| 单词 | agonist |
| 例句 | Some drugs are “inverse agonists,” which means that they bind to the same area in the brain but produce an opposite response. Perspective | Marijuana gives you the munchies. What about CBD? 2019-01-07T05:00:00Z Hodges has also learned to structure the doses of his medication — including a dopamine inhaler, a receptor agonist patch and extended-release pills — in a way that supports his concert roster. A Pianist Adapts to Life With Parkinson’s Disease 2023-08-07T04:00:00Z However, though drug companies have had some success targeting the Death Receptor-5, no Fas agonists have made it into clinical trials. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z Methadone is a full agonist of the mu opioid receptor, meaning that when the drug meets the receptor in the brain, it activates it, causing a biochemical reaction that leads to euphoria and pain relief. Vivitrol, Used to Fight Opioid Misuse, Has a Major Overdose Problem 2023-09-13T04:00:00Z Several other studies have shown that GLP-1 agonists cause rats to drink less alcohol and produce less dopamine when they do drink, suggesting that the activity is no longer as pleasurable. Could New Weight-Loss Drugs like Ozempic Treat Addiction? 2023-07-12T04:00:00Z But THC is kind of a sloppy agonist and this partial binding creates the fuzziness we call being stoned or high. Cannabis can cause overdoses. Can these drugs reverse it? 2023-03-27T04:00:00Z And one item fit that bill: a new class of drugs — GLP-1 agonists, a type of medication that aids in weight loss but will likely have to be taken for long periods. The biggest, buzziest conference for health care investors convenes amid fears the bubble will burst 2023-01-17T05:00:00Z A Fas agonist could generate a CAR-T bystander effect, in which the treatment destroys cancer cells that lack the molecule the tumor-targeting antibody is designed to hit. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z Puberty blockers, or gonadotropin-releasing hormone agonists, were first approved by the U.S. Health rights for trans people vary widely, proving the need for global health equity 2022-12-06T05:00:00Z Animal evidence so far suggests that GLP-1 agonists don’t affect overall mood, but the medications might work differently in people who already have mood disorders. Could New Weight-Loss Drugs like Ozempic Treat Addiction? 2023-07-12T04:00:00Z That's because naloxone is a competitive receptor antagonist — the opposite of an agonist. Cannabis can cause overdoses. Can these drugs reverse it? 2023-03-27T04:00:00Z These patients pay hundreds, if not thousands, of dollars to access new drugs, called GLP-1 agonists, along with online coaching to encourage healthy habits. Patients complain some obesity care startups offer pills, and not much else 2022-11-17T05:00:00Z The company appears most excited — judging from its messages to investors — about two experimental diabetes pills in the class known as GLP-1 agonists. As Pfizer triples COVID vaccine price, ‘marketing machine’ in overdrive 2022-11-13T05:00:00Z However, THC is just a partial agonist, meaning it doesn't fully activate the receptor. Does pot really make your memory worse? Here's what the science says 2022-10-17T04:00:00Z GLP-1 agonists have proven to be safe in the general population, but common side effects such as nausea could dissuade people from taking the drugs. Could New Weight-Loss Drugs like Ozempic Treat Addiction? 2023-07-12T04:00:00Z Back in 2010, Dr. Sutherland began prescribing what is called opiate agonist therapy, or medication-assisted treatment, to patients who were using street drugs. Fentanyl From the Government? A Vancouver Experiment Aims to Stop Overdoses 2022-07-26T04:00:00Z Which of the following helps an agonist work? Anatomy and Physiology 2013-06-19T00:00:00Z The drugs, known as GnRH agonists, block the brain from releasing key hormones involved in sexual maturation. EXPLAINER: What medical treatments do transgender youth get? 2022-04-21T04:00:00Z Lin et al.3 report structures of the membrane receptor GPR52, a potential drug target for which the putative naturally occurring agonist — the ligand molecule that activates the receptor — is unknown. A self-activating orphan receptor 2020-02-18T05:00:00Z Semaglutide, which was initially developed as a diabetes treatment, is a type of agonist—a substance that binds to specific receptors in the body and prompts a reaction. Could New Weight-Loss Drugs like Ozempic Treat Addiction? 2023-07-12T04:00:00Z “And if you agree on the facts, then there is only one correct side. But in my agonist view of politics, people don’t disagree on facts, but about how to fit them with their values.” The new class war: did a liberal elite pave the way for rise of Trump? 2020-02-02T05:00:00Z Explain how a synergist assists an agonist by being a fixator. Anatomy and Physiology 2013-06-19T00:00:00Z However, the FDA requested further safety data on the agonist at the end of 2018. Analgesia without opioids 2019-09-10T04:00:00Z ECL2 seems to activate the receptor, removing the need for an external agonist. A self-activating orphan receptor 2020-02-18T05:00:00Z Another therapeutic effect of opioid agonist treatments is that they help people in recovery maintain some level of tolerance to opioids, which is helpful for preventing overdose in the event of relapse. Cannabis: Misinformation about CBD can be life-threatening 2019-07-14T04:00:00Z Stigma also contributes to the resistance to using evidence-supported treatment—both stigma against addicted individuals and stigma against agonist medications, due to the persistent myth that they just substitute a new addiction for an old. How Can We Better Support Physicians in Addressing the Opioid Crisis? 2018-08-31T04:00:00Z Although a number of muscles may be involved in an action, the principal muscle involved is called the prime mover, or agonist. Anatomy and Physiology 2013-06-19T00:00:00Z Another approach, being pursued by Nektar Therapeutics in San Francisco, California, deploys a μ-opioid-receptor agonist that was designed to limit its transit across the blood–brain barrier. Analgesia without opioids 2019-09-10T04:00:00Z Remarkably, the authors were then able to form a stable complex of GPR52 with a modified Gs protein in the absence of an agonist, and to obtain the structure of the complex using cryo-electron microscopy. A self-activating orphan receptor 2020-02-18T05:00:00Z When these transmembrane proteins detect extracellular agonist molecules, they transmit signals to the cell interior through G proteins inside the cells. Activation mechanisms for a universal signalling protein 2018-05-01T04:00:00Z Both drugs are “opioid agonists,” meaning they work with the brain’s opioid receptors much like heroin, blocking withdrawal symptoms of the drug without producing the same high as heroin. Wisconsin program helps people overcome heroin addiction 2017-12-22T05:00:00Z If you consider the first action as the knee bending, the hamstrings would be called the agonists and the quadriceps femoris would then be called the antagonists. Anatomy and Physiology 2013-06-19T00:00:00Z Partial agonists induce changes at receptors, but not to the same degree as do full agonists. Analgesia without opioids 2019-09-10T04:00:00Z By contrast, the discovery of a tethered agonist that helps to maintain GPR52 in the active state in the absence of an external agonist is truly striking. A self-activating orphan receptor 2020-02-18T05:00:00Z Beck was put on standard Parkinson’s medication, called dopamine agonists, that helped restore his body movement. Was a spy’s Parkinson’s disease caused by a secret microwave weapon attack? 2017-11-26T05:00:00Z Although non-prescription melatonin is by far the most popular, some children are prescribed epilepsy drugs, sedatives, alpha agonists such as clonidine or antidepressants such as trazodone, depending on the nature of their problem. How to Get Children with Autism to Sleep 2017-11-18T05:00:00Z See Table 11.1 for a list of some agonists and antagonists. Anatomy and Physiology 2013-06-19T00:00:00Z An optimal dose works as a partial agonist for opioid receptors in the brain, meaning it helps control cravings and withdrawal symptoms without producing the euphoric high that drives addiction. Engulfed in Opioid Deaths, Ohio Turns to Science 2017-10-19T04:00:00Z The new findings raise the intriguing possibility that, for at least some oGPCRs, the incorporation of agonists within the receptor itself obviates the need for external ligands. A self-activating orphan receptor 2020-02-18T05:00:00Z Occasionally, if a child is abnormally precocious, parents can delay puberty by using GnRH agonists, which stop the pituitary from producing the hormones that trigger gonadal development. Puberty: Early starters : Nature : Nature Research 2017-10-03T04:00:00Z A few drugs, such as the dopamine agonists used to treat Parkinson's disease, have the opposite effect. Sexual arousal: Sex matters : Nature : Nature Research 2017-10-03T04:00:00Z Phenylephrine is known as an α1-adrenergic agonist, meaning that it binds to a specific adrenergic receptor, stimulating a response. Anatomy and Physiology 2013-06-19T00:00:00Z Borrowing the term for a compound that boosts the effect of a neurotransmitter, he speculates that peyote serves as a "humility agonist," counteracting his arrogance by instilling awe and reverence in him. Tripping on Peyote in Navajo Nation 2017-07-08T04:00:00Z And cannabinoid receptor agonists – which, as their name suggests, are a derivative of cannabis – may have potential, too. New (and Old) Ways to Battle Pain 2016-09-20T04:00:00Z The GnRH agonists are injected or implanted in the skin, but they should not be used for too long, or at too late an age. Puberty: Early starters : Nature : Nature Research 2017-10-03T04:00:00Z In addition, the patients continued to use high-dose inhaled corticosteroids and long-acting beta agonists inhalers to control their asthma. New Biologic Drug Tackles Hard-to-Control Asthma 2016-09-07T04:00:00Z Parasympathetic drugs can be either muscarinic agonists or antagonists, or have indirect effects on the cholinergic system. Anatomy and Physiology 2013-06-19T00:00:00Z Tegaserod is a 5-HT4 receptor agonist — rather than blocking the receptor, the drug activates it and increases the signals sent to the circular muscles that wrap around the colon, speeding transit. Drug development: A healthy pipeline : Nature : Nature Publishing Group 2016-05-17T04:00:00Z Uptravi, among a class of drugs called oral IP prostacyclin receptor agonists, relaxes and opens blood vessels, easing the elevated pressure, the agency said. Uptravi Approved for Chronic Lung Disease 2015-12-22T05:00:00Z Salvinorin A is a selective kappa opioid receptor agonist, which is unlike any other psychoactive substance. Traditional Medicine from Southern Mexico Offers Help with Addiction 2015-08-11T04:00:00Z This drug, from a class called "glucagon-peptide receptor agonists," shouldn't be used in combination with other drugs in that class. Saxenda Approved for Weight Loss 2014-12-24T05:00:00Z Pilocarpine is a nonspecific muscarinic agonist commonly used to treat disorders of the eye. Anatomy and Physiology 2013-06-19T00:00:00Z More than 60 percent of the time, the impulse control cases involving dopamine receptor agonists were patients struggling with Parkinson's, while nearly a quarter involved patients with restless leg syndrome, the researchers said. Parkinson's Drugs May Spur Compulsive Behaviors 2014-10-20T04:00:00Z They found that seniors taking both medications had 8 percent fewer deaths and hospitalizations during this period, compared with those taking long-acting beta agonists alone, a result they called modest but significant. Treating C.O.P.D. in the Elderly 2014-10-13T04:00:00Z Researchers found that about 37.3 percent of people died while using beta agonists alone, compared with 36.4 percent of people using the combination therapy. Combo Therapy Best for COPD: Study 2014-09-16T04:00:00Z “It’s almost hard to imagine that it could be related to the partial vs. full agonist aspect of the drug.” 6 Reasons Synthetic Marijuana (Spice, K2) Is So Toxic To The Brain 2014-08-28T04:00:00Z The injected biotech drug, from a class known as integrin receptor agonists, works by blocking circulating inflammatory cells from reaching areas of inflammation in the digestive tract. F.D.A. Clears New Drug to Treat Colitis and Crohn’s 2014-05-21T04:00:00Z According to the American Parkinson Disease Association, these medicines are part of a powerful and effective class of drugs known as dopamine receptor agonists. Parkinson's Drugs May Spur Compulsive Behaviors 2014-10-20T04:00:00Z When they took the two medications instead of one, their risk of hospitalization and death was 16 percent lower, compared with people with both conditions who took only long-acting beta agonists. Treating C.O.P.D. in the Elderly 2014-10-13T04:00:00Z Overall, the use of combination therapy reduced risk of death or hospitalization by 3.7 percent, compared with beta agonists alone, the study found. Combo Therapy Best for COPD: Study 2014-09-16T04:00:00Z Unfortunately, says Seale, no equivalent agonist has been found in humans and the search has largely been abandoned by pharmaceutical companies. Cell physiology: The changing colour of fat 2014-04-16T17:21:54.590Z The drug is a combination of UMEC, a long-acting muscarinic antagonist, and VI, a long-acting beta agonist, in a single inhaler. GlaxoSmithKline's COPD drug Anoro receives European green light 2014-02-20T13:30:40Z Overall, dopamine agonists demonstrated larger effects on symptoms than did anticonvulsants or opioids. Restless legs syndrome, often misdiagnosed, may affect as many as one in 10 adults 2013-12-09T20:21:53Z For their new study, researchers in Ontario combed through records of all adults ages 66 and older with C.O.P.D. who had started taking two types of medications: long-acting beta agonists and inhaled corticosteroids. Treating C.O.P.D. in the Elderly 2014-10-13T04:00:00Z The adrenaline receptor agonist salbutamol, for example, was first approved 45 years ago and remains one of the most effective agents for asthma. Drug Discovery: Structure-led design 2013-10-16T17:21:21.530Z "You will see lameness even in normal feedlots in animals that are not given beta agonists," Varma said. Merck says no safety issues found in Zilmax cattle product 2013-08-16T17:33:57Z But the economic benefits of using Zilmax and some other beta agonist drugs is being diminished by mounting criticism. Tyson takes lead with Zilmax ban, higher beef prices may follow 2013-08-09T04:06:59Z Evaluation of the microglial response to nuclear receptor agonists in vivo is hampered by the lack of robust and reproducible measures of drug action in this cell type. [Technical Response] Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” 2013-05-23T18:26:03.153Z “We use H3-receptor antagonist to treat excessive daytime sleepiness disorders such as narcolepsy, but we think that an H3-receptor agonist could be very useful for insomnia,” Lin says. Insomnia: Chasing the dream 2013-05-22T17:21:47.147Z The drug also met all its secondary goals, such as improving symptoms and lung function and reducing the need for standard drugs called beta agonists. Regeneron, Sanofi asthma drug seen as potential game changer 2013-05-21T12:16:49Z Varma said, however, that the company plans to conduct several studies to better understand whether Zilmax, a beta agonist medicine used to increase weight in cattle headed for slaughter, is causing lameness in animals. Merck says no safety issues found in Zilmax cattle product 2013-08-16T17:33:57Z Of the 73 new chemicals that were discovered last year 50 were cannabinoid receptor agonists, often developed for use in legitimate pharmaceutical research known as "structure-activity relationship" tests. Online highs are old as the net: the first e-commerce was a drugs deal 2013-04-19T13:51:53Z The basis for the inconsistent induction of microglial phagocytosis by nuclear receptor agonists is unclear but appears to vary as a function of age, genotype, diet, drug administration schedules, and other unknown variables. [Technical Response] Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” 2013-05-23T18:26:03.153Z “As a drug target, it is in the proof of concept stage, but we have candidate agonists in development,” he adds. Insomnia: Chasing the dream 2013-05-22T17:21:47.147Z All patients initially stayed on their standard asthma treatments, meaning medium-to-high doses of inhaled glucocorticoids, as well as long-acting beta agonists. Regeneron, Sanofi asthma drug seen as potential game changer 2013-05-21T12:16:49Z One of the most effective interventions for opiate addictions, in particular, are medications, including the opiate agonists and partial agonists methadone and Suboxone. Viewpoint: Why We Need to Rethink Rehab 2013-04-03T10:50:20Z The fMRI was to look at the level of connectivity in the fronto-striatal circuit, while the PET scan used radioligand bound dopamine receptor agonists to look at the concentrations of D2 receptors in the striatum. The Superiority Illusion: where everyone is above average 2013-04-01T13:15:21.400Z In this context, it has been reported that many of the autoantibodies that behave like agonists recognize the extracellular region of the receptor in diverse human diseases such as in Graves’ disease. Molecular signatures of G-protein-coupled receptors 2013-02-13T18:21:29.900Z Remarkably, functional selectivity can even lead to the exact same molecule acting alternatively as an agonist or antagonist, depending on the physiological response that is being mediated by the protein. G Protein-Coupled Receptors (GPCRs) win 2012 Nobel Prize in Chemistry 2012-10-10T13:45:00.463Z These data suggest that phosphorylated AR agonists may serve as a promising new group of drugs for targeted immunotherapy of inflammation. [Research Articles] Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis 2012-08-08T18:55:12.537Z Drugs called dopamine agonists are sometimes prescribed for both RLS and Parkinson's independently. No extra restless legs syndrome in Parkinson's 2011-11-09T22:34:12Z Exenatide, marketed under the name Byetta, is derived from the saliva of the Gila monster lizard and was the first approved drug in the class known as GLP1 agonists, which stimulate insulin secretion. Prescriptions Blog: Amylin and Eli Lilly Part Ways Over Diabetes Drug 2011-11-08T17:08:22Z Although these findings are consistent with the X-ray structures of the active states, some of the structures of β-ARs bound to agonists were observed to be in the inactive conformation. Molecular signatures of G-protein-coupled receptors 2013-02-13T18:21:29.900Z "This is the first report of a selective S1P1 receptor agonist reporting a statistically significant treatment effect in patients suffering from relapsing multiple sclerosis," said Martin Clozel, Actelion's managing director and chief scientific officer. Drug cuts brain lesions in MS patients: Actelion study 2011-08-02T05:33:38Z Moreover, increased variable domain diversity in response to the use of TLR agonist–based adjuvants correlated with improved antigen neutralization. [Research Articles] Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine 2011-07-27T18:55:20.493Z An American study was later published reporting a link between compulsive behaviour and treatment with low doses of dopamine agonist drugs. Drug in gambling addiction claim 2011-02-03T15:08:17Z At present, the long- and short-acting inhalers relied on by the 23 million asthmatics in the U.S. belong to the same family, called "beta agonists." Discovery could lead to new asthma treatments 2010-10-25T16:48:00Z Furthermore, in AR, agonist binding induces a 2 Å shift of TM3 along its axis and towards the extracellular side. Molecular signatures of G-protein-coupled receptors 2013-02-13T18:21:29.900Z These included: Spiriva plus an inhaled steroid; a double dose of the inhaled steroid; and an inhaled steroid plus Serevent, a long-acting beta agonist that relaxes the muscles in the airway. Early Trial Suggests COPD Drug Might Help Some Asthmatics 2010-09-19T13:00:00Z "It confirms that dopamine agonist treatment is associated with one or more impulse control disorders in patients with Parkinson's disease," he said. Parkinson's drugs linked with compulsive behaviors 2010-05-10T21:02:00Z Other classes of medications, like the so-called alpha agonists, like guanfacine or clonidine, are also sometimes used, but the evidence is weaker for these drugs. 2010-02-17T17:07:00Z In seconds, the airways expanded to 90 percent of their original volume — three times as much as they did with the beta 2 agonist inhalant. Discovery could lead to new asthma treatments 2010-10-25T16:48:00Z Reproach she looks, about, above, Denied her light, denied her love, Denied for what she sacrificed, Doomed to be fruitless agonist. Helen Redeemed and Other Poems Sometimes, one glimpses a little too long behind his work not the heroic agonist, but the man who loved to languish in mournful salons, attired in furred dressing gowns. Musical Portraits Interpretations of Twenty Modern Composers How beautiful are the bodies of men— The agonists! Toward the Gulf |
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