英语词汇“amyloid plaque”造句子简单的方法、技巧、例句及翻译-英语例句辞典

“We found evidence of quite extensive removal of amyloid plaque”, he says. Does our immune system hold the key to beating Alzheimer’s disease? 2019-03-03T05:00:00Z

The company said the drug had led to “rapid and robust amyloid plaque reduction” in the subjects’ brains and that the results supported its continuing research. Alzheimer's drug trials target older Californians. Do they understand what they're signing up for? 2023-07-10T04:00:00Z

“Imagine getting a blood test at age 50 or 60 and if you have amyloid plaque … we give you a drug,” Bateman said. Is it Alzheimer’s? Families want to know, and blood tests may offer answers. 2022-11-17T05:00:00Z

In the decision, the FDA used evidence from clinical trials that showed the drug reduced levels of amyloid plaque in the brain. The FDA is approving more drugs that haven’t been shown to work. Are patients being harmed? 2022-03-03T05:00:00Z

"Aduhelm was approved based on its demonstrated clinical effect in reducing amyloid plaque in the brain and the reasonable likelihood that removal of this plaque slows disease progression," company spokesperson Allison Parks told Salon. This one drug threatens to tank Medicare's entire prescription drug model 2021-12-04T05:00:00Z

Instead, it granted “accelerated approval” to the drug based on a “surrogate endpoint” — in this case, the drug’s ability to remove amyloid plaque from the brain. The controversial approval of an Alzheimer’s drug reignites the battle over the underlying cause of the disease 2021-07-05T04:00:00Z

Knopman said that while the data showed the drug reduced levels of amyloid plaque, scientists don’t know whether that leads to improvement in cognitive abilities. Alzheimer's drug trials target older Californians. Do they understand what they're signing up for? 2023-07-10T04:00:00Z

If microglia protect axons from amyloid plaque damage, might they also safeguard against tau pathology? Immune Cells Suggest New Alzheimer’s Treatment Possibilities 2021-07-26T04:00:00Z

The FDA granted the drug “accelerated approval” based on its effectiveness at removing amyloid plaque from the brain, which the agency said offered a reasonable likelihood that patients could benefit. FDA, facing intense criticism, narrows use of controversial Alzheimer’s drug to patients with early-stage disease 2021-07-08T04:00:00Z

Ultimately, there is no compelling evidence of a relationship between amyloid plaque and cognitive decline, nor evidence that depleting amyloid plaque slows the progression of Alzheimer’s disease. Opinion | The FDA approval for an Alzheimer’s treatment 2021-06-29T04:00:00Z

But unlike aducanumab, these prior drugs did not substantively lower amyloid plaque. Opinion | Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z

There were “multiple trials showing a significant reduction in amyloid plaque in the brain.” Furor rages over FDA approval of controversial Alzheimer’s drug 2021-06-17T04:00:00Z

Aducanumab is an antibody designed to remove amyloid plaque from the brain, but only one of two large-scale trials showed that it significantly slowed progression of the disease. Investors, patients await FDA decision on Biogen Alzheimer's drug due Monday 2021-06-04T04:00:00Z

The trials show the Biogen drug eliminates amyloid plaque — the debate is whether that improves patients’ cognitive abilities. Alzheimer’s drug sparks emotional battle as FDA nears deadline on whether to approve 2021-05-31T04:00:00Z

There have been several prior clinical trials of medications that reduce or eliminate amyloid plaque in Alzheimer’s patients that showed neither improvement in nor slowing of cognitive decline. Opinion | The FDA approval for an Alzheimer’s treatment 2021-06-29T04:00:00Z

While aducanumab’s trials suggested — but did not confirm — clinical benefit, they did convincingly and consistently show that the drug reduces amyloid plaque in the brain, a defining pathological characteristic of Alzheimer’s disease. Opinion | Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z

Biogen stopped a clinical trial in March that was the latest stunning collapse for experimental amyloid plaque drugs, sending the company’s stock plunging more than 29 percent. Alzheimer’s research is getting a reboot at small companies focused on the immune system 2019-07-03T04:00:00Z

New evidence indicates that the Y chromosome participates in an array of essential, general-interest tasks in men, like stanching cancerous growth, keeping arteries clear and blocking the buildup of amyloid plaque in the brain. Secrets of the Y Chromosome 2018-06-11T04:00:00Z

Wednesday’s findings mark a first peek at a huge study to determine whether Medicare should pay for specialized PET scans searching for an Alzheimer’s hallmark — sticky amyloid plaque. Brain scans may change care for some people with memory loss 2017-07-19T04:00:00Z

The lead author, Dr. Rebecca F. Gottesman, an associate professor of neurology at Johns Hopkins, said that amyloid plaque is one factor in Alzheimer’s disease, but not the only one. Heart Risks in Midlife Tied to Brain Plaques of Alzheimer’s 2017-04-12T04:00:00Z

Newer drugs that are being developed for Alzheimer’s have reported reduction in amyloid plaque with slowing of the progression of the disease. Opinion | Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z

Researchers now think that for people who eventually develop Alzheimer’s, deposits of amyloid plaque may begin to build up as early as 10 to 20 years before the first signs of memory loss. University of Kansas conducts dementia research 2016-12-02T05:00:00Z

In the trial, the strongest glimpse of mental improvement was seen in patients who had the highest dose of drug and who showed the greatest reduction in amyloid plaque proteins in follow-up brain scans. Trial shows tantalising signs that new Alzheimer's drug could benefit early-stage patients 2016-08-31T04:00:00Z

Indeed, researchers detected patterns in the retinas – through changes in light reflection as early stages of amyloid plaque gathered – that signified the disease's progression. Health Buzz: A Simple Eye Test Could Help Diagnose Alzheimer's Disease 2016-07-12T04:00:00Z

"Additional research needs to be done to understand these long-term processes, such as amyloid plaque deposition and persistent brain inflammation, and of course to develop treatments that target these processes," he added. Head Injuries Tied to Buildup of Alzheimer's Plaques, Small Study Finds 2016-02-03T05:00:00Z

Brain scans measured amyloid plaque levels in their brains, with 48 percent registering a level often associated with dementia. Slowed Walking in Seniors May Signal Alzheimer's Danger 2015-12-02T05:00:00Z

Dr. Sam Gandy, director of the Center for Cognitive Health at Mount Sinai Hospital in New York City, said that mental function is far more important than amyloid plaque in the brain. Exercise, Games, Puzzles Don't Prevent Signs of Alzheimer's in the Brain: Study 2015-06-10T04:00:00Z

It marks the first time an experimental drug demonstrated both a statistically significant reduction in amyloid plaque and a slowing of clinical impairment in patients with mild disease, said Alfred Sandrock, Biogen's chief medical officer. Alzheimer's Drug Slows Mental Decline in Early Study 2015-03-20T04:00:00Z

This disrupts the "blood-brain barrier," which protects the brain from germs in the blood, Leinenga said, apparently allowing molecules to enter the brain and activate cells that "eat" amyloid plaque. Ultrasound Used to Attack Alzheimer's-Linked Brain Plaque in Mice 2015-03-11T04:00:00Z

However, in the brain neprilysin appears to play a key role in degrading the beta amyloid plaque that is one of the hallmarks of Alzheimer’s disease. New Heart Drug From Novartis: Will It Raise The Risk of Alzheimer's Disease? 2015-02-09T05:00:00Z

“Vitamin D helps to prevent the accumulation of the toxic amyloid plaque that is present in Alzheimer’s disease and prevents vascular brain disease.” Dementia Risk And Vitamin D Levels: Is There A Connection? 2014-08-07T04:00:00Z

Not everyone who has an excessive amount of amyloid plaque develops Alzheimer's, and at the moment, there is generally no way to predict whom the unlucky ones will be. How Brain Scans Might Change the Way Doctors Diagnose Alzheimer s 2013-12-10T12:15:00.460Z

According to the National Institute on Aging, it is not yet known whether amyloid plaque causes the disease or is a byproduct of it. Seniors who don’t sleep well have higher levels of an Alzheimer’s biomarker, study says 2013-10-28T20:11:11Z

The technique appeared to reduce levels of amyloid plaque in the treated mice and nearly eliminate it in 75 percent of the animals -- without damaging brain tissue. Ultrasound Used to Attack Alzheimer's-Linked Brain Plaque in Mice 2015-03-11T04:00:00Z

"I think the amyloid plaque hypothesis is the best shot we've got," the CEO said. Eli Lilly CEO says company keeping animal health business 2013-02-11T21:33:33Z

Most longitudinal studies into ageing focus on dementias such as Alzheimer's disease, which is associated with deposits of amyloid plaque and tangles of tau protein in the brain. Cognition: The brain's decline 2012-12-06T12:20:59.970Z

As I mentioned in my first set of answers, a new PET scan to detect amyloid plaque in the brain was approved by the F.D.A. this year. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z

In fact, some researchers think these changes might be a sign the drug is working to clear the amyloid plaque. Last drugs standing: Key Alzheimer results coming 2012-07-11T16:57:26Z

Lilly's latest contender, solanezumab, is designed to bind to and mop up a protein called amyloid beta, the main component of amyloid plaque deposits in the brains of patients with Alzheimer's disease. Lilly Alzheimer's drug an unlikely ace in the hole 2012-02-01T23:29:15Z

The hope is that by using experimental drugs, growth of this amyloid plaque will be inhibited before the illness strikes. Flawed gene 2011-05-19T00:53:08Z

The test, a type of PET scan developed by Avid Radiopharmaceuticals, is designed to detect the telltale buildups of amyloid plaque in the brain that signify Alzheimer's disease. Mixed Messages on Alzheimer's Test 2011-01-21T21:21:55Z

Animal studies show a link between saturated fats and brain amyloid plaque buildup. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z

The work opens an important window into the neurobiology of Alzheimer's, but doesn't negate the long-standing focus on amyloid plaque, cautions dementia specialist Dr. Paul Aisen of the University of California, San Diego. Alzheimer's brain tangles offer clue to worsening 2010-09-20T20:31:00Z

There also is a different group of experimental Alzheimer’s therapies that use antibodies to attack amyloid plaque. What to Tell the Patients After a Trial Goes Awry 2010-08-23T19:39:00Z

Rinne and colleagues used a novel imaging substance called carbon-11-labeled Pittsburgh compound B, which sticks to areas of the brain where there is a lot of beta amyloid plaque. Brain images suggest Alzheimer's drug is working 2010-03-01T00:08:00Z

单词	amyloid plaque
例句	amyloid plaque “We found evidence of quite extensive removal of amyloid plaque”, he says. Does our immune system hold the key to beating Alzheimer’s disease? 2019-03-03T05:00:00Z The company said the drug had led to “rapid and robust amyloid plaque reduction” in the subjects’ brains and that the results supported its continuing research. Alzheimer's drug trials target older Californians. Do they understand what they're signing up for? 2023-07-10T04:00:00Z “Imagine getting a blood test at age 50 or 60 and if you have amyloid plaque … we give you a drug,” Bateman said. Is it Alzheimer’s? Families want to know, and blood tests may offer answers. 2022-11-17T05:00:00Z In the decision, the FDA used evidence from clinical trials that showed the drug reduced levels of amyloid plaque in the brain. The FDA is approving more drugs that haven’t been shown to work. Are patients being harmed? 2022-03-03T05:00:00Z "Aduhelm was approved based on its demonstrated clinical effect in reducing amyloid plaque in the brain and the reasonable likelihood that removal of this plaque slows disease progression," company spokesperson Allison Parks told Salon. This one drug threatens to tank Medicare's entire prescription drug model 2021-12-04T05:00:00Z Instead, it granted “accelerated approval” to the drug based on a “surrogate endpoint” — in this case, the drug’s ability to remove amyloid plaque from the brain. The controversial approval of an Alzheimer’s drug reignites the battle over the underlying cause of the disease 2021-07-05T04:00:00Z Knopman said that while the data showed the drug reduced levels of amyloid plaque, scientists don’t know whether that leads to improvement in cognitive abilities. Alzheimer's drug trials target older Californians. Do they understand what they're signing up for? 2023-07-10T04:00:00Z If microglia protect axons from amyloid plaque damage, might they also safeguard against tau pathology? Immune Cells Suggest New Alzheimer’s Treatment Possibilities 2021-07-26T04:00:00Z The FDA granted the drug “accelerated approval” based on its effectiveness at removing amyloid plaque from the brain, which the agency said offered a reasonable likelihood that patients could benefit. FDA, facing intense criticism, narrows use of controversial Alzheimer’s drug to patients with early-stage disease 2021-07-08T04:00:00Z Ultimately, there is no compelling evidence of a relationship between amyloid plaque and cognitive decline, nor evidence that depleting amyloid plaque slows the progression of Alzheimer’s disease. Opinion \| The FDA approval for an Alzheimer’s treatment 2021-06-29T04:00:00Z But unlike aducanumab, these prior drugs did not substantively lower amyloid plaque. Opinion \| Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z There were “multiple trials showing a significant reduction in amyloid plaque in the brain.” Furor rages over FDA approval of controversial Alzheimer’s drug 2021-06-17T04:00:00Z Aducanumab is an antibody designed to remove amyloid plaque from the brain, but only one of two large-scale trials showed that it significantly slowed progression of the disease. Investors, patients await FDA decision on Biogen Alzheimer's drug due Monday 2021-06-04T04:00:00Z The trials show the Biogen drug eliminates amyloid plaque — the debate is whether that improves patients’ cognitive abilities. Alzheimer’s drug sparks emotional battle as FDA nears deadline on whether to approve 2021-05-31T04:00:00Z There have been several prior clinical trials of medications that reduce or eliminate amyloid plaque in Alzheimer’s patients that showed neither improvement in nor slowing of cognitive decline. Opinion \| The FDA approval for an Alzheimer’s treatment 2021-06-29T04:00:00Z While aducanumab’s trials suggested — but did not confirm — clinical benefit, they did convincingly and consistently show that the drug reduces amyloid plaque in the brain, a defining pathological characteristic of Alzheimer’s disease. Opinion \| Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z Biogen stopped a clinical trial in March that was the latest stunning collapse for experimental amyloid plaque drugs, sending the company’s stock plunging more than 29 percent. Alzheimer’s research is getting a reboot at small companies focused on the immune system 2019-07-03T04:00:00Z New evidence indicates that the Y chromosome participates in an array of essential, general-interest tasks in men, like stanching cancerous growth, keeping arteries clear and blocking the buildup of amyloid plaque in the brain. Secrets of the Y Chromosome 2018-06-11T04:00:00Z Wednesday’s findings mark a first peek at a huge study to determine whether Medicare should pay for specialized PET scans searching for an Alzheimer’s hallmark — sticky amyloid plaque. Brain scans may change care for some people with memory loss 2017-07-19T04:00:00Z The lead author, Dr. Rebecca F. Gottesman, an associate professor of neurology at Johns Hopkins, said that amyloid plaque is one factor in Alzheimer’s disease, but not the only one. Heart Risks in Midlife Tied to Brain Plaques of Alzheimer’s 2017-04-12T04:00:00Z Newer drugs that are being developed for Alzheimer’s have reported reduction in amyloid plaque with slowing of the progression of the disease. Opinion \| Here’s why we approved the first new Alzheimer’s drug in two decades 2021-06-23T04:00:00Z Researchers now think that for people who eventually develop Alzheimer’s, deposits of amyloid plaque may begin to build up as early as 10 to 20 years before the first signs of memory loss. University of Kansas conducts dementia research 2016-12-02T05:00:00Z In the trial, the strongest glimpse of mental improvement was seen in patients who had the highest dose of drug and who showed the greatest reduction in amyloid plaque proteins in follow-up brain scans. Trial shows tantalising signs that new Alzheimer's drug could benefit early-stage patients 2016-08-31T04:00:00Z Indeed, researchers detected patterns in the retinas – through changes in light reflection as early stages of amyloid plaque gathered – that signified the disease's progression. Health Buzz: A Simple Eye Test Could Help Diagnose Alzheimer's Disease 2016-07-12T04:00:00Z "Additional research needs to be done to understand these long-term processes, such as amyloid plaque deposition and persistent brain inflammation, and of course to develop treatments that target these processes," he added. Head Injuries Tied to Buildup of Alzheimer's Plaques, Small Study Finds 2016-02-03T05:00:00Z Brain scans measured amyloid plaque levels in their brains, with 48 percent registering a level often associated with dementia. Slowed Walking in Seniors May Signal Alzheimer's Danger 2015-12-02T05:00:00Z Dr. Sam Gandy, director of the Center for Cognitive Health at Mount Sinai Hospital in New York City, said that mental function is far more important than amyloid plaque in the brain. Exercise, Games, Puzzles Don't Prevent Signs of Alzheimer's in the Brain: Study 2015-06-10T04:00:00Z It marks the first time an experimental drug demonstrated both a statistically significant reduction in amyloid plaque and a slowing of clinical impairment in patients with mild disease, said Alfred Sandrock, Biogen's chief medical officer. Alzheimer's Drug Slows Mental Decline in Early Study 2015-03-20T04:00:00Z This disrupts the "blood-brain barrier," which protects the brain from germs in the blood, Leinenga said, apparently allowing molecules to enter the brain and activate cells that "eat" amyloid plaque. Ultrasound Used to Attack Alzheimer's-Linked Brain Plaque in Mice 2015-03-11T04:00:00Z However, in the brain neprilysin appears to play a key role in degrading the beta amyloid plaque that is one of the hallmarks of Alzheimer’s disease. New Heart Drug From Novartis: Will It Raise The Risk of Alzheimer's Disease? 2015-02-09T05:00:00Z “Vitamin D helps to prevent the accumulation of the toxic amyloid plaque that is present in Alzheimer’s disease and prevents vascular brain disease.” Dementia Risk And Vitamin D Levels: Is There A Connection? 2014-08-07T04:00:00Z Not everyone who has an excessive amount of amyloid plaque develops Alzheimer's, and at the moment, there is generally no way to predict whom the unlucky ones will be. How Brain Scans Might Change the Way Doctors Diagnose Alzheimer s 2013-12-10T12:15:00.460Z According to the National Institute on Aging, it is not yet known whether amyloid plaque causes the disease or is a byproduct of it. Seniors who don’t sleep well have higher levels of an Alzheimer’s biomarker, study says 2013-10-28T20:11:11Z The technique appeared to reduce levels of amyloid plaque in the treated mice and nearly eliminate it in 75 percent of the animals -- without damaging brain tissue. Ultrasound Used to Attack Alzheimer's-Linked Brain Plaque in Mice 2015-03-11T04:00:00Z "I think the amyloid plaque hypothesis is the best shot we've got," the CEO said. Eli Lilly CEO says company keeping animal health business 2013-02-11T21:33:33Z Most longitudinal studies into ageing focus on dementias such as Alzheimer's disease, which is associated with deposits of amyloid plaque and tangles of tau protein in the brain. Cognition: The brain's decline 2012-12-06T12:20:59.970Z As I mentioned in my first set of answers, a new PET scan to detect amyloid plaque in the brain was approved by the F.D.A. this year. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z In fact, some researchers think these changes might be a sign the drug is working to clear the amyloid plaque. Last drugs standing: Key Alzheimer results coming 2012-07-11T16:57:26Z Lilly's latest contender, solanezumab, is designed to bind to and mop up a protein called amyloid beta, the main component of amyloid plaque deposits in the brains of patients with Alzheimer's disease. Lilly Alzheimer's drug an unlikely ace in the hole 2012-02-01T23:29:15Z The hope is that by using experimental drugs, growth of this amyloid plaque will be inhibited before the illness strikes. Flawed gene 2011-05-19T00:53:08Z The test, a type of PET scan developed by Avid Radiopharmaceuticals, is designed to detect the telltale buildups of amyloid plaque in the brain that signify Alzheimer's disease. Mixed Messages on Alzheimer's Test 2011-01-21T21:21:55Z Animal studies show a link between saturated fats and brain amyloid plaque buildup. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z The work opens an important window into the neurobiology of Alzheimer's, but doesn't negate the long-standing focus on amyloid plaque, cautions dementia specialist Dr. Paul Aisen of the University of California, San Diego. Alzheimer's brain tangles offer clue to worsening 2010-09-20T20:31:00Z There also is a different group of experimental Alzheimer’s therapies that use antibodies to attack amyloid plaque. What to Tell the Patients After a Trial Goes Awry 2010-08-23T19:39:00Z Rinne and colleagues used a novel imaging substance called carbon-11-labeled Pittsburgh compound B, which sticks to areas of the brain where there is a lot of beta amyloid plaque. Brain images suggest Alzheimer's drug is working 2010-03-01T00:08:00Z
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