| 单词 | amaurosis |
| 例句 | Trial participants have Leber congenital amaurosis type 10, caused by a mutated gene that the trial aimed to fix. News at a glance: A telescope’s namesake questioned, flood-risk maps, and an extinct woodpecker 2021-10-06T04:00:00Z Last July, the pharmaceutical companies Editas Medicine in Cambridge, Massachusetts, and Allergan in Dublin launched a trial to treat the genetic disorder Leber congenital amaurosis 10, which can cause blindness, by editing eye cells. Quest to use CRISPR against disease gains ground 2020-01-05T05:00:00Z Caspian was born with a rare, inherited eye disorder called Leber congenital amaurosis, which results in the progressive deterioration of the retina, the tissue at the back of the eye that detects light and color. High Hopes for a Gene Therapy Come With Fears Over Cost 2018-09-24T04:00:00Z More studies involving human beings are expected in other countries for the treatment of beta-thalassaemia, a blood disorder, and Leber’s congenital amaurosis, a form of blindness. The safety of CRISPR-Cas9 gene editing is being debated 2018-07-19T04:00:00Z Effect of gene therapy on visual function in Leber’s congenital amaurosis. Restoring vision 2018-05-15T04:00:00Z The disorder caused by the mutation is called Leber congenital amaurosis, a more precise diagnosis than Willis got as a teen in Tennessee. Medical breakthrough: Seattle man is first adult to get new gene therapy for vision 2018-04-01T04:00:00Z Children with the gene mutation often are diagnosed at an early age with disorders such as Leber congenital amaurosis or retinitis pigmentosa. FDA approves first gene therapy for an inherited disease 2017-12-18T05:00:00Z Though rare, Leber congenital amaurosis is one of a group of disorders called inherited retinal diseases, which are caused by roughly 220 different genetic mutations. High Hopes for a Gene Therapy Come With Fears Over Cost 2018-09-24T04:00:00Z Children with the dysfunctional gene often are diagnosed at an early age with disorders such as Leber congenital amaurosis or retinitis pigmentosa. FDA advisers urge approval for first gene therapy for inherited disease 2017-10-12T04:00:00Z Plasticity of the human visual system after retinal gene therapy in patients with Leber’s congenital amaurosis. Restoring vision 2018-05-15T04:00:00Z A disease called Leber’s congenital amaurosis left her legally blind at age 4. Gene therapies offer dramatic promise but shocking costs 2015-11-11T05:00:00Z The first project likely to be tried out in patients, she says, is a treatment for Leber’s congenital amaurosis type 10, a genetic form of blindness. Bill Gates And 13 Other Investors Pour $120 Million Into Revolutionary Gene-Editing Startup 2015-08-10T04:00:00Z Leber's congenital amaurosis affects the functioning of the retina, the light-sensitive tissue at the back of the eye. Gene therapy's 'temporary benefits' for retina disease - BBC News 2015-05-03T04:00:00Z Weakness of sight, without and opacity of the cornea, or of the interior of the eye; the first degree of amaurosis. Webster's Unabridged Dictionary 2012-03-24T02:00:23.513Z What had before been a merely stationary dimness of vision became a slowly progressive decay of sight, or, to express it in medical language, amblyopia had passed into amaurosis. William Hickling Prescott 2012-03-11T03:00:12.297Z During the attack, her eyelids were generally half shut, and frequently resembled those of a person labouring under amaurosis, the pupil dilated and insensible. Curiosities of Medical Experience 2012-03-09T03:00:20.410Z Leber congenital amaurosis is a collection of disorders that lead to loss of cells in the retina in the first few decades of patients’ lives, the study said. Blindness-Busting Gene Therapy Works in Second Eye, Study Finds 2012-02-08T19:24:55Z Short-sightedness, amaurosis, distortion of the spine, excessive constitutional debility, indigestion, and derangement of the uterine functions, may be said to be almost universal: all the evidence points to this conclusion.' Cannibals all! or, Slaves without masters 2011-03-06T03:00:21.020Z Affected with amaurosis; having the characteristics of amaurosis. Webster's Unabridged Dictionary 2012-03-24T02:00:23.513Z But researchers at Children's Hospital of Philadelphia have used gene therapy to help improve worsening eyesight in 12 patients with a rare blinding disease called Leber congenital amaurosis, or LCA. Gene therapy appears to help patient with anemia 2010-09-15T18:33:00Z Am′blyopy, dullness or obscurity of eyesight without any apparent defect in the organs; the first stage of amaurosis. The New Gresham Encyclopedia. Vol. 1 Part 1 A to Amide Cataract may be simple, or complicated with amaurosis, adhesions, etc. Special Report on Diseases of Cattle It was likewise used in intermittent fever, in bilious affections, amaurosis, hernia humoralis, dysentery, chronic rheumatism, &c. North American Medical and Surgical Journal, Vol. 2, No. 3, July, 1826 If there are still some who cannot see that I am right, then let them, without delay, be operated upon for amaurosis. Public School Education Now there is another test of the collegiate amaurosis, or cataract, or whatever it may be, which has lasted 700 years, and has thus attained its incurable character. Buchanan's Journal of Man, August 1887 Volume 1, Number 7 The diagnosis was the same—amblyopia, atrophy of the nerve, and incipient amaurosis; which in plain language meant dimness of vision increasing to blindness. The Wreck of the Titan or, Futility In amaurosis the pupil is dilated to its full extent; the eye looks clear, but does not respond to light. Special Report on Diseases of the Horse Failure of Special Senses.—Dimness of vision, amaurosis, spots before the eyes, with other forms of ocular weakness, are common results of this vice. Plain Facts for Old and Young In the least unfavourable case, aggravated near-sightedness follows; in the worst case, which is frequent enough, incurable blindness from amaurosis. The Condition of the Working-Class in England in 1844 with a Preface written in 1892 Among them—and I quote these from the full notes furnished by Dr. Behrend—were complete paraplegia, left hemiplegia, complete hysterical amaurosis, but from this she had recovered in 1868. Fat and Blood An Essay on the Treatment of Certain Forms of Neurasthenia and Hysteria Upon medical examination it appeared that his blindness was caused by amaurosis, which is generally accepted as an affection of the optic nerve. A Compilation of the Messages and Papers of the Presidents Volume 8, part 3: Grover Cleveland, First Term Lafontaine, Schlegel, and Hartman all assure us that the section of the affected masses before this time has been known to be followed by amaurosis, convulsions, apoplexy, epilepsy, and even death. Anomalies and Curiosities of Medicine In this case there was partial amaurosis in both sides, although nothing of disease could be discovered in the left eye. The Dog For the winders, however, it is certain that their work seriously affects the eye, and produces, besides the frequent inflammations of the cornea, many cases of amaurosis and cataract. The Condition of the Working-Class in England in 1844 with a Preface written in 1892 In the examination of cases of the untoward effects of quinin upon the eye, Knapp of New York found the power of sight diminished in various degrees, and rarely amaurosis and immobility of the pupils. Anomalies and Curiosities of Medicine He has also amaurosis. perfect blindness, which had not appeared the day before. The Dog The patient recovered in four months, but suffered from amaurosis which had commenced at the time of the stab. Anomalies and Curiosities of Medicine In 'amaurosis', the eye is beautifully clear, and, for a little while, this clearness imposes upon the casual observer; but there is a peculiar pellucid appearance about the eye—a preternatural and unchanging brightness. The Dog |
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