| 单词 | epitope |
| 例句 | "Previous efforts to target this receptor have been unsuccessful. But now that we've identified this epitope, there could be a therapeutic path forward to target Fas in tumors," Tushir-Singh said. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z Note that recognition occurs at a specific epitope rather than on the entire antigen; for this reason, epitopes are known as “antigenic determinants.” Biology for AP Courses 2022-06-09T00:00:00Z The word "epitope" means the substance that the immune system recognizes and protects against. Why BA.5 became the dominant COVID variant 2022-08-10T04:00:00Z Others, such as epitope tagging, use antibodies to track marked proteins, revealing their location and abundance in cells and providing hints about their function. ‘Gold mine of unexplored biology’: Short protein sequences could dramatically expand human genome 2022-07-21T04:00:00Z B cells respond most strongly when each arm attaches to a different epitope. Vaccines that can protect against many coronaviruses could prevent another pandemic 2021-04-15T04:00:00Z While Fas plays an essential role in regulating immune cells, Tushir-Singh and his colleagues knew they might be able to target cancer cells selectively if they found the right epitope. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z The variable domains from the heavy and light chains interact to form the binding site through which an antibody can bind a specific epitope on an antigen. Biology for AP Courses 2022-06-09T00:00:00Z Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. Structural basis of potent Zika–dengue virus antibody cross-neutralization : Nature : Nature Research 2016-06-22T04:00:00Z The new therapies all incorporate multiple antigens to anticipate epitope spreading, for example. Immunology: A tolerant approach 2014-03-26T18:20:25.689Z A 7 Å resolution cryoelectron microscopy map of Fab fragments of HM14c10 in a complex with DENV1 shows targeting of a discontinuous epitope that spans the adjacent surface of envelope protein dimers. [Research Articles] The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody 2012-06-20T18:55:24.963Z Having identified this specific epitope, he and other researchers can now design a new class of antibodies to selectively bind to and activate Fas to potentially destroy tumor cells specifically. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z Antibodies secreted after binding to one epitope on an antigen may exhibit cross reactivity for the same or similar epitopes on different antigens. Biology for AP Courses 2022-06-09T00:00:00Z The antibodies recognize a snippet of the protein called an epitope, and recruit the immune system to attack the bacterium. Antibodies Linked to Long-Term Lyme Disease Symptoms 2011-08-05T19:45:00.463Z Miller documented this phenomenon, known as epitope spreading, in animal models 20 years ago. Immunology: A tolerant approach 2014-03-26T18:20:25.689Z Thus, MF59 quantitatively and qualitatively enhances functional antibody responses to HA-based vaccines by improving both epitope breadth and binding affinity, demonstrating the added value of such adjuvants for influenza vaccines. [Research Articles] MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines 2011-06-01T18:55:21.157Z In fact, the study showed tumors with a mutated version of the epitope of Fas receptors will not respond to CAR T at all. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z "We should know a patient's Fas status -- particularly the mutations around the discovered epitope -- before even considering giving them CAR T," Tushir-Singh said. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z |
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