| 单词 | Enbrel |
| 例句 | Amgen sees revenue from the Horizon medicines helping to offset increased competition that has eroded sales of its blockbuster rheumatoid arthritis drug Enbrel. US FTC sues to block Amgen's $27.8 bln deal for Horizon Therapeutics 2023-05-16T04:00:00Z Amgen hopes they can act as a bulwark against competition for its blockbuster arthritis drug Enbrel. FTC to block Amgen's deal to acquire Horizon Therapeutics - source 2023-05-16T04:00:00Z Following AbbVie’s footsteps, Amgen has piled up patents for its anti-inflammatory drug Enbrel, delaying a copycat version by an expected 13 years after it won regulatory approval. How a Drug Company Made $114 Billion by Gaming the U.S. Patent System 2023-01-28T05:00:00Z She also began giving herself injections of Enbrel, a medicine used to treat moderate or severe RA. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Before she became eligible for Medicare, Deborah Rosenwinkel, who lives in Wheaton, Ill., and has rheumatoid arthritis, used a manufacturer’s discount card for Enbrel, a biologic she injected at home once a week. When a Diagnosis Demands a Long-Term Money Strategy 2022-01-14T05:00:00Z The biotechnology company said a U.S. district court ruled in its favor in a patent dispute involving the arthritis drug Enbrel. Amgen and Sysco rise while Viacom and Bank of America fall 2019-08-12T04:00:00Z Pfizer said science does not support using Enbrel to prevent Alzheimer’s, particularly because the molecule is too large to cross the blood-brain barrier. Alzheimer’s research is getting a reboot at small companies focused on the immune system 2019-07-03T04:00:00Z Pope said he can’t afford the thousands of dollars Enbrel would cost him under his Medicare plan. Future is in doubt for cheaper versions of biologic drugs - Washington Times 2019-06-27T04:00:00Z She was advised to immediately stop taking methotrexate and Enbrel and begin high doses of folinic acid, which counters the effects of methotrexate. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Earlier this month, The Washington Post published a report claiming that researchers from Pfizer found that its rheumatoid arthritis therapy drug Enbrel reduced the risk of Alzheimer’s disease by 64 percent. An Alzheimer's vaccine may finally be within scientists' reach 2019-06-12T04:00:00Z A team of researchers inside Pfizer made a startling find in 2015: The company’s blockbuster rheumatoid arthritis therapy Enbrel, a powerful anti-inflammatory drug, appeared to reduce the risk of Alzheimer’s disease by 64 percent. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Sales of rheumatoid arthritis drug Enbrel fell 11 percent to $1.3 billion, about in line with Wall Street estimates. Amgen quarterly profit beats Wall Street view on new product sales 2018-07-26T04:00:00Z Prescription drugs for rheumatoid arthritis include powerful biologic medications sold under brand names Humira and Enbrel, which act on the immune system to slow the disease. Many in Middle Age Have Arthritis—They Just Don’t Know It 2018-04-23T04:00:00Z My doctor put me on Enbrel with a brief chat about risks, but no mention of mortality, which is why I left his office happy and confident. This Warning May Cause Severe Anxiety 2018-03-28T04:00:00Z But the insurer that oversees her drug plan, Humana, is pocketing hundreds of dollars every time she fills her prescription from Amgen, which makes Enbrel. Lower Drug Prices: New Proposals Carry Lots of Promises 2018-02-09T05:00:00Z The company told The Post that it decided during its three years of internal reviews that Enbrel did not show promise for Alzheimer’s prevention because the drug does not directly reach brain tissue. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Near-copies of Enbrel, an injected immune disorder drug it sells overseas, cut sales 18 percent to $588 million in the quarter, for example. Pfizer beats 1Q profit forecasts, but sales slip 2017-05-02T04:00:00Z The best-selling products Humira and Enbrel, which treat the skin disease psoriasis and other conditions, carry annual list prices of about $50,000. Severe Eczema Drug Is Approved by F.D.A.; Price Tag Is $37,000 a Year 2017-03-28T04:00:00Z Another man was filmed selling Enbrel, a specialist arthritis drug, for £250. NHS prescription drugs being sold illegally by patients - BBC News 2017-01-15T05:00:00Z Ms. Lopez, 70, takes Enbrel for rheumatoid arthritis, and she’s watched in frustration as her out-of-pocket costs have risen along with the drug’s list price. Lower Drug Prices: New Proposals Carry Lots of Promises 2018-02-09T05:00:00Z Profits are dwindling as generic competition emerges, diminishing financial incentives for further research into Enbrel and other drugs in its class. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z “Enbrel is in a highly competitive marketplace where several large products compete,” Neese said. The bizarre reason two competing drug prices rose in tandem 2016-11-07T05:00:00Z Still, its price is a bit lower than many other commonly used biologic drugs, such as Humira and Enbrel, that treat other skin diseases. Severe Eczema Drug Is Approved by F.D.A.; Price Tag Is $37,000 a Year 2017-03-28T04:00:00Z Amgen said it wasn’t likely to raise net prices going forward on its rival drug, Enbrel. Big Pharma Sales Need a Booster Shot 2016-11-01T04:00:00Z Amgen said the higher rebates would help ensure that drug plans continue to reimburse for patients’ use of Enbrel. Backlash Against Drug Prices Hits Manufacturers and Middlemen 2016-10-28T04:00:00Z By industry standards, Enbrel, an injectable biologic drug, is relatively old, with FDA approval for rheumatoid arthritis in 1998. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z In a recent earnings call, Amgen reported that it sold less of Enbrel in the past quarter and expected “little benefit” from net price increases next year. The bizarre reason two competing drug prices rose in tandem 2016-11-07T05:00:00Z The biotech drugmaker said sales of its biggest drug, Enbrel, were flat as new competition looms. McKesson and Amazon fall; Alphabet and Baker Hughes climb 2016-10-28T04:00:00Z And even better--my wife takes Enbrel for her arthritis. The EpiPen, a Case Study in Health System Dysfunction 2016-08-23T04:00:00Z Amgen Inc. shares dropped 10% after the company late Thursday flagged diminished pricing power next year for its blockbuster rheumatoid-arthritis treatment Enbrel, after several years of sales gains fueled by repeated price hikes. Backlash Against Drug Prices Hits Manufacturers and Middlemen 2016-10-28T04:00:00Z Another drug company, Amgen, which holds rights to market Enbrel in the United States and Canada, says it knew of the Pfizer data and similarly decided the findings held little promise. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Remicade and Enbrel, two of the world’s top-selling drugs because of their steep prices, treat rheumatoid arthritis, psoriasis, colitis and other immune system disorders. Insider Q&A: Why so little relief on pricey biologic drugs 2016-09-18T04:00:00Z Meanwhile, Amgen's battle to prolong patents it maintains shield Enbrel for another 13 years is far from resolved. Novartis bid to sell new biosimilar crimped by U.S. court battles 2016-08-31T04:00:00Z The next day it voted 20 to 0 in favor of a broad approval of the Enbrel biosimilar, which was developed by Sandoz, the generic division of Novartis, and tested only in patients with psoriasis. Makers of Humira and Enbrel Using New Drug Patents to Delay Generic Versions 2016-07-15T04:00:00Z Enbrel sales made up one-quarter of Amgen’s top line over that period. A Threat to Biotechs, but a Slow-Motion One 2016-07-12T04:00:00Z But none of the experts interviewed for this story said such “off-label’’ use of Enbrel would be appropriate for Alzheimer’s, because of the very limited nature of the data thus far. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z In one trial, ixekizumab was tested against a placebo; in the other two, it was pitted against a placebo and Enbrel for the first 12 weeks, and then just the placebo from then on. New Psoriasis Drug Works Longer Term, Too 2016-06-08T04:00:00Z The price hikes for Enbrel and other drugs “seem to have increased in magnitude and frequency,” he said. Drugmakers Raise Prices Despite Criticisms 2016-01-11T05:00:00Z Sales of Enbrel, for rheumatoid arthritis and other immune disorders, jumped 30 percent to $1.46 billion in the quarter. Drugmaker Amgen posts big increases in 3Q profit, sales 2015-10-28T04:00:00Z Analysts likewise forecast a similarly mild decline for Enbrel. A Threat to Biotechs, but a Slow-Motion One 2016-07-12T04:00:00Z In 2016, researchers from Dartmouth and Harvard universities published a study of insurance claims data — similar to Pfizer’s internal findings — that showed a potential benefit of Enbrel. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Older biologics include brands like Enbrel and Remicade, which target an immune system chemical called TNF. New Psoriasis Drug Works Longer Term, Too 2016-06-08T04:00:00Z An Amgen spokeswoman said the price of Enbrel reflects its clinical benefits, while helping fund “continued scientific innovation.” Drugmakers Raise Prices Despite Criticisms 2016-01-11T05:00:00Z The company runs a plant in West Greenwich that makes Enbrel. Rhode Island to receive $760K in settlement with Amgen 2015-08-19T04:00:00Z Enbrel was promoted for mild cases of plaque psoriasis, despite being only approved for severe cases; it was also advertised to be far more effective than scientifically shown, according to the complaint. Pharmaceutical Giant Amgen Settles for $71 Million 2015-08-18T04:00:00Z Enbrel “shows promise as a potential treatment’’ for Alzheimer’s, the study found. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Together, Enbrel and the new medicines offset declines in sales of older Amgen medicines for anemia in chemotherapy and kidney dialysis patients and for preventing infections in chemotherapy patients. Amgen hikes 2015 forecast after 2Q increase in profit, sales 2015-07-30T04:00:00Z Mariah Leach of Louisville, Colo., said she would have preferred to pick up Enbrel, the drug for her rheumatoid arthritis, at her grocery store pharmacy, along with all her other prescriptions. Specialty Pharmacies Proliferate, Along With Questions 2015-07-15T04:00:00Z He added a deal to promote psoriatic arthritis drug Enbrel after he was diagnosed with the disease in 2010 and used the drug for his treatment. Phil Mickelson Tops Tiger Woods As Golf's Highest-Paid Player 2015-06-15T04:00:00Z Enbrel is used to treat multiple conditions, notably chronic and severe plaque psoriasis. Pharmaceutical Giant Amgen Settles for $71 Million 2015-08-18T04:00:00Z The Enbrel molecule is too large to pass through the “blood-brain barrier’’ and directly target TNF-a in brain tissue, the company said. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z Sales of biologic rheumatoid arthritis drug Enbrel, long a company mainstay, rose 8 percent mainly due to price hikes, to a total of $1.35 billion. Amgen hikes 2015 forecast after 2Q increase in profit, sales 2015-07-30T04:00:00Z “Too bad my insurance forces me to get my Enbrel though this particular pharmacy, otherwise I’d have ditched this place after strike two,” she wrote in a blog post in October 2013. Specialty Pharmacies Proliferate, Along With Questions 2015-07-15T04:00:00Z She treats Chris Cloud, the Utah teen with juvenile arthritis who takes Enbrel. Specialty drugs save lives, come with daunting price tags 2015-03-11T04:00:00Z The pharmaceutical company was accused of promoting its two brands, Aranesp and Enbrel, for uses not approved by the FDA. Pharmaceutical Giant Amgen Settles for $71 Million 2015-08-18T04:00:00Z “I don’t believe Enbrel would need to cross the blood brain barrier to modulate the inflammatory/immune response within the brain,’’ Walker said. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z These are drugs such as Humira or Enbrel for rheumatoid arthritis and psoriasis, and Tysabri for multiple sclerosis and Crohn’s disease. Why Are Biologic Drugs So Costly? 2015-02-06T05:00:00Z Enbrel is a drug used for the treatment of plaque psoriasis, rheumatoid arthritis and psoriatic arthritis. What 2015 Will Bring For Pfizer? 2015-01-12T05:00:00Z Initially, 222 patients spent a year on weekly injections of Enbrel, along with the oral drug methotrexate. Lower Doses of Rheumatoid Arthritis Drugs May Work for Some 2014-11-05T05:00:00Z Immunex produced Enbrel, a breakthrough drug used in the treatment of rheumatoid arthritis and other autoimmune diseases. Guest: We can do more to support Washington biotechnology 2014-11-02T04:00:00Z The blockbuster rheumatoid arthritis drug Enbrel saw sales fall three percent to $1.12 billion, shy of the $1.17 billion analysts were expecting. Amgen profit tops Wall Street expectations; raises 2014 outlook 2014-10-27T04:00:00Z But it's already the basis for dozens of drugs approved for use in the U.S., including the cancer drug Avastin and the rheumatoid arthritis drug Enbrel. U.S. seeks to speed up production of Ebola drug 2014-09-03T04:00:00Z About 54 percent of secukinumab patients reported a 90 percent improvement in their symptoms, compared with 20 percent for Enbrel, the study found. New Psoriasis Drug Shows Promise in Trials 2014-07-09T04:00:00Z About six months later, some remained in remission; those who'd been on lower doses of Enbrel and methotrexate fared the best -- with 44 percent still in remission. Lower Doses of Rheumatoid Arthritis Drugs May Work for Some 2014-11-05T05:00:00Z From 67 to 81 percent of patients who took Novartis’s secukinumab achieved that goal, far better than the 5 percent who received a placebo and the 44 percent for those who used Enbrel. Drugs Show Promise in Treating Eczema and Psoriasis in Trials 2014-07-09T04:00:00Z Inventory stocking issues hurt Enbrel in the quarter, the company said. Amgen profit tops Wall Street expectations; raises 2014 outlook 2014-10-27T04:00:00Z Last quarter’s results were disappointing as well, due to the continued impact of generic competition as well as the expiration of certain co-promotion agreements for drugs such as Enbrel. Why Pfizer May Not Give Up On AstraZeneca 2014-05-30T04:00:00Z The only side effect appears to be an increased risk of infection, which was higher than placebo in both studies but similar to that of Enbrel. New Psoriasis Drug Shows Promise in Trials 2014-07-09T04:00:00Z The data follow results last year showing the drug was superior to Amgen's Enbrel in a head-to-head study. Novartis psoriasis drug effective when self-administered - studies 2014-03-22T09:06:27Z Enbrel, a blockbuster product sold by Amgen Inc and Pfizer, works by blocking a protein called tumor necrosis factor, that is linked to inflammation. Pfizer's drug shows mixed results in psoriasis trials 2013-10-09T13:20:32Z The increased revenue was helped by a 9 percent increase in sales of the rheumatoid arthritis treatment Enbrel and a surge in demand for newer, fast-growing products Xgeva and Prolia. UPDATE 1-Amgen profit tops Wall Street view; rebounds from 1st qtr 2013-07-30T20:46:24Z My fiancé was given a diagnosis of R.A. last year but after six months of taking prednisone, methotrexate and Enbrel his condition only worsened. Ask an Expert: Answers About Rheumatoid Arthritis, Part 2 2013-07-24T12:00:01Z Company sales rose only 5 percent in emerging markets due in part to reduced government purchases of Prevnar 13 and of the company's Enbrel treatment for rheumatoid arthritis. UPDATE 4-Pfizer results fall short; company trims profit forecast 2013-04-30T18:47:52Z All have billions of dollars in annual sales and, with the possible exception of Enbrel, are expected to lose patent protection in the next several years. Battle in States on Generic Copies of Biotech Drugs 2013-01-29T02:24:34Z They include off-label marketing of other drugs like Enbrel for psoriasis and Neulasta, which increases the levels of white blood cells. Amgen Workers Helped U.S. in Aranesp Marketing Inquiry 2012-12-20T01:37:39Z It also said it and Pfizer will continue to work together on the arthritis drug Enbrel. Takeda to stop selling 13 Pfizer drugs in Japan 2012-06-18T03:29:32Z Sales of the arthritis treatment Enbrel and the painkiller Celebrex each rose 7 percent, with Enbrel at $865 million and Celebrex, $622 million. Pfizer and Eli Lilly, Squeezed by Generics, Top Forecasts 2012-01-31T23:25:26Z In November, Amgen got a new patent covering the active ingredient in Enbrel, preventing generic competition for more than a decade. Next Amgen CEO sees expansion to new markets, higher sales from newer products, share buybacks 2012-01-09T21:39:17Z The main patent on Enbrel was to expire in October of next year. Amgen?s New Enbrel Patent May Undercut Health Care Plan 2011-11-23T14:37:27Z “This is a relatively cheap drug compared to the biologics like Enbrel.” Arthritis Drug’s $1.4 Billion Promise for 4SC Hinges on Study 2011-05-25T22:22:32Z The arthritis treatment Enbrel generated $870 million in sales for the quarter. Pfizer Profit Beats Analysts’ Estimates on Lower Costs 2011-05-03T14:13:05Z The most commonly used biotech medicines for psoriasis, such as Amgen Inc's Enbrel, target a protein known as tumor necrosis factor. Abbott psoriasis drug succeeds in pivotal trial 2010-10-11T16:12:00Z Weekly shots of Enbrel lower his immune system, and Mickelson said the difference was noticeable almost immediately. Arthritis diagnosis forced Mickelson off his feet before U.S. Open 2010-08-10T23:08:00Z Amgen executives said earlier this year that they did not anticipate biosimilar competition to Enbrel in the next five years anyway, in part because of other patents covering the use or formulations of Enbrel. Amgen?s New Enbrel Patent May Undercut Health Care Plan 2011-11-23T14:37:27Z Weekly shots of Enbrel, which lowers his immune system, have brought the disease under control. Mickelson?s arthritis so bad he couldn?t walk 2010-08-10T20:44:00Z “Enbrel is widely considered to be one of the most important biosimilar molecules,” a Merck executive said in a statement at that time. Amgen?s New Enbrel Patent May Undercut Health Care Plan 2011-11-23T14:37:27Z Briakinumab demonstrated superior skin clearance rates to Enbrel in earlier Phase III studies that also had data presented at the meeting in Sweden. Abbott psoriasis drug succeeds in pivotal trial 2010-10-11T16:12:00Z And Enbrel might face competition from generic versions of other arthritis drugs, including Abbott Laboratories’ Humira, and from new oral drugs that might reach the market in the next few years. Amgen?s New Enbrel Patent May Undercut Health Care Plan 2011-11-23T14:37:27Z |
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