| 单词 | haemophilia |
| 例句 | Rasputin was brought in to help with the care of the Russian heir to the throne, Alexei, who secretly suffered from haemophilia. Leonardo DiCaprio set to play Rasputin 2013-06-10T11:59:49Z When her infant son is diagnosed with haemophilia, she turns to Rasputin and the power of prayer. Nicholas and Alexandra: mashing up history can't make this pair lovable 2013-06-14T09:04:00Z This career was interrupted by the second world war, during which Freeborn trained as a fighter pilot before being diagnosed with Asian flu and haemophilia. Stuart Freeborn 2013-02-08T14:14:35Z "So diabetes, obesity, cardiovascular disease, the whole cardiometabolic space, but also in the rare blood disorders, haemophilia, sickle cell, we believe that we have a stronghold there," he said in an interview. Drugmaker Novo Nordisk seeks obesity, diabetes 'bolt-on' deals 2023-11-10T05:00:00Z He died as a result of receiving contaminated blood products, having been infected with hepatitis C and HIV as a child, while receiving treatment for haemophilia. Infected Blood Inquiry: Rishi Sunak to give evidence 2023-07-25T04:00:00Z As a result of his campaigning, along with Ms Bey, a joint haemophilia and sickle clinic finally opened in their town, the first in Taita Taveta county. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z A total of 1,250 people with haemophilia and other bleeding disorders contracted HIV after being given a protein made from blood plasma known as Factor VIII. Infected blood scandal: Five facts we have learned 2023-02-02T05:00:00Z In what has been called the worst treatment disaster in the history of the NHS, one group infected was given regular injections of a contaminated treatment for the blood-clotting disorder, haemophilia. No timetable for infected blood victims' compensation 2022-12-15T05:00:00Z Clinical trial data suggest that the single dose of Hemgenix will provide people with moderate to severe haemophilia with adequate protection from uncontrolled bleeding for eight years, and potentially longer. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z About 380 children with haemophilia and other blood disorders are now thought to have tested positive for the virus. 1 in 3 infected with HIV in blood scandal was a child 2022-11-09T05:00:00Z More than 150 children with the blood disorder haemophilia were infected with HIV in the 1980s, according to documents from the national archives seen by BBC News. HIV: How 175 British children were infected with disease 2022-10-05T04:00:00Z In what has been called the worst treatment disaster in the history of the NHS, one group infected was given regular injections of a contaminated treatment for blood-clotting disorder haemophilia in the 1970s and 1980s. Infected blood transfusions probably killed 1,800 in UK - study 2022-09-17T04:00:00Z "The growth will be fuelled again by very strong assets coming up," said de Chatillon, pointing to a haemophilia drug project and potential new treatment for childhood respiratory infections. Analysis: Meagre medicine cabinet leaves Sanofi unloved 2022-08-22T04:00:00Z “Living with haemophilia is all about where one is born,” says Glenn Pierce, vice-president of the World Federation of Hemophilia in Montreal, Canada. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z He was one of more than 120 pupils with haemophilia at Treloar College, a specialist boarding school in Hampshire, in the 1970s and 80s. 1 in 3 infected with HIV in blood scandal was a child 2022-11-09T05:00:00Z As a toddler, he had been diagnosed with haemophilia, a genetic disorder that stopped his blood clotting properly. HIV: How 175 British children were infected with disease 2022-10-05T04:00:00Z As a young boy in the 1970s Myles Hutchison was treated at Edinburgh Royal Infirmary for haemophilia, with blood products that he later discovered were contaminated. Contaminated blood: If I was paid in tears I'd be a billionaire 2022-08-17T04:00:00Z The inquiry has looked at how NHS patients with haemophilia and other blood disorders became seriously ill after being given a new treatment imported from the US. Infected blood scandal victims in line to get £100,000 2022-08-07T04:00:00Z But scientists worry that the price would not be affordable in low- and middle-income countries, where most people with haemophilia live and where supplies of treatments and factor IX are often insufficient. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z In the 1970s and 1980s, about 3,000 people in Scotland contracted Hepatitis C and HIV through blood products used to treat conditions like haemophilia. Donald Dewar feared 'open chequebook' over blood scandal 2022-07-26T04:00:00Z That included 175 children given the medication by NHS doctors in hospitals, schools or haemophilia clinics. HIV: How 175 British children were infected with disease 2022-10-05T04:00:00Z A "transformational" therapy has effectively cured people with the bleeding disorder haemophilia B, say British doctors. Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z People with haemophilia, including many young children, were infected, along with others who were given treatment. Sir John Major calls contaminated blood scandal 'incredibly bad luck' 2022-06-27T04:00:00Z Tuddenham and his colleagues showed in an eight-year follow-up study of a clinical trial of a similar drug for haemophilia B that there are good reasons to consider gene therapies a stable and durable treatment. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z In fact, he says he was deemed medically unfit and rejected from the Canadian Armed Forces three years ago due to haemophilia. Ukraine crisis: The comic travelling 5,000 miles to fight 2022-02-28T05:00:00Z By May 1983, the first suspected cases of HIV in British haemophilia patients were reported in Bristol and Cardiff. Blood inquiry: Former cabinet minister says Aids advice was "regrettable" 2021-09-22T04:00:00Z But he managed to stay healthy, unlike many others with haemophilia who face severe damage to their joints from the bleeding. Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z That same year the US published its first bulletin linking haemophilia treatment with HIV. Blood inquiry: Former health minister defends blood products advice on Aids 2021-07-28T04:00:00Z The FDA’s approval highlights difficulties in the quest to develop gene therapies for haemophilia more generally. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z Lord Clarke was a Conservative health minister in the early 1980s when up to 30,000 people with haemophilia and other bleeding disorders were given contaminated blood products. Contaminated blood inquiry: Former health minister Clarke to give evidence 2021-07-26T04:00:00Z In 1982 the US published its first bulletin linking haemophilia treatment with what would become known as Aids. Infected blood: Parents and pupils reveal they were kept in dark at stricken school 2021-06-25T04:00:00Z The medical team says the majority of adults with haemophilia could be cured in the next three years. Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z In May 1983, the first suspected infections of British haemophilia patients were reported in Bristol and Cardiff. Blood inquiry: Former health minister defends blood products advice on Aids 2021-07-28T04:00:00Z Only 15% of people with haemophilia have haemophilia B. Most have haemophilia A—a genetic disorder caused by a deficiency in a different blood-clotting protein called factor VIII, which is encoded by a different gene. $3.5-Million Hemophilia Gene Therapy Is World’s Most Expensive Drug 2022-12-09T05:00:00Z He was diagnosed with haemophilia aged three when he broke his leg, the inquiry heard. Infected blood inquiry: Diagnosed with HIV at 15 then 'left to go and die' 2021-06-23T04:00:00Z Lee was born with severe haemophilia, a rare condition in which the blood does not clot properly. Infected blood: Parents and pupils reveal they were kept in dark at stricken school 2021-06-25T04:00:00Z "My life is completely normal, there's nothing that I have to stop and think 'how might my haemophilia affect this?'." Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z The haemophilia centre on the site was run by NHS doctors and nurses and not staff directly employed by the school, which still cares for physically disabled children today. Contaminated blood inquiry: The school where dozens of pupils died 2021-06-20T04:00:00Z Nearly 5,000 people with the blood disorder haemophilia were infected with potentially fatal viruses after being given a clotting agent called Factor VIII. Contaminated blood inquiry: Matt Hancock to give evidence 2021-05-20T04:00:00Z The witness, who received treatment for his haemophilia, a blood condition which affects the clotting of blood, at the college, said he was about 15 when he was given the diagnosis. Infected blood inquiry: Diagnosed with HIV at 15 then 'left to go and die' 2021-06-23T04:00:00Z Lord Mayor Treloar College was the only site like it in the country with its own haemophilia centre, run by a small group of NHS doctors. Infected blood: Parents and pupils reveal they were kept in dark at stricken school 2021-06-25T04:00:00Z She says there was a "transformational impact" about a year after the therapy, when suddenly people realised: "I don't need to worry about my haemophilia at all." Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z Lord Mayor's Treloar's College was a boarding school for physically disabled children with a specialist NHS haemophilia centre on site, run by a dedicated medical team. Contaminated blood inquiry: The school where dozens of pupils died 2021-06-20T04:00:00Z The infections happened when people with haemophilia and other bleeding disorders were given a clotting agent called Factor VIII, introduced to help them recover more speedily from injuries. NHS blood infection scandal payments to increase 2021-03-25T04:00:00Z Most of those involved had the blood-clotting disorder haemophilia and relied on regular injections of Factor VIII. Scotland 'could have helped hundreds avoid HIV' 2020-01-02T05:00:00Z This engineered RNA approach is also being applied to a new RNAi therapeutic for haemophilia — a disease characterized by the lack of clotting agents in the blood. The challenge of delivering RNA-interference therapeutics to their target cells 2019-10-15T04:00:00Z This trial is just the latest in a series of breakthroughs in treating both haemophilia A and B. Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z By the mid 1970s, a new treatment for haemophilia, known as factor VIII/IX, became available for the first time. Contaminated blood inquiry: The school where dozens of pupils died 2021-06-20T04:00:00Z Like other people with haemophilia A, he will need life-long treatment. New drug for people who can bleed uncontrollably 2019-08-20T04:00:00Z People with haemophilia and other bleeding disorders were given blood infected with HIV and hepatitis viruses, during the 1970s and 80s. More witnesses prolong NHS blood scandal inquiry 2019-07-26T04:00:00Z A haemophilia centre at the University Hospital of Wales was named after Prof Bloom who died in 1992 aged 62. Manslaughter claim against haemophilia doctor 2019-07-25T04:00:00Z Prof Chowdary told me she's now "looking for my next job", as curing haemophilia "will be a reality for the majority of the adults in the next one to three years." Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z After enduring years of medication for haemophilia, HIV and hepatitis, his heart failed and a week after the surgery, he died on Christmas Eve, aged 44. 'Doctors knew my son had HIV, but didn't tell him' 2019-07-24T04:00:00Z People with haemophilia and other bleeding disorders were given blood infected with HIV and hepatitis viruses during the 1970s and 1980s. Infected blood inquiry to hear from Scots victims 2019-07-01T04:00:00Z People with haemophilia and other bleeding disorders were given blood infected with HIV and hepatitis viruses, during the 1970s and 1980s. Why did the NHS give thousands contaminated blood? 2019-06-13T04:00:00Z Some 4,800 people with haemophilia were infected with Hepatitis C over two decades. Blood scandal man saw four brothers die 2019-06-11T04:00:00Z By the late 1990s, synthetic treatments for haemophilia became available, removing the infection risk. Blood compensation 'matter for assembly' 2019-05-23T04:00:00Z When a five-year-old Paul Summers was diagnosed with the blood disorder haemophilia in 1969, his parents Pat and Tony were shocked, but also relieved. 'Doctors knew my son had HIV, but didn't tell him' 2019-07-24T04:00:00Z By the late 1990s, synthetic treatments for haemophilia became available, removing the risk of infection. Infected blood inquiry to hear from Scots victims 2019-07-01T04:00:00Z He was one of 89 boys at the school with haemophilia, who were offered treatment onsite. Blood scandal teens' pact to reveal killer 2019-05-01T04:00:00Z Mr Cornes, who started to receive treatment for haemophilia from 1979 onwards, said that as children "the only treatment was transfusions with ice cold packs to stop the bleeding". Blood scandal man saw four brothers die 2019-06-11T04:00:00Z And by the late 1990s, synthetic treatments for haemophilia became available, removing the infection risk. Blood inquiry evidence 'harrowing and chilling' 2019-04-30T04:00:00Z Retired teacher Pat and former businessman Tony look back with pride at their son's drive, stoicism and "wicked sense of humour" in the face of his haemophilia. 'Doctors knew my son had HIV, but didn't tell him' 2019-07-24T04:00:00Z The FDA, for example, offered its first draft recommendations by class of illness, starting with haemophilia, retinal disorders and rare diseases. Regulating the gene-therapy revolution 2018-12-11T05:00:00Z One vector used in the haemophilia work yielded only a temporary cure; another produced more lasting results but led to an increased risk of liver tumours. Prenatal gene therapy offers the earliest possible cure 2018-12-11T05:00:00Z James is a haemophilia patient and was curious about what happened to his blood after it was taken by doctors. Boy gets wish and trades place with doctor 2018-11-20T05:00:00Z Plasma also contains clotting factors that can be used to help treat haemophilia, and albumin, a protein that can be used to help heal burns. Should we pay people for donating blood or not? 2018-11-14T05:00:00Z Screening of blood products began in 1991 and by the late 1990s, synthetic treatments for haemophilia became available, removing the infection risk. Infected blood victims 'on the breadline' 2018-10-17T04:00:00Z It would be a leader in gastroenterology, neuroscience, oncology, rare diseases and blood-derived therapies used for serious conditions such as haemophilia. Takeda's $62 billion Shire bid faces November 6 EU antitrust deadline 2018-09-28T04:00:00Z More importantly, the development of postnatal gene therapy for haemophilia had taken a sudden leap forward. Prenatal gene therapy offers the earliest possible cure 2018-12-11T05:00:00Z It will look at how NHS patients, many with the inherited bleeding disorder haemophilia, came to be given blood products infected with hepatitis and HIV during the 1970s and 1980s. In a hurry? Here's what you need to know this morning 2018-09-24T04:00:00Z Screening of blood prodcuts began in 1991 and by the late 1990s, synthetic treatments for haemophilia became available, removing the infection risk. Blood scandal inquiry 'must uncover truth' 2018-09-23T04:00:00Z Almost 5,000 people with the blood disorder haemophilia were given a treatment contaminated with hepatitis and in many cases HIV. 'I gave birth, and got Hepatitis C' 2018-09-20T04:00:00Z “It’s no more only about shortages in drugs for cancer or special diseases such as haemophilia or thalassemia, but also normal drugs that were abundant in Iran previously,” she said. 'A matter of life and death': Iranians despair as US sanctions bite 2018-08-07T04:00:00Z Many people with a severe form of haemophilia A develop antibodies against factor VIII, which makes replacement therapy more costly and complicated, says Almeida-Porada. Prenatal gene therapy offers the earliest possible cure 2018-12-11T05:00:00Z Chan and others have previously tested fetal gene therapy to treat haemophilia in mice and macaques, and Chan expects that there will be interest in doing so for several metabolic diseases similar to Gaucher's. Gene therapy in mouse fetuses treats deadly disease 2018-07-15T04:00:00Z About 5,000 people with haemophilia and other bleeding disorders were infected with HIV and hepatitis viruses over a period of more than 20 years. Blood scandal inquiry 'must uncover truth' 2018-09-23T04:00:00Z But estimates range from about 5,000 - the same number of people with haemophilia affected - to up to 28,000, the figure suggested by a Department of Health analysis of the scandal. 'I gave birth, and got Hepatitis C' 2018-09-20T04:00:00Z Further ahead, a new generation of cures, such as a gene therapy for haemophilia, may cost more than $1m. Americans, tired of high-priced drugs, are fighting back 2018-05-10T04:00:00Z Other researchers argue that haemophilia remains a good prenatal target. Prenatal gene therapy offers the earliest possible cure 2018-12-11T05:00:00Z One entry refers to Alexei's haemophilia, the genetic blood disorder that was passed on to several members of Europe's royal families via two of Queen Victoria's daughters. The tutor who witnessed the downfall of the last tsar 2018-03-12T04:00:00Z Incurable diseases from sickle cell to haemophilia now look as though they can be treated. Breakthroughs put diseases on the back foot 2017-12-23T05:00:00Z Thousands of NHS patients with an inherited bleeding disorder called haemophilia were given the plasma products, which came from abroad, including the US. Contaminated blood report 'full of lies' 2017-12-19T05:00:00Z British doctors say they have achieved "mind-blowing" results in an attempt to rid people of haemophilia A. Haemophilia trial's 'mind-blowing' result 2017-12-13T05:00:00Z As an adult, he had to take holidays only in countries with excellent haemophilia centres, just in case. Leap forward towards gene therapy cure for haemophilia A 2017-12-13T05:00:00Z In the late 1970s and early 1980s, about half of all people with haemophilia in the United States became infected with HIV. Screening: In the blood : Nature : Nature Research 2017-09-26T04:00:00Z Doctors say they have achieved "mind-blowing" results in an attempt to rid people of haemophilia A. Breakthroughs put diseases on the back foot 2017-12-23T05:00:00Z After decades of frustrations, firms believe there are now major opportunities for gene therapy in treating inherited conditions such as haemophilia. Gene Therapy Is Now Available, but Who Will Pay for It? 2017-08-08T04:00:00Z Of the 13 patients given higher doses, all are off their haemophilia medication a year on and 11 are producing near-normal levels of factor VIII. Haemophilia trial's 'mind-blowing' result 2017-12-13T05:00:00Z “It means I don’t have haemophilia any more. It’s crazy,” he said. Leap forward towards gene therapy cure for haemophilia A 2017-12-13T05:00:00Z Many were patients with the inherited bleeding disorder haemophilia. Lessons must be learned in tainted blood inquiry, say campaigners - BBC News 2017-07-13T04:00:00Z Colin was born with haemophilia - but it was the treatment he was given that killed him. Blood scandal: Families search for the truth - BBC News 2017-05-09T04:00:00Z Thousands of people with haemophilia were infected with HIV and hepatitis as a result of NHS treatments in the 1970s and 80s. 'Blood contamination tore my family apart' - BBC News 2017-04-10T04:00:00Z “The successes in haemophilia are pretty remarkable, although it remains to be seen how enduring these treatments are,” says Glorioso, who was not involved in the trials. Gene therapy: Industrial strength : Nature : Nature Research 2016-09-06T04:00:00Z Scientists believe they are on the way to finding a cure for haemophilia A, the bleeding disorder that currently requires sufferers to inject themselves every other day to avoid life-threatening complications. Leap forward towards gene therapy cure for haemophilia A 2017-12-13T05:00:00Z One, made by Pfizer, a giant drugmaker, and Spark Therapeutics, a biotech company, is for haemophilia B, a rare bleeding disorder. Fixing fate 2016-07-28T04:00:00Z These deals may work for some conditions, such as haemophilia B, for which several drugs might be approved. Promising gene therapies pose million-dollar conundrum 2016-06-14T04:00:00Z Platelets are needed after trauma, surgery, leukaemia therapy and in some blood disorders like haemophilia. Huge leap to mass produced platelets - BBC News 2016-04-08T04:00:00Z High costs may raise huge concerns but they will not necessarily stop people paying, even for diseases such as haemophilia where other treatments are available. Gene therapy: Industrial strength : Nature : Nature Research 2016-09-06T04:00:00Z Scientists always thought it ought to be possible to find a gene therapy for haemophilia, but it has taken many years of unsuccessful attempts. Leap forward towards gene therapy cure for haemophilia A 2017-12-13T05:00:00Z Nick Meade, from Rare Disease UK, says the illnesses are clarified as those affecting fewer than one in 2,000 people - cystic fibrosis and haemophilia are included in this definition. The children living with the world's rarest diseases - BBC News 2016-02-28T05:00:00Z Gene therapies that are close to US approval include treatments for haemophilia B, sickle-cell anaemia and the neurodegenerative disease cerebral adrenoleukodystrophy. Promising gene therapies pose million-dollar conundrum 2016-06-14T04:00:00Z This reflects the promise the technology offers for producing treatments, and even cures, for a wide range of conditions—and not just those linked to mutated genes, such as haemophilia or sickle-cell anaemia. Cutting remarks 2016-01-07T05:00:00Z If these preliminary results are sustained and repeated across large numbers of patients, gene therapy may offer a single-shot 'cure' for many people with haemophilia. Gene therapy: Industrial strength : Nature : Nature Research 2016-09-06T04:00:00Z She hails the trial and a second study into gene therapy for people with a resistant form of the rarer haemophilia B as “leading the way to a cure for haemophilia”. Leap forward towards gene therapy cure for haemophilia A 2017-12-13T05:00:00Z Trials of gene editing to treat leukaemia, HIV and haemophilia are planned or under way in the United States and the United Kingdom. Global summit reveals divergent views on human gene editing 2015-12-07T05:00:00Z The health ministry scrambled for currency, but within months the shortage of medicine was critical for millions of Iranians suffering from multiple sclerosis, hepatitis, haemophilia, cancer, diabetes and thalassemia. Iran under sanctions: no money for medicine but luxury cars aplenty 2015-08-26T04:00:00Z "The obvious gap in Shire’s strategy is the risk of transformative change in the haemophilia market," Bernstein analysts said in a note. Shire seen having to sweeten $30 billion offer to win Baxalta 2015-08-05T04:00:00Z Remains believed to be those of Nicholas II’s heir, Alexei, who suffered from haemophilia, and his sister Maria, lie unburied in state archives amid doubts over their identity. Moscow creates taskforce to identify suspected remains of tsar's children 2015-07-10T04:00:00Z Dowsett suffers from haemophilia and hoped the event would raise awareness of the condition. Britain's Dowsett sets hour record 2015-05-02T04:00:00Z Genome-editing technologies may offer a powerful approach to treat many human diseases, including HIV/AIDS, haemophilia, sickle-cell anaemia and several forms of cancer3. Don’t edit the human germ line 2015-03-11T04:00:00Z Dogs first Dogs in haemophilia colonies often win researchers' hearts. In the Fight against Haemophilia, Dogs are a Weapon 2015-01-19T05:00:00Z The report says thousands of people in the UK - many of them with haemophilia - were infected when they were treated with blood products imported from the US in the 1970s and 80s. Infected blood legal case begins 2015-01-14T05:00:00Z Existing haemophilia treatments tip the balance towards clotting by adding what the body lacks—the clotting factor that is missing or defective. Time for a ‘Completely Different’ Haemophilia Treatment? 2015-01-12T05:00:00Z This led to long-lived tolerance in mouse models of haemophilia A and B. Lettuce Pills (You Heard That Right) May Help Treat Haemophilia 2015-01-07T05:00:00Z As a result of an inherited genetic mutation, people with haemophilia B lack a protein called factor IX that is crucial for forming blood clots. The Search for Genetic Treatments for Haemophilia is Proving Difficult 2014-12-29T05:00:00Z Movistar rider Dowsett, a haemophilia sufferer, wants to raise awareness about the condition with his bid to beat the distance next year. Dowsett in hour world record attempt 2014-12-19T05:00:00Z Earlier this year, the two researchers and their teams documented2 suppression of inhibitor formation and even reversal of pre-existing inhibitors in mouse models of haemophilia A. Immunology: Oral solutions : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The success was a crucial stepping stone for Edward Tuddenham, emeritus professor of haemophilia at University College London, who led the clinical trial. Gene therapy: Genie in a vector : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Earlier this year, the two researchers and their teams documented suppression of inhibitor formation and even reversal of pre-existing inhibitors in mouse models of haemophilia A. Lettuce Pills (You Heard That Right) May Help Treat Haemophilia 2015-01-07T05:00:00Z Replacing the clotting ability lacking in haemophilia has been the treatment since the 1840s, when attempts were made to treat people with the disease by transfusion with whole blood from people with normal clotting. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Yet haemophilia researchers are not inclined to speak enthusiastically of a cure. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Existing haemophilia treatments tip the balance towards clotting by adding what the body lacks — the clotting factor that is missing or defective. Thrombosis: Balancing act : Nature : Nature Publishing Group 2014-11-25T05:00:00Z When that was done, expression levels in a mouse model of haemophilia went from about 2% of that found in healthy mice to about 2,000%. Gene therapy: Genie in a vector : Nature : Nature Publishing Group 2014-11-25T05:00:00Z An X-ray of the knees of a person with haemophilia, both damaged from bleeding inside the joints. Orthopaedics: Joint effort : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Studies dating back to the 1970s have shown that PEGylation can reduce the chances of a foreign protein stimulating an immune reaction, although the effect has not yet been proved in people with haemophilia. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z History explains why people with haemophilia, and their physicians, are cautious to believe that a cure is in sight, says Stephen Pemberton. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Dogs in haemophilia colonies often win researchers' hearts. Animal models: Dogged pursuit : Nature : Nature Publishing Group 2014-11-25T05:00:00Z In practice, however, no responsible physician would expose an infant or child with a non-lethal disease such as haemophilia to chemotherapy. Gene therapy: Genie in a vector : Nature : Nature Publishing Group 2014-11-25T05:00:00Z People with the inherited bleeding disorder haemophilia lack factors that cause the blood to clot. Born in the blood : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Eloctate, for haemophilia A, was approved in June and is recommended for an initial infusion once every four days, with a physician adjusting that up to five days or down to three as appropriate. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Finally, there is the difficulty of making costly treatments available to the vast majority of the world's haemophilia patients who live in low income countries. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z In the 1970s and 1980s, before today's strict blood-donation regulations were introduced, thousands of people with haemophilia in the United States were infected with HIV from contaminated blood products. Policy: How to regulate faecal transplants 2014-02-19T18:50:53.475Z Correspondence from a haemophilia nurse confirmed no alternative method of transfusion acceptable to Jehovah's Witnesses was available. Jehovah's Witness 'can get blood' 2013-08-26T16:10:26Z Plasma Resources UK turns plasma - the watery fluid in blood that carries the white and red cells - into life-saving treatments for immune deficiencies, neurological diseases and haemophilia. Bain Capital buys majority stake in Plasma Resources UK 2013-07-18T19:03:00Z The researchers have not yet released the results of their phase II initial clinical trials, but Shima says that in the patients with haemophilia they looked at, bleeding frequency decreased dramatically. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The wants and needs of people with haemophilia in the developed world might not be the same as for those in low income countries. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Therapies using cells derived from fetuses are being developed to treat haemophilia and to help patients on chemotherapy fight off infection. A culture of consent 2013-06-26T17:20:00.783Z In a highly publicised case, a 15-year-old boy from a nomadic tribe in Iran's south-western province of Khuzestan died in July of haemophilia because his family did not have access to medicine. US Iranians send drugs to avert crisis 2013-01-11T01:02:52Z Women are thus carriers of, but rarely suffer from, diseases like haemophilia which are caused by the mutation of X-chromosome genes. Lifespan and the sexes: Catching up 2013-01-10T16:11:28Z “We think we can change the whole concept of haemophilia treatment,” Shima says. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Gene therapy is not even the most promising treatment for haemophilia on the immediate horizon. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z April Fool's Day was a non-fiction account of the death of his son, Damon, from Aids, contracted from a blood transfusion to treat haemophilia. Australian author Courtenay dies 2012-11-23T04:49:30Z Amid the shortage, Iranians in need of the chemotherapy, cardiac, diabetes, haemophilia and other drugs have turned to the large Iranian diaspora for informal help. US Iranians send drugs to avert crisis 2013-01-11T01:02:52Z In the 1930s, the pioneering geneticist J. B. S. Haldane noticed a peculiar inheritance pattern in families with long histories of haemophilia. Fathers bequeath more mutations as they age 2012-08-22T17:20:29.743Z About 30% of people with haemophilia A develop inhibitors, and once they do, treating their bleeding becomes much more difficult. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Regardless of the type of haemophilia, researchers remain hesitant about gene therapy owing to the unresolved ethical issues that arose decades ago. Perspective: The fix is in : Nature : Nature Publishing Group 2014-11-25T05:00:00Z After treatment, the animals' blood clotted in 44 seconds, compared with more than a minute for mice with haemophilia, and contained 3-7% of the typical amount of the missing factor. Cut-and-Paste Gene Repair Kit Fixes Mouse Hemophilia 2011-06-26T21:15:00.247Z The blood products were given to patients suffering with haemophilia and other bleeding disorders. Blood campaigners' plea rejected 2010-10-14T14:50:44Z Under current UK law this is not allowed, except in order to avoid gender-linked diseases, such as haemophilia and muscular dystrophy. Gender dilemma 2010-05-26T05:01:00Z Only about 4% of people with haemophilia B develop inhibitors to factor IX. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Biogen is developing clotting factors to treat haemophilia, an inherited disorder that impairs blood's ability to clot. UPDATE 1-Biogen gets manufacturing rights for hemophilia therapy 2010-02-18T08:24:00Z I know how you look down on our small size, our allergies and haemophilia and all the other weaknesses that have been bred back and preserved by the race. Planet of the Damned Factor IX — which people with haemophilia B lack — lasts longer, 18–24 hours. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Alprolix, the company's treatment for haemophilia B approved in March, promises infusions once a week, and perhaps every ten days or two weeks in some patients. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Extending the life of clotting factors may improve quality of life for people with haemophilia. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z “It's a big improvement,” says Timothy Nichols, a cardiologist and pathologist who studies haemophilia at the University of North Carolina at Chapel Hill. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Those short half-lives mean that most people with haemophilia must transfuse themselves every two or three days. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z |
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