| 单词 | chromosomal |
| 例句 | What I did next had no connection, I believe, with my chromosomal status. Middlesex: A Novel 2002-06-05T00:00:00Z Did every gene have a unique chromosomal “address”? Did genes overlap? The Gene 2016-06-02T00:00:00Z Their obstetrician suspects the baby suffered from chromosomal damage. We Are the Ants 2016-01-19T00:00:00Z Were they strung along chromosomal filaments—like pearls on a string? The Gene 2016-06-02T00:00:00Z Had they been repeatedly domesticated independently, they would exhibit legacies of those multiple origins in the form of varied chromosomal arrangements or varied mutations. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z “So your position is that chromosomal status has been completely overridden by rearing?” Middlesex: A Novel 2002-06-05T00:00:00Z As to which came first, the malignancy or the disturbance of the chromosomes, these workers say without hesitation that “the chromosomal irregularities precede the malignancy.” Silent Spring 1962-09-27T00:00:00Z CONCLUSION: In speech, mannerisms, and dress, the subject manifests a feminine gender identity and role, despite a contrary chromosomal status. Middlesex: A Novel 2002-06-05T00:00:00Z The distinction between the two “races” of flies by virtue of a single chromosomal inversion was the most dramatic example of genetic variation that any geneticist had ever seen in a natural population. The Gene 2016-06-02T00:00:00Z Such cases can often be detected by analyzing the resulting morphological, genetic, or chromosomal differences between specimens of the same crop or domestic animal in different areas. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z In addition to chromosomal and hormonal factors, Luce had to consider my sex of rearing, which had been female. Middlesex: A Novel 2002-06-05T00:00:00Z In contrast, Bill’s reasoning started from the seemingly arbitrary hypothesis that only a fraction of the male chromosomal material enters the female cell. Double Helix 1968-02-27T00:00:00Z Shapiro, a conservative pundit, refuses to call transgender people by their preferred pronouns, claiming that referring to a chromosomally male person as “she” would be “a lie.” The Stylish Socialist Who Is Trying to Save YouTube from Alt-Right Domination 2018-11-20T05:00:00Z Only 2 percent of all women seek a definitive diagnosis of Down syndrome or other chromosomal abnormalities through amniocentesis or chorionic villa sampling during pregnancy. Motherlode Blog: Has Down Syndrome Hurt Us? 2011-10-03T17:10:54Z In half of all miscarriages, the embryo will have a serious chromosomal abnormality that means it could never survive, but the other half are believed to be healthy embryos. My four miscarriages: why is losing a pregnancy so shrouded in mystery? 2020-05-05T04:00:00Z It was clear what kind of answer Blackburn wanted: Something chromosomal. Perspective | Ketanji Brown Jackson did define ‘woman’ at her confirmation hearing 2022-03-25T04:00:00Z Those IVF cycles produced only one embryo that was chromosomally normal. Heal thyself: meet the doctors living with the conditions they treat 2017-02-26T05:00:00Z Pye based Rosie on his daughter, who was born with a chromosomal disorder, and used experiences from his family’s life as inspiration, creating a heartbreaking and compassionate portrait of a modern family. What’s on TV Tuesday: ‘There She Goes’ and ‘Bless This Mess’ 2019-04-16T04:00:00Z The other two authors tell of the horrifying and tragic ordeals of terminating hoped-for pregnancies because of chromosomal abnormalities. The Gift of Donor 8282 2010-05-21T22:52:00Z Older mothers may be more prone to miscarriages, and their babies more in danger of chromosomal disorders, but wealth improves the odds. The agony and ecstasy of becoming an older mother 2015-08-30T04:00:00Z It’s “a mysterious thing that I want,” and it’s also an evolutionary mechanism — “A chromosomal raid/built by what we got built for” — that’s as much a compulsion as a joy. The Playlist: Feist Ponders ‘Pleasure,’ and Frank Ocean Delivers Another Surprise 2017-03-17T04:00:00Z Whether we were pawns of fate or unwitting participants in a chromosomally arranged marriage, Jess and I quickly bonded. First I Met My Children, Then My Girlfriend. They’re Related. 2018-09-28T04:00:00Z Some neuron fired or some chromosomal code activated and I knew, even if I couldn’t articulate it, that I wanted to do whatever I could to experience an event like that again. Mission Impawsible: How Much ‘Cats’ Can a Person Take? 2020-01-21T05:00:00Z The scenario is they introduce chromosomal gene doping through a synthetic virus. `Bourne' writer-director Gilroy taps real science 2012-08-09T16:36:07Z Her chromosomal structure, as a from-the-crypt voice tells us, isn’t so much a matter of the usual x’s and y’s as it is of z’s. | 'Arias With a Twist': ?Arias With a Twist? at Abrons Arts Center - Review 2011-09-19T02:01:03Z After genetic testing, a diagnosis finally arrived: Turner Syndrome, a chromosomal abnormality resulting from a prenatal mutation. 2010-01-29T21:20:00Z The first was a chromosomal test that could be done on the embryo that would cost an additional $3,670. IVF: 'I had the dread feeling that I was part of some greater experiment' 2016-05-06T04:00:00Z I was approaching 35, so the midwife also recommended the quad screening for chromosomal abnormalities. My abortion story 2013-02-06T01:00:00Z And since the risk of chromosomal abnormality increases with age, live birth rates are lower for older eggs. Pentagon Offers Egg-Freezing, But What If Women Are Drafted? 2016-02-04T05:00:00Z These maps placed the election math in starkly chromosomal relief: The male map gave Trump 350 electoral votes to Clinton’s 150. It’s come to this: 2016 is the Rape Election 2016-10-13T04:00:00Z Not in cases of chromosomal aberrations like Down syndrome, he clarified, but in cases where the anomalies were incompatible with life. Perspective | Abortion bans are terrible. The debates over them are actually worse. 2022-09-01T04:00:00Z At least one of our losses was down to a chromosomal abnormality known as a triploidy: essentially an extra set of chromosomes. My four miscarriages: why is losing a pregnancy so shrouded in mystery? 2020-05-05T04:00:00Z I could have gotten an amnio, which at the very least would have told me if my unborn child has any chromosomal deletions or additions. Waiting to love my child 2013-05-07T23:45:00Z The chromosomal lottery had favored a geek dad with an all-star son. Motherlode Blog: The Jock (and his Dad) at the Chess Board 2012-07-29T11:00:43Z Intersex babies are not obviously male or female to begin with, according to society’s general rules about what one’s physical characteristics and chromosomal makeup are supposed to signify. This is What Intersex Means 2014-11-21T05:00:00Z Further testing confirmed the baby had the rare and usually fatal chromosomal disorder known as triploidy — a condition that also can carry serious and sometimes lethal consequences for the mother. Face it, anti-abortion advocates: Pro-choice is pro-life 2015-07-06T04:00:00Z Last month, after fiery debate, South Dakota passed a bill requiring students to use restrooms designated for the gender at birth — to be determined by a chromosomal test or birth certificate. ‘Bathroom panic’ doesn’t help anyone — male, female or transgender 2016-02-26T05:00:00Z She successfully retrieves and fertilizes four eggs from Katkin, testing the embryos to be sure they are chromosomally normal and then implanting them in the surrogate. Two Books Explore the Front Lines of Infertility 2018-07-30T04:00:00Z The key question, she believes, is establishing whether someone is repeatedly losing chromosomally normal or abnormal pregnancies. My four miscarriages: why is losing a pregnancy so shrouded in mystery? 2020-05-05T04:00:00Z Normally, a cell's chromosomes are duplicated before the two identical sets migrate to opposite ends of the cell mitosis in a process called chromosomal segregation. Common chemotherapy drugs don't work like doctors thought, with big implications for drug discovery 2023-10-26T04:00:00Z The chromosomal structure of the Octopus vulgaris genome will also provide insight into the dynamic evolutionary history of these organisms by estimating chromosome rearrangement rates. New insights into the genetics of the common octopus: Genome at the chromosome level decoded 2023-10-18T04:00:00Z Surprisingly, the team said, it also stumbled onto the presence of two genetic "anomalies," called chromosomal inversions. Ruffed grouse population more resilient than expected, genetic study finds 2023-10-04T04:00:00Z "It looks like only chromosomal DNA is deemed 'good enough' to be encased within a fully formed nuclear envelope, and extra-chromosomal DNA is not," Kroschewski says. A hygiene program for chromosomes 2023-10-02T04:00:00Z They then looked at the nuclear DNA, which contains chromosomal information from both parents, and found a mixture of dog and Pampas fox. Meet ‘Dogxim,’ the world’s first known dog-fox hybrid—and a genetic oddity 2023-09-27T04:00:00Z For their study in mice, the researchers focused on 29 genes of this chromosomal region that are also active in the mouse brain. Genetically modifying individual cells in animals 2023-09-20T04:00:00Z Marta Cintas‑Peña, an associate professor of prehistory at the University of Seville, along with her colleagues, detected Ivory Lady's sex using a new technique that identifies chromosomal information in tooth enamel. High-status ancient Spanish tomb held 'Ivory Lady' 2023-07-06T04:00:00Z "We found chromosomal inversions within some of the individuals we sampled, and these were found in individuals from across the Commonwealth," said co-author David Toews, assistant professor of biology at Penn State. Ruffed grouse population more resilient than expected, genetic study finds 2023-10-04T04:00:00Z The DNA transferred can be in the form of a plasmid, a small circular piece of extrachromosomal DNA, or as a hybrid, containing both plasmid and chromosomal DNA. Fundamentals of Biology 2015-01-01T00:00:00Z By observing a karyogram, geneticists can actually visualize the chromosomal composition of an individual to confirm or predict genetic abnormalities in offspring even before birth. Concepts of Biology 2013-04-25T00:00:00Z Before now, it was known that a chromosomal region containing 106 genes is responsible for this disease. Genetically modifying individual cells in animals 2023-09-20T04:00:00Z According to the Centers for Disease Control and Prevention, Down syndrome is the “most common chromosomal condition” diagnosed in the U.S. today. Mattel introduces first Barbie with Down syndrome 2023-04-25T04:00:00Z Toews noted that chromosomal inversions previously were found in other bird species and were expressed via different plumage patterns or more aggressive behaviors, for example. Ruffed grouse population more resilient than expected, genetic study finds 2023-10-04T04:00:00Z The bill also contains exceptions for children experiencing early-onset puberty and those with genetic chromosomal disorders. Doug Burgum signs North Dakota bill banning gender-transition drugs, surgeries for minors 2023-04-20T04:00:00Z More complicated chromosomal sex determining systems also exist. Concepts of Biology 2013-04-25T00:00:00Z Joel has Malan Syndrome, a rare chromosomal condition, and does not have capacity to make any decisions about his finances. Child Trust Funds: Millions of pounds stuck in 80,000 accounts - report 2023-04-19T04:00:00Z According to a new study published in the peer-reviewed journal Nature Immunology, the answer could simply lie in a chromosomal difference. Why do fewer women die of COVID? The answer may lie in the X chromosome's superpower 2023-03-22T04:00:00Z In the meantime, Toews said, the chromosomal inversions have important implications for conservation. Ruffed grouse population more resilient than expected, genetic study finds 2023-10-04T04:00:00Z And the way the technique could open reproduction to couples without an XX-XY chromosomal pair raises a unique question, Cohen said in an e-mail to Scientific American. Mice with Two Fathers? Researchers Develop Egg Cells from Male Mice 2023-03-15T04:00:00Z The sex of an individual may be determined by various chromosomal systems or environmental factors such as temperature. Concepts of Biology 2013-04-25T00:00:00Z Citing data from National Assembly sources, the new report found that nine of those tested — 22.5% — exhibited “worrying levels of chromosomal abnormalities.” Radiation leaks may be hobbling North Korean nuclear ambitions, new report says 2023-02-21T05:00:00Z In those without chromosomal abnormalities, males have XY chromosomes, females have XX. Why do fewer women die of COVID? The answer may lie in the X chromosome's superpower 2023-03-22T04:00:00Z Each is a distinct form within the species — two genetic morphs because of a chromosomal inversion — and possesses different behavioral characteristics. Check your pace and embrace ‘slow birding,’ a contemplative look at our feathered friends 2022-12-29T05:00:00Z These tend to be caused by random chromosomal abnormalities - problems with a foetus's DNA which mean it can't develop properly. Harry and Meghan: What's the link between stress and miscarriage? 2022-12-16T05:00:00Z One form of sympatric speciation can begin with a chromosomal error during meiosis or the formation of a hybrid individual with too many chromosomes. Concepts of Biology 2013-04-25T00:00:00Z The three tests look for the chromosomal abnormalities that cause Down syndrome, Edwards syndrome and Patau syndrome. After changes to California's prenatal testing program, women report long delays for results 2022-12-12T05:00:00Z She was born with a chromosomal abnormality that has affected her ability to have children, she said. Abortion rights take center stage in race between two women vying for Michigan governor 2022-11-07T05:00:00Z Studies have found that 67 percent to 85 percent of women chose termination after diagnoses of Down syndrome, the most common chromosomal abnormality, which results in a range of physical and developmental problems. An Abortion Ban With Unexpected Consequences for Older Mothers 2022-10-07T04:00:00Z Many women, including Ms. Evans, have the embryos tested for chromosomal anomalies. ‘Sobering’ Study Shows Challenges of Egg Freezing 2022-09-23T04:00:00Z Although polyploidy occurs occasionally in animals, most chromosomal abnormalities in animals are lethal; it takes place most commonly in plants. Concepts of Biology 2013-04-25T00:00:00Z There are no recent statistics on the frequency of terminations for fetal anomalies — including genetic or chromosomal abnormalities — in the U.S., but experts say it’s a small percentage of total procedures. They ended wanted pregnancies. Post-Roe, they face new pain. 2022-09-18T04:00:00Z Errors that occur during chromosomal replication are essentially random, which means development can be disrupted in different ways in different embryos. Most human embryos naturally die after conception 2022-09-05T04:00:00Z The cell is accumulating the building blocks of chromosomal DNA and the associated proteins as well as accumulating sufficient energy reserves to complete the task of replicating each chromosome in the nucleus. Biology for AP Courses 2022-06-09T00:00:00Z Guidelines also include a category for a “profound and irremediable congenital or chromosomal anomaly existing in the unborn child that is incompatible with sustaining life after birth.” ‘I’m Carrying This Baby Just to Bury It’: The Struggle to Decode Abortion Laws 2022-08-19T04:00:00Z The number, size, shape, and banding pattern of chromosomes make them easily identifiable in a karyogram and allow for the assessment of many chromosomal abnormalities. Concepts of Biology 2013-04-25T00:00:00Z A screening test for chromosomal abnormalities came back normal and indicated they’d have a girl. They ended wanted pregnancies. Post-Roe, they face new pain. 2022-09-18T04:00:00Z The older a woman is, the more likely that an embryo will have chromosomal abnormalities. New Method Improves Speed and Cost of Birth Defect Testing 2022-08-17T04:00:00Z If a gene is to be transcribed, the histone proteins and DNA are modified surrounding the chromosomal region encoding that gene. Biology for AP Courses 2022-06-09T00:00:00Z There are four types of chromosomal mutations: deletion, duplication, inversion, and translocation. Miller & Levine Biology 2018-01-01T00:00:00Z As many as 30 percent of pregnancies end in miscarriage, the spontaneous demise of a fetus, commonly because of chromosomal abnormalities. Confusion post-Roe spurs delays, denials for some lifesaving pregnancy care 2022-07-16T04:00:00Z The most common cause of trisomy 21 is chromosomal nondisjunction during meiosis. Anatomy and Physiology 2013-06-19T00:00:00Z The complication, a chromosomal abnormality known as Edwards syndrome, generally results in fetal death, or only brief survival for a baby carried to full term. Poland's near-total abortion ban offers a grim glimpse of a possible U.S. future 2022-07-11T04:00:00Z This opens the chromosomal region to allow access for RNA polymerase and other proteins, called transcription factors, to bind to the promoter region, located just upstream of the gene, and initiate transcription. Biology for AP Courses 2022-06-09T00:00:00Z Point mutations change a single base pair, while chromosomal mutations change entire pieces of chromosomes. Miller & Levine Biology 2018-01-01T00:00:00Z Now, a guide for families and caretakers breaks down a new set of advice on caring for the medical needs of adults with the chromosomal abnormality. At last, medical guidelines address care for adults with Down syndrome 2022-07-04T04:00:00Z It was a shock when in her 14th week she learned that doctors suspected her fetus had Edwards syndrome, a serious chromosomal abnormality, and diagnosed other malformations. Poland Shows the Risks for Women When Abortion Is Banned 2022-06-12T04:00:00Z When Sabrina was 5, genetic testing revealed that she had a rare chromosomal deletion associated with autism and developmental delays. Sabrina’s Parents Love Her. But the Meltdowns Are Too Much. 2022-06-01T04:00:00Z One form of sympatric speciation begins with a serious chromosomal error during cell division. Biology for AP Courses 2022-06-09T00:00:00Z Point mutations generally affect one protein, while chromosomal mutations can affect entire gene sequences. Miller & Levine Biology 2018-01-01T00:00:00Z Though it is the most common chromosomal disorder in the United States, affecting about 1 in every 700 babies born, Down syndrome research has historically been underfunded compared with other major genetic conditions. At last, medical guidelines address care for adults with Down syndrome 2022-07-04T04:00:00Z A vast majority of the 144 embryos transferred by the group had only one or two chromosomal abnormalities, but the transfers led to 11 miscarriages in addition to the eight live births. Study raises questions about popular genetic test for ‘abnormal’ embryos 2022-04-20T04:00:00Z Surti and others recognized the unique chromosomal makeup of these cell lines—they only have one parent’s DNA—might make them useful for genomics studies. Most complete human genome yet reveals previously indecipherable DNA 2022-03-30T04:00:00Z The chromosomal basis of inheritance proposed by Mendel provides an understanding of the pattern of passage of genes from parent to offspring. Biology for AP Courses 2022-06-09T00:00:00Z Sports authorities have leaned on medical tests — whether anatomical, chromosomal or hormonal — to determine eligibility in women’s categories, while requiring no analogous tests for men. Trans Swimmer Revives an Old Debate in Elite Sports: What Defines a Woman? 2022-02-16T05:00:00Z Some people blame themselves even though the vast majority of early miscarriages are due to chromosomal abnormalities beyond people’s control. After miscarriages, workers may struggle for needed time off 2022-02-10T05:00:00Z Gleicher said there was “no known connection whatsoever” between the birth defect and the chromosomal error. Study raises questions about popular genetic test for ‘abnormal’ embryos 2022-04-20T04:00:00Z About half of all losses are thought to involve severe chromosomal issues affecting a baby's genetic code, meaning the baby would never have survived. Miscarriage: 'I was in pain and they did not listen' 2022-02-08T05:00:00Z Each parent synthesizes gametes that contain only half of their chromosomal complement. Biology for AP Courses 2022-06-09T00:00:00Z This article uncovers alarming ways in which prenatal testing companies capitalize on fears about chromosomal differences. Opinion | The Benefits and Pitfalls of Prenatal Genetic Tests 2022-01-08T05:00:00Z Va.: I think I am chromosomally incapable of sympathizing with anyone who would bully her way into the delivery room of a woman who has said to her face that she isn’t wanted there. Perspective | Carolyn Hax: Husband won’t tell his mom she can’t be in the delivery room 2021-12-31T05:00:00Z The clinic implanted a round of the couple’s irregular embryos — two embryos with one chromosomal error and one with two errors. Study raises questions about popular genetic test for ‘abnormal’ embryos 2022-04-20T04:00:00Z At that point, genetic testing is done to identify any chromosomal problems or specific genetic mutations. IVF used by some to avoid passing on genetic diseases to offspring 2021-12-03T05:00:00Z One such powerful cytological technique is karyotyping, a method in which traits characterized by chromosomal abnormalities can be identified from a single cell. Biology for AP Courses 2022-06-09T00:00:00Z Most probably because of a chromosomal abnormality, the doctor said. Perspective | Abortion is considered a secret. Women need to tell their stories. 2021-11-26T05:00:00Z The law does not make an exception for pregnant women who learn that the fetus has chromosomal abnormalities or anomalies that will cause the baby to die soon after birth. Texas Abortion Law Complicates Care for Risky Pregnancies 2021-11-26T05:00:00Z First, she wanted to learn how to make the technically precise, rich meals she’d come to love, which made her a chromosomal anomaly in France’s macho teaching kitchens. Review: Feast on the adoring new Julia Child documentary, the tale of a life well-lived 2021-11-11T05:00:00Z Of those babies born with the chromosomal abnormality, the median lifespan is 10-14 days, and only 12% percent survive until age 5. For Texans who have difficult pregnancies, new abortion laws make journey to parenthood harder 2021-11-02T04:00:00Z By observing a karyogram, today’s geneticists can actually visualize the chromosomal composition of an individual to confirm or predict genetic abnormalities in offspring, even before birth. Biology for AP Courses 2022-06-09T00:00:00Z Around 50% of the time it's down to a chromosomal abnormality, where the baby would never have been able to survive, and most women do go on to have a healthy pregnancy. 'I. Am. So. Sorry': Talking about my miscarriages 2021-10-22T04:00:00Z The cancer treatment developer said the FDA ordered a pause to AlloCART-T studies following a report of a chromosomal abnormality in a participant. Occidental Petroleum, Chubb rise; Allogene, Oshkosh fall 2021-10-08T04:00:00Z Historically, infants diagnosed with this chromosomal defect have been aborted or institutionalized; at the time Jon was born, the life expectancy for people with his condition was about 20 years. Review | Woke academics, Donald Trump and George Will’s ire 2021-09-23T04:00:00Z The music floated on the Brothers’ harmonies, in effortless chromosomal alignment and held in place by the crisp playing of Nashville studio veterans. Don Everly, of harmonizing rock 'n' roll pioneers Everly Brothers, dies at 84 2021-08-22T04:00:00Z With increasing age, women are at increased risk of having a baby with a chromosomal abnormality such as Down syndrome. Biology for AP Courses 2022-06-09T00:00:00Z According to the National Down Syndrome Society, about one in every 700 babies in the United States, or roughly 6,000 annually, is born with the condition, which results from a chromosomal irregularity. Down syndrome abortion bans gain traction after court ruling 2021-05-19T04:00:00Z Approximately one in every 700 babies in the United States - or about 6,000 a year - is born with the condition, which results from a chromosomal irregularity, according to the National Down Syndrome Society. N.C. bill banning Down syndrome abortions nears floor vote 2021-05-05T04:00:00Z The different gender was important, allowing Dr. Genden to use chromosomal analysis to detect whether Ms. Sein’s cells populated the new trachea. ‘There Was Nothing Anybody Could Do for These Patients.’ Now There Is. 2021-04-06T04:00:00Z Again and again, biology has proved this not to be the case—chromosomally, hormonally or genetically. It's Time to Take the Penis off Its Pedestal 2021-02-12T05:00:00Z Duplicated chromosomal segments may fuse to existing chromosomes or may be free in the nucleus. Biology for AP Courses 2022-06-09T00:00:00Z It was the first time scientists had found a link between an intellectual disability and a chromosomal anomaly; the condition is now known as trisomy 21. Pope moves Down syndrome MD-advocate closer to sainthood 2021-01-21T05:00:00Z The researchers had already uncovered evidence that having one chromosomal section traced back to Neanderthals could protect against COVID-19 while another, on chromosome 3, could make it worse. Neanderthal gene found in many people may open cells to coronavirus and increase COVID-19 severity 2020-12-18T05:00:00Z A trisomy is a chromosomal condition characterized by an additional chromosome, evident in people living with Down syndrome, Edward syndrome and Patau syndrome. Dem Rep. Jim Cooper clarifies ‘extra chromosomes’ dig at South Carolina voters was about racism 2020-11-24T05:00:00Z People with intellectual disabilities and related conditions include those with Down syndrome and other chromosomal anomalies and congenital conditions like microcephaly. Developmental Disabilities Heighten Risk of Covid Death 2020-11-10T05:00:00Z In transduction, bacteriophages, the viruses that infect bacteria, sometimes also move short pieces of chromosomal DNA from one bacterium to another. Biology for AP Courses 2022-06-09T00:00:00Z During prenatal tests her child was diagnosed with Edwards’ syndrome, which is a chromosomal disease resulting, in most cases, in prenatal death. The price of choice – the fight over abortion in Poland | photo essay 2020-10-23T04:00:00Z Second, viral genomes from controllers are frequently positioned in, or surrounded by, repetitive stretches of DNA at chromosomal structures called centromeres. HIV enters deep sleep in people who naturally control the virus 2020-08-25T04:00:00Z Those who possess a rare chromosomal condition are required to reduce their testosterone levels even lower, to five nanomoles per liter, in races from the quarter mile to the mile. Who Should Compete in Women’s Sports? There Are ‘Two Almost Irreconcilable Positions’ 2020-08-18T04:00:00Z Now, however, a simple blood test, similar to the one used to screen for Down’s syndrome and other chromosomal differences in utero, can reveal single-gene disorders as early as ten weeks into a pregnancy. In utero intervention to stem the damage of cystic fibrosis 2020-07-28T04:00:00Z The DNA transferred can be in the form of a plasmid or as a hybrid, containing both plasmid and chromosomal DNA. Biology for AP Courses 2022-06-09T00:00:00Z Always in the back of researchers’ minds, Sweezey says, is the question: might it be chromosomal? The gender gap in cystic fibrosis 2020-07-28T04:00:00Z The Berger group focuses on epigenetics — chemical modifications to chromosomal DNA and the histone proteins that provide an organizing scaffold for that genetic material. EpiVario: mixing psychotherapy and small-molecule drugs 2020-06-29T04:00:00Z The latest studies, however, looked specifically for large deletions and chromosomal rearrangements near the target site. CRISPR gene editing in human embryos wreaks chromosomal mayhem 2020-06-24T04:00:00Z Towards the end of the nineteenth century, chromosomal abnormalities detected under the light microscope revealed that a type of massive genome instability resulting in an abnormal number of chromosomes occurs in certain types of cancer. Tumour metabolites hinder DNA repair 2020-06-02T04:00:00Z Bacteria can exchange these plasmids with other bacteria, sometimes receiving beneficial new genes that the recipient can add to their chromosomal DNA. Biology for AP Courses 2022-06-09T00:00:00Z This doubling seems to protect the genes needed for the tumour’s survival in the face of the excessive mutations and chromosomal losses that occur in its genome as it develops2. Take lessons from cancer evolution to the clinic 2020-05-26T04:00:00Z Over the years, they narrowed down the gene’s chromosomal location, and in the new research, Kong, now at Shandong Agricultural University, and many colleagues finished the job. How a gene from a grass-living fungus could save wheat crops worldwide 2020-04-09T04:00:00Z Inspired by Brenneman’s personal experiences with her daughter, born with a rare chromosomal abnormality, the actress from “Judging Amy,” “The Leftovers” and “Goliath” works through preconceptions of disability and what is considered “normal.” 'Prelude to a Kiss' musical, Amy Brenneman lead South Coast Repertory 2020-21 season 2020-03-16T04:00:00Z Zernicka-Goetz writes compellingly about her own experiences of a pregnancy in which the fetus was diagnosed through chorionic villus sampling with a risk of severe chromosomal abnormality. From egg to animal: retracing an embryo’s first steps 2020-03-15T04:00:00Z The condensing complex compacts chromosomes, and the resulting condensed structure is necessary for chromosomal segregation during mitosis. Biology for AP Courses 2022-06-09T00:00:00Z One possible explanation for the tumour’s ability to evade the immune system is the chromosomal instability of tumour cells. Take lessons from cancer evolution to the clinic 2020-05-26T04:00:00Z Even after seeing the sonogram, he'd asked to have a diagnostic test done to double check for chromosomal abnormalities. Where science enters the courtroom, the Daubert name looms large 2020-02-23T05:00:00Z The lawsuit seeks to establish a chromosomal standard for girls’ high school sports – that only people with XX chromosomes should be able to compete, Strangio said. The multimillion-dollar Christian group attacking LGBTQ+ rights 2020-02-21T05:00:00Z The risk of a chromosomal abnormality, such as Down syndrome, is 1 in 384 at age 30 but increases to 1 in 66 by age 40. Perspective | We froze our embryos a decade ago when we weren’t ready to be parents. Here’s what happened next. 2020-02-07T05:00:00Z The chromosomal basis of inheritance proposed by Mendel provides an understanding of the pattern of passage of genes from parent to offspring. Biology for AP Courses 2022-06-09T00:00:00Z According to the National Institutes of Health, Trisomy 18 is a chromosomal genetic disorder that includes a combination of birth defects that impact nearly every organ in the body. Birth defects 2nd-leading cause of infant deaths in Indiana 2020-02-02T05:00:00Z But the full chromosomal information held by private services can identify those who share 1% of DNA and are five or more generations removed. DNA genealogical databases are a gold mine for police, but with few rules and little transparency 2019-11-24T05:00:00Z But opponents have argued it would have violated the right of women to make their own decisions about abortion and cautioned against forcing parents to raise children with the genetic chromosomal disorder. Governor vetoes bill outlawing abortions over Down syndrome 2019-11-21T05:00:00Z He was diagnosed with Agenesis of the Corpos Callosum, which affects brain development, and Mosaic Trisomy 9 Syndrome, a rare chromosomal disorder. 'Let the baby die' signs target Ohio family with sick infant: report 2019-11-19T05:00:00Z In fact, it was not until 1900 that his work was rediscovered, reproduced, and revitalized by scientists on the brink of discovering the chromosomal basis of heredity. Biology for AP Courses 2022-06-09T00:00:00Z Large chromosomal segments might even be deleted or rearranged. Got mutation? ‘Base editors’ fix genomes one nucleotide at a time 2019-11-17T05:00:00Z Much like the DNA loops themselves, these insights into the role of chromosomal architecture might help to reveal connections between areas that were previously considered to be separate. One ring to rule them all 2019-10-29T04:00:00Z Furthermore, it might provide a buffer for cancer cells against the detrimental effects on fitness caused by genomic instability, such as damaging mutations and losses of chromosomal segments7. Huge whole-genome study of human metastatic cancers 2019-10-22T04:00:00Z Brain scans, genetic screens and chromosomal analysis failed to pinpoint what was wrong. She began to talk — then mysteriously fell silent. Months later her parents learned why. 2019-10-11T04:00:00Z Explain how chromosomal crossover contributes to genetic diversity. Biology for AP Courses 2022-06-09T00:00:00Z According to the National Down Syndrome Society, about one in every 700 babies in the United States — or about 6,000 a year — is born with the condition, which results from a chromosomal irregularity. Ruling leaves Ohio ban on Down syndrome abortions on hold 2019-10-11T04:00:00Z She has a rare chromosomal abnormality, and her mom says it has been hard for her to find places to socialize since she graduated from high school. Baltimore’s nightclub for disabled adults fosters love, friendship and inclusion 2019-06-04T04:00:00Z These partitioning defects were indicative of an ongoing process of chromosomal instability. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z The bill also includes an exemption in the case that a physician certifies that the "unborn child has a profound and irremediable congenital or chromosomal anomaly that is incompatible with sustaining life after birth." Louisiana governor, a Democrat, poised to sign 'heartbeat' abortion ban into law 2019-05-29T04:00:00Z Diagnostic testing can detect many of these chromosomal disorders in individuals well before birth, resulting in medical, ethical, and civic issues, such as the right to privacy. Biology for AP Courses 2022-06-09T00:00:00Z No one said a woman president was chromosomally ordained to be good, just that those chromosomes shouldn’t keep her from being president. Women hold power in 'Long Shot' and 'Veep' — a fantasy that feels less and less inspiring 2019-05-08T04:00:00Z Still, by comparing chromatin’s properties across different stages of the cell cycle, the team found that chromosomal structure seems to vary strongly with local DNA concentration. The new techniques revealing the varied shapes of chromatin 2019-05-05T04:00:00Z There is much debate about the cause of chromosomal instability in cancer. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z With his family, he created the Hope E. Harrison Foundation to support research into the chromosomal abnormality Trisomy 18, which affects one of his granddaughters. Mark Medoff, Tony-winning playwright of ‘Children of a Lesser God,’ dies at 79 2019-04-24T04:00:00Z Mendel’s laws of inheritance are explained by the chromosomal theory. Biology for AP Courses 2022-06-09T00:00:00Z The fusion of genetics and cytology came in the 1910s, when Thomas Hunt Morgan and his colleagues mapped the chromosomal locations of fruit-fly mutations. The forgotten scientists who paved the way to the double helix 2019-04-15T04:00:00Z The full results, published Thursday in the journal Science, showed that Scott Kelly experienced numerous physiological and chromosomal changes during his long sojourn in orbit, including changes in gene expression. NASA Kelly twins study shows harsh effects of space flight and a brutal return to Earth 2019-04-11T04:00:00Z The low level of chromosomal instability in these tumours probably hindered its detection in earlier bulk DNA-sequencing methods that did not use a single-cell sequencing approach. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z —He experienced some chromosomal instability that might reflect radiation exposure in space. NASA twins study explores space, the final genetic frontier 2019-04-11T04:00:00Z If a gene is to remain turned off, or silenced, the histone proteins and DNA have different modifications that signal a closed chromosomal configuration. Biology for AP Courses 2022-06-09T00:00:00Z ARVs have no impact on that scenario, and the viral DNA ends up at the same chromosomal location in all progeny cells, without acquiring any new mutations. Curing HIV just got more complicated. Can CRISPR help? 2019-03-15T04:00:00Z They found 57 chromosomal locations containing approximately 236 genes that are associated with insomnia symptoms. Insomnia tied to depression, cardiovascular disease 2019-02-25T05:00:00Z There is therefore great interest in gaining a clear picture of chromosomal instability, for example determining the mechanisms responsible, the rate at which such changes occur and how it evolves in a single tumour. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z When cells divide, chromosomal DNA is unwound at replication origins and duplicated by DNA synthesis at dynamic structures called replication forks. Unstable genomes promote inflammation 2019-02-19T05:00:00Z When these modifications occur, the gene present in that chromosomal region is silenced. Biology for AP Courses 2022-06-09T00:00:00Z The CIS samples that regressed generally lacked notable chromosomal aberrations. Genetic clues can be used to predict whether early-stage cancer will form an invasive tumour 2019-02-17T05:00:00Z Although its cause is not precisely known, it's thought it may be caused by chromosomal abnormalities, intrauterine drug exposure or the rupturing of a fetal membrane or yolk sac. Albino baby turtle born with heart outside its body 2019-02-18T05:00:00Z To study chromosomal instability in living cells, Bolhaqueiro et al. isolated samples of human colorectal tumour cells, and cultured the cells directly as organoids. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z As she did so, the clinician asked her if she wanted to tick a box which meant that the placenta DNA would also be tested for other rare chromosomal conditions. 'I nearly aborted my baby because of an unreliable test' 2019-02-07T05:00:00Z A large number of the characteristics that distinguish dogs from cats arose from chromosomal rearrangements that have occurred since both groups diverged from their last common ancestor. Biology for AP Courses 2022-06-09T00:00:00Z Teixeira et al. also observed differences in expression and methylation of genes associated with chromosomal instability, which is characterized by structural alterations such as large insertions or deletions of DNA. Genetic clues can be used to predict whether early-stage cancer will form an invasive tumour 2019-02-17T05:00:00Z The American Academy of Pediatrics and the American College of Medical Genetics and Genomics both recommend certain tests, including chromosomal microarray analysis, a technique that detects large duplications or deletions of DNA. Genetic Tests for Autism Can Sometimes Change Lives 2019-01-31T05:00:00Z Figure 1 | Tracking chromosomal changes in human colorectal cancer. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z Turner syndrome is chromosomal condition that only affects girls. 'I nearly aborted my baby because of an unreliable test' 2019-02-07T05:00:00Z One form of sympatric speciation can begin with a serious chromosomal error during cell division. Biology for AP Courses 2022-06-09T00:00:00Z In some countries, the tests are increasingly being used to look for large chromosomal abnormalities, such as the extra copy of chromosome 21 that causes Down’s syndrome. Prospective parents should be prepared for a surge in genetic data 2019-01-28T05:00:00Z Maia’s condition is one of only a few associated with autism that are caused by large chromosomal mutations. Genetic Tests for Autism Can Sometimes Change Lives 2019-01-31T05:00:00Z The emergence of chromosomal abnormalities in colorectal cancer is associated with poor prognosis, and understanding how such changes occur in living cells might reveal targets for drug development. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z It's mainly used to screen for Down's Syndrome and two other chromosomal anomalies, Edwards Syndrome and Patau Syndrome. 'I nearly aborted my baby because of an unreliable test' 2019-02-07T05:00:00Z Plasmids, which consist of extra- chromosomal DNA, are also present in many species of bacteria and archaea. Biology for AP Courses 2022-06-09T00:00:00Z Makenna was born Nov. 12 with Trisomy 13, a chromosomal condition that affected her heart. Brandon Mebane back with the Chargers after death of infant daughter 2019-01-09T05:00:00Z The authors detected few chromosomal alterations in normal samples and confirmed the high level of chromosomal instability in OSCC. Mutations differ in normal and cancer cells of the oesophagus 2019-01-01T05:00:00Z Finally, aneuploidy is emerging as a possible early event driving tumour evolution12,13, but information about the frequency and types of chromosomal instability during the initial stages of tumour evolution is extremely limited. Watching cancer cells evolve through chromosomal instability 2019-06-02T04:00:00Z There are many reasons, including behavioural problems that affect teeth brushing, gastric reflux, and some chromosomal disorders. Woman died after all teeth removed 2018-12-13T05:00:00Z Several classes of protein are involved in the organization and packing of the chromosomal DNA into a highly condensed structure. Biology for AP Courses 2022-06-09T00:00:00Z Severe genetic problems such as single‑gene or chromosomal problems or severe environmental problems such as neglect or abuse can have devastating effects on children’s cognitive and emotional development. Why DNA may matter more than parenting — and what that means for society 2018-11-23T05:00:00Z Scientists now have an understanding of bee health down to the chromosomal level, enabling them, for example, to analyse precisely how pathogens and parasites affect their bee hosts. Invasion of the ‘frankenbees’: the danger of building a better bee 2018-10-16T04:00:00Z The result was an increase in chromosomal abnormalities in the lab animals and their offspring. BPA substitutes may be just as bad as the popular consumer plastic 2018-09-13T04:00:00Z In the future, reducing the chromosome number through a variety of fusion paths might reveal how chromosomal structures affect cell viability. Yeast chromosome numbers minimized using genome editing 2018-07-31T04:00:00Z The chromosomal basis of inheritance proposed by Mendel provides an understanding of the pattern of passage of genes from parent to offspring. Biology for AP Courses 2022-06-09T00:00:00Z There She Goes will be based on the experiences of Pye, whose daughter was born in 2006 with a rare and undiagnosed chromosomal disorder. Tennant to star in disability comedy show 2018-06-19T04:00:00Z We live in exciting times, and that includes novel insights into the sole chromosomal distinction between you and the women now prowling the aisles at the hardware store. Secrets of the Y Chromosome 2018-06-11T04:00:00Z For instance, duplications within the chromosomal region 1q21 are associated with autism and macrocephaly, while deletions are linked to schizophrenia and microcephaly. Scientists are untangling our bodies’ genetic “double-edged swords” 2018-06-09T04:00:00Z Ninety-five percent of babies with the chromosomal disorder die in utero. How an Irish-American woman’s legal case helped spur Ireland’s abortion referendum 2018-05-16T04:00:00Z Therefore, genes that are far apart on the same chromosome are likely to still assort independently because of recombination events that occurred in the intervening chromosomal space. Biology for AP Courses 2022-06-09T00:00:00Z The results showed that genes for flower quality, such as recurrent flowering, are located on chromosomal segments transmitted to modern roses from Chinese roses imported to Europe in the eighteenth century. DNA uncovers the source of a rose’s bloom 2018-04-29T04:00:00Z That unfortunate act of chromosomal decluttering appears to put the men at a heightened risk of Alzheimer’s disease, leukemia and other disorders. Secrets of the Y Chromosome 2018-06-11T04:00:00Z It’s not just that they are male – anatomically so, chromosomally so – but that they see themselves as men. Almost all violent extremists share one thing: their gender 2018-04-08T04:00:00Z Her team studies chromosomal replication and repair to better understand the causes of cancer. Why Aren't There More Women Leaders in Science? 2018-04-02T04:00:00Z The chromosomal basis of inheritance proposed by Mendel provides an understanding of the pattern of passage of genes from parent to offspring. Biology for AP Courses 2022-06-09T00:00:00Z The researchers then screened the DNA for known chromosomal abnormalities and genetic mutations linked to gynaecological cancers. Souped-up screening test finds three types of cancer instead of one 2018-03-21T04:00:00Z Lacking the standard repair system of chromosomal recombination, genes on the Y chromosome began to decay and were eventually tossed out or reassigned to other chromosomes. Secrets of the Y Chromosome 2018-06-11T04:00:00Z It’s lousy with them, though we chromosomally dyspeptic pundits prefer to shake our heads and sigh. Opinion | Democrats Are Primed for 2018 and Looking Pretty in 2020 2018-03-17T04:00:00Z This is a congenital condition resulting from a chromosomal abnormality. Opinion | The real Down syndrome problem: Accepting genocide 2018-03-14T04:00:00Z The chromosomal basis of inheritance proposed by Mendel provides an understanding of the pattern of passage of genes from parent to offspring. Biology for AP Courses 2022-06-09T00:00:00Z Hannah was born with spina bifida and mosaic trisomy 13, a chromosomal disorder. Teen’s dying wish fulfilled by Make-a-Wish Foundation 2018-03-06T05:00:00Z In the past, women had to undergo chorionic villus sampling, in which cells are taken from the placenta, or amniocentesis, which involves removing fluid from the womb, to test for the chromosomal abnormality. Babies with Down syndrome are put on center stage in the U.S. abortion fight 2018-03-05T05:00:00Z Babies born with omphaloceles are prone to heart, lung and chromosomal defects, the latter of which is more greatly associated with small omphaloceles. Minnesota couple raises awareness for unborn child’s defect 2018-02-03T05:00:00Z Genetic suppression of chromosomal instability markedly delays metastasis even in highly aneuploid tumour models, whereas continuous chromosome segregation errors promote cellular invasion and metastasis in a STING-dependent manner. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z Chromosome disorders can be divided into two categories: abnormalities in chromosome number and chromosomal structural rearrangements. Biology for AP Courses 2022-06-09T00:00:00Z If the bill is enacted, Ohio would become the latest state to try to stop women from aborting fetuses when they discover through prenatal testing that they have a chromosomal defect. Ohio moves closer to banning abortions when fetuses have Down syndrome 2017-12-14T05:00:00Z The debate about abortion has become intertwined with Down syndrome in recent years because of the availability of a noninvasive test that can screen for Trisomy 21 — the chromosomal defect that leads to the condition. Babies with Down syndrome are put on center stage in the U.S. abortion fight 2018-03-05T05:00:00Z Recent chromosomal blood test results were normal, as was a fetal electrocardiogram. Minnesota couple raises awareness for unborn child’s defect 2018-02-03T05:00:00Z By subverting lethal epithelial responses to cytosolic DNA, chromosomally unstable tumour cells co-opt chronic activation of innate immune pathways to spread to distant organs. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. Biology for AP Courses 2022-06-09T00:00:00Z Nasmyth’s prize is for figuring out how the DNA packed into cells is faithfully replicated and separated when cells divide into two—which is crucial for preventing such problems as cancer and chromosomal abnormalities. Cutting-Edge Science Honored by Star-Studded Breakthrough Prize Awards 2017-12-03T05:00:00Z An improved assembly and annotation of the allohexaploid wheat genome identifies complete families of agronomic genes and provides genomic evidence for chromosomal translocations. Genome sequence of the progenitor of the wheat D genome Aegilops tauschii 2017-11-14T05:00:00Z Dekker, J. & Mirny, L. The 3D genome as moderator of chromosomal communication. Two independent modes of chromatin organization revealed by cohesin removal 2017-09-26T04:00:00Z Thompson, S. L. & Compton, D. A. Examining the link between chromosomal instability and aneuploidy in human cells. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z The girl had lain in a coma for months, after a string of complications from a rare chromosomal disorder. Becoming a Steelworker Liberated Her. Then Her Job Moved to Mexico. 2017-10-14T04:00:00Z Yes, the cell-free DNA test can see chromosomal problems earlier, but insurance only covers that if you're considered high risk. Opinion | Sex, Sanctimony and Congress 2017-10-05T04:00:00Z That research uncovered the chromosomal nature of the gene, the mutagenic nature of radiation, the molecular blueprint that underpins animal bodies and core secrets of the immune defense system. Opinion | Another Nobel Prize for the Fruit Fly 2017-10-04T04:00:00Z Nora, E. P., Dekker, J. & Heard, E. Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods? Two independent modes of chromatin organization revealed by cohesin removal 2017-09-26T04:00:00Z Numerical chromosomal instability mediates susceptibility to radiation treatment. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z A surprising number control the structure of chromosomal DNA and so increase or decrease the activity of genes across the genome. Genetics: Sex and the single cell : Nature : Nature Research 2017-10-03T04:00:00Z According to the National Down Syndrome Society, about one in every 700 babies in the United States - or about 6,000 a year - is born with the condition, which results from a chromosomal irregularity. Should states ban abortions when Down syndrome diagnosed? 2017-09-24T04:00:00Z Juicebox is just one of a range of freely available programs for exploring 2D interaction data: some focus on relatively narrow chromosomal loci, whereas others enable genome exploration. Plot a course through the genome 2017-09-04T04:00:00Z Here we show that deletion of the cohesin-loading factor Nipbl in mouse liver leads to a marked reorganization of chromosomal folding. Two independent modes of chromatin organization revealed by cohesin removal 2017-09-26T04:00:00Z Replication stress links structural and numerical cancer chromosomal instability. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z The little girl had a chromosomal disorder and her range of motion was limited so using a wheelchair would be a necessity. ‘Would you kill my mother for me?’: a dark case of abuse and revenge 2017-08-27T04:00:00Z As both treated and control ES cells showed this chromosomal rearrangement, we reasoned that it was contributed by the sperm and could be inherited. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z The vast majority of deaths occur in the first weeks of life and are tied to chromosomal abnormalities or deformations or complications related to pregnancy. Baby boxes proposed in D.C. as wave of states look to Finland to prevent infant deaths 2017-07-27T04:00:00Z Infant deaths largely occurred in the first weeks of life and were tied to chromosomal abnormalities or deformations or complications related to pregnancy. Child death rate declines in the District, report says 2017-07-20T04:00:00Z Sheltzer, J. M. A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z Clinicians routinely screen the chromosomes of a developing baby to identify large chromosomal abnormalities, including CNVs. Is there such a thing as an autism gene? 2017-06-30T04:00:00Z "While the effect of female age on fertility is overwhelmingly due to increased rates of chromosomal abnormality, the proposed mechanism in the effect of male age on pregnancy are more subtle." Older male partners 'lower chances of IVF baby success' - BBC News 2017-07-02T04:00:00Z In some ways, the implications of the many chromosomal changes suggested by the new analysis is obvious—just look how different an ant-eater is from a whale. Digital reconstruction of ancient chromosomes reveals surprises about mammalian evolution 2017-06-19T04:00:00Z Moreover, chromosomal compartments are differentiated by an exponential gradient of gene density and recombination rate, striking contrasts in the distribution of retrotransposon families, and distinct patterns of genetic diversity. A chromosome conformation capture ordered sequence of the barley genome : Nature : Nature Research 2017-04-25T04:00:00Z Although it is known that gross chromosomal abnormalities are remarkably common in early human embryos6, our understanding of early embryonic somatic mutations is very limited. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z To test the effect of the increasing number of driver mutations and chromosomal instability on tumour growth in vivo, we subcutaneously transplanted organoids from each genotype in mice and followed their progression longitudinally. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer : Nature : Nature Research 2017-03-28T04:00:00Z Graduate students and postdoctoral associates will then lead small groups of students in activities including DNA extraction and karyotyping for chromosomal differences. 400 Buffalo students to explore STEM on medical campus 2017-03-09T05:00:00Z A subsequent MRI raised even more worries, suggesting that they were confronting trisomy 13, a chromosomal condition involving devastating physical abnormalities. A mysterious medical condition gets a name — and a genetic link to deafness 2017-03-05T05:00:00Z So if your fetus was sick, or had a disability or chromosomal abnormality, your doctor could literally not tell you – and that would be legal. The week in patriarchy: Texas doctors fight for right to lie to pregnant women | Jessica Valenti 2017-03-03T05:00:00Z Meshing Blackburn's work on telomeres — the chromosomal 'caps' that are biological indicators of life experience — with Epel's research on stress, the volume outlines a regime designed to boost telomerase, the enzyme that replenishes telomeres. Books in brief : Nature : Nature Research 2017-02-14T05:00:00Z Doctors there identified the cause of her developmental delays: DiGeorge syndrome, a chromosomal disorder. Dreams That a Sister Can Have the ‘Fullest’ Life Possible 2016-12-11T05:00:00Z Down syndrome, a chromosomal condition, carries physical traits including flat facial features, a small nose and an upward slant to the eyes. Ads with Down syndrome models reflect millennials’ ideal of inclusiveness 2016-12-01T05:00:00Z Tuttle leaves a rich research legacy that raises further questions, including whether this chromosomal system is ultimately destined to disappear. The sparrow with four sexes 2016-11-22T05:00:00Z Note that the chromosomal locations of these genes on the proto-XTR10 differ between the two models. Genome evolution in the allotetraploid frog Xenopus laevis : Nature : Nature Research 2016-10-18T04:00:00Z Along with chromosomal abnormalities, structural problems with the uterus could lead to repeated lost pregnancies, Bronson says. You Asked: What Causes a Miscarriage? 2016-10-19T04:00:00Z What isn't mentioned here is any type of chromosomal testing done prior to embryo transfer. The Misleading Promise of I.V.F. for Women Over 40 2016-10-17T04:00:00Z Eight chromosomal arms are spanned by single scaffolds. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z A chromosomal inversion this large was rare in vertebrates, Thorneycraft noted. The sparrow with four sexes 2016-11-22T05:00:00Z Black arrows indicate the direction of chromosomal evolution. Genome evolution in the allotetraploid frog Xenopus laevis : Nature : Nature Research 2016-10-18T04:00:00Z The risk for chromosomal abnormalities goes up as a woman ages. You Asked: What Causes a Miscarriage? 2016-10-19T04:00:00Z If you could place 1 chromosomally complete embryo or 6 wild cards, what would you do? The Misleading Promise of I.V.F. for Women Over 40 2016-10-17T04:00:00Z Eight chromosomal arms are spanned by single scaffolds. De novo assembly and phasing of a Korean human genome : Nature : Nature Research 2016-10-04T04:00:00Z In his research, he determined the chromosomal locations for more than a dozen other diseases, including Parkinson’s, Lou Gehrig’s and muscular dystrophy. Allen Roses, Who Upset Common Wisdom on Cause of Alzheimer’s, Dies at 73 2016-10-05T04:00:00Z Note that the chromosomal locations of these genes on the proto-XTR10 differ between the two models. Genome evolution in the allotetraploid frog Xenopus laevis : Nature : Nature Research 2016-10-18T04:00:00Z Jeve says the majority of sporadic miscarriages are attributable to unpreventable “chromosomal abnormalities.” You Asked: What Causes a Miscarriage? 2016-10-19T04:00:00Z Yet, untested fresh and frozen embryos are assessed only visually, and you can't assess chromosomal abnormality that way. The Misleading Promise of I.V.F. for Women Over 40 2016-10-17T04:00:00Z Otherwise, older eggs pose a higher risk of chromosomal abnormalities, namely trisomy 21 or Down syndrome, Paulson says. Navigating a Safe Pregnancy in Your 40s 2016-10-04T04:00:00Z Clinicians currently rely on checks for chromosomal abnormalities and analysis under a microscope. Study says a major blood cancer is 11 distinct diseases - BBC News 2016-06-08T04:00:00Z Black arrows indicate the direction of chromosomal evolution. Genome evolution in the allotetraploid frog Xenopus laevis : Nature : Nature Research 2016-10-18T04:00:00Z Such sex-reversed lizards still retain the chromosomal makeup of a male, but they develop into functional superfemales, whose output of eggs exceeds that of the regular females. ‘Third sex’ lizards could outcompete their normal female cousins 2016-06-07T04:00:00Z “Obviously, advantages are not only increasing the chance of a success, but diminishing the chances of miscarriages, because most miscarriages are due to chromosomal abnormalities during the first trimester.” Turning to technology when nature isn’t enough for pregnancy 2016-04-09T04:00:00Z "The whole pregnancy was completely normal," she recalls, adding that she was automatically referred to a perinatologist, a specialist in high-risk pregnancies, and also underwent amniocentesis to test for chromosomal abnormalities in the fetus. Navigating a Safe Pregnancy in Your 40s 2016-10-04T04:00:00Z Down syndrome affects about 400,000 families in the United States; it’s the most common form of chromosomal disorder, showing in about one out of every 700 babies. Most people saw limits for this boy with Down syndrome. His parents saw potential. 2016-03-02T05:00:00Z The Fan1 nuclease protects stalled DNA replication forks and thereby prevents chromosomal damage and cancer. Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability | Science 2016-02-18T05:00:00Z In cases when women have one or two miscarriages, the cause is usually severe chromosomal problems, experts say. Miscarriages reported in 2 U.S. women with Zika virus, CDC says 2016-02-11T05:00:00Z Another process, pre-implantation genetic screening, analyzes embryos that are a few days old to determine whether there are chromosomal abnormalities before they’re implanted. Turning to technology when nature isn’t enough for pregnancy 2016-04-09T04:00:00Z Charlton's team excluded any infants with defects caused by known factors, such as fetal alcohol syndrome or chromosomal abnormalities. No Link Between 'the Pill' and Birth Defects: Study 2016-01-06T05:00:00Z Miscarriage is often caused by chromosomal errors that happen by chance. Progesterone May Not Help Women With History of Miscarriages, Study Finds 2015-11-25T05:00:00Z The Fan1 nuclease protects stalled DNA replication forks and thereby prevents chromosomal damage and cancer. Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability | Science 2016-02-18T05:00:00Z Schira was born with Turner syndrome, a somewhat rare chromosomal condition in girls that affects physical development. Blind teacher challenges Wahlert students 2015-11-21T05:00:00Z "Until now, colistin resistance resulted from chromosomal mutations, making the resistance mechanism unstable and incapable of spreading to other bacteria." Scientists Spot Gene That Could Make Bacteria Resistant to All Antibiotics 2015-11-18T05:00:00Z All six full-term pregnancies that followed resulted in chromosomally normal infants, the researchers reported. Controversial Fertility Treatment Resulted in Live Births 2015-11-18T05:00:00Z The group is expanding the study to include about 20 chromosomal regions commonly altered in invasive breast cancer. Molecular biology: Marked progress : Nature : Nature Publishing Group 2015-11-17T05:00:00Z Separately, each test was able to track potential genetic causes of autism about equally -- about 9 percent for chromosomal microarray analysis and more than 8 percent for whole-exome sequencing. Cutting-Edge Genetic Tests May Improve Management of Autism 2015-09-01T04:00:00Z Then, the chromosomal test should be done to see if it yields any additional information about a connection to autism. Researchers Zero In On Best Way to Diagnose Autism 2015-09-01T04:00:00Z The leading cause of death in 2013 was congenital malformations, deformations and chromosomal abnormalities. U.S. Infant Mortality Rates Drop Slightly 2015-08-06T04:00:00Z Between 10 percent and 20 percent of a woman's eggs might be chromosomally abnormal in her mid-20s. Controversial Fertility Treatment Resulted in Live Births 2015-11-18T05:00:00Z At 16 weeks we learned our little girl had Turner's Syndrome, a rare chromosomal anomaly affecting only females. Stillbirth: Your Stories 2015-06-26T04:00:00Z For those who are otherwise healthy but are of advanced maternal age – 35 and up – it's important to consider potential chromosomal abnormalities in the baby, Szymanski says. When Your Pregnancy Is High Risk 2015-07-21T04:00:00Z Cholesterol, blood pressure, dental status, eye structure and heart health were also assessed, as was the length of chromosomal caps known as telomeres. Some People Do Age Faster Than Others 2015-07-06T04:00:00Z The same test that screens for chromosomal disorders like Down syndrome may also identify early stage cancers in expectant mothers. DNA Test Detects Cancer During Pregnancy 2015-06-08T04:00:00Z Researchers from European Hospital in Rome detected chromosomal mosaicism in nearly 5 percent of about 3,800 embryos included in the study. Controversial Fertility Treatment Resulted in Live Births 2015-11-18T05:00:00Z At 16 weeks we learned our little girl had Turner's Syndrome, a rare chromosomal anomaly affecting only females. Stillbirth: Your Stories 2015-06-26T04:00:00Z The couple co-wrote a raw and revealing book, “Bella’s Gift,” this year about the chromosomal condition Trisomy 18, which is rare and lethal. Rick Santorum announces second presidential bid 2015-05-27T04:00:00Z Dominique was born with a rare chromosomal disorder called Phelan-McDermid Syndrome. Las Cruces family seeks return of girl’s custom stroller 2015-05-17T04:00:00Z His team experimented on 86 one-cell human embryos, they reported, all from fertility clinics and, because of chromosomal defects, unable to develop into a baby. First experiment 'editing' human embryos ignites ethical furor 2015-04-23T04:00:00Z Ariosa Diagnostics, acquired by Roche in January, says its Harmony test for fetal chromosomal abnormalities offers "clear answers to questions that matter," promising "accurate results from as early as 10 weeks of pregnancy." Fetal DNA tests prove highly accurate but experts warn of exceptions 2015-04-01T04:00:00Z The blood test looks for patterns of various substances in a mother's blood that are associated with chromosomal problems that lead to Down syndrome, while the ultrasound examines the fetus for indications of birth defects. Newer Test for Down Syndrome Called 'Major Advance' 2015-04-01T04:00:00Z However, the reviewers said, there is evidence of chromosomal damage in studies involving animal and human cells. Decades After Monsanto’s Roundup Gets an All-Clear, a Cancer Agency Raises Concerns 2015-03-27T04:00:00Z For example, about half of a 30-year-old woman’s eggs are chromosomally normal but by age 44 this figure drops to 2 percent, according to Grifo. Elective Human Egg Freezing on the Rise 2015-02-18T05:00:00Z Conditions such as these meet the medical definition of DSDs, in which an individual's anatomical sex seems to be at odds with their chromosomal or gonadal sex. Sex redefined 2015-02-17T05:00:00Z The kids haven’t been tracked over the long term, and it’s unknown whether the procedure contributed to two cases of chromosomal abnormalities that resulted in one miscarriage and one abortion. Three-Parent IVF Deserves a Chance in the U.S. 2015-02-03T05:00:00Z "What the mother and fathers of these children have in common" is that they all have a child with a chromosomal abnormality. ‘Food Is a Death Sentence to These Kids’ 2015-01-21T05:00:00Z Telomeres are stretches of DNA that cap our chromosomes and help prevent chromosomal deterioration -- biology professors often liken them to the plastic tips on shoelaces. Changing Our DNA Through Mind Control? 2014-12-16T05:00:00Z This is key, particularly for hopeful older mothers: only 2 in 5 of a young woman’s eggs are chromosomally normal, and that figure decreases with age. Twins: The Fetal Paradox Furthermore, accelerated rearrangement was confined to large-scale chromosomal events, pointing to a mechanism responsible for causing gross chromosomal changes, rather than global genomic instability. Gibbon genome and the fast karyotype evolution of small apes : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Higher levels of BPA were linked to stunted human oocytes, as well as indications of chromosomal damage – a finding also found in animals studied by Dr. Hunt. In Plastics and Cans, a Threat to Women 2014-08-28T04:00:00Z The diagnosis was a rare chromosomal abnormality called Prader-Willi syndrome, which causes low muscle tone and impairs signaling between the brain and the stomach. ‘Food Is a Death Sentence to These Kids’ 2015-01-21T05:00:00Z Heterochromatin is a classically defined and distinct chromosomal domain with important roles in genome organization, genome stability, chromosome inheritance and gene regulation. Comparative analysis of metazoan chromatin organization : Nature : Nature Publishing Group 2014-08-26T04:00:00Z Some clinics biopsy the embryos to find the chromosomally normal ones. Twins: The Fetal Paradox Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Gibbon genome and the fast karyotype evolution of small apes : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Roughly half of the children born with the genetic, chromosomal disorder suffer from heart defects. Texas man knows how to jam, while helping others 2014-08-20T04:00:00Z Eckhardt admitted in his blog comment that the Down's diagnosis is not certain because there's no way to confirm the Hobbit's chromosomal makeup. Strong words over a 'Hobbit' : Nature : Nature Publishing Group 2014-08-19T04:00:00Z Seven years ago, major medical groups urged that all women be offered screening and diagnostic tests for the syndrome - not just those over 35, when the risk of chromosomal abnormalities rises. Pa. law mandates information on Down syndrome 2014-08-20T04:00:00Z “I was at work when I got the phone call telling me about the abnormal chromosomal depletion. It was one of our hardest days,” Ashley Jones said, recalling the conversation with the doctor. Ala. family faces unknown after girl’s diagnosis 2014-07-22T04:00:00Z For some women, they say, chromosomal testing, an invasive procedure, might even worsen their chances of getting pregnant. Fertility Clinics Scan for the Strongest Embryo 2014-07-11T04:00:00Z Two embryos with Turner syndrome, typically a rare chromosomal abnormality, occurred after the procedure; one miscarried, the other was aborted. The Brave New World of Three-Parent I.V.F. 2014-06-27T04:00:00Z The researchers first examined the children's cheek cell samples for abnormal chromosome numbers, as well as other chromosomal defects. Scientists See Environmental Changes to Genes in Kids With Autism 2014-05-29T04:00:00Z She had an abortion in 2011 after finding out her child had a chromosomal defect. Missouri governor concerned about abortion bill 2014-05-15T04:00:00Z To the medical community at Maryland’s National Institutes of Health, Tyley Sue Jones, the only person in the world known to suffer from a specific chromosomal defect, represents a rare specimen. Ala. family faces unknown after girl’s diagnosis 2014-07-22T04:00:00Z With the chromosomal screening, the goal is mainly to improve birthrates, not influence the traits of the baby. Fertility Clinics Scan for the Strongest Embryo 2014-07-11T04:00:00Z Here’s how it works: Although a woman undergoing IVF might produce enough eggs to create a half-dozen embryos, only a certain percentage will be chromosomally normal and likely to lead to a pregnancy. The Problem With America’s Twin Epidemic 2014-04-16T09:45:10Z In the 1970s, the discovery of chromosomal abnormalities and cancer-causing mutations shifted focus to the disease’s genetic origins. Metabolic quirks yield tumour hope 2014-04-09T17:20:17.678Z He told the BBC: "The mutations in this gene result in damage to the end of the chromosomes and chromosomal damage in general is linked to cancer formation - that's the pathway for it." 'Step forward' in skin cancer fight 2014-03-30T17:01:05Z Since transfer-RNA genes are often sites of chromosomal instability, excising a few of them seemed to the team like a good idea. Synthetic biology: DIY chromosomes 2014-03-27T15:58:21Z The court was told Medcalf's chromosomal disorder, which also leaves him with adolescent emotions, was diagnosed last year. Criminal freed as jail bed too small 2014-03-26T19:56:39Z These results delineate chromosomal instability as a mechanism of modulating local cytokine expression in human tumors and underline the major role of IL15. [Research Articles] Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients 2014-03-19T18:25:07.417Z Cytogenetic analysis revealed additional genetic alterations such as chromosomal translocations. [Research Articles] Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity 2014-03-12T18:25:14.471Z The study, which was funded by Illumina, screened more than 1,900 US women for chromosomal abnormalities, including Down’s syndrome, using both the biochemical and genetic methods. Prenatal-screening companies expand scope of DNA tests 2014-03-05T18:50:33.037Z Born with a rare chromosomal disorder, 6-year-old Lydia suffers from life-threatening seizures that doctors haven’t been able to control despite countless medications. ‘Mommy lobby’ emerges as a powerful advocate for medical marijuana for children 2014-03-03T02:01:00Z The other five chromosomally abnormal babies were born alive. Well: New DNA Test Better at Predicting Some Disorders in Babies, Study Finds 2014-02-26T22:03:51Z The team led by Dr. Myers has developed a statistical technique for identifying the chromosomal segments with particular precision. Tracing Ancestry, Team Produces Genetic Atlas of Human Mixing Events 2014-02-13T19:17:06Z The chromosomal nomenclature follows a previous study describing a Beta karyotype at chromosome arm resolution. The genome of the recently domesticated crop plant sugar beet (Beta vulgaris) 2014-01-22T18:21:48.441Z This is a huge advance over amniocentesis, the common—and risky—test for fetal chromosomal abnormalities that involves sticking a needle into the mother’s uterus. Illumina's New Low-Cost Genome Machine Will Change Health Care Forever 2014-01-15T20:58:23Z The director of the laboratory that offered her space was an authority on leukemia, and Dr. Rowley began hunting for chromosomal anomalies in genetic samples from his patients. Janet D. Rowley, Who Discovered That Cancer Can Be Genetic, Dies at 88 2013-12-21T02:55:29Z But a negative result would provide confidence that these two major chromosomal disorders are absent. Well: New DNA Test Better at Predicting Some Disorders in Babies, Study Finds 2014-02-26T22:03:51Z A scientist in pediatrics and developmental biology at the University of Massachusetts Medical School, Lawrence studies chromosomal disorders. Hope Seen In Chromosome Therapy For Down Syndrome 2013-11-10T18:47:00Z This progressive loss eventually causes the telomeres to lose their ability to protect the ends of chromosomal DNA. The Hallmarks of Cancer: 4 - Limitless Replicative Potential 2013-10-10T19:45:47.683Z They’re both articulate and earnest and share the fanatical attention to detail that Jobs instilled in Apple at a chromosomal level. Apple Chiefs Discuss Strategy, Market Share—and the New IPhones 2013-09-19T09:44:48Z Because Down syndrome was known to be caused by a chromosomal abnormality, she chose to spend her year there studying new methods of chromosome analysis. Janet D. Rowley, Who Discovered That Cancer Can Be Genetic, Dies at 88 2013-12-21T02:55:29Z The women received standard screening from their doctors, a blood test that identifies proteins or other biological markers associated with chromosomal disorders. Well: New DNA Test Better at Predicting Some Disorders in Babies, Study Finds 2014-02-26T22:03:51Z M1/PT-like genomes have many and typical copy number alterations, chromosomal breaks, typical point mutations and evidence of clonal expansion. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Defects in DSB detection or repair result in chromosomal instability, with an elevated rate of structural chromosomal rearrangements and point mutations.DNA replication. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z But what about the risk of chromosomal abnormalities, such as Down's syndrome? The 300-year-old odds of having a baby 2013-09-18T00:58:27Z If you test and find you are carrying a fetus with a chromosomal issue, you face a decision about whether to continue the pregnancy. Women Need to 'Lean In' to Pregnancy, Too 2013-08-13T10:50:26Z And it screens only for major chromosomal disorders and some sex-linked diseases. Well: New DNA Test Better at Predicting Some Disorders in Babies, Study Finds 2014-02-26T22:03:51Z Hyperplastic polyps have a normal karyotype with a small subset displaying simple chromosomal aberrations. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Therefore, the relative contributions of mitotic defects and pre-mitotically generated structural chromosome abnormalities to chromosomal instability in tumours need to be explored. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z The chance of any chromosomal abnormality at the age of 20 is one in 500, he says. The 300-year-old odds of having a baby 2013-09-18T00:58:27Z Other chromosomal variations are also seen: XYY occurs in about 1 in 1,000 male births. Touching a Nerve: Exploring the Implications of the Self as Brain, Part 2 [Excerpt] 2013-07-27T13:45:00.477Z Screening of embryos in IVF is currently reserved for older women, who are at increased risk of chromosomal abnormalities, and those with recurrent miscarriages. First test-tube baby born after new, cheaper genome screening 2013-07-07T23:12:57Z When more than one cell was analysed, sibling cells from an individual patient rarely shared multiple chromosomal aberrations, but frequently possessed distinctive genomes. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Because chromosomal instability is associated with multidrug resistance and poor prognosis, this raises the possibility that this form of genome instability may also be selected for during treatment. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z "Turning that on its head, it does mean that 59 out of 60 women aged 40 will have no chromosomal problems in their baby at all." The 300-year-old odds of having a baby 2013-09-18T00:58:27Z Sometimes sexual orientation can be affected by the chromosomal and genetic variations discussed earlier. Touching a Nerve: Exploring the Implications of the Self as Brain, Part 2 [Excerpt] 2013-07-27T13:45:00.477Z Her chromosomal makeup alone generated fresh buzz for Yahoo when she was named chief executive – and disclosed simultaneously that she was pregnant. DealBook: Putting the Exclamation Point Back in Yahoo 2013-05-20T20:27:53Z DCCs from bone marrow and lymph nodes have also been shown to harbour characteristically different chromosomal aberrations. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Consistent with this idea, in vitro, microsatellite-instability colorectal cancer cell lines are more sensitive than chromosomally unstable cell lines to a range of different targeted and cytotoxic agents. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Phrases like “genetic mutation” or “chromosomal abnormality” were not part of the vernacular yet because there was no need for such language. The Story Behind a Miracle Cancer Drug [Excerpt] 2013-05-10T14:15:00.380Z During the next few years she found two other cases of chromosomal translocation in different forms of leukemia. News from the Front in War on Cancer--Mission Not Accomplished 2013-05-02T11:15:00.503Z At the end of February, the team reported that some genetic risk factors — specifically, four chromosomal sites — are associated with all five disorders: autism, attention deficit hyperactivity disorder, bipolar disorder, major depression and schizophrenia. Mental health: On the spectrum 2013-04-24T17:20:43.453Z M1/PT-like genomes have many and typical copy number alterations, chromosomal breaks, typical point mutations and evidence of clonal expansion. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z The evolution of the cancer genome may proceed not only in a gradual manner through clonal selection of point mutations or chromosomal alterations, but may also be subject to punctuated phases characterized by drastic changes. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Protecting the chromosome The protective tips of chromosomal DNA, known as telomeres, are rich in guanine and so are likely candidates for G-quadruplex structures. Four-Strand DNA Structure Found in Cells 2013-01-22T17:15:00.320Z The scientists studied just 11 pregnant women who were carrying fetuses with chromosomal abnormalities. Could a Blood Test Replace Amniocentesis? 2013-01-10T23:05:22Z Verinata Health, based in Redwood City, California, markets a test for chromosomal abnormalities, such as Down’s syndrome, that involves sequencing fetal DNA circulating in a mother’s blood. Seven days: 4–10 January 2013 2013-01-09T18:21:14.630Z Given that chromosomal abnormalities are present in nearly all human cancers, this approach represents a useful method for the noninvasive detection of human tumors that is not dependent on the availability of tumor biopsies. [Research Articles] Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing 2012-11-28T19:55:08.780Z Different instability mechanisms are also associated with variations in clinical outcome, for example, colorectal tumours with microsatellite instability are associated with a better patient prognosis compared with chromosomally unstable tumours. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z Chorionic villus sampling can detect chromosomal abnormalities such as Down syndrome ten to twelve weeks into pregnancy. Unnatural selection: is prenatal testing a triumph for reproductive freedom or brazen discrimination? 2012-09-17T23:45:00.213Z We assayed chromosomal locations for up to 12 histone modifications and variants in 46 cell types, including a complete matrix of eight modifications across tier 1 and tier 2. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Among women who were tested because an anomaly was found by ultrasound, the microarray found worrisome chromosomal variations in 5.8 percent of cases in which the standard testing found no problems. Clinical Trial Yields Positive Results for New Prenatal Test 2012-08-08T21:25:12Z We describe an approach to directly identify tumor-derived chromosomal alterations through analysis of circulating cell-free DNA from cancer patients. [Research Articles] Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing 2012-11-28T19:55:08.780Z So they engineered mice deficient in a protein that helps to maintain chromosomal integrity. How Senescent Cells Spur Aging and Cancer (preview) 2012-08-08T11:15:03.463Z Amniocentesis between fifteen and twenty weeks can find chromosomal abnormalities as well as several other genetic disorders, such as sickle cell disease, cystic fibrosis, and Tay-Sachs disease. Unnatural selection: is prenatal testing a triumph for reproductive freedom or brazen discrimination? 2012-09-17T23:45:00.213Z We sequenced the genome of Heliconius melpomene and compared it with other taxa to investigate chromosomal evolution in Lepidoptera and gene flow among multiple species and races. Butterfly genome reveals promiscuous exchange of mimicry adaptations among species 2012-07-04T17:21:31.773Z Like the plastic tips on shoelaces, telomeres protect chromosomal ends from damage. Delayed fatherhood 'extends life' 2012-06-12T02:24:47Z Some tests already sample maternal blood, but they target specific chromosomal disorders such as Down’s syndrome. Fetal Genome Deduced from Parental DNA 2012-06-07T22:15:00.207Z In contrast to Arabidopsis, but similar to soybean, tomato and potato small RNAs map predominantly to gene-rich chromosomal regions, including gene promoters. The tomato genome sequence provides insights into fleshy fruit evolution 2012-05-30T17:51:43.433Z Analyzing this DNA would allow testing for a range of genetic conditions, including one of the most common chromosomal disorders, Down syndrome, earlier in pregnancy than ever before. Unnatural selection: is prenatal testing a triumph for reproductive freedom or brazen discrimination? 2012-09-17T23:45:00.213Z Together, these results suggest that chromosomal rearrangements may contribute importantly to melanoma genesis or progression. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z Thus each of the two daughter cells presumably gets a sample of every kind of chromosomal particle, hence, the two cells are qualitatively alike. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z Bella, 3, who was born with a rare chromosomal disorder, was expected to return home soon to Virginia from the hospital, the Santorum campaign said. A Shift in Strategy in Pennsylvania for Romney 2012-04-10T01:58:00Z This enzyme attaches methyl groups to histone proteins, which are part of the chromosomal packaging. Cancer and epigenetics: Cancer?s epicentre 2012-04-03T16:18:14Z Chromothripsis is a localized shredding of a chromosomal region and subsequent random reassembly of the fragments. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z We were sitting in our family room when Rick Santorum — whose 3-year-old daughter has a different chromosomal disorder — appeared on the television. Op-Ed Contributor: Do Liberals Disdain the Disabled? 2012-02-28T02:05:14Z This parity in chromosomal contribution points clearly to the means by which an equal number of character-determiners might be conveyed from each parent. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z She suffers from a chromosomal disorder, and he offers her as the personification of his anti-abortion rights views. Santorum Deepened Faith After Child’s Death Now at Fore of Race 2012-02-24T13:37:42Z Sex is a biological state that is measure via chromosomal content and a variety of physiological and developmental measures. Get Over It: Men and Women Are from the Same Planet 2012-01-23T13:45:10.687Z Evidence from molecular, cellular and cytogenetic studies suggest that RB1 is required for maintaining chromosomal stability, and that its loss leads to chromosome instability in cells maintained in culture. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z Importantly, several of these genes were targeted by multiple mechanisms of alteration across the cohort: sequence mutation, deletion and chromosomal translocations. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z Specifically, in the low-risk category, a worse prognosis was associated with a gene expression profile that included activation of wound healing, invasiveness, chromosomal instability and deregulation of a key cancer-associated pathway. Corrected: Gene expression profiles may improve cancer prognosis 2012-01-09T19:50:40Z Many women with high-risk pregnancies are anxious about taking an amniocentesis test to determine genetic and chromosomal problems because the test carries a small risk of miscarriage. Aria Diagnostics Emerges From Stealth With New Blood-Based Prenatal Test 2012-01-07T00:38:58Z Five hundred parents consented to complete postmortem exams, which included maternal interviews, reviews of prenatal medical records, autopsies, placental evaluations, karyotyping to check for chromosomal abnormalities and other tests. Tests on fetus can help explain stillbirth, study says 2011-12-28T17:26:03Z One of the drugs, Pfizer’s Xalkori for lung , works wonders — but only for the roughly 5 percent of patients whose tumors have a particular chromosomal abnormality, as determined by a test from Abbott Laboratories. Pressure to Link Drugs and ?Companion Diagnostics? 2011-12-27T00:52:31Z Initial studies examining gross chromosomal alterations identified two subsets of patients based on the presence of unique chromosomal translocations or increased numbers of chromosomes. Perspective: A model disease 2011-12-14T18:21:18.327Z Other genes and chromosomal mutations have also yielded encouraging results. Diagnostics: The early bird 2011-12-14T18:20:59.480Z However, amniocentesis has an advantage in that it tests for a variety of chromosomal and genetic issues. Aria Diagnostics Emerges From Stealth With New Blood-Based Prenatal Test 2012-01-07T00:38:58Z What is now known, however, is that specific chromosomal translocations — where parts of one chromosome break off and attach to another — occur in myeloma cells. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z The likelihood of a woman in her twenties conceiving a chromosomally abnormal embryo is under 5 percent. Egg Timer: Separate Biological Clocks Govern Female Fertility and Life Span 2011-12-06T00:15:09.730Z At least for now, it does not detect other chromosomal abnormalities, including some rare forms of Down syndrome not caused by the triple chromosome. Sequenom?s Test for Down Syndrome Raises Hopes and Questions 2011-10-18T15:40:15Z Sequenom's MaterniT21 test detects a genetic chromosomal anomaly known as Trisomy 21, the most common cause of Down Syndrome, the company said. Sequenom launches safer test for Down Syndrome 2011-10-17T21:26:58Z The test detects only Down syndrome, which “only represents 50 percent of all the chromosomal abnormalities that you would identify through amniocentesis or C.V.S.,” he said. Sequanon?s Test for Down Syndrome Raises Hopes and Questions 2011-10-17T15:14:51Z Because chromosomal damage can promote uncontrolled cell growth, one might expect that rampant telomere erosion could introduce the same risks. Telomeres: All's well that ends well 2011-10-12T17:21:06.837Z They used Drosophila melanogaster strains heterozygous for multigene deletions to screen for chromosomal regions that reduce viability in female F1 hybrids. [Technical Comment] Comment on ?A Test of the Snowball Theory for the Rate of Evolution of Hybrid Incompatibilities? 2011-09-15T18:25:17.657Z The researchers now hope to find the sites within the chromosomal region and learn how the area works in other closely related species. Butterfly Uses "Supergene" to Mimic Other Toxic Species [Video] 2011-08-17T20:45:00.457Z Privately-held Gene Security Network is also currently testing its prenatal diagnostic test to detect chromosomal anomalies by analyzing fragments of fetal DNA. Sequenom launches safer test for Down Syndrome 2011-10-17T21:26:58Z To be activated they must be liberated from the chromosomal coils. AIDS: No hiding place 2011-07-21T11:24:00Z What this work shows is that a lot of the chromosomal abnormalities are not those that are conventionally age-related. IVF procedure 'may cause Down's' 2011-07-04T01:44:48Z Because wild-type female hybrids are never hemizygous for chromosomal regions, it is essential to consider how the putative DM HI regions identified in their screen would function in normal hybrids. [Technical Comment] Comment on ?A Test of the Snowball Theory for the Rate of Evolution of Hybrid Incompatibilities? 2011-09-15T18:25:17.657Z To identify fusion genes in gastric cancer, we analyzed regions of chromosomal imbalance in a cohort of 106 primary gastric cancers and 27 cell lines derived from gastric cancers. [Research Articles] CD44-SLC1A2 Gene Fusions in Gastric Cancer 2011-04-06T18:55:10.887Z Down Syndrome is a chromosomal disorder that affects infants, resulting in impaired cognitive ability and abnormal facial features. Sequenom launches safer test for Down Syndrome 2011-10-17T21:26:58Z Dr. Epstein was best known for his work on Down syndrome, a chromosomal condition that affects roughly 1 in 700 newborns. Charles Epstein, Leading Medical Geneticist Injured by Unabomber, Dies at 77 2011-02-24T03:07:42Z If a stalled replication fork persists for too long, they can collapse and lead to the chromosomal instability that is cytological hallmark of FA. Doctor, what's wrong with my child?--What Guido Fanconi taught us about chemotherapy 2011-02-14T14:15:00.247Z Detailed examination of these chromosomal rearrangements revealed a distinctive pattern of balanced breaking and rejoining not previously observed in solid tumours: several genomes contained complex inter- and intra-chromosomal events involving an exchange of ‘breakpoint arms’. The genomic complexity of primary human prostate cancer 2011-02-09T18:22:53.550Z But challenges remain: chromosomal movements are dynamic and non-deterministic, so detecting what is where, and when, is difficult. Genomics: Genomes in three dimensions 2011-02-09T18:22:32.850Z With them, chromosomes 8 and 21 were broken and had switched ends — the first known chromosomal translocation. A Conversation With Janet D. Rowley: The Matriarch of Modern Cancer Genetics 2011-02-07T20:20:04Z The left image of and the right image of are DAPI-only images that show the primary constriction of both chromosomal forms, indicated by the arrows. Comparative and demographic analysis of orang-utan genomes 2011-01-26T18:22:58.603Z Unaffected patients are able to tolerate and repair most of the damage caused by these agents whereas FA patients have a heightened level of chromosomal breakage. Doctor, what's wrong with my child?--What Guido Fanconi taught us about chemotherapy 2011-02-14T14:15:00.247Z By reconstructing the exact pattern of chromosomal rearrangements, he and colleagues found it could not be explained by the standard process in which one mutation is acquired after another in a protracted series. Cancer Can Develop in Catastrophic Burst 2011-01-10T20:20:04Z Chromatin signatures also identify functional elements involved in other chromosomal processes such as duplication and segregation. [Research Article] Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE 2011-01-05T15:57:51.363Z Contrary to what had been thought, the Philadelphia chromosome didn’t represent a deletion of chromosomal material. A Conversation With Janet D. Rowley: The Matriarch of Modern Cancer Genetics 2011-02-07T20:20:04Z The left image of and the right image of are DAPI-only images that show the primary constriction of both chromosomal forms, indicated by the arrows. Comparative and demographic analysis of orang-utan genomes 2011-01-26T18:22:58.603Z Shortly thereafter, multiple groups showed that patients afflicted with FA suffered from chromosomal instability that was spontaneous but also exaggerated by treatment with DNA-crosslinking substances. Doctor, what's wrong with my child?--What Guido Fanconi taught us about chemotherapy 2011-02-14T14:15:00.247Z We constructed hierarchical networks of transcription factor–binding and microRNA interactions and discovered chromosomal locations bound by an unusually large number of transcription factors. [Research Article] Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project 2011-01-05T01:55:48.427Z "Now we have a new technology...and our hopes are that this will finally provide a reliable means of assessing the chromosomal status of the embryos we transfer." First babies born in IVF full gene screening study 2010-10-15T13:24:00Z Her daughter Sadie was born with a rare chromosomal disorder and is now 5. State facilities for the disabled called antiquated, but some rely on them 2010-07-22T04:00:00Z "Ten percent of the chromosomal males become completely, functionally female," Hayes said in a telephone interview. Study: Herbicide upsetting some animals' hormone systems 2010-03-01T20:36:00Z On the basis of the blood test results the woman may opt for a Chorionic Villus sample or an amniocentesis which would diagnose Down's syndrome or other chromosomal abnormalities. 2009-09-02T17:06:00Z These megabase-scale chromosomal domains are not homogeneous; there are small zones of repressive marks within the generally active central regions and active marks within the generally repressed arms. [Research Article] Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project 2011-01-05T01:55:48.427Z All of these conditions are associated with a higher than average rate of embryonic chromosomal abnormality. First babies born in IVF full gene screening study 2010-10-15T13:24:00Z The distinctive combination of morphological, physiological, chromosomal, and behavioral characteristics is strongly suggestive that these frogs represent an early phyletic divergence within the Hylidae. The Genera of Phyllomedusine Frogs (Anura Hylidae) In the case of the sterile hybrid transformed into fertile individuals, no counting of chromosomes is necessary because restoration of fertility is evidence of changes in the chromosomal makeup. Northern Nut Growers Association Report of the Proceedings at the 43rd Annual Meeting Rockport, Indiana, August 25, 26 and 27, 1952 In others, chromosomal aberrations occur, resulting in mutations. Attrition Several species of nuts are among this class of plants with doubled chromosomal numbers, however, such duplications occurred in nature. Northern Nut Growers Association Report of the Proceedings at the 43rd Annual Meeting Rockport, Indiana, August 25, 26 and 27, 1952 |
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