| 单词 | digoxin |
| 例句 | It shares this category with aloe vera leaves, electromagnetic radiation, the heart drug digoxin and engine exhaust fumes, among many other things. Aspartame might be classified as a possible carcinogen by WHO — but there’s no cause for panic 2023-07-05T04:00:00Z There, he murdered three elderly women with overdoses of the heart medication digoxin. From "Capturing the Killer Nurse" to "The Good Nurse," here's the true story of Charles Cullen 2022-11-15T05:00:00Z He was put on digitalis and digoxin and, to rid him of his excess water weight, the diuretic Lasix. John Wayne’s political last days: Ronald Reagan, Jimmy Carter and a beautiful Oscars farewell 2014-11-28T05:00:00Z But prosecutors had additional evidence: Investigators had found traces of the heart medication digoxin in the body of one alleged victim and an overdose of the sedative chloral hydrate in another. Unlucky numbers: Fighting murder convictions that rest on shoddy stats 2023-01-18T05:00:00Z He ingratiates himself into her life, including befriending her two children, before she begins to realize he is spiking IV bags with drugs like insulin and digoxin, causing patients to die suddenly. What's fact and what's fiction in Netflix's tale of serial killer Charles Cullen 2022-10-26T04:00:00Z Next he injects digoxin into the fetus, which stops the heart. Pioneering abortion doctor fears Roe’s fall: ‘We’ll see a lot of ... women dying’ 2022-03-10T05:00:00Z When the same dataset was analysed on the basis of sex, it showed digoxin decreased mortality in men – but increased mortality in women. Not accounting for sex differences in Covid research could be deadly 2020-09-25T04:00:00Z When they fed mice the amino acid arginine, however, digoxin levels stayed high. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z The infant who had allegedly died of digoxin poisoning had been declining for days after heart surgery. Unlucky numbers: Fighting murder convictions that rest on shoddy stats 2023-01-18T05:00:00Z Microbes can also sabotage the classic cardiac drug digoxin, which is used to treat arrhythmias and heart failure. How Gut Microbes Shape Our Response to Drugs 2020-01-19T05:00:00Z Other examples of gut bacteria affecting drugs include the microbial inactivation of digoxin, which is used for heart conditions4, and the bacterial modification of the chemotherapeutic agent irinotecan, which causes toxic side effects5. Microbes make metabolic mischief by targeting drugs 2019-06-16T04:00:00Z A stark example was the heart drug digoxin, which was widely marketed in the late 1990s on the basis of a trial that showed it to be effective and safe. Not accounting for sex differences in Covid research could be deadly 2020-09-25T04:00:00Z The researchers are not sure why that’s so, but it means that giving arginine along with digoxin could protect the drug. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z The most common problems associated with digoxin are nausea and loss of appetite, but it’s other effects are more intriguing. It was all yellow: did digitalis affect the way Van Gogh saw the world? 2017-08-10T04:00:00Z “I’m not doing digoxin,” she said, “and we’re just going to document, and there’s never been a problem.” New video shows Planned Parenthood skirting partial-birth abortion law 2017-07-27T04:00:00Z In 2014, The New York Times cited the soaring price of digoxin, the company’s congestive heart failure drug. Defiant, Generic Drug Maker Continues to Raise Prices 2017-04-14T04:00:00Z Similarly, the effectiveness of digoxin depends on whether the gut of an individual contains specific strains of Eggerthella lenta, the plasmids of which encode an enzyme that rapidly degrades digoxin and renders it ineffective14. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z As with the heart medication digoxin, that could mean supplementing a drug with another compound that influences its mechanism of interaction. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z One of the compounds, digoxin, is listed by the World Health Organisation as an essential medicine because of its huge benefit in the treatment of abnormal heart rhythms such as atrial fibrillation. It was all yellow: did digitalis affect the way Van Gogh saw the world? 2017-08-10T04:00:00Z The number of prescriptions written each year for generic versions prednisone, tetracycline and digoxin likely run into the millions. Investigating the mystery of soaring generic medication prices 2015-10-11T04:00:00Z Many patients on digoxin are older, as is the case with fluphenazine. Defiant, Generic Drug Maker Continues to Raise Prices 2017-04-14T04:00:00Z In addition, digoxin may not mix well with other drugs, leading to dangerous overdoses. Heart Drug Digoxin May Not Be Best for Some Heart Patients 2015-05-05T04:00:00Z “Eye-popping” increases, such as that for digoxin, are generally isolated events, he says. Much ado about something 2015-04-30T04:00:00Z However, the undoubted benefit of digoxin and its long history of use means it is a vital part of modern medicine. It was all yellow: did digitalis affect the way Van Gogh saw the world? 2017-08-10T04:00:00Z Although digoxin was also linked to a higher risk for death among patients diagnosed with both atrial fibrillation and heart failure, that association appeared somewhat weaker, the researchers said. Common Drug for Irregular Heartbeat Tied to Worse Outcomes 2015-03-04T05:00:00Z These naturally-occurring drugs, such as digoxin, are used therapeutically to manage congestive heart failure but are potentially lethal at several-fold higher doses. Deadly 'Crocodile Bile' Brew Poison Identity Inconclusive, Says Mozambique Official 2015-01-29T05:00:00Z "If digoxin is used, careful monitoring of patients for digoxin blood levels seems mandatory," Hohnloser said. Heart Drug Digoxin May Not Be Best for Some Heart Patients 2015-05-05T04:00:00Z According to Express Scripts, a drug wholesaler, the price of digoxin, a treatment for congestive heart failure, went up by 1,127% last year. Much ado about something 2015-04-30T04:00:00Z To achieve these effects on the heart, digoxin and related compounds interact with the enzyme Na+/K+ ATPase. It was all yellow: did digitalis affect the way Van Gogh saw the world? 2017-08-10T04:00:00Z Qureshi stressed that it's unclear exactly what drives the observed risk posed by digoxin. Common Drug for Irregular Heartbeat Tied to Worse Outcomes 2015-03-04T05:00:00Z That included Arthur P. Bedrosian, the chief executive of Lannett, which has raised the price of generic digoxin by nearly 1,000 percent, a sudden price rise examined recently by The New York Times. Lawmakers Look for Ways to Provide Relief for Rising Cost of Generic Drugs 2014-11-24T05:00:00Z For the study, Hohnloser and colleagues analyzed 19 previously published studies that looked at the connection between digoxin use and death from atrial fibrillation and heart failure. Heart Drug Digoxin May Not Be Best for Some Heart Patients 2015-05-05T04:00:00Z "Given the other options available for heart-rate control, digoxin should be used with caution in the management of atrial fibrillation, especially in the absence of symptomatic systolic heart failure," Steimle believes. Treating Irregular Heartbeat With Digoxin May Come With Risks 2014-11-21T05:00:00Z This was the case with digoxin, an oral medication used to treat atrial fibrillation and heart failure, he noted in his editorial. U.S. Prices Soaring for Some Generic Drugs, Experts Say 2014-11-12T05:00:00Z Currently, the American Heart Association and the American College of Cardiology include digoxin as a first-line therapy for the condition, he said. Common Drug for Irregular Heartbeat Tied to Worse Outcomes 2015-03-04T05:00:00Z These include thyroid replacement hormone, the antibiotic doxycycline, the heart pill digoxin and the asthma pill albuterol. Lawmakers Look for Ways to Provide Relief for Rising Cost of Generic Drugs 2014-11-24T05:00:00Z However, Turakhia thinks the risk may be the result of digoxin causing other dangerous abnormal heart rhythms. Heart Medication Digoxin Linked to Higher Risk of Death for Some 2014-08-11T04:00:00Z Given the high rate of adverse events caused by the drug, he recommends that digoxin should only be used “selectively and with care in AF patients.” Study Offers Little Support for an Old Drug 2014-08-11T04:00:00Z The drug, digoxin, is used every day by millions of mostly older patients, including many with atrial fibrillation, or A-fib. New Concerns About an Old Heart Drug 2014-08-11T04:00:00Z "We found a very strong signal that a significant portion of digoxin users faced an increased risk for death, versus those who took other medications," Qureshi added. Common Drug for Irregular Heartbeat Tied to Worse Outcomes 2015-03-04T05:00:00Z Alternatives to digoxin, and so market competition, are scarce. As Vital Generic Drug Prices Soar, So Do Pharmaceuticals' Profits 2014-07-09T04:00:00Z Given that there are other treatments for atrial fibrillation, Turakhia wonders why digoxin should be the treatment of choice for these patients. Heart Medication Digoxin Linked to Higher Risk of Death for Some 2014-08-11T04:00:00Z Nearly 29,000 patients who received digoxin were matched with an equal number of controls who did not. Study Offers Little Support for an Old Drug 2014-08-11T04:00:00Z One possibility the researchers considered was that doctors might be more likely to prescribe digoxin to patients who are frail or more vulnerable to begin with. New Concerns About an Old Heart Drug 2014-08-11T04:00:00Z If markets function, the current high price of digoxin might induce some more drug companies to begin selling it, which should in turn bring prices back down. Some Generic Drug Prices Are Soaring 2014-07-08T04:00:00Z Bill Drilling, an owner of a pharmacy in Sioux City, Iowa, apologizes as he rings up a customer’s three-month supply of the heart medicine digoxin. Surprise! Generic-Drug Prices Spike 2013-12-12T23:41:25Z He thinks that clinical trials pitting digoxin against other treatments for atrial fibrillation are needed to settle the question. Heart Medication Digoxin Linked to Higher Risk of Death for Some 2014-08-11T04:00:00Z Some of his staff claimed he stopped bothering to use digoxin, but he denied that. Exclusive Excerpt: Gosnell Tries to Justify Crimes 2013-09-25T11:05:23Z “The atrial fibrillation patient community knows that digoxin is not a particularly good drug to be on,” she said. New Concerns About an Old Heart Drug 2014-08-11T04:00:00Z “I was so upset, I at first told the pharmacist I didn’t want it,” she said about her digoxin refill. Some Generic Drug Prices Are Soaring 2014-07-08T04:00:00Z The authors acknowledged that because they performed an observational study they were unable to demonstrate a direct cause-and-effect related to digoxin. Study Raises Questions About Digoxin Use Today 2013-09-24T15:10:00Z Cardiologists will recall that Haber’s 1982 NEJM digoxin trial was considered “negative” by many, even though digoxin significantly reduced hospitalizations in left heart failure patients, all because digoxin did not reduce mortality. New Actelion Drug Found Safe And Effective In Pulmonary Arterial Hypertension-- But Does It Save Lives? 2013-08-28T21:00:00Z But prosecutors said Gosnell did not always use digoxin and that it did not always work properly. Jury weighs murder charges against Philadelphia abortion doctor 2013-05-01T13:41:52Z A large percentage of these patients – nearly one in four – were prescribed digoxin to help control their atrial fibrillation. New Concerns About an Old Heart Drug 2014-08-11T04:00:00Z Though there are many newer types of drugs to treat heart disease, for some patients there are no effective substitutes; digoxin is on the World Health Organization’s list of Essential Medicines. Some Generic Drug Prices Are Soaring 2014-07-08T04:00:00Z He agrees with the study authors that it is time to “seriously question” the US and European guidelines that support the current use of digoxin. Study Raises Questions About Digoxin Use Today 2013-09-24T15:10:00Z "When you do non-randomized studies, you always wonder, was it really digoxin or was it the other confounders" such as patients' chronic diseases, that led to more deaths. Deaths more common on popular heart drug: study 2012-11-28T13:42:53Z The researchers say it is unclear precisely why digoxin is linked with deaths, but say the findings "call into question the widespread use of digoxin in AF patients". Safety of heart drug questioned 2012-11-28T07:50:30Z “I think the key message is that if patients are on digoxin, they need to be asking questions as to why,” she added. New Concerns About an Old Heart Drug 2014-08-11T04:00:00Z The company’s reported sales for cardiovascular products – its major drug in that category is digoxin -- rose to $16.9 million from $4.5 million in just a few months, according to company conference calls with investors. Some Generic Drug Prices Are Soaring 2014-07-08T04:00:00Z In an accompanying editorial, Lionel Opie writes that the new study “is of considerable importance” because the evidence base for the current use of digoxin is “highly unsatisfactory.” Study Raises Questions About Digoxin Use Today 2013-09-24T15:10:00Z More than two-thirds of the participants were treated with digoxin at some point either shortly before or during the 3.5-year study. Deaths more common on popular heart drug: study 2012-11-28T13:42:53Z Around half of these were prescribed digoxin while the others were given different heart medications or treatments. Safety of heart drug questioned 2012-11-28T07:50:30Z When I checked her meds, I found that the heart drug digoxin might be causing the problem and asked her doctor to change the medication. People's Pharmacy: Wife's estrogen cream's potential impact on husband 2012-08-01T20:17:08Z And while the average price tag at the pharmacy for a month of digoxin this year is still relatively cheap, about $50, he said, some patients are now encountering price tags of more than $1000. Some Generic Drug Prices Are Soaring 2014-07-08T04:00:00Z The heart drug digoxin, the blood thinner warfarin, the painkiller codeine and prednisone are considered mild anticholinergics. The Consumer: Cocktail of Popular Drugs May Cloud Brain 2012-02-27T22:43:46Z He said an earlier randomized controlled trial - considered the gold standard of medical research - did not find more deaths among people with heart failure taking digoxin. Deaths more common on popular heart drug: study 2012-11-28T13:42:53Z "Patients who are prescribed digoxin should not stop taking their meds without discussing their concerns with their doctor." Safety of heart drug questioned 2012-11-28T07:50:30Z She was taken off digoxin with no ill effects. People's Pharmacy: Wife's estrogen cream's potential impact on husband 2012-08-01T20:17:08Z The study can't prove that digoxin, also known as digitalis, actually causes breast cancer in some women. Heart drug linked to higher breast cancer risk 2011-03-22T21:27:57Z She is on doxazosin, furosemide, carvedilol, repaglinide, digoxin, warfarin, metformin, a beta blocker, a statin and allopurinol. People's Pharmacy: Natural sources of omega-3 fatty acids 2010-12-16T00:01:04Z Because the trial wasn't originally intended to measure the negative effects of digoxin, and people weren't assigned randomly to one arm or the other, the analysis also can't prove that digoxin caused the extra deaths. Deaths more common on popular heart drug: study 2012-11-28T13:42:53Z Heart patients should not be too alarmed by this study as digoxin is not the primary treatment for atrial fibrillation in the UK. Safety of heart drug questioned 2012-11-28T07:50:30Z Sometimes doctors don't have the specialized knowledge to recognize that a digoxin dose that was appropriate at 65 or 70 may be excessive in a 90-year-old. People's Pharmacy: Wife's estrogen cream's potential impact on husband 2012-08-01T20:17:08Z About 100,000 women age 20 and older took digoxin at some point during the course of the study, which tracked women for an average of 12 years. Heart drug linked to higher breast cancer risk 2011-03-22T21:27:57Z The combination of the diuretic furosemide with the heart medicine digoxin calls for extremely close monitoring of potassium and magnesium levels. People's Pharmacy: Natural sources of omega-3 fatty acids 2010-12-16T00:01:04Z But based on his team's study, he said he would recommend other heart medications before digoxin for people without heart failure. Deaths more common on popular heart drug: study 2012-11-28T13:42:53Z The herb has also been shown to interact with certain medications, including antidepressants, the heart medication digoxin and the blood thinner warfarin. 2010-01-15T15:15:00Z Loss of appetite, nausea and weight loss are classic symptoms of digoxin overdose, along with visual disturbances. People's Pharmacy: Wife's estrogen cream's potential impact on husband 2012-08-01T20:17:08Z About two percent of the women who took digoxin at any point during the new study eventually developed breast cancer. Heart drug linked to higher breast cancer risk 2011-03-22T21:27:57Z The chance of getting breast cancer was highest in women who were in their first year of taking digoxin. Heart drug linked to higher breast cancer risk 2011-03-22T21:27:57Z GlaxoSmithKline, which markets digoxin, was not available for immediate comment on the study. Heart drug linked to higher breast cancer risk 2011-03-22T21:27:57Z |
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