers to set their inhibitions aside and look at the person in front of them. Newport Beach Film Festival: 'A Brave Heart' shows Lizzie Velasquez's fight 2015-04-27T04:00:00Z All my limitations and inhibitions seemed to drop away – here was the creative and emotional satisfaction I craved. I quit my boring job for university at 30. The expense was daunting, but my self-worth soared 2020-02-24T05:00:00Z After all, the easiest way to rid yourself of any inhibitions over revealing your personal life is to disguise it as somebody else's. Be Awesome: Modern Life for Modern Ladies by Hadley Freeman – review 2013-05-24T13:01:01Z But the notion that the pandemic is fading away has lowered inhibitions and excited expectations. ‘Hot Vax Summer’ is coming. Can it possibly live up to the hype? 2021-05-17T04:00:00Z Both ponder the consequences of the emotional inhibitions of English aristos, and mine them for humor. ‘King Charles III’ and ‘The Ruling Class’ in London 2015-01-28T05:00:00Z Whatever inhibitions I had about playing in front of Marshall or feeling creative and being able to express it were suddenly gone. The Princess and the Poconos 2022-08-09T04:00:00Z “There was no doubt about her experience and lack of inhibition. She spread herself and I entered her. She was not unresponsive,” he writes. What does Hollywood's reverence for child rapist Roman Polanski tell us? 2018-01-30T05:00:00Z She goes against her family’s wishes without inhibitions, eventually finding love with Ashish. New & Noteworthy, From Vivian Gornick’s Essays to No-Recipe Recipes 2021-03-09T05:00:00Z “I’m a very shy person and I figured doing something like this would help me get rid of my inhibitions and feel more comfortable in my own body,” Elizabeth said. I loved naked yoga: Maybe I am a naked person! 2014-04-08T23:00:00Z Haslam’s ability to conjure up swooping, heart-stopping environments comes from his “lifetime love of glamour” and, perhaps more important, his almost complete lack of inhibition. T Magazine: The Importance of Being Nicky 2014-04-10T16:46:16Z Three of my colleagues wisely stayed out of it, but my old friend Nina, a cellist with few inhibitions, brightly asked, “What would it sound like with no pedal?” There’s a Skeleton in My Closet, Literally 2017-06-09T04:00:00Z I did my best to never carry my son after I was drinking, but I worried that I’d lose my inhibitions. My agnostic AA 2012-06-20T18:28:00Z At least it was a chance to shed inhibitions — well, except for one. With a 6 a.m. dance party, D.C. cuts loose — a little 2015-06-03T04:00:00Z The “Fifty Shades” phenomenon has inspired a widespread loosening of inhibitions. Unexpected Lessons From ‘Fifty Shades of Grey’ 2015-02-26T05:00:00Z She sings like a shy person somehow released of inhibition by singing. Rickie Lee Jones and James Taylor 2015-06-16T04:00:00Z For the most part, festivals are a perfectly innocent place to act silly and brush off your inhibitions, without anyone else raising an eyebrow. Tonight I'm a rock'n'roll scribe: From arse-rags to ostriches 2010-10-07T11:20:00Z With no formal training, he approached clay without inhibition, making use of any technique that seemed appropriate. Dan Arbeid obituary 2010-11-22T18:24:00Z “You get rid of all your inhibitions. It’s license to play. You have this great freedom to be your true self. You get to be a rock star.” It’s the worst time in history to be a clown. They just want you to love them again. 2018-03-29T04:00:00Z At 2 a.m., the crowd thinned out, but those left, including Mr. Simons and his boyfriend, Jean-Georges d’Orazio, were dancing to thumping music with little inhibitions. Raf Simons and Todd Snyder Host Parties for Men’s Fashion Week 2017-07-12T04:00:00Z It is an album of spaciousness and claustrophobia, possibility and inhibition; at its best it feels fidgety and unstable, at its worst downcast and a bit predictable. Album review: Radiohead, 'The King of Limbs' 2011-02-20T05:48:13Z Benjamin is suffering from advanced memory loss and inhibition control, and he is behaving in ways that might, just might, turn dangerous. Theater Review: ‘Sorry,’ by Richard Nelson, at the Public Theater 2012-11-07T19:53:52Z With her team, she identified the fact that cells of naked mole rats display a very high degree of proximity inhibition – they don't like to grow close together. The weird and wonderful world of the naked mole rat 2013-07-13T23:05:33Z "Widow" soon became a cracking of a carapace, an unveiling of appetites, a loosening of inhibitions on every front. Review: Daffy humor and high artistry kick off Butoh festival 2011-06-04T16:45:05Z Now, one of Willems’s most gently adventurous creatures is about to shed its inhibitions on television. Naked No More: A TV Rodent Teaches Families About Tolerance 2022-06-29T04:00:00Z It's all good fun, particularly when the audience dancers really shed their inhibitions, as did one lucky woman on Wednesday. Tuxes, gowns, glitter and of course 'Revelations' 2012-11-29T22:26:08Z Falk, at times infuriating in his emotional inhibition, is a particularly compelling creation. As a Reporter, She Wrote About Business. As a Novelist, She Writes About Murder. 2019-01-31T05:00:00Z Those who commit sexual violence use alcohol to exploit their victims’ vulnerability and to lower their own inhibitions, said Laura Palumbo, communications director for the National Sexual Violence Resource Center. Recent Incidents Put a New Focus on Sexual Assault on Airplanes 2016-10-20T04:00:00Z This season she’s been casting off her inhibitions and entering her prime. U.S. Ballerinas Redefine an Art, but What About History? 2013-07-05T17:15:59Z And through most of the film, he seems free of inhibitions or remorse. Movie Review: ‘Act of Killing’ Re-enacts Indonesian Massacres 2013-07-18T16:01:22Z The alcohol was kicking in, and Jonathan’s inhibitions were coming down. Why I outed a Christian star 2012-08-12T16:00:00Z This lack of inhibition, she implied, enabled her to create scenes and situations that actually proved instructive. Jackie Collins, chronicler of lust and power, dies at 77 2015-09-20T04:00:00Z “The overall feeling was one of joy and a deliberate playfulness without inhibitions,” Ms. Stevenson said. Happily, Ever Open 2019-10-02T04:00:00Z Mr. Gurney, though, had by that time shed many of his own inhibitions as a playwright. A Patrician Older Gentleman Morphs Into an Angry Young Man 2017-06-15T04:00:00Z At the end of a dull ceremony, a chorus of 10-year-olds took to the stage and sang Over the Rainbow with joyful lack of inhibition and more feeling than most Oscar-winning performances. PS22: 'Fabulous. Perfect. Soulful. Amazing' 2011-03-16T22:00:01Z It leads, as Dr. James put it, to “a breakdown of ordinary social inhibitions” — such as controlling one’s explosive emotions. A Recipe for Air Rage 2014-09-25T04:00:00Z Following the then-fashionable ideas of the radical psychoanalyst Wilhelm Reich in identifying sexual inhibition with the authoritarian personality, “Investigation” also nods to Kafka with a closing quote from “The Trial.” A Cop Gets Away With Murder, Italian Style 2020-05-14T04:00:00Z The severe logic of Miller’s scene construction seems to constrain his visual sense, and the development of the drama seems to impose a moral inhibition on images for their own sake. Ridin’ Dirty: “Mad Max: Fury Road” 2015-05-21T04:00:00Z Our neurons are constantly going through cycles of excitation and inhibition that correspond with different mental states. New studies of brain activity explain benefits of electroconvulsive therapy 2023-11-16T05:00:00Z In experiments on both cell cultures and mice, it was possible to see how SMAD3 inhibition, together with the signals from the nerve cells, potentiates the tumour's ability to grow and spread. DNA organization influences the growth of deadly brain tumors in response to neuronal signals 2023-10-31T04:00:00Z “Brighter light releases more inhibition of eye growth,” which prevents the eye from growing too long, says Ian Morgan, a professor at Australia National University, whose research focuses on myopia. Why are so many children being diagnosed with myopia? 2023-11-01T04:00:00Z Microalgae, which form the foundation of the aquatic food chain, are most sensitive to photosynthesis reduction, suffering growth inhibition and cell deformation when exposed to a synthetic dye. Do or dye: Synthetic colors in wastewater pose a threat to food chains worldwide 2023-10-26T04:00:00Z Better yet, release your inhibitions and embrace the performance: Jump off the stage and move through the audience. Up your karaoke game with these 10 tips 2023-10-24T04:00:00Z Using standard laboratory procedures for assessing pain inhibition, they observed that the mice were much less sensitive to pain than rodents that were not stimulated with light. Soft optical fibers block pain while moving and stretching with the body 2023-10-19T04:00:00Z While inhibition is often very useful and allows us to adhere to social rules and therefore function appropriately in society, it also allows us to inhibit ourselves — our very identities. What kids teach us about gender 2023-10-17T04:00:00Z Heimes, director of the Institute for Creative and Therapeutic Writing in Darmstadt, explains how to overcome inhibitions and open up your inner world. Know Yourself Better by Writing What Pops into Your Head 2023-10-06T04:00:00Z “So if you block inhibition of muscle contraction, then you get excessive muscle contraction.” Celine Dion has stiff person syndrome. What exactly is it? 2023-10-03T04:00:00Z This would be to engineer the mosquitoes so that arbovirus infections trigger the loss of their tolerance mechanisms, perhaps via the inhibition of Ago2. Discovery in mosquitoes could lead to new strategy against dengue fever and other mosquito-borne vectors 2023-09-22T04:00:00Z Specifically, IDH2 inhibition affects a core metabolic process known as the TCA cycle, forcing the T cells to activate compensatory metabolic pathways. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z "It is the main player that balances excitation and inhibition in the brain," said lead author Chang Sun, Ph.D., a postdoctoral researcher in the Vollum Institute at Oregon Health & Science University. Structure of crucial receptor in brain development, function 2023-09-20T04:00:00Z But what can also lead to inhibitions is the fear of emotions or of your personal history—fear of confronting possibly painful topics. Know Yourself Better by Writing What Pops into Your Head 2023-10-06T04:00:00Z Diverse types of cancers can also accompany SPS because the same antibodies that the immune system releases to kill cancer cells can also block muscle inhibition. Celine Dion has stiff person syndrome. What exactly is it? 2023-10-03T04:00:00Z Its inhibition maintains the opening of those genes and promotes their transformation into long-lived memory CAR-Ts. Strengthening artificial immune cells to fight cancer 2023-09-20T04:00:00Z In the absence of IDH2 inhibition, those genes are kept under wraps, bolstering the terminally exhausted CD8+ T cell identity. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z The album is due this autumn and, in tandem with the music, there's a lack of inhibition to their presentation. Happiness bottled: Meet indie-pop supergroup Fizz 2023-09-04T04:00:00Z Young women asleep on airplanes offer an easy target for sexual predators who have lowered their inhibitions with alcohol, he added. FBI reports surge in men groping teenage girls, women on planes 2023-08-28T04:00:00Z They can miss the loss of feelings or inhibitions. What Happens when People with Dementia Commit Crimes? 2023-08-17T04:00:00Z As specific brain areas diminish in FTD, the researchers find, they release their inhibition, or control, of other regions that support artistic expression. A Rare Form of Dementia Can Unleash Creativity 2023-05-26T04:00:00Z These neurons operate on excitation or inhibition, and although nerve cells can vary in size and location, their communication with one another determines their function. Fundamentals of Biology 2015-01-01T00:00:00Z In some cases of enzyme inhibition, an inhibitor molecule is similar enough to a substrate that it can bind to the active site and simply block the substrate from binding. Concepts of Biology 2013-04-25T00:00:00Z There was a weird inhibition hanging over me. The working-class Belfast-born author trying to reinvent the post-Troubles novel 2023-05-19T04:00:00Z Clinically, it's impossible to know when dementia first starts taking root in a person's brain or when it begins chipping away at a person's empathy or inhibitions. What Happens when People with Dementia Commit Crimes? 2023-08-17T04:00:00Z A much larger potential inhibition, Rothenberg said, is the lengthy delays in issuing visas to foreign travelers. Mass shootings and gun violence in U.S. could damage 2026 World Cup bottom line 2023-05-16T04:00:00Z And the lowering of these inhibitions would further degrade our politics and reduce Americans’ faith in the justice system. Opinion | Trump’s indictment will warp our politics for years to come 2023-04-02T04:00:00Z When this happens, the enzyme is inhibited through competitive inhibition, because an inhibitor molecule competes with the substrate for binding to the active site. Concepts of Biology 2013-04-25T00:00:00Z Take “The Only Way to Love,” the album’s powerhouse about abandoning inhibitions. 4 concerts to catch in the D.C. area over the next several days 2023-02-22T05:00:00Z Some of my best work is where you could tell — I could tell — it had no inhibitions, that I am feeding you all instinct from my subconscious. Art should not abstract human emotion. Ferrari Sheppard can show you how it's done 2023-02-15T05:00:00Z Some, like Akansha, want to shed their inhibitions around dating, while others may be trying to relearn the rules around relationships. Valentine's Day: How fake dates help Indians find love and intimacy 2023-02-13T05:00:00Z Half the song is building up to grand and echoing drumming while Rogers’s voice matches the energy as it gradually loses any inhibitions. 4 concerts to catch in the D.C. area over the next several days 2023-02-08T05:00:00Z Feedback inhibition, where the end product of the pathway inhibits an upstream process, is an important regulatory mechanism in cells. Concepts of Biology 2013-04-25T00:00:00Z And in a theme park setting, that drives communication among friends, families and even strangers, as play helps lower inhibitions in the name of engagement. First look: Universal Studios Hollywood powers up with Super Nintendo World 2022-12-29T05:00:00Z In dreaming, children lose the inhibitions of hard reality. ‘Tis the season for Trump 2022-12-22T05:00:00Z “When I used cannabis in my workouts, I would find less inhibition to try something that looked really hard,” Clark said. Is working out while high L.A.'s next fitness craze? This trainer is betting on it 2022-12-05T05:00:00Z “A late adolescent of 18 to 20 years has the intellectual maturity of an adult but the emotional maturity and response inhibition of a younger teenager,” the court filing states. Condemned Missouri man asks Supreme Court to intervene 2022-11-10T05:00:00Z The restrained but intense physicality of Mescal’s performance finds intermittent release when Calum practices his tai chi moves or, in a sudden surrender of inhibitions, goes wild on the dance floor. Review: 'Aftersun,' one of the year's great debut films, is a piercing father-daughter story 2022-10-20T04:00:00Z The potion is a mere pretext that, as Lombardero puts it, “takes away their inhibitions.” An international collaboration brings Wagner back to Seattle Opera with ‘Tristan and Isolde’ 2022-10-11T04:00:00Z In doing this, he discovered that a VR environment swept away the inhibitions of many of his students wrestling with learning a new language. The LA kids who started behind and then flew ahead 2022-10-06T04:00:00Z Arbus used her camera, Sontag wrote, as a “kind of passport that annihilates moral boundaries and social inhibitions, freeing the photographer from any responsibility toward the people photographed.” Review | Diane Arbus was accused of exploiting ‘freaks.’ We misunderstood her art. 2022-09-26T04:00:00Z Substances can loosen a person’s inhibition to kill themselves, said Jennifer Stuber, associate professor of social work at the University of Washington, and raise their risk of suicide by causing shame or isolation. Her son was addicted to heroin and died by suicide. He’s not alone 2022-09-10T04:00:00Z The inhibition of cell division indicated that this square planar compound could be an anticancer agent. Chemistry 2019-02-14T00:00:00Z In some cases of enzyme inhibition, for example, an inhibitor molecule is similar enough to a substrate that it can bind to the active site and simply block the substrate from binding. Biology for AP Courses 2022-06-09T00:00:00Z It is responsible for a number of cognitive functions including prospective memory, focus and impulse inhibition. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z But what artist isn’t interested in the gaps between our instincts and inhibitions, between our private selves and the selves we present in public? Review | Diane Arbus was accused of exploiting ‘freaks.’ We misunderstood her art. 2022-09-26T04:00:00Z The online classes are essentially a digital replica of the dance center’s offerings, she says, and they’re geared to help the adult beginner or intermediate student ease past any inhibitions. Perspective | So you think I can dance? 2022-08-05T04:00:00Z Homeostasis in the body often works by using feedback inhibition, which is when a stimulus produces a response that opposes the original stimulus. Miller & Levine Biology 2018-01-01T00:00:00Z On the other hand, in noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than an allosteric site and still manages to block substrate binding to the active site. Biology for AP Courses 2022-06-09T00:00:00Z The latter function is uniquely important in preventing tumor growth: normal cells exhibit a phenomenon called “contact inhibition;” thus, extensive cellular contact with neighboring cells causes a signal that stops further cell division. Anatomy and Physiology 2013-06-19T00:00:00Z Early Western inhibitions about not upsetting Moscow by sending heavy weapons to Kyiv have been swept aside as gruesome details of alleged Russian war crimes and atrocities have emerged, backed up by satellite data. Nato summit: Five challenges for the military alliance 2022-06-28T04:00:00Z Topgolf staffers jokingly call its bar selections “swing juice” under the unproven premise that as one’s inhibitions loosen, so does one’s stroke. 6 insider tips for visiting Topgolf, L.A.'s popular driving range with unstuffy vibes 2022-06-21T04:00:00Z Still, those inhibitions persist, along with all the assumptions and prejudices that come with a socially conservative middle-class English background. Review: Emma Thompson gets (and gives) marvelous sex ed in ‘Good Luck to You, Leo Grande’ 2022-06-16T04:00:00Z What other molecules in the cell provide enzymatic regulation, such as allosteric modulation, and competitive and noncompetitive inhibition? Biology for AP Courses 2022-06-09T00:00:00Z Expanding the explanation of the withdrawal reflex can include inhibition of the opposing muscle, or cross extension, either of which increase the complexity of the example by involving more central neurons. Anatomy and Physiology 2013-06-19T00:00:00Z It’s the Broadway role this gifted “Saturday Night Live” alumna was born for; wait for the moment she is medicinally freed of her inhibitions. Review | A bountiful Broadway season ends with laughs, thanks to ‘POTUS’ 2022-04-29T04:00:00Z This inhibition reduces the risk for blood clots. Do strong heartburn drugs promote dementia? 2022-04-13T04:00:00Z Sex positivity is celebrated in progressive circles, with sexual adventurousness championed and inhibition often looked down on. Opinion | Straight People Need Better Rules for Sex 2022-04-07T04:00:00Z In a most efficient and elegant way, cells have evolved to use the products of their own reactions for feedback inhibition of enzyme activity. Biology for AP Courses 2022-06-09T00:00:00Z Negative feedback is characterized by the inhibition of further secretion of a hormone in response to adequate levels of that hormone. Anatomy and Physiology 2013-06-19T00:00:00Z And yet, with every atrocity apparently committed by Russian soldiers, Nato's resolve stiffens and its inhibitions melt away. Ukraine: Three ways this war could escalate and drag Nato in 2022-04-09T04:00:00Z Young and O’Connor inhabit their characters with the lack of inhibition and offhand attractiveness the roles require, although they feel as if they’ve been cast in a series of tableaus rather than a fleshed-out story. Review | ‘Mothering Sunday’ film makes for thoughtful but inert book adaptation 2022-03-30T04:00:00Z “We are trying to eliminate every obstacle, every excuse, every inhibition so that we’re motivating people to go forward with the effort to stay clean,” Gastfriend said. Federal government allows program to pay substance abusers for staying clean 2022-03-10T05:00:00Z Feedback inhibition, where the end product of the pathway inhibits an upstream step, is an important regulatory mechanism in cells. Biology for AP Courses 2022-06-09T00:00:00Z Finally, a neural stimulus occurs when a nerve impulse prompts the secretion or inhibition of a hormone. Anatomy and Physiology 2013-06-19T00:00:00Z "It has always been a matter of passing on information and taking the inhibition away from the people to dare and open their phones," he explains. The mobile phones you can take apart and repair yourself 2022-02-21T05:00:00Z So, when the last 16 begins this week, teams — in theory — should play freer of inhibitions. No away-goals rule means new era for Champions League 2022-02-15T05:00:00Z Posts tended to be a lot more edgy or tongue-in-cheek because there was no real inhibition about expressing yourself, which of course goes hand in hand with the college experience. Facebook isn’t fun anymore 2022-02-11T05:00:00Z The production of both amino acids and nucleotides is controlled through feedback inhibition. Biology for AP Courses 2022-06-09T00:00:00Z It is not until the placenta is expelled that this inhibition is lifted and milk production commences. Anatomy and Physiology 2013-06-19T00:00:00Z “The long play here is to alter the cultural inhibitions on registration.” Noncitizens skip the vote despite efforts to entice participation in local elections 2022-01-24T05:00:00Z His assault on our inhibitions was a gift. Perspective | Bob Saget’s wholesome gift of a dirty mouth 2022-01-10T05:00:00Z “It allows me to live more freely, with less inhibitions.” A surge of evangelicals in Spain, fueled by Latin Americans 2022-01-03T05:00:00Z Using an example, explain how enzyme feedback inhibition regulation regulates a cellular process. Biology for AP Courses 2022-06-09T00:00:00Z Awarding the Super Bowl to Las Vegas, though, is the biggest signal yet that the league embraced not only the so-called Sin City but has lost most of its inhibitions about sports gambling. N.F.L. Awards 2024 Super Bowl to Las Vegas 2021-12-15T05:00:00Z In the chorus, Collins sings, “Mixing glitter with my tears/ as my inhibitions disappear,” giving a gloomy story to a dance-friendly track. 4 concerts to catch in the D.C. area over the next several days 2021-11-30T05:00:00Z Drinking lots of alcohol may add to the party spirit, but in terms of Covid, it's risky because it lowers our inhibitions. Covid: Is it safe to hit the office Christmas party? 2021-11-30T05:00:00Z The charity advised people to look out for loss of balance, fatigue, lowering of inhibitions, visual problems, confusion, vomiting and unconsciousness as signs that someone might have been spiked. Injection spiking: New medical help from charity after rise in reports 2021-11-17T05:00:00Z Square lines, or the lines with no arrowheads, indicate inhibition of the product below the line. Biology for AP Courses 2022-06-09T00:00:00Z The coach, typically an aggressive strategist, preferred to play for overtime rather than protect a one-point lead against a team that needed to score — and thus would have fewer inhibitions. Analysis | In the new NFL, teams are scoring on two-minute drives like never before 2021-10-20T04:00:00Z It depresses the central nervous system, causing drowsiness and euphoria; and it can reduce inhibitions. Stephen Port: Serial killer was 'obsessed' with drug rape 2021-10-06T04:00:00Z “Anything we do that limits our inhibitions and makes us forget to be quite the perfectly compliant people we’re supposed to be has a risk,” she said. Puff, puff, don’t pass: How to smoke weed socially — and safely — in the COVID-19 era 2021-09-29T04:00:00Z However, many health experts remain concerned that people will lose their inhibitions in the excitement, causing a spike in cases. British music festivals ready to rock despite high COVID-19 cases 2021-08-27T04:00:00Z Apical dominance—the inhibition of lateral bud formation—is triggered by auxins produced in the apical meristem. Biology for AP Courses 2022-06-09T00:00:00Z The research focussed on “alerting, orienting, and executive inhibition” in particular. ‘These results are amazing’: Key mental abilities can improve during aging, study finds 2021-08-17T04:00:00Z In addition, similar to bouncing on a trampoline, the inhibition creates the ability to “rebound,” or respond more quickly, which may contribute to the rapid alternation of syllables. The Neuroscience of Taking Turns in a Conversation 2021-07-13T04:00:00Z “It’s a stem without a leaf. A stem with no inhibition.” Cauliflower and Chaos, Fractals in Every Floret 2021-07-08T04:00:00Z Lovingly filming Keough and Paige as they gyrate and twerk, the filmmaker isn’t reluctant to take pleasure in their physical beauty, and their lack of inhibitions have a liberated, vicarious thrill. Review | ‘Zola,’ a movie based on a tweetstorm, is squirmy, sordid, stylized, sexy — and smart 2021-06-30T04:00:00Z Exposure of the retina to light hyperpolarizes the rods and cones and removes their inhibition of bipolar cells. Biology for AP Courses 2022-06-09T00:00:00Z In contrast, both orienting and executive inhibition actually improved. ‘These results are amazing’: Key mental abilities can improve during aging, study finds 2021-08-17T04:00:00Z For example, neurons retain proteins that act as “brakes” to their growth, and their inhibition can substantially improve the capacity for regrowth. Readers Respond to the January 2021 Issue 2021-05-23T04:00:00Z Because we are nervous meeting new friends and need to release some inhibitions? Nonalcoholic spirits can seem like a marketing scam, but they have a place 2021-05-12T04:00:00Z “The unwillingness to come back when called” fits with that kind of dog, as does less inhibition, she said. Grumpy dogs outperform the friendlies on some learning tests 2021-05-07T04:00:00Z Progesterone assists in endometrial re-growth and inhibition of FSH and LH release. Biology for AP Courses 2022-06-09T00:00:00Z To help players lose their inhibitions, Dr. Robinson-Mosley starts them off by free writing, drawing or using whatever medium suits them. Don’t Take Your Head Out of the Clouds! 2021-04-10T04:00:00Z Stone said he couldn’t say for sure what techniques Roy was employing because he wasn’t there, “but he’s obviously using his words and sentence structure to lower her inhibitions.” Column: Can a scammer hypnotize you over the phone? Let's ask professional hypnotists 2021-03-30T04:00:00Z With participants identified only by a first name or perhaps even a pseudonym, inhibitions are removed. Math Can Help Build a Global Digital Community 2021-03-26T04:00:00Z Too many people losing their inhibitions in a crowded space, increasing the risk for transmission. Vaccinated lives: 5 health experts revel in simple pleasures 2021-03-10T05:00:00Z The inhibition of FSH and LH prevents any further eggs and follicles from developing, while the progesterone is elevated. Biology for AP Courses 2022-06-09T00:00:00Z Danez, the fourth player in the game, tucked into the corner of a seat, shouting out the kind of quick-fire jokes we know will unfurl when inhibition is cast aside. A World of Black Intimacy at the Card Table 2021-02-24T05:00:00Z Their ease and lack of inhibition comes from being childhood friends, as three self-confessed "theatre nerds" from Quincy, Illinois. Avenue Beat: How do the F2020 singers avoid becoming a one-hit wonder? 2021-01-16T05:00:00Z In it, the "Serendipity" actress is seen donning a stylish black suit affixed over a midriff-revealing black crop top as she sets her inhibitions aside and leans in for a drink of liquor. Kate Beckinsale recalls drinking tequila from ice luge in New Year’s Eve throwback ‘before COVID was invented’ 2020-12-31T05:00:00Z “After people drink for a while, perhaps they lose inhibition and judgment and so possibly a curfew might help,” Kuehl said. Weekend COVID-19 surge alarms L.A. officials amid talk of curfew, more actions 2020-11-15T05:00:00Z The most common method of enzyme regulation in metabolic pathways is via feedback inhibition. Biology for AP Courses 2022-06-09T00:00:00Z “PTS will appeal the administrative court’s decision on inhibition to the next instance,” the regulator said in a statement. Swedish telecoms regulator to appeal court decision on Huawei exclusion 2020-11-13T05:00:00Z "In fact, the only difference between Trump's style of politics and theirs was Trump's lack of inhibition." Obama: Trump "promised an elixir" for the "racial anxiety" of Americans spooked by a Black president 2020-11-12T05:00:00Z But he said the governor’s overarching approach, and the emphasis on quelling indoor drinking during late-night hours, when inhibitions drop, was appropriate. 19% Positivity Rate as Outbreak Accelerates in N.J.’s Largest City 2020-11-11T05:00:00Z At a certain point, two alcoholic beverages loosened my inhibitions and I reminded her of Trump's adoration for dictators like Vladimir Putin and his obvious desire to be more like them. Trump's supporters haven't budged, despite everything. WTAF? 2020-11-03T05:00:00Z How can various factors, such as feedback inhibition, regulate enzyme activity? Biology for AP Courses 2022-06-09T00:00:00Z But the prefrontal cortex doesn’t fully develop until adulthood and, according to Dr. Fields, inhibition and impulse control are among the PFC’s most complicated functions. The Science Behind Your Child’s Tantrums 2020-10-15T04:00:00Z But he said illegal house parties or hospitality settings "where alcohol is imbibed and inhibitions lax" appeared to be the places where the risks were greatest. 'No guarantee' pubs will reopen in two weeks 2020-10-11T04:00:00Z Baker wanted to be taken seriously as a man of state, not merely a political operative, and that, too, created inhibitions that don’t seem to apply in the Trump era. Review | James Baker, master of a bygone Washington 2020-09-30T04:00:00Z He said France was extremely concerned by “warlike messages” from Turkey “which essentially remove any of Azerbaijan’s inhibitions in reconquering Nagorno-Karabakh”. Tensions mount as Azerbaijan and ethnic Armenian forces fight for fourth day 2020-09-30T04:00:00Z However, most of the control of the respiration processes is accomplished through negative feedback inhibition of specific enzymes that respond to the intracellular concentrations of ATP, ADP, NAD+, and FAD, etc. Biology for AP Courses 2022-06-09T00:00:00Z Allies expect no such inhibitions against Mr. Trump, a man whose approach to politics and power plainly offends Mr. Biden at a visceral level. How Joe Biden Is Preparing for the Biggest Debate of His Life 2020-09-28T04:00:00Z Therefore, it is possible that the active protein is normally inhibited and is released from inhibition only on phage infection. Bacteria sting viral invaders 2020-09-27T04:00:00Z “Once you have some alcohol in you, you lose some inhibitions and your judgment,” Dr. Swartzberg said. Movies and Museums Are Coming Back. Should You Go? 2020-09-26T04:00:00Z The aim is to dilute, to the point of disappearance, inhibitions about government using group entitlements — racial, ethnic and gender — for social engineering. Opinion | California shows how unchecked progressives inflict progress 2020-09-15T04:00:00Z Metabolic pathways are economical due to feedback inhibition. Biology for AP Courses 2022-06-09T00:00:00Z When people communicate through technology rather than in person, inhibitions too often break down and they get testy. Chaos and incivility ruled the last day of California's legislative session. Blame Zoom 2020-09-03T04:00:00Z But the poison's effect - inhibition of the enzyme cholinesterase in the body - "was confirmed by multiple tests in independent laboratories". Navalny and Russia’s arsenal of exotic poisons 2020-08-25T04:00:00Z I understand the urge that drives the lack of inhibition. Column: Is it time for L.A. to become a real party pooper to fight the spread of COVID-19? 2020-08-17T04:00:00Z Feedback inhibition occurs when the product of a metabolic pathway diminishes its own production by triggering a decrease in the activity of a key enzyme in the pathway. Structure of a lipopolysaccharide regulator reveals a road to new antibiotics 2020-08-11T04:00:00Z Explain the function of telomerase in the development of stem cells and cancer cells, and the inhibition of telomerase in programmed cell death or apoptosis. Biology for AP Courses 2022-06-09T00:00:00Z And bars tend to, well, encourage drinking, and drinking, in turn, lowers inhibitions, such as the need to maintain your distance. Bars, strip clubs and breweries discover how to survive during the pandemic: Reopen as restaurants 2020-07-30T04:00:00Z My inhibitions, despite my best efforts to ignore them, had effectively defeated me; I put the novel aside. Perspective | How literature can mirror our complicated desires 2020-07-31T04:00:00Z Inhibition of either protein blocked stem-cell proliferation, but only MAL inhibition led to loss of the ‘stretched’ molecular state in a subset of stem cells. Stretch exercises for stem cells expand the skin 2020-07-28T04:00:00Z “If you’re in a group of 50 or 100 people where folks are inebriated, inhibitions are reduced.” Last call: Colorado prohibits serving booze after 10 p.m. 2020-07-21T04:00:00Z Figure 6.17 Competitive and noncompetitive inhibition affect the rate of reaction differently. Biology for AP Courses 2022-06-09T00:00:00Z Alcohol lowers inhibitions, so people forget precautions, said Natalie Dean, an infectious diseases expert at the University of Florida. Closing bars to stop coronavirus spread is backed by science 2020-07-02T04:00:00Z I didn’t really expect to lose touch with my inhibitions when stepping into a dining room for the first time since March, when they were closed to prevent the spread of the novel coronavirus. Perspective | I was anxious to go back to a restaurant. But once I did, I remembered the real reasons I love them. 2020-06-26T04:00:00Z Consuming alcohol reduces inhibitions, which leads to less mask-wearing and social distancing, health officials warn. What you need to know about the coronavirus right now 2020-06-29T04:00:00Z Golfers at this level are not accustomed to inhibition in their lives. Watney's Covid case raises questions about PGA Tour's pandemic policy | Ewan Murray 2020-06-20T04:00:00Z The most common method by which cells regulate the enzymes in metabolic pathways is through feedback inhibition. Biology for AP Courses 2022-06-09T00:00:00Z The demonstrators themselves said it: America’s turmoil has erased an inhibition in France. George Floyd Protests Inspire Fresh Scrutiny of Policing in Europe, Too 2020-06-12T04:00:00Z Another concern about drinking holes: As people become inebriated, they let their guard down and lose their inhibitions. How to Navigate Your Community Reopening? Remember the Four C’s 2020-06-06T04:00:00Z The logic is that — when police don their armor — it can reduce officers’ inhibitions about using force, since they are harder to identify by name. Police turn more aggressive against protesters and bystanders alike, adding to disorder 2020-05-31T04:00:00Z Alcohol does break down inhibitions and people get much more tactile when they're drunk. A practical guide to how to socialise now 2020-05-29T04:00:00Z The most common method by which cells regulate the enzymes in metabolic pathways is through feedback inhibition. Biology for AP Courses 2022-06-09T00:00:00Z However, the team found that the enzyme escapes this inhibition when bound to an exosome. Research round-up: COPD 2020-05-12T04:00:00Z Lipkin said he is most worried about two things: the reopening of bars, where people crowd together and lose their inhibitions, and large gatherings such as sporting events, concerts and plays. On Mother's Day, world leaders try optimistic tone as coronavirus spreads 2020-05-10T04:00:00Z His malodorous insults combined with his inebriated loss of inhibitions prompts the doctors to use one of our precarious rapid Covid swabs to rule him out as a danger to staff. Six swabs a shift: hospital units battle over precious rapid Covid tests 2020-05-06T04:00:00Z The authors also report that the inhibition or ablation of corticotropin-producing neurons in either of the two brain regions impaired the formation of plasma cells after antigen injection. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z Feedback inhibition benefits the cell by blocking the production of the reactants by changing the configuration of enzymes. Biology for AP Courses 2022-06-09T00:00:00Z The authors find that inhibition of this pathway, using drugs or by genetic approaches, reverses this immune evasion in animal models of pancreatic cancer. Pancreatic cancer hidden in plain sight 2020-04-21T04:00:00Z The patients also experienced heightened anxiety and inhibition, along with diminished reward signaling in their brains. Rethinking anorexia: Biology may be more important than culture, new studies reveal 2020-04-09T04:00:00Z Publicans reported “real difficulty in implementing ... guidelines on social distancing ... as pubs are specifically designed to promote social interaction in a situation where alcohol reduces personal inhibitions,” the statement said. Last orders... Ireland closes all pubs on eve of St Patrick's Day 2020-03-15T04:00:00Z In experimental animals, very precise stimulation or inhibition of neuronal firing can be achieved by optogenetics. Mind Reading and Mind Control Technologies Are Coming 2020-03-11T04:00:00Z Feedback inhibition benefits the cell by blocking the production of the products by changing the configuration of reactants. Biology for AP Courses 2022-06-09T00:00:00Z Hence it suggests how a Warren administration would operate without constitutional inhibitions. Opinion | A judicial rebuke for a heedless Congress? 2020-02-27T05:00:00Z Such a rare encounter made Angel feel happy and heady and her inhibitions began to slip away from her. 'How do I convince the Home Office I'm a lesbian?' 2020-02-25T05:00:00Z I was in my late teens when I discovered what alcohol could do: quash my inhibitions; kindle false intimacies; provoke brilliant revelations that I soon forgot. What Does It Mean to Have a Serious Drinking Problem? 2020-01-31T05:00:00Z For example, men with metastatic prostate tumours who responded to checkpoint inhibition have been found to have lower levels of a microbe called Akkermansia muciniphila in their stool than did men who did not respond. Fighting cancer with microbes 2020-01-28T05:00:00Z Feedback inhibition benefits the cell by blocking the production of the products by reducing the reactants. Biology for AP Courses 2022-06-09T00:00:00Z First, people lower their inhibitions, saying and doing things that were previously considered beyond the pale. Donald Trump and his demons: Why the assault on democracy will get worse 2020-01-28T05:00:00Z The 62-year-old said she’s happiest with the fact she can let go of her inhibitions with her “friend” and voice all of her desires. Fran Drescher says her 'friend with benefits' keeps her going: 'Of course we have sex' 2020-01-23T05:00:00Z The calcium channel’s β-subunit was the prime suspect as the target of Rad inhibition. Suspect that modulates the heartbeat is ensnared 2020-01-21T05:00:00Z After learning, experimenting and dawdling with friends in Cork, all it took was NKC’s raucous parties to dissolve their collective inhibition. 'No Fiat 500 techno!': why electronic music in Cork is popping off 2020-01-22T05:00:00Z This inhibition of the enzyme essentially increases neurotransmission at synapses that release acetylcholine. Biology for AP Courses 2022-06-09T00:00:00Z As inhibitions lower, people who would not themselves use force are willing to excuse it in others. Donald Trump and his demons: Why the assault on democracy will get worse 2020-01-28T05:00:00Z Participants are given 5 ½-inch sheets of watercolor paper that is already sprinkled lightly with ink to remove their inhibitions about approaching a blank page, Lyons said. Woman to exhibit ‘key idea’ project across the country 2020-01-14T05:00:00Z And, crucially, the kingpins have few inhibitions about over-exploiting water resources, jeopardizing the environment and their cities’ long-term vitality. The Merchants of Thirst 2020-01-11T05:00:00Z He puts that lack of inhibition on display before every home game. Dabo Swinney Has a Vision to Sell You 2020-01-10T05:00:00Z This inhibition sharpens edges and enhances contrast in the images by making regions receiving light appear lighter and dark surroundings appear darker. Biology for AP Courses 2022-06-09T00:00:00Z “I think it’s highly available already, and this will lower inhibitions to trying it because it’s ‘legal’.” Editorial Roundup: Excerpts from recent Wisconsin editorials 2019-12-30T05:00:00Z Shopping when your inhibitions are down means you’re generally not reading the fine print. Last-minute gift buying can drain your wallet 2019-12-18T05:00:00Z Well, shopping when your inhibitions are down means you’re generally not reading the fine print. Last-minute gift buying: 5 scenarios that will drain your wallet 2019-12-17T05:00:00Z By contrast, T cells that express REGNASE-1 produce a short-lived antitumour response that fails to overcome tumour inhibition of the immune response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z Glucocorticoids also have anti-inflammatory properties through inhibition of the immune system. Biology for AP Courses 2022-06-09T00:00:00Z “Holly is great with people of any kind. She’s got no inhibitions at all.” Evansville Rescue Mission leads to special friendship 2019-12-08T05:00:00Z The labour itself was something of a learning curve, if only for losing inhibitions about personal privacy. Planning a baby at 16: 'My waters broke in McDonald's' 2019-11-20T05:00:00Z Morgan told me he has never felt fully British, which may explain his lack of inhibition when it comes to writing about the country’s most powerful people. How the Man Behind ‘The Crown’ Made the Monarchy Relevant Again 2019-11-06T05:00:00Z “This paper is the first to show that the response to glutamine inhibition in T cells and cancer cells is different.” Revamped cancer drug starves tumors in mice 2019-11-07T05:00:00Z How does enzyme feedback inhibition benefit a cell? Biology for AP Courses 2022-06-09T00:00:00Z This is done by applying a nearly painful stimulus that activates pain inhibition and reduces a clinical pain. Treating Chronic Pain in the Right Place: Remotely 2019-10-25T04:00:00Z Consistent with these findings, previous work7 indicates that macrophage activation triggered by IFN-γ from CD4 T cells leads to the inhibition of tumour growth. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z "I loved every sweaty moment in the rehearsal studio pushing myself past so many inhibitions and insecurities, and laughing my way through it all with my buddies." Sailor Brinkley-Cook's 'DWTS' elimination left Christie Brinkley 'heartbroken' 2019-10-23T04:00:00Z “What you see, in their search histories,” he said, “is that they learn how to evade law enforcement, they become more confident, and they begin to use cognitive distortions to overcome their moral inhibitions.” Preying on Children: The Emerging Psychology of Pedophiles 2019-09-29T04:00:00Z Feedback inhibition benefits the cell by blocking the production of the products by changing the configuration of enzymes. Biology for AP Courses 2022-06-09T00:00:00Z “What you see, in their search histories,” he said, “is that they learn how to evade law enforcement, they become more confident and they begin to use cognitive distortions to overcome their moral inhibitions.” Preying on Children: The Emerging Psychology of Pedophiles 2019-09-29T04:00:00Z His own recent death sentence, it would seem, has inspired him to cast all inhibitions aside. Review: A boxer takes on the mob in Takashi Miike's joyous thriller-romance 'First Love' 2019-09-26T04:00:00Z As author Erin Carlson states, “Most of all, she represents a meaningful goal for women: the courage to shed fear and inhibition and live a big, bold, authentic life.” Review: Lively ‘Queen Meryl’ crowns Streep as acting’s best 2019-09-23T04:00:00Z They all keep the vibe astral with cartoonish dance manoeuvres devoid of inhibition and, in some cases, motor skills. Unleash the sesh gremlins! Sunset Campout, California's clubbing paradise 2019-08-12T04:00:00Z This is a type of end product inhibition, since ATP is the end product of glucose catabolism. Biology for AP Courses 2022-06-09T00:00:00Z For example, in animal studies, loss of merlin expression is associated with cancer-cell vulnerability to inhibition of a protein called focal adhesion kinase13. Cancer-cell death ironed out 2019-07-23T04:00:00Z One explanation of this superiority is that speakers of two languages are continually inhibiting one of their languages, and this process of inhibition confers general cognitive benefits to other activities. Can learning a foreign language prevent dementia? 2019-07-21T04:00:00Z I loved what Anais Nin had to say: “Something is always born of excess: great art was born of great terrors, great loneliness, great inhibitions, instabilities.” After falling for a con artist, I lost trust in the world – but I am anything but a damaged soul 2019-07-17T04:00:00Z Of course, Len was known in their circle to have issues with inhibition. “She Said He Said” 2019-07-15T04:00:00Z They include losing your inhibitions, and becoming who you truly are when you're not being polite or trying to please others. Why this man became a hermit at 20 2019-07-12T04:00:00Z As moral inhibitions are swept away, innocents are exposed to unspeakable horror. Opinion | We’re in an ‘Age of Impunity.’ It will have consequences for us all. 2019-07-07T04:00:00Z “The dramatic protection that TREM1 inhibition exerts on brain and gut raises the possibility that ‘turning down the gain’ of the immune system may be beneficial in stroke,” Iadecola adds. New Method for Tackling Stroke Restrains an Overactive Immune System 2019-07-02T04:00:00Z Skills such as concept formation, abstraction and mental agility begin to falter, as does response inhibition, defined as the ability to inhibit an automatic response in favor of producing a novel one. Opinion | We need a mandatory retirement age for professors 2019-06-28T04:00:00Z The film also offers a moving depiction of Hogg as a would-be artist, delineating the kinds of inhibition that can hinder even a person born to privilege. Joanna Hogg’s Self-Portrait of a Lady 2019-05-13T04:00:00Z In particular, try the scene in which Herzog, casting aside all inhibition, exclaims, in his matchless tones, “We luff you. I luff you.” The Silly Satisfactions of “Long Shot” 2019-05-03T04:00:00Z The day progresses, and the Sunshine State heat and humidity begins beating down, sweating out the last drops of inhibition as the party moves into marathon mode. 'It's 2001 meets Alice in Wonderland': Get Lost, the 24-hour Miami rave 2019-04-03T04:00:00Z He also notes that if TREM1 inhibition prevents increased permeability of the gut following a stroke, individuals would be at lower risk for infection, a major cause of death. New Method for Tackling Stroke Restrains an Overactive Immune System 2019-07-02T04:00:00Z Remember, too, that alcohol lowers inhibitions and may interfere with your eat-healthy goals. How to avoid those unhealthy dishes at restaurants 2019-03-29T04:00:00Z War hunger and war hatred are parts of the same cycle of mass arousal and inhibition. How the South Won the Civil War 2019-04-01T04:00:00Z Many women have cast off expectations and inhibitions and gone straight for the laughs. Opinion | My Glamorous Life as a Movie Star in Control-Top Pantyhose 2019-03-16T04:00:00Z They jealously guard it, and if anyone challenges them, they lose all inhibitions. What animals can teach us about politics 2019-03-12T04:00:00Z The tinsel mammals suggested something about the appeal of Lange’s songs, allowing his fans to set aside their inhibitions, safely anonymous inside the radiant costumes. Helado Negro’s New Songs Bask in a Sense of Discovery 2019-03-11T04:00:00Z “It was my first traumatic realization that all this ends, and it instilled in me some impulse to push past my fears and inhibitions and try to go be a filmmaker.” Bill Hader Kills 2019-03-11T04:00:00Z The authors’ subsequent in-depth analysis revealed a much more complex pattern than a general inhibition of neural activity. The influence of a single neuron on its network 2019-03-05T05:00:00Z But the brain-imaging studies found that inhibition of the transporter increases sharply with addition of the drug and, by extension, also drops sharply with any reduction in dosage. How to Quit Antidepressants: Very Slowly, Doctors Say 2019-03-06T05:00:00Z Newton et al. and Mizuhashi et al. provide evidence that the inhibition of Hedgehog signalling reduces the length of chondrocyte columns. A newly discovered stem cell that keeps bones growing 2019-02-26T05:00:00Z “He’s entering this campaign with much fewer inhibitions than in the past,” Mr. Plesner said. Netanyahu Sparks Outrage Over Pact With Racist Party 2019-02-25T05:00:00Z They found that some of the types of cancer cell tested were highly sensitive to SCD inhibition, and either stopped dividing or died, whereas others were insensitive and continued to divide. Tumours use a metabolic twist to make lipids 2019-02-05T05:00:00Z The findings of the current study suggest that chronic inhibition of autophagy and a failure to properly clear protein aggregates might be involved. Signalling protein protects the heart muscle from pressure-related stress 2019-01-29T05:00:00Z Dreams in contrast, are characterized by primary and secondary sensory cortices activation, coupled with disrupted recruitment of the frontal cortex, gate keeper of important higher-order functions like inhibition. Why Do We Sleep? 2019-01-25T05:00:00Z One attractive aspect of this model is that it provides a mechanism for reversing splicing inhibition. Intron RNA sequences help yeast cells to survive starvation 2019-01-15T05:00:00Z Optogenetic inhibition of this neural pathway turned persevering mice into renouncing mice. Brain circuits of compulsive drug addiction identified 2018-12-18T05:00:00Z They note that sapienate is detectable in tumours from mouse models of liver cancer, and that, in these tumours, FADS2 expression correlates with resistance of the cancer cells to SCD inhibition. Tumours use a metabolic twist to make lipids 2019-02-05T05:00:00Z A seizure is a period of runaway electrical activity during which the normal balance between excitation and inhibition is lost. Gene therapy targets epilepsy 2018-12-11T05:00:00Z Casinos ply customers with free alcohol to loosen inhibitions, and clocks are nowhere to be found. Nonprofit bets Asian-American students can learn to avoid unhealthy gambling 2018-12-10T05:00:00Z To be state of the art, shed your inhibitions: Communicate only via twitter. How to manage Trump: Modeling madness at the G20 2018-11-30T05:00:00Z In contrast to the temporary reversal observed after optogenetic inhibition of OFC neurons projecting to the dorsal striatum, these changes in synaptic strength induced a behavioural switch that persisted for six days. Brain circuits of compulsive drug addiction identified 2018-12-18T05:00:00Z However, human cancer cells grown in vitro that were insensitive to SCD inhibition were killed by a combination of SCD inhibition and depletion of FADS2. Tumours use a metabolic twist to make lipids 2019-02-05T05:00:00Z Not every form of lymphoma has been equally responsive to BTK inhibition. Precision therapies take aim at non-Hodgkin’s lymphoma 2018-11-13T05:00:00Z Sometimes, Dr. Stanton said, part of his job is convincing academic scientists “to lower their inhibitions.” The Mysteries of Animal Movement 2018-11-05T05:00:00Z "He told her that if she wanted to be an actress, she would have to be comfortable doing whatever the director told her to do - including losing her inhibitions and getting naked", the documents state. Weinstein accused of assaulting 16-year-old 2018-11-01T04:00:00Z However, this behavioural switch was only temporary: when optogenetic inhibition was turned off, the compulsive behaviour resumed in persevering mice. Brain circuits of compulsive drug addiction identified 2018-12-18T05:00:00Z Moreover, consistent with this possibility, the inhibition of tumour growth observed after combined depletion of SCD and FADS2 in mice was only moderate. Tumours use a metabolic twist to make lipids 2019-02-05T05:00:00Z For instance, Swetnick in her previous statement had accused Kavanaugh and his friends of “spiking” the punch at parties with drugs or grain alcohol so girls would lose their inhibitions. NBC faces scrutiny for interview with Kavanaugh accuser 2018-10-02T04:00:00Z “It was the alcohol, you might find on the evidence, contributed to the lack of inhibition on the part of the defendant,” the prosecutor said. Teacher had sex with teenage pupil in plane toilet, court told 2018-10-01T04:00:00Z She also claims that Kavanaugh would attempt to “spike” the “punch” at these parties with drugs “so as to cause girls to lose their inhibitions and their ability to say ‘no.’” Kavanaugh backed by 60 who attended Georgetown Prep, sister schools 2018-09-26T04:00:00Z She went on to allege that Judge and Kavanaugh would "spike" drinks at house parties with drugs and alcohol "so as to cause girls to lose their inhibitions and their ability to say 'No.'" Kavanaugh confirmation derailed by sexual misconduct allegations: A list of his accusers 2018-09-26T04:00:00Z Paradoxically, much of this inhibition is facilitated by other immune cells, which are recruited by the glioma for their ability to pacify tumour-killing immune cells. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z “We believe the defendants used their good looks and charms to lower the inhibitions of their potential prey,” Rackauckas said. More than a dozen victims accuse California surgeon, girlfriend of rape; called 'Bonnie and Clyde' team 2018-09-22T04:00:00Z What he wants instead is “good mood, confidence, focus, energy, willpower, stress resilience, brainpower, calm, health, longevity, removal of social anxieties and inhibitions. All the time. With minimal investment of time and minimal risk.” Extreme biohacking: the tech guru who spent $250,000 trying to live for ever 2018-09-21T04:00:00Z Others might not protect themselves when they are under the influence and their inhibitions are down. STDs such as syphilis and gonorrhea rising rapidly in Maryland 2018-09-20T04:00:00Z "We believe the defendants used their good looks and charm to lower the inhibitions of their potential prey," said District Attorney Tony Rackauckas said. US couple deny mass drug rape allegations 2018-09-19T04:00:00Z “We believe the defendants used their good looks and charm to lower the inhibitions of their potential prey,” Rackauckas said, releasing an array of information about many locations and events associated with Robicheaux and Riley. Grant Robicheaux, doctor on Bravo’s ‘Online Dating Rituals of the American Male,’ charged in rapes 2018-09-18T04:00:00Z "We believe the defendants used their good looks and charms to lower the inhibitions of their potential prey," he said, reports KTLA-TV. US couple suspected of multiple drug rapes 2018-09-18T04:00:00Z “The one thing Hollywood needs right now is people losing their inhibitions at a work function,” he quipped. Emmys 2018: An award diversity showing and an epic proposal 2018-09-18T04:00:00Z But Chen et al.3 show that, in mice with an SCI, excessive activity in inhibitory neurons increases inhibition of the circuits to a level that renders them dormant. Reducing neuronal inhibition restores locomotion in paralysed mice 2018-09-16T04:00:00Z The goal was to energize a circuit that governs response inhibition, thereby halting a useless cycle of activity. Can brain-stimulating implants treat some severe cases of autism? 2018-09-14T04:00:00Z But there were forces militating against taking the plunge, even beyond his inhibitions. How the Composer George Benjamin Finally Found His Voice 2018-09-10T04:00:00Z And, although she may have lost her inhibitions, her feelings about her body remain mixed. 'Every step I take is a defiance': Rain Dove on modelling, Asia Argento and 'gender capitalism' 2018-09-10T04:00:00Z A celebration of freedom characterized by wild dancing and the loss of inhibitions was now surrounded by police barricades and patrolled by thousands of officers under the glare of the sun. You Can’t Keep the Jab Jab Down: J’Ouvert Dancers, Smeared in Motor Oil, Feel the Rhythm 2018-09-03T04:00:00Z This restores the balance between excitation and inhibition, enabling relay circuits to pass information from the brain to executive centres and so leading to the recovery of basic locomotor movements such as walking. Reducing neuronal inhibition restores locomotion in paralysed mice 2018-09-16T04:00:00Z I relay this by way of transparency into Jones’s inhibitions, which were relaxing rapidly. The N.F.L. Stiff-Armed Trump. Now He Is Heckling From the White House. 2018-08-28T04:00:00Z The point is less to let off steam or lose your inhibitions than to improve your mind. Opinion | How and Why Silicon Valley Gets High 2018-08-23T04:00:00Z But Mr. Carbonetti said a sudden interest in inappropriate and illegal material after a traumatic brain injury is not unheard of, a side effect involving the loss of inhibition. A New Wife, a Secret Past and a Trail of Loss and Blood 2018-08-21T04:00:00Z Kids should also know that screens interfere with sleep and that inhibitions drop when people are tired — and that is when teens tend to get into trouble online. Here’s what parents should tell kids before the school year begins 2018-08-10T04:00:00Z The removal of inhibitions provided by drink and drugs only adds to this. Cruel Britannia: how banter became a humiliation game | Oscar Rickett 2018-07-31T04:00:00Z “It laid some very heavy inhibitions on me,” she complained. Wow! Wow! Wow! Wow! 60 unbelievable facts about Kate Bush 2018-07-28T04:00:00Z Everyone sheds conscience and inhibition to fulfil desires and avenge injuries. Yan Lianke’s dark satire of modern China 2018-07-26T04:00:00Z One area to explore is inhibition of CMPK2 during inflammation, and other parts of the pathway that the authors uncovered are worth considering as targets, too. Newly made mitochondrial DNA drives inflammation 2018-07-24T04:00:00Z In May, Bilousova’s team showed that this inhibition blocks the transfer of tau aggregates between neurons in culture, and that cambinol reduces the enzyme’s activity in the brains of live mice10. Ways to stop the spread of Alzheimer’s disease 2018-07-24T04:00:00Z The mechanism may involve contact inhibition, the tendency of cells to stop dividing when squeezed tightly by other cells. Rarity of cancer in elephants may help explain cancer in humans 2018-07-20T04:00:00Z Cespedes also ran the bases without inhibition as he scored from second on a single by Michael Conforto in the fifth inning. Mets Get Yoenis Cespedes Back, and He Homers to Help Beat the Yankees 2018-07-20T04:00:00Z In a mouse model4 of tumour progression to brain sites, inhibition of the protein VEGF-A hinders a crucial early switch needed for the formation of tumour blood vessels. Leukaemia follows a blood-vessel track to enter the nervous system 2018-07-17T04:00:00Z A similar inverted U-shaped curve over the life span is also seen with a phenomenon known as response inhibition—the ability to suppress one’s initial response to something. The Art of Lying 2018-07-11T04:00:00Z By contrast, pharmacological inhibition of the cell cycle increased artery formation in an ex vivo experiment. Coronary artery development, one cell at a time 2018-07-03T04:00:00Z Devastated on the pitch, trailing 3-0 after a performance riddled with anxiety and inhibition, with the minutes ticking down on Mexico’s World Cup Javier Hernández did the only thing that really mattered in the circumstances. Sweden cruise to victory over Mexico as both qualify for World Cup last 16 2018-06-27T04:00:00Z Tissue in the human post-stroke brain may recover at different rates and therefore may not benefit from complement inhibition at the same time, Buchan explains. Targeting Inflammation May Protect and Restore the Brain after Stroke 2018-06-13T04:00:00Z Yao and colleagues analysed gene expression in cancer cells to identify genes whose expression decreased as a result of PI3K inhibition. Leukaemia follows a blood-vessel track to enter the nervous system 2018-07-17T04:00:00Z At the same time, we must suppress the truth so that we do not spill the beans—that is, we must engage in response inhibition. The Art of Lying 2018-07-11T04:00:00Z “There is something about her pose; the exuberance for life without inhibition – it expresses an uninhibited sense of our own vibrancy.” A hot dog bus and a snowman in June: the best public art to see in the US this summer 2018-06-11T04:00:00Z But it inhibits bipartisanship among elected officials, and that inhibition is getting in the way of governance. Excerpts from recent Minnesota editorials 2018-06-11T04:00:00Z Thousands of women have shed their inhibitions and their clothes on a secluded beach in Ireland for a world-record setting “skinny dip” to raise funds for a children’s cancer charity. Women break world skinny dipping record with Ireland beach swim 2018-06-09T04:00:00Z Dunn, despite his “no inhibitions” encouragement, insists that description is not accurate. At Nuit Blanche, 1920s Parisian decadence meets immersive dinner theater for a grown-up night out 2018-06-01T04:00:00Z The Dutch researchers described these traits — gloominess combined with emotional inhibition — as typifying the distressed, or Type D, personality. Are You a ‘Type D’ Athlete? Relax and Ask for Help 2018-05-23T04:00:00Z Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Pancreas regeneration 2018-05-15T04:00:00Z The chief constable has no such inhibitions about nailing Saoradh's colours to the New IRA mast. New dissidents hoping to exploit Brexit 2018-05-15T04:00:00Z She said symptoms included slurred speech, unsteadiness, and looking drunk, but without the lack of inhibition associated with alcohol. Children as young as 11 abusing Xanax drug 2018-05-03T04:00:00Z Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Architecture of an HIV-1 reverse transcriptase initiation complex 2018-04-24T04:00:00Z Presumably, then, lPBN neurons act to suppress appetite in threatening conditions, when eating might be dangerous, whereas their inhibition by input from AgRP neurons supports feeding in conditions of inflammatory pain. Hunger is a gatekeeper of pain in the brain 2018-04-22T04:00:00Z He and his wife had a two-year-old child and one-month-old baby, and Joy had taken to unwinding with a couple of drinks in the evening which, he admits, lowered his inhibitions. Sexual addiction, desire and dopamine hits 2018-04-22T04:00:00Z This is because the feedback loop in the hypothalamus, which controls the release of cortisol, is least vulnerable to inhibition in the morning. Medicine’s secret ingredient — it’s in the timing 2018-04-16T04:00:00Z “It lowered my inhibitions. I felt euphoria. I couldn’t focus without it.” EXCHANGE: Man who abused opioids now inspires audiences 2018-04-14T04:00:00Z In any organism, from bacteria to fish to modern Americans, behavioral inhibition wires us to look before we leap. Why Everyone Is Insecure (and Why That's Okay) 2018-04-12T04:00:00Z Similar principles at work in other brain regions might further support unaltered food intake during inflammatory pain in hungry mice — for example, by promoting pain inhibition during meals. Hunger is a gatekeeper of pain in the brain 2018-04-22T04:00:00Z In her book, Coles quotes cyberpsychologist Mary Aiken on the dangers of losing your inhibitions more easily when you are in the “immersive environment” of cyberspace — a space designed by men. Opinion | What’s Lust Got to Do With It? 2018-04-07T04:00:00Z It would be a few days before I adjusted and could lose my inhibitions to also scream, and only on the last day did I cry. Screaming, hitting, sweating: how my Wild Wild Country retreat led to contentment | Brigid Delaney's diary 2018-04-04T04:00:00Z She worked with a music therapist, and her inhibitions about unleashing her eclectic range faded. Voices of the City: Experimental vocalist Carmina Escobar uses her voice to explore herself and others 2018-03-29T04:00:00Z There’s more: Behavioral inhibition and social anxiety are a package deal. Why Everyone Is Insecure (and Why That's Okay) 2018-04-12T04:00:00Z With most people, it’s not so much that our social skills are lacking, it’s that our inhibitions get in the way and prevent us from using our social skills. A psychologist explains how to beat social anxiety 2018-03-21T04:00:00Z One consequence of that disruption is a lessening of what is called “cognitive inhibition.” Opinion | In Praise of A.D.H.D. 2018-03-17T04:00:00Z The group that played the nonviolent game showed more activity in the prefrontal parts of the brain, which are involved in inhibition, concentration and self-control. Trump reopens a seemingly settled video-game debate 2018-03-07T05:00:00Z His dad, Joe, remembers his young son performing in a country medley in Alabama with no inhibitions. Teacher’s passion for theater helped free him of heroin 2018-03-02T05:00:00Z Dajani and Panter-Brick quickly found that their desire for rigor and clear outcomes ran up against teenage inhibitions and logistical snags. In war zones and refugee camps, researchers are putting resilience interventions to the test 2018-02-28T05:00:00Z But with the economy now in good shape, there seems to be less inhibition. China is trying new ways of skimming housing-market froth 2018-02-15T05:00:00Z COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. MEK drives BRAF activation through allosteric control of KSR proteins 2018-02-11T05:00:00Z Theoharis implicitly urges students of the second reconstruction to review it anew, unbound by inherited inhibitions. Review | Has America created a misleading fable about the civil rights movement? 2018-02-02T05:00:00Z Will inhibitions start to creep in and diminish the improvisatory nature of street life here, putting a hitch in the strut of Mardi Gras revelers and second-line paraders? Will 1,500 Street Cameras Be a Wet Blanket in New Orleans? 2018-01-30T05:00:00Z The thrill, you soon understand, is the not knowing, and, of course, the inhibition of paralysis. Germany's greatest living composer has a moment under the L.A. Phil Green Umbrella 2018-01-24T05:00:00Z Patients with frontal-lobe dementias exhibit impaired insight and mental flexibility, poor judgment, impaired emotionality, lack of appropriate social inhibition with poor impulse control, and/or unpredictable changes in mood or affect. Opinion | ‘Excellent’ doesn’t seem like an accurate descriptor for Trump’s health 2018-01-19T05:00:00Z And yet when I look around at millennial women, problems with inhibition or the ability to hang on to a healthy sense of entitlement are not the ones I am quickest to identify. #MeToo and the Marketing of Female Narrative 2018-01-18T05:00:00Z We can barely imagine a person inhibited by his own appetites or impulses; the inhibition, rather, comes when those appetites can’t be fulfilled. Opinion | President Trump is the freest man alive 2018-01-18T05:00:00Z Look, we just drank ourselves into oblivion, it wasn’t great but it lowered inhibitions and never once involved hitting the laundry room, unless that’s where Dad kept the Beam. A beginner’s guide to eating Tide Pods, and other forms of laundry detergent - Golf Digest 2018-01-16T05:00:00Z Bars are where we go to drink alcohol, let our inhibitions down, and see what happens. Has #MeToo gone too far, or not far enough? The answer is both | Laura Kipnis 2018-01-13T05:00:00Z At the same time, the large amount of mumbling shows that there is still some motor inhibition at play; in other words, the brain is still blocking muscle movement. Some people curse and say nasty things in their sleep. There’s a good reason. 2018-01-05T05:00:00Z Symptoms of FTD include a lack of inhibition or social tact and unusual verbal, physical or sexual behavior. What if My Mother’s Extramarital Cravings Are Linked to Dementia? 2018-01-03T05:00:00Z The draft review concludes that sarin's chronic effects include AChE inhibition, vision and memory problems in people, as well as nerve pathology detailed in animal studies. Seeking answers for Iran’s chemical weapons victims—before time runs out 2018-01-04T05:00:00Z |
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