| 单词 | haematopoietic |
| 例句 | In weeks, a single haematopoietic stem cell can replenish the entire human organism with new blood - and then, through yet unknown mechanisms, lull itself back to sleep. Cancer: The new normal? 2011-01-17T17:35:24Z Strimvelis is a form of gene therapy that uses a patient’s own haematopoietic stem cells, the precursor cells for blood and immune cells, to correct this mutation. Stem-cell and genetic therapies make a healthy marriage 2019-05-14T04:00:00Z These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis5,6,7. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity 2017-10-24T04:00:00Z Red blood cells produced from the edited haematopoietic stem cells of patients with sickle-cell disease produced 25% more fetal haemoglobin than unedited cells, and the edited cells successfully engrafted in mice. Gene therapy: Erasing sickle-cell disease : Nature : Nature Research 2017-09-26T04:00:00Z This DNA hypermethylation leads to changes in gene expression that promote the proliferation of long-lived TET2-mutant haematopoietic stem cells, and disrupt their differentiation into various types of blood cell, thereby promoting AML. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z Found in bone marrow, haematopoietic stem cells make all of the body's blood cells, including the immune cells that overreact in IBD. Cell-based therapy: Cells on trial : Nature : Nature Research 2016-12-20T05:00:00Z This study demonstrates that the structure of the haematopoietic hierarchy and the differentiation journeys downstream of HSCs change over a human lifetime. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z For example, these techniques offered only a limited ability to transfer genes into the most primitive progenitor cells, giving rise to the low-level and transient appearance of gene-corrected haematopoietic cells in vivo. Gene therapy returns to centre stage : Nature : Nature Publishing Group 2015-10-13T04:00:00Z In November 2016, the team successfully used the viral approach to edit haematopoietic stem cells from patients with sickle-cell disease in the lab. Gene therapy: Erasing sickle-cell disease : Nature : Nature Research 2017-09-26T04:00:00Z Helping someone who is in a dangerous situation earns between 300 and 500 points, and donating haematopoietic stem cells means 1,000 points. China: 'Morality bank' rewards good deeds - BBC News 2015-05-27T04:00:00Z Comparable results were obtained for multiple myeloma, colorectal adenocarcinoma and glioblastoma, where most of the significant features were measured in haematopoietic, intestine mucosa and brain tissues, respectively. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z A single cell resolution map of mouse haematopoietic stem and progenitor cell differentiation. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z HSC gene therapy is administered by ex vivo gene transfer into haematopoietic progenitors. Gene therapy returns to centre stage : Nature : Nature Publishing Group 2015-10-13T04:00:00Z At the European Hematology Association Annual Congress in June, the company presented the results of work involving normal human haematopoietic stem cells and recipient mice. Gene therapy: Erasing sickle-cell disease : Nature : Nature Research 2017-09-26T04:00:00Z One of the challenges in treating sickle-cell disease with gene therapy is that it is necessary to extract bone marrow to retrieve haematopoietic stem cells. Gene therapy: Editorial control : Nature : Nature Publishing Group 2014-11-11T05:00:00Z Thus, a deficit of RA signals within haematopoietic cells in early life results in small SLOs and poor capacity to control infection. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity 2014-04-04T18:28:57.531Z Human haematopoietic stem cell lineage commitment is a continuous process. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Her group has been using ZFNs to target CCR5 in haematopoietic stem cells, which can turn into several types of immune cell and might allow patients to make their own unending supply of resistant cells. Gene-editing Technique Shown to Work as HIV Treatment 2014-03-06T14:40:00Z Most solid tumours and haematopoietic malignancies display at least one form of genomic instability. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Doctors will first harvest bone marrow from the hip bones of patients with sickle-cell disease and then extract haematopoietic stem cells from the marrow. Gene therapy: Editorial control : Nature : Nature Publishing Group 2014-11-11T05:00:00Z These primitive cells, called haematopoietic stem cells, have the unique ability to divide indefinitely, making them essentially immortal. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z Diverse and heritable lineage imprinting of early haematopoietic progenitors. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z They saw a subsequent increase in the numbers of haematopoietic stem cells in the bloodstream. Painkillers Could Prove Helpful in Stem-Cell Transplants 2013-03-13T21:45:08.747Z Lyden speculates that age-related changes in the microenvironment, such as a shifting ratio of myeloid and lymphoid cells or a decrease in physical space for haematopoietic stem cells, might stimulate DTCs to resume their growth. Metastasis: The rude awakening 2012-05-30T17:51:07.740Z In sickle-cell disease, the only cells that need their DNA edited are blood stem cells — also known as haematopoietic stem cells — which are found in bone marrow. Gene therapy: Editorial control : Nature : Nature Publishing Group 2014-11-11T05:00:00Z In five of these individuals, haematopoietic stem cells in the bone marrow contained some of the same mutations present in the cancer cells. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z Human haematopoietic stem cell development: from the embryo to the dish. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z “There are neither scientific nor clinical data to support the long-term benefits of haematopoietic- or neural-stem-cell therapies for Parkinson’s patients,” he adds. China?s stem-cell rules go unheeded 2012-04-11T17:20:29.257Z In contrast, the ETP ALL signature showed significant positive enrichment of the gene expression profile of normal human haematopoietic stem cells and granulocyte macrophage precursors. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Could mutations in haematopoietic stem cells, which give rise to blood cells, lead to leukaemia? Stem cells: Bad seeds 2013-06-26T17:20:57.320Z Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Conversion of adult endothelium to immunocompetent haematopoietic stem cells. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Despite this diversity, the prevalence of mutations in genes involving cytokine receptor and RAS signalling, haematopoietic development and histone modification suggests a common pathogenesis for the establishment of the ETP leukaemic clone. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z Other researchers are looking for proteins present in leukaemia stem cells but not in normal haematopoietic stem cells. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z Just as haematopoietic stem cells can produce a vast array of blood cells, leukaemia stem cells generate the diversity of malignant cells seen in cancer. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Majeti's research suggests that researchers may need to target not only leukaemia stem cells, but also seemingly normal haematopoietic stem cells. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haematopoietic stem cells. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z His team reported that a subset of leukaemia cells that both carry CD34 and lack CD38 — the same markers that characterize haematopoietic stem cells — can seed leukaemia in mice. Stem cells: Bad seeds 2013-06-26T17:20:57.320Z |
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