| 单词 | clonal |
| 例句 | The vineyard now has six acres of nebbiolo, comprising seven different clonal selections, each a mutation of nebbiolo with subtly different characteristics. Leaving It All Behind for the Love of Nebbiolo 2019-03-07T05:00:00Z The single-rooted Aspen-tree colony is a vast clonal organism — its name is Latin for “I spread” — thought to be at least 80,000 years old and now at risk of death. In the galleries: The beauty of nature, in all its horror 2016-04-28T04:00:00Z “Looking at the artworks in this book,” Gollner writes, “is the visual equivalent of tasting the incredible diversity of fruit grown at these clonal germplasm repositories.” Perspective | These U.S. Agriculture Department paintings of fruits and nuts are actually stunning 2021-06-21T04:00:00Z Modern orchards, with their reliance on dwarf trees, varietal selections, clonal rootstocks and chemically supported monocultures, are weak and practically require industrial crutches. The Best Wine Books Are Not Always About Wine 2019-11-27T05:00:00Z “The one tumor-one gene-one drug approach oversimplified cancer biology and did not take into account tumor heterogeneity, clonal evolution, or other mechanisms of resistance,” ComboMATCH’s leaders wrote in an April paper. U.S. study will test whether drug combinations can wipe out tumors 2023-06-01T04:00:00Z Because of the time required to generate a population of clonal T and B cells, there is a delay in the adaptive immune response compared to the innate immune response. Concepts of Biology 2013-04-25T00:00:00Z It was a groundbreaking achievement, but the plants weren’t perfect: Only about 30% of their seeds were clonal. ‘Game changer.’ Scientists are genetically engineering crops to clone themselves 2023-05-17T04:00:00Z Whereas most ant species have a queen that lays eggs while workers gather food for her and the colony’s young, as well as themselves, clonal raiders lack queens. Lazy worker ants sprout queenlike wings and sponge off other workers 2023-03-05T05:00:00Z She had plucked pupae from a colony of clonal raider ants, where the sesame seed-size offspring that looked like puffed rice cereal were being fussed over by both younger larvae and older adult ants. Ant Milk: It Does a Colony Good 2022-11-30T05:00:00Z Then there are clonal trees, genetically identical trees that share a root system such as Sweden’s Old Tjikko and the Pando colony of aspens in Utah. Why mystery surrounds what may be Earth’s oldest tree 2022-10-16T04:00:00Z The activation of B cells corresponding to one specific BCR variant and the dramatic proliferation of that variant is known as clonal selection. Biology for AP Courses 2022-06-09T00:00:00Z The group is now looking for funding to test its clonal rice in field trials, says co-author Emmanuel Guiderdoni, a rice geneticist at the French Agricultural Research Centre for International Development. ‘Game changer.’ Scientists are genetically engineering crops to clone themselves 2023-05-17T04:00:00Z In contrast, the transition in this single clonal raider colony only took one generation, making it much easier to study. Lazy worker ants sprout queenlike wings and sponge off other workers 2023-03-05T05:00:00Z This is an important feature of the immune response, because if clonal expansion during immune responses were allowed to continue uncontrolled, these responses could lead to autoimmune diseases and other medical issues. Anatomy and Physiology 2013-06-19T00:00:00Z He notes that Y. pestis strains are “notoriously clonal,” or nearly identical, and slow to evolve. Ancient Women’s Teeth Reveal Origins of 14-Century Black Death 2022-06-15T04:00:00Z Instead, the plants must be regenerated as a clonal organisms, such as potatoes, from plantlets growing in sterile test tubes. World’s largest bean and cassava collection gets a striking new home 2022-03-20T04:00:00Z The researchers want to see how their clonal plants fare in harsher conditions than they experienced in the greenhouse. ‘Game changer.’ Scientists are genetically engineering crops to clone themselves 2023-05-17T04:00:00Z Now a study has identified another, unexpected source of protection: clonal hematopoiesis, a blood cell imbalance best known as a risk factor for cancer and heart disease. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z In the process of clonal deletion, immature B cells that bind strongly to self-antigens expressed on tissues are signaled to commit suicide by apoptosis, removing them from the population. Anatomy and Physiology 2013-06-19T00:00:00Z He wanted to study clonal hematopoiesis of indeterminate potential, or CHIP, a common but poorly understood condition that is common in older people and increases the risk for cancer and heart disease. Stamping Bar Codes on Cells to Solve Medical Mysteries 2021-11-29T05:00:00Z For instance, he says, intense grazing in grasslands could suppress flowering and boost clonal growth instead, which would reduce diversity. Seagrass has more sex when otters are around 2021-10-13T04:00:00Z Pando, a 106-acre clonal colony of genetically identical aspen trees connected by a single root system in Utah, is thought to have sustained itself for as long as 14,000 years and counting. How Long Can We Live? 2021-04-28T04:00:00Z Given the negative health effects of clonal hematopoiesis, inducing it in healthy people is a nonstarter. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z In the process of clonal anergy, however, B cells exposed to soluble antigen in the bone marrow are not physically deleted, but become unable to function. Anatomy and Physiology 2013-06-19T00:00:00Z Few social insects are as homogenous as clonal ants, but in most, queens and workers have very similar genomes, because all colony members are offspring of one or several queens. What can ants, bees, and other social insects teach us about aging? 2021-03-25T04:00:00Z A remarkable finding is that each endometrial gland seems to be clonal — that is, all the cells in the gland are derived from a single epithelial progenitor cell. A catalogue of cancer-driving mutations in healthy tissue 2020-04-21T04:00:00Z This phenomenon, called a clonal sweep, occurs in recurring cycles during cancer growth. Global genomics project unravels cancer’s complexity at unprecedented scale 2020-02-04T05:00:00Z But clonal hematopoiesis results from competition among the 50,000 to 200,000 stem cells that dwell there and divide to produce all our red and white blood cells. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z The final B cell of interest is the memory B cell, which results from the clonal expansion of an activated B cell. Anatomy and Physiology 2013-06-19T00:00:00Z Native to Central America, the clonal ant Platythyrea punctata has evolved a trait rare among ants: It can produce daughters from unfertilized eggs. What can ants, bees, and other social insects teach us about aging? 2021-03-25T04:00:00Z This finding is consistent with the observation that blood cells in elderly humans are more clonal than those in younger individuals6. Elimination of unfit cells in young and ageing skin 2019-04-02T04:00:00Z The authors introduce the concept of ‘molecular time’ to classify clonal and subclonal mutations. Global genomics project unravels cancer’s complexity at unprecedented scale 2020-02-04T05:00:00Z In some people with clonal hematopoiesis, the offspring of a single mutated stem cell account for more than half of the blood cells in the body. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z This proliferation of T cells is called clonal expansion and is necessary to make the immune response strong enough to effectively control a pathogen. Anatomy and Physiology 2013-06-19T00:00:00Z This lab in New York hopes to Inside the ant lab: Mutants and social genesinvestigate the genetics of ant social behaviour by focussing on an unusual species: the clonal raider ant. Inside the ant lab: Mutants and social genes 2019-03-06T05:00:00Z Further investigation is needed into the possible role of non-cancer-associated gene mutations in the clonal expansion of normal tissues. Mutations differ in normal and cancer cells of the oesophagus 2019-01-01T05:00:00Z Alongside descriptions of clonal forests, underground trees and ‘dancing’ plants, Hallé sets playful stylized drawings explicating the strange behaviours, adaptations and coevolution of each species. Loop quantum gravity redux, ancient automatons, and the weirdness of tropical flora: Books in brief 2018-11-27T05:00:00Z Overall, scientists have found, people with clonal hematopoiesis are up to 50% more likely to die by various ages. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z However, the term clonal selection is not a complete description of the theory, as clonal expansion goes hand in glove with the selection process. Anatomy and Physiology 2013-06-19T00:00:00Z But these six wines speak another truth: There is much variation, thanks to soil type, aspect, clonal selection and heat. ‘The Cab King of Red Mountain’ bottles 6 distinct varieties of cabernet sauvignon for Fidelitas Wines 2018-05-25T04:00:00Z Eguchi, G. & Okada, T. S. Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: a demonstration of a switch of cell types in clonal cell culture. Pancreas regeneration 2018-05-15T04:00:00Z A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Innate immune memory in the brain shapes neurological disease hallmarks 2018-04-10T04:00:00Z Pathologist Siddhartha Jaiswal of the Stanford University School of Medicine and colleagues wondered whether the skewed populations of immune cells in clonal hematopoiesis might also increase the risk of Alzheimer’s disease. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z The adaptive immune response, with its rapid clonal expansion, is well suited to this purpose. Anatomy and Physiology 2013-06-19T00:00:00Z Another factor, Monterro-Serra notes, is that these sessile species are clonal. Why This Animal Can Live for Over 500 Years 2018-03-31T04:00:00Z They propagated vines to sell to neighbors, to friends, to competitors, contributing not only to the availability of exceptional clonal material, but to the reputation of the Rhone plantings across the country. Robert Haas, influential American vintner and wine importer, dies at 90 2018-03-20T04:00:00Z Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation. Dysregulation of expression correlates with rare-allele burden and fitness loss in maize 2018-03-13T04:00:00Z They analyzed brain tissue samples from eight people with clonal hematopoiesis and in six found that unidentified cells carried the same mutations as the blood cell clones. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z For example, using this technique to investigate abnormal cellular growths that eventually progress to a malignant state would be a good choice for future studies into the origin and clonal heterogeneity of tumour cells. On the trail of invasive cells in breast cancer 2018-02-11T05:00:00Z Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary sites1. Asparagine bioavailability governs metastasis in a model of breast cancer 2018-02-06T05:00:00Z The clonal freshwater crayfish is regarded as an invasive species which threatens endemic wild species, but its success may help scientists better understand how cancer spreads. Mutant, all-female crayfish spreading rapidly through Europe can clone itself 2018-02-07T05:00:00Z The bringing together of the two distant slough crayfish enhanced the genetic variation within the new clonal “species.” An aquarium accident may have given this crayfish the DNA to take over the world 2018-02-05T05:00:00Z In two other people with clonal hematopoiesis, they detected the blood mutations in the microglia themselves, finding the telltale changes in between 40% and 80% of the cells. Dangerous blood condition may guard against Alzheimer’s disease 2021-12-13T05:00:00Z They named the condition with medical jargon: clonal hematopoiesis of indeterminate potential, or CHIP. Deadly heart threat found lurking in bone marrow 2018-01-31T05:00:00Z They named the condition with medical jargon: clonal hematopoiesis of indeterminate potential. Scientists Discover a Bone-Deep Risk for Heart Disease 2018-01-29T05:00:00Z But researchers hope that the adaptability of the clonal crayfish may also shed light on how cancer tumours adapt to their environment by developing resistance against drug treatments, for instance. Mutant, all-female crayfish spreading rapidly through Europe can clone itself 2018-02-07T05:00:00Z But “this paper suggests that an animal species can rapidly invade a large geographical area despite reproducing without sex and being clonal,” Danchin says. An aquarium accident may have given this crayfish the DNA to take over the world 2018-02-05T05:00:00Z Becker, A. J., McCulloch, E. A. & Till, J. E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. From haematopoietic stem cells to complex differentiation landscapes 2018-01-23T05:00:00Z Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia 2018-01-16T05:00:00Z Common clonal origin of central and resident memory T cells following skin immunization. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth 2017-11-28T05:00:00Z The team led by Lyko wants to look more closely at how clonal evolution occurs in both marbled crayfish and tumours. Mutant, all-female crayfish spreading rapidly through Europe can clone itself 2018-02-07T05:00:00Z The crayfish’s unusual evolution could also suggest a strategy to tackle a more infamous clonal monster: cancer. An aquarium accident may have given this crayfish the DNA to take over the world 2018-02-05T05:00:00Z The proviral integration pattern was maintained in vivo and epidermal renewal did not cause any clonal selection. Regeneration of the entire human epidermis using transgenic stem cells 2017-11-07T05:00:00Z Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia 2018-01-16T05:00:00Z Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations. The dynamics of molecular evolution over 60,000 generations 2017-10-17T04:00:00Z The clonal raider ants that couldn't sense pheromones acted strangely, too. Normally, these ants detest the smell of Sharpie markers. Scientists create the first mutant ants 2017-08-10T04:00:00Z They capture snapshots of dynamic systems, in which cells are devoid of important context — spatial, temporal, clonal and epigenetic. Immunology, one cell at a time 2017-07-02T04:00:00Z Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. Regeneration of the entire human epidermis using transgenic stem cells 2017-11-07T05:00:00Z Even among younger people, those with the mutations—called clonal hematopoiesis of indeterminate potential, or CHIP—showed a higher rate of heart disease. Researchers Link Cancer Mutations to Heart Disease 2017-06-21T04:00:00Z This file contains a comma-separated list of clonal isolates used in this study. The dynamics of molecular evolution over 60,000 generations 2017-10-17T04:00:00Z It's a clonal tree called "Pando", from the Latin meaning "I spread", and for good reason. The oldest living thing on Earth - BBC News 2017-06-12T04:00:00Z Conservatively, the remaining four samples were also classified as containing clonal haematopoiesis, despite the small number of mutations found in them, and therefore removed from downstream analyses. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z But because these raider ants are clonal, Trible was able to easily test the first offspring for any effects. World’s first genetically modified ants shed light on how complex insect societies evolved 2017-03-08T05:00:00Z Department of Agriculture’s clonal germplasm repository in Davis — a kind of genetic bank and doomsday vault charged with collecting and preserving the nation’s fruit and nut trees. For a budding botanist, the pomegranate is a family tree 2016-12-30T05:00:00Z Their analyses reveal a complex and dynamic evolutionary process of long-term bacterial adaptation in this controlled environment, and include findings on clonal inference, genetic drift and shifting targets of selection. The dynamics of molecular evolution over 60,000 generations 2017-10-17T04:00:00Z Nature doesn’t work in such a methodical manner, and Burnet suggested a messier, more intuitive explanation: the clonal selection theory of immunity. Human Ingenuity Takes On Cancer’s Darwinian Ways 2015-05-18T04:00:00Z Age-related clonal haematopoiesis is quite common, and observed in more than 10% of persons older than 65 years old9, 10, 11. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z "We were astonished to realize that the tumors did not arise from the cells of their diseased host animals, but rather from a rogue clonal cell line spreading over huge geographical distances," Goff said. Contagious Leukemia Killing East Coast Clams 2015-04-09T04:00:00Z Here, the clonal-selection theory, which hypothesized that lymphocytes are diverse and that each is unique, or clonal, was becoming increasingly accepted. Immunology: Fifty years of B lymphocytes 2015-01-05T05:00:00Z The named apples grow as clonal cuttings, fused to hardy rootstocks. Apple Picking Season Is Here. Don't You Want More Than a Macintosh? 2014-10-22T04:00:00Z These findings highlight the difficulties associated with inferring the clonal architecture of cancers from histopathology, even in the ‘simplified’ context of mouse models. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers 2014-04-04T18:28:38.990Z These observations provide a rational strategy to overcome the multifaceted clonal heterogeneity that emerges when tumors are treated with targeted agents. [Research Articles] Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer 2014-02-19T19:26:02.687Z "Our finding of the horizontal transmission of a clonal clam leukemia extends the phenomenon to the marine environment, and demonstrates that this mechanism is more widespread in nature than previously supposed." Contagious Leukemia Killing East Coast Clams 2015-04-09T04:00:00Z Cooper's discovery also set the stage for answering the fundamental question of clonal-selection theory: how is clonal diversity generated? Immunology: Fifty years of B lymphocytes 2015-01-05T05:00:00Z High-throughput T cell receptor sequencing of unmanipulated specimens identified clonal expansions in the tissue that were not readily detectable in peripheral blood. [Research Articles] Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions 2014-01-29T19:55:07.174Z Thus, although distinct clonal configurations evolved, they converged towards analogous malignant phenotypes. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers 2014-04-04T18:28:38.990Z Instead, fitness is following a power-law relationship that is dependent on epistasis and clonal interference. [Report] Long-Term Dynamics of Adaptation in Asexual Populations 2013-12-12T19:26:47.135Z This suggests that knowing the clonal architecture of each patient’s tumour will be crucial for optimizing their treatment. Mutational landscape and significance across 12 major cancer types 2013-10-16T17:22:05.383Z This heterogeneity is later reduced by selected clonal expansion, suggesting that the disseminated cells had yet to acquire key traits of fully malignant cells. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Next-generation sequencing technology allows for the systematic enumeration of single nucleotide mutations and the identification of rare clonal subpopulations that are present in a small fraction of tumour cells. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z Notably, the Wnt models described here provide an experimentally tractable system for exploring whether and how a tumour’s clonal configuration determines its clinical behaviour and curability. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers 2014-04-04T18:28:38.990Z The evolution of the cancer genome may proceed not only in a gradual manner through clonal selection of point mutations or chromosomal alterations, but may also be subject to punctuated phases characterized by drastic changes. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Additionally, the detection and characterization of subclones is also understood to be important for understanding clonal evolution of the cancer and thus patient monitoring and treatment decisions. [Business Office Feature] Unearthing Hidden Genomic Data in Solid Tumor Samples: Are Your FFPE Samples Revealing All? 2013-09-12T17:57:27.597Z Additional layers of diversity are generated by clonal expansion, microevolution and phenotypic plasticity. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Given the complexity of intratumour heterogeneity and clonal evolution, it is impossible to provide approaches that are universally applicable. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z Consistent with this, we did not see evidence of clonal expansions in the patients for up to 20 to 32 months after gene therapy. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z A clonal sweep, whereby a new clone takes over the entire population, replacing ancestral clones, will result in a homogeneous cell population. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Analyses of vector integrations revealed no evidence of aberrant clonal behavior. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy 2013-08-22T18:25:54.897Z M1/PT-like genomes have many and typical copy number alterations, chromosomal breaks, typical point mutations and evidence of clonal expansion. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z The aim of this study is to genomically evaluate all archived tumour samples from a cohort of molecularly profiled patients to assess heterogeneity and clonal evolution. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z Lentiviral gene therapy did not induce selection of integrations near oncogenes, and no aberrant clonal expansion was observed after 20 to 32 months. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z The entire clonal organism, which is said to be derived from a single male plant, contains about 47,000 stems. Olympians of the botanical world 2012-07-31T23:13:09Z Preveiously, the largest clonal size measured was 80 m . . . but so was the largest sample size. MegaGrass Discovered in Mediterranean Marine Meadows 2012-03-02T23:15:00.193Z Additional layers of diversity are generated by clonal expansion, microevolution and phenotypic plasticity. c, Relative stability of M1/PT-like genomes after manifestation of metastasis. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z This type of dynamic examination of clonal evolution is being conducted by programmes such as PREDICT. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z "The age of clonal organisms should therefore be limited as well." Seagrass age surprises scientists 2012-02-02T12:31:11Z The generation of high-depth sequencing data allowed us to quantify accurately mutant allele frequencies in all cases, permitting estimation of the size of tumour clonal populations in each AML sample. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z More importantly, an orthotopic xenograft derived from one of the primary tumours showed no evidence of clonal variation or new coding-region mutations. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z M1/PT-like genomes have many and typical copy number alterations, chromosomal breaks, typical point mutations and evidence of clonal expansion. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Surgical resections of primary tumours or metastatic lesions provide large volumes of tumour tissue that are required for assessment of regional heterogeneity and clonal diversity. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z It all began when comb jellies, sponges and jellyfish, along with clonal bacteria, were the first to group photoreceptive cells and create light-sensitive ‘eyespots’. Evolution: The Rise of Complexity 2012-01-16T21:15:00.253Z Both ALL and AML share common features of clonal heterogeneity at presentation followed by dynamic clonal evolution at relapse, including the addition of new mutations that may be relevant for relapse pathogenesis. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z The second is the ratio of the number of genetically diverse plasma cells to the number of identical, clonal plasma cells in a bone-marrow biopsy. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Now individual cells grew into clonal colonies, each from a single cell. From the shadows to the spotlight to the dustbin - the rise and fall of GFAJ-1 2011-06-16T13:15:02.533Z Last, intratumour heterogeneity and clonal evolution occur and there are feasible technologies to measure these phenomena in the clinical setting. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z Just how that clonal reproduction works, especially on the male side, remains to be explored. Ants Manage Incest Without Inbreeding 2011-02-02T18:02:00Z Regardless, each tumour displayed clear evidence of clonal evolution at relapse and a higher frequency of transversions that were probably induced by DNA damage from chemotherapy. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z One of the more straightforward methods is to measure the tumour burden, or the percentage of clonal plasma cells in the bone marrow. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Through genetic analysis, the Science team was able to confirm that the tumors being spread from devil to devil were the same — genetically identical, exact clonal copies. 2010-01-08T21:15:00Z I intend to cross this clonal group with the following: 1. Northern Nut Growers Association Incorporated 39th Annual Report at Norris, Tenn. September 13-15 1948 Then we are confronted with the problems of seedling versus clonal rootstocks. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 Taken together, these data demonstrate that AML cells routinely acquire a small number of additional mutations at relapse, and suggest that some of these mutations may contribute to clonal selection and chemotherapy resistance. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z A skewed ratio of free kappa to free lambda light chains indicates a proliferation of clonal plasma cells and thus a higher risk of progression. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Just as other seedling fruit trees, such as the orange, apple, peach, almond, etc., have been eliminated, so too, the seedling walnut groves of California seem doomed to be replaced by clonal varieties. Northern Nut Growers Association, report of the proceedings at the sixth annual meeting Rochester, New York, September 1 and 2, 1915 McKAY: I can only tell you about the experiment we started this spring on clonal stocks of chestnuts. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 I do not know whether or not there have been clonal rootstocks selected for Chinese chestnut. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 These data demonstrate that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped, in part, by the chemotherapy that the patients receive to establish and maintain remissions. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z By contrast, he explains, in a person with symptomatic myeloma, nearly all the plasma cells are phenotypically aberrant or clonal. Diagnostics: The early bird 2011-12-14T18:20:59.480Z In other words, we are trying to get a start on a clonal rootstock. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 Eventually, if this thing works, we will establish a clonal line. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 We have hopes that before many years we shall be able to produce parent trees or clonal lines in which the seed taken from those line and planted will give us uniform seedlings. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 We know that even the use of clonal rootstocks does not entirely eliminate variability. Northern Nut Growers Association Report of the Proceedings at the Forty-Second Annual Meeting Urbana, Illinois, August 28, 29 and 30, 1951 |
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