| 单词 | clotting factor |
| 例句 | Slavin was born a hemophiliac in the 1950s, when the only available treatment involved infusions of clotting factors from donor blood, which wasn’t screened for diseases. The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z The blood has been stripped of its clotting factors. The Hot Zone 1994-01-01T00:00:00Z This blood keeps running, because _the clotting factors have been used up. The Hot Zone 1994-01-01T00:00:00Z Also, your clotting factors are elevated from the pregnancy hormones; that along with being dehydrated, your blood becomes more viscous, more prone to blood clots. Tips for Traveling While Pregnant 2014-11-20T05:00:00Z The syndrome affects the clotting factors and platelet aggregation. Biology for AP Courses 2022-06-09T00:00:00Z The findings, published in the New England Journal of Medicine, showed nine out of 10 patients given the therapy no longer needed their clotting factor IX injections. Transformational therapy cures haemophilia B 2022-07-20T04:00:00Z Hemostasis involves three basic steps: vascular spasm, the formation of a platelet plug, and coagulation, in which clotting factors promote the formation of a fibrin clot. Anatomy and Physiology 2013-06-19T00:00:00Z Donated plasma is most commonly used to treat patients with clotting factor disorders such as hemophilia and von Willebrand disease. Blood plasma isn’t effective therapy for covid, but it’s vital for other illnesses 2021-12-10T05:00:00Z Their hope was that it would be enough to stabilize the clotting factor and prevent it from binding to the body’s own VWF. New fusion protein treatment holds promise for people with ‘royal’ clotting disorder 2020-09-09T04:00:00Z Insulin activation activates other clotting factors until a fibrin clot is produced. Biology for AP Courses 2022-06-09T00:00:00Z Those include COVID-19—because severe cases feature a storm of immune cells, clotting factors, and other inflammatory signals in the blood. Newly identified cell type may help predict, treat rheumatoid arthritis flares 2020-07-17T04:00:00Z Serum, one of the specimen types included, refers to a sample of plasma after clotting factors have been removed. Anatomy and Physiology 2013-06-19T00:00:00Z The other 10 percent is proteins, minerals, nutrients, hormones, waste products, clotting factors, and in the case of patients who have recovered from a viral illness, antibodies. Blood plasma isn’t effective therapy for covid, but it’s vital for other illnesses 2021-12-10T05:00:00Z When injured, they send out a complex array of signals to immune cells and clotting factors, which rush to repair the site. Blood vessel attack could trigger coronavirus’ fatal ‘second phase’ 2020-06-02T04:00:00Z Blood clotting is maintained by a positive feedback loop, as clotting factors are maintained in a specific range and a positive loop helps return the conditions to the set point. Biology for AP Courses 2022-06-09T00:00:00Z The freezers in Levy’s lab are filled with thousands of samples of serum, the liquid component of blood after cells and clotting factors are removed. Tailoring vaccines for older people and the very young 2019-11-26T05:00:00Z Not only are the pathogens killed and debris removed, but the increase in vascular permeability encourages the entry of clotting factors, the first step towards wound repair. Anatomy and Physiology 2013-06-19T00:00:00Z When healthy people cut themselves or experience blood loss as a result of injury or surgery, their body’s clotting factors ensure that they do not lose too much blood. Blood plasma isn’t effective therapy for covid, but it’s vital for other illnesses 2021-12-10T05:00:00Z The endothelial and immune cells add fuel to the fire, recruiting additional clotting factors and platelets, which help form clots. Blood vessel attack could trigger coronavirus’ fatal ‘second phase’ 2020-06-02T04:00:00Z Blood plays a protective role by transporting clotting factors and platelets to prevent blood loss and transporting the disease-fighting agents or white blood cells to sites of infection. Biology for AP Courses 2022-06-09T00:00:00Z Tom Fearns said Jack receives clotting factor concentrates intravenously to replace the blood clotting factor missing from his body. UK boy with severe, unexplained bruising diagnosed with rare blood disorder after parents accused of abuse 2019-07-26T04:00:00Z It packages nutrients absorbed by the digestive system; produces plasma proteins, clotting factors, and bile; and disposes of worn-out cell components and waste products. Anatomy and Physiology 2013-06-19T00:00:00Z Plasma also contains clotting factors that can be used to help treat haemophilia, and albumin, a protein that can be used to help heal burns. Should we pay people for donating blood or not? 2018-11-14T05:00:00Z Such compartments would also need to be able to release certain molecules, such as factor V or the von Willebrand clotting factor. Which biological systems should be engineered? 2018-11-05T05:00:00Z Many of the clotting factors require vitamin K to work, and vitamin K deficiency can lead to problems with blood clotting. Biology for AP Courses 2022-06-09T00:00:00Z This could threaten reliable cash flows for clotting factor makers as well as pose a challenge to Hemlibra. With Hemlibra, Roche seeks to break into tight hemophilia circle 2018-10-03T04:00:00Z Some recent evidence indicates that activation of various clotting factors occurs on specific receptor sites on the surfaces of platelets. Anatomy and Physiology 2013-06-19T00:00:00Z However, fresh frozen plasma is less commonly used now and haemophiliacs are generally treated with synthetic clotting factors. Reality Check: Does the UK import blood? 2018-09-27T04:00:00Z The standard treatment, infusions of the missing clotting factor, is expensive. Opinion | When Medical Innovation Meets Politics 2018-08-24T04:00:00Z The platelets collect at a wound site in conjunction with other clotting factors, such as fibrinogen, to form a fibrin clot that prevents blood loss and allows the wound to heal. Biology for AP Courses 2022-06-09T00:00:00Z Shire fears losing 30 percent of its $2.4 billion annual clotting factors sales to Hemlibra in the short term, court documents show. With Hemlibra, Roche seeks to break into tight hemophilia circle 2018-10-03T04:00:00Z This process also wrings out of the clot a small amount of fluid called serum, which is blood plasma without its clotting factors. Anatomy and Physiology 2013-06-19T00:00:00Z The goal of gene therapy is to reduce or eliminate patients’ need for injections with clotting factor and to reduce the number of bleeds. They Thought Hemophilia Was a ‘Lifelong Thing.’ They May Be Wrong. 2018-08-13T04:00:00Z But, in addition, doctors are prescribing ever more clotting factor for prevention of joint-damaging bleeds and for improved long-term health. Case of the $21-million Medicaid patient shows how drug prices soar for rare diseases 2018-03-05T05:00:00Z Platelets and blood clotting factors cause the change of the soluble protein fibrinogen to the insoluble protein fibrin at a wound site forming a plug. Biology for AP Courses 2022-06-09T00:00:00Z Like 2,000 other people in the UK, his body could not make clotting factor VIII. Haemophilia trial's 'mind-blowing' result 2017-12-13T05:00:00Z For instance, a cluster of proteins collectively referred to as the protein C system inactivates clotting factors involved in the intrinsic pathway. Anatomy and Physiology 2013-06-19T00:00:00Z He has not given himself a shot of clotting factor since the procedure. They Thought Hemophilia Was a ‘Lifelong Thing.’ They May Be Wrong. 2018-08-13T04:00:00Z For the current trial, which is being funded by Spark and Pfizer, researchers used a clotting factor that is 8 to 10 times as strong as the normal version. Gene therapy makes a big advance treating hemophilia B blood disorder 2017-12-06T05:00:00Z As one clotting factor is activated, it activates the next factor in sequence until a fibrin clot is achieved. Biology for AP Courses 2022-06-09T00:00:00Z Nine of the 10 no longer need clotting factor treatments, and the 10th needs far fewer of them. Gene therapy shows promise against blood-clotting disease 2017-12-06T05:00:00Z Another reason for failure of the blood to clot is the inadequate production of functional amounts of one or more clotting factors. Anatomy and Physiology 2013-06-19T00:00:00Z No longer are scientists and patients dazzled by a treatment that raises blood clotting factor levels merely to 6 percent of average. They Thought Hemophilia Was a ‘Lifelong Thing.’ They May Be Wrong. 2018-08-13T04:00:00Z The gene is transported to the liver, where clotting factor is made, by a harmless virus called an adeno-associated viral vector. Gene therapy makes a big advance treating hemophilia B blood disorder 2017-12-06T05:00:00Z Blood clotting is maintained by a positive feedback loop, as clotting is amplified in response by increasing the amount of clotting factors when clotting factors are present. Biology for AP Courses 2022-06-09T00:00:00Z Before, even small amounts of exertion would cause tiny muscle tears and bleeding problems requiring clotting factor treatment. Gene therapy shows promise against blood-clotting disease 2017-12-06T05:00:00Z Regular infusions of clotting factors isolated from healthy donors can help prevent bleeding in hemophiliac patients. Anatomy and Physiology 2013-06-19T00:00:00Z Plasma clotting factors were used by American hemophiliacs, many of whom died of AIDS. H.I.V. Arrived in the U.S. Long Before ‘Patient Zero’ 2016-10-26T04:00:00Z Almost immediately, he began producing the missing clotting factor. Gene therapy makes a big advance treating hemophilia B blood disorder 2017-12-06T05:00:00Z Hemophilia is a rare condition in which the blood lacks sufficient clotting factors. Biology for AP Courses 2022-06-09T00:00:00Z Food and Drug Administration to replace a deficient blood clotting factor among people with hemophilia B. Idelvion Approved for Hemophilia B 2016-03-07T05:00:00Z Inadequate clotting can result from too few platelets, or inadequate production of clotting factors, for instance, in the genetic disorder hemophilia. Anatomy and Physiology 2013-06-19T00:00:00Z Some say that the “hemocaust,” when many hemophiliacs died from H.I.V. or hepatitis from tainted clotting factors, still influences the community. Hemophilia Patient or Drug Seller? Dual Role Creates Ethical Quandary 2016-01-13T05:00:00Z On Wednesday, researchers reported that a single intravenous infusion of Spark's novel gene therapy enabled patients to safely produce sufficient clotting factor to prevent dangerous bleeding episodes. Gene therapy makes a big advance treating hemophilia B blood disorder 2017-12-06T05:00:00Z Existing haemophilia treatments tip the balance towards clotting by adding what the body lacks—the clotting factor that is missing or defective. Time for a ‘Completely Different’ Haemophilia Treatment? 2015-01-12T05:00:00Z Research is also moving ahead on an alternative treatment strategy to remove or disable the body's anticoagulants rather than adding clotting factors. Special report: The New Science of Haemophilia 2014-12-22T05:00:00Z Rather than infusing functional clotting factors, the therapy aims to get the body to create its own. Gene therapy: Genie in a vector : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Biogen, a newcomer, entered the market with clotting factors that require less frequent infusions. Hemophilia Patient or Drug Seller? Dual Role Creates Ethical Quandary 2016-01-13T05:00:00Z The one patient who needed clotting factor because of bleeding used 91 percent less than before, she said. Gene therapy makes a big advance treating hemophilia B blood disorder 2017-12-06T05:00:00Z When patients have an infusion of clotting factor every 48 hours, the concentration of clotting factor initially reaches 100% of normal levels and stays there for about 12 hours. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Existing haemophilia treatments tip the balance towards clotting by adding what the body lacks — the clotting factor that is missing or defective. Thrombosis: Balancing act : Nature : Nature Publishing Group 2014-11-25T05:00:00Z When damage occurs to blood vessels, exposure of the blood to collagen in the cell walls and material released by the cells triggers the activation of clotting factors. Born in the blood : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The method worked because “there are some clotting factors in the pork … and the high level of salt will pull in a lot of fluid from the nose,” she said. Ig Nobel winner: Using pork to stop nosebleeds 2014-09-18T04:00:00Z “There are some clotting factors in the pork,” she said, the Associated Press reports, “and the high level of salt will pull in a lot of fluid from the nose.” Could Bacon Stop Nosebleeds? 2014-09-19T04:00:00Z Drug companies have responded with clotting factors that last longer, making the time between infusions greater. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z About half of the association between stroke and AB blood type in the previous study was related to higher levels of clotting factor VIII, a blood protein that helps blood clot to stop bleeding. Study: Rare Blood Type May Slightly Raise Dementia Risk 2014-09-10T04:00:00Z A year later, a manufactured form of clotting factor became available, and my brother finally had real medicine that could stave off the constant internal bleeding in his system. My Mother’s Miracle-Water Cure 2014-07-11T04:00:00Z A person with severe hemophilia may use up to 5,000 units of clotting factor a week. Health Highlights: May 13, 2014 2014-05-13T04:00:00Z Hemophilia is a hereditary disorder that prevents blood from clotting properly due to lack of a clotting factor protein in the blood. Exclusive: Biogen prices hemophilia drug on par with older therapies 2014-04-18T17:04:29Z A similar approach, which is being pursued by CSL Behring, based in King of Prussia, Pennsylvania, is to fuse the clotting factors with albumin. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Hemophilia A is caused by a lack of clotting factor VIII, while hemophilia B is caused by a lack of clotting factor IX. New hemophilia drugs aim to simplify treatment 2014-03-07T12:06:46Z To stay alive, hemophiliacs often require transfusions of the clotting factor. A Conversation With Holbrook Kohrt: A Doctor’s Intimate View of Hemophilia 2013-12-23T22:51:43Z There are many proteins, chemicals and clotting factors in blood that are normally in balance, allowing your blood to flow properly and nourish your cells. Anticlotting Drugs: What You Need to Know 2013-08-31T12:00:00Z Patients with more severe hemophilia require larger and more frequent doses of blood clotting factors. Exclusive: Biogen prices hemophilia drug on par with older therapies 2014-04-18T17:04:29Z Powell says that the albumin seems somehow to interfere with the normal activity of that clotting factor. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Meanwhile, biotechnology companies like Sangamo BioSciences and BioMarin Pharmaceutical are working on methods to replace defective hemophilia genes, allowing patients to begin producing their own clotting factor. New hemophilia drugs aim to simplify treatment 2014-03-07T12:06:46Z They included various components of cholesterol, blood pressure, blood clotting factors and molecules that are signals of inflammation. Hysterectomy not tied to heart risk factors: study 2013-05-14T21:01:25Z Some have documented the increased inflammation that pollution can trigger, as well as changes in blood pressure and the activity of clotting factors in the blood that could promote heart heart disease. Is Air Pollution Contributing To Hardened Arteries? 2013-04-28T15:20:40Z New drugs interfere with blood clotting factors at a later stage in the coagulation cascade. Physiology: Beating stroke 2013-01-30T18:23:09.067Z PEG is eventually flushed from the body through the kidneys and liver, but before then it gives the clotting factors a new lease of life. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z A single injection of the long-lasting clotting factor, being developed in partnership with Swedish Orphan Biovitrum, controlled bleeding in 90.4 percent of all episodes. Biogen's hemophilia drug meets late-stage trial goal 2012-09-26T20:40:09Z A single injection of the long-lasting clotting factor, being developed in partnership with Swedish Orphan Biovitrum, controlled bleeding in 90.4 percent of all bleeding episodes. Biogen's hemophilia drug meets late-stage trial goal 2012-09-26T14:24:15Z I’d still be taking clotting factor every day and be addicted to caffeine. UGS (Universal Genome Sequencing) in the Mid-21st Century 2012-06-09T18:45:02.963Z Traditional hemorrhage treatment — giving intravenous saline solution to restore blood pressure — actually killed patients, he said, because it diluted clotting factors. Tranexamic Acid, Cheap Drug, Is Found to Staunch Bleeding 2012-03-21T02:52:33Z By the end of the 1960s, freeze-dried concentrates of clotting factors were available for home use, to prevent spontaneous bleeding. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Matthew Jajeh, 16, injects himself with clotting factor to help his blood clot. Well Blog: Patient Voices: Hemophilia 2012-01-25T20:23:32Z The two main forms of the disease are hemophilia A, caused by a lack of clotting factor VIII, and hemophilia B, caused by a lack of clotting factor IX. Gene therapy proves effective for hemophilia B 2011-12-11T03:11:57Z Patients in the study, whose bodies produced less than 1 percent of the normal amount of clotting factor IX, were getting injections of the standard treatment. Gene Therapy Allows Hemophiliacs to Skip Weekly Shots in Study 2011-12-10T17:35:08Z Hemophilia B is much less common than hemophilia A, a deficiency of clotting factor VIII. Gene therapy proves effective for hemophilia B 2011-12-10T16:12:22Z Extending the life of clotting factors may improve quality of life for people with haemophilia. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The disease primarily affects men, and patients with hemophilia take injections of a clotting factor to prevent or reduce bleeding episodes. Well Blog: Patient Voices: Hemophilia 2012-01-25T20:23:32Z Researchers have so far treated six men with severe hemophilia B who were producing clotting factor IX at less than 1 percent of normal levels. Gene therapy proves effective for hemophilia B 2011-12-11T03:11:57Z Patients with hemophilia lack, or are deficient in, certain proteins called clotting factors that help stop bleeding. Biogen to build blood disorder drug franchise 2011-03-04T16:42:26Z Haemotoxins affect the blood, either by rupturing red blood cells and causing massive internal bleeding, or ramping up clotting factors leading to blockages within vessels and arteries potentially leading to strokes and death. Biting the Hand That Feeds: Evolution of snake venom 2011-01-26T16:45:02.727Z Other versions of the clotting factors from other drug developers are showing similar extensions of lifetimes. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Warfarin patients can get an infusion of Vitamin K or other clotting factors to speed the process. New bloodthinners thicken the drug market 2010-11-22T21:32:00Z The latter consists of water, sugars, salts and proteins, including the "clotting factors" that trigger a cascade of reactions ending with the formation of a blood clot. U.S. military medics use old and new techniques to save wounded in Afghanistan 2010-11-01T21:13:00Z The two main forms of the disease are hemophilia A, caused by a lack of clotting factor VIII, and the less-common hemophilia B, caused by a lack of clotting factor IX. Biogen to build blood disorder drug franchise 2011-03-04T16:42:26Z Hemophilia is treated with replacement therapy; the missing clotting factor is provided as a concentrate injected or infused into the blood. 18 and Under: When a Scratch or a Nosebleed Turns Into a Flood 2010-03-08T23:05:00Z The trick to extending the half-lives of clotting factors is to interfere with the body's natural mechanisms for flushing them away. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Biogen is developing clotting factors to treat haemophilia, an inherited disorder that impairs blood's ability to clot. UPDATE 1-Biogen gets manufacturing rights for hemophilia therapy 2010-02-18T08:24:00Z There are three very similar approaches, each of which extends half-life by about the same amount for the respective clotting factors. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The clotting factors do not last very long in the body. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z Still, there would be substantial benefit from a less-than-perfect level of clotting factor. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z |
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