| 单词 | epigenetic |
| 例句 | As the choreographer Moriah Evans sees it, we all have bodies and we all have stuff — our everyday possessions, our emotional baggage, our epigenetic history. The Dance Laboratory of an Existential Fidgeter 2022-12-16T05:00:00Z What is supposed to happen at reproduction – and mostly does – is that all the epigenetic marks acquired during life are erased and every birth is a fresh start. Identically Different: Why You Can Change Your Genes by Tim Spector – review 2012-08-08T09:30:03Z But the case of Dolly the sheep and other animals cloned since then show that where adult cells have been reprogrammed to wipe out the epigenetic marks, the process is inefficient. Identically Different: Why You Can Change Your Genes by Tim Spector – review 2012-08-08T09:30:03Z Cloned cats are not true to the original in coat colour because that trait is an unpredictable epigenetic phenomenon. Identically Different: Why You Can Change Your Genes by Tim Spector – review 2012-08-08T09:30:03Z But even in normal reproduction, it seems that some epigenetic marks can persist for a few generations. Identically Different: Why You Can Change Your Genes by Tim Spector – review 2012-08-08T09:30:03Z "In populations where exposure to trauma is widespread and sustained, epigenetic changes can become hardwired to enable survival." Trauma seems to be passed down genetically — but experts still aren't sure what that means 2023-11-19T05:00:00Z The researchers discovered that vitamin B12 insufficiency during reprogramming or tissue repair resulted in significant epigenetic changes, leading to errors in the function of multiple genes. Vitamin B12: A key player in cellular reprogramming and tissue regeneration 2023-11-16T05:00:00Z In their new study, Mirny and his colleagues wanted to answer the question of how those epigenetic marks are maintained from generation to generation. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z While previous studies have shown that mutations in the genes that encode epigenetic factors can affect an individual's cancer susceptibility, little is known about how the levels of these factors impact cancer progression. AI model can help predict survival outcomes for patients with cancer 2023-11-16T05:00:00Z This research project is a part of the larger program supported by NSF Rules of Life program that aims to decipher epigenetic inheritance mechanism of eCO2 responses across a broad range of plants. Research provides crucial insights into moss growth under elevated CO2 levels that may benefit climate change models 2023-11-14T05:00:00Z He also experienced epigenetic changes, modifications in how genes are expressed that can be heritable, a feature that helps humans and other creatures preserve useful adaptations without waiting for evolution to do its brutal work. The Bodily Indignities of the Space Life 2023-11-12T05:00:00Z Next, his team wants to explore how mitochondrial respiration influences the epigenetic programming of T cells, for example through post-translational modifications of histones, and the interplay of T-cell metabolism with the local tissue microenvironment. Immunology: Dysfunction of mitochondria drives the exhaustion of T cells 2023-11-02T04:00:00Z When a cell copies its DNA to divide it between two daughter cells, each copy gets about half of the epigenetic marks. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z To see if there was a relationship between epigenetic patterns and clinical outcomes, the researchers analyzed the expression patterns of 720 epigenetic factors to classify tumors from 24 different cancer types into distinct clusters. AI model can help predict survival outcomes for patients with cancer 2023-11-16T05:00:00Z The path a cell takes from healthy to metastatic cancer is mostly driven by epigenetic changes, according to a new computational study. Epigenetic changes are paramount in cancer progression 2023-11-06T05:00:00Z An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. A known environmental hazard can change the epigenetics of cells 2023-11-02T04:00:00Z The proof-of-concept study with a set of 22 twins found an epigenetic signature in buccal or cheek cells appearing only for the twins who were obese compared to their thinner siblings. Epigenetic signature for obesity found in study of twins 2023-11-01T04:00:00Z The new model suggests possible parallels between epigenetic memories stored in a folded polymer and memories stored in a neural network, he adds. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z The team then used epigenetic factor gene expression levels to train and test an AI model to predict patient outcomes. AI model can help predict survival outcomes for patients with cancer 2023-11-16T05:00:00Z There is a vast epigenetic programme controlling in such way the general working of the cell and, when altered, it may put it at the starting line of malignant transformation. Epigenetic changes are paramount in cancer progression 2023-11-06T05:00:00Z This advantage can become a drawback, though, as this epigenetic regulation can be more easily altered by toxins than the more stable genetic sequence of the DNA. A known environmental hazard can change the epigenetics of cells 2023-11-02T04:00:00Z The fact that the epigenetic signature was found in cheek cells rather than fat cells also suggests that the obesity signature is likely found throughout the human system. Epigenetic signature for obesity found in study of twins 2023-11-01T04:00:00Z While this model appeared to offer a good explanation for how epigenetic memory can be maintained, the researchers found that eventually, reader-writer enzyme activity would lead to the entire genome being covered in epigenetic modifications. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z "Similar epigenetic factor-based models could be generated for pediatric cancers to see what factors influence the decision-making process compared to the models built on adult cancers." AI model can help predict survival outcomes for patients with cancer 2023-11-16T05:00:00Z To do this, researchers used a range of tests including blood biomarkers, skin autofluorescence and epigenetic clocks. Most accurate test to date developed to measure biological aging 2023-10-13T04:00:00Z Dr. Pontel summarizes it as "we have discovered that formaldehyde has the capacity to modify the epigenetic landscape of our cells, which might contribute to the well-documented carcinogenic properties of formaldehyde." A known environmental hazard can change the epigenetics of cells 2023-11-02T04:00:00Z Joseph Ecker, a molecular biologist at the Salk Institute for Biological Studies in La Jolla, California, and his colleagues investigated the brain through an epigenetic lens using tissue samples from the same three donors. This Is The Largest Map of The Human Brain Ever Made 2023-10-13T04:00:00Z To get the model to more accurately account for the preservation of epigenetic marks, the researchers added another element: limiting the amount of reader-writer enzyme available. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z Researchers at Linköping University have used data with epigenetic information from more than 75,000 human samples to train a large number of AI neural network models. A step towards AI-based precision medicine 2023-10-11T04:00:00Z To address this, the team developed a new, more accurate epigenetic clock -- the Glasgow-Karolinska Clock -- that works on healthy and unhealthy tissue. Most accurate test to date developed to measure biological aging 2023-10-13T04:00:00Z The epigenetic changes caused by the toxic agent could directly contribute to the origin of the mentioned diseases, beyond its known mutagenic properties. A known environmental hazard can change the epigenetics of cells 2023-11-02T04:00:00Z This novel insight challenges conventional thinking about the role of epigenetic factors and their impact on cellular function. Epigenetic regulator MOF drives mitochondrial metabolism 2023-10-09T04:00:00Z "The mechanistic link between these mutations and the epigenetic changes that eventually happen is not well understood," Owen says. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z There are already existing models of the effects of smoking on the body, building on the fact that specific epigenetic changes reflect the effect of smoking on the functioning of the lungs. A step towards AI-based precision medicine 2023-10-11T04:00:00Z This study is the first real-world test of epigenetic clocks in a normal ageing setting, and against clinical parameters. Most accurate test to date developed to measure biological aging 2023-10-13T04:00:00Z Komarova and colleagues found that the EB3 inhibitor they developed reversed these epigenetic changes, restoring gene expression to a normal, healthy state. New strategy for eye condition could replace injections with eyedrops 2023-10-03T04:00:00Z The findings suggest that an interplay of genetic and epigenetic changes feed on each other to drive the pathological manifestations of the disease. Decoding the complexity of Alzheimer's disease 2023-09-28T04:00:00Z These modifications generate "epigenetic memory," which helps a cell to maintain its cell type. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z Other models can, based on epigenetic markers, estimate the chronological age of an individual, or group individuals according to whether they have a disease or are healthy. A step towards AI-based precision medicine 2023-10-11T04:00:00Z In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. Timing plant evolution with a fast-ticking epigenetic clock 2023-09-29T04:00:00Z One locus at a time, they studied the associated variants with a special consideration of epigenetic signatures and 3D genome interaction annotations indicating their likelihood of functioning in microglia. Researchers connect Alzheimer's-associated genetic variants with brain cell function 2023-09-22T04:00:00Z This alters the profile of metabolites in the cells, boosting the levels of molecules that inhibit an epigenetic enzyme known as KDM5 and so changing the deposition of a key epigenetic "mark" on their chromosomes. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Previous work by Mirny's lab has shown that the 3D structure of folded chromosomes is partly determined by these epigenetic modifications, or marks. How cell identity is preserved when cells divide 2023-11-16T05:00:00Z Although the existing models rely on selected epigenetic markers known to be associated with the condition they aim to classify. A step towards AI-based precision medicine 2023-10-11T04:00:00Z It is linked with better general perceived health as well, and a new study released last month reports that green space reduces “epigenetic aging,” an evaluation of biological age based on gene expression. Can Virtual Reality Mimic Nature’s Power to Make Us Healthier? 2023-07-14T04:00:00Z Scientists have found that early-onset colorectal cancers have different molecular, epigenetic and genetic characteristics than those diagnosed later in life. Colon cancer is rising among younger adults. Here’s what to know. 2023-03-27T04:00:00Z He and his colleagues will also explore whether cancer cells adapt to hijack the metabolism and epigenetic regulation of T cells to push them into a less persistent, terminal effector state. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Sinclair’s team set out to test his “information theory of aging,” which posits that our bodies get old because of the cumulative loss of epigenetic marks. Two research teams reverse signs of aging in mice 2023-01-12T05:00:00Z "By testing for both genetic and epigenetic changes, we could, potentially, much more accurately predict which treatments will work best for a particular person's cancer," Prof Graham said. 'Dark matter' find could change cancer treatment 2022-10-26T04:00:00Z In some diseases, alteration to epigenetic modifications turns off genes that are normally expressed. Biology for AP Courses 2022-06-09T00:00:00Z If epigenetic changes take place above the level of the genome, what would be an example of a change at the level of the genome? Miller & Levine Biology 2018-01-01T00:00:00Z How might an epigenetic gold deposit be related to a porphyry deposit? Physical Geology 2015-01-01T00:00:00Z To see whether the epigenetic degradation was reversible, the researchers injected some of these elderly seeming mice with AAVs carrying OSK genes, which Sinclair’s group recently reported could reverse loss of vision in aging rodents. Two research teams reverse signs of aging in mice 2023-01-12T05:00:00Z The researchers say their findings cannot prove that epigenetic changes directly lead to alterations in the way cancers behave, and more work needs to be done to show this occurs. 'Dark matter' find could change cancer treatment 2022-10-26T04:00:00Z Changes in epigenetic modifications alter the accessibility and transcription of DNA. Biology for AP Courses 2022-06-09T00:00:00Z These chemical marks on chromatin are epigenetic, or above the level of the genome. Miller & Levine Biology 2018-01-01T00:00:00Z They also speculated that childhood physical abuse could alter gut bacteria, lead to chronic inflammation, decrease brain volume, diminish cellular immunity and cause epigenetic changes. The seven health conditions linked to childhood physical abuse 2022-07-11T04:00:00Z Analyses of the mice’s muscles, kidneys, and retinas suggest the cocktail reversed some of the epigenetic changes induced by the DNA breaks. Two research teams reverse signs of aging in mice 2023-01-12T05:00:00Z And she discusses what we know so far about how epigenetic effects can be transmitted through eggs and sperm. Students Deserve to Learn about the Climate Emergency 2022-07-01T04:00:00Z This form of regulation, called epigenetic regulation, occurs even before transcription is initiated. Biology for AP Courses 2022-06-09T00:00:00Z The environment can often influence how and when epigenetic marks are attached to chromatin. Miller & Levine Biology 2018-01-01T00:00:00Z Given the epigenetic and other changes occurring with sustained responses to trauma, the feedback loop might become recalibrated. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z They also partially regained patterns of DNA methylation—a type of epigenetic mark—typical of younger animals. Two research teams reverse signs of aging in mice 2023-01-12T05:00:00Z They compared these so-called epigenetic changes in dogs of various ages to those in humans. A better way to gauge ‘dog years’ 2022-04-22T04:00:00Z This type of gene regulation is called epigenetic regulation. Biology for AP Courses 2022-06-09T00:00:00Z Telomere shortening and epigenetic changes are also thought to play a role. Mutations across species reveal clues to ageing 2022-04-13T04:00:00Z But there is some evidence that the epigenetic response may serve as an adaptation that might help the children of traumatized parents cope with similar adversities. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z The mice ended up with an epigenetic signature more like that of older animals, and their health deteriorated. Two research teams reverse signs of aging in mice 2023-01-12T05:00:00Z In general, these epigenetic changes dialed up the operation of genes involved in muscle growth while quieting gene activity elsewhere, making the genetic process of building muscle “more refined,” Dr. Murach said. How ‘Muscle Memory’ May Help Us Get in Shape 2022-01-05T05:00:00Z These changes can alter epigenetic accessibility, transcription, mRNA stability, or translation—all resulting in changes in expression of various genes. Biology for AP Courses 2022-06-09T00:00:00Z Changes in such observable characteristics that do not involve changes to the underlying DNA sequence are referred to as epigenetic changes. Stress in utero: COVID chaos and babies’ future health 2021-12-05T05:00:00Z Given the obvious difficulties in studying generations of people, scientists often resort to animal studies to explore epigenetic transmission. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z She found that oxLDL induced epigenetic changes that enabled the cells to make more cytokines after they had been exposed to an unrelated immune-triggering compound. Immune Cells That Remember Inflammation Could Offer Treatment Targets for Atherosclerosis 2021-12-01T05:00:00Z The study also looked at the epigenetic age of women, a measurement taken by looking at DNA extracted from white blood cells. Do pregnancy and childbirth accelerate aging in women? Maybe. 2019-10-18T04:00:00Z Changes in epigenetic regulation, transcription, RNA stability, protein translation, and post-translational control can be detected in cancer. Biology for AP Courses 2022-06-09T00:00:00Z The researchers also found an epigenetic mark that these children had in common. The long echo of WW2 trauma 2019-06-07T04:00:00Z Intriguingly, the male offspring of the shocked mice demonstrated a similar fear of cherry blossoms—as well as epigenetic changes in their brain and sperm—without being exposed to the shock. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z The cells had all the hallmarks of trained immunity, including heightened cytokine responses, epigenetic changes and alterations to metabolism-related genes. Immune Cells That Remember Inflammation Could Offer Treatment Targets for Atherosclerosis 2021-12-01T05:00:00Z By studying the population of cells in the DNA, researchers can determine a person’s epigenetic age. Do pregnancy and childbirth accelerate aging in women? Maybe. 2019-10-18T04:00:00Z Increasingly, scientists understand how epigenetic changes are altered in cancer. Biology for AP Courses 2022-06-09T00:00:00Z But O'Neill cautions that epigenetic marks are most likely to indicate a predisposition rather than an inevitable outcome - and they can be reversed, she says. The long echo of WW2 trauma 2019-06-07T04:00:00Z It is tempting to interpret epigenetic inheritance as a story of how trauma results in permanent damage. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z However, the study was small—just 16 people—and the team is still testing whether the intervention altered epigenetic changes or other signs of trained immunity. Immune Cells That Remember Inflammation Could Offer Treatment Targets for Atherosclerosis 2021-12-01T05:00:00Z The results were similar to what the telomeres indicated: The more pregnancies a woman went through, the “older” her epigenetic age. Do pregnancy and childbirth accelerate aging in women? Maybe. 2019-10-18T04:00:00Z Genes involved in the development of many other illnesses, ranging from allergies to inflammation to autism, are thought to be regulated by epigenetic mechanisms. Biology for AP Courses 2022-06-09T00:00:00Z “Every day, try to be hungry and out of breath” is his neatly epigenetic epigram. Can We Live Longer but Stay Younger? 2019-05-13T04:00:00Z And Dias and Ressler reconditioned their mice to lose their fear of cherry blossoms; the offspring conceived after this “treatment” did not have the cherry blossom epigenetic alteration, nor did they fear the scent. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z But intergenerational epigenetic effects can pass down the male line as well. The ramifications of a new type of gene 2018-02-22T05:00:00Z These epigenetic regulators may act to facilitate the expression and/or repression of genes that are necessary for the initiation of gametocyte development in the subsequent cell cycle. Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites 2017-09-24T04:00:00Z What type of epigenetic modifications are present in new seedlings and after cold exposure? Biology for AP Courses 2022-06-09T00:00:00Z In conclusion, this study embodies an unparalleled resource of high-resolution genetic, epigenetic and transcriptional data for the childhood brain tumour MB. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z This epigenetic modification suggests a potential explanation for how trauma might reset cortisol levels. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z These analyses have uncovered many recurrent mutations in epigenetic regulator proteins, which modulate gene expression by altering the 3D structure of chromosomes. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z Distortions in epigenetic age seem to parallel other diseases more closely. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z As with the epigenetic and transcriptional stages of processing, this post-transcriptional step can also be regulated to control gene expression in the cell. Biology for AP Courses 2022-06-09T00:00:00Z Every phenomenon in development that is proved the direct result of epigenetic factors can be discounted from the complexity of the germinal mass. Encyclopaedia Britannica, 11th Edition, Volume 13, Slice 3 "Helmont, Jean" to "Hernosand" 2012-04-14T02:00:23.707Z Could some of these epigenetic changes in trauma survivors also be found in the children of trauma survivors? How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z Most other AML-associated mutations in genes that encode epigenetic regulators cause protein inactivation, but mutations in IDH genes are an exception. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z Medical researchers might be able to use the epigenetic clock to better diagnose and classify illnesses even without really understanding how the biology works. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z Which of the following is true of epigenetic changes? Biology for AP Courses 2022-06-09T00:00:00Z The labours of Roux, as well as the valuable researches of Driesch, induced me to carry out a series of experiments with the object of getting a surer basis for my epigenetic conception of development. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z The response was accompanied by epigenetic changes in its brain and sperm. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z Tellingly, the combination therapies dramatically reduced the percentage of circulating cells that were derived from the donor mice, suggesting that two-pronged therapies that target both epigenetic dysregulation and kinase signalling can induce potent antileukaemic responses. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z The more active this mechanism, he proposes, the faster the epigenetic clock ticks. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z And there may be medical implications in cases in which epigenetic estimates do not match a person's birth certificate. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z Now he explains candidly that he has been driven to the view that epigenetic development does not exist. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z The finding confirmed that healing is also reflected in epigenetic change. How Parents’ Trauma Leaves Biological Traces in Children 2022-06-25T04:00:00Z Their work provides a compelling rationale for clinical trials of combined epigenetic- and kinase-targeted therapies. Cancer therapy: The leukaemia epigenome targeted : Nature : Nature Research 2017-03-28T04:00:00Z Horvath acknowledges that it will take more work to find out whether epigenetic age predicts the onset of disease and decrepitude better than a calendar does. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z “If he's right that there is something like an inherently epigenetic clock at work in ageing, that is very interesting. It must be important.” Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z In my theory two assumptions of totally contrasting nature are made: I assume a germplasm of high and specific organisation, and I assume that this is transformed into the adult product by epigenetic agencies. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z The researchers were looking for an epigenetic pattern that correlated with sexual orientation. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z Criminal investigators, for example, might find an epigenetic clock handy for establishing the age of a victim or an assailant by analysing any biological residues left behind. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z As cells age, the pattern of epigenetic alterations shifts, and some of the changes seem to mark time. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z Horvath says that unpublished work from two other large studies also finds epigenetic age acceleration to be a substantial risk factor for mortality, even after controlling for chronological age and other well-known risk factors. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z Last year, Ideker and his collaborators reported that the epigenetic ages of breast, kidney, lung and skin cancers were 40% older, on average, than the patients from which they were removed. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z “But the epigenetic clock gives us a new start and a new hope of something that will affect ageing,” he says. Biomarkers and ageing: The clock-watcher 2014-04-09T17:20:26.613Z |
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