英语词汇“fibroblast”造句子简单的方法、技巧、例句及翻译-英语例句辞典

When combined with a dynamic magnetic field generated by an external device, the mechanical stimulation of the gel encourages dermal fibroblasts to become more active. NUS scientists develop innovative magnetic gel that heals diabetic wounds three times faster 2023-10-19T04:00:00Z

As illustrated in Figure 1, loose connective tissue has some fibroblasts; macrophages are present as well. Fundamentals of Biology 2015-01-01T00:00:00Z

Interestingly, humans and chimpanzees express USP14 at distinct levels in specific cell types, including cortical cells and fibroblasts. Biology for AP Courses 2022-06-09T00:00:00Z

These modified fibroblasts may be able to replace embryonic stem cells, potentially solving the ethical problems. Miller & Levine Biology 2018-01-01T00:00:00Z

Polysaccharides and proteins secreted by fibroblasts combine with extra-cellular fluids to produce a viscous ground substance that, with embedded fibrous proteins, forms the extra-cellular matrix. Anatomy and Physiology 2013-06-19T00:00:00Z

Working with mice and with human skin samples, the scientists found that C. acnes triggers fibroblasts to transform into fat cells that secrete an antimicrobial substance—along with inflammation-causing proteins. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z

Interspersed among the collagen fibers are long, thin fibroblasts. Fundamentals of Biology 2015-01-01T00:00:00Z

As illustrated in Figure 24.12, loose connective tissue has some fibroblasts; macrophages are present as well. Biology for AP Courses 2022-06-09T00:00:00Z

Skin cells are very good for this endeavour, particularly a type of connective tissue cell called a fibroblast. Extinction: Why scientists are freezing threatened species in 'biobanks' 2022-05-19T04:00:00Z

As you might expect, a fibrocyte, a less active form of fibroblast, is the second most common cell type in connective tissue proper. Anatomy and Physiology 2013-06-19T00:00:00Z

The researchers also discovered that retinoids, a powerful and commonly used class of pimple-fighting drug, work partially by blocking fibroblasts' transformation and release of irritating proteins. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z

Adipose tissue, or fat tissue, is considered a connective tissue even though it does not have fibroblasts or a real matrix and only has a few fibers. Fundamentals of Biology 2015-01-01T00:00:00Z

Though fragments of the blood clot may remain, fibroblasts and osteoblasts enter the area and begin to reform bone. Biology for AP Courses 2022-06-09T00:00:00Z

Fusing a ferret fibroblast with an egg cell made an embryo, and a clone - Elizabeth Ann the black-footed ferret - was born in December of 2020. Extinction: Why scientists are freezing threatened species in 'biobanks' 2022-05-19T04:00:00Z

Secreted by fibroblasts, ground substance is made of polysaccharides, specifically hyaluronic acid, and proteins. Anatomy and Physiology 2013-06-19T00:00:00Z

Because retinoids can have undesirable side effects, she says, pursuing a more targeted way to stop the fibroblasts' transformation would be “fantastic” for clinical treatment. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z

Neutrophils release substances that activate fibroblasts to begin to repair the area. Fundamentals of Biology 2015-01-01T00:00:00Z

The principal cell of connective tissues is the fibroblast. Biology for AP Courses 2022-06-09T00:00:00Z

Just like T cells engineered outside the body in traditional CAR-T therapy, they use the mRNA instructions to become primed to target and kill the fibroblast cells displaying FAP. Cutting-edge cancer and COVID-19 approaches could reduce organ scarring 2022-01-05T05:00:00Z

As healing progresses, fibroblasts from the surrounding connective tissues replace the collagen and extracellular material lost by the injury. Anatomy and Physiology 2013-06-19T00:00:00Z

The organoids are about 2 millimeters in diameter and include the main types of cells typically present in this stage of development: cardiomyocytes, epithelial cells, fibroblasts, and epicardium. Lab-grown minihearts beat like the real thing 2021-05-20T04:00:00Z

The tear in the layers of skin prompts a type of skin cell — fibroblasts — to create collagen ropes and initiates a chain reaction of molecular events inside the skin cells. Imagine, Surgery Without a Scar 2021-04-22T04:00:00Z

The fibers and other components of the connective tissue matrix are secreted by fibroblasts. Biology for AP Courses 2022-06-09T00:00:00Z

In 2019, Epstein and his colleagues described success in applying the approach to fibrosis, with the goal of targeting connective tissue cells called fibroblasts that lay down excess scar tissue in the heart. Cutting-edge cancer and COVID-19 approaches could reduce organ scarring 2022-01-05T05:00:00Z

Figure 4.21 Tissue Healing During wound repair, collagen fibers are laid down randomly by fibroblasts that move into repair the area. Anatomy and Physiology 2013-06-19T00:00:00Z

They saw that cardiac fibroblasts, a type of cell responsible for maintaining tissue structure, migrated to the damaged areas to repair the dead cells, just as in babies that experience heart attacks. Lab-grown minihearts beat like the real thing 2021-05-20T04:00:00Z

We also took skin fibroblasts, which are known to divide and grow, and overexpressed nerve growth factors and then inserted them into the hippocampus. Neuroscientist’s research helped unearth how human brains can make new cells 2021-02-05T05:00:00Z

Skin cells known as fibroblasts are a common starting point because they are easy to collect, but they are hard to reprogram in some species. A menagerie of stem-cell models 2020-09-21T04:00:00Z

They found that gene-expression changes were more evident in fibroblasts and endothelial cells than in epithelial cells. An antiviral response beyond immune cells 2020-06-30T04:00:00Z

The repair phase includes blood clotting, followed by regeneration of tissue as fibroblasts deposit collagen. Anatomy and Physiology 2013-06-19T00:00:00Z

“The fibroblasts in the dermis layer respond to that light and start acting as collagen factories again, growing new collagen,” says Pederson. Can LED light therapy turn back your skin’s clock? | Provided by RenewAlliance 2020-06-30T04:00:00Z

In addition, fibroblast cells in the tumour microenvironment secrete material that generates a physical barrier hindering the influx of T cells to the tumour site6. Pancreatic cancer hidden in plain sight 2020-04-21T04:00:00Z

Human and mouse iPS cells are usually round and form tightly packed colonies, unlike the original fibroblasts, which tend to be flatter and generate sprawling cultures. A menagerie of stem-cell models 2020-09-21T04:00:00Z

The year after the paper’s publication, human fibroblasts were directly converted into neurons10, although this required more transcription factors than were needed for the conversion of mouse cells. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z

Interstitial fibroblasts within the kidney secrete EPO, thereby increasing erythrocyte production and restoring oxygen levels. Anatomy and Physiology 2013-06-19T00:00:00Z

Asp et al. demonstrated that these fibroblast subgroups are located in distinct parts of the heart, providing a clue as to how they might function differently. Techniques converge to map the developing human heart at single-cell level 2020-01-26T05:00:00Z

Given that fibroblasts regulate the extracellular matrix, the authors used microscopy to visualize physical features of fibres of the protein collagen, which is a component of the extracellular matrix. Ready-made cellular plugs heal skin wounds 2019-11-26T05:00:00Z

Ward, whose children are 8, 7 and 4, said she paid nearly $500 for a procedure called fibroblast last November. Stretch mark removal procedure leaves mom with infected scars 2019-09-30T04:00:00Z

The first example4 was the conversion of fibroblasts into muscle cells by inducing the cells to express the transcription factor MyoD. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z

Before the basal stem cells of the stratum basale can recreate the epidermis, fibroblasts mobilize and divide rapidly to repair the damaged tissue by collagen deposition, forming granulation tissue. Anatomy and Physiology 2013-06-19T00:00:00Z

But, she cautioned, there are several potential concerns for any therapy that attacks fibroblasts. This Treatment Can Cure Cancer. Can It Mend the Heart? 2019-09-11T04:00:00Z

This barrier is formed in the lining layer, adjacent to a layer of cells called fibroblasts. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z

These fibroblasts express the protein FAPα and are associated with bone and cartilage destruction. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

All of a sudden, fibroblasts — which are relatively easy to isolate from mouse embryos and are easy to grow in vitro — could be converted into a cell type of great therapeutic interest. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z

Blood capillaries follow the fibroblasts and help increase blood circulation and oxygen supply to the area. Anatomy and Physiology 2013-06-19T00:00:00Z

The group found one, fibroblast activation protein, or FAP, by looking through a large genetic database. This Treatment Can Cure Cancer. Can It Mend the Heart? 2019-09-11T04:00:00Z

When arthritis was induced, the layer underwent active remodelling that loosened the physical interactions between barrier macrophages and lining-layer fibroblasts. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z

To assess the functional role of the fibroblasts, the authors used their mouse model of arthritis5 to deplete fibroblasts during the initiation and maintenance phases of the disease. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

“The majority could be fibroblasts”—connective-tissue cells—“or other unhelpful cells.” The Birth-Tissue Profiteers 2019-05-07T04:00:00Z

Cytokines are glycoproteins secreted by a wide variety of cells, including red bone marrow, leukocytes, macrophages, fibroblasts, and endothelial cells. Anatomy and Physiology 2013-06-19T00:00:00Z

Bursac has recently woven in more complexity, adding populations of endothelial cells, which develop into blood vessels, and fibroblast cells, which he realized can help the patch form and become stronger. Lab-grown patch of heart muscle and other cells could fix ailing hearts 2019-04-24T04:00:00Z

The challenge that lies ahead will be to develop ways of specifically targeting subsets of macrophages and fibroblasts with the ultimate goal of developing new treatments for people with arthritis. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z

The depletion of all FAPα-expressing fibroblasts led to a substantial reduction in the number of cells in the synovial membrane, suggesting a general reduction in inflammation. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

The authors report that the protein IL-6, which is synthesized in non-cancerous fibroblast cells adjacent to a pancreatic cancer, is a key driver of tumour invasion of the liver. Molecular envoys pave the way for pancreatic cancer to invade the liver 2019-03-05T05:00:00Z

Dr. Akil and colleagues at the Pritzker Neuropsychiatric Disorders Research Consortium found that one growth factor that is depleted in depressed brains, called fibroblast growth factor 2, also plays a role in resilience. Opinion | How to Be More Resilient 2018-12-15T05:00:00Z

It also increases proliferation and migration of fibroblasts, the cells responsible for collagen production, and regulates signalling pathways related to inflammation, aiding wound healing. The edible skincare diet 2018-11-20T05:00:00Z

When they created a wound on the back, they found that only one of two lineages of fibroblast — expressing homeobox protein engrailed-1 — was responsible for the formation of most scar tissue. Unlocking the secrets of scar-free skin healing 2018-11-20T05:00:00Z

This protection from disease progression correlated with a loss of both fibroblast populations, but not with a loss of pericytes, a type of fibroblast found associated with blood vessels. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

Meanwhile, connective tissue cells called fibroblasts carry positional information that’s crucial for regrowing a limb. Salamander's Genome Guards Secrets of Limb Regrowth 2018-07-07T04:00:00Z

Using methods that start with tissue cells called fibroblasts, researchers can engineer stem cells, which are cells capable of becoming any kind of body cell. Northern White Rhinos Are About to Die Out. Should We Save Them? 2018-03-13T04:00:00Z

For years, researchers suspected that tattoos worked by permanently staining fibroblasts, the cells that synthesize collagen, under the surface of our skin. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z

But the cells usually used to make these clones—connective tissue cells called fibroblasts—are short-lived, Cibelli notes, and can only divide 20 or 30 times. First cow embryonic stem cells could lead to healthier, more productive livestock 2018-02-05T05:00:00Z

To test the individual contributions of the two fibroblast populations directly, the authors isolated cells that either expressed or lacked Thy-1, and injected them into the inflamed joints of arthritic mice. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

They say the affect of the body clock on skin cells called fibroblasts is responsible for the difference. News Daily: May's Patel replacement and best injury times 2017-11-09T05:00:00Z

Detailed lab work showed skin cells called fibroblasts were changing their abilities in a 24-hour pattern. Daytime wounds 'heal more quickly' 2017-11-08T05:00:00Z

These cellular contractors tell fibroblasts to move into an injury to begin the healing process. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z

Despite recent success in directly reprogramming fibroblasts into various cell types, the precise changes that occur as fibroblasts progressively convert to the target cell fates remain unclear. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte 2017-10-24T04:00:00Z

Mice that received Thy-1-expressing fibroblasts developed more-severe inflammatory arthritis, but not greater bone or cartilage destruction than was the case for animals that did not receive a cellular transplant. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

Total RNA was prepared from untreated and IFN-treated mouse embryonic fibroblasts in a similar way. Dynamic landscape and regulation of RNA editing in mammals : Nature : Nature Research 2017-10-10T04:00:00Z

In animal skins both the synthesis of the initial amino-acid chains and their subsequent winding into fibres are done by special cells called fibroblasts. Leather grown using biotechnology is about to hit the catwalk 2017-08-24T04:00:00Z

The fibroblasts filled in scratches more quickly during the day than at night. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z

Detailed functional analysis of the top candidate splicing factor, Ptbp1, revealed that it is a critical barrier for the acquisition of cardiomyocyte-specific splicing patterns in fibroblasts. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte 2017-10-24T04:00:00Z

These exciting findings raise the possibility that clinical strategies might be developed for the selective depletion, targeted replacement or functional conversion of fibroblast subpopulations. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

The researchers mapped the PERVs interwoven into the genome of pig connective tissue cells, called fibroblasts. How turning off viruses in piglets could make their organs safer for people 2017-08-10T04:00:00Z

The fibroblasts produce a molecule called collagen 12, which changes the structure of the support matrix that surrounds nerve fibres. Scientists hope fish clues aid spinal cord injury treatment - BBC News 2017-07-25T04:00:00Z

Given the fibroblasts’ time-keeping abilities, O’Neill and colleagues searched for proteins within the cells that ebb and flow with daily rhythms. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z

This yielded two subgroups of fibroblasts — one that sits next to and interacts with the cancer cells, and another that is located farther away and produces tumour-boosting inflammatory molecules. Cancer: Tumours live in diverse areas : Nature : Nature Research 2017-03-07T05:00:00Z

Cells called fibroblasts contribute to the development of rheumatoid arthritis2, a condition characterized by damage to the joints that is marked by inflammation and the destruction of bone and cartilage. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z

The scientists have run a series of unpublished experiments to determine how much X-ray radiation is necessary to suppress fibroblast growth. Biologists struggle with push to eliminate radioactive caesium in labs 2016-05-09T04:00:00Z

Meanwhile, skin cells called dermal fibroblasts that normally produce collagen become less efficient at doing so. Cosmetics: Molecular beauty : Nature : Nature Publishing Group 2015-10-06T04:00:00Z

About twice as many fibroblasts migrated into the daytime wounds as nighttime ones. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z

Finally, fibroblasts rearrange collagen fibers to further strengthen the tissue that has closed over the wound. A better way to analyze how wounds are healing 2015-05-04T04:00:00Z

Working with mice, the team focused on two kinds of fibroblasts, which are cells responsible for maintaining the structural integrity of organs, tissues and more. The Strange Way a Diabetes Drug May Help Skin Scars 2015-04-16T04:00:00Z

But B lymphocytes will not divide unless they are activated — here, by the presence of connective-tissue cells called fibroblasts. Biologists struggle with push to eliminate radioactive caesium in labs 2016-05-09T04:00:00Z

These were then surrounded by other cell types, such as skin fibroblasts, which interact with these hepatocyte islands to help maintain liver-specific metabolic function and gene-activity profiles that would otherwise be lost. Artificial organs: Honey, I shrunk the lungs : Nature : Nature Publishing Group 2015-03-24T04:00:00Z

The researchers say that fibroblasts’ time-varying response may be an evolutionary adaptation. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z

Then, special cells called fibroblasts secrete a collagen scaffolding to allow new tissue to grow, filling in any skin gap left by the cut and promoting the growth of new blood vessels. A better way to analyze how wounds are healing 2015-05-04T04:00:00Z

When he treated the cells with diphtheria toxin, which destroys the fibroblasts, the animals scarred less. The Strange Way a Diabetes Drug May Help Skin Scars 2015-04-16T04:00:00Z

Notably, there appears to be a large expansion of the B compartment upon differentiation of human ES cells to MS cells or in IMR90 fibroblasts. Chromatin architecture reorganization during stem cell differentiation : Nature : Nature Publishing Group 2015-02-17T05:00:00Z

But the factors act differently when shoved into a differentiated cell such as a fibroblast. Stem cells: The black box of reprogramming 2014-12-09T05:00:00Z

The anti-malarial drug chloroquine causes some people to itch — especially people of African ancestry — and studying itch cells made from their fibroblasts could help to explain why, she adds. Pain and itch neurons grown in a dish 2014-11-24T05:00:00Z

Two others held suspensions of fibroblasts, the gristly cells that form the body’s connective tissue. How 3-D Printing Is Changing Medicine 2014-11-17T05:00:00Z

To assess the biological significance of the genetics, reprogramming human skin fibroblast cells into neurons and gene-editing technologies will be hugely useful. Mental health: Depression needs large human-genetics studies 2014-11-11T05:00:00Z

Typically, these cells are fibroblasts, the cells that make up the body’s connective tissue. For $100,000, You Can Clone Your Dog 2014-10-22T04:00:00Z

These ensure that only genes relevant for a fibroblast are expressed. Stem cells: The black box of reprogramming 2014-12-09T05:00:00Z

The machine works by placing two types of human cell - keratinocytes and fibroblasts - layer-by-layer into a hydrogel to create the desired patterns. Skin printer and bee probe win award 2014-09-17T04:00:00Z

The process began by taking connective tissue cells called fibroblasts from mouse embryos and "tweaking" their DNA to increase production of a protein called FOXN1. Scientists hail creation of working organ made from laboratory cells 2014-08-24T04:00:00Z

The second purification step was to isolate fibroblasts from the cell population by using CD10 beads for magnetic purification. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway 2014-04-04T18:28:18.449Z

He arranged for fibroblasts to be collected from the dog, which is currently working in Afghanistan and whose identity is classified. For $100,000, You Can Clone Your Dog 2014-10-22T04:00:00Z

Parental fibroblasts and aHeps were used as a negative and positive control, respectively. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

The technique was tested in fibroblasts to reveal the differences between individual cells during wound repair. [Report] Highly Multiplexed Subcellular RNA Sequencing in Situ 2014-03-20T18:26:41.395Z

The orchestration of these changes involves recruitment of fibroblasts, migration of immune cells, matrix remodelling and eventually development of vascular networks. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

Its process does not use stem cells but rather skin fibroblasts, specialized cells that produce collagen. Engineering the $325,000 In-Vitro Burger 2013-05-12T18:45:18Z

The audience waited in silence before he announced his surprisingly simple recipe: activating just four genes was enough to turn adult cells called fibroblasts back into pluripotent stem cells. Cell rewind wins medicine Nobel 2012-10-10T17:21:04.837Z

Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z

Quiescent fibroblasts differentially respond to damage, such as wounding, and become activated to support repair. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

The team, which described the new technique online September 15 in Molecular & Cellular Proteomics, verified its results by comparing the proteins they found with known secretory proteins made by mouse embryonic stem cells and fibroblasts. Cellular Calls: Listening in on Body's Protein "Chatter" May Lead to New Therapies 2012-10-03T11:15:08.683Z

But chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should. Chemotherapy 'undermines itself' 2012-08-06T02:33:24Z

Gene expression levels are shown relative to the fibroblasts. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

Yamanaka and his co-workers introduced these genes, in different combinations, into mature cells from connective tissue, fibroblasts, and examined the results under the microscope. The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z

Heterogeneity may be attributable to unique damage signals to which fibroblasts are exposed or possibly to their origin. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

Dermal fibroblasts suffered worse than keratinocytes, since they are usually not exposed to light. Can Compact Fluorescent Lightbulbs Damage Skin? 2012-07-25T15:15:05.457Z

Add four key genes to fibroblasts, and the cells go back in developmental time, regaining pluripotency: the ability to yield cell types descending from any of the three layers that make up the early embryo. Amniotic Fluid + Valproic Acid = New Source of Human Stem Cells 2012-07-03T16:15:04.193Z

Parental fibroblasts and aHeps were used as a negative and positive control, respectively. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

By introducing four genes together, they could reprogram their fibroblasts into immature stem cells! The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z

In it are fibroblasts from Tam and Gelogob, a blind and elderly female rhino in captivity at the Tabin Wildlife Reserve. Endangered species: Sex and the single rhinoceros 2012-05-30T17:50:32.700Z

In the same year, another group of scientists managed to transdifferentiate fibroblasts into the specific type of neuron that produces the neurotransmitter dopamine. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z

An analysis of biopsied tissue showed the procedure activated fibroblasts, a key component in connective tissue, led to new collagen deposits and triggered production of new blood vessels. Platelets Injected in ‘Vampire Lift’ Bolster Collagen Levels 2011-10-17T22:29:06Z

Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

An analysis showed the procedure activated fibroblasts, a key component in connective tissue, led to new collagen deposits and triggered production of new blood vessels. Platelets Injected During ‘Vampire Lift’ Bolster Collagen Levels 2011-10-17T21:02:01Z

Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person. Tell Us More Telomeres: Anecdotes from a Nobel Prize Winner 2011-10-17T12:15:00.240Z

They turned mouse skin cells — specifically, fibroblasts — into stem cells. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z

Cells called fibroblasts collaborate by secreting proteins the tumor needs to build its supportive scaffolding and expand into surrounding tissues. Cancer?s Secrets Come Into Sharper Focus 2011-08-15T17:02:05Z

Gene expression levels are shown relative to the fibroblasts. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

The sample is sent to the company’s laboratory, where the fibroblasts are multiplied in cell culture, a process that takes 11 to 22 weeks. Prescriptions: F.D.A. Approves Cell Therapy for Wrinkles 2011-06-22T19:08:01Z

We treated immortalized cell lines from the liver and kidney — the excretory organs that clear drugs from the body — and fibroblasts, cells involved in wound-healing, with BZP, its precursor chemicals and its reaction by-products. Poison in party pills is too much to swallow 2011-06-15T17:20:09.497Z

Furthermore, the fibroblasts that are the starting material for transdifferentiation do not divide as readily as iPSCs, limiting their use in applications that require lots of cells, such as drug screening, Wernig says. Human Skin Cells Turned into Nerve Cells 2011-05-26T21:15:00.263Z

The expression of three such proteins and the suppression of another called p19 was all that it took to persuade fibroblasts isolated from mouse tails to behave like liver cells. Reprogrammed Cells Repair Damaged Livers 2011-05-11T23:15:05.943Z

Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

Furthermore, knockdown of β-arrestin2 in fibroblasts from patients with idiopathic pulmonary fibrosis attenuated the invasive phenotype. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z

Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. [Research Articles] Stromal Endothelial Cells Directly Influence Cancer Progression 2011-01-19T22:55:12.407Z

In one study, a team at the Gladstone Institute of Cardiovascular Disease at the University of California, San Francisco made beating heart cells from more ordinary cells called fibroblasts. Plain cells turned into beating heart cells: study 2010-08-05T17:21:00Z

But harvesting fibroblasts is harder than drawing blood, requiring surgery and sutures. Stem Cells From Blood a 'Huge' Milestone 2010-07-02T14:42:00Z

Oshima and colleagues used embryonic stem cells from mice and a type of cell called a fibroblast cell for their experiment. Stem cells regrow crucial hearing cells in mice 2010-05-14T01:45:00Z

These data implicate β-arrestins as mediators of fibroblast invasion and the development of pulmonary fibrosis, and as a potential target for therapeutic intervention in patients with idiopathic pulmonary fibrosis. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z

Binder and colleagues dissolved human skin cells from pieces of skin, separating and purifying the various cell types such as fibroblasts and keratinocytes. Inkjet-like device 'prints' cells right over burns 2010-04-07T19:49:00Z

This directed the cells to exactly the right place, and allowed other types of cells, called fibroblasts, to align with the liver cells. 2010-01-26T00:00:00Z

This clot is soon permeated by newly formed blood vessels, and by leucocytes and fibroblasts, the latter being derived from proliferation of the cells of the marrow and periosteum. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition.

An extensive new formation of capillary loops and fibroblasts takes place towards the free surface, and goes on until the gap is filled by a fine velvet-like mass of granulation tissue. Manual of Surgery Volume First: General Surgery. Sixth Edition.

Fibrosis was prevented despite preserved recruitment of inflammatory cells and fibroblast chemotaxis. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z

However, isolated lung fibroblasts from bleomycin-treated β-arrestin–null mice failed to invade extracellular matrix and displayed altered expression of genes involved in matrix production and degradation. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z

This was important because fibroblasts are known to support the growth of liver cells. 2010-01-26T00:00:00Z

These fibroblasts ultimately develop into typical tendon cells, and the fibres which they form constitute the new tendon fibres. Manual of Surgery Volume First: General Surgery. Sixth Edition.

The spaces between these loops are filled by cells of various kinds, the most important being the fibroblasts, which are destined to form cicatricial fibrous tissue. Manual of Surgery Volume First: General Surgery. Sixth Edition.

单词	fibroblast
例句	fibroblast When combined with a dynamic magnetic field generated by an external device, the mechanical stimulation of the gel encourages dermal fibroblasts to become more active. NUS scientists develop innovative magnetic gel that heals diabetic wounds three times faster 2023-10-19T04:00:00Z As illustrated in Figure 1, loose connective tissue has some fibroblasts; macrophages are present as well. Fundamentals of Biology 2015-01-01T00:00:00Z Interestingly, humans and chimpanzees express USP14 at distinct levels in specific cell types, including cortical cells and fibroblasts. Biology for AP Courses 2022-06-09T00:00:00Z These modified fibroblasts may be able to replace embryonic stem cells, potentially solving the ethical problems. Miller & Levine Biology 2018-01-01T00:00:00Z Polysaccharides and proteins secreted by fibroblasts combine with extra-cellular fluids to produce a viscous ground substance that, with embedded fibrous proteins, forms the extra-cellular matrix. Anatomy and Physiology 2013-06-19T00:00:00Z Working with mice and with human skin samples, the scientists found that C. acnes triggers fibroblasts to transform into fat cells that secrete an antimicrobial substance—along with inflammation-causing proteins. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z Interspersed among the collagen fibers are long, thin fibroblasts. Fundamentals of Biology 2015-01-01T00:00:00Z As illustrated in Figure 24.12, loose connective tissue has some fibroblasts; macrophages are present as well. Biology for AP Courses 2022-06-09T00:00:00Z Skin cells are very good for this endeavour, particularly a type of connective tissue cell called a fibroblast. Extinction: Why scientists are freezing threatened species in 'biobanks' 2022-05-19T04:00:00Z As you might expect, a fibrocyte, a less active form of fibroblast, is the second most common cell type in connective tissue proper. Anatomy and Physiology 2013-06-19T00:00:00Z The researchers also discovered that retinoids, a powerful and commonly used class of pimple-fighting drug, work partially by blocking fibroblasts' transformation and release of irritating proteins. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z Adipose tissue, or fat tissue, is considered a connective tissue even though it does not have fibroblasts or a real matrix and only has a few fibers. Fundamentals of Biology 2015-01-01T00:00:00Z Though fragments of the blood clot may remain, fibroblasts and osteoblasts enter the area and begin to reform bone. Biology for AP Courses 2022-06-09T00:00:00Z Fusing a ferret fibroblast with an egg cell made an embryo, and a clone - Elizabeth Ann the black-footed ferret - was born in December of 2020. Extinction: Why scientists are freezing threatened species in 'biobanks' 2022-05-19T04:00:00Z Secreted by fibroblasts, ground substance is made of polysaccharides, specifically hyaluronic acid, and proteins. Anatomy and Physiology 2013-06-19T00:00:00Z Because retinoids can have undesirable side effects, she says, pursuing a more targeted way to stop the fibroblasts' transformation would be “fantastic” for clinical treatment. Acne Inflammation Discovery Could Lead to New Treatments 2022-06-16T04:00:00Z Neutrophils release substances that activate fibroblasts to begin to repair the area. Fundamentals of Biology 2015-01-01T00:00:00Z The principal cell of connective tissues is the fibroblast. Biology for AP Courses 2022-06-09T00:00:00Z Just like T cells engineered outside the body in traditional CAR-T therapy, they use the mRNA instructions to become primed to target and kill the fibroblast cells displaying FAP. Cutting-edge cancer and COVID-19 approaches could reduce organ scarring 2022-01-05T05:00:00Z As healing progresses, fibroblasts from the surrounding connective tissues replace the collagen and extracellular material lost by the injury. Anatomy and Physiology 2013-06-19T00:00:00Z The organoids are about 2 millimeters in diameter and include the main types of cells typically present in this stage of development: cardiomyocytes, epithelial cells, fibroblasts, and epicardium. Lab-grown minihearts beat like the real thing 2021-05-20T04:00:00Z The tear in the layers of skin prompts a type of skin cell — fibroblasts — to create collagen ropes and initiates a chain reaction of molecular events inside the skin cells. Imagine, Surgery Without a Scar 2021-04-22T04:00:00Z The fibers and other components of the connective tissue matrix are secreted by fibroblasts. Biology for AP Courses 2022-06-09T00:00:00Z In 2019, Epstein and his colleagues described success in applying the approach to fibrosis, with the goal of targeting connective tissue cells called fibroblasts that lay down excess scar tissue in the heart. Cutting-edge cancer and COVID-19 approaches could reduce organ scarring 2022-01-05T05:00:00Z Figure 4.21 Tissue Healing During wound repair, collagen fibers are laid down randomly by fibroblasts that move into repair the area. Anatomy and Physiology 2013-06-19T00:00:00Z They saw that cardiac fibroblasts, a type of cell responsible for maintaining tissue structure, migrated to the damaged areas to repair the dead cells, just as in babies that experience heart attacks. Lab-grown minihearts beat like the real thing 2021-05-20T04:00:00Z We also took skin fibroblasts, which are known to divide and grow, and overexpressed nerve growth factors and then inserted them into the hippocampus. Neuroscientist’s research helped unearth how human brains can make new cells 2021-02-05T05:00:00Z Skin cells known as fibroblasts are a common starting point because they are easy to collect, but they are hard to reprogram in some species. A menagerie of stem-cell models 2020-09-21T04:00:00Z They found that gene-expression changes were more evident in fibroblasts and endothelial cells than in epithelial cells. An antiviral response beyond immune cells 2020-06-30T04:00:00Z The repair phase includes blood clotting, followed by regeneration of tissue as fibroblasts deposit collagen. Anatomy and Physiology 2013-06-19T00:00:00Z “The fibroblasts in the dermis layer respond to that light and start acting as collagen factories again, growing new collagen,” says Pederson. Can LED light therapy turn back your skin’s clock? \| Provided by RenewAlliance 2020-06-30T04:00:00Z In addition, fibroblast cells in the tumour microenvironment secrete material that generates a physical barrier hindering the influx of T cells to the tumour site6. Pancreatic cancer hidden in plain sight 2020-04-21T04:00:00Z Human and mouse iPS cells are usually round and form tightly packed colonies, unlike the original fibroblasts, which tend to be flatter and generate sprawling cultures. A menagerie of stem-cell models 2020-09-21T04:00:00Z The year after the paper’s publication, human fibroblasts were directly converted into neurons10, although this required more transcription factors than were needed for the conversion of mouse cells. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z Interstitial fibroblasts within the kidney secrete EPO, thereby increasing erythrocyte production and restoring oxygen levels. Anatomy and Physiology 2013-06-19T00:00:00Z Asp et al. demonstrated that these fibroblast subgroups are located in distinct parts of the heart, providing a clue as to how they might function differently. Techniques converge to map the developing human heart at single-cell level 2020-01-26T05:00:00Z Given that fibroblasts regulate the extracellular matrix, the authors used microscopy to visualize physical features of fibres of the protein collagen, which is a component of the extracellular matrix. Ready-made cellular plugs heal skin wounds 2019-11-26T05:00:00Z Ward, whose children are 8, 7 and 4, said she paid nearly $500 for a procedure called fibroblast last November. Stretch mark removal procedure leaves mom with infected scars 2019-09-30T04:00:00Z The first example4 was the conversion of fibroblasts into muscle cells by inducing the cells to express the transcription factor MyoD. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z Before the basal stem cells of the stratum basale can recreate the epidermis, fibroblasts mobilize and divide rapidly to repair the damaged tissue by collagen deposition, forming granulation tissue. Anatomy and Physiology 2013-06-19T00:00:00Z But, she cautioned, there are several potential concerns for any therapy that attacks fibroblasts. This Treatment Can Cure Cancer. Can It Mend the Heart? 2019-09-11T04:00:00Z This barrier is formed in the lining layer, adjacent to a layer of cells called fibroblasts. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z These fibroblasts express the protein FAPα and are associated with bone and cartilage destruction. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z All of a sudden, fibroblasts — which are relatively easy to isolate from mouse embryos and are easy to grow in vitro — could be converted into a cell type of great therapeutic interest. A decade of questions about the fluidity of cell identity 2020-02-23T05:00:00Z Blood capillaries follow the fibroblasts and help increase blood circulation and oxygen supply to the area. Anatomy and Physiology 2013-06-19T00:00:00Z The group found one, fibroblast activation protein, or FAP, by looking through a large genetic database. This Treatment Can Cure Cancer. Can It Mend the Heart? 2019-09-11T04:00:00Z When arthritis was induced, the layer underwent active remodelling that loosened the physical interactions between barrier macrophages and lining-layer fibroblasts. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z To assess the functional role of the fibroblasts, the authors used their mouse model of arthritis5 to deplete fibroblasts during the initiation and maintenance phases of the disease. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z “The majority could be fibroblasts”—connective-tissue cells—“or other unhelpful cells.” The Birth-Tissue Profiteers 2019-05-07T04:00:00Z Cytokines are glycoproteins secreted by a wide variety of cells, including red bone marrow, leukocytes, macrophages, fibroblasts, and endothelial cells. Anatomy and Physiology 2013-06-19T00:00:00Z Bursac has recently woven in more complexity, adding populations of endothelial cells, which develop into blood vessels, and fibroblast cells, which he realized can help the patch form and become stronger. Lab-grown patch of heart muscle and other cells could fix ailing hearts 2019-04-24T04:00:00Z The challenge that lies ahead will be to develop ways of specifically targeting subsets of macrophages and fibroblasts with the ultimate goal of developing new treatments for people with arthritis. Macrophages form a protective cellular barrier in joints 2019-08-06T04:00:00Z The depletion of all FAPα-expressing fibroblasts led to a substantial reduction in the number of cells in the synovial membrane, suggesting a general reduction in inflammation. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z The authors report that the protein IL-6, which is synthesized in non-cancerous fibroblast cells adjacent to a pancreatic cancer, is a key driver of tumour invasion of the liver. Molecular envoys pave the way for pancreatic cancer to invade the liver 2019-03-05T05:00:00Z Dr. Akil and colleagues at the Pritzker Neuropsychiatric Disorders Research Consortium found that one growth factor that is depleted in depressed brains, called fibroblast growth factor 2, also plays a role in resilience. Opinion \| How to Be More Resilient 2018-12-15T05:00:00Z It also increases proliferation and migration of fibroblasts, the cells responsible for collagen production, and regulates signalling pathways related to inflammation, aiding wound healing. The edible skincare diet 2018-11-20T05:00:00Z When they created a wound on the back, they found that only one of two lineages of fibroblast — expressing homeobox protein engrailed-1 — was responsible for the formation of most scar tissue. Unlocking the secrets of scar-free skin healing 2018-11-20T05:00:00Z This protection from disease progression correlated with a loss of both fibroblast populations, but not with a loss of pericytes, a type of fibroblast found associated with blood vessels. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z Meanwhile, connective tissue cells called fibroblasts carry positional information that’s crucial for regrowing a limb. Salamander's Genome Guards Secrets of Limb Regrowth 2018-07-07T04:00:00Z Using methods that start with tissue cells called fibroblasts, researchers can engineer stem cells, which are cells capable of becoming any kind of body cell. Northern White Rhinos Are About to Die Out. Should We Save Them? 2018-03-13T04:00:00Z For years, researchers suspected that tattoos worked by permanently staining fibroblasts, the cells that synthesize collagen, under the surface of our skin. The Cells That Eat, Regurgitate and Eat Your Tattoos Again 2018-03-06T05:00:00Z But the cells usually used to make these clones—connective tissue cells called fibroblasts—are short-lived, Cibelli notes, and can only divide 20 or 30 times. First cow embryonic stem cells could lead to healthier, more productive livestock 2018-02-05T05:00:00Z To test the individual contributions of the two fibroblast populations directly, the authors isolated cells that either expressed or lacked Thy-1, and injected them into the inflamed joints of arthritic mice. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z They say the affect of the body clock on skin cells called fibroblasts is responsible for the difference. News Daily: May's Patel replacement and best injury times 2017-11-09T05:00:00Z Detailed lab work showed skin cells called fibroblasts were changing their abilities in a 24-hour pattern. Daytime wounds 'heal more quickly' 2017-11-08T05:00:00Z These cellular contractors tell fibroblasts to move into an injury to begin the healing process. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z Despite recent success in directly reprogramming fibroblasts into various cell types, the precise changes that occur as fibroblasts progressively convert to the target cell fates remain unclear. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte 2017-10-24T04:00:00Z Mice that received Thy-1-expressing fibroblasts developed more-severe inflammatory arthritis, but not greater bone or cartilage destruction than was the case for animals that did not receive a cellular transplant. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z Total RNA was prepared from untreated and IFN-treated mouse embryonic fibroblasts in a similar way. Dynamic landscape and regulation of RNA editing in mammals : Nature : Nature Research 2017-10-10T04:00:00Z In animal skins both the synthesis of the initial amino-acid chains and their subsequent winding into fibres are done by special cells called fibroblasts. Leather grown using biotechnology is about to hit the catwalk 2017-08-24T04:00:00Z The fibroblasts filled in scratches more quickly during the day than at night. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z Detailed functional analysis of the top candidate splicing factor, Ptbp1, revealed that it is a critical barrier for the acquisition of cardiomyocyte-specific splicing patterns in fibroblasts. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte 2017-10-24T04:00:00Z These exciting findings raise the possibility that clinical strategies might be developed for the selective depletion, targeted replacement or functional conversion of fibroblast subpopulations. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z The researchers mapped the PERVs interwoven into the genome of pig connective tissue cells, called fibroblasts. How turning off viruses in piglets could make their organs safer for people 2017-08-10T04:00:00Z The fibroblasts produce a molecule called collagen 12, which changes the structure of the support matrix that surrounds nerve fibres. Scientists hope fish clues aid spinal cord injury treatment - BBC News 2017-07-25T04:00:00Z Given the fibroblasts’ time-keeping abilities, O’Neill and colleagues searched for proteins within the cells that ebb and flow with daily rhythms. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z This yielded two subgroups of fibroblasts — one that sits next to and interacts with the cancer cells, and another that is located farther away and produces tumour-boosting inflammatory molecules. Cancer: Tumours live in diverse areas : Nature : Nature Research 2017-03-07T05:00:00Z Cells called fibroblasts contribute to the development of rheumatoid arthritis2, a condition characterized by damage to the joints that is marked by inflammation and the destruction of bone and cartilage. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z The scientists have run a series of unpublished experiments to determine how much X-ray radiation is necessary to suppress fibroblast growth. Biologists struggle with push to eliminate radioactive caesium in labs 2016-05-09T04:00:00Z Meanwhile, skin cells called dermal fibroblasts that normally produce collagen become less efficient at doing so. Cosmetics: Molecular beauty : Nature : Nature Publishing Group 2015-10-06T04:00:00Z About twice as many fibroblasts migrated into the daytime wounds as nighttime ones. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z Finally, fibroblasts rearrange collagen fibers to further strengthen the tissue that has closed over the wound. A better way to analyze how wounds are healing 2015-05-04T04:00:00Z Working with mice, the team focused on two kinds of fibroblasts, which are cells responsible for maintaining the structural integrity of organs, tissues and more. The Strange Way a Diabetes Drug May Help Skin Scars 2015-04-16T04:00:00Z But B lymphocytes will not divide unless they are activated — here, by the presence of connective-tissue cells called fibroblasts. Biologists struggle with push to eliminate radioactive caesium in labs 2016-05-09T04:00:00Z These were then surrounded by other cell types, such as skin fibroblasts, which interact with these hepatocyte islands to help maintain liver-specific metabolic function and gene-activity profiles that would otherwise be lost. Artificial organs: Honey, I shrunk the lungs : Nature : Nature Publishing Group 2015-03-24T04:00:00Z The researchers say that fibroblasts’ time-varying response may be an evolutionary adaptation. Daytime wounds heal more quickly than those suffered at night 2017-11-08T05:00:00Z Then, special cells called fibroblasts secrete a collagen scaffolding to allow new tissue to grow, filling in any skin gap left by the cut and promoting the growth of new blood vessels. A better way to analyze how wounds are healing 2015-05-04T04:00:00Z When he treated the cells with diphtheria toxin, which destroys the fibroblasts, the animals scarred less. The Strange Way a Diabetes Drug May Help Skin Scars 2015-04-16T04:00:00Z Notably, there appears to be a large expansion of the B compartment upon differentiation of human ES cells to MS cells or in IMR90 fibroblasts. Chromatin architecture reorganization during stem cell differentiation : Nature : Nature Publishing Group 2015-02-17T05:00:00Z But the factors act differently when shoved into a differentiated cell such as a fibroblast. Stem cells: The black box of reprogramming 2014-12-09T05:00:00Z The anti-malarial drug chloroquine causes some people to itch — especially people of African ancestry — and studying itch cells made from their fibroblasts could help to explain why, she adds. Pain and itch neurons grown in a dish 2014-11-24T05:00:00Z Two others held suspensions of fibroblasts, the gristly cells that form the body’s connective tissue. How 3-D Printing Is Changing Medicine 2014-11-17T05:00:00Z To assess the biological significance of the genetics, reprogramming human skin fibroblast cells into neurons and gene-editing technologies will be hugely useful. Mental health: Depression needs large human-genetics studies 2014-11-11T05:00:00Z Typically, these cells are fibroblasts, the cells that make up the body’s connective tissue. For $100,000, You Can Clone Your Dog 2014-10-22T04:00:00Z These ensure that only genes relevant for a fibroblast are expressed. Stem cells: The black box of reprogramming 2014-12-09T05:00:00Z The machine works by placing two types of human cell - keratinocytes and fibroblasts - layer-by-layer into a hydrogel to create the desired patterns. Skin printer and bee probe win award 2014-09-17T04:00:00Z The process began by taking connective tissue cells called fibroblasts from mouse embryos and "tweaking" their DNA to increase production of a protein called FOXN1. Scientists hail creation of working organ made from laboratory cells 2014-08-24T04:00:00Z The second purification step was to isolate fibroblasts from the cell population by using CD10 beads for magnetic purification. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway 2014-04-04T18:28:18.449Z He arranged for fibroblasts to be collected from the dog, which is currently working in Afghanistan and whose identity is classified. For $100,000, You Can Clone Your Dog 2014-10-22T04:00:00Z Parental fibroblasts and aHeps were used as a negative and positive control, respectively. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z The technique was tested in fibroblasts to reveal the differences between individual cells during wound repair. [Report] Highly Multiplexed Subcellular RNA Sequencing in Situ 2014-03-20T18:26:41.395Z The orchestration of these changes involves recruitment of fibroblasts, migration of immune cells, matrix remodelling and eventually development of vascular networks. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Its process does not use stem cells but rather skin fibroblasts, specialized cells that produce collagen. Engineering the $325,000 In-Vitro Burger 2013-05-12T18:45:18Z The audience waited in silence before he announced his surprisingly simple recipe: activating just four genes was enough to turn adult cells called fibroblasts back into pluripotent stem cells. Cell rewind wins medicine Nobel 2012-10-10T17:21:04.837Z Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z Quiescent fibroblasts differentially respond to damage, such as wounding, and become activated to support repair. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z The team, which described the new technique online September 15 in Molecular & Cellular Proteomics, verified its results by comparing the proteins they found with known secretory proteins made by mouse embryonic stem cells and fibroblasts. Cellular Calls: Listening in on Body's Protein "Chatter" May Lead to New Therapies 2012-10-03T11:15:08.683Z But chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should. Chemotherapy 'undermines itself' 2012-08-06T02:33:24Z Gene expression levels are shown relative to the fibroblasts. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z Yamanaka and his co-workers introduced these genes, in different combinations, into mature cells from connective tissue, fibroblasts, and examined the results under the microscope. The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z Heterogeneity may be attributable to unique damage signals to which fibroblasts are exposed or possibly to their origin. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Dermal fibroblasts suffered worse than keratinocytes, since they are usually not exposed to light. Can Compact Fluorescent Lightbulbs Damage Skin? 2012-07-25T15:15:05.457Z Add four key genes to fibroblasts, and the cells go back in developmental time, regaining pluripotency: the ability to yield cell types descending from any of the three layers that make up the early embryo. Amniotic Fluid + Valproic Acid = New Source of Human Stem Cells 2012-07-03T16:15:04.193Z Parental fibroblasts and aHeps were used as a negative and positive control, respectively. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z By introducing four genes together, they could reprogram their fibroblasts into immature stem cells! The 2012 Nobel Prize in Physiology or Medicine 2012-10-08T11:45:05.853Z In it are fibroblasts from Tam and Gelogob, a blind and elderly female rhino in captivity at the Tabin Wildlife Reserve. Endangered species: Sex and the single rhinoceros 2012-05-30T17:50:32.700Z In the same year, another group of scientists managed to transdifferentiate fibroblasts into the specific type of neuron that produces the neurotransmitter dopamine. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z An analysis of biopsied tissue showed the procedure activated fibroblasts, a key component in connective tissue, led to new collagen deposits and triggered production of new blood vessels. Platelets Injected in ‘Vampire Lift’ Bolster Collagen Levels 2011-10-17T22:29:06Z Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z An analysis showed the procedure activated fibroblasts, a key component in connective tissue, led to new collagen deposits and triggered production of new blood vessels. Platelets Injected During ‘Vampire Lift’ Bolster Collagen Levels 2011-10-17T21:02:01Z Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person. Tell Us More Telomeres: Anecdotes from a Nobel Prize Winner 2011-10-17T12:15:00.240Z They turned mouse skin cells — specifically, fibroblasts — into stem cells. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z Cells called fibroblasts collaborate by secreting proteins the tumor needs to build its supportive scaffolding and expand into surrounding tissues. Cancer?s Secrets Come Into Sharper Focus 2011-08-15T17:02:05Z Gene expression levels are shown relative to the fibroblasts. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z The sample is sent to the company’s laboratory, where the fibroblasts are multiplied in cell culture, a process that takes 11 to 22 weeks. Prescriptions: F.D.A. Approves Cell Therapy for Wrinkles 2011-06-22T19:08:01Z We treated immortalized cell lines from the liver and kidney — the excretory organs that clear drugs from the body — and fibroblasts, cells involved in wound-healing, with BZP, its precursor chemicals and its reaction by-products. Poison in party pills is too much to swallow 2011-06-15T17:20:09.497Z Furthermore, the fibroblasts that are the starting material for transdifferentiation do not divide as readily as iPSCs, limiting their use in applications that require lots of cells, such as drug screening, Wernig says. Human Skin Cells Turned into Nerve Cells 2011-05-26T21:15:00.263Z The expression of three such proteins and the suppression of another called p19 was all that it took to persuade fibroblasts isolated from mouse tails to behave like liver cells. Reprogrammed Cells Repair Damaged Livers 2011-05-11T23:15:05.943Z Parental fibroblasts were used as a negative control. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z Furthermore, knockdown of β-arrestin2 in fibroblasts from patients with idiopathic pulmonary fibrosis attenuated the invasive phenotype. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. [Research Articles] Stromal Endothelial Cells Directly Influence Cancer Progression 2011-01-19T22:55:12.407Z In one study, a team at the Gladstone Institute of Cardiovascular Disease at the University of California, San Francisco made beating heart cells from more ordinary cells called fibroblasts. Plain cells turned into beating heart cells: study 2010-08-05T17:21:00Z But harvesting fibroblasts is harder than drawing blood, requiring surgery and sutures. Stem Cells From Blood a 'Huge' Milestone 2010-07-02T14:42:00Z Oshima and colleagues used embryonic stem cells from mice and a type of cell called a fibroblast cell for their experiment. Stem cells regrow crucial hearing cells in mice 2010-05-14T01:45:00Z These data implicate β-arrestins as mediators of fibroblast invasion and the development of pulmonary fibrosis, and as a potential target for therapeutic intervention in patients with idiopathic pulmonary fibrosis. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z Binder and colleagues dissolved human skin cells from pieces of skin, separating and purifying the various cell types such as fibroblasts and keratinocytes. Inkjet-like device 'prints' cells right over burns 2010-04-07T19:49:00Z This directed the cells to exactly the right place, and allowed other types of cells, called fibroblasts, to align with the liver cells. 2010-01-26T00:00:00Z This clot is soon permeated by newly formed blood vessels, and by leucocytes and fibroblasts, the latter being derived from proliferation of the cells of the marrow and periosteum. Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition. An extensive new formation of capillary loops and fibroblasts takes place towards the free surface, and goes on until the gap is filled by a fine velvet-like mass of granulation tissue. Manual of Surgery Volume First: General Surgery. Sixth Edition. Fibrosis was prevented despite preserved recruitment of inflammatory cells and fibroblast chemotaxis. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z However, isolated lung fibroblasts from bleomycin-treated β-arrestin–null mice failed to invade extracellular matrix and displayed altered expression of genes involved in matrix production and degradation. [Research Articles] {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix 2011-03-16T19:55:11.913Z This was important because fibroblasts are known to support the growth of liver cells. 2010-01-26T00:00:00Z These fibroblasts ultimately develop into typical tendon cells, and the fibres which they form constitute the new tendon fibres. Manual of Surgery Volume First: General Surgery. Sixth Edition. The spaces between these loops are filled by cells of various kinds, the most important being the fibroblasts, which are destined to form cicatricial fibrous tissue. Manual of Surgery Volume First: General Surgery. Sixth Edition.
随便看	libertarianism libertine liberty Liberty Bell liberty cap Liberty Island Liberty Party Liberty ship libidinal libidinal energy libidinous libido Libocedrus Libra librarian librarianship library library card library catalog library catalogue library fine library paste library program library science librate