| 单词 | glutamine |
| 例句 | DON was designed to starve cancer cells by mimicking glutamine, which unlike glutaminase blockers, broadly inhibits all metabolic pathways that use glutamine. Newfound mechanism suggests drug combination could starve pancreatic cancer 2023-10-09T04:00:00Z In the absence of oxygen, cancer cells resort to a very specific survival mechanism: they metabolise the amino acid glutamine as an alternative source of energy through a chemical reaction known as ''reductive carboxylation''. Strengthening artificial immune cells to fight cancer 2023-09-20T04:00:00Z One important limitation of the study is that the scanners used aren’t powerful enough to distinguish between glutamate and another closely related molecule, glutamine, notes Alexander Lin, a clinical spectroscopist at Brigham and Women’s Hospital. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z The allele for this disease contains a long string of bases in which the codon for the amino acid glutamine repeats over and over again. Miller & Levine Biology 2018-01-01T00:00:00Z The researchers found that the drug wasn’t just throttling glutamine metabolism. Revamped cancer drug starves tumors in mice 2019-11-07T05:00:00Z Moving forward, the research team will seek to understand how glutamine antagonism impacts other adaptive nutrient scavenging mechanisms in pancreatic cancers and whether these could be targeted as well. Newfound mechanism suggests drug combination could starve pancreatic cancer 2023-10-09T04:00:00Z Similar to classical eukaryotic release factor 1, Vms1 activity is dependent on a conserved catalytic glutamine. Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes 2018-04-08T04:00:00Z Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Asparagine bioavailability governs metastasis in a model of breast cancer 2018-02-06T05:00:00Z A glutamine in the selectivity filter may be an important determinant of monovalent selectivity. Electron cryo-microscopy structure of a human TRPM4 channel 2017-12-05T05:00:00Z “This paper is the first to show that the response to glutamine inhibition in T cells and cancer cells is different.” Revamped cancer drug starves tumors in mice 2019-11-07T05:00:00Z In genetically engineered lung and pancreatic cancer tumours in fasted mice, the contribution of circulating lactate to TCA cycle intermediates exceeds that of glucose, with glutamine making a larger contribution than lactate in pancreatic cancer. Glucose feeds the TCA cycle via circulating lactate 2017-10-17T04:00:00Z “You block glucose, they use glutamine,” Dang says, in reference to another primary fuel used by cancers. An Old Idea, Revived: Starve Cancer to Death 2016-05-12T04:00:00Z "This includes zinc, vitamin C, arginine and glutamine." Dietary Supplements During Cancer Treatment: Yes or No? 2015-07-01T04:00:00Z A 2002 review found that glutamine supplementation lowered the risk of infections after surgery. For many, gluten isn’t the villain it gets cracked up to be 2015-06-29T04:00:00Z Starting in the 1950s, researchers tried to turn tumors’ glutamine dependence against them, developing drugs to block its metabolism. Revamped cancer drug starves tumors in mice 2019-11-07T05:00:00Z In a trial of six patients with a type of deadly brain cancer called glioma, the tracer -- which tracked a nutrient called glutamine -- clearly showed the edges of tumors. New Techniques Outline Tumors' Location in the Brain 2015-02-13T05:00:00Z “You block glucose and glutamine, they might be able to use fatty acids. We don’t know yet.” An Old Idea, Revived: Starve Cancer to Death 2016-05-12T04:00:00Z “There was strong evidence that glutamine in a good-tasting solution works,” Anderson said. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z The hope, says Calithera chief executive Susan Molineaux, is that because of cancer cells’ strong dependence on glutamine, concentrations of the inhibitor can be found that will halt cancerous growth without damaging healthy cells. Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z A bacteria-derived compound called DON, for instance, kills tumors by inhibiting several enzymes that allow cancer cells to use glutamine. Revamped cancer drug starves tumors in mice 2019-11-07T05:00:00Z Harper pours glutamine powder into yogurt-and-fruit shakes and drops amino vitamins into homemade organic juice. Nationals star Bryce Harper works hard to take care of his body 2014-03-26T22:10:31Z The parasite, however, is floating around in your bloodstream with a pretty stable environment and a constant supply of glucose and glutamine. Understanding the Malaria-Causing Parasite 2010-08-06T17:55:00Z “It took both the sugar and the glutamine to get the glutamine into the cells,” he said. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z The company has produced a drug that blocks glutaminase, the enzyme that converts glutamine to glutamate, a key step in the cycle. Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z So Anderson consulted a University of Minnesota pharmacist who helped him develop a sweetened glutamine liquid that was tested in three randomized, double-blind, placebo-controlled studies. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z After workouts, to maximize recovery and eliminate cramping, Harper uses glutamine powder. Nationals star Bryce Harper works hard to take care of his body 2014-03-26T22:10:31Z When he searched the medical literature to find out “what makes healing faster,” he learned that “critically ill patients did better if they had some glutamine.” Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z Sprinkling glutamine on food wouldn’t help if mouth sores made it hard for a child to chew or swallow. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z Separately, Miniex said she had been reading about the effects of glutamine to hasten healing. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z But the answer wasn’t as simple as buying glutamine in a health food store. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z Instead of the “messy, sticky solution,” they came up with Healios, a powder of glutamine and sugars that can be mixed with water. Cancer specialist’s treatment helps patients eat 2015-01-03T05:00:00Z |
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