| 单词 | glutamate |
| 例句 | This resulted in the substitution of one amino acid for another: glutamate was switched to valine. The Gene 2016-06-02T00:00:00Z Rife on the shores of the Korean Peninsula, seaweed is harvested, then sold in many forms — especially raw, dried and roasted — and can increase the glutamate quotient in certain beloved dishes. Umami Is Often a Flavor Bomb. In This Creamy Pasta, It’s a Balm. 2021-03-26T04:00:00Z People with chronic dryness need not be limited to a liquid diet, says Smith, because the glutamate in umami ingredients – the likes of miso, soy, mushrooms, balsamic vinegar – helps to stimulate saliva. Pineapple tacos, duck doughnuts and apple beer: how cancer patients are being tempted to eat well 2018-07-30T04:00:00Z These are built on foundations of salt and monosodium glutamate, artificial flavors, artificial colors, polysyllabic ingredients that are difficult to pronounce much less identify. The Improbable Rise of Mississippi Roast 2016-01-25T05:00:00Z He draws a distinction between naturally occurring glutamate in food and the synthetic powder. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z Then I realized that two of the first three ingredients are corn syrup and monosodium glutamate. It Came, It Quenched, It Conquered Canada: The Caesar 2018-01-11T05:00:00Z June S.: MSG, also known as monosodium glutamate, is a flavor enhancer that is used in a number of Chinese dishes, soups and processed meats. Perspective | Hints From Heloise: The best gift 2019-03-14T04:00:00Z But it’s just a sodium ion attached to glutamate, which is something your body produces naturally and needs to function. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z Glutamic acid, or glutamate, occurs naturally in all kinds of foods, from mushrooms to tomatoes, dry-aged meat, soy sauce and Parmesan. Where do we stand with MSG? 2022-08-07T04:00:00Z Malt is like a sweet version of umami, the so-called fifth flavor that pops up in ingredients like soy, mushrooms and monosodium glutamate. A Malted Milk Crawl in New York 2014-06-30T04:00:00Z Another key cause of hangxiety is being unable to remember the mortifying things you are sure you must have said or done while inebriated – another result of your compromised glutamate levels. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z Monosodium glutamate, a staple of Chinese food, contains about a third of the sodium of table salt, and may actually help reduce salt consumption. How to order a healthier Chinese takeaway: swap noodles for rice and avoid the soup 2018-03-13T04:00:00Z Amino acid compounds, such as glutamate and aspartate as well as substances derived from nucleic acids dissolved in the cells of some algae, especially nori, are a source of umami flavour. A gourmet revival for St. Lawrence River marine algae 2022-09-11T04:00:00Z In 1908, he patented a process for extracting glutamate from seaweed and stabilising it with salt to create monosodium glutamate, a product thereafter known as Aji-No-Moto – “essence of taste”. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z When you stop drinking, therefore, you end up with unnaturally low Gaba function and a spike in glutamate – a situation that leads to anxiety, says Nutt. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z And then, you do a little more research and realize that MSG is a synthetic additive, but that replicates a naturally occurring thing in your tasters, which is to activate your glutamate receptor. BonAp food boss Carla Lalli-Music: Not only is MSG okay, it is a core staple in the pantry 2019-03-30T04:00:00Z When you are drunk, your body goes on a mission to bring Gaba levels down to normal and turn glutamate back up. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z Chemically speaking, no analytical method can differentiate between added and naturally occurring glutamate. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z Foods with umami are high in the amino acid glutamate and have a complex, meaty and savory flavor profile. If you’re craving comfort, this umami-rich pasta is bound to satisfy 2023-01-16T05:00:00Z “Alcosynth”, as it is currently called, drowns your sorrows in the same way as alcohol, but without knocking the Gaba and glutamate out of kilter. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z The usual suspects for triggering migraines include aged cheese, processed meats, additives such as monosodium glutamate and aspartame, and even chocolate. Perspective | Her anti-migraine hacks include avoiding red wine and wearing sunglasses 365 days a year 2019-11-05T05:00:00Z Dashi is a very good representative of the umami taste as its cooking process results in the extraction of a large amount of glutamate. A gourmet revival for St. Lawrence River marine algae 2022-09-11T04:00:00Z Modernist chefs argue that MSG is just a handy form of the glutamate in tasty, natural foods, and no more sinister. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z With his newfound knowledge, Ikeda went on to found the company Ajinomoto and started mass producing the food additive monosodium glutamate or MSG. Scientists suggest a sixth basic taste: ammonium chloride 2023-10-30T04:00:00Z The average person eats 13 grams of naturally occurring glutamates each day, while glutamate intake from using MSG as an additive averages out to just over half a gram per day. Where do we stand with MSG? 2022-08-07T04:00:00Z Manufacturers use MSG and other glutamate additives to mimic natural savoury flavours in ultra-processed products such as soup mixes, readymade sauces, savoury snacks, seasoned nuts, stock cubes and instant noodles. Chinese restaurant syndrome: has MSG been unfairly demonised? 2018-05-21T04:00:00Z Drying the mushrooms further intensifies the glutamate — by as much as 15 times. This pantry ingredient will change how you cook salmon 2021-06-20T04:00:00Z This new endeavor involves the closely guarded secret behind the production of a powdered drug called Glow — "a mixture of speed, monosodium glutamate and an experimental anxiety disorder medication for dogs." Ned Beauman's 'Glow' puts an unconventional spin on a thriller plot 2015-01-30T05:00:00Z Eventually, Ikeda found that the taste, which he called “umami,” was made of glutamate, an amino acid that is one of the building blocks of protein. Scientists suggest a sixth basic taste: ammonium chloride 2023-10-30T04:00:00Z If you dab a bit of MSG — as in, the isolated amino acid glutamate attached to sodium — on your tongue, it tastes a little like dried meat. Why is umami so hard to describe? 2022-10-02T04:00:00Z Maybe they are the literary equivalent of monosodium glutamate — having no substance of their own, but enhancing what is around them? Gene Weingarten: Admit it. You don’t know what ‘epistemological’ means either. 2016-05-10T04:00:00Z The differences are stylistic, he said, but “related in glutamate.” You Think You Know Umami 2015-03-19T04:00:00Z Imbalances in Gaba and glutamate are not the only problem. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z When you get to the third or fourth drink, another brain-slackening effect kicks in: you start blocking glutamate, the main excitatory transmitter in the brain. ‘Hangxiety’: why alcohol gives you a hangover and anxiety 2019-01-27T05:00:00Z “It targets the glutamate system, which is a fast-acting system that no other major antidepressant targets.” Why 'big pharma' stopped searching for the next Prozac 2016-01-27T05:00:00Z All that makes sense, because amino acids are the building blocks of proteins and the amino acid glutamate is found in foods with the umami taste. Does chicken soup really help when you’re sick? A nutrition specialist explains 2023-10-23T04:00:00Z It targets a chemical messenger in the brain called glutamate that regulates memory, cognition and mood. For some, the drug ketamine can be a lifesaver. But recent shortages have made it hard to get 2023-11-15T05:00:00Z Ketamine targets a brain chemical messenger called glutamate, which is thought to play a role in both pain and depression. Mind-altering ketamine becomes new pain treatment, despite little research or regulation 2023-11-06T05:00:00Z Some GPCRs worked as expected, but others didn't, notably those for neurotransmitters called glutamate. Scientists train AI to illuminate drugs' impact 2023-10-31T04:00:00Z The findings are based on results of functional MRI brain scans, sophisticated statistical modeling techniques, and analyses of metabolites of the glutamate pathway in the digestive tract. Discrimination alters brain-gut 'crosstalk,' prompting poor food choices and increased health risks 2023-10-02T04:00:00Z These cells are models in neuroscience because they exhibit many fundamental properties common to neurons in people and other animals, including communication via the release of the neurotransmitter glutamate. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z The neurotransmitter itself is thought to be glutamate. Fundamentals of Biology 2015-01-01T00:00:00Z But there’s one known mutation, dubbed E627K, that does so in a single bound by swapping an amino acid at a key position, a glutamate, for a lysine. From bad to worse: How avian flu must change to trigger a human pandemic 2023-04-06T04:00:00Z It is one of the world’s largest producers of monosodium glutamate, a flavor enhancer. Pentagon: Proposed Chinese plant near N. Dakota base ‘threat to national security’ 2023-02-01T05:00:00Z Through analysis of fecal samples, the researchers looked for changes in 12 glutamate metabolites -- substances resulting from the breakdown of glutamate. Discrimination alters brain-gut 'crosstalk,' prompting poor food choices and increased health risks 2023-10-02T04:00:00Z In more than a decade of studies, Littleton's lab has shown that a protein called Complexin has the job of restraining spontaneous glutamate chatter. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z Transcranial magnetic stimulation causes increases in both blood flow and in the levels of dopamine and glutamate — two neurotransmitters that are responsible for brain functions like concentration, memory and sleep. Patients suffering with hard-to-treat depression may get relief from magnetic brain stimulation 2022-12-06T05:00:00Z When THC enters receptors in the hippocampus, it may trigger the release of more glutamate, a neurotransmitter important for forming memories. Does pot really make your memory worse? Here's what the science says 2022-10-17T04:00:00Z The development of schizophrenia is thought to involve malfunctioning dopaminergic neurons and may also involve problems with glutamate signaling. Biology for AP Courses 2022-06-09T00:00:00Z Many neurotransmitters are used in this section of the brain — including glutamate, which plays a significant role in memory and learning. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z The result was a blend of the two: reduced spontaneous glutamate release than with just the weakly clamping edition alone. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z But typical neuronal responses, such as those involving glutamate, happen within milliseconds. Newfound Molecular Switch Signals a Thumbs-up or Thumbs-down in the Mouse Brain 2022-08-12T04:00:00Z But the brain seems to recognize there's too much glutamate, so it downregulates — or turns off — the receptors glutamate needs to stick to form memories. Does pot really make your memory worse? Here's what the science says 2022-10-17T04:00:00Z In fact, monosodium glutamate, or MSG, is often used in cooking to enhance the savory taste of certain foods. Biology for AP Courses 2022-06-09T00:00:00Z That build-up of glutamate can be a bad thing for your brain because, if it has to focus on regulating glutamate, the brain then has less control over decision-making. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z The findings suggest that not only does each edition potentially fine-tune glutamate release, but that combinations among them can act in a combinatorial fashion. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z Wiehler and his colleagues’ new study suggests possible distinctions between subjective feelings of fatigue and more objective measures of mental exhaustion, such as the changes in glutamate concentration the team observed. Why Thinking Hard Wears You Out 2022-08-11T04:00:00Z Now, a study hints at why we get so unraveled after hours of hard mental labor: a toxic buildup of glutamate, the brain’s most abundant chemical signal. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z In normal hemoglobin, the amino acid at position seven is glutamate. Biology for AP Courses 2022-06-09T00:00:00Z Yet glutamate can build up in one's brain, for reasons ranging from traumatic stress to physical illness — and often for reasons that remain mysterious. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z One, which occurs more commonly, proved to be a less effective clamp than unedited Complexin, barely preventing spontaneous glutamate release and upticks in electrical current. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z When the researchers looked at glutamate in the primary visual cortex—another brain area activated during the experiment because of its role in vision—they found no such changes. Why Thinking Hard Wears You Out 2022-08-11T04:00:00Z In the new study, researchers looked at whether levels of glutamate are related to behavior that so often manifests when we’re mentally exhausted. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z In sickle cell hemoglobin, this glutamate is replaced by a valine. Biology for AP Courses 2022-06-09T00:00:00Z That build-up of glutamate can be a bad thing for your brain because, if it has to focus on regulating glutamate, the brain then has less control over decision-making. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z The other turned out to be more effective at clamping than the unedited version, keeping a tight lid on glutamate release and synaptic output. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z In the future, therapeutics aimed at reversing the buildup of glutamate may help boost these individuals’ ability to sustain attention for long periods of time. Why Thinking Hard Wears You Out 2022-08-11T04:00:00Z The scientists used a noninvasive technique called magnetic resonance spectroscopy, which can detect glutamate through a combination of radio waves and powerful magnets. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z The hyperpolarized membrane does not release glutamate to the bipolar cell. Biology for AP Courses 2022-06-09T00:00:00Z If your brain has to focus on regulating glutamate, you have less control over your decision-making. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z The amino acid neurotransmitters, glutamate, glycine, and GABA, are almost exclusively associated with just one effect. Anatomy and Physiology 2013-06-19T00:00:00Z The presence of glutamate as a biological marker might shed light on why patients struggle with exhaustion. Why Thinking Hard Wears You Out 2022-08-11T04:00:00Z At the same time, their glutamate levels rose by about 8% in the lateral prefrontal cortex—a pattern that did not show up in the other group, the scientists report today in Current Biology. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z Removal of CaMBD enables increased activity of the enzyme glutamic acid decarboxylase, which catalyzes the decarboxylation of glutamate to GABA, thus raising levels of the molecule. CRISPR-edited Tomatoes Are Supposed to Help You Chill Out 2021-12-24T05:00:00Z "It would be great to find out more about how glutamate levels are restored," Wiehler explained. This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z Figure 13.10 Connections of Basal Nuclei Input to the basal nuclei is from the cerebral cortex, which is an excitatory connection releasing glutamate as a neurotransmitter. Anatomy and Physiology 2013-06-19T00:00:00Z Besides soy and oyster sauce, Foshan Haitian develops, makes, and distributes other products including vinegar, chicken stock, monosodium glutamate, and oil. Inflation: Price of top China soy sauce raised as costs surge 2021-10-13T04:00:00Z It might be possible to use glutamate levels in the prefrontal cortex to detect severe fatigue and monitor recovery from conditions such as depression or cancer, the team suggests. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z Some investigators are concentrating on preventing spinal neurons from responding to neurotransmitters released by nociceptors—particularly to the amino acid glutamate, the primary carrier of the pain message. Toward Better Pain Control 2021-10-10T04:00:00Z "I would employ good old recipes: rest and sleep. There is good evidence that glutamate is eliminated from synapses during sleep." This is what happens inside your brain when you feel burnt out 2022-08-17T04:00:00Z In conditions of low glucose, such as fasting, starvation, or low carbohydrate diets, glucose can be synthesized from lactate, pyruvate, glycerol, alanine, or glutamate. Anatomy and Physiology 2013-06-19T00:00:00Z Aaron Hutcherson made an excellent case that monosodium glutamate does not deserve its “bad rap” in his Sept. 15 Food essay, “Want bold flavor? Give MSG a chance.” Opinion | Readers critique The Post: Surprised to see my brother’s tractor 2021-09-24T04:00:00Z Abnormal glutamate signaling occurs in many brain disorders. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z Monosodium glutamate, more commonly known as MSG, has been around for more than a century. Why you shouldn’t fear MSG, an unfairly maligned and worthwhile seasoning 2021-08-27T04:00:00Z In this regard, considerable evidence has demonstrated that the regulation of two receptors—AMPA and NMDA—on many neurons that respond to the neurotransmitter glutamate control changes in the tiny junctions, or synapses, between neurons. Novel Drug Therapies Could Tackle Treatment-Resistant Depression 2021-09-14T04:00:00Z They said his body had been turned into “vetsin” powder, or monosodium glutamate. The indignity of Philippines' 'homeless' dead: leased graves that expire 2021-03-03T05:00:00Z In anti-NMDA receptor encephalitis, for example, the immune system attacks glutamate receptors on neurons in the brain, sometimes provoking behavior that resembles what’s seen in schizophrenia. What If You Never Get Better From Covid-19? 2021-01-21T05:00:00Z One important limitation of the study is that the scanners used aren’t powerful enough to distinguish between glutamate and another closely related molecule, glutamine, notes Alexander Lin, a clinical spectroscopist at Brigham and Women’s Hospital. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z However, per the FDA, “The glutamate in MSG is chemically indistinguishable from glutamate present in food proteins. Our bodies ultimately metabolize both sources of glutamate in the same way.” Why you shouldn’t fear MSG, an unfairly maligned and worthwhile seasoning 2021-08-27T04:00:00Z The first gene encodes a channel activated by the neurotransmitter molecule glutamate. The brain rhythms that detach us from reality 2020-09-15T04:00:00Z In module I, the glucose-derived amino acid glutamate is converted to another amino acid, arginine, in a series of reactions that occurs partly in the mitochondrion. Genetically engineered yeast makes medicinal plant products 2020-09-01T04:00:00Z Also, the first ingredient listed on Goya’s original sazón is the flavor enhancer MSG, or monosodium glutamate. You can make sazón at home. All you need are some common kitchen spices. 2020-07-21T04:00:00Z But the findings “provide the basis for examining how glutamate could potentially be modulated by medications or devices such as neurostimulation,” he says. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z “A dish that serves four to six people, or a pound of meat, needs 1/4 to 1/2 teaspoon of monosodium glutamate,” wrote Danilo Alfaro in the Spruce Eats. Why you shouldn’t fear MSG, an unfairly maligned and worthwhile seasoning 2021-08-27T04:00:00Z These studies also found that the hypothermia-causing preoptic neurons release the excitatory molecule glutamate as their main neurotransmitter, rather than GABA. Flipping the switch on the body’s thermoregulatory system 2020-06-10T04:00:00Z In fresh shiitake, these two substances are present in very low amounts, but during drying, the glutamate is concentrated and GMP is released through an enzyme reaction. How to make the most flavorful vegetable stock 2020-05-08T04:00:00Z MSG comes from glutamate, a common amino acid or protein building block found in food. Merriam-Webster revises ‘Chinese restaurant syndrome’ entry 2020-05-22T04:00:00Z He suspects instead that the uptick in glutamate as the brain tires serves a purpose. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z The mother brand is Lao Gan Ma, which started making the sauce in China’s Guizhou province in the late 1990s, run through with monosodium glutamate and a faint whisper of sugar. Your Quarantine Cooking Needs Condiments 2020-04-13T04:00:00Z First, he wanted to understand the molecular basis of LTP, and explored, for example, the role of specific subtypes of receptors for the neurotransmitter glutamate. Per Andersen (1930–2020) 2020-03-19T04:00:00Z It works by blocking a receptor for glutamate in the brain but it doesn’t work equally well for everyone. From depression to dementia, inflammation is medicine’s new frontier | Edward Bullmore 2020-01-19T05:00:00Z The definition described symptoms affecting “susceptible persons eating food and especially Chinese food heavily seasoned with monosodium glutamate.” The Campaign to Redefine ‘Chinese Restaurant Syndrome’ 2020-01-16T05:00:00Z Maybe the prefrontal cortex’s glutamate is sending a similar status update to the brain’s internal monitoring system, Musslick suggests. Mentally exhausted? Study blames buildup of key chemical in brain 2022-08-11T04:00:00Z It affects people eating food but “especially Chinese food heavily seasoned with monosodium glutamate.” Asians cringe at ‘Chinese food syndrome’ entry in dictionary 2020-01-14T05:00:00Z It affects people eating food but “especially Chinese food heavily seasoned with monosodium glutamate.” Asians cringe at ‘Chinese food syndrome’ entry in dictionary 2020-01-14T05:00:00Z Baker has dedicated his career to understanding how glutamate can treat disorders of the brain. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z The doctors speculated that the cause was a preservative — monosodium glutamate, or MSG. The Campaign to Redefine ‘Chinese Restaurant Syndrome’ 2020-01-16T05:00:00Z Alcohol consumption also affects a variety of neurotransmitter systems in the brain, including glutamate, dopamine and serotonin. Hangovers happen as your body tries to protect itself from alcohol’s toxic effects 2020-01-01T05:00:00Z They want a little less soy and a bit more umami – that elusive, savory monosodium glutamate flavor. Inside the world of flavorists, who try to make plant-based meat taste like the real thing 2019-11-10T05:00:00Z They want a little less soy and a bit more umami — that elusive, savory monosodium glutamate flavor. Inside the little-known world of flavorists, who are trying to make plant-based meat taste like the real thing 2019-11-04T05:00:00Z Given the importance of glutamate to nearly every brain function, there is a genuine, and well-reasoned, concern among both neuroscientists and psychiatrists that glutamatergic therapeutics will produce widespread impairments in the brain. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Hanahan and his colleagues showed that when breast-cancer cells infiltrate the brain, they form a specialized type of synapse that allows them to soak up a chemical called glutamate. Cancer cells have ‘unsettling’ ability to hijack the brain’s nerves 2019-09-17T04:00:00Z Both groups also engineered human glioma cells to express a light-activatable version of an ion channel that produces cellular depolarization, similar to that obtained by the synaptic-mediated activation of glutamate receptors. Dangerous liaisons as tumour cells form synapses with neurons 2019-09-17T04:00:00Z It also identified the neurotransmitter glutamate as a key mediator of the protein’s role in the stress response. Fight or Flight May Be in Our Bones 2019-09-12T04:00:00Z Among people with PTSD, those who had experienced suicidal thoughts had 30% more receptors for the signaling molecule glutamate, suggesting they were making less glutamate and the brain was struggling to compensate. Brain scans could help personalize treatment for people who are depressed or suicidal 2019-08-20T04:00:00Z But Baker believes that the key to treating diseases of the brain can be found in the complexity of glutamate signaling. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z That set expressed the gene for an excitatory signaling molecule, glutamate. Sweet, fatty foods could remodel the brain to drive overeating 2019-06-27T04:00:00Z Zeng and colleagues investigated the role of glutamate-mediated signalling in tumours by examining the expression of glutamate receptors in many different sorts of human cancer. Dangerous liaisons as tumour cells form synapses with neurons 2019-09-17T04:00:00Z We also found that p11 interacts with glutamate receptors, which are also linked to depression. Nobel Laureate Paul Greengard Kept Churning Out Ideas for New Drugs after Turning 90 2019-04-15T04:00:00Z Her finding also engendered hope that ketamine, a drug that targets glutamate, might help people in that group. Brain scans could help personalize treatment for people who are depressed or suicidal 2019-08-20T04:00:00Z “If so, we may be able to selectively target specialized forms of glutamate signaling, which could revolutionize how we conceive of and treat complex brain disorders,” says Baker. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z “We know where in the brain alcohol has its ‘good’ effects and ‘bad’ effects, and what particular receptors mediate that – Gaba, glutamate and other ones, such as serotonin and dopamine. An innocent drink: could ‘alcosynth’ provide all the joy of booze – without the dangers? 2019-03-26T04:00:00Z These intriguing findings raise the possibility that approaches targeting specific types of glutamate receptor, postsynaptic signalling processes or the mechanisms needed for synapse formation might provide therapeutic targets for slowing tumour proliferation. Dangerous liaisons as tumour cells form synapses with neurons 2019-09-17T04:00:00Z Esketamine instead targets glutamate, a chemical linked with learning and memory, and generally considered the most essential for normal brain function. Anti-depression drug spray approved in US 2019-03-06T05:00:00Z Esketamine affects the receptor for a different brain chemical called glutamate. In biggest advance for depression in years, FDA approves novel treatment for hardest cases 2019-03-06T05:00:00Z Baker notes that glutamate receptors are found in every kind of brain cell, which means it is doing more than regulating the activity of neurons, it is regulating the brain’s support cells too. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Esketamine, on the other hand, targets a different chemical, called glutamate. FDA approves ketamine-derived depression drug 2019-03-05T05:00:00Z At the time, glutamate had mostly been studied for its role in learning and memory. Party-Drug-Turned-Antidepressant Approaches Approval 2019-02-22T05:00:00Z But in mammals, glutamate is the main excitatory neurotransmitter that is responsible for driving excess activity during seizures, and none of its receptors is inhibitory. Gene therapy targets epilepsy 2018-12-11T05:00:00Z The prevailing theory is that it affects the brain’s glutamate system, which scientists now realize may be involved in depression, rather than the better-known serotonin pathway used by drugs like Prozac. Opinion | Can We Stop Suicides? 2018-11-30T05:00:00Z Although glutamate is not widely targeted for therapeutic purposes because of its involvement in so many brain functions, that doesn’t mean that tapping into elements of the glutamate system is impossible, as Baker has demonstrated. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z The researchers think the differences in the hippocampus stem from changes in levels of glutamate, the brain’s main excitatory neurochemical involved in learning and memory. How marijuana harms a developing baby’s brain 2018-11-18T05:00:00Z He demonstrated familiarity with, if not authority about, fermented black beans, Chinese five spice, Chinese barbecue pork and even monosodium glutamate, or MSG, which he wholeheartedly embraced as a flavor enhancer. Review | With tiki drinks and Chinese food, this U Street bar channels Trader Vic’s for millennials 2018-11-05T05:00:00Z The other class, excitatory neurons, uses the chemical glutamate and they serve as the brain's main cells for generating neural activity. New Atlas Used to ID Brain Parts for Plans and Actions 2018-11-01T04:00:00Z Animal research suggests that partly blocking certain glutamate receptors increases brain plasticity — the ability of the brain to make new neuronal connections — and corrects some of the abnormalities that result from chronic stress. Opinion | Can We Stop Suicides? 2018-11-30T05:00:00Z “The function of most, if not all, of the trillions of cells in the brain are regulated by glutamate,” neuroscientist David Baker explains to me. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z This chemical acts like a puppet master in the brain, regulating glutamate and other important neurochemicals; high levels of the molecule result in lower glutamate levels. How marijuana harms a developing baby’s brain 2018-11-18T05:00:00Z For example, in the hippocampus, they nestle closer to excitatory neural synapses and respond more robustly to the neurotransmitter glutamate than do those in the striatum. Tapping into the brain’s star power 2018-10-30T04:00:00Z Alcohol alters the activity of certain glutamate receptors, thereby boosting the production of specific steroid hormones. What Causes Alcohol-Induced Blackouts? 2018-10-26T04:00:00Z How did this combination of sodium and glutamate, found naturally in many foods — including Parmesan cheese, ripe tomatoes, seaweed, dry-aged beef and human breast milk — become a dietary devil? Avoiding MSG? Look beyond the myths 2018-10-17T04:00:00Z Specifically, his hopes for targeting glutamate lie in a mechanism called system xc-. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Unlike traditional antidepressants that target the brain’s serotonin and noradrenaline systems, ketamine appears to block a receptor called NMDA, which is activated by the neurotransmitter glutamate. Is the Ketamine Boom Getting Out of Hand? 2018-09-26T04:00:00Z They applied glutamate, an important neurotransmitter that helps neurons communicate in animals. Watch Plants Light Up When They Get Attacked 2018-09-13T04:00:00Z Further study pinpointed glutamate as the trigger of the calcium wave. Plants communicate distress using their own kind of nervous system 2018-09-13T04:00:00Z Curious, he cooked dashi down until it crystallized, and discovered that those crystals were made of glutamate and salt from the sea. Avoiding MSG? Look beyond the myths 2018-10-17T04:00:00Z System xc- is one of these specialized forms of glutamate signaling; it is a way in which the brain exchanges amino acids across the cellular membrane. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z And the ingredients Trump wants to tax read like a stir-fry recipe: abalone, sea urchins, garlic, bamboo shoots and dried mushrooms — not to mention monosodium glutamate, the flavor-enhancer commonly known as MSG. Trump's trade war is about to hit home — and yours is no exception 2018-07-11T04:00:00Z The messages start at the point of attack, where glutamate initiates a wave of calcium that propagates through the plant’s veins, or plumbing system. Watch Plants Light Up When They Get Attacked 2018-09-13T04:00:00Z It works by blocking some of the neurotransmitter pathways in the brain, as well as tamping down the effect of glutamate. Unlocking Secrets of Sour Flavors With Something Found in Your Ears 2018-02-03T05:00:00Z The cells lining your intestine use almost all the glutamate you get from food to fuel their constant regeneration. Avoiding MSG? Look beyond the myths 2018-10-17T04:00:00Z What Baker came to realize is that glutamate may be playing an even bigger role in areas other than the synapses within the brain. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Booze acts as a red light for glutamate and a green light for Gaba. How I let drinking take over my life 2018-01-05T05:00:00Z The drug is not an antipsychotic, but instead strengthens the signaling of glutamate, a neurotransmitter that's impaired in people with schizophrenia and those at risk. Scientists are learning to predict psychosis years in advance—and possibly prevent it 2017-11-16T05:00:00Z Then the biofilms would stop expanding until the glutamate was replenished. Bacteria Use Brainlike Bursts of Electricity to Communicate 2017-09-09T04:00:00Z Increased adenosine, he says, reduces the release of the signaling molecule glutamate in the thalamus, which in turn diminishes the activity of neurons in the auditory cortex. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z Baker notes that almost none of the most commonly prescribed drugs for psychiatric disorders target glutamate. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Some OCD researchers now hypothesise that SSRIs work not because of serotonin, but because they stop the release of glutamate. Is your dog just chasing its tail – or is it obsessive? 2017-06-25T04:00:00Z Its limited effect on life span — an extension of a few months — suggests that excess glutamate is hardly the only noxious factor involved in the disease. A New Drug for A.L.S., but the Diagnosis Remains Dire 2017-05-29T04:00:00Z In these experiments, two bacterial communities took turns eating glutamate, enabling the biofilms to consume the limited nutrients more efficiently. Bacteria Use Brainlike Bursts of Electricity to Communicate 2017-09-09T04:00:00Z Introduction of the catalytic glutamate substitutions does not affect the distance changes. Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein : Nature : Nature Research 2017-03-12T05:00:00Z Hess is thinking about these human conditions, but he’s also thinking a little further back, spearheading a new evolutionary angle to the glutamate story in Baker’s lab. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z This area is dominated by glutamate pathways that are thought to generate controlled movement and thought, and to modulate behavioural routines. Is your dog just chasing its tail – or is it obsessive? 2017-06-25T04:00:00Z What my tongue sensed when I sipped that fluid was a substance called glutamate. Why tomato is the world's favoured fruit - BBC News 2017-03-02T05:00:00Z Another type of glial cell, the astrocyte, provides motor neurons with nutrients, ion buffering and recycling of the neurotransmitter glutamate. Decoding ALS: from genes to mechanism : Nature : Nature Research 2016-11-08T05:00:00Z Introduction of the catalytic glutamate substitutions does not affect the distance changes. Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein : Nature : Nature Research 2017-03-12T05:00:00Z As brains became more complex, synaptic glutamate was no longer enough. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z In the patients who also got the glutamate drug, symptoms reduced by 27% on average, compared with 16.5% in the other group. Is your dog just chasing its tail – or is it obsessive? 2017-06-25T04:00:00Z Whenever you eat a food that contains glutamate, the glutamate molecules in the food trigger special receptors on your tongue. Why tomato is the world's favoured fruit - BBC News 2017-03-02T05:00:00Z The other, guanfacine, is currently used to treat high blood pressure and is thought to keep sensory neurons from releasing glutamate into the spinal cord. Why painkillers sometimes make the pain worse 2016-11-03T04:00:00Z He explains that all the glutamate receptors seem to interact with each other as well, and act as a complicated system. Novel drugs for depression 2016-10-13T04:00:00Z Specifically, system xc-’s uptake of one molecule of cystine leads to the release of one molecule of glutamate from the cell. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z In the brain, CDH2 is involved in the development of glutamate receptors. Is your dog just chasing its tail – or is it obsessive? 2017-06-25T04:00:00Z One 1948 research paper observed, “It seems that glutamate is successful not because it adds taste, but because it adds feeling.” What umami can do for you, and four foods to help you get there 2016-09-14T04:00:00Z This technique is precise enough to detect the signalling molecule glutamate in a single gap between two neurons, thus revealing the exact cells involved3. Brain's chemical signals seen in real time 2016-08-21T04:00:00Z Many people think ketamine affects the action of a common neurotransmitter called glutamate, by blocking the activity of receptors for this molecule. Novel drugs for depression 2016-10-13T04:00:00Z Baker and his students, including senior graduate student Evan Hess, want to challenge the dogma that the critical communication within the brain, particularly by glutamate, only occurs within the synapse. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Ketamine acts on the brain’s glutamate receptors, which are involved in learning and memory. Researchers Study New Ways to Treat Suicide Risk 2016-06-20T04:00:00Z Rapid growth, especially in the past decade, has debased much restaurant cooking, drowning the tastes and textures of dishes like fish-fragrant eggplant in gobs of acrid chili, oil and monosodium glutamate. Sichuan cuisine: A culinary heritage in crisis 2016-06-20T04:00:00Z Reports of worms and high levels of monosodium glutamate in Ramdev’s instant noodles sparked controversy last year after a food standards authority said the product never received its approval. Spirituality in a bottle: Indian guru builds empire on ‘holy’ bodywash for the faithful 2016-04-09T04:00:00Z Clinical trials tested two drugs thought to prevent excessive glutamate from overstimulating neurons; one normally is prescribed for amyotrophic lateral sclerosis and the other for Alzheimer’s disease. Beyond the catchphrase 2016-03-21T04:00:00Z Thus, most disorders of the brain involve some degree of glutamate dysfunction. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z When glutamate levels are high, the brain is stressed and doesn't work as well, the researchers explained in a university news release. Sleep Apnea May Take Toll on Your Mood, Thinking Skills 2016-02-29T05:00:00Z Last year, Nestle India’s popular instant noodles, called Maggi, faced a national scandal after local tests found monosodium glutamate and high lead levels in some samples. Guru Inc.: India’s holy men enter the world of big business 2016-02-26T05:00:00Z So the cooks began adding the powder to MSG, or monosodium glutamate, and put it in sauce used by customers. At Some Restaurants in China, a Shortcut to Addictive Food: Poppies 2016-01-30T05:00:00Z It is removing disodium inosinate and monosodium glutamate and eight other ingredients from two children's chicken soup varieties while adding flavors such as dehydrated chicken broth and onions. Campbell Soup's New Recipe: 6 Other Times Companies Tweaked Their Products 2015-12-16T05:00:00Z This chemical isn’t only released by neurons, but there are multiple ways in which the human brain releases glutamate. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z In the sea lion brain, domoic acid mimics a neurotransmitter called glutamate, eventually overwhelming and killing neurons in the hippocampus that use glutamate to talk with one another. Toxic Algae Causing Brain Damage, Memory Loss in Sea Lions 2015-12-14T05:00:00Z Maggi was also undergoing tests for high levels of monosodium glutamate or MSG, a common but harmful chemical ingredient used as a flavor enhancer in packaged and fast foods worldwide. Nestle Takes Maggi Instant Noodles Off Shelves Across India 2015-06-05T04:00:00Z The tests also detected the chemical flavour enhancer monosodium glutamate, or MSG, which is not mentioned in the product’s list of ingredients. India withdraws Maggi noodles from shops in mounting food-safety scare 2015-06-03T04:00:00Z The tests also detected the chemical flavor enhancer monosodium glutamate, or MSG, which is not mentioned in the product’s list of ingredients. Maggi noodles ordered off India’s shelves due to lead level 2015-06-03T04:00:00Z Baker’s research suggests that the brain has forms of glutamate signaling between cells that are needed for highly specialized forms of activity. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z Namenda works by increasing the level of glutamate in the brain and is thought to interfere with cell death. The Last Day of Her Life 2015-05-14T04:00:00Z According to the Umami Information Center, glutamate occurs naturally in meat, fish, vegetables and dairy products. You're not a lush. You crave airplane Bloody Marys for a reason 2015-05-14T04:00:00Z Neurons talk to each other through chemical messengers known as neurotransmitters–including dopamine, serotonin, glutamate and compounds called endocannabinoids–which in turn send instructions to your body about what to do. The Great Pot Experiment 0002-11-29T05:00:00Z MSG is metabolized to glutamate, an excitatory neurotransmitter in the brain, says Dr. Arthur. The Best and Worst Foods to Eat When You're Sick 2015-02-21T05:00:00Z Here he studied the links between compulsive drug seeking and glutamate release in rats. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z In the brain, when the psychoactive component THC links up with CB1, it slows down or blocks the release of a variety of neurotransmitters—signaling molecules released by neurons—including glutamate and dopamine. How Medical Marijuana’s Chemicals May Protect Cells 2015-01-29T05:00:00Z Ikeda’s ideas were also disputed by sceptical scientists, until the discovery of glutamate receptors both on the tongue and in the gut. The tastemakers 2015-01-29T05:00:00Z It is found in foods that contain high levels of glutamate, such as cured meats, shellfish, soy sauce, cheese and green tea, and other foods rich in protein. Umami taste buds 'key to health' 2015-01-25T05:00:00Z The team found that some nerve endings in the region secrete both glutamate and GABA. Depression Tweaks the Brain's Disappointment Circuit 2015-01-21T05:00:00Z To better understand the evolutionary expansion and divergence of glutamate signaling, Hess and his team are comparing the expression of the genetic sequence that codes for system xc- in 115 vertebrate species. Glutamate Built the Brain—Can It Treat It Too? 2020-01-13T05:00:00Z The second chemical is called glutamate, which can take a few days longer to be properly released. Why Some Antidepressants Make You Feel Worse Before Better 2014-12-17T05:00:00Z “This is important confirmatory evidence that glutamate is relevant to schizophrenia,” O'Donovan says. Massive Study Reveals Schizophrenia's Genetic Roots 2014-12-10T05:00:00Z It is believed to work mainly by blocking receptors in the brain for N-methyl-D-aspartate, or NMDA, which interact with a different neurotransmitter called glutamate. Special K, a Hallucinogen, Raises Hopes and Concerns as a Treatment for Depression 2014-12-09T05:00:00Z They also “receive less glutamate from yet different sources, ultimately triggering muscle movement in a different way,” Mentis says. First ALS Ice Bucket Funds Target Genes, Inflammation 2014-10-16T04:00:00Z It’s actually the fifth basic taste thanks to certain chemicals like glutamate and guanylate that occur naturally in food, according to the Umami Information Council. 5 Fascinating Things You Didn't Know About Mushrooms 2014-10-11T04:00:00Z He said measurements of glutamate, a neurotransmitter that surges in brain injury, showed that “the more severe the damage, the higher the spike” in glutamate. Scientists Create 3D Model That Mimics Brain Function 2014-08-11T04:00:00Z Some are involved in the activity of a second transmitter molecule, glutamate; others regulate the flow of calcium ions into cells. Some needles in the haystack 2014-07-22T04:00:00Z In the last 10 years, Eli Lilly & Co. attempted to target schizophrenia using another drug, one that targeted the brain transmitter glutamate. Schizophrenia Gene Study May Point to New Treatment 2014-07-21T04:00:00Z Sustained exposure to glutamate may cause an over-accumulation of calcium, which harms cells. First ALS Ice Bucket Funds Target Genes, Inflammation 2014-10-16T04:00:00Z Long used in Japanese cooking, umami is actually glutamate, once it’s broken down by cooking a steak, for example, or by fermenting things like cheese and soy. This Taste May Help With Weight Loss 2014-07-21T04:00:00Z The binding of glutamate to its receptor triggers the opening of specialized protein-based pores in the membrane known as ion channels, which allows positively charged calcium and sodium ions to flood into the responding cell. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z They explained that glutamate plays a significant role in certain brain functions, such as memory, learning, thinking, attention and behavior. Genetic 'Networks' May Play Role in Autism 2014-06-06T04:00:00Z It also appears to affect other chemicals in the brain, such as glutamate, that are responsible for creating high levels of neural activity. 7 reasons why the future of sleep could be wilder than your wildest dreams Every business trip ended with egg rolls and spareribs and enough monosodium glutamate to goon them all into an animate diorama of menu item No. 14: Happy Family. Sam Lipsyte: “The Naturals.” 2014-04-28T04:00:00Z The company has produced a drug that blocks glutaminase, the enzyme that converts glutamine to glutamate, a key step in the cycle. Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z However, activated astrocytes can also help to reduce seizure intensity: they contribute to the production of adenosine, a signalling molecule that can counter the effects of glutamate. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z The researchers also focused on a pathway involving a family of genes that affects the neurotransmitter glutamate. Genetic 'Networks' May Play Role in Autism 2014-06-06T04:00:00Z Larger dilations to glutamate in low O may reflect less production of 20-HETE from arachidonic acid. c, In ischaemia, the decrease of ATP concentration leads to a rise of Ca in pericytes. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z The authors found that pericytes relax their grip on capillaries in response to glutamate molecules, the key excitatory neurotransmitters in the brain. Vascular biology: Brain vessels squeezed to death 2014-04-04T18:23:16.270Z A few other drug companies are also pursuing different ways of modulating glutamate signalling to combat negative symptoms. Therapeutics: Negative feedback 2014-04-02T17:21:04.367Z This glutamate can in turn contribute to the excitation of adjacent neurons, and Carmignoto describes the formation of 'tripartite synapses' in which astrocytes actively participate in conversations once thought to occur exclusively between neurons. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z The study authors noted that larger studies are needed to investigate the genetics of autism, particularly the brain's glutamate signaling pathway. Genetic 'Networks' May Play Role in Autism 2014-06-06T04:00:00Z Larger dilations to glutamate in low O may reflect less production of 20-HETE from arachidonic acid. c, In ischaemia, the decrease of ATP concentration leads to a rise of Ca in pericytes. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z In vivo imaging with computed tomography and magnetic resonance imaging, and data from post-mortem studies in people with schizophrenia, pointed to cortical effects and implicated other neurotransmitter systems, such as glutamate and serotonin. Drug development: The modelling challenge 2014-04-02T17:21:02.740Z They tested 11 of the additives most commonly implicated in allergic reactions, including aspartame, monosodium glutamate, yellow dye No. 6, nitrites and nitrates. Well: Don’t Blame Food Additives for Hives 2014-03-21T10:00:49Z In short, adenosine turns down the neural signals that glutamate turns up, and that could reduce seizure activity, explains Carmignoto. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z Changes in other reward-system neurotransmitters such as glutamate can impair cognitive function. Animal farm 2014-02-05T18:20:00.450Z We demonstrate that neuronal activity and the neurotransmitter glutamate evoke the release of messengers that dilate capillaries by actively relaxing pericytes. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z Magnesium “sits” on the receptor without activating it, in effect protecting the receptor from over-activation by other neurochemicals, especially the neurotransmitter glutamate. Eat More Of These Four Things For A Stronger, Healthier Brain 2013-12-09T14:12:00Z Cleavage occurs between cysteine and glutamate residues and results in a pyroglutamate product. [Report] HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase 2013-12-05T18:57:21.053Z Instead of focusing on serotonin, norepinephrine or dopamine neurotransmitters, ketamine focuses on a glutamate neurotransmitter. Why Do Antidepressants Take So Long to Work? 2013-11-13T12:45:04.437Z Less glutamate leads to “a lower seizure risk and a better environment for neuronal recovery and repair.” Do Low Carbohydrate Diets Make You Dumber? 2013-11-12T16:54:00Z Extended Data Table 1: Properties of vessels of different branching orders in vivo Video 1: Noradrenaline constricts and glutamate dilates capillaries Vessel in Figure 1d responding to noradrenaline and glutamate in a rat cerebellar slice. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z When that happens, levels of the brain’s homegrown neuro-stimulants—dopamine and glutamate—increase, and we experience the brain stimulating effects associated with drinking a big cup of java. Will A Few Cups Of Coffee A Day Keep The Blues Away? 2013-07-28T21:39:00Z But excess glutamate triggers a cascade of worrisome activity. Understanding Alzheimer’s disease: Beta testing 2013-06-20T15:05:37Z But while the current drugs hit dopamine, serotonin, and norepinephrine, ketamine interacts with glutamate, the main excitatory neurotransmitter in the brain. Fighting Depression with Special K 2013-05-27T14:45:02.813Z This effect required dopamine neurons, and only dopamine neurons, influencing glutamate neurons in the same area had no effect. The dopamine side(s) of depression 2012-12-17T15:15:03.510Z These mechanisms resemble those controlling arteriole dilation, and may reflect glutamate release activating the production of arachidonic acid and its derivatives in astrocytes or neurons. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z Many researchers are also hopeful about clinical trials under way with drugs that block certain receptors for glutamate, the main neurotransmitter in the brain that excites neural activity. Diuretic Drug Offers Latest Hope for Autism Treatment 2012-12-11T09:00:00Z He then showed the effects of these higher glutamate levels. Understanding Alzheimer’s disease: Beta testing 2013-06-20T15:05:37Z These are, like glutamate, signaling chemicals between neurons. Fighting Depression with Special K 2013-05-27T14:45:02.813Z These included genes involved in the regulation of three neurotransmitters—dopamine, glutamate and serotonin—and also G-protein-coupled receptors, which react to a wide variety of stimulants. The genetics of politics: Body politic 2012-10-04T15:05:52Z This death is mediated in part by glutamate, but is not reduced by free radical scavenging, suggesting that the constriction and death differ at least partly in their causes. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z R Douglas Fields and colleagues published a paper last year showing that a neurotransmitter called glutamate, released along axons in response to electrical activity, increases myelination by stimulating production of myelin proteins in oligodendrocytes. The story of a lonely brain 2012-10-01T23:15:06.163Z The normal function of the neurotransmitter glutamate, the chemical overproduced in Huntington’s, is also intimately involved with learning. A Neurodegenerative Disease Improves Facets of Cognition 2012-09-28T17:15:07.867Z And umami, the savoury or meaty taste, is detected by a receptor for glutamate. Technology: The taste of things to come 2012-06-25T13:21:13.797Z For example, the glutamate receptor is a neuroreceptor in the human brain necessary for memory formation and learning. Do Plants Think? 2012-06-05T11:15:22.920Z Larger dilations to glutamate in low O may reflect less production of 20-HETE from arachidonic acid. c, In ischaemia, the decrease of ATP concentration leads to a rise of Ca in pericytes. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z This paper finds out a lot of detail about this feedback loop, including the use of glutamate as a neurotransmitter in one half of the loop. Clocks, metabolism, evolution - toward an integrative chronobiology 2012-05-30T12:45:00.197Z But on the other hand, it may augment a cognitive process that depends on glutamate transmission.” A Neurodegenerative Disease Improves Facets of Cognition 2012-09-28T17:15:07.867Z In a final set of experiments, the researchers showed that the calcium waves are generated by a neurotransmitter called glutamate, which is released from damaged cells. The Brain's Bat Signal 2012-05-24T18:40:00Z When the receptors were missing from neurons that produce the neurotransmitter glutamate, the mice displayed less anxiety, as expected. Mood Drug Can Both Cause and Relieve Anxiety 2012-04-11T13:15:00.207Z Video 1: Noradrenaline constricts and glutamate dilates capillaries Vessel in Figure 1d responding to noradrenaline and glutamate in a rat cerebellar slice. Capillary pericytes regulate cerebral blood flow in health and disease 2014-04-04T18:24:22.627Z As a consequence, the neurons begin absorbing another kind of glutamate receptor, called AMPA, which is a key process in the kind of long-term depression that eventually leads to impaired working memory. Structured Unlearning: Marijuana May Impair Memory via the Brain's Non-Firing Cells 2012-03-01T17:15:00.197Z Common ingredients like corn, vegetable oil, maltodextrin, soy protein, lecithin, monosodium glutamate, cornstarch, yeast extract, sugar and corn syrup are almost always produced from transgenic crops. A Suit Airs Debate on Organic vs. Modified Crops 2012-02-08T03:20:05Z Chief Executive Officer Indra Nooyi has added ”all- natural” labels to Lay’s chips and replaced ingredients like monosodium glutamate to attract consumers shying away from unhealthy snacks. PepsiCo Net Income Rises 18% as Frito-Lay Snack Sales Increase 2011-07-21T11:35:01Z A quick word about the yeast extract, which many of you may object to because of the high glutamate content. Recipes for Health: Edamame P?t? 2011-06-28T20:20:04Z And most of the resulting neurons communicated using a chemical called glutamate, limiting their use for understanding or treating diseases such as Parkinson's, which is characterized by problems in neurons that communicate with this chemical. Human Skin Cells Turned into Nerve Cells 2011-05-26T21:15:00.263Z "Can you smell smoke" I asked, as a new carbon rich malodorous scent began to mask the incumbent smell of over-used cooking oil mixed with mono-sodium glutamate. Let me entertain you 2011-03-28T06:00:03Z In those cells, the channel controls the release of a chemical called glutamate, which in turn sparks electrical communication with odor-processing centers in the brain. Who Felt It Not, Smelt It Not 2011-03-23T21:59:00Z Studies of certain psychomimetic substances in humans and animals suggest that disruption of excitatory signaling through glutamate receptors may be involved. [Editors' Choice] Excited to Madness 2011-01-19T22:55:26.410Z Ajinomoto, which began selling monosodium glutamate, or MSG, as a food flavoring a century ago, lost 30 percent of its market value in the five years ended in December as earnings fell. Ajinomoto May Raise Japan Prices as Costs Increase 2011-01-12T09:54:01Z As the creator of monosodium glutamate, a staple of fast food around the world, the Japanese company has been doing business overseas for decades. Special Report: Seven Samurai of new Japan Inc 2010-12-16T12:37:05Z The stage is set for post-traumatic stress disorder after a stressful event causes a natural flood of glutamate, a neurotransmitter that excites the neurons. Drug Prevents Post-Traumatic Stress Syndrome 2010-12-08T16:20:00Z GRIN2A is linked to glutamate, a compound that is suspected of killing the brain cells that die off in Parkinson's patients. Gene explains coffee's effects on Parkinson's: study 2010-09-29T19:59:00Z The results suggest that a buildup of that chemical, called glutamate, may play a role in the mechanism of migraines. Study finds first genetic link to common migraine 2010-08-29T17:04:00Z Another medication, Namenda, works to reduce the excessive amount of the neurotransmitter glutamate produced by Alzheimer's brains; too much glutamate results in cell death. Researchers hope to quell a surge of Alzheimer's cases with new diagnostic tools 2010-08-23T17:31:00Z Ketamine appears to work by "resetting" the way nerve cells process glutamate, a brain chemical key for learning, memory, and other functions, according to Zarate. Ketamine lifts mood quickly in bipolar disorder 2010-08-03T21:18:00Z The excess glutamate dissipates after 30 minutes, but the neurons remain frenzied. Drug Prevents Post-Traumatic Stress Syndrome 2010-12-08T16:20:00Z Ketamine dissociates patients from negative thoughts and feelings by preventing another neurotransmitter, glutamate, from interacting with a receptor in the brain that usually processes it. Is Ketamine a Quick Fix for Hard-to-Treat Depression? 2010-08-02T08:45:00Z Their research showed that it appears to regulate levels of glutamate, a chemical known as a neurotransmitter which transports messages between nerve cells in the brain. Study finds first genetic link to common migraine 2010-08-29T17:04:00Z MSG, or monosodium glutamate, appears to be a trigger for a number of individuals with migraine. Can Foods Trigger Migraines? 2010-07-26T15:02:00Z The gene, which exists in humans as well as in mice, appears to plays a role in the release and uptake of glutamate in the brain, a neurotransmitter that helps regulate urges. How an Obsessively Groomed Mouse Sheds Light on Obsessive-Compulsive Disorder 2010-04-29T05:15:00Z Hydrolyzed vegetable protein is widely used by food processors to boost flavor in ways similar to monosodium glutamate. FDA warns of salmonella risk from common flavor enhancer 2010-03-04T21:58:00Z Brain autopsies have suggested that glutamate activity is associated with bipolar disorder, and past studies have shown that severing the glutamate-receptor link can rapidly lift symptoms in people with major depression, within two hours. Is Ketamine a Quick Fix for Hard-to-Treat Depression? 2010-08-02T08:45:00Z Many moderns who have found that monosodium glutamate steps up the flavor of natural cheese, put it in at the start, using one-half teaspoon for each cup of grated Cheddar. The Complete Book of Cheese |
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