| 单词 | hair cell |
| 例句 | Using an extremely thin needle to deposit the bio-ink, the printer builds the skin layer by layer, while also creating channels for depositing the hair cells. Scientists 3D-print hair follicles in lab-grown skin 2023-11-15T05:00:00Z In collaboration with Professor Michael N. Hall's research group at the Biozentrum, Cortada investigated which signaling pathways influence the so-called sensory "hair cells" in the inner ear. New findings pave the way for hearing loss therapies 2023-10-05T04:00:00Z The inner hair cells are located at the termination of the "inner hair cell nerves" and the outer hair cells are located at the termination of the "outer hair cell nerves." Fundamentals of Biology 2015-01-01T00:00:00Z Maguire has sensorineural bilateral hearing loss, which stems from damaged hair cells within the inner ear and impacts his hearing. A deaf wrestler and self-described ‘nerd’ finds his identity on the mat 2023-01-11T05:00:00Z Most commonly, there is a loss of the tiny cochlear hair cells that convert sounds into an electrical signal. Newly available over-the-counter hearing aids offer many benefits — and drawbacks 2022-12-10T05:00:00Z Over time, the skin cells migrate to these channels surrounding the hair cells, mirroring the follicle structures present in real skin. Scientists 3D-print hair follicles in lab-grown skin 2023-11-15T05:00:00Z The role it plays for the hair cells in the inner ear has not previously been studied. New findings pave the way for hearing loss therapies 2023-10-05T04:00:00Z The hair cells in the organ of Corti are stimulated by particular frequencies of sound, based on their location within the cochlea. Fundamentals of Biology 2015-01-01T00:00:00Z Prolonged exposure to loud noise is one way we can permanently damage our cochlear hair cells and, consequently, our hearing. Hearing loss is a major risk factor for dementia. Hearing aids can help. 2022-10-20T04:00:00Z The electrodes stimulate the auditory nerve directly, bypassing the damaged hair cells. Newly available over-the-counter hearing aids offer many benefits — and drawbacks 2022-12-10T05:00:00Z When the growth of hair cells slows, the hair follicles become thin and break off. College Physics for AP Courses 2015-08-12T00:00:00Z When the researchers removed a central gene of this signaling pathway in the hair cells of the inner ear of mice, the animals gradually lost their hearing. New findings pave the way for hearing loss therapies 2023-10-05T04:00:00Z Lightly resting atop the longest cilia is the tectorial membrane, which moves back and forth with each cycle of sound, tilting the cilia and allowing electric current into the hair cell. Fundamentals of Biology 2015-01-01T00:00:00Z When these hair cells become degraded or die, the signals sent to the brain also become garbled. Hearing loss is a major risk factor for dementia. Hearing aids can help. 2022-10-20T04:00:00Z The inner hair cells are the primary auditory receptors and exist in a single row, numbering approximately 3,500. Biology for AP Courses 2022-06-09T00:00:00Z Therefore, as the frequency of a sound changes, different hair cells are activated all along the basilar membrane. Anatomy and Physiology 2013-06-19T00:00:00Z The team has even grown hair cells, sensory receptors that detect movement and enable hearing with tiny stalks called stereocilia sticking out of their surface. To learn how COVID affects the ear, scientists turn to cadavers 2022-01-17T05:00:00Z Stretching and compressing the tip links may open an ion channel and produce the receptor potential in the hair cell. Fundamentals of Biology 2015-01-01T00:00:00Z They studied how the SARS-CoV-2 virus interacts with inner ear cells like hair cells, nerve fibers, supporting cells and neuron insulators known as Schwann cells. COVID-19 can infect the ears — causing a chronic condition some call "Covid ear" 2021-11-19T05:00:00Z As a result, the hair cell membrane is depolarized, and a signal is transmitted to the chochlear nerve. Biology for AP Courses 2022-06-09T00:00:00Z Based on the animation, where do frequencies—from high to low pitches—cause activity in the hair cells within the cochlear duct? Anatomy and Physiology 2013-06-19T00:00:00Z Those eating plans may help in part by promoting blood flow to the inner ear’s cochlea, whose tiny hair cells transmit “messages” that the brain interprets as sound. Consistently eating the right foods can help your hearing, vision and teeth 2021-10-22T04:00:00Z The hair cells then stimulate the nerve cells in the Spiral Ganglion, which sends information through the auditory portion of the eighth cranial nerve to the brain. Fundamentals of Biology 2015-01-01T00:00:00Z But while the rest of the follicle dies, a collection of stem cells remains in the bulge, ready to start turning into hair cells to grow a new strand of hair. Losing Your Hair? You Might Blame the Great Stem Cell Escape. 2021-10-04T04:00:00Z The hair cells are arranged on the basilar membrane in an orderly way. Biology for AP Courses 2022-06-09T00:00:00Z When the stereocilia bend toward the tallest member of their array, tension in the protein tethers opens ion channels in the hair cell membrane. Anatomy and Physiology 2013-06-19T00:00:00Z It shows mechanosensory hair cells located in the inner ear that play a role in the sense of balance. The Beautiful Things inside Your Head: Winners of the 10th Annual Art of Neuroscience Contest 2020-07-23T04:00:00Z Immediately over the hair cells of the organ of Corti is an overhanging “tectorial membrane.” Fundamentals of Biology 2015-01-01T00:00:00Z Sensorineural hearing loss occurs as a result of damage to the inner ear organ, called the cochlea, which has intricate sound-sensing hair cells that are responsible for hearing. Beethoven’s dream 2019-11-03T04:00:00Z Likewise, the hair cells that lay above it are most sensitive to a specific frequency of sound waves. Biology for AP Courses 2022-06-09T00:00:00Z This will depolarize the hair cell membrane, triggering nerve impulses that travel down the afferent nerve fibers attached to the hair cells. Anatomy and Physiology 2013-06-19T00:00:00Z This sensory system, called the lateral line, uses delicate “hair cells” that are very similar to the ones found in our own ears. How a See-Through Fish Is Helping Answer Big Questions about Biology 2019-05-27T04:00:00Z These vibrations deflect the membrane on which the Organ of Corti is located, causing the three rows of outer hair cells to “rub” against the overhanging tectorial membrane. Fundamentals of Biology 2015-01-01T00:00:00Z In humans and other mammals, any damage to hair cells is irreversible. Beethoven’s dream 2019-11-03T04:00:00Z The difference in response frequency between adjacent inner hair cells is about 0.2 percent. Biology for AP Courses 2022-06-09T00:00:00Z When no sound is present, and the stereocilia are standing straight, a small amount of tension still exists on the tethers, keeping the membrane potential of the hair cell slightly depolarized. Anatomy and Physiology 2013-06-19T00:00:00Z “It answers a long-term question about how the hair cells in the inner ear actually work,” says David Corey, a neurobiologist at Harvard University and co-senior author of the new paper. A 40-Year Quest Uncovers Hearing's "Holy Grail" Protein 2018-08-29T04:00:00Z The disturbed inner hair cells will then activate the cochlear nerve fibers. Fundamentals of Biology 2015-01-01T00:00:00Z Other animals, such as birds, fish, amphibians and reptiles, can spontaneously regenerate their cochlear hair cells, meaning that any hearing loss they develop is only temporary. Beethoven’s dream 2019-11-03T04:00:00Z The basic pitch- determining mechanism is based on the location along the membrane where the hair cells are stimulated. Biology for AP Courses 2022-06-09T00:00:00Z Because the tectorial membrane only moves where the basilar membrane moves, the hair cells in this region will also only respond to sounds of this specific frequency. Anatomy and Physiology 2013-06-19T00:00:00Z Working with mice, the Harvard team showed the TMC1 gene encodes a protein that forms a hole in the hair cell membrane to allow ions to pass through. A 40-Year Quest Uncovers Hearing's "Holy Grail" Protein 2018-08-29T04:00:00Z Efferent synapses occur on outer hair cells and on afferent dendrites under inner hair cells. Fundamentals of Biology 2015-01-01T00:00:00Z Scientists have been studying the regeneration process of hair cells in non-mammals, and have identified various genes and proteins that have central roles. Beethoven’s dream 2019-11-03T04:00:00Z Outer hair cells connect to only 10 percent of the afferent neurons, and each afferent neuron innervates many hair cells. Biology for AP Courses 2022-06-09T00:00:00Z The ampulla contains the hair cells that respond to rotational movement, such as turning the head while saying “no.” Anatomy and Physiology 2013-06-19T00:00:00Z They then made targeted mutations in 17 different likely locations in the ears of neonatal mice to see if that changed the properties of the sensory hair cells. A 40-Year Quest Uncovers Hearing's "Holy Grail" Protein 2018-08-29T04:00:00Z That system operates as the body’s balance organ; its three semicircular canals are filled with fluid and tiny hair cells that sense in which direction the body is moving. What’s the Remedy for Car Sickness? 2018-08-15T04:00:00Z These can be targeted to stimulate support cells in the cochlea to in turn create more hair cells and replace those that died. Beethoven’s dream 2019-11-03T04:00:00Z It utilizes hair cells just like the auditory system, but it excites them in different ways. Biology for AP Courses 2022-06-09T00:00:00Z Figure 14.12 Rotational Coding by Semicircular Canals Rotational movement of the head is encoded by the hair cells in the base of the semicircular canals. Anatomy and Physiology 2013-06-19T00:00:00Z Other scientists are working on hair cell regeneration to treat acquired hearing loss using stem cells and other strategies. A 40-Year Quest Uncovers Hearing's "Holy Grail" Protein 2018-08-29T04:00:00Z The resulting swelling begins to damage the synapses linking surviving hair cells to auditory neurons. Ba-Boom! There Goes Your Hearing 2018-08-01T04:00:00Z Beethoven’s dream of regaining his hearing did not come true for him, but through the scientific advance of regeneration of hair cells, it could become a reality 217 years after his June walk. Beethoven’s dream 2019-11-03T04:00:00Z The base of each canal has a swelling that contains a cluster of hair cells. Biology for AP Courses 2022-06-09T00:00:00Z The organ of Corti, containing the mechanoreceptor hair cells, is adjacent to the scala tympani, where it sits atop the basilar membrane. Anatomy and Physiology 2013-06-19T00:00:00Z When acoustic energy reaches the inner ear, it bends the tiny bundles of hair cells that line the snail-shaped cochlea; that movement sends electrical impulses to the brain. A 40-Year Quest Uncovers Hearing's "Holy Grail" Protein 2018-08-29T04:00:00Z First, the shock wave overwhelms the tiny hair cells that line the snail-shaped cochlea. Ba-Boom! There Goes Your Hearing 2018-08-01T04:00:00Z Sensorineural hearing loss involves loss of hair cells and cochlear implants to bypass the damage by stimulating the neurons directly with electrodes. Light Beam Lets the Deaf (Gerbil) Hear 2018-07-16T04:00:00Z The utricle and saccule measure head orientation: their calcium carbonate crystals shift when the head is tilted, thereby activating hair cells. Biology for AP Courses 2022-06-09T00:00:00Z The stereocilia extend up from the hair cells to the overlying tectorial membrane, which is attached medially to the organ of Corti. Anatomy and Physiology 2013-06-19T00:00:00Z Each of the 16,000 hair cells that line the cochlea is a receptor that responds to a specific frequency. There's an "Inverse Piano" in Your Head 2018-06-04T04:00:00Z In the mouse model, the hair cells lose about half their connections to auditory nerve fibers, which means they cannot send proper signals for the brain to interpret as sounds. Ba-Boom! There Goes Your Hearing 2018-08-01T04:00:00Z The researchers independently investigated the role of hair cells in the inner ear. Million-dollar Kavli prize recognizes scientist scooped on CRISPR 2018-05-30T04:00:00Z The semicircular canals work similarly, such that when the head is turned, the fluid in the canals bends stereocilia on hair cells. Biology for AP Courses 2022-06-09T00:00:00Z Frequencies as low as 20 Hz are detected by hair cells at the apex, or tip, of the cochlea. Anatomy and Physiology 2013-06-19T00:00:00Z And those hair cells are in a systematic order, just as the piano strings are. There's an "Inverse Piano" in Your Head 2018-06-04T04:00:00Z In his mouse studies, Oghalai saw a chance to intervene in the window between the instant harm to hair cells and the delayed destruction of nerve synapses. Ba-Boom! There Goes Your Hearing 2018-08-01T04:00:00Z Merino sheep owe their curls to two types of hair cell. The cells that bestow those curly locks 2018-03-21T04:00:00Z Movement of stereocilia on hair cells results in an action potential that travels along the auditory nerve. Biology for AP Courses 2022-06-09T00:00:00Z Therefore, hair cells at the base of the cochlea are activated only by high frequencies, whereas those at the apex of the cochlea are activated only by low frequencies. Anatomy and Physiology 2013-06-19T00:00:00Z And another is the attempt to help regenerate hair cells. There's an "Inverse Piano" in Your Head 2018-06-04T04:00:00Z A lot more research is needed, but saving neural connections, even if some hair cells are lost, could potentially make a functional difference in hearing. Ba-Boom! There Goes Your Hearing 2018-08-01T04:00:00Z They wanted to count and measure individual hair cells, and human hair was too thick for that. Secrets to curly hair found in New Zealand sheep 2018-03-22T04:00:00Z Hearing loss resulting from absence or loss of hair cells in the organ of Corti. Biology for AP Courses 2022-06-09T00:00:00Z The macula is composed of hair cells surrounded by support cells. Anatomy and Physiology 2013-06-19T00:00:00Z One of the biggest challenges in the field is that hair cells in mammals are not replaced when they die. There's an "Inverse Piano" in Your Head 2018-06-04T04:00:00Z They rest on top of sensitive hair cells and shift gently as we move, giving feedback that lets us stay upright. Unlocking Secrets of Sour Flavors With Something Found in Your Ears 2018-02-03T05:00:00Z It consists of three semicircular canals containing fluid and sensory hair cells that pick up motion in the head. How Cheetahs Keep Their Heads Still While Sprinting 2018-02-05T05:00:00Z It is composed of hair cells held in place above the basilar membrane like flowers projecting up from soil, with their exposed short, hair-like stereocilia contacting or embedded in the tectorial membrane above them. Biology for AP Courses 2022-06-09T00:00:00Z The mice treated showed improved hair cell survival and hearing thresholds, and were startled by loud noises while untreated mice weren’t. Gene Editing Shows Promise for Alleviating Hearing Loss 2017-12-20T05:00:00Z One of the approaches we’re taking is to screen drugs to try to find a molecule that will allow hair cells to begin to regenerate again. There's an "Inverse Piano" in Your Head 2018-06-04T04:00:00Z These mutations cause the death of so-called hair cells in the inner ear, which convert mechanical vibrations like sound waves into nerve signals that the brain interprets as hearing. This gene therapy stopped mice from going deaf — and could save some humans’ hearing too 2017-12-20T05:00:00Z There the vibrations are transmitted to orderly arrays of “hair cells,” which are tuned to specific frequencies. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z The outer hair cells are arranged in three or four rows. Biology for AP Courses 2022-06-09T00:00:00Z Sound waves travel through the ear and wash over the hair cells of the inner ear, which bend under pressure and send an electrical impulse up the auditory nerve to the brain. Gene Editing Shows Promise for Alleviating Hearing Loss 2017-12-20T05:00:00Z Liberman’s work suggests that there’s another kind of damage that doesn’t kill off hair cells, but which leads to experiences like Garlock’s. Now hear this: Loud sound may pose more harm than we thought 2017-03-14T04:00:00Z The treatment allowed the hair cells to stay healthier and prevented the mice from going deaf. This gene therapy stopped mice from going deaf — and could save some humans’ hearing too 2017-12-20T05:00:00Z Recently, Edge and several other researchers succeeded in causing supporting cells they’d extracted from normal mice to divide and differentiate into large clusters of hair cells. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z The brain can send signals back to the cochlea, resulting in a change of length in the outer hair cells, sharpening or dampening the hair cells’ response to certain frequencies. Biology for AP Courses 2022-06-09T00:00:00Z Nearly half of all cases of deafness are due in some part to genetic factors, and many of those gene mutations affect the functioning of hair cells. Gene Editing Shows Promise for Alleviating Hearing Loss 2017-12-20T05:00:00Z It was a follow-up to Libermans’ earlier work that suggests loud noise damages the delicate connections between hair cells and the nerves that carry the hearing signal to the brain. Now hear this: Loud sound may pose more harm than we thought 2017-03-14T04:00:00Z The researchers developed a synthetic virus that was able to "infect" the ear with the correct instructions for building hair cells. Gene therapy: Deaf to hearing a whisper - BBC News 2017-02-06T05:00:00Z The image was an electron micrograph of a mouse hair cell, which measures about one-five-thousandth of an inch across and is structurally similar to a human one. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z About 90 percent of the afferent neurons carry information from inner hair cells, with each hair cell synapsing with 10 or so neurons. Biology for AP Courses 2022-06-09T00:00:00Z “It kickstarts supporting cells into becoming hair cells again,” says Lawrence Lustig, chair of otolaryngology at Columbia University Medical Center, one of three sites involved in the trial. Gene Editing Shows Promise for Alleviating Hearing Loss 2017-12-20T05:00:00Z New research suggests that the synapses connecting the hair cells to nerve fibers are even more vulnerable and suffer permanent damage long before the hair cells deteriorate, bringing about the difficulties in selective listening. Can’t Hear in Noisy Places? It’s a Real Medical Condition 2016-09-26T04:00:00Z The project is a consortium of scientists from across the country who have been collaborating for several years on the basic research needed to understand how to regenerate hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z Damage to hair cells or to the nerve synapses they’re attached to is the most common source of hearing loss. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z Both the auditory system and vestibular system use hair cells as their receptors. Biology for AP Courses 2022-06-09T00:00:00Z “But the ultimate is the death of the inner ear hair cells,” he says. Silent Side Effect: Could Your Medication Cause Hearing Loss? 2015-10-27T04:00:00Z The electrodes stimulate the hearing nerve, bypassing damaged hair cells and allowing the brain to perceive signals. Mankato hospital helps kids experience hearing 2015-08-31T04:00:00Z Each cluster of hair cells along the spiral is tuned to a different frequency of sound. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z It requires only functioning hair cells, Liberman said, and is unaffected by nerve damage until more than eighty per cent of the synapses are gone. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z Once in the cochlea, the energy causes the basilar membrane to flex, thereby bending the stereocilia on receptor hair cells. Biology for AP Courses 2022-06-09T00:00:00Z The device replicates the sense of hearing by electronically stimulating the cochlea to bypass the non-functioning hair cells of the inner ear, the hospital said. Walsall father has cochlear implant tattoo to support daughter - BBC News 2015-08-27T04:00:00Z Ear Genes Another strategy being tested in humans involves a gene that controls hair cell growth in the inner ear. Vertigo Knocks Millions off Their Feet, and Doctors Are Looking at Ear Implants to Relieve It 2015-07-30T04:00:00Z Accidents and illnesses, as well as some antibiotics and chemotherapy drugs, can destroy hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z “This is the chamber we use to deliver high levels of noise, to kill off hair cells,” she said. High-Tech Hope for the Hard of Hearing 2017-03-27T04:00:00Z The vestibular hair cells also send signals to the thalamus and to somatosensory cortex, but also to the cerebellum, the structure above the brainstem that plays a large role in timing and coordination of movement. Biology for AP Courses 2022-06-09T00:00:00Z Basically, a sound wave vibrates the eardrum and then passes to the cochlea, which contains rows of microscopic hair cells bathed in fluid. That ringing in your ears? Don’t assume it will just fade away. 2015-07-13T04:00:00Z This is a tiny arrangement, in each ear, of fluid-filled loops, bulbs and microscopic hair cells. Vertigo Knocks Millions off Their Feet, and Doctors Are Looking at Ear Implants to Relieve It 2015-07-30T04:00:00Z The fish have hair cells along the trunks of their bodies that sense movement of the water, a sign predators may be near. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The viral therapy alters most of the inner hair cells in the ear, but not the outer hair cells. Deafness could be treated by virus, say scientists - BBC News 2015-07-08T04:00:00Z Vitamin D synthesized from sunlight—available in abundance all summer—actually promotes the growth of hair cells. Does Your Hair Need Its Own Spa Treatment This Season? 2015-06-15T04:00:00Z These hair cells move with the sound and send signals through the auditory nerve to the brain, which interprets the sound. That ringing in your ears? Don’t assume it will just fade away. 2015-07-13T04:00:00Z In experiments on mice with severe inner ear damage, the compound restored hair cell levels to 50 percent of normal, with some improvement in hearing. Vertigo Knocks Millions off Their Feet, and Doctors Are Looking at Ear Implants to Relieve It 2015-07-30T04:00:00Z Once enough hair cells develop, the gene is switched off, never to become active again. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z It’s epigenetics that is responsible for ensuring that a hair cell becomes a hair cell and not a liver cell, and so on. Mom’s Pregnancy Diet Can Affect Child’s Lifetime Cancer Risk 2015-06-11T04:00:00Z Each hair cell contains a complete genome encased in a protective coating. Can scientists bring mammoths back to life? 2015-02-06T05:00:00Z Noise that’s too loud or long-lasting destroys the hair cells, causing hearing loss or partial deafness. That ringing in your ears? Don’t assume it will just fade away. 2015-07-13T04:00:00Z He is the first patient in a clinical trial of gene therapy aimed at regenerating hair cells. From Vertigo to Tinnitus, Ear Ailments Are New Focus for Drugs 2015-01-09T05:00:00Z Once inside, the genes order the supporting cells to start the process of growing into hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z Tinnitus is phantom ringing or other noise in the ear, a perception commonly caused by damaged hair cells in the cochlea. Misophonia is a newly identified condition for people hypersensitive to sound "That includes your hair cells, your nail cells, your white blood cells ... ." A baseball coach's son makes a dash for home 2014-10-02T04:00:00Z Once hair cells in the inner ear die, there’s no bringing them back to life. Hearing aids and other devices can counteract the hearing loss that many people experience Crucial to hearing are about 15,000 so-called hair cells in the cochlea, part of the inner ear, which convey signals to the auditory nerve leading to the brain. From Vertigo to Tinnitus, Ear Ailments Are New Focus for Drugs 2015-01-09T05:00:00Z The university clinical trial relies on a gene called Atoh1, which is known to cause hair cells to generate in mammals while they are still embryos in the womb. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z Native and engineered mechanosensory hair cells of the mammalian inner ear. [Review] Sound Strategies for Hearing Restoration 2014-05-08T18:26:15.183Z They amplify sound and carry it through the ear to the brain, but only if enough functioning hair cells in the cochlea can transmit the sound to the auditory nerve. Science Gave My Son the Gift of Sound 2014-04-25T15:25:03Z A month later, an otoacoustic emission test, which measures the response of hair cells in the inner ear, came back normal. A Son’s Deafness Prompts a Scientific Journey 2014-04-14T17:54:32Z And the hair cells do not regenerate, so once they are destroyed the loss is permanent. From Vertigo to Tinnitus, Ear Ailments Are New Focus for Drugs 2015-01-09T05:00:00Z “The idea is to kick-start the process that turns a supporting cell into a hair cell and then stop.” Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The human cochlea contains ~16,000 sensory hair cells that convert sound pressure into electrical signals. [Review] Sound Strategies for Hearing Restoration 2014-05-08T18:26:15.183Z Their disappearance severs the connection to the hair cells across the tiny gap, or synapse. Just 1 Rock Concert or Football Game May Cause Permanent Hearing Damage 2014-04-14T12:40:38Z Most hearing loss results from damage to the hair cells that help transmit sound waves through the snail-shaped cochlea in the inner ear to nerve cells the brain. Lasker Awards Go to Five Scientists and Gateses 2013-09-09T14:08:22Z Apparently the hair cells’ movement serves to localize and sharpen the frequency region of amplification. Turn It Up: The Ear May Have a Built-In Power Amplifier 2013-08-20T17:15:13.010Z But implanting those cells into the inner ear may be tricky, Fritzsch said, because there’s a fluid in the inner ear that’s toxic to all but the business end of the hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z Hudspeth uses a tuning fork and a 60-centimetre model of a hair bundle that shows audiences how hair cells in the ear move in response to sound waves and conduct signals to the brain. Presentations: Pressure to perform 2013-02-20T18:21:27.497Z The loss in auditory resolution doesn’t turn up on the traditional audiogram that measures the functioning of hair cells by determining whether they can detect a sound of a particular loudness and frequency. Just 1 Rock Concert or Football Game May Cause Permanent Hearing Damage 2014-04-14T12:40:38Z The best guesses for hair cell regeneration—for the much larger group of people whose sensorineural loss is caused by noise or ototoxins or age—range anywhere from twenty to fifty years. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z With hearing loss, this specificity is lost, and a much larger population of hair cells in the adjacent areas is “recruited” and also activated, producing sensitivity to noise. Q & A: Why, at 70, Is It Harder to Hear Conversations, yet Music Is Too Loud? 2013-02-04T20:04:12Z For example, some researchers have had success growing hair cells from stem cells in the laboratory. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z After three months researchers measured an estimated 20 percent increase in auditory hair cells by using a genetic color-coding system to track new growth. Hear-Raising: Compound Regenerates Auditory Hair Cells, Offering a Possible Treatment for Deafness 2013-01-12T12:45:00.197Z Liberman did seminal work in the 1980s on how noise kills hair cells. Just 1 Rock Concert or Football Game May Cause Permanent Hearing Damage 2014-04-14T12:40:38Z The 30,000 hair cells, arranged in four rows and protected by the hard shell of the cochlea, determine how well you can hear. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Normally, a specific sound frequency activates a specific population of hair cells located at a specific position within the cochlea. Q & A: Why, at 70, Is It Harder to Hear Conversations, yet Music Is Too Loud? 2013-02-04T20:04:12Z While other animals, such as fish and birds, can regrow hair cells from their support cells, humans and other mammals cannot. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z "Most of deafness is because of lost hair cells," says Elizabeth Olson, an auditory biophysicist at Columbia University. Hear-Raising: Compound Regenerates Auditory Hair Cells, Offering a Possible Treatment for Deafness 2013-01-12T12:45:00.197Z For older individuals, there was a significant loss of the nerve cells that carry an electrical representation of sound into the brain, whereas the hair cells remained intact. Just 1 Rock Concert or Football Game May Cause Permanent Hearing Damage 2014-04-14T12:40:38Z Surrounding the inner and outer hair cells are the so-called supporting cells, which come in all varieties: Deiters’ cells, Claudius’ cells, Hensen’s cells, inner pillar, and outer pillar cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z It changed the destiny of the cells, by altering which genes were being used in the cells, to transform them into hair cells. Grown hearing-hairs 'beat' deafness 2013-01-10T01:24:31Z Piotrowski and her colleagues have discovered a way that the fish’s genes signal its support cells to grow into hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The molecule works by allowing new hair cells to grow inside the inner ear. Hear-Raising: Compound Regenerates Auditory Hair Cells, Offering a Possible Treatment for Deafness 2013-01-12T12:45:00.197Z It was thought that only with the hair cells gone would your ability diminish to hear clearly through the busyness of the daily aural clamor. Just 1 Rock Concert or Football Game May Cause Permanent Hearing Damage 2014-04-14T12:40:38Z That limited number of hair cells, as well as their fragility and inaccessibility has hampered research. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z "There's been a lot of false starts - hair cell regeneration was originally demonstrated in the 1980s and everyone thought it would just be a matter of years." Grown hearing-hairs 'beat' deafness 2013-01-10T01:24:31Z These animals recovered about 50 to 70 percent of their hair cells, he said. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The direct application produced as much hair cell growth as the oral treatment, without significant side effects, the team reports. Drug Enables Deafened Mice to Hear Again 2013-01-09T20:10:00Z This is because the delicate hair cells that line the cochlea, the liquid-filled spiral cavity of the inner ear, are damaged. Dr. William F. House, Inventor of Cochlear Implant, Dies 2012-12-16T00:42:32Z Dr. Gates referred to him as the godfather of hair cell regeneration. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Most often the problem is the loss of sensory receptors in the inner ear known as hair cells, experts say. Question Mark: Why Does Hearing Decline in Baby Boomers? 2012-11-29T17:26:30Z The accident starved her of oxygen and obliterated the fragile microscopic hair cells of her inner ear that turn the motion of sound waves into nerve signals sent to the brain. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z When it comes to hearing, hair cells in the inner ear, so named for their bristlelike appearance, keep the process humming along, converting mechanical vibrations caused by sound waves into nerve impulses. Drug Enables Deafened Mice to Hear Again 2013-01-09T20:10:00Z His team then transplanted ONPs into the ears of gerbils that had been treated with ouabain, a chemical that damages auditory nerves, but not hair cells. Human Embryonic Stem Cells Restore Gerbil Hearing 2012-09-13T21:45:08.437Z Until 1985 it was thought that no animals could regenerate hair cells once they were destroyed. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Multiple types of cells formed, including precursor inner-ear hair cells, but they were also able to identify and isolate the cells beginning to differentiate into the desired spiral ganglion neurons. Stem Cells Turn Hearing Back On 2012-09-12T19:18:00Z For most, like James, it’s caused by the absence of inner-ear hair cells, an impairment called sensorineural hearing loss. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z He and his colleagues had previously found that a class of drugs called gamma-secretase inhibitors could prompt the growth of hair cells from inner ear stem cells growing in the lab. Drug Enables Deafened Mice to Hear Again 2013-01-09T20:10:00Z So far, though, when researchers remove the stem cells and culture them, the cells appear to “forget” they were ever hair cells. Treating Baldness is "Not Like Growing Grass" 2012-06-08T11:45:00.217Z Eleven years later the two labs are still collaborating on understanding how to prevent and cure hearing loss, and on hair cell regeneration. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z "The next big challenge will be to do something as effective as this for the hair cells," Maconochie adds. Stem Cells Turn Hearing Back On 2012-09-12T19:18:00Z But there has never been a way to actually restore hearing by regrowing the hair cells of the inner ear. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The lab also showed that the drugs worked by blocking the signaling of the Notch protein, which helps determine which cells become hair cells and which become support cells during ear development. Drug Enables Deafened Mice to Hear Again 2013-01-09T20:10:00Z The spiral-shaped organ of Corti, found in the cochlea, houses the sensitive hair cells that convert sound vibrations into nerve impulses. Inner Ear 2012-05-19T11:45:00.427Z In addition to hair cells in the inner ear, aquatic vertebrates like fish have hair cells on the outside of the body, in something called the lateral line. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z While birds and reptiles replace damaged hair cells, mammals normally do not. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z The injection James received contains a gene that researchers hope will promote the growth of new hair cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z The drug prompted supporting cells in the inner ear to become hair cells, and the treated mice regained some hearing, the group reports online today in Neuron. Drug Enables Deafened Mice to Hear Again 2013-01-09T20:10:00Z Her co-winner, Karen Steel of the Wellcome Trust Sanger Institute in Hinxton, UK, mapped key mouse genes involved in the function of cochlear hair cells, which pass sounds to the brain. Seven days: 9?15 March 2012 2012-03-14T18:20:17.293Z Stone led a recent study which found that after virtually all the vestibular hair cells in adult mice are killed, 16 percent of the hair cell population comes back spontaneously. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z The most common type of hearing loss, sensorineural, is the result of injury to the hair cells of the inner ear’s Organ of Corti, most commonly due to infections, medication, noise and aging. Empowering the Body to Fix Its Parts 2012-05-15T14:45:09.827Z “We don’t really clearly understand how many hair cells you need to get X number of decibels of hearing,” Staecker said. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z It's got hairs on the inside and this little dense calcium stone that sits on those hair cells. Eavesdropping on the squid world 2012-02-26T01:59:14Z In humans, sound waves traveling through the air hit the eardrum, causing the movement of tiny bones and vibrations of tiny hair cells in the inner ear. Vibrating Skulls Help Snakes Hear 2011-12-22T05:15:00Z Once we understand what allows the tissue to make new hair cells in these regions, Stone said, we can determine what would be needed to “release the brake,” as she put it. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Hearing aids are mostly used in people who suffer from hearing loss because of damage to hair cells, the small sensory cells in the inner ear. How long does it take for your brain to realize you have started to wear a hearing aid? 2011-01-04T16:15:42.337Z Some people have genetic conditions that keep their hair cells from ever developing. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z Habitual listening at those levels can turn microscopic hair cells in the inner ear into scar tissue, Fligor said. Study: 1 in 5 US teenagers has slight hearing loss 2010-08-17T22:36:00Z They tried various factors -- proteins and chemicals -- to nurture the cells and nudge them into becoming hair cells. Stem cells regrow crucial hearing cells in mice 2010-05-14T01:45:00Z To allow these hair cells to divide, the p27 gene would need to be turned off. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z GenVec is developing a technology to restore hearing or balance function through regeneration of sensory hair cells, specialized cells of the inner ear that help in hearing and balance. 2010-01-19T15:59:00Z The Hearing Restoration Project and other researchers have been looking at what genes are affected when hair cells are damaged for clues to how animals are able to regrow those cells. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z A third view is that the filaments from the hair cells, rather than the basilar membrane, respond to the vibrations and in turn stimulate the terminations of the nerve fibers. Physiology and Hygiene for Secondary Schools The bone cells and the hair cells, for instance, can hardly be so much alive—or so irritable—as the muscle cells; nor these as intensely alive as the nerve and brain cells. The Breath of Life Cochlear implants cause the destruction of the so-called support cells that might give rise to new hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z The auditory nerve terminates in eight sense organs, which contain hair cells. Harvard Psychological Studies, Volume 1 Containing Sixteen Experimental Investigations from the Harvard Psychological Laboratory. From such discoveries may come insights into what drugs might spur human support cells to become hair cells, Barr-Gillespie said. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z It is covered with a layer of epithelial cells, some of which have small, hair-like projections and are known as the hair cells. Physiology and Hygiene for Secondary Schools How can supporting cells be coaxed into making more hair cells? Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z But, as Jenny Stone said, the same question could be asked about regenerated hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Her mice produced extra hair cells and showed some precocious cell division in the cochlea. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z When scientists discovered that birds can regenerate their hair cells, some were predicting human therapies within five years. Kansas research holds hope for hearing restoration 2015-12-11T05:00:00Z By the time the mice were three days old, the increase in hair cells had dropped to 30 percent. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z That Heller and his lab were able to produce sensory hair cells in mice using both these kinds of stem cells is significant. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z How is it that mammals got shortchanged in the hair cell regeneration department? Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Before they can be used to regenerate hair cells, these stem cells will have to be rendered non-tumorigenic. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z These cells are not from the ear, so making the claim that these are hair cells is a difficult one. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z They look like hair cells, they express genes that one would expect to find in hair cells, and they are functional, and moreover, we are approaching the point where we can generate human hair cells.” Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z He pointed out that they already know some genes and some compounds that facilitate the production of new hair cells in some conditions, but they don’t have the lead compound. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z The hair cells of a bird are “scattered in a mosaic all over the surface of the hearing organ,” Andy Groves told the Hearing Restoration conference. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z One further problem is ensuring that the hair cells grow where they are supposed to. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z The purpose of his research was to determine how long it took for ototoxic drugs to damage hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Studying the cochlea of chicks and other birds, Rubel and others found eventually—over eighteen years!—that bird hair cells do indeed regenerate. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Then, after a few days, a high-power scanning electron microscope showed that all the hair cells were back. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Mammals, by contrast, have decreased the number of hair cells and specialized the function of the supporting cells surrounding them. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z It turns out that fish and reptiles, like birds, regenerate hair cells, as do frogs and other animals. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z They tested drugs and druglike compounds to find ones that inhibit hair cell death in the fish. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z This work may lead to the development of protective cocktails to preserve hair cells before exposure to antibiotics or ototoxic chemotherapy drugs. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Almost twenty years ago, it was proposed that hair cells and support cells, side by side, participate in an ongoing conversation using an evolutionarily ancient communication system called the Notch signaling pathway. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Supporting cells physically position hair cells, Groves explained, and they provide structural integrity to the cochlea to make it mechanically sensitive. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z The hair cell commands the support cell not to divide and prevents it from becoming a hair cell. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z When they blocked the signaling in newborn mice, they saw a 50 percent increase in hair cells and fewer supporting cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Stefan Heller and his colleagues are taking a different approach to regenerating hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z They do this in a culture dish and in a laboratory setting, which allows them to learn a lot about the process, such as what it actually takes to make sensory hair cells from scratch. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Groves speculates that mammals made a trade-off: in the course of developing high-frequency hearing, their hair cells became more specialized, and in the process they lost the ability to regenerate. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Further, that they were “mechanosensitive” means that they were responsive to mechanical stimulation, and that these responses were similar to those in immature hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z “We are basically making hair cells from human skin cells,” he said. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z But they do have all the features of hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Just as a mouse embryo takes only three weeks to develop, compared to a human’s nine months, the mouse embryonic stem cells take eighteen to twenty days to become hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z As a result, mammals would not suffer a selective disadvantage by losing the capacity to regenerate their hair cells. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z I think with proper funding, we can, in ten years, develop ways to get sufficient numbers of hair cells in a laboratory mammal cochlea as a model. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z |
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