| 单词 | inactivation |
| 例句 | By happy coincidence, Paris was also home to the Pasteur Institute, and one of the main labs trying to solve the riddle of one of the most fundamental manifestations of epigenetics – X chromosome inactivation. Edith Heard: 'We can't undo what our parents have given us in terms of our genes' 2013-06-22T23:05:02Z “Our study is comprehensive in the sense that we’re not only worried about the inactivation of pathogens,” she said, adding that the researchers also focused on preserving the mask’s effectiveness. Researchers found a way to clean N95 masks for reuse — in a common electric cooker 2020-08-14T04:00:00Z When deployed in plants, Highlighter uses minimally invasive light signals for activation and inactivation, and is unaffected by the light-dark cycling in growth chambers. Conversations with plants: Can we provide plants with advance warning of impending dangers? 2023-09-21T04:00:00Z Because of X inactivation, aberrations in sex chromosomes typically have milder effects on an individual. Concepts of Biology 2013-04-25T00:00:00Z Because the gene that controls the expression of interferon gamma is on the X chromosome, it "escapes X inactivation in females" — meaning "there's more of it in females compared to males." Why do fewer women die of COVID? The answer may lie in the X chromosome's superpower 2023-03-22T04:00:00Z “Those guys obviously would help any team, but their inactivation was not the reason we lost this game,” McDaniel said. Injury-plagued Dolphins still alive despite latest setback 2023-01-01T05:00:00Z The team examined a range of temperatures and humidity levels to mimic typical storage conditions, measuring the rate of inactivation of the virus, and found: Infectious Covid virus can stay on some groceries for days 2022-12-01T05:00:00Z In part, this occurs because of a molecular process called X inactivation. Biology for AP Courses 2022-06-09T00:00:00Z The extra X chromosome undergoes inactivation to compensate for the excess genetic dosage. Concepts of Biology 2013-04-25T00:00:00Z When a cell is at rest, the activation gate is closed and the inactivation gate is open. Anatomy and Physiology 2013-06-19T00:00:00Z Given imperfections in the inactivation process, it would occasionally cause polio itself. Opinion | Why vaccinating kids for covid-19 makes sense — just like it did for polio 2021-11-11T05:00:00Z Biological dogma holds that women have two X chromosomes, but one copy is turned off in every cell very early in embryonic development in a process known as X inactivation. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z In all types, every X chromosome except one undergoes inactivation to compensate for the excess genetic dosage. Biology for AP Courses 2022-06-09T00:00:00Z In part, this occurs because of a process called X inactivation. Concepts of Biology 2013-04-25T00:00:00Z After that, the inactivation gate re-opens, making the channel ready to start the whole process over again. Anatomy and Physiology 2013-06-19T00:00:00Z In the future, Hall said the state may seek to exempt those 17-year-olds from inactivation when it writes administrative rules to implement the new law. Iowa moves 294,000 registered voters to ‘inactive’ status 2021-04-26T04:00:00Z But in recent years scientists have discovered that X inactivation does not happen the way they thought it did. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z Because of X inactivation, aberrations in sex chromosomes typically have milder phenotypic effects. Biology for AP Courses 2022-06-09T00:00:00Z In the future, Hall said the state may seek to exempt those 17-year-olds from inactivation when it writes administrative rules to implement the new law. Iowa moves 294,000 registered voters to ‘inactive’ status 2021-04-26T04:00:00Z This is because of the inactivation gate of the voltage-gated Na+ channel. Anatomy and Physiology 2013-06-19T00:00:00Z But research now shows that 15 percent of genes escape this inactivation and are more highly expressed in women. Women Report Worse Side Effects After a Covid Vaccine 2021-03-08T05:00:00Z Recently scientists uncovered something bizarre about X inactivation that also supports its role in autoimmunity. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z Carrier females can manifest mild forms of the trait due to the inactivation of the dominant allele located on one of the X chromosomes. Biology for AP Courses 2022-06-09T00:00:00Z It was easier and cheaper to manufacture because, unlike Salk's vaccine, inactivation of the virus by careful treatment with formaldehyde was not required. How a debate over two competing vaccines gripped the medical community — in 1961 2021-02-21T05:00:00Z The other gate is the inactivation gate, which closes after a specific period of time—on the order of a fraction of a millisecond. Anatomy and Physiology 2013-06-19T00:00:00Z There is some evidence, for example, that cumulative gene inactivation in the virus made it more virulent. Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z No one thought that females’ immune cells did anything different with regard to X inactivation than other cells did, but it turns out they do—in ways that could directly shape the risk for autoimmunity. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z Study authors calculated the expected inactivation by UVC and solar UV radiation in cities around the world at different times of the year. Summer rays can inactivate coronavirus in 34 minutes, study says 2020-06-23T04:00:00Z But as many as a quarter of X-linked genes can escape this inactivation, giving people with two copies of the chromosome a “double dosage” of the genetic instructions needed to fight disease. All across the United States, the coronavirus is killing more men than women, data show 2020-04-04T04:00:00Z Timed with the peak of depolarization, the inactivation gate closes. Anatomy and Physiology 2013-06-19T00:00:00Z Targeting these residues using chemical inactivation prevented neuronal tau uptake, highlighting their importance. A receptor that lets dementia-associated tau proteins into neurons 2020-03-31T04:00:00Z Perhaps, Wilson says, X-linked genes and incomplete X inactivation evolved as a way for a woman’s body to flexibly respond to the strange new immune requirements of pregnancy. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z During winter, most cities will not receive enough solar radiation to produce 90 percent viral inactivation during midday exposure, they wrote. Summer rays can inactivate coronavirus in 34 minutes, study says 2020-06-23T04:00:00Z If the inactivation process is effective, the next step is growing large quantities of the virus, so it can be inactivated and put into vaccines for testing. Inside the Colorado lab trying to develop a COVID-19 vaccine 2020-03-14T04:00:00Z Central tolerance is the destruction or inactivation of B cells that recognize self-antigens in the bone marrow, and its role is critical and well established. Anatomy and Physiology 2013-06-19T00:00:00Z Artificial stimulation or inactivation of these hippocampal areas enhances or diminishes an animal’s ability to recognize other animals. In Search of the Brain’s Social Road Maps 2020-01-14T05:00:00Z Cisgender women are mosaics: the random inactivation of one X chromosome in each cell means that half a woman’s cells express her mother’s X and half express her father’s. How science has shifted our sense of identity 2019-10-07T04:00:00Z The two authors conducted their calculations using a model for estimating solar inactivation of viruses of biodefense concerns, they said, adding that the methodolgy was validated with Ebola and Lassa viruses. Summer rays can inactivate coronavirus in 34 minutes, study says 2020-06-23T04:00:00Z Other examples of gut bacteria affecting drugs include the microbial inactivation of digoxin, which is used for heart conditions4, and the bacterial modification of the chemotherapeutic agent irinotecan, which causes toxic side effects5. Microbes make metabolic mischief by targeting drugs 2019-06-16T04:00:00Z The report says the inactivation memo does not include further details and that it is unclear whether any investigation took place. Sheriff’s Department killing more misconduct investigations under Villanueva, report finds 2019-04-12T04:00:00Z Mimicking two important aspects of cancer development, the inactivation of cancer suppressors and the acquisition of drug-resistance, we allowed the cells to choose how to evolve accelerated mutation rates. A New Idea about How Cancer Begins 2019-03-01T05:00:00Z Deciphering how its inactivation leads to resistance therefore seemed a daunting task. A new road to cancer-drug resistance 2018-10-30T04:00:00Z Borges and colleagues used a genetic approach to test whether the inactivation of bacterial defences was due to the presence of anti-CRISPR proteins from more than one phage in the same host cell. Viruses cooperate to defeat bacteria 2018-07-22T04:00:00Z Thus, the effects the scientists observed might be due to inactivation of these genes, not the reduction in LINE1 RNA. Don’t call it junk—This ‘jumping’ gene may be why you made it past an embryo 2018-06-21T04:00:00Z We assigned each cell to either of two cell populations distinguished by the parental X-chromosome designated for inactivation using genotype phasing. Landscape of X chromosome inactivation across human tissues : Nature : Nature Research 2017-10-10T04:00:00Z But by the 1990s, there were accounts of genes from outside these regions that also escaped inactivation. Genetics: Sex and the single cell : Nature : Nature Research 2017-10-03T04:00:00Z Most other AML-associated mutations in genes that encode epigenetic regulators cause protein inactivation, but mutations in IDH genes are an exception. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z PTO granted a patent that claims gene inactivation by the use of chimeric restriction endonucleases to the Pasteur Institute and Boston Children's Hospital. Dramatic twists could upend patent battle over CRISPR genome-editing method 2016-10-05T04:00:00Z The centers can use an available "donor screening test for Zika virus RNA" or an "approved or investigational pathogen inactivation technology," the agency said in a news release. Florida Reports First Locally Transmitted Zika Infections in U.S. 2016-07-29T04:00:00Z Following inactivation, samples were handled on the bench employing standard laboratory safety precautions. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z In their 2014 lung cancer study they also found that antioxidant supplements caused lung tumor cells to turn off the activity of a well-known cancer-suppressing gene called p53; its inactivation is believed to drive metastasis. Antioxidants May Make Cancer Worse 2015-10-07T04:00:00Z "The failure of inactivation was evident because growth was being detected on multiple production runs," he told the congressional hearing. U.S. Army lab faulted over lax anthrax procedure 2015-07-28T04:00:00Z The shipyard is also finishing up work on the inactivation of the USS Enterprise. Newport News Shipbuilding likely to cut 1,500 workers 2015-07-24T04:00:00Z Shipyard workers completed the inactivation of the former USS Miami, removing equipment and ship systems, before it was towed away by tugboats with assistance from two Navy ships, shipyard spokeswoman Danna Eddy said. Damaged nuclear submarine leaves shipyard, to be scrapped 2015-06-12T04:00:00Z It is one of the U.S. military labs responsible for inactivation and shipping of biological material. U.S. military lab shipped live anthrax samples to Canada: USA Today 2015-06-01T04:00:00Z "There is absolutely no excuse. Not for the shipping institution. Not for receiving institutions that failed to confirm inactivation upon receipt," he told USA Today. Health Highlights: May 29, 2015 2015-05-29T04:00:00Z Ebright said technicians failed to “inactivate a sample, followed by a failure to confirm inactivation before shipping the sample, followed by … a failure to confirm inactivation upon receiving the sample”. Pentagon anthrax blunder reveals 'chain of errors' in government lab protocols 2015-05-29T04:00:00Z “There is absolutely no excuse. Not for the shipping institution. Not for receiving institutions that failed to confirm inactivation upon receipt.” US military accidentally ships live anthrax to labs 2015-05-27T04:00:00Z The move follows a strict review late last summer of inactivation methods in each high-security lab. Exclusive: CDC installing cameras in labs in agency-wide safety push 2015-01-29T05:00:00Z It also prohibits inactivation of the aircraft carrier USS George Washington, a step being studied for budgetary reasons, and authorizes funding to begin an overhaul and refueling of the ship. Congress authorizes $577 billion in U.S. defense spending 2014-12-12T05:00:00Z And a team from the Wellcome Trust Sanger Institute in Hinxton, UK, reported that 43 genes whose inactivation is lethal to mice were found to be inactivated in humans who are alive and apparently well. Geneticists tap human knockouts 2014-10-27T04:00:00Z It monitors inactivation procedures for the 11 staff members working there. New Tracking Technologies Aim to Prevent Sloppy Handling at U.S. Biolabs 2014-09-15T04:00:00Z This is to be expected, as full inactivation of many of these genes would be lethal. Gibbon genome and the fast karyotype evolution of small apes : Nature : Nature Publishing Group 2014-09-09T04:00:00Z The procedure the scientists used inactivates B. anthracis cells after 10 minutes, but the researchers were dealing with spores, which are more resistant to chemical inactivation and so a small percentage remained viable. CDC Director Releases After-Anthrax Report And Orders More Reviews 2014-07-11T04:00:00Z This inactivation switch probably evolved to keep our immune systems from going haywire — overreacting and damaging organs. New therapies raise hope for a breakthrough in tackling cancer 2014-02-17T23:57:00Z Yet although epigenetic modifications are known to be important for processes such as development and the inactivation of one copy of the X-chromsome in females, their role in the inheritance of behaviour is still controversial. Fearful Memories Passed Down to Mouse Descendants 2013-12-01T23:45:00.493Z “It’s clear we need some way to secondarily verify that an inactivation is being done. This is one way to do that,” says Darin Carroll, acting chief of the Poxvirus and Rabies Branch at CDC. New Tracking Technologies Aim to Prevent Sloppy Handling at U.S. Biolabs 2014-09-15T04:00:00Z “Our experiments provide strong support that the sensory inactivation is principally due to the secretion physically covering the antennule and thus blocking chemicals from accessing chemosensory neurons,” the researchers conclude. Sea hares thwart spiny lobster attack with goo 2013-03-30T15:15:00.373Z It is clear from these experiments that the loss or permanent inactivation of genes does not necessarily accompany the normal differentiation of animal cells. Transplanted Nuclei and Cell Differentiation, by Sir John B. Gurdon 2012-10-09T23:45:00.177Z The model for recovery from inactivation by the L-peptide inadvertently read instead of . Erratum: Stereospecific binding of a disordered peptide segment mediates BK channel inactivation 2012-09-26T17:24:37.483Z MAP3K1, recently reported as mutated in oestrogen-receptor-positive breast cancers, harboured five mutations in three patients with oestrogen-receptor-positive disease, and followed a pattern consistent with positive selection for recessive inactivation of the gene. Sequence analysis of mutations and translocations across breast cancer subtypes 2012-06-20T17:22:32.787Z In two male patients this resulted in complete inactivation of the gene. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z This suggests that very few genetic lesions are required for retinoblastoma progression after inactivation. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z The goal of genome-guided analysis is to identify genes or molecules whose inactivation by one or more drugs will selectively kill parasites but not harm their host. Ascaris suum draft genome 2011-11-23T18:21:44.707Z In practice, however, we found that function in the canal is often diminished before surgery, and replacing the covering itself may lead to inactivation of the canal anyway. Medical Mystery: What Is Superior Canal Dehiscence Syndrome? 2011-09-01T11:15:00.200Z This is to our knowledge the first report of inactivation of this transcription factor complex in epithelial cancers. Sequence analysis of mutations and translocations across breast cancer subtypes 2012-06-20T17:22:32.787Z Over 1,000 people attended the "casing of the colors" ceremony where the flag of the unit was taken down and put into a protective covering, marking the unit's inactivation, according a spokesman. Casing of colors marks close of historic Walter Reed hospital 2011-07-27T20:43:55Z Tumours progress very quickly following inactivation but the underlying mechanism is not known. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z This is a way of dealing with the second cause of HIV inactivation. AIDS: No hiding place 2011-07-21T11:24:00Z The structure is consistent with the proposed mechanism of enzyme inactivation and provides a basis for the design of 5-LOX–specific inhibitors. This Week in Science 2011-01-13T19:25:00.650Z Making the protein inactivation temporary was also key. Removing a Barrier to Regrowing Organs 2010-08-10T14:48:00Z The 25th Division commander's charges were supported by the Eighth Army inspector general, who investigated the 24th Infantry at length but concluded that the inactivation of the 24th was unfeasible. Integration of the Armed Forces, 1940-1965 These data raise the possibility that inactivation may underlie the rapid acquisition of cooperating mutations in key cancer pathways through chromosome instability. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z The basis for the assumption that an isomerization constitutes the final and physiologically most significant step in the inactivation of a vitamine is found in the studies of synthetic antineuritic products. The Vitamine Manual The inactivation of some black units—"and the pronounced relief of the problems involved in maintaining those units under present conditions"—could be accomplished without injustice to Negroes and with benefit to the Air Force. Integration of the Armed Forces, 1940-1965 The first, inactivation of the 24th Infantry and the choice of a replacement, was quickly overcome. Integration of the Armed Forces, 1940-1965 When, for example, the reorganization of the Fleet Marine Force caused the inactivation of two black depot units, the division designated a 108-man truck company as a black unit to take up the slack. Integration of the Armed Forces, 1940-1965 |
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