英语词汇“de novo”造句的方法、技巧、例句及翻译-英语例句辞典

Writing has evolved de novo only a few times in human history, in areas that had been the earliest sites of the rise of food production in their respective regions. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z

The mitochondria do not arise de novo in cells; they are always there, replicating on their own, independently of the replication of the cell. The Lives of a Cell 1974-01-01T00:00:00Z

Although it never seemed to be part of the conscious intention of either Jefferson or Madison at the time, the isolated location and de novo character of the national capital had even deeper political implications. Founding Brothers: The Revolutionary Generation 2000-10-17T00:00:00Z

The number of de novo copy number variations in someone’s DNA? Temple Grandin on DSM-5: “Sounds like diagnosis by committee” 2013-05-18T12:30:00Z

Rather than a pure robot civilization springing up de novo, it’s more likely that AI will integrate itself into things that already exist in our world. Our Evolutionary Past Can Teach Us about AI’s Future 2023-11-07T05:00:00Z

Many modern synthetic therapeutic drugs are derived or synthesized de novo from plant secondary metabolites. Fundamentals of Biology 2015-01-01T00:00:00Z

More ambitious programs are on the horizon, although it remains to be seen how soon the leap to de novo design—in which new proteins are built entirely from scratch—will come. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z

The study’s authors highlight 74 human protein genes that appear to have arisen in this de novo way—more than half of which emerged after the human lineage branched off from chimpanzees. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z

In seven of those cases, the mutation was de novo, meaning neither parent carries it—a finding that bolsters the case that it contributed to death. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z

At this moment, the helpful types of de novo proteins are attracting an increasing amount of scientific energy and expertise, and the molecules may be coming to a clinic near you. Artificial Proteins Never Seen in the Natural World Are Becoming New COVID Vaccines and Medicines 2021-06-22T04:00:00Z

The FDA signed off on the device using a process called a de novo classification. Birth control apps show the contradictions in FDA device oversight 2021-03-17T04:00:00Z

“If you are doing de novo, the real gold standard is not which architecture are you using—it’s what percentage of your designed proteins had the end desired property,” she says. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z

It “suggests that de novo gene birth may have played a role in human brain evolution.” Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z

In the 73 cases where DNA from both parents was available, they also looked across the exome for de novo variants. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z

The cancer-driving mutations found by the authors in scattered melanocytes might therefore represent the origins of some de novo melanomas. Seeds of cancer in normal skin 2020-10-06T04:00:00Z

But it’s not novel: Natural Cycles was already available when Clue came online, so it didn’t have to go through the de novo process either. Birth control apps show the contradictions in FDA device oversight 2021-03-17T04:00:00Z

But with the new Chroma algorithm, Grigoryan says that Generate is ready to embark on more ambitious projects, in which the algorithm can start building true de novo designs with user-designated structural and functional features. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z

Li’s team scoured the human and chimpanzee genomes for de novo protein-coding genes that had lncRNA counterparts in rhesus monkeys, as well as the crucial U1 element mutations needed to exit the nucleus. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z

Learning that the potential cause of a child’s death is a de novo variant could reassure parents that they’re unlikely to have passed a dangerous mutation to their other children, he says. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z

“The de novo review team unanimously agreed there is insufficient evidence to provide this case beyond a reasonable doubt,” Spitzer said. Charges against O.C. surgeon and girlfriend accused of drugging, assaulting women to be dropped 2020-02-04T05:00:00Z

Now, more and more examples are emerging of genes being created ‘de novo’ from barren stretches of the genome that do not code for any functional molecules. Daily briefing: Raw meat dog food can be bad for both canines and humans 2019-10-16T04:00:00Z

In the future, however, next-generation algorithms should make it possible to generate de novo proteins optimized to tick off many boxes on a scientist’s wish list rather than just one. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z

But she is more cautious about interpreting the role of de novo genes in brain evolution. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z

But researchers have yet to work out how to definitively identify a gene as being de novo, and questions still remain over exactly how — and how often — they are born. How evolution builds genes from scratch 2019-10-15T04:00:00Z

“The first clinical trials on de novo designed proteins are just starting,” Baker said. The ‘dawn’ of designer proteins: Biologists build a protein that turns cells on and off 2019-07-24T04:00:00Z

Researchers are trying to discover exactly how and why de novo genes are born. Daily briefing: Raw meat dog food can be bad for both canines and humans 2019-10-16T04:00:00Z

And de novo protein engineering often requires weeks of computational time and months of iteration. The computational protein designers 2019-07-22T04:00:00Z

The work suggests profoundly influential de novo genes might arise through subtle changes in their DNA sequence, Carvunis says, but there’s still much to be learned about how escaped lncRNAs eventually become true genes. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z

“You don’t have to go back that many years before de novo gene evolution was dismissed,” Baalsrud says. How evolution builds genes from scratch 2019-10-15T04:00:00Z

“It signals the dawn of de novo designer proteins,” said Ahmad Khalil, an associate professor of biomedical engineering at Boston University who was not involved with the research. The ‘dawn’ of designer proteins: Biologists build a protein that turns cells on and off 2019-07-24T04:00:00Z

The application of this method for designing ‘β-barrel’ proteins that bind small molecules is the first demonstration of the de novo design of both protein fold and function. 2018: Choice cuts from this year’s News & Views articles 2018-12-13T05:00:00Z

Although each de novo project in his lab is different, Baker says that they all follow the same basic strategy. The computational protein designers 2019-07-22T04:00:00Z

The results also suggest that increases in the de novo NAD+ synthesis pathway alone are sufficiently robust to ameliorate liver and kidney diseases associated with low NAD+ levels. Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z

Studies have also started to unpick what de novo genes do. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Historically, claiming something is “de novo” is a less common way of getting devices to market, but it’s becoming more popular, adds Speer, as we blend fitness gadgets with emerging technology. What the Apple Watch’s FDA clearance actually means 2018-09-13T04:00:00Z

At such an event last month Mr. Trump ordered the Pentagon to develop a de novo military branch dedicated to space. Houston, We Have a Space Force 2018-07-04T04:00:00Z

Each day of his presidency seems to arrive de novo, disconnected historically from the day before. Did an Ancient Greek Anticipate Trump? 2018-06-22T04:00:00Z

And why is the de novo pathway most active in organs involved in detoxification of the body in mammals? Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z

Studying de novo genes turns out to be part genetics, part thought experiment. How evolution builds genes from scratch 2019-10-15T04:00:00Z

One of the teams, led by Eichler, reported in October that they found ‘de novo’ mutations linked to autism in noncoding DNA. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z

If not, are the respondents entitled to a trial de novo with the protection of the rules of evidence? The Judge Will Hear Your 223,000 Excuses Now 2018-03-16T04:00:00Z

One analysis of families in Iceland showed that with each passing year, a man transmits an average of two more spontaneous, or de novo, mutations to his child. The link between autism and older parents is clear, but the why is not 2017-12-15T05:00:00Z

Given the enrichment of enzymes of the de novo pathway in the kidney and liver, this particular strategy also raises the intriguing possibility of tissue-specific NAD+ manipulation. Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z

Researchers studying the rice strain Oryza sativa japonica found 175 of its genes were created de novo.Credit: How evolution builds genes from scratch 2019-10-15T04:00:00Z

The study from the other team is in press, but found neither inherited nor de novo variants linked to autism in the regions. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z

A molecular network for de novo generation of the apical surface and lumen. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos 2017-11-28T05:00:00Z

A mathematical model of autism inheritance indicates that de novo mutations account for no more than 20 percent of the increased risk of autism among children of older fathers. The link between autism and older parents is clear, but the why is not 2017-12-15T05:00:00Z

The contribution of de novo coding mutations to autism spectrum disorder. Kctd13 deletion reduces synaptic transmission via increased RhoA 2017-10-31T04:00:00Z

Although de novo genes remain enigmatic, their existence makes one thing clear: evolution can readily make something from nothing. How evolution builds genes from scratch 2019-10-15T04:00:00Z

They did not identify any noninherited, or de novo, mutations linked to autism. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z

Men accumulate de novo mutations four times faster than women, the researchers found. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

Henderson wrote in his ruling that it is “not the responsibility, nor within the authority of, the Hearing Officer to conduct a de novo review of the case and second guess his decision.” Dallas Cowboys’ Ezekiel Elliott has six-game suspension upheld but is to play Sunday 2017-09-05T04:00:00Z

Moreover, some genetic conditions are the result of new, spontaneous changes in DNA, called “de novo” mutations. Perspective | Five myths about gene editing 2017-08-24T04:00:00Z

“One of the beauties of working with de novo genes,” says Casola, “is that it shows how dynamic genomes are.” How evolution builds genes from scratch 2019-10-15T04:00:00Z

To decipher ‘de novo’ signatures, we implemented and applied the method described previously52 to the mutational catalogue of each subgroup. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z

Maternal de novo mutations are especially concentrated in hotspots that comprise about 10 percent of the genome. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

Wigler’s team looked at simplex families and found rare de novo mutations in 27 genes. Using Big Data to Hack Autism 2017-07-06T04:00:00Z

To obtain final genomes for analysis, we pooled data from multiple replicates of a sample, de novo assembled, and scaffolded against KX197192.1. Zika virus evolution and spread in the Americas : Nature : Nature Research 2017-05-23T04:00:00Z

If nothing shows up, then it’s possible that the gene arose de novo. How evolution builds genes from scratch 2019-10-15T04:00:00Z

On the basis of the label positions on single DNA molecules, de novo assembly was performed by a pairwise comparison of all single molecules and graph building62. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z

“The de novo mutation rate in this part of the genome is almost twice what it is in the rest of the genome because of this big contribution from mothers,” Stefánsson says. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

Deploying statistical wizardry to combine the data on de novo and inherited mutations, along with CNV data from the Autism Genome Project, researchers pinpointed 65 genes and six CNVs as being key to autism. Using Big Data to Hack Autism 2017-07-06T04:00:00Z

However, mCRPC showed overwhelming de novo resistance to immune checkpoint blockade3, 4, 5, motivating a search for targeted therapies that overcome this resistance. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z

Many de novo genes remain uncharacterized, so the potential importance of the process to health and disease is unclear. How evolution builds genes from scratch 2019-10-15T04:00:00Z

In the final section, we consider the prospect of truly de novo catalyst design affecting the field of synthetic organic chemistry via the paradigm of transition-state recognition using π interactions as a design element. Exploiting non-covalent π interactions for catalyst design : Nature : Nature Research 2017-03-28T04:00:00Z

Stefánsson and his team are analyzing de novo mutations shared by siblings. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

In the second study, researchers screened for both inherited and de novo mutations and implicated 33 genes. Using Big Data to Hack Autism 2017-07-06T04:00:00Z

The final de novo assembly used only single molecules with a minimum length of 150 kb and eight labels per molecule. The genome of Chenopodium quinoa : Nature : Nature Research 2017-02-07T05:00:00Z

Counting de novo genes in the human genome comes with the same trail of caveats. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Given the seemingly sophisticated knowledge surrounding the physical underpinnings of each interaction discussed, one might inquire as to why genuine de novo design of catalysts for novel synthetic transformations is not commonplace. Exploiting non-covalent π interactions for catalyst design : Nature : Nature Research 2017-03-28T04:00:00Z

The results may help researchers determine the likelihood that the sibling of a child with a condition caused by de novo mutations will also carry the mutation. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

Their calculations indicated that common variants account for 49 percent of the risk for autism in the general population; rare variants, equal parts de novo and inherited, explain 6 percent. Using Big Data to Hack Autism 2017-07-06T04:00:00Z

Here we report the sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes. The seahorse genome and the evolution of its specialized morphology : Nature : Nature Research 2016-12-13T05:00:00Z

But where de novo genes have been identified, researchers are beginning to explore their roles in health and disease. How evolution builds genes from scratch 2019-10-15T04:00:00Z

EPA and the National Highway Traffic Safety Administration took the first step in this review—which they deemed a “de novo” rule-making—in July by publishing a draft technical assessment report for public review. The EPA’s Auto Outsourcing Act 2016-12-03T05:00:00Z

“My guess is, most of the age association is not explained by de novo mutations.” Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

In April 2007, Wigler and his then colleague, Jonathan Sebat, reported that ‘de novo’ mutations—those that arise spontaneously instead of being inherited—occur more often in people with autism than in typical people. Using Big Data to Hack Autism 2017-07-06T04:00:00Z

The cellular stress not only degrades the cell but also induces de novo aggregation85. The activities of amyloids from a structural perspective : Nature : Nature Research 2016-11-08T05:00:00Z

To trace which of an organism’s genes were made de novo, researchers need comprehensive sequences for the organism and its close relatives. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Flowchart of the data generation, processing and analysing for the de novo assembly and haplotype phasing of the AK1 diploid genome. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z

They found that mothers gain an average of 0.37 de novo mutations each year; fathers, by contrast, gain an average of 1.51 de novo mutations. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z

An appeal may be taken from the circuit court to the Arkansas Supreme Court, which shall likewise be tried de novo. Arkansas colleges live with legacy of 1942 vote 2016-03-07T05:00:00Z

The de novo assembly protocol was adapted from ref. The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea : Nature : Nature Publishing Group 2016-01-26T05:00:00Z

The rice study got around this by explicitly identifying the pieces of non-coding DNA that became de novo genes. How evolution builds genes from scratch 2019-10-15T04:00:00Z

This highly variable, complex region contained many SVs, making it difficult to phase against the reference genome, but allowed full resolution through the de novo approach. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z

A de novo approach to analysis would be preferable, but this would currently result in insertion and deletion errors due to poor resolution of homopolymeric tracts on the MinION. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z

Unfortunately, deciphering the function of de novo genes is far more difficult than identifying them. A Surprise Source of Life's Code 2015-08-31T04:00:00Z

Because a de novo assembly still generates many spurious transcripts, we used the transcript expression value to remove low quality contigs. The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea : Nature : Nature Publishing Group 2016-01-26T05:00:00Z

For Zhang, research that links de novo genes to the human brain is tantalizing. How evolution builds genes from scratch 2019-10-15T04:00:00Z

The optical maps were assembled de novo into genome maps. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z

We compared the de novo assembled RNA-seq output to the genome to evaluate the completeness of the genome assembly. The octopus genome and the evolution of cephalopod neural and morphological novelties : Nature : Nature Publishing Group 2015-08-11T04:00:00Z

Scientists also want to understand how de novo genes get incorporated into the complex network of reactions that drive the cell, a particularly puzzling problem. A Surprise Source of Life's Code 2015-08-31T04:00:00Z

The Commissioners review the record and decide the case de novo, in other words with no deference to any of the ALJ’s rulings. The Real Problem With SEC Administrative Proceedings, and How To Fix It 2015-07-20T04:00:00Z

One option for finding candidate de novo genes is to use an algorithm to search for similar genes in related species. How evolution builds genes from scratch 2019-10-15T04:00:00Z

It was hardly a theory I developed de novo, but rather is one many researchers had voiced—thought not yet proven. Why Men Are More Narcissistic Than Women 2015-03-05T05:00:00Z

Evidence suggests that a portion of de novo genes quickly become essential. A Surprise Source of Life's Code 2015-08-31T04:00:00Z

Circuit held that it would have concluded that the ads were deceptive even had it chosen to apply a de novo standard of review to the FTC’s findings. The D.C. Circuit's POM Wonderful Decision: Not So Wonderful For FTC's Randomized Clinical Trial Push 2015-02-04T05:00:00Z

In the past five years, researchers have found numerous signs of these newly minted ‘de novo’ genes in every lineage they have surveyed. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Court of Appeals for the Federal Circuit subjected a lower court’s ruling to a top-to-bottom de novo review. Supreme Court Hands Trial Courts More Power In Teva Patent Case 2015-01-20T05:00:00Z

As a result, the number of de novo genes might explode. A Surprise Source of Life's Code 2015-08-31T04:00:00Z

To compare mouse and human regulatory networks, we applied the de novo motif discovery approach that we developed previously28 and obtained a list of high-confidence sequence motifs using the ChIP-seq data sets. Principles of regulatory information conservation between mouse and human : Nature : Nature Publishing Group 2014-11-18T05:00:00Z

Gene duplication is a “very conservative mechanism” she says, producing well-adapted proteins cut from the same cloth as their ancestors; de novo genes, by contrast, are likely to produce markedly different molecules. How evolution builds genes from scratch 2019-10-15T04:00:00Z

We performed phasing against the de novo assembly. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z

The mutations they discovered in the autistic children were dubbed de novo, after the Latin term for “afresh.” Autism Could Be Caused by Genetic Mutations in Over 100 Genes, According to New Research

“The existence of de novo genes was supposed to be a rare thing,” said Mar Albà, an evolutionary biologist at the Hospital del Mar Research Institute in Barcelona, who presented the research. A Surprise Source of Life's Code 2015-08-31T04:00:00Z

I contemplated using my machine, together with well-known biotechnical methods, to create, de novo, the H.I.V. genome — an actual molecule identical to that found in H.I.V. viruses living in the wild. Resurrecting Smallpox? Easier Than You Think 2014-10-15T04:00:00Z

Long’s team wanted to know how many genes had emerged de novo in the strain Oryza sativa japonica, and what proteins those genes might be making. How evolution builds genes from scratch 2019-10-15T04:00:00Z

One can’t conduct de novo review of a nullity, the oil company maintained. Chevron Defends Its RICO Victory in the Epic Ecuadorian Oil Pollution Case 2014-10-03T04:00:00Z

Genes with loss-of-function de novo mutations are underlined and in italics. Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group 2014-07-21T04:00:00Z

The results suggest that roughly 49 percent of the risk of developing autism can be attributed to common variants, versus 3 percent for rare, de novo variants. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z

Prior to issuing its approval, the governmental agency subjected ReWalk through its de novo classification process, which is used for "first-of-its-kind medical devices." ReWalk bionic suit can now be sold in the US 2014-06-27T04:00:00Z

The study gets at one of the field’s biggest preoccupations: how to tell whether a gene is truly de novo. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Ecuador’s system is different, however, and appellate courts there do engage in what’s known as de novo review of the facts. Chevron Defends Its RICO Victory in the Epic Ecuadorian Oil Pollution Case 2014-10-03T04:00:00Z

The expected test statistics are calculated by averaging over 50,000 permuted de novo mutation sets. Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group 2014-07-21T04:00:00Z

“The inter-relationship between common and rare variation and inherited and de novo variation is going to be the big thing for the next few years,” he says. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z

Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. [Research Articles] An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss 2014-04-30T18:55:14.141Z

For example, an early study found 15 de novo genes in the whole primate order10; a later attempt found 60 in humans alone11. How evolution builds genes from scratch 2019-10-15T04:00:00Z

Dr. Begun and his colleagues are now getting a look at these early stages in the birth of de novo genes. The Continuing Evolution of Genes 2014-04-28T21:20:18Z

For cases in which there is a single affected proband and no family history, investigators should consider sequencing the unaffected parents of the probands, permitting efficient discovery of de novo mutations and compound heterozygous genotypes. Guidelines for investigating causality of sequence variants in human disease 2014-04-23T17:21:03.147Z

Spontaneous risk The new study also calculated the contribution of de novo mutations—which are not included in estimates of inherited risk—at about 3 percent. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z

Next we investigated whether de novo endoderm differentiation was preceded by a pluripotent state. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z

Studies suggest that the cells’ repeated reproductions lead to the accumulation of random errors over time, called de novo mutations. Mental Illness Risk Higher for Children of Older Parents, Study Finds 2014-02-26T21:00:02Z

Far from being a fluke, these studies suggest that de novo genes are abundant. The Continuing Evolution of Genes 2014-04-28T21:20:18Z

We consider a single gene as the fundamental unit for monogenic disease gene testing, for all disease models; a disease caused by de novo mutations or a disease caused by inherited dominant or recessive variants. Guidelines for investigating causality of sequence variants in human disease 2014-04-23T17:21:03.147Z

Much of autism research so far has focused on rare, de novo mutations, which appear spontaneously in individuals with autism. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z

However, the origin and spread of these de novo genes within populations remain obscure. [Report] Origin and Spread of de Novo Genes in Drosophila melanogaster Populations 2014-02-13T19:25:57.434Z

To what extent does adaptation rely on de novo mutation, as opposed to preexisting variation? [Report] Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish 2013-12-12T19:26:55.319Z

Dr. Schlötterer and his colleagues found the answer in their study: Along each lineage, many de novo genes are also lost. The Continuing Evolution of Genes 2014-04-28T21:20:18Z

The acquisition of de novo mutations might enhance the cells' therapy resistance, enabling the tumour to relapse and the disease to progress. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z

It descends in families, rarely arising de novo. Former TV reporter campaigns to bring Huntington’s disease out of the shadows 2013-07-29T22:24:55Z

This functionally links decreased de novo SL synthesis to asthma and so identifies this metabolic pathway as a potential target for therapeutic interventions. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z

Repeat sequences were identified by combining de novo approaches and sequence similarity at the nucleotide and protein levels. Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation 2013-04-03T17:22:05.187Z

Dr. Begun and his colleagues renamed orphan genes “de novo genes,” from the Latin for new. The Continuing Evolution of Genes 2014-04-28T21:20:18Z

Healy, it was pointed out in the judgment, did not request a de novo hearing at the appeal. Teams make the scrum a problem by bypassing rugby rulemakers' changes 2013-03-28T12:42:33Z

The present study analyzes the effect of decreased de novo SL synthesis in the lung on airway reactivity after administration of myriocin, an inhibitor of SPT, and in SPT heterozygous knockout mice. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z

We expect growth in de novo clinics to be funded internally. TEXT-S&P rates ATI Holdings 'B', outlook stable; new debt rated 2013-01-11T15:50:28Z

Dr. Begun suspects that the true number of de novo genes in the flies is higher. The Continuing Evolution of Genes 2014-04-28T21:20:18Z

Only a small number of de novo genetic variants were detected in serially transplanted tumours compared with primary patient samples. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z

We see mosaics, balanced de novo translocations, inversions, marker chromosomes … the frequency of all of those is about 1 percent,” Ronald Wapner, MD, told me. The Battle of the Prenatal Tests 2012-12-05T23:15:04.403Z

We show that, in both models, decreased de novo SL synthesis increases bronchial reactivity in the absence of inflammation. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z

She is missing material on her fourth chromosome, a de novo deletion, meaning it was just a random deletion, not something she inherited. The Trouble with My Daughter's DNA 2012-10-28T21:05:21Z

Gene models were obtained by integrating results of de novo gene prediction and alignment-based methods based on homology and transcriptomic evidence. The oyster genome reveals stress adaptation and complexity of shell formation 2012-10-03T18:22:26.103Z

When the dominant pretherapy clone remains dominant after relapse, the dominant clone often gains de novo mutations. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z

But unlike his and Laurie’s situation, their inversion was “de novo.” The Battle of the Prenatal Tests 2012-12-05T23:15:04.403Z

Consequently, applying de novo motif discovery to the footprint compartments gleaned from multiple cell types should greatly expand our current knowledge of biologically active transcription factor binding motifs. An expansive human regulatory lexicon encoded in transcription factor footprints 2012-09-05T17:21:56.447Z

Dr. Stefansson said that it made sense that de novo mutations would play a significant role in brain disorders. Father’s Age Is Linked to Risk of Autism and Schizophrenia 2012-08-22T17:18:06Z

Although using pedigree information or combining it with population data provides further phasing power, no combination of these methods is able to resolve de novo mutations. Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells 2012-07-11T17:21:04.120Z

We have developed a de novo reference genome sequence that will facilitate evolutionary and ecological studies in this key group of butterflies. Butterfly genome reveals promiscuous exchange of mimicry adaptations among species 2012-07-04T17:21:31.773Z

They also managed to detect 39 of 44 de novo mutations in the fetus, but with false positives. Fetal Genome Deduced from Parental DNA 2012-06-07T22:15:00.207Z

They found that the prenatal reconstruction was more than 98% accurate when compared to the actual postnatal sequence, although it missed five de novo mutations. Decoding an Unborn Baby's DNA: Should We Worry or Celebrate? 2012-06-06T23:36:28Z

Furthermore, 39 of 44 de novo point mutations in the fetal genome were detected, albeit with limited specificity. [Research Articles] Noninvasive Whole-Genome Sequencing of a Human Fetus 2012-06-06T19:25:14.950Z

For the initial child in the study, 44 de novo mutations were identified after birth -- none of which were anticipated to cause severe disease. Sequencing the Unborn 2012-06-06T19:00:00Z

In an analysis of 51 de novo mutations, Dr. Eichler’s group found that glitches were four times more likely to originate in DNA from the male than from the female. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-05T19:52:27Z

Further analysis, drawing on data from a larger sample, turned up two more genes disrupted by multiple de novo glitches, also named by Daly's group. Rare gene mutations increase autism risk, studies say 2012-04-05T00:26:03Z

They identified 125 de novo mutations that would change the readout of genes among the children with autism and 87 among their unaffected siblings. Researchers Find Gene Mutations That May Be a Key to Autism 2012-04-04T18:00:00Z

Although technical and analytical challenges remain, we anticipate that noninvasive analysis of inherited variation and de novo mutations in fetal genomes will facilitate prenatal diagnosis of both recessive and dominant Mendelian disorders. [Research Articles] Noninvasive Whole-Genome Sequencing of a Human Fetus 2012-06-06T19:25:14.950Z

Further analysis, drawing on data from a larger sample, turned up two more genes disrupted by multiple de novo glitches, also named by Dr. Daly’s group. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-04T17:45:44Z

All three studies also found evidence that the risk of de novo mutations increases with parental age. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-05T19:52:27Z

It is an attempt to start de novo with certain concepts of society and government. The Political Doctrines of Sun Yat-sen: An Exposition of the San Min Chu I 2012-04-04T02:00:55.303Z

Eichler's team also found that de novo mutations were four times as likely to lie on DNA strands inherited from the father, and that the number of mutations increases with paternal age. Researchers Find Gene Mutations That May Be a Key to Autism 2012-04-04T18:00:00Z

It would not be more wonderful, de novo, than the discovery of the lightning-rod, or navigation by steam! Pencillings by the Way Written During Some Years of Residence and Travel in Europe 2012-03-19T02:00:26.650Z

Is it, in other words, ever generated de novo? A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z

The productive powers of the land become exhausted in a few years, when the clearing is abandoned, a new site is chosen, and the same operations are carried on de novo. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 9 "Dagupan" to "David" 2012-02-11T03:03:39.807Z

By this time too it was realized that the formation of cells de novo, postulated by Schleiden’s theory of “phytogenesis,” did not occur. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 8 "Cube" to "Daguerre, Louis" 2012-01-31T03:00:17.257Z

"The time to generation of a virus by de novo engineering from raw sequence data is probably longer than the age-old method of virus passage in mammals/mammalian cells." Prominent Virologists Want U.S. Advisory Board to Take a Second Look at Controversial Flu Papers 2012-01-20T16:44:14Z

This idea began to change in 2002, when the poliovirus was synthesized de novo. Preventing pandemics: The fight over flu 2012-01-18T18:20:33.007Z

There are no sustained observations which prove that yellow-fever poison is ever created de novo. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z

Consequently, the agreement was held to be vitiated, and the legal proceedings had to be recommenced de novo. Legal Lore Curiosities of Law and Lawyers 2012-01-17T03:00:20.443Z

It is, of course, impossible for any organism, however small, to create itself de novo. The Fijians A Study of the Decay of Custom 2011-12-30T03:00:25.917Z

Well, let us get back to Ward and begin de novo. Why Lincoln Laughed 2011-12-29T03:00:17.037Z

The nets are hauled in, the fish flung out on the river banks, and the same process begins de novo. Alone with the Hairy Ainu or, 3,800 miles on a pack saddle in Yezo and a cruise to the Kurile Islands. 2011-10-30T02:00:10.270Z

Whereas many countries will adopt similar standards rather than developing them de novo, the variety of perspectives dictates that in respect for others we must accept a variety of regulatory solutions. Should Scientists Use Genetically Modified Insects to Fight Disease? 2011-10-24T15:15:00.253Z

Another set of compounds are designed completely de novo, based on knowledge of the target site. Lunchtime science 2011-10-12T17:20:55.227Z

At the close of the year Paine wrote the whole work de novo. The Life Of Thomas Paine, Vol. II. (of II) With A History of His Literary, Political and Religious Career in America France, and England 2011-10-12T02:00:47.957Z

It is quite a mistake to suppose that he had to begin de novo, and to re-establish Paganism. Sermons 2011-09-26T02:00:27.830Z

Secondly, the human mind does not at any time commence its philosophic speculations de novo. Determinism or Free-Will? 2011-09-10T02:00:27.557Z

These he worked upon, de novo, during the long recess, and ‘rich and rare’ indeed was the collection; it was the poor messenger’s only comfort. Nicotiana Or The Smoker's and Snuff-Taker's Companion 2011-07-29T02:00:29.353Z

However, none of them produced de novo DNA sequence, addressed the issue of delivering template DNA to the sensors, or scaled to large arrays. An integrated semiconductor device enabling non-optical genome sequencing 2011-07-20T17:20:42.953Z

It is apparently the sole work which he ever wrote, created de novo and without the data having been found or brought to him from without. Concerning Lafcadio Hearn With a Bibliography by Laura Stedman 2011-07-20T02:00:12.413Z

It's a lot easier to gain people's trust de novo than to try and regain after you've lost it. CIA's Fake Vaccination Drive Angers Public Health World 2011-07-13T20:39:05Z

Improved assembly algorithms, increased read lengths, and de novo sequences of additional haplotypes will reveal the full catalogue of genes critical to inbreeding depression. Genome sequence and analysis of the tuber crop potato 2011-07-13T17:21:42.673Z

“We frankly don't understand biology well enough to start designing genomes de novo.” Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z

As is well known, a language is not created de novo, but by a slow process of development. North America 2011-05-05T02:00:20.027Z

The need was for scientific standpoints to be investigated de novo; and the process had, as a matter of fact, already been begun on the Continent. Religion and Science From Galileo to Bergson 2011-04-07T02:00:16.760Z

It would certainly be impossible if we had to begin de novo to construct the whole fabric of economic science. Encyclopaedia Britannica, 11th Edition, Volume 8, Slice 10 "Echinoderma" to "Edward" 2011-01-19T03:00:19.027Z

Such “copy number variants” may occur de novo in apparently sporadic cases of schizophrenia or autism. Slipping the 'Cognitive Straitjacket' of Psychiatric Diagnosis 2011-01-04T16:17:14.270Z

They will look at the case de novo, that is, anew, and won't need to show any deference to his legal conclusions. Why California's Prop 8 Against Gay Marriage Was Struck Down 2010-08-05T08:35:00Z

We are not made so that we can invent everything de novo, or escape the effect on our minds of what has preceded us; the attempt can only lead to baldness or eccentricity. Encyclopaedia Britannica, 11th Edition, Volume 2, Slice 4 "Aram, Eugene" to "Arcueil"

He at once set about organizing that department de novo. The History of Cuba, vol. 4

The question remained whether this product was generated de novo. History of Phosphorus

It is difficult to believe that it was constructed de novo, or all at one time. The Towns of Roman Britain

Absence of capital, of concentrated wealth, made it necessary to begin de novo. The Galaxy, April, 1877 Vol. XXIII.—April, 1877.—No. 4.

The production of rocks de novo upon the earth's surface. The Coming of Evolution The Story of a Great Revolution in Science

As the Lords had thrown out the Reform Bill, it was necessary to A Dead Lock. begin de novo. English Caricaturists and Graphic Humourists of the Nineteenth Century. How they Illustrated and Interpreted their Times.

Organisms representing previous thoughts will be added to, in order to express the expansion of the thought, instead of a creation de novo in each instance. The Philosophy of Evolution Together With a Preliminary Essay on The Metaphysical Basis of Science

As a primary consideration any condition which lowers the vitality or vigor of the calf must be accorded a prominent place among factors which, apart from contagion, contribute to start the disease de novo. Special Report on Diseases of Cattle

They did not make offices absolutely de novo, but they did condense and combine old offices in a manner that practically made a new thing of them. A Short History of the Book of Common Prayer

Doubtless, therefore, without either production of microcytes or production de novo, the number of red corpuscles in capillary blood may undergo considerable variations. Histology of the Blood Normal and Pathological

If they had concurred in reversing the judgment which disallowed the challenge to the array, the only effect would have been, to order a venire de novo, or a new trial. Blackwood's Edinburgh Magazine, Volume 56, Number 349, November, 1844

In the illustration above we have assumed that a monopoly was starting de novo. The Evolution of Modern Capitalism A Study of Machine Production

This progressive development of nature and humanity has not been a series of creations de novo, without any relation, in matter or form, to that which preceded. Christianity and Greek Philosophy or, the relation between spontaneous and reflective thought in Greece and the positive teaching of Christ and His Apostles

It is the failure to observe this plain canon of style that has made shipwreck of many an attempt to construct liturgies de novo. A Short History of the Book of Common Prayer

The new moon is considered pre-eminently auspicious for commencements,--for all kinds of building up, and beginning de novo. Moon Lore

A new language arising with any people de novo can nowhere be found. The New Avatar and The Destiny of the Soul The Findings of Natural Science Reduced to Practical Studies in Psychology

If changed, she must be registered de novo, and the old certificate cancelled. The Sailor's Word-Book An Alphabetical Digest of Nautical Terms, including Some More Especially Military and Scientific, but Useful to Seamen; as well as Archaisms of Early Voyagers, etc.

Although he had been told that it would be so, he did not realise until that moment that the trial would have to commence de novo. The Day of Judgment

I have to begin de novo, and perhaps can't take into account all the forces which have been growing up through the ages. "The Pomp of Yesterday"

He did not see me, and I was not anxious to begin de novo the disagreeable discussion of the morning. Blackwood's Edinburgh Magazine - Volume 55, No. 343, May 1844

According to them, the contagia of epidemic disease are formed de novo in a putrescent atmosphere. Fragments of science, V. 1-2

Childhood impressions are ever the most lasting, and so long as one-half of the Orient remained untouched by progressive influences Oriental progress had to be begun again de novo with every succeeding generation. The New World of Islam

Speaking generally, we may say that no word is ever created de novo. The Romance of Words (4th ed.)

I have to be always beginning de novo. "The Pomp of Yesterday"

Said or not said, let us presume it unsaid, and let me state the true answer as if de novo, even if by accident somewhere the darkness shelters this same answer as uttered long ago. The Posthumous Works of Thomas De Quincey, Vol. 1

In the words of Dr. Bastian: 'We can only infer that whilst the boiled saline solution is quite incapable of engendering bacteria, such organisms are able to arise de novo in the boiled organic infusion.' Fragments of science, V. 1-2

After it had been written as usual, twice over, we kept it by us, bringing it out from time to time, and going through it "de novo," reading, weighing and criticizing every sentence. Little Journeys to the Homes of the Great - Volume 13 Little Journeys to the Homes of Great Lovers

But by the time that he has just disenthralled himself, he is removed, and another appointed in his place, and the work has to commence de novo. Diary in America, Series Two

Only Greek science, and the scientific spirit, were almost completely lost, and a beginning de novo had to be made when the West shook off its fetters. The Legacy of Greece Essays By: Gilbert Murray, W. R. Inge, J. Burnet, Sir T. L. Heath, D'arcy W. Thompson, Charles Singer, R. W. Livingston, A. Toynbee, A. E. Zimmern, Percy Gardner, Sir Reginald Blomfield

Freedom and initiative never begin entirely de novo. Christianity and Ethics A Handbook of Christian Ethics

The inference just referred to is completely disposed of by the simple question: 'Why, when your sterilised organic infusion is exposed to optically puree air, should this generation of life de novo utterly cease? Fragments of science, V. 1-2

The mosquito, of course, criminal as she is, does not hatch the parasites de novo in her own body, but simply sucks them up in a meal of blood from some previous victim. Preventable Diseases

The discordant tones of the violin, as the new string was tortured into tune, once more opened the safety-valve, and the ball began de novo. Hudson Bay

He objects on principle to the origin of organs de novo. Form and Function A Contribution to the History of Animal Morphology

Anthropology needs trained devotees with philosophic methods and keen observation to study every tribe and nation of the globe almost de novo; and from, materials thus collected a science may be established. On Limitations To The Use Of Some Anthropologic Data

Life cannot supply energy de novo, cannot create it out of nothing, but it can and must draw upon the store of energy in which the earth floats as in a sea. The Breath of Life

They sold out the farm they put in shape, after two years' work, for just ten times what it had cost, and they are now starting another one de novo. The Life and Letters of Walter H. Page, Volume I

It seems to me, therefore, that in seeking to estimate the evidence of design in Nature, we must as it were start de novo, without reference to anterior beliefs upon the subject. Thoughts on Religion

So that doubting concerning the Eternity of the World, and its Existence de novo, did him no harm at all. The Improvement of Human Reason Exhibited in the Life of Hai Ebn Yokdhan

Mohamad says that he will not return to Casembe again, but will begin to trade with some other chief: it is rather hard for a man at his age to begin de novo. The Last Journals of David Livingstone, in Central Africa, from 1865 to His Death, Volume I (of 2), 1866-1868

The feeling was so strong that many were prepared to abandon the whole scheme and start de novo rather than continue an undertaking in which it looked as though they were being fooled. The Transvaal from Within A Private Record of Public Affairs

The world was to be turned topsy-turvy; and poetry, by the good will of our Adam-wits, was to share its fate and begin de novo. Lectures on the English Poets Delivered at the Surrey Institution

Furthermore we decree that Doctors, lecturing ordinarily or extraordinarily, must come to the sections assigned de novo, according to the regulations below. Readings in the History of Education Mediaeval Universities

Mr. Hogarth, indeed, concludes that 'it is hopeless now to sift his work; those who would treat the site of Alexandria scientifically must ignore him and start de novo'. Ancient Town-Planning

Do they spring up de novo from the highest point on the area of not-life, which they touch? Scientific American Supplement, No. 470, January 3, 1885

The ceremony was prepared de novo for the occasion and the pledges were mutual. Evolution Of The Japanese, Social And Psychic

He may take his chances of success in the Land Office, and if at any time he becomes apprehensive of an adverse decision he may begin de novo in the courts. A Compilation of the Messages and Papers of the Presidents Volume 9, part 1: Benjamin Harrison

Out of this vast sea of mud Nature has had to evolve another creation, beginning de novo, with her lowest forms. The Collected Works of Ambrose Bierce, Volume 1

The impressions, ‘laid up in the brain, will be reversed back to the retiform coat and crystalline humour,’ hence ‘a lively seeing, as if, de novo, the object had been placed before the eye’. Cock Lane and Common-Sense

A trenchant and resolute advocate of the origin of living forms de novo has published what he considers a crucial illustration in support of his case. Scientific American Supplement, No. 470, January 3, 1885

In this case, the proceedings on the trial will be commenced de novo, if the reference has been made on the ground of any informality or illegality in the previous trial. The Principles of Masonic Law A Treatise on the Constitutional Laws, Usages and Landmarks of Freemasonry

Nothing can be done de novo; a fresh beginning cannot be had. George Eliot; a Critical Study of Her Life, Writings & Philosophy

Now here also, as in His teaching about God, Christ did not need to begin de novo. The Teaching of Jesus

The "vocabulary of Chippewa," so far as it is Chippewa at all, has the French or a mixed orthography, which it is not probable that an Englishman or an American would, de novo, employ. Personal Memoirs of a Residence of Thirty Years with the Indian Tribes on the American Frontiers

It is taken up de novo by some inventor, stimulated by the needs of his time, and falling again upon the track, he recovers the old footmarks, follows them up, and completes the work. Industrial Biography, Iron Workers and Tool Makers

If Mr. Forrest in former days established his fame as an explorer, his late expedition only proves that he must commence de novo. Explorations in Australia, Illustrated,

The necessary chemical re-agents to reproduce life, as well as the necessary processes of producing it de novo have not yet been ascertained, nor is it likely they ever will be. Life: Its True Genesis

Christ, we must remember, did not, in His teaching, begin de novo. The Teaching of Jesus

Now in the contents of the pamphlet I read: 'Small-pox—never produced at present de novo.'… Memoir and Letters of Francis W. Newman

After it had been written as usual twice over, we kept it by us, bringing it out from time to time, and going through it de novo, reading, weighing, and criticizing every sentence. Autobiography

It was necessary to commence de novo, but this could no longer be done with the first course, which was removed, and Aristabulus set-to, with zeal, forthwith, on the game. Home as Found

Professor Bastian thinks he has conclusive evidence that what he calls "new-born specks of living matter" are produced de novo, that is, independently of any conceivable germ or germinal principle of life implanted in nature. Life: Its True Genesis

In any new life of Swift the case must be stated de novo. Note Book of an English Opium-Eater

One dare affirm that man cannot create life de novo any more than he can create matter. Time and Change

But-"qui se dispute, s'adore"-when we again met all would be forgotten, and the old tale be told over de novo. Personal Narrative of a Pilgrimage to Al-Madinah & Meccah — Volume 1

On the other hand, malignant endocarditis may apparently develop de novo. Disturbances of the Heart

His flask experiments, therefore, prove nothing; and all this talk about de novo production is the sheerest scientific delusion. Life: Its True Genesis

Talking of "natural selection;" if I had to commence de novo, I would have used "natural preservation." Life and Letters of Charles Darwin — Volume 2

Through his knowledge and his science man performs wonders every day; he can reduce mountains to powder and seas to dry land, but he cannot create or start de novo the least throb of life. Time and Change

There is a truth, however, in De Maistre's doctrine that constitutions are generated, or developed, not created de novo, or made all at once. The American Republic : constitution, tendencies and destiny

Towards 1870 it was first demonstrated that cell-nuclei do not arise de novo, but are invariably the result of division of pre-existing nuclei. Darwin and Modern Science

Both are essentially endowed with the same potentiality of originating life independently of vital units, or de novo, as they more persistently phrase it. Life: Its True Genesis

Each seems to think that the whole subject should begin de novo because he has asked for information. The New Revelation

单词	de novo
例句	de novo Writing has evolved de novo only a few times in human history, in areas that had been the earliest sites of the rise of food production in their respective regions. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z The mitochondria do not arise de novo in cells; they are always there, replicating on their own, independently of the replication of the cell. The Lives of a Cell 1974-01-01T00:00:00Z Although it never seemed to be part of the conscious intention of either Jefferson or Madison at the time, the isolated location and de novo character of the national capital had even deeper political implications. Founding Brothers: The Revolutionary Generation 2000-10-17T00:00:00Z The number of de novo copy number variations in someone’s DNA? Temple Grandin on DSM-5: “Sounds like diagnosis by committee” 2013-05-18T12:30:00Z Rather than a pure robot civilization springing up de novo, it’s more likely that AI will integrate itself into things that already exist in our world. Our Evolutionary Past Can Teach Us about AI’s Future 2023-11-07T05:00:00Z Many modern synthetic therapeutic drugs are derived or synthesized de novo from plant secondary metabolites. Fundamentals of Biology 2015-01-01T00:00:00Z More ambitious programs are on the horizon, although it remains to be seen how soon the leap to de novo design—in which new proteins are built entirely from scratch—will come. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z The study’s authors highlight 74 human protein genes that appear to have arisen in this de novo way—more than half of which emerged after the human lineage branched off from chimpanzees. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z In seven of those cases, the mutation was de novo, meaning neither parent carries it—a finding that bolsters the case that it contributed to death. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z At this moment, the helpful types of de novo proteins are attracting an increasing amount of scientific energy and expertise, and the molecules may be coming to a clinic near you. Artificial Proteins Never Seen in the Natural World Are Becoming New COVID Vaccines and Medicines 2021-06-22T04:00:00Z The FDA signed off on the device using a process called a de novo classification. Birth control apps show the contradictions in FDA device oversight 2021-03-17T04:00:00Z “If you are doing de novo, the real gold standard is not which architecture are you using—it’s what percentage of your designed proteins had the end desired property,” she says. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z It “suggests that de novo gene birth may have played a role in human brain evolution.” Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z In the 73 cases where DNA from both parents was available, they also looked across the exome for de novo variants. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z The cancer-driving mutations found by the authors in scattered melanocytes might therefore represent the origins of some de novo melanomas. Seeds of cancer in normal skin 2020-10-06T04:00:00Z But it’s not novel: Natural Cycles was already available when Clue came online, so it didn’t have to go through the de novo process either. Birth control apps show the contradictions in FDA device oversight 2021-03-17T04:00:00Z But with the new Chroma algorithm, Grigoryan says that Generate is ready to embark on more ambitious projects, in which the algorithm can start building true de novo designs with user-designated structural and functional features. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z Li’s team scoured the human and chimpanzee genomes for de novo protein-coding genes that had lncRNA counterparts in rhesus monkeys, as well as the crucial U1 element mutations needed to exit the nucleus. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z Learning that the potential cause of a child’s death is a de novo variant could reassure parents that they’re unlikely to have passed a dangerous mutation to their other children, he says. Geneticists find clues to sudden unexplained child deaths 2022-02-09T05:00:00Z “The de novo review team unanimously agreed there is insufficient evidence to provide this case beyond a reasonable doubt,” Spitzer said. Charges against O.C. surgeon and girlfriend accused of drugging, assaulting women to be dropped 2020-02-04T05:00:00Z Now, more and more examples are emerging of genes being created ‘de novo’ from barren stretches of the genome that do not code for any functional molecules. Daily briefing: Raw meat dog food can be bad for both canines and humans 2019-10-16T04:00:00Z In the future, however, next-generation algorithms should make it possible to generate de novo proteins optimized to tick off many boxes on a scientist’s wish list rather than just one. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z But she is more cautious about interpreting the role of de novo genes in brain evolution. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z But researchers have yet to work out how to definitively identify a gene as being de novo, and questions still remain over exactly how — and how often — they are born. How evolution builds genes from scratch 2019-10-15T04:00:00Z “The first clinical trials on de novo designed proteins are just starting,” Baker said. The ‘dawn’ of designer proteins: Biologists build a protein that turns cells on and off 2019-07-24T04:00:00Z Researchers are trying to discover exactly how and why de novo genes are born. Daily briefing: Raw meat dog food can be bad for both canines and humans 2019-10-16T04:00:00Z And de novo protein engineering often requires weeks of computational time and months of iteration. The computational protein designers 2019-07-22T04:00:00Z The work suggests profoundly influential de novo genes might arise through subtle changes in their DNA sequence, Carvunis says, but there’s still much to be learned about how escaped lncRNAs eventually become true genes. Human gene linked to bigger brains was born from seemingly useless DNA 2023-01-05T05:00:00Z “You don’t have to go back that many years before de novo gene evolution was dismissed,” Baalsrud says. How evolution builds genes from scratch 2019-10-15T04:00:00Z “It signals the dawn of de novo designer proteins,” said Ahmad Khalil, an associate professor of biomedical engineering at Boston University who was not involved with the research. The ‘dawn’ of designer proteins: Biologists build a protein that turns cells on and off 2019-07-24T04:00:00Z The application of this method for designing ‘β-barrel’ proteins that bind small molecules is the first demonstration of the de novo design of both protein fold and function. 2018: Choice cuts from this year’s News & Views articles 2018-12-13T05:00:00Z Although each de novo project in his lab is different, Baker says that they all follow the same basic strategy. The computational protein designers 2019-07-22T04:00:00Z The results also suggest that increases in the de novo NAD+ synthesis pathway alone are sufficiently robust to ameliorate liver and kidney diseases associated with low NAD+ levels. Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z Studies have also started to unpick what de novo genes do. How evolution builds genes from scratch 2019-10-15T04:00:00Z Historically, claiming something is “de novo” is a less common way of getting devices to market, but it’s becoming more popular, adds Speer, as we blend fitness gadgets with emerging technology. What the Apple Watch’s FDA clearance actually means 2018-09-13T04:00:00Z At such an event last month Mr. Trump ordered the Pentagon to develop a de novo military branch dedicated to space. Houston, We Have a Space Force 2018-07-04T04:00:00Z Each day of his presidency seems to arrive de novo, disconnected historically from the day before. Did an Ancient Greek Anticipate Trump? 2018-06-22T04:00:00Z And why is the de novo pathway most active in organs involved in detoxification of the body in mammals? Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z Studying de novo genes turns out to be part genetics, part thought experiment. How evolution builds genes from scratch 2019-10-15T04:00:00Z One of the teams, led by Eichler, reported in October that they found ‘de novo’ mutations linked to autism in noncoding DNA. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z If not, are the respondents entitled to a trial de novo with the protection of the rules of evidence? The Judge Will Hear Your 223,000 Excuses Now 2018-03-16T04:00:00Z One analysis of families in Iceland showed that with each passing year, a man transmits an average of two more spontaneous, or de novo, mutations to his child. The link between autism and older parents is clear, but the why is not 2017-12-15T05:00:00Z Given the enrichment of enzymes of the de novo pathway in the kidney and liver, this particular strategy also raises the intriguing possibility of tissue-specific NAD+ manipulation. Increased synthesis of a coenzyme linked to longevity can combat disease 2018-10-23T04:00:00Z Researchers studying the rice strain Oryza sativa japonica found 175 of its genes were created de novo.Credit: How evolution builds genes from scratch 2019-10-15T04:00:00Z The study from the other team is in press, but found neither inherited nor de novo variants linked to autism in the regions. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z A molecular network for de novo generation of the apical surface and lumen. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos 2017-11-28T05:00:00Z A mathematical model of autism inheritance indicates that de novo mutations account for no more than 20 percent of the increased risk of autism among children of older fathers. The link between autism and older parents is clear, but the why is not 2017-12-15T05:00:00Z The contribution of de novo coding mutations to autism spectrum disorder. Kctd13 deletion reduces synaptic transmission via increased RhoA 2017-10-31T04:00:00Z Although de novo genes remain enigmatic, their existence makes one thing clear: evolution can readily make something from nothing. How evolution builds genes from scratch 2019-10-15T04:00:00Z They did not identify any noninherited, or de novo, mutations linked to autism. Some Mutations Tied to Autism May Be Passed Down from Fathers 2018-04-19T04:00:00Z Men accumulate de novo mutations four times faster than women, the researchers found. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z Henderson wrote in his ruling that it is “not the responsibility, nor within the authority of, the Hearing Officer to conduct a de novo review of the case and second guess his decision.” Dallas Cowboys’ Ezekiel Elliott has six-game suspension upheld but is to play Sunday 2017-09-05T04:00:00Z Moreover, some genetic conditions are the result of new, spontaneous changes in DNA, called “de novo” mutations. Perspective \| Five myths about gene editing 2017-08-24T04:00:00Z “One of the beauties of working with de novo genes,” says Casola, “is that it shows how dynamic genomes are.” How evolution builds genes from scratch 2019-10-15T04:00:00Z To decipher ‘de novo’ signatures, we implemented and applied the method described previously52 to the mutational catalogue of each subgroup. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z Maternal de novo mutations are especially concentrated in hotspots that comprise about 10 percent of the genome. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z Wigler’s team looked at simplex families and found rare de novo mutations in 27 genes. Using Big Data to Hack Autism 2017-07-06T04:00:00Z To obtain final genomes for analysis, we pooled data from multiple replicates of a sample, de novo assembled, and scaffolded against KX197192.1. Zika virus evolution and spread in the Americas : Nature : Nature Research 2017-05-23T04:00:00Z If nothing shows up, then it’s possible that the gene arose de novo. How evolution builds genes from scratch 2019-10-15T04:00:00Z On the basis of the label positions on single DNA molecules, de novo assembly was performed by a pairwise comparison of all single molecules and graph building62. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z “The de novo mutation rate in this part of the genome is almost twice what it is in the rest of the genome because of this big contribution from mothers,” Stefánsson says. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z Deploying statistical wizardry to combine the data on de novo and inherited mutations, along with CNV data from the Autism Genome Project, researchers pinpointed 65 genes and six CNVs as being key to autism. Using Big Data to Hack Autism 2017-07-06T04:00:00Z However, mCRPC showed overwhelming de novo resistance to immune checkpoint blockade3, 4, 5, motivating a search for targeted therapies that overcome this resistance. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z Many de novo genes remain uncharacterized, so the potential importance of the process to health and disease is unclear. How evolution builds genes from scratch 2019-10-15T04:00:00Z In the final section, we consider the prospect of truly de novo catalyst design affecting the field of synthetic organic chemistry via the paradigm of transition-state recognition using π interactions as a design element. Exploiting non-covalent π interactions for catalyst design : Nature : Nature Research 2017-03-28T04:00:00Z Stefánsson and his team are analyzing de novo mutations shared by siblings. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z In the second study, researchers screened for both inherited and de novo mutations and implicated 33 genes. Using Big Data to Hack Autism 2017-07-06T04:00:00Z The final de novo assembly used only single molecules with a minimum length of 150 kb and eight labels per molecule. The genome of Chenopodium quinoa : Nature : Nature Research 2017-02-07T05:00:00Z Counting de novo genes in the human genome comes with the same trail of caveats. How evolution builds genes from scratch 2019-10-15T04:00:00Z Given the seemingly sophisticated knowledge surrounding the physical underpinnings of each interaction discussed, one might inquire as to why genuine de novo design of catalysts for novel synthetic transformations is not commonplace. Exploiting non-covalent π interactions for catalyst design : Nature : Nature Research 2017-03-28T04:00:00Z The results may help researchers determine the likelihood that the sibling of a child with a condition caused by de novo mutations will also carry the mutation. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z Their calculations indicated that common variants account for 49 percent of the risk for autism in the general population; rare variants, equal parts de novo and inherited, explain 6 percent. Using Big Data to Hack Autism 2017-07-06T04:00:00Z Here we report the sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes. The seahorse genome and the evolution of its specialized morphology : Nature : Nature Research 2016-12-13T05:00:00Z But where de novo genes have been identified, researchers are beginning to explore their roles in health and disease. How evolution builds genes from scratch 2019-10-15T04:00:00Z EPA and the National Highway Traffic Safety Administration took the first step in this review—which they deemed a “de novo” rule-making—in July by publishing a draft technical assessment report for public review. The EPA’s Auto Outsourcing Act 2016-12-03T05:00:00Z “My guess is, most of the age association is not explained by de novo mutations.” Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z In April 2007, Wigler and his then colleague, Jonathan Sebat, reported that ‘de novo’ mutations—those that arise spontaneously instead of being inherited—occur more often in people with autism than in typical people. Using Big Data to Hack Autism 2017-07-06T04:00:00Z The cellular stress not only degrades the cell but also induces de novo aggregation85. The activities of amyloids from a structural perspective : Nature : Nature Research 2016-11-08T05:00:00Z To trace which of an organism’s genes were made de novo, researchers need comprehensive sequences for the organism and its close relatives. How evolution builds genes from scratch 2019-10-15T04:00:00Z Flowchart of the data generation, processing and analysing for the de novo assembly and haplotype phasing of the AK1 diploid genome. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z They found that mothers gain an average of 0.37 de novo mutations each year; fathers, by contrast, gain an average of 1.51 de novo mutations. Older Parents May Both Pass Down More New Mutations 2017-09-20T04:00:00Z An appeal may be taken from the circuit court to the Arkansas Supreme Court, which shall likewise be tried de novo. Arkansas colleges live with legacy of 1942 vote 2016-03-07T05:00:00Z The de novo assembly protocol was adapted from ref. The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea : Nature : Nature Publishing Group 2016-01-26T05:00:00Z The rice study got around this by explicitly identifying the pieces of non-coding DNA that became de novo genes. How evolution builds genes from scratch 2019-10-15T04:00:00Z This highly variable, complex region contained many SVs, making it difficult to phase against the reference genome, but allowed full resolution through the de novo approach. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z A de novo approach to analysis would be preferable, but this would currently result in insertion and deletion errors due to poor resolution of homopolymeric tracts on the MinION. Real-time, portable genome sequencing for Ebola surveillance : Nature : Nature Publishing Group 2016-02-02T05:00:00Z Unfortunately, deciphering the function of de novo genes is far more difficult than identifying them. A Surprise Source of Life's Code 2015-08-31T04:00:00Z Because a de novo assembly still generates many spurious transcripts, we used the transcript expression value to remove low quality contigs. The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea : Nature : Nature Publishing Group 2016-01-26T05:00:00Z For Zhang, research that links de novo genes to the human brain is tantalizing. How evolution builds genes from scratch 2019-10-15T04:00:00Z The optical maps were assembled de novo into genome maps. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z We compared the de novo assembled RNA-seq output to the genome to evaluate the completeness of the genome assembly. The octopus genome and the evolution of cephalopod neural and morphological novelties : Nature : Nature Publishing Group 2015-08-11T04:00:00Z Scientists also want to understand how de novo genes get incorporated into the complex network of reactions that drive the cell, a particularly puzzling problem. A Surprise Source of Life's Code 2015-08-31T04:00:00Z The Commissioners review the record and decide the case de novo, in other words with no deference to any of the ALJ’s rulings. The Real Problem With SEC Administrative Proceedings, and How To Fix It 2015-07-20T04:00:00Z One option for finding candidate de novo genes is to use an algorithm to search for similar genes in related species. How evolution builds genes from scratch 2019-10-15T04:00:00Z This highly variable, complex region contained many SVs, making it difficult to phase against the reference genome, but allowed full resolution through the de novo approach. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z It was hardly a theory I developed de novo, but rather is one many researchers had voiced—thought not yet proven. Why Men Are More Narcissistic Than Women 2015-03-05T05:00:00Z Evidence suggests that a portion of de novo genes quickly become essential. A Surprise Source of Life's Code 2015-08-31T04:00:00Z Circuit held that it would have concluded that the ads were deceptive even had it chosen to apply a de novo standard of review to the FTC’s findings. The D.C. Circuit's POM Wonderful Decision: Not So Wonderful For FTC's Randomized Clinical Trial Push 2015-02-04T05:00:00Z In the past five years, researchers have found numerous signs of these newly minted ‘de novo’ genes in every lineage they have surveyed. How evolution builds genes from scratch 2019-10-15T04:00:00Z Flowchart of the data generation, processing and analysing for the de novo assembly and haplotype phasing of the AK1 diploid genome. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z Court of Appeals for the Federal Circuit subjected a lower court’s ruling to a top-to-bottom de novo review. Supreme Court Hands Trial Courts More Power In Teva Patent Case 2015-01-20T05:00:00Z As a result, the number of de novo genes might explode. A Surprise Source of Life's Code 2015-08-31T04:00:00Z To compare mouse and human regulatory networks, we applied the de novo motif discovery approach that we developed previously28 and obtained a list of high-confidence sequence motifs using the ChIP-seq data sets. Principles of regulatory information conservation between mouse and human : Nature : Nature Publishing Group 2014-11-18T05:00:00Z Gene duplication is a “very conservative mechanism” she says, producing well-adapted proteins cut from the same cloth as their ancestors; de novo genes, by contrast, are likely to produce markedly different molecules. How evolution builds genes from scratch 2019-10-15T04:00:00Z We performed phasing against the de novo assembly. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z The mutations they discovered in the autistic children were dubbed de novo, after the Latin term for “afresh.” Autism Could Be Caused by Genetic Mutations in Over 100 Genes, According to New Research “The existence of de novo genes was supposed to be a rare thing,” said Mar Albà, an evolutionary biologist at the Hospital del Mar Research Institute in Barcelona, who presented the research. A Surprise Source of Life's Code 2015-08-31T04:00:00Z I contemplated using my machine, together with well-known biotechnical methods, to create, de novo, the H.I.V. genome — an actual molecule identical to that found in H.I.V. viruses living in the wild. Resurrecting Smallpox? Easier Than You Think 2014-10-15T04:00:00Z Long’s team wanted to know how many genes had emerged de novo in the strain Oryza sativa japonica, and what proteins those genes might be making. How evolution builds genes from scratch 2019-10-15T04:00:00Z One can’t conduct de novo review of a nullity, the oil company maintained. Chevron Defends Its RICO Victory in the Epic Ecuadorian Oil Pollution Case 2014-10-03T04:00:00Z Genes with loss-of-function de novo mutations are underlined and in italics. Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group 2014-07-21T04:00:00Z The results suggest that roughly 49 percent of the risk of developing autism can be attributed to common variants, versus 3 percent for rare, de novo variants. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z Prior to issuing its approval, the governmental agency subjected ReWalk through its de novo classification process, which is used for "first-of-its-kind medical devices." ReWalk bionic suit can now be sold in the US 2014-06-27T04:00:00Z The study gets at one of the field’s biggest preoccupations: how to tell whether a gene is truly de novo. How evolution builds genes from scratch 2019-10-15T04:00:00Z Ecuador’s system is different, however, and appellate courts there do engage in what’s known as de novo review of the facts. Chevron Defends Its RICO Victory in the Epic Ecuadorian Oil Pollution Case 2014-10-03T04:00:00Z The expected test statistics are calculated by averaging over 50,000 permuted de novo mutation sets. Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group 2014-07-21T04:00:00Z “The inter-relationship between common and rare variation and inherited and de novo variation is going to be the big thing for the next few years,” he says. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. [Research Articles] An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss 2014-04-30T18:55:14.141Z For example, an early study found 15 de novo genes in the whole primate order10; a later attempt found 60 in humans alone11. How evolution builds genes from scratch 2019-10-15T04:00:00Z Dr. Begun and his colleagues are now getting a look at these early stages in the birth of de novo genes. The Continuing Evolution of Genes 2014-04-28T21:20:18Z For cases in which there is a single affected proband and no family history, investigators should consider sequencing the unaffected parents of the probands, permitting efficient discovery of de novo mutations and compound heterozygous genotypes. Guidelines for investigating causality of sequence variants in human disease 2014-04-23T17:21:03.147Z Spontaneous risk The new study also calculated the contribution of de novo mutations—which are not included in estimates of inherited risk—at about 3 percent. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z Next we investigated whether de novo endoderm differentiation was preceded by a pluripotent state. Mouse liver repopulation with hepatocytes generated from human fibroblasts 2014-04-04T18:27:44.990Z Studies suggest that the cells’ repeated reproductions lead to the accumulation of random errors over time, called de novo mutations. Mental Illness Risk Higher for Children of Older Parents, Study Finds 2014-02-26T21:00:02Z Far from being a fluke, these studies suggest that de novo genes are abundant. The Continuing Evolution of Genes 2014-04-28T21:20:18Z We consider a single gene as the fundamental unit for monogenic disease gene testing, for all disease models; a disease caused by de novo mutations or a disease caused by inherited dominant or recessive variants. Guidelines for investigating causality of sequence variants in human disease 2014-04-23T17:21:03.147Z Much of autism research so far has focused on rare, de novo mutations, which appear spontaneously in individuals with autism. Common Mutations Account for Bulk of Autism Risk 2014-07-22T04:00:00Z However, the origin and spread of these de novo genes within populations remain obscure. [Report] Origin and Spread of de Novo Genes in Drosophila melanogaster Populations 2014-02-13T19:25:57.434Z To what extent does adaptation rely on de novo mutation, as opposed to preexisting variation? [Report] Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish 2013-12-12T19:26:55.319Z Dr. Schlötterer and his colleagues found the answer in their study: Along each lineage, many de novo genes are also lost. The Continuing Evolution of Genes 2014-04-28T21:20:18Z The acquisition of de novo mutations might enhance the cells' therapy resistance, enabling the tumour to relapse and the disease to progress. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z It descends in families, rarely arising de novo. Former TV reporter campaigns to bring Huntington’s disease out of the shadows 2013-07-29T22:24:55Z This functionally links decreased de novo SL synthesis to asthma and so identifies this metabolic pathway as a potential target for therapeutic interventions. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z Repeat sequences were identified by combining de novo approaches and sequence similarity at the nucleotide and protein levels. Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation 2013-04-03T17:22:05.187Z Dr. Begun and his colleagues renamed orphan genes “de novo genes,” from the Latin for new. The Continuing Evolution of Genes 2014-04-28T21:20:18Z The acquisition of de novo mutations might enhance the cells' therapy resistance, enabling the tumour to relapse and the disease to progress. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z Healy, it was pointed out in the judgment, did not request a de novo hearing at the appeal. Teams make the scrum a problem by bypassing rugby rulemakers' changes 2013-03-28T12:42:33Z The present study analyzes the effect of decreased de novo SL synthesis in the lung on airway reactivity after administration of myriocin, an inhibitor of SPT, and in SPT heterozygous knockout mice. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z We expect growth in de novo clinics to be funded internally. TEXT-S&P rates ATI Holdings 'B', outlook stable; new debt rated 2013-01-11T15:50:28Z Dr. Begun suspects that the true number of de novo genes in the flies is higher. The Continuing Evolution of Genes 2014-04-28T21:20:18Z Only a small number of de novo genetic variants were detected in serially transplanted tumours compared with primary patient samples. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z We see mosaics, balanced de novo translocations, inversions, marker chromosomes … the frequency of all of those is about 1 percent,” Ronald Wapner, MD, told me. The Battle of the Prenatal Tests 2012-12-05T23:15:04.403Z We show that, in both models, decreased de novo SL synthesis increases bronchial reactivity in the absence of inflammation. [Research Articles] Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity 2013-05-22T18:55:07.587Z She is missing material on her fourth chromosome, a de novo deletion, meaning it was just a random deletion, not something she inherited. The Trouble with My Daughter's DNA 2012-10-28T21:05:21Z Gene models were obtained by integrating results of de novo gene prediction and alignment-based methods based on homology and transcriptomic evidence. The oyster genome reveals stress adaptation and complexity of shell formation 2012-10-03T18:22:26.103Z When the dominant pretherapy clone remains dominant after relapse, the dominant clone often gains de novo mutations. Tumour heterogeneity and cancer cell plasticity 2013-09-18T17:21:13.347Z But unlike his and Laurie’s situation, their inversion was “de novo.” The Battle of the Prenatal Tests 2012-12-05T23:15:04.403Z Consequently, applying de novo motif discovery to the footprint compartments gleaned from multiple cell types should greatly expand our current knowledge of biologically active transcription factor binding motifs. An expansive human regulatory lexicon encoded in transcription factor footprints 2012-09-05T17:21:56.447Z Dr. Stefansson said that it made sense that de novo mutations would play a significant role in brain disorders. Father’s Age Is Linked to Risk of Autism and Schizophrenia 2012-08-22T17:18:06Z Although using pedigree information or combining it with population data provides further phasing power, no combination of these methods is able to resolve de novo mutations. Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells 2012-07-11T17:21:04.120Z We have developed a de novo reference genome sequence that will facilitate evolutionary and ecological studies in this key group of butterflies. Butterfly genome reveals promiscuous exchange of mimicry adaptations among species 2012-07-04T17:21:31.773Z They also managed to detect 39 of 44 de novo mutations in the fetus, but with false positives. Fetal Genome Deduced from Parental DNA 2012-06-07T22:15:00.207Z They found that the prenatal reconstruction was more than 98% accurate when compared to the actual postnatal sequence, although it missed five de novo mutations. Decoding an Unborn Baby's DNA: Should We Worry or Celebrate? 2012-06-06T23:36:28Z Furthermore, 39 of 44 de novo point mutations in the fetal genome were detected, albeit with limited specificity. [Research Articles] Noninvasive Whole-Genome Sequencing of a Human Fetus 2012-06-06T19:25:14.950Z For the initial child in the study, 44 de novo mutations were identified after birth -- none of which were anticipated to cause severe disease. Sequencing the Unborn 2012-06-06T19:00:00Z In an analysis of 51 de novo mutations, Dr. Eichler’s group found that glitches were four times more likely to originate in DNA from the male than from the female. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-05T19:52:27Z Further analysis, drawing on data from a larger sample, turned up two more genes disrupted by multiple de novo glitches, also named by Daly's group. Rare gene mutations increase autism risk, studies say 2012-04-05T00:26:03Z They identified 125 de novo mutations that would change the readout of genes among the children with autism and 87 among their unaffected siblings. Researchers Find Gene Mutations That May Be a Key to Autism 2012-04-04T18:00:00Z Although technical and analytical challenges remain, we anticipate that noninvasive analysis of inherited variation and de novo mutations in fetal genomes will facilitate prenatal diagnosis of both recessive and dominant Mendelian disorders. [Research Articles] Noninvasive Whole-Genome Sequencing of a Human Fetus 2012-06-06T19:25:14.950Z Further analysis, drawing on data from a larger sample, turned up two more genes disrupted by multiple de novo glitches, also named by Dr. Daly’s group. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-04T17:45:44Z All three studies also found evidence that the risk of de novo mutations increases with parental age. Scientists Link Rare Gene Mutations to Heightened Risk of Autism 2012-04-05T19:52:27Z It is an attempt to start de novo with certain concepts of society and government. The Political Doctrines of Sun Yat-sen: An Exposition of the San Min Chu I 2012-04-04T02:00:55.303Z Eichler's team also found that de novo mutations were four times as likely to lie on DNA strands inherited from the father, and that the number of mutations increases with paternal age. Researchers Find Gene Mutations That May Be a Key to Autism 2012-04-04T18:00:00Z It would not be more wonderful, de novo, than the discovery of the lightning-rod, or navigation by steam! Pencillings by the Way Written During Some Years of Residence and Travel in Europe 2012-03-19T02:00:26.650Z Is it, in other words, ever generated de novo? A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The productive powers of the land become exhausted in a few years, when the clearing is abandoned, a new site is chosen, and the same operations are carried on de novo. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 9 "Dagupan" to "David" 2012-02-11T03:03:39.807Z By this time too it was realized that the formation of cells de novo, postulated by Schleiden’s theory of “phytogenesis,” did not occur. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 8 "Cube" to "Daguerre, Louis" 2012-01-31T03:00:17.257Z "The time to generation of a virus by de novo engineering from raw sequence data is probably longer than the age-old method of virus passage in mammals/mammalian cells." Prominent Virologists Want U.S. Advisory Board to Take a Second Look at Controversial Flu Papers 2012-01-20T16:44:14Z This idea began to change in 2002, when the poliovirus was synthesized de novo. Preventing pandemics: The fight over flu 2012-01-18T18:20:33.007Z There are no sustained observations which prove that yellow-fever poison is ever created de novo. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Consequently, the agreement was held to be vitiated, and the legal proceedings had to be recommenced de novo. Legal Lore Curiosities of Law and Lawyers 2012-01-17T03:00:20.443Z It is, of course, impossible for any organism, however small, to create itself de novo. The Fijians A Study of the Decay of Custom 2011-12-30T03:00:25.917Z Well, let us get back to Ward and begin de novo. Why Lincoln Laughed 2011-12-29T03:00:17.037Z The nets are hauled in, the fish flung out on the river banks, and the same process begins de novo. Alone with the Hairy Ainu or, 3,800 miles on a pack saddle in Yezo and a cruise to the Kurile Islands. 2011-10-30T02:00:10.270Z Whereas many countries will adopt similar standards rather than developing them de novo, the variety of perspectives dictates that in respect for others we must accept a variety of regulatory solutions. Should Scientists Use Genetically Modified Insects to Fight Disease? 2011-10-24T15:15:00.253Z Another set of compounds are designed completely de novo, based on knowledge of the target site. Lunchtime science 2011-10-12T17:20:55.227Z At the close of the year Paine wrote the whole work de novo. The Life Of Thomas Paine, Vol. II. (of II) With A History of His Literary, Political and Religious Career in America France, and England 2011-10-12T02:00:47.957Z It is quite a mistake to suppose that he had to begin de novo, and to re-establish Paganism. Sermons 2011-09-26T02:00:27.830Z Secondly, the human mind does not at any time commence its philosophic speculations de novo. Determinism or Free-Will? 2011-09-10T02:00:27.557Z These he worked upon, de novo, during the long recess, and ‘rich and rare’ indeed was the collection; it was the poor messenger’s only comfort. Nicotiana Or The Smoker's and Snuff-Taker's Companion 2011-07-29T02:00:29.353Z However, none of them produced de novo DNA sequence, addressed the issue of delivering template DNA to the sensors, or scaled to large arrays. An integrated semiconductor device enabling non-optical genome sequencing 2011-07-20T17:20:42.953Z It is apparently the sole work which he ever wrote, created de novo and without the data having been found or brought to him from without. Concerning Lafcadio Hearn With a Bibliography by Laura Stedman 2011-07-20T02:00:12.413Z It's a lot easier to gain people's trust de novo than to try and regain after you've lost it. CIA's Fake Vaccination Drive Angers Public Health World 2011-07-13T20:39:05Z Improved assembly algorithms, increased read lengths, and de novo sequences of additional haplotypes will reveal the full catalogue of genes critical to inbreeding depression. Genome sequence and analysis of the tuber crop potato 2011-07-13T17:21:42.673Z “We frankly don't understand biology well enough to start designing genomes de novo.” Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z As is well known, a language is not created de novo, but by a slow process of development. North America 2011-05-05T02:00:20.027Z The need was for scientific standpoints to be investigated de novo; and the process had, as a matter of fact, already been begun on the Continent. Religion and Science From Galileo to Bergson 2011-04-07T02:00:16.760Z It would certainly be impossible if we had to begin de novo to construct the whole fabric of economic science. Encyclopaedia Britannica, 11th Edition, Volume 8, Slice 10 "Echinoderma" to "Edward" 2011-01-19T03:00:19.027Z Such “copy number variants” may occur de novo in apparently sporadic cases of schizophrenia or autism. Slipping the 'Cognitive Straitjacket' of Psychiatric Diagnosis 2011-01-04T16:17:14.270Z They will look at the case de novo, that is, anew, and won't need to show any deference to his legal conclusions. Why California's Prop 8 Against Gay Marriage Was Struck Down 2010-08-05T08:35:00Z We are not made so that we can invent everything de novo, or escape the effect on our minds of what has preceded us; the attempt can only lead to baldness or eccentricity. Encyclopaedia Britannica, 11th Edition, Volume 2, Slice 4 "Aram, Eugene" to "Arcueil" He at once set about organizing that department de novo. The History of Cuba, vol. 4 The question remained whether this product was generated de novo. History of Phosphorus It is difficult to believe that it was constructed de novo, or all at one time. The Towns of Roman Britain Absence of capital, of concentrated wealth, made it necessary to begin de novo. The Galaxy, April, 1877 Vol. XXIII.—April, 1877.—No. 4. The production of rocks de novo upon the earth's surface. The Coming of Evolution The Story of a Great Revolution in Science As the Lords had thrown out the Reform Bill, it was necessary to A Dead Lock. begin de novo. English Caricaturists and Graphic Humourists of the Nineteenth Century. How they Illustrated and Interpreted their Times. Organisms representing previous thoughts will be added to, in order to express the expansion of the thought, instead of a creation de novo in each instance. The Philosophy of Evolution Together With a Preliminary Essay on The Metaphysical Basis of Science As a primary consideration any condition which lowers the vitality or vigor of the calf must be accorded a prominent place among factors which, apart from contagion, contribute to start the disease de novo. Special Report on Diseases of Cattle They did not make offices absolutely de novo, but they did condense and combine old offices in a manner that practically made a new thing of them. A Short History of the Book of Common Prayer Doubtless, therefore, without either production of microcytes or production de novo, the number of red corpuscles in capillary blood may undergo considerable variations. Histology of the Blood Normal and Pathological If they had concurred in reversing the judgment which disallowed the challenge to the array, the only effect would have been, to order a venire de novo, or a new trial. Blackwood's Edinburgh Magazine, Volume 56, Number 349, November, 1844 In the illustration above we have assumed that a monopoly was starting de novo. The Evolution of Modern Capitalism A Study of Machine Production This progressive development of nature and humanity has not been a series of creations de novo, without any relation, in matter or form, to that which preceded. Christianity and Greek Philosophy or, the relation between spontaneous and reflective thought in Greece and the positive teaching of Christ and His Apostles It is the failure to observe this plain canon of style that has made shipwreck of many an attempt to construct liturgies de novo. A Short History of the Book of Common Prayer The new moon is considered pre-eminently auspicious for commencements,--for all kinds of building up, and beginning de novo. Moon Lore A new language arising with any people de novo can nowhere be found. The New Avatar and The Destiny of the Soul The Findings of Natural Science Reduced to Practical Studies in Psychology If changed, she must be registered de novo, and the old certificate cancelled. The Sailor's Word-Book An Alphabetical Digest of Nautical Terms, including Some More Especially Military and Scientific, but Useful to Seamen; as well as Archaisms of Early Voyagers, etc. Although he had been told that it would be so, he did not realise until that moment that the trial would have to commence de novo. The Day of Judgment I have to begin de novo, and perhaps can't take into account all the forces which have been growing up through the ages. "The Pomp of Yesterday" He did not see me, and I was not anxious to begin de novo the disagreeable discussion of the morning. Blackwood's Edinburgh Magazine - Volume 55, No. 343, May 1844 According to them, the contagia of epidemic disease are formed de novo in a putrescent atmosphere. Fragments of science, V. 1-2 Childhood impressions are ever the most lasting, and so long as one-half of the Orient remained untouched by progressive influences Oriental progress had to be begun again de novo with every succeeding generation. The New World of Islam Speaking generally, we may say that no word is ever created de novo. The Romance of Words (4th ed.) I have to be always beginning de novo. "The Pomp of Yesterday" Said or not said, let us presume it unsaid, and let me state the true answer as if de novo, even if by accident somewhere the darkness shelters this same answer as uttered long ago. The Posthumous Works of Thomas De Quincey, Vol. 1 In the words of Dr. Bastian: 'We can only infer that whilst the boiled saline solution is quite incapable of engendering bacteria, such organisms are able to arise de novo in the boiled organic infusion.' Fragments of science, V. 1-2 After it had been written as usual, twice over, we kept it by us, bringing it out from time to time, and going through it "de novo," reading, weighing and criticizing every sentence. Little Journeys to the Homes of the Great - Volume 13 Little Journeys to the Homes of Great Lovers But by the time that he has just disenthralled himself, he is removed, and another appointed in his place, and the work has to commence de novo. Diary in America, Series Two Only Greek science, and the scientific spirit, were almost completely lost, and a beginning de novo had to be made when the West shook off its fetters. The Legacy of Greece Essays By: Gilbert Murray, W. R. Inge, J. Burnet, Sir T. L. Heath, D'arcy W. Thompson, Charles Singer, R. W. Livingston, A. Toynbee, A. E. Zimmern, Percy Gardner, Sir Reginald Blomfield Freedom and initiative never begin entirely de novo. Christianity and Ethics A Handbook of Christian Ethics The inference just referred to is completely disposed of by the simple question: 'Why, when your sterilised organic infusion is exposed to optically puree air, should this generation of life de novo utterly cease? Fragments of science, V. 1-2 The mosquito, of course, criminal as she is, does not hatch the parasites de novo in her own body, but simply sucks them up in a meal of blood from some previous victim. Preventable Diseases The discordant tones of the violin, as the new string was tortured into tune, once more opened the safety-valve, and the ball began de novo. Hudson Bay He objects on principle to the origin of organs de novo. Form and Function A Contribution to the History of Animal Morphology Anthropology needs trained devotees with philosophic methods and keen observation to study every tribe and nation of the globe almost de novo; and from, materials thus collected a science may be established. On Limitations To The Use Of Some Anthropologic Data Life cannot supply energy de novo, cannot create it out of nothing, but it can and must draw upon the store of energy in which the earth floats as in a sea. The Breath of Life They sold out the farm they put in shape, after two years' work, for just ten times what it had cost, and they are now starting another one de novo. The Life and Letters of Walter H. Page, Volume I It seems to me, therefore, that in seeking to estimate the evidence of design in Nature, we must as it were start de novo, without reference to anterior beliefs upon the subject. Thoughts on Religion So that doubting concerning the Eternity of the World, and its Existence de novo, did him no harm at all. The Improvement of Human Reason Exhibited in the Life of Hai Ebn Yokdhan Mohamad says that he will not return to Casembe again, but will begin to trade with some other chief: it is rather hard for a man at his age to begin de novo. The Last Journals of David Livingstone, in Central Africa, from 1865 to His Death, Volume I (of 2), 1866-1868 The feeling was so strong that many were prepared to abandon the whole scheme and start de novo rather than continue an undertaking in which it looked as though they were being fooled. The Transvaal from Within A Private Record of Public Affairs The world was to be turned topsy-turvy; and poetry, by the good will of our Adam-wits, was to share its fate and begin de novo. Lectures on the English Poets Delivered at the Surrey Institution Furthermore we decree that Doctors, lecturing ordinarily or extraordinarily, must come to the sections assigned de novo, according to the regulations below. Readings in the History of Education Mediaeval Universities Mr. Hogarth, indeed, concludes that 'it is hopeless now to sift his work; those who would treat the site of Alexandria scientifically must ignore him and start de novo'. Ancient Town-Planning Do they spring up de novo from the highest point on the area of not-life, which they touch? Scientific American Supplement, No. 470, January 3, 1885 The ceremony was prepared de novo for the occasion and the pledges were mutual. Evolution Of The Japanese, Social And Psychic He may take his chances of success in the Land Office, and if at any time he becomes apprehensive of an adverse decision he may begin de novo in the courts. A Compilation of the Messages and Papers of the Presidents Volume 9, part 1: Benjamin Harrison Out of this vast sea of mud Nature has had to evolve another creation, beginning de novo, with her lowest forms. The Collected Works of Ambrose Bierce, Volume 1 The impressions, ‘laid up in the brain, will be reversed back to the retiform coat and crystalline humour,’ hence ‘a lively seeing, as if, de novo, the object had been placed before the eye’. Cock Lane and Common-Sense A trenchant and resolute advocate of the origin of living forms de novo has published what he considers a crucial illustration in support of his case. Scientific American Supplement, No. 470, January 3, 1885 In this case, the proceedings on the trial will be commenced de novo, if the reference has been made on the ground of any informality or illegality in the previous trial. The Principles of Masonic Law A Treatise on the Constitutional Laws, Usages and Landmarks of Freemasonry Nothing can be done de novo; a fresh beginning cannot be had. George Eliot; a Critical Study of Her Life, Writings & Philosophy Now here also, as in His teaching about God, Christ did not need to begin de novo. The Teaching of Jesus The "vocabulary of Chippewa," so far as it is Chippewa at all, has the French or a mixed orthography, which it is not probable that an Englishman or an American would, de novo, employ. Personal Memoirs of a Residence of Thirty Years with the Indian Tribes on the American Frontiers It is taken up de novo by some inventor, stimulated by the needs of his time, and falling again upon the track, he recovers the old footmarks, follows them up, and completes the work. Industrial Biography, Iron Workers and Tool Makers If Mr. Forrest in former days established his fame as an explorer, his late expedition only proves that he must commence de novo. Explorations in Australia, Illustrated, The necessary chemical re-agents to reproduce life, as well as the necessary processes of producing it de novo have not yet been ascertained, nor is it likely they ever will be. Life: Its True Genesis Christ, we must remember, did not, in His teaching, begin de novo. The Teaching of Jesus Now in the contents of the pamphlet I read: 'Small-pox—never produced at present de novo.'… Memoir and Letters of Francis W. Newman After it had been written as usual twice over, we kept it by us, bringing it out from time to time, and going through it de novo, reading, weighing, and criticizing every sentence. Autobiography It was necessary to commence de novo, but this could no longer be done with the first course, which was removed, and Aristabulus set-to, with zeal, forthwith, on the game. Home as Found Professor Bastian thinks he has conclusive evidence that what he calls "new-born specks of living matter" are produced de novo, that is, independently of any conceivable germ or germinal principle of life implanted in nature. Life: Its True Genesis In any new life of Swift the case must be stated de novo. Note Book of an English Opium-Eater One dare affirm that man cannot create life de novo any more than he can create matter. Time and Change But-"qui se dispute, s'adore"-when we again met all would be forgotten, and the old tale be told over de novo. Personal Narrative of a Pilgrimage to Al-Madinah & Meccah — Volume 1 On the other hand, malignant endocarditis may apparently develop de novo. Disturbances of the Heart His flask experiments, therefore, prove nothing; and all this talk about de novo production is the sheerest scientific delusion. Life: Its True Genesis Talking of "natural selection;" if I had to commence de novo, I would have used "natural preservation." Life and Letters of Charles Darwin — Volume 2 Through his knowledge and his science man performs wonders every day; he can reduce mountains to powder and seas to dry land, but he cannot create or start de novo the least throb of life. Time and Change There is a truth, however, in De Maistre's doctrine that constitutions are generated, or developed, not created de novo, or made all at once. The American Republic : constitution, tendencies and destiny Towards 1870 it was first demonstrated that cell-nuclei do not arise de novo, but are invariably the result of division of pre-existing nuclei. Darwin and Modern Science Both are essentially endowed with the same potentiality of originating life independently of vital units, or de novo, as they more persistently phrase it. Life: Its True Genesis Each seems to think that the whole subject should begin de novo because he has asked for information. The New Revelation
随便看	constructively constructiveness constructivism constructivist constructor construe construe with consubstantial consubstantiate consubstantiation consuetude consuetudinary consul consular consulate consulship consult consultancy consultant consultation consultative consultatory consulting company consulting firm consulting service