英语词汇“cytotoxic”造句子简单的方法、技巧、例句及翻译-英语例句辞典

Their lungs should have been home to a diverse bunch of CD4+ T cell types but, in this group, more than 65 per cent of their cells were cytotoxic CD4+ tissue-resident memory T cells. Specialized T cells may trigger severe asthma attacks in older men 2023-10-23T04:00:00Z

There are three types of T cells: cytotoxic, helper, and suppressor T cells. Biology for AP Courses 2022-06-09T00:00:00Z

This separation prevents the mother’s cytotoxic T cells from reaching and subsequently destroying the fetus, which bears “non-self” antigens. Anatomy and Physiology 2013-06-19T00:00:00Z

"Therapeutic cancer vaccines would be given to cancer patients with the hope that those vaccine-induced cytotoxic T cells would clear tumor cells." mRNA vaccines changed the course of the pandemic. Now, they could cure all kinds of other diseases 2021-11-22T05:00:00Z

Half of the immune system—such as cytotoxic or “killer” T cells and antibody-producing B cells—is designed to fight. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z

There they act as homing beacons for specialized assassins called cytotoxic, or killer, T-cells. In Autoimmune Disease, Organs May Lure the Immune System into an Attack 2021-09-14T04:00:00Z

The humoral immune response produces cytotoxic T cells that induce apoptosis in pathogen-infected cells. Biology for AP Courses 2022-06-09T00:00:00Z

When a donor organ expresses MHC molecules that are different from the recipient, the latter will often mount a cytotoxic T cell response to the organ and reject it. Anatomy and Physiology 2013-06-19T00:00:00Z

The immune system, presented with the peptide, learns to recognize the virus and releases cytotoxic T cells and B cells. Merck will help make Johnson & Johnson coronavirus vaccine as rivals team up to help Biden accelerate shots 2021-03-02T05:00:00Z

There are also “killer,” or cytotoxic, T cells, which are capable of destroying infected cells. Oxford coronavirus vaccine safe and promising, according to early human trial results published in the Lancet 2020-07-20T04:00:00Z

T-cells are cytotoxic – powerful serial killers that can recognise peptide fragments of virus displayed on the infected cell surface. Here's how your body gains immunity to coronavirus | Zania Stamataki 2020-04-10T04:00:00Z

The population expressed various cytotoxic genes, and was enriched in the hippocampus — a brain region crucial for human memory. An immune-cell signature marks the brain in Alzheimer’s disease 2020-01-07T05:00:00Z

There are several functional types of T lymphocytes, the major ones being helper, regulatory, and cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z

The authors investigated how the level of tumour-infiltrating cytotoxic CD8 T cells varied. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z

Immunotherapy uses immune cells called T cells to target cancer in the clinic; however, these tumour-killing cytotoxic CD8 T cells are short-lived. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z

The cytotoxic CD4 T-cells are likely the offspring of a sole “ancestor cell.” Supercentenarians live longer than others because of this, study suggests 2019-11-15T05:00:00Z

Bacteria and fungi are especially susceptible to damage by complement proteins, whereas viruses are taken care of by interferons and cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z

One set consisted of cytotoxic CD8 T cells that express high levels of cancer-killing molecules but that also express ‘immune-checkpoint’ molecules. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z

Therefore, if T cells are REGNASE-1 deficient, they are better equipped to sustain high numbers of cytotoxic CD8 T cells in tumours and produce a prolonged antitumour response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z

Our pharmaceutical products fall into this latter category because its products are intended to treat cancer and contain cytotoxic agents. HOVERINK BIOTECHNOLOGIES APPOINTS VSTOCK TRANSFER, LLC AS ITS TRANSFER AGENT AND REGISTRAR 2018-07-11T04:00:00Z

This is to the advantage of the virus, because without class I expression, cytotoxic T cells have no activity. Anatomy and Physiology 2013-06-19T00:00:00Z

The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Runx3 programs CD8⁺ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z

The ideal population of T cells for use in ACT would infiltrate tumours and accumulate in substantial numbers while retaining cytotoxic function and the capacity for self-renewal2. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z

DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair 2017-11-07T05:00:00Z

These MHC molecules may then stimulate a cytotoxic T cell immune response, eventually destroying the cell and the pathogen within. Anatomy and Physiology 2013-06-19T00:00:00Z

The inflammation-induced IgA+ cells promote the progression to hepatocellular carcinoma by suppressing liver cytotoxic CD8+ T cells that prevent the emergence of this aggressive tumour. Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Runx3 programs CD8⁺ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z

Yet the differentiation of T cells into cytotoxic CD8 T cells impairs successful retention of the potential to form long-lived memory cells. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z

The other 40 percent, which he does not yet provide in house but wants to, is cytotoxic, known as chemotherapy. Doctor gives back and helps town’s cancer patients 2017-06-05T04:00:00Z

These sensitized T cells, of the Th1 class, will also activate cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z

Here, we leverage our ability to recover precise CD4 neoantigens to discover and augment the cytotoxic potential of the neoantigen-specific CD4+ T cells. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens : Nature : Nature Research 2017-03-21T04:00:00Z

Compared with men, more NK cells from women exhibited a greater destructive—or cytotoxic—response to leukemia cells, as indicated by significantly higher expression of a protein marker of NK cell activity. A New Clue to Why Women Outlive Men 2016-06-13T04:00:00Z

Delivering chemo directly into the abdomen "may improve efficacy by increasing concentration of the cytotoxic agent directly against the tumor in the abdominal cavity," Chuang said. Two-Pronged Chemo Helps Some With Advanced Ovarian Cancer 2016-06-04T04:00:00Z

Initially, these targeted therapeutic agents followed the same clinical development pathway as cytotoxic chemotherapy, that is, based on tumour location and histopathology, driven by the notion that molecular aberrations were tumour specific. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z

If an ectopic pregnancy is detected early, the embryo’s development can be arrested by the administration of the cytotoxic drug methotrexate, which inhibits the metabolism of folic acid. Anatomy and Physiology 2013-06-19T00:00:00Z

Some of these so-called “élite controllers” possess cytotoxic, or killer, T cells that attack virus-producing cells. Can AIDS Be Cured? | The New Yorker 2014-12-15T05:00:00Z

A promising new approach for advanced cancer selectively delivers cytotoxic agents to tumor cells without the collateral damage to normal, healthy tissue. Cleveland Clinic Announces Top 10 Medical Innovations For 2015 2014-10-29T04:00:00Z

"I find this drug interesting because it represents an attempt to step beyond the usual cytotoxic agents. But on its own, it's not a remarkable breakthrough," Edelman said. Experimental Drug May Extend Lung Cancer Survival, Study Suggests 2014-05-31T04:00:00Z

This assumption was substantially correct for approaches such as cytotoxic chemotherapy that target generic disease mechanisms, and it enabled considerable progress to be made in treating cancer. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z

It shares this mechanism with the cytotoxic T cells of the adaptive immune response. Anatomy and Physiology 2013-06-19T00:00:00Z

TcA forms a large bell-shaped pentameric structure and enters the membrane like a syringe, forming a translocation channel through which the cytotoxic domain is probably transported into the cytoplasm. Mechanism of Tc toxin action revealed in molecular detail 2014-04-04T18:24:45.845Z

In cell culture, for example, an immune cell called a cytotoxic T cell will kill a cancer cell in a matter of minutes. Medical imaging: Removing the blindfold 2013-12-18T18:50:58.412Z

DNA integrity is frequently compromised as a result of exposure to cytotoxic agents, as well as the normal wear and tear of cellular processes like transcription and replication. [Perspective] Finding the Right Partner in a 3D Genome 2013-12-12T19:26:06.028Z

When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired. [Report] Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse 2013-12-05T18:57:29.425Z

Thus, NK and cytotoxic T cells have complementary activities against virally infected cells. Anatomy and Physiology 2013-06-19T00:00:00Z

To investigate this, blood samples were collected from the mice and tested for the presence of anti-tumour immune cells, known as cytotoxic T lymphocytes. Cancer research: Of mice and men 2013-11-21T16:03:54Z

Experimentally, cytotoxic chemotherapy or radiation treatment increased factors that mediate macrophage trafficking and intratumoral macrophages. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

Consistent with this idea, in vitro, microsatellite-instability colorectal cancer cell lines are more sensitive than chromosomally unstable cell lines to a range of different targeted and cytotoxic agents. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z

In vitro T cell proliferative responses, natural killer cell cytotoxic activity, immune synapsis formation, and suppressive function of T regulatory cells were normalized. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z

The cytotoxic T cell response, though, is key, as it eventually overwhelms the virus and kills infected cells before the virus can complete its replicative cycle. Anatomy and Physiology 2013-06-19T00:00:00Z

In patients with diverse tumor types treated on a phase 1 trial, CDC developed within 4 to 8 weeks in most patients; normal cells were resistant to the cytotoxic effects. [Research Articles] Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans 2013-05-15T18:55:05.140Z

In breast cancer, assessment of pro- and antitumour immunity revealed that high macrophage content relative to cytotoxic T-cell content was correlated with a worse outcome than those with a low content. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

Cells grown in dish cultures are nearly always less resistant to cytotoxic agents than those grown in 3D matrices; the main difference, Zaman says, is the forces they experience. Mechanics: The forces of cancer 2012-11-23T15:20:56.230Z

“Youngsters’ brains are more susceptible to the cytotoxic shock of concussions and as a group they tend to recover more slowly. NFL needs to get seriousness of concussions through its head 2012-11-14T02:31:58Z

Clonal expansion and the ability of cytotoxic T cells to kill more than one target cell make these cells especially effective against viruses. Anatomy and Physiology 2013-06-19T00:00:00Z

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. Subgroup-specific structural variation across 1,000 medulloblastoma genomes 2012-08-01T17:52:08.330Z

This result suggests a positive contribution of cytotoxic T cells to the therapeutic effect. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z

Normally, cytotoxic T cells destroy only infected cells; T cells that react to molecules native to the body are eliminated before they mature, thus endowing the immune system with tolerance to 'self'. Pathology: Cause and effect 2012-05-22T15:21:12.780Z

They compared the number of cytotoxic T cells—which help battle a virus by killing body cells that harbor it—in normal mice and animals missing IL-33. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z

All eight patients received cytarabine and anthracycline for induction therapy, and additional cytotoxic chemotherapy for consolidation; treatment histories are summarized in and described in . Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z

Survivors are often left with significant neurological, intellectual and physical disabilities secondary to the effects of these nonspecific cytotoxic therapies on the developing brain. Subgroup-specific structural variation across 1,000 medulloblastoma genomes 2012-08-01T17:52:08.330Z

Pinschewer and colleagues also tested whether the cells that emit IL-33 are in the right place in the body to influence cytotoxic T cells. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z

The genetically altered mice carried 90% fewer cytotoxic T cells targeted against the virus than did normal animals, a deficiency that translated into a weaker immune counterattack. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z

Besides expanding the ranks of cytotoxic T cells, IL-33 seems to prime them for combat. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z

单词	cytotoxic
例句	cytotoxic Their lungs should have been home to a diverse bunch of CD4+ T cell types but, in this group, more than 65 per cent of their cells were cytotoxic CD4+ tissue-resident memory T cells. Specialized T cells may trigger severe asthma attacks in older men 2023-10-23T04:00:00Z There are three types of T cells: cytotoxic, helper, and suppressor T cells. Biology for AP Courses 2022-06-09T00:00:00Z This separation prevents the mother’s cytotoxic T cells from reaching and subsequently destroying the fetus, which bears “non-self” antigens. Anatomy and Physiology 2013-06-19T00:00:00Z "Therapeutic cancer vaccines would be given to cancer patients with the hope that those vaccine-induced cytotoxic T cells would clear tumor cells." mRNA vaccines changed the course of the pandemic. Now, they could cure all kinds of other diseases 2021-11-22T05:00:00Z Half of the immune system—such as cytotoxic or “killer” T cells and antibody-producing B cells—is designed to fight. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z There they act as homing beacons for specialized assassins called cytotoxic, or killer, T-cells. In Autoimmune Disease, Organs May Lure the Immune System into an Attack 2021-09-14T04:00:00Z The humoral immune response produces cytotoxic T cells that induce apoptosis in pathogen-infected cells. Biology for AP Courses 2022-06-09T00:00:00Z When a donor organ expresses MHC molecules that are different from the recipient, the latter will often mount a cytotoxic T cell response to the organ and reject it. Anatomy and Physiology 2013-06-19T00:00:00Z The immune system, presented with the peptide, learns to recognize the virus and releases cytotoxic T cells and B cells. Merck will help make Johnson & Johnson coronavirus vaccine as rivals team up to help Biden accelerate shots 2021-03-02T05:00:00Z There are also “killer,” or cytotoxic, T cells, which are capable of destroying infected cells. Oxford coronavirus vaccine safe and promising, according to early human trial results published in the Lancet 2020-07-20T04:00:00Z T-cells are cytotoxic – powerful serial killers that can recognise peptide fragments of virus displayed on the infected cell surface. Here's how your body gains immunity to coronavirus \| Zania Stamataki 2020-04-10T04:00:00Z The population expressed various cytotoxic genes, and was enriched in the hippocampus — a brain region crucial for human memory. An immune-cell signature marks the brain in Alzheimer’s disease 2020-01-07T05:00:00Z There are several functional types of T lymphocytes, the major ones being helper, regulatory, and cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z The immune system, presented with the peptide, learns to recognize the virus and releases cytotoxic T cells and B cells. Merck will help make Johnson & Johnson coronavirus vaccine as rivals team up to help Biden accelerate shots 2021-03-02T05:00:00Z The authors investigated how the level of tumour-infiltrating cytotoxic CD8 T cells varied. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z Immunotherapy uses immune cells called T cells to target cancer in the clinic; however, these tumour-killing cytotoxic CD8 T cells are short-lived. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z The cytotoxic CD4 T-cells are likely the offspring of a sole “ancestor cell.” Supercentenarians live longer than others because of this, study suggests 2019-11-15T05:00:00Z Bacteria and fungi are especially susceptible to damage by complement proteins, whereas viruses are taken care of by interferons and cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z The immune system, presented with the peptide, learns to recognize the virus and releases cytotoxic T cells and B cells. Merck will help make Johnson & Johnson coronavirus vaccine as rivals team up to help Biden accelerate shots 2021-03-02T05:00:00Z One set consisted of cytotoxic CD8 T cells that express high levels of cancer-killing molecules but that also express ‘immune-checkpoint’ molecules. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z Therefore, if T cells are REGNASE-1 deficient, they are better equipped to sustain high numbers of cytotoxic CD8 T cells in tumours and produce a prolonged antitumour response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z Our pharmaceutical products fall into this latter category because its products are intended to treat cancer and contain cytotoxic agents. HOVERINK BIOTECHNOLOGIES APPOINTS VSTOCK TRANSFER, LLC AS ITS TRANSFER AGENT AND REGISTRAR 2018-07-11T04:00:00Z This is to the advantage of the virus, because without class I expression, cytotoxic T cells have no activity. Anatomy and Physiology 2013-06-19T00:00:00Z The immune system, presented with the peptide, learns to recognize the virus and releases cytotoxic T cells and B cells. Merck will help make Johnson & Johnson coronavirus vaccine as rivals team up to help Biden accelerate shots 2021-03-02T05:00:00Z The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Runx3 programs CD8⁺ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z The ideal population of T cells for use in ACT would infiltrate tumours and accumulate in substantial numbers while retaining cytotoxic function and the capacity for self-renewal2. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair 2017-11-07T05:00:00Z These MHC molecules may then stimulate a cytotoxic T cell immune response, eventually destroying the cell and the pathogen within. Anatomy and Physiology 2013-06-19T00:00:00Z The inflammation-induced IgA+ cells promote the progression to hepatocellular carcinoma by suppressing liver cytotoxic CD8+ T cells that prevent the emergence of this aggressive tumour. Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Runx3 programs CD8⁺ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Yet the differentiation of T cells into cytotoxic CD8 T cells impairs successful retention of the potential to form long-lived memory cells. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z The other 40 percent, which he does not yet provide in house but wants to, is cytotoxic, known as chemotherapy. Doctor gives back and helps town’s cancer patients 2017-06-05T04:00:00Z These sensitized T cells, of the Th1 class, will also activate cytotoxic T cells. Anatomy and Physiology 2013-06-19T00:00:00Z Here, we leverage our ability to recover precise CD4 neoantigens to discover and augment the cytotoxic potential of the neoantigen-specific CD4+ T cells. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens : Nature : Nature Research 2017-03-21T04:00:00Z Compared with men, more NK cells from women exhibited a greater destructive—or cytotoxic—response to leukemia cells, as indicated by significantly higher expression of a protein marker of NK cell activity. A New Clue to Why Women Outlive Men 2016-06-13T04:00:00Z Delivering chemo directly into the abdomen "may improve efficacy by increasing concentration of the cytotoxic agent directly against the tumor in the abdominal cavity," Chuang said. Two-Pronged Chemo Helps Some With Advanced Ovarian Cancer 2016-06-04T04:00:00Z Initially, these targeted therapeutic agents followed the same clinical development pathway as cytotoxic chemotherapy, that is, based on tumour location and histopathology, driven by the notion that molecular aberrations were tumour specific. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z If an ectopic pregnancy is detected early, the embryo’s development can be arrested by the administration of the cytotoxic drug methotrexate, which inhibits the metabolism of folic acid. Anatomy and Physiology 2013-06-19T00:00:00Z Some of these so-called “élite controllers” possess cytotoxic, or killer, T cells that attack virus-producing cells. Can AIDS Be Cured? \| The New Yorker 2014-12-15T05:00:00Z A promising new approach for advanced cancer selectively delivers cytotoxic agents to tumor cells without the collateral damage to normal, healthy tissue. Cleveland Clinic Announces Top 10 Medical Innovations For 2015 2014-10-29T04:00:00Z "I find this drug interesting because it represents an attempt to step beyond the usual cytotoxic agents. But on its own, it's not a remarkable breakthrough," Edelman said. Experimental Drug May Extend Lung Cancer Survival, Study Suggests 2014-05-31T04:00:00Z This assumption was substantially correct for approaches such as cytotoxic chemotherapy that target generic disease mechanisms, and it enabled considerable progress to be made in treating cancer. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z It shares this mechanism with the cytotoxic T cells of the adaptive immune response. Anatomy and Physiology 2013-06-19T00:00:00Z TcA forms a large bell-shaped pentameric structure and enters the membrane like a syringe, forming a translocation channel through which the cytotoxic domain is probably transported into the cytoplasm. Mechanism of Tc toxin action revealed in molecular detail 2014-04-04T18:24:45.845Z In cell culture, for example, an immune cell called a cytotoxic T cell will kill a cancer cell in a matter of minutes. Medical imaging: Removing the blindfold 2013-12-18T18:50:58.412Z DNA integrity is frequently compromised as a result of exposure to cytotoxic agents, as well as the normal wear and tear of cellular processes like transcription and replication. [Perspective] Finding the Right Partner in a 3D Genome 2013-12-12T19:26:06.028Z When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired. [Report] Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse 2013-12-05T18:57:29.425Z Thus, NK and cytotoxic T cells have complementary activities against virally infected cells. Anatomy and Physiology 2013-06-19T00:00:00Z To investigate this, blood samples were collected from the mice and tested for the presence of anti-tumour immune cells, known as cytotoxic T lymphocytes. Cancer research: Of mice and men 2013-11-21T16:03:54Z Experimentally, cytotoxic chemotherapy or radiation treatment increased factors that mediate macrophage trafficking and intratumoral macrophages. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Consistent with this idea, in vitro, microsatellite-instability colorectal cancer cell lines are more sensitive than chromosomally unstable cell lines to a range of different targeted and cytotoxic agents. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z In vitro T cell proliferative responses, natural killer cell cytotoxic activity, immune synapsis formation, and suppressive function of T regulatory cells were normalized. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z The cytotoxic T cell response, though, is key, as it eventually overwhelms the virus and kills infected cells before the virus can complete its replicative cycle. Anatomy and Physiology 2013-06-19T00:00:00Z In patients with diverse tumor types treated on a phase 1 trial, CDC developed within 4 to 8 weeks in most patients; normal cells were resistant to the cytotoxic effects. [Research Articles] Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans 2013-05-15T18:55:05.140Z In breast cancer, assessment of pro- and antitumour immunity revealed that high macrophage content relative to cytotoxic T-cell content was correlated with a worse outcome than those with a low content. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Cells grown in dish cultures are nearly always less resistant to cytotoxic agents than those grown in 3D matrices; the main difference, Zaman says, is the forces they experience. Mechanics: The forces of cancer 2012-11-23T15:20:56.230Z “Youngsters’ brains are more susceptible to the cytotoxic shock of concussions and as a group they tend to recover more slowly. NFL needs to get seriousness of concussions through its head 2012-11-14T02:31:58Z Clonal expansion and the ability of cytotoxic T cells to kill more than one target cell make these cells especially effective against viruses. Anatomy and Physiology 2013-06-19T00:00:00Z Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. Subgroup-specific structural variation across 1,000 medulloblastoma genomes 2012-08-01T17:52:08.330Z This result suggests a positive contribution of cytotoxic T cells to the therapeutic effect. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Normally, cytotoxic T cells destroy only infected cells; T cells that react to molecules native to the body are eliminated before they mature, thus endowing the immune system with tolerance to 'self'. Pathology: Cause and effect 2012-05-22T15:21:12.780Z They compared the number of cytotoxic T cells—which help battle a virus by killing body cells that harbor it—in normal mice and animals missing IL-33. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z All eight patients received cytarabine and anthracycline for induction therapy, and additional cytotoxic chemotherapy for consolidation; treatment histories are summarized in and described in . Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z Survivors are often left with significant neurological, intellectual and physical disabilities secondary to the effects of these nonspecific cytotoxic therapies on the developing brain. Subgroup-specific structural variation across 1,000 medulloblastoma genomes 2012-08-01T17:52:08.330Z Pinschewer and colleagues also tested whether the cells that emit IL-33 are in the right place in the body to influence cytotoxic T cells. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z The genetically altered mice carried 90% fewer cytotoxic T cells targeted against the virus than did normal animals, a deficiency that translated into a weaker immune counterattack. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z Besides expanding the ranks of cytotoxic T cells, IL-33 seems to prime them for combat. 'Danger Signals' From Dying Cells Jolt Immune System Into Action 2012-02-09T19:01:00Z
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