| 单词 | cholinesterase |
| 例句 | The power of the organic phosphates, those poisoners of the nerve-protective enzyme cholinesterase, may become greater if the body has first been exposed to a chlorinated hydrocarbon which injures the liver. Silent Spring 1962-09-27T00:00:00Z Repeated exposures may lower the cholinesterase level until an individual reaches the brink of acute poisoning, a brink over which he may be pushed by a very small additional exposure. Silent Spring 1962-09-27T00:00:00Z A protective enzyme called cholinesterase is at hand to destroy the transmitting chemical once it is no longer needed. Silent Spring 1962-09-27T00:00:00Z This is because, when liver function is disturbed, the cholinesterase level drops below normal. Silent Spring 1962-09-27T00:00:00Z The balance is delicate and government veterinarians have found that repeated small doses can gradually deplete an animal’s supply of the protective enzyme cholinesterase, so that without warning a minute additional dose will cause poisoning. Silent Spring 1962-09-27T00:00:00Z This chemical, like parathion and its relatives, destroys the protective enzyme cholinesterase. Silent Spring 1962-09-27T00:00:00Z Novichok belongs to a broad class of compounds called cholinesterase inhibitors, which are used in a wide range of medicines as well as poisons. What Is Novichok, the Nerve Agent Tied to Navalny Poisoning? 2020-09-02T04:00:00Z German doctors announced Aug. 24 that he showed symptoms of poisoning with a cholinesterase inhibitor, a class of chemical agents that includes Novichok and other nerve agents. Russian opposition leader Navalny poisoned with nerve agent similar to Novichok, Germany says 2020-09-02T04:00:00Z Novichok is part of a class of cholinesterase inhibitors, which prevent nerves from giving “messages” to muscles, triggering a cascade of collapse of bodily functions. Novichok nerve agent used against Russian dissident has dark history 2020-09-02T04:00:00Z It is a cholinesterase inhibitor, part of the class of substances that doctors at the Berlin hospital the Charité initially identified in Navalny. Alexei Navalny poisoned with Novichok, says German government 2020-09-02T04:00:00Z Last weekend, he was moved to the Charité hospital in Berlin, where doctors found indications of “cholinesterase inhibitors” in his system. World Digest: Aug. 28, 2020 2020-08-28T04:00:00Z He was transferred at the weekend to the Charité hospital in Berlin, where doctors found indications of “cholinesterase inhibitors” in his system. Alexei Navalny showing some improvement but still in coma 2020-08-28T04:00:00Z Last weekend, he was transferred to the Charité hospital in Berlin, where doctors found indications of “cholinesterase inhibitors” in his system. Hospital: Russia’s Navalny still in coma but improving 2020-08-28T04:00:00Z Found in some drugs, pesticides and chemical nerve agents, cholinesterase inhibitors act by blocking the breakdown of a key chemical in the body, acetycholine, which transmits signals between nerve cells. Russia announces preliminary probe into Navalny’s illness 2020-08-27T04:00:00Z Once he was evacuated to Berlin, doctors at the Charité hospital said, “Clinical findings indicate poisoning with a substance from the group of cholinesterase inhibitors.” Opinion | Alexei Navalny can’t just become another name on the roll call of Putin’s victims 2020-08-26T04:00:00Z Found in some drugs, pesticides and chemical nerve agents, cholinesterase inhibitors block the breakdown of a key chemical in the body, acetylcholine, that transmits signals between nerve cells. World Digest: Aug. 28, 2020 2020-08-28T04:00:00Z Over the weekend, he was transferred to the Charité hospital in Berlin, where doctors found indications of “cholinesterase inhibitors” in his system. Pressure mounts on Russia to investigate Navalny’s poisoning 2020-08-26T04:00:00Z Found in some drugs, pesticides and chemical nerve agents, cholinesterase inhibitors block the breakdown of a key chemical in the body, acetycholine, that transmits signals between nerve cells. Hospital: Russia’s Navalny still in coma but improving 2020-08-28T04:00:00Z German doctors treating him in Berlin said on Monday that medical examinations indicated poisoning with some kind of cholinesterase inhibitor. Navalny ally says only Putin could have authorised suspected poisoning 2020-08-26T04:00:00Z Navalny did not display “a clinical pattern characteristic of a poisoning by cholinesterase inhibitors,” he added. Kremlin rejects Navalny poisoning diagnosis in Germany as calls grow for probe 2020-08-25T04:00:00Z Now fighting for his life in Berlin's Charité hospital, Mr Navalny is in an induced coma, being treated for "poisoning with a substance from the group of cholinesterase inhibitors". Navalny and Russia’s arsenal of exotic poisons 2020-08-25T04:00:00Z The cholinesterase inhibitors found in Navalny’s system reportedly block the breakdown of acetycholine, a vital chemical that transmits signals between nerve cells. Russia rejects investigation of opposition leader's alleged poisoning 2020-08-25T04:00:00Z The Charité hospital says that "clinical evidence suggests an intoxication through a substance belonging to the group of cholinesterase inhibitors". Kremlin dismisses claims Putin poisoned Navalny 2020-08-25T04:00:00Z The specific substance is not yet known but cholinesterase inhibitors are a group of chemical compounds used in medicines o alleviate symptoms of Alzheimers and other kinds of dementia. Navalny ally says only Putin could have authorised suspected poisoning 2020-08-26T04:00:00Z It said, however, that he was affected by a cholinesterase inhibitor, a chemical that blocks the transmission of impulses through the nervous system. Kremlin rejects Navalny poisoning diagnosis in Germany as calls grow for probe 2020-08-25T04:00:00Z But the poison's effect - inhibition of the enzyme cholinesterase in the body - "was confirmed by multiple tests in independent laboratories". Navalny and Russia’s arsenal of exotic poisons 2020-08-25T04:00:00Z German doctors treating Navalny at a Berlin hospital said on Monday that medical examinations indicated poisoning with some kind of cholinesterase inhibitor, although the specific substance is not yet known. Kremlin says no reason for now to investigate Alexei Navalny's illness 2020-08-25T04:00:00Z The Kremlin says Russian doctors also noted lowered cholinesterase levels and administered atropine, but found no evidence of poisoning. Kremlin dismisses claims Putin poisoned Navalny 2020-08-25T04:00:00Z A Russian health ministry issued a statement challenging the German findings, saying Mr. Navalny’s symptoms were not consistent with cholinesterase inhibitors. Aleksei Navalny, Putin Critic in a Coma, Was Poisoned, German Doctors Say 2020-08-24T04:00:00Z Atropine is the most common treatment for poisoning by a cholinesterase inhibitor. Prominent Russian opposition activist Navalny was poisoned, German doctors say 2020-08-24T04:00:00Z “The team of doctors examined the patient in detail after his arrival. The clinical findings indicate poisoning by a substance from the group of active substances called cholinesterase inhibitors,” the hospital said in a statement. Russian opposition leader Navalny shows indications of poisoning: German hospital 2020-08-24T04:00:00Z The Charite hospital released a statement saying "clinical evidence suggests an intoxication through a substance belonging to the group of cholinesterase inhibitors". Evidence Navalny was poisoned - Berlin hospital 2020-08-24T04:00:00Z Specifically, the results were "highly suggestive" of something called cholinesterase inhibitor intoxication. Cuba's 'sonic weapon' may have been mosquito gas 2019-09-20T04:00:00Z They found that a key enzyme required for proper brain functioning of the nervous system called cholinesterase was being blocked. ‘Sonic weapon’ used on diplomats in Cuba may have been pesticide, study finds 2019-09-20T04:00:00Z They then concluded that cholinesterase, a key enzyme required for the proper functioning of the nervous system, was being blocked there. Mosquito fumigation may have caused mystery 'Havana syndrome', study says 2019-09-19T04:00:00Z There are two types of medications approved for the treatment of dementia — cholinesterase inhibitors and memantine — which work to improve symptoms like memory loss and confusion. Older adults overprescribed dementia medication at high cost: Study 2018-08-21T04:00:00Z Fortunately, the body has its own protective device against this peril—an enzyme called cholinesterase, which breaks down the transmitting chemical once it is no longer needed. Silent Spring—I 2017-01-03T05:00:00Z It acts by blocking an enzyme called cholinesterase, which causes a toxic buildup of acetylcholine, an important protein that carries signals from nerve cells to their targets. A Strong Case Against a Pesticide Does Not Faze E.P.A. Under Trump 2017-05-15T04:00:00Z They then noted that certain classes of pesticides work by inhibiting cholinesterase and that Cuba, like many other tropical islands, regularly sprays pesticides to kill insects that carry diseases. ‘Sonic weapon’ used on diplomats in Cuba may have been pesticide, study finds 2019-09-20T04:00:00Z Some pesticides work by inhibiting cholinesterase, the report said, and during the 2016-2018 period when diplomats became ill normal fumigation in Cuba was stepped up due to the Zika epidemic in the Caribbean. Mosquito fumigation may have caused mystery 'Havana syndrome', study says 2019-09-19T04:00:00Z Total drug costs were highest for patients prescribed memantine and cholinesterase inhibitors together. Older adults overprescribed dementia medication at high cost: Study 2018-08-21T04:00:00Z Repeated exposure may lower the cholinesterase level until an individual reaches the brink of acute poisoning—a brink over which he may be pushed by a very small additional exposure. Silent Spring—I 2017-01-03T05:00:00Z The investigators assessed weight loss for people taking newly prescribed cholinesterase inhibitors versus weight loss experienced by those taking other types of newly prescribed medications. Dementia Meds May Lead to Harmful Weight Loss: Study 2015-08-03T04:00:00Z Organophosphate pesticides are a class of chemicals called irreversible cholinesterase inhibitors, meaning that they permanently block the enzyme that degrades the neurotransmitter, acetylcholine. Crocodile Bile Expert Suspects Toxic Pesticide In Mozambique Tainted Beer Tragedy 2015-01-14T05:00:00Z The reason sage may have an effect is because it contains a cholinesterase inhibitor, a chemical which prevents the breakdown of the neurotransmitter, acetylcholine. Unexpected ways to wake up your brain 2014-10-29T04:00:00Z Other drugs that were questionably prescribed included some intended for the treatment of early stage dementia, such as cholinesterase inhibitors and memantine, the researchers said. Advanced Dementia Patients Often Given Unhelpful Meds: Study 2014-09-11T04:00:00Z The balance is very delicate indeed, and government veterinarians have found that repeated small doses can gradually deplete an animal’s supply of cholinesterase, so that without warning a minute additional dose will cause poisoning. Silent Spring—I 2017-01-03T05:00:00Z So, when weight loss becomes a concern, "timely discontinuation of cholinesterase inhibitors should be actively considered as demented patients progress in their disease," she said. Dementia Meds May Lead to Harmful Weight Loss: Study 2015-08-03T04:00:00Z So the society urges extensive discussion before doctors prescribe cholinesterase inhibitors and suggests no more than a three-month trial. The New Old Age Blog: Geriatricians Question Five Common Treatments 2014-03-07T20:51:10Z The authors emphasize that only a clinical trial could prove a causal relationship, but they suggest several possible reasons for the effect, including the anti-inflammatory properties of cholinesterase inhibitors. Well: Patterns: Alzheimer's Drugs May Protect Heart 2013-06-04T23:05:58Z Aricept and several drugs like it work by keeping an enzyme called cholinesterase from breaking down acetylcholine, an important neurotransmitter for memory and thinking that declines as Alzheimer's progresses. New drug for Alzheimer's symptom relief shows promise 2012-07-18T15:30:30Z Aircept — or donepezil — is a cholinesterase inhibitor that improves mental function by increasing the occurrence of natural substances that enable healthy brain activity. Facts, awareness are key to dealing with Alzheimer's disease 2011-11-07T17:05:04Z There was moderate evidence that neither vitamin E nor drugs called cholinesterase inhibitors, used to treat dementia symptoms, decrease risk of Alzheimer’s. News Analysis: Grasping for Any Way to Prevent Alzheimer?s 2011-07-25T21:30:30Z Topping this year’s list is a caution against dementia drugs called cholinesterase inhibitors — Arricept is the most widely used — without following up to see whether they’re really helping. The New Old Age Blog: Geriatricians Question Five Common Treatments 2014-03-07T20:51:10Z After adjusting for sex, age, previous cardiovascular disease, additional prescribed drugs and other factors, the researchers found that taking cholinesterase inhibitors reduced both the death rate and the heart attack rate by about 35 percent. Well: Patterns: Alzheimer's Drugs May Protect Heart 2013-06-04T23:05:58Z There was also moderate evidence that cholinesterase inhibitors, drugs often used to treat Alzheimer's symptoms, had no effect. Panel: No magic bullet against Alzheimer's 2010-08-28T23:24:00Z There was also moderate evidence that cholinesterase inhibitors, drugs often used to treat Alzheimer’s symptoms, had no effect. Years Later, No Magic Bullet Against Alzheimer?s Disease 2010-08-28T23:02:00Z Critically ill patients are not usually prescribed cholinesterase inhibitors, but even excluding patients who died within three months changed the association only slightly. Well: Patterns: Alzheimer's Drugs May Protect Heart 2013-06-04T23:05:58Z |
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