| 单词 | haplotype |
| 例句 | The haplotype is found in about 16% of the population in Europe and half the population in South Asia, while in Africa and East Asia it is non-existent. Study: Neanderthal genes are a liability for COVID patients 2020-09-30T04:00:00Z Construction of the third generation Zea mays haplotype map. Dysregulation of expression correlates with rare-allele burden and fitness loss in maize 2018-03-13T04:00:00Z A general approach for haplotype phasing across the full spectrum of relatedness. Association analysis identifies 65 new breast cancer risk loci 2017-10-22T04:00:00Z The x axis shows the relative position to the centre of the two fragments within each haplotype. c, The Y-chromosome phylogeny is shown along with the number of structural variations for each main branch. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference : Nature : Nature Research 2017-07-25T04:00:00Z The triangles with the thin black outline represent haplotype blocks as computed by HaploView. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z The variant is not present on the other haplotype. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation. Dysregulation of expression correlates with rare-allele burden and fitness loss in maize 2018-03-13T04:00:00Z To analyse relationships among plastid sequences in plastid haplotype networks, a consensus sequence of the large single copy plastid region was extracted for each of the 38 samples. Genome sequence and genetic diversity of European ash trees : Nature : Nature Research 2016-12-25T05:00:00Z The x axis shows the relative position to the centre of the two fragments within each haplotype. c, The Y-chromosome phylogeny is shown along with the number of structural variations for each main branch. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference : Nature : Nature Research 2017-07-25T04:00:00Z The triangles with the thin black outline represent haplotype blocks as computed by HaploView. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z “I would be more comfortable if these therapies were implemented with haplotype matching.” UK moves closer to allowing ‘three-parent’ babies 2016-11-29T05:00:00Z Flowchart of the data generation, processing and analysing for the de novo assembly and haplotype phasing of the AK1 diploid genome. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z Clearest differentiation was found in the plastid network, with four distinct haplotype groups each separated from each other by at least 20 substitutions. Genome sequence and genetic diversity of European ash trees : Nature : Nature Research 2016-12-25T05:00:00Z Tracing a path through the graph corresponds to a particular haplotype; it is used as a stochastic automaton to sample such haplotypes that reflect the chosen edge probabilities. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference : Nature : Nature Research 2017-07-25T04:00:00Z The genotype calls were also imported into the genotype visualization software Flapjack97 to produce chromosome-scale images of haplotype diversity within the spring and winter pools. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z The advisory report suggests that haplotype matching should be considered “as a precautionary step in donor selection”, but does not recommend it be mandatory. UK moves closer to allowing ‘three-parent’ babies 2016-11-29T05:00:00Z Next, we investigated the haplotype structures associated with Asian-specific variants by using linkage disequilibrium blocks inferred from 1000 Genomes Project Asian samples10. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z This probably occurred in polymorphic regions of the genome where the haplotype in the fosmid did not match the haplotype in the reference. The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea : Nature : Nature Publishing Group 2016-01-26T05:00:00Z Consensus sequences were created for each parent–offspring haplotype using global alignment between all pairwise sets of phased variants. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference : Nature : Nature Research 2017-07-25T04:00:00Z Interestingly, we are unaware of any phenotypic trait in the winter gene pool that would result in strong selection for a single pericentromeric haplotype on chromosome 5H. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z For each subset of candidate SNPs we exhaustively generated all possible haplotype sequences by including/excluding the individual SNPs in the subset. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z Using the final set of phasing markers, subreads were classified into sets of haplotype A or B when >85% of the phasing markers agreed. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z To further classify regions with ‘double’ depth and single haplotype regions we implemented a Hidden Markov Model classifier. Hemichordate genomes and deuterostome origins : Nature : Nature Publishing Group 2015-11-17T05:00:00Z Then, for each haplotype, we compared the k-mers from that haplotype with the database and kept k-mers not found in the database. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference : Nature : Nature Research 2017-07-25T04:00:00Z Surprisingly, the two-row spring gene pool, generally considered to be narrowest owing to intense selection for malting quality, exhibited a greater number of haplotype blocks than the winter lines for most chromosomes. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z Metadata such as the total depth of the region and the number of reads that support the called haplotype over the reference sequence is also output. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z Flowchart of the data generation, processing and analysing for the de novo assembly and haplotype phasing of the AK1 diploid genome. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z This multi-stage approach allows the long-range structure of the haplotype scaffold to be maintained while including more complex types of variation. A global reference for human genetic variation : Nature : Nature Publishing Group 2015-09-29T04:00:00Z Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we constructed using short-read DNA sequencing data and statistically phased onto haplotype blocks in 26 human populations. An integrated map of structural variation in 2,504 human genomes : Nature : Nature Publishing Group 2015-09-29T04:00:00Z These results demonstrate the value of our expanded haplotype reference panel for discovery of trait associations driven by low-frequency and rare variants, as also shown in refs 9, 10. The UK10K project identifies rare variants in health and disease : Nature : Nature Publishing Group 2015-09-13T04:00:00Z For each subset of candidate SNPs, the haplotype with the largest likelihood is called as the sequence for the region. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z Linkage disequilibrium blocks with below 0.8 haplotype diversity index were excluded. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z The allelic complement of a cell is known as its haplotype. Epigenomics: Roadmap for regulation : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Association with IBD decreases with physical distance along the chromosome, due to rare recombination events that break up the haplotype and distinguish the causal missense mutation from other tightly linked neutral variants. Genetic and epigenetic fine mapping of causal autoimmune disease variants : Nature : Nature Publishing Group 2014-10-28T04:00:00Z The accuracy of haplotype predictions was validated by the concordance with SNPs residing in the same paired-end sequencing reads. Integrative analysis of haplotype-resolved epigenomes across human tissues : Nature : Nature Publishing Group 2015-02-17T05:00:00Z This suggests that, instead of large-scale population-specific sequencing across Africa, what is needed is a broad sequencing approach, targeted at capturing widespread haplotype diversity. The African Genome Variation Project shapes medical genetics in Africa : Nature : Nature Publishing Group 2014-12-02T05:00:00Z Despite the strong bias towards heterozygosity in these regions, a small proportion of either homozygous haplotype was always present, suggesting that there are genetic backgrounds in which homozygosity of any particular gene is not lethal. The genome of Eucalyptus grandis : Nature : Nature Publishing Group 2014-06-10T04:00:00Z Moreover, the specimen's B2 haplotype—a category of mitochondrial DNA—reveals that its mother was from the west coast of South America: Chile, that is. Bizarre 6-Inch Skeleton Shown to Be Human 2013-05-03T23:40:00Z For each haplotype, the seeds from four representative accessions were photographed. Draft genome of the wheat A-genome progenitor Triticum urartu 2013-04-04T15:21:00.373Z We attribute this pattern of eroded genetic diversity to low recombination in the pericentromeric regions, which reduces effective population size and consequently haplotype diversity. A physical, genetic and functional sequence assembly of the barley genome 2012-12-05T15:22:37.090Z Additionally, separation of mate-pair reads by haplotype may also help to detect expanded trinucleotide repeats in diseases such as Huntington’s disease, even though LFR does not provide direct length measure of these or similar repeats. Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells 2012-07-11T17:21:04.120Z The tree's root is marked by a haplotype called L3 that originated before humans left Africa; its genetic signature is found in many Africans and every non-African today. Human migrations: Eastern odyssey 2012-05-02T17:20:27.767Z They further noted that haplotype I is generally more prevalent in northern than in southern Europe, and that this distribution is paralleled by an increased risk of coronary artery disease in northern Europe. The Y Chromosome May Explain Why Men Have Earlier Coronary Disease 2012-02-09T18:21:18Z For each haplotype, the seeds from four representative accessions were photographed. Draft genome of the wheat A-genome progenitor Triticum urartu 2013-04-04T15:21:00.373Z He also requires that it be sorted by haplotype. The X Prize Foundation: Now count to a hundred 2011-10-26T18:33:02Z This implies that, at these QTLs, there is either a single functional variant, or a series of functional variants on the same haplotype. Mouse genomic variation and its effect on phenotypes and gene regulation 2011-09-14T17:21:52.063Z Coupled with abundant haplotype diversity, tetraploid potato may therefore contain thousands of -gene analogues. Genome sequence and analysis of the tuber crop potato 2011-07-13T17:21:42.673Z This information and the examination of allele combinations in the setting of haplotype analyses facilitate the translation of findings in nondiabetic populations to the newly diagnosed population. [Editors' Choice] Nature Versus Nurture in Newly Diagnosed Type 2 Diabetes 2011-01-06T15:27:53.087Z “Widespread occurrence of a domestic dog mitochondrial DNA haplotype in southeastern US coyotes.” Kissing Cousins 2010-05-12T01:00:00Z A haplotype is a group of genes that tend to travel through the generations as a block. The X Prize Foundation: Now count to a hundred 2011-10-26T18:33:02Z |
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