| 单词 | adenosine |
| 例句 | As we go about our days and do things, levels of adenosine rise because it is released as a byproduct as energy is used in our cells. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z But it is not so similar that it triggers the drowsy slowdown signal like adenosine does. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z It works by binding to the adenosine receptor, which it can do because it is a similar shape. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z This is because the caffeine won't bind forever, and the adenosine that it blocks doesn't go away. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z And we are all battery-operated, deriving energy from a molecule called adenosine triphosphate, ATP for short. Just a Few Billion Years Left to Go 2020-02-17T05:00:00Z Instead, it just fills the spots and stops the adenosine from binding there. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z While we are sleeping, energy use drops, lowering adenosine levels as it gets shuffled back into other forms. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z This theory is supported by research that indicates that needle insertion prompts the flow of adenosine, a chemical that reduces inflammation. So you want to give acupuncture a try. How do you pick a provider? 2021-10-03T04:00:00Z Only some of the energy is trapped in phosphate bonds of adenosine triphosphate. Our godless brains: Emerging science reveals mind-blowing alternatives to a higher power 2014-04-26T20:00:00Z So, eventually, the caffeine breaks down, lets go of the receptors and all that adenosine that has been waiting and building up latches on and the drowsy feeling comes back — sometimes all at once. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z The main stimulant in coffee is caffeine, and the main way caffeine works is by changing the way the cells in our brain interact with a compound called adenosine. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z How much free adenosine is in your system that hasn't attached to receptors yet — and how drowsy you are as a consequence — will impact how much the caffeine you drink wakes you up. Nope, coffee won’t give you extra energy 2023-02-03T05:00:00Z This translated into rhythms of energy through rise and fall of production of adenosine triphosphate or ATP, the body's cellular source of energy. Bear genes show circadian rhythms even during hibernation 2023-11-16T05:00:00Z As a result, the T cells are forced to switch to alternative metabolic pathways, mainly aerobic glycolysis, to meet their bioenergetic demand in the form of adenosine triphosphate. Immunology: Dysfunction of mitochondria drives the exhaustion of T cells 2023-11-02T04:00:00Z Scientists have also proposed that a brain chemical called adenosine can influence migraine. Can a Bad Night’s Sleep Trigger a Migraine? 2023-10-25T04:00:00Z The work yielded a rich enough dataset to show that any of three adenosine nucleotides encoding two amino acids in the C-terminus could be swapped for another, yielding eight different editions of the protein. Individual neurons mix multiple RNA edits of key synapse protein, fly study finds 2023-09-18T04:00:00Z When an ATP molecule is used, it is stripped of one of its phosphate groups, creating adenosine diphosphate, or ADP. Chemists convert electricity into the fuel that powers the body’s cells 2023-08-22T04:00:00Z "We know, as adults, when you've been awake so long, adenosine is a chemical that builds up. And the way to dump out that adenosine is to sleep," Dumaplin said. Online, the baby sleep business is booming 2023-05-12T04:00:00Z Caffeine works by getting in the way of a chemical the body makes called adenosine. Six simple ways to improve your "sleep hygiene," according to experts 2023-01-29T05:00:00Z As adenosine accumulates throughout the day, it slows down excitatory networks such as the arousal-causing reticular activating system. Can a Bad Night’s Sleep Trigger a Migraine? 2023-10-25T04:00:00Z The body stores and burns energy by perpetually making and breaking the phosphate bonds found in the cell’s little cash machines, its adenosine triphosphate molecules, better known as ATP. The Sad Fate of the Ancient, Well-Shelled Mariners 2022-11-04T04:00:00Z This is in part the consequence of the accumulation of chemical signals released by neurons, such as adenosine. Back-to-school season brings sleep deprivation 2022-09-25T04:00:00Z It has an adenosine backbone with three phosphate groups attached. Biology for AP Courses 2022-06-09T00:00:00Z As adenosine levels increase, so does the feeling of fatigue. Six simple ways to improve your "sleep hygiene," according to experts 2023-01-29T05:00:00Z One speculation is that there is an abnormally high concentration of adenosine in the brain during a migraine. Can a Bad Night’s Sleep Trigger a Migraine? 2023-10-25T04:00:00Z This is a modified, smooth muscle cell lining the afferent arteriole that can contract or relax in response to ATP or adenosine released by the macula densa. Anatomy and Physiology 2013-06-19T00:00:00Z Spikes of adenosine had been consistently observed in sleep-deprived rats and humans. The Sleep Debt Collector is Here 2022-06-24T04:00:00Z Although it’s not yet clear just what scientists will do with this 26-atom rotary motor, a larger biological analog uses rotational motion to generate adenosine triphosphate, the fuel used by cells to do work. Tiny labmade motors could one day suck pollutants from the air and harvest precious metals 2022-04-05T04:00:00Z But the more caffeine you consume, the more adenosine the body produces. Six simple ways to improve your "sleep hygiene," according to experts 2023-01-29T05:00:00Z It may also be why caffeine—a stimulant that blocks adenosine’s effects—can be helpful during a migraine, adds Charles, who recently studied the effects of caffeine on sleep in mice. Can a Bad Night’s Sleep Trigger a Migraine? 2023-10-25T04:00:00Z In the breakdown of glucose for energy, molecules of adenosine triphosphate, better known as ATP, are produced. Anatomy and Physiology 2013-06-19T00:00:00Z A rare, aggressive form in children results from a mutation in a gene for a metabolic enzyme called adenosine deaminase 2. In Autoimmune Disease, Organs May Lure the Immune System into an Attack 2021-09-14T04:00:00Z As that ATP gets expended — as we think, exercise, run errands or sit on conference calls — our cells generate a chemical called adenosine as a byproduct. Why does coffee sometimes make you tired? 2021-09-13T04:00:00Z This can make it hard to quit, because once you do, a flood of adenosine will give many people headaches or make them extra tired. Six simple ways to improve your "sleep hygiene," according to experts 2023-01-29T05:00:00Z His work has shown that these patients usually have poorly functioning mitochondria — organelles that provide energy to cells in the form of adenosine triphosphate, or ATP. Recovery from an ICU stay is tough. Could more protein help? 2021-08-29T04:00:00Z Caffeine is an antagonist to a different neurotransmitter receptor, called the adenosine receptor. Anatomy and Physiology 2013-06-19T00:00:00Z When near amyloid plaques, they did not produce sufficient adenosine triphosphate, or ATP, a molecule that fuels cellular activity. Immune Cells Suggest New Alzheimer’s Treatment Possibilities 2021-07-26T04:00:00Z That adenosine goes on to bind to receptors in the brain, making us more sleepy. Why does coffee sometimes make you tired? 2021-09-13T04:00:00Z Caffeine locks into the same receptor in the brain as the neurotransmitter adenosine, a natural sedative. The Health Benefits of Coffee 2021-06-14T04:00:00Z The disease at issue is severe combined immunodeficiency due to adenosine deaminase deficiency, or ADA-SCID. Column: California's stem cell program found a disease cure, but it's being blocked by a biotech firm 2021-05-24T04:00:00Z NO has the opposite effect, relaxing the afferent arteriole at the same time ATP and adenosine are stimulating it to contract. Anatomy and Physiology 2013-06-19T00:00:00Z As of last year, according to Scientific American, the FDA had approved nine gene therapies, which for the most part target rare physiological disorders, such as adenosine deaminase deficiency and lipoprotein lipase deficiency. Premature Freakouts about Techno-Enhancement 2021-01-23T05:00:00Z Chemically, caffeine looks similar enough to adenosine on the molecular level that it occupies those binding sites, preventing adenosine from binding to those brain receptors. Why does coffee sometimes make you tired? 2021-09-13T04:00:00Z It is possible that spermidine acts to increase such anti-inflammatory signalling from the adenosine receptors. Ghostly metabolic messages from dying cells 2020-03-17T04:00:00Z Mitochondria are essential for breaking down oxygen to produce adenosine which provides energy to drive many processes in living cells. Scientists discover first animal that can survive without oxygen 2020-02-27T05:00:00Z To get a little nerdy and "sciencey" for a second, the theory is that caffeine blocks something called adenosine receptors in the brain. Can Avoiding Caffeine Boost Your Athletic Performance? 2020-02-08T05:00:00Z These proteins bind to RNAs and alter their sequence by changing a familiar base known as adenosine into a molecule called inosine. Step aside CRISPR, RNA editing is taking off 2020-02-03T05:00:00Z Meanwhile, adenosine continues to build up in the body. Why does coffee sometimes make you tired? 2021-09-13T04:00:00Z Caffeine acts as a molecular mimic, filling and blocking the adenosine receptor, preventing the body's natural ability to be able a rest when it's tired. The biology of coffee, one of the world’s most popular drinks 2020-01-26T05:00:00Z When one consumes caffeine, it binds to adenosine receptors in the brain, which allows dopamine to move more smoothly. Some coffee drinkers claim it causes anxiety. Here's what the science says 2019-11-24T05:00:00Z In 2016, a drug called Strimvelis was approved in Europe for the treatment of a condition called adenosine deaminase severe combined immunodeficiency, or ADA-SCID, a form of the disease that afflicted David Vetter. Stem-cell and genetic therapies make a healthy marriage 2019-05-14T04:00:00Z Caffeine is a stimulant that works primarily by blocking the receptor for adenosine, a neurotransmitter that causes relaxation, Benowitz says. Why Big Tobacco and Big Vape love comparing nicotine to caffeine 2019-04-26T04:00:00Z Our liver adapts by making proteins that break down caffeine faster, and the adenosine receptors in our brain multiply, so that they can continue to be sensitive to adenosine levels to regulate our sleep cycle. Why does coffee sometimes make you tired? 2021-09-13T04:00:00Z It seems to work as a stimulant, at least in part, by blocking adenosine, which promotes sleep, from binding to its receptor. The biology of coffee, one of the world’s most popular drinks 2020-01-26T05:00:00Z After the binge session, mice did not experience an increase in the sleep promoting chemical adenosine. Single alcohol binge-drinking session changes DNA, disrupts sleep 2018-06-19T04:00:00Z In patients with ADA-SCID, an inherited mutation in the ADA gene affects the production of the adenosine deaminase enzyme, which is essential for immune-system function. Stem-cell and genetic therapies make a healthy marriage 2019-05-14T04:00:00Z Sleepiness is caused by a build-up of the chemical adenosine in the brain. Reality Check: Do power naps do any good? 2017-12-15T05:00:00Z Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Structure of PINK1 in complex with its substrate ubiquitin 2017-10-29T04:00:00Z At least some of this variation is from having different forms of that adenosine receptor, the molecule that caffeine binds to and blocks. The biology of coffee, one of the world’s most popular drinks 2020-01-26T05:00:00Z This theory is supported by research that indicates needle insertion prompts the flow of adenosine, a chemical that reduces inflammation. Interested in acupuncture? A look at Seattle-area options 2017-11-24T05:00:00Z We evolved a tRNA adenosine deaminase to operate on DNA when fused to a catalytically impaired CRISPR-Cas9. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage 2017-10-24T04:00:00Z The caffeine in coffee works by blocking the brain's adenosine receptors, while sleep gets rid of it altogether. Reality Check: Do power naps do any good? 2017-12-15T05:00:00Z Gene therapy for immunodeficiency due to adenosine deaminase deficiency. Regeneration of the entire human epidermis using transgenic stem cells 2017-11-07T05:00:00Z Not only does adenosine ramp up in winter in ground squirrels, the receptors for the molecule become more sensitive to it. Animals Don't Actually Sleep for the Winter, and Other Surprises About Hibernation 2017-10-12T04:00:00Z Previous research established that adenosine also helps us taste sweet flavors. This part of your morning routine could be causing your afternoon sugar craving 2017-08-29T04:00:00Z One mainstream theory in acupuncture research is this temporary pain relief stems from the release of a natural painkiller called adenosine around the insertion point. Pet acupuncture: Would you try this alternative treatment? - BBC News 2017-08-22T04:00:00Z These developmental windows seem to be controlled by a molecule called adenosine, levels of which rise after the critical period closes. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z Altitude raised blood levels of adenosine, which dilates blood vessels, boosting blood flow. Physiology: Cells remember high altitude : Nature : Nature Research 2017-02-14T05:00:00Z The drug inhibits compounds called adenosine receptors that dilate blood vessels in the brain, resulting in constricted vessels, the study said. Frequent Testing for Nickel Allergies May Prevent Them 2016-09-19T04:00:00Z The team is now trying to learn how adenosine signals stem cells to create bone. In Mice, a Way for Stem Cells to Build Bone 2016-08-31T04:00:00Z It also built proteins and used adenosine triphosphate as its currency for energy. Our last common ancestor inhaled hydrogen from underwater volcanoes 2016-07-25T04:00:00Z “If disrupting adenosine signaling produces improvements in cortical plasticity but also hearing problems such as tinnitus, then it would not be an effective means of improving auditory perception in humans.” Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z The team found that adenosine also helps to degrade a protein called eENT1 in red blood cells in humans and mice, causing increased production of adenosine during the first exposure to low oxygen. Physiology: Cells remember high altitude : Nature : Nature Research 2017-02-14T05:00:00Z The researchers suggest that chronic caffeine consumption may trigger a compensatory effect that results in elevated adenosine concentrations, potentially interfering with the effectiveness of triptans. Frequent Testing for Nickel Allergies May Prevent Them 2016-09-19T04:00:00Z The research team found that adding adenosine to the stem cell process helped build bone tissue in mice without any teratoma formation. In Mice, a Way for Stem Cells to Build Bone 2016-08-31T04:00:00Z Eventually, Obokata—a chemist—discovered that she got the most consistent spheres by bathing the cells in a solution of adenosine triphosphate, a cellular fuel that also happens to be mildly acidic. The Stem-Cell Scandal 2016-02-29T05:00:00Z Responses were compared with those from animals genetically engineered to lack the cell surface receptor to which adenosine binds. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z There's also the homeostatic sleep-wake system, which causes the buildup of a chemical called adenosine. Drinking coffee late at night can throw your internal clock out of sync 2015-09-16T04:00:00Z In his cells, the complex process powering his heart and lungs and legs – the burning and resynthesising of adenosine triphosphate – created three times as much heat as energy. Fast times: what will it take to run the marathon in under two hours? 2015-06-27T04:00:00Z The team of scientists from the University of California, San Diego used a naturally occurring molecule called adenosine to prompt human stem cells to regenerate bone tissue. In Mice, a Way for Stem Cells to Build Bone 2016-08-31T04:00:00Z However, those adenosine triphosphate tests are not regulated by the FDA, and the agency said the "ability of these products to predict whether bacteria will survive on a duodenoscope after reprocessing is unknown." Hospitals step up search for best scope-cleaning protocol 2015-05-14T04:00:00Z Increased adenosine, he says, reduces the release of the signaling molecule glutamate in the thalamus, which in turn diminishes the activity of neurons in the auditory cortex. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z She believes she has found the molecule that does the job, the A1 adenosine receptor. Hibernation for humans may not be a pipe dream forever 2015-04-13T04:00:00Z Lots of research is underway to develop drugs that would block the adenosine effect. Breathing extra oxygen helped shrink lung tumors in mice 2015-03-09T04:00:00Z The stimulant works partly by blocking the effects of adenosine, a brain chemical that mirrors the natural drive to sleep over the day, Grandner says. 7 Reasons You're Waking Up All Wrong 2015-01-21T05:00:00Z A 20-minute nap ends just as the caffeine kicks in and clears the brain of a molecule called adenosine, maximizing alertness. 6 Strange But True Health Tips 2014-10-18T04:00:00Z The analysis revealed cells in the auditory cortex of mice lacking the adenosine receptor responded to a larger range of frequencies than those of the wild-type mice. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z According to the video, above, when you're awake, a chemical called adenosine accumulates in the brain. VIDEO: What coffee does to your brain 2014-09-02T04:00:00Z Chemically, it is similar to adenosine, one of the four letters of the genetic code. BioWar Lab Develops Cure For Ebola 2014-08-04T04:00:00Z However, activated astrocytes can also help to reduce seizure intensity: they contribute to the production of adenosine, a signalling molecule that can counter the effects of glutamate. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z Caffeine blocks adenosine, the byproduct of active cells that drives you to sleep as it accumulates, he explains. 14 Reasons You're Tired All the Time 2014-06-08T04:00:00Z To investigate further, Blundon and his colleagues inhibited adenosine signaling in several other ways. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z The more adenosine, the more tired you feel. VIDEO: What coffee does to your brain 2014-09-02T04:00:00Z In the body it blocks the effects of the molecule adenosine, a crucial brake on many physiologic processes. Books: “Caffeinated,” a History of Our Favorite Stimulant 2014-03-24T18:45:43Z In short, adenosine turns down the neural signals that glutamate turns up, and that could reduce seizure activity, explains Carmignoto. Neurobiology: Unrestrained excitement : Nature : Nature Publishing Group 2014-07-08T04:00:00Z Glucose and adenosine triphosphate, for example, are high-energy molecules in ample supply in mammals. Sea creatures may offer clues to such vexing problems of medical science as paralysis 2014-03-17T20:11:13Z In the latest study the researchers wanted to determine if halting adenosine signaling would reinstate plasticity in the auditory cortex. Can Hearing Be Restored by Making the Brain More Childlike? 2017-06-29T04:00:00Z Caffeine happens to have a similar structure to adenosine, causing it to compete with adenosine in the brain. VIDEO: What coffee does to your brain 2014-09-02T04:00:00Z Without enough rest, adenosine builds up and may start to degrade communication between networks in the brain, Dr. Walker said. Wel: How Sleep Loss Adds to Weight Gain 2013-08-06T15:10:27Z As discussed in a previous article, caffeine acts as an expert mimic of a chemical called adenosine in the brain and other parts of the body. Will A Few Cups Of Coffee A Day Keep The Blues Away? 2013-07-28T21:39:00Z Prof Bobby Gaspar, from Great Ormond Street Hospital in London is working on a Medical Research Council trial using gene therapy as a treatment for adenosine deaminase deficiency - which also leads to immune problems. Gene therapy trial 'cures children' 2013-07-11T18:04:20Z He says it's linked to a chemical called adenosine. Caffeine nation - Am I an addict? 2013-07-09T23:33:34Z When the adenosine can no longer bind with the receptors, the tired feeling the chemical causes goes away. VIDEO: What coffee does to your brain 2014-09-02T04:00:00Z Dr. Walker said he suspected that one factor that plays a role is a substance called adenosine, a metabolic byproduct that disrupts neural function and promotes sleepiness as it accumulates in the brain. Wel: How Sleep Loss Adds to Weight Gain 2013-08-06T15:10:27Z By mimicking adenosine, caffeine blocks receptors in the nervous system from receiving the signals to decrease energy expenditure. Will A Few Cups Of Coffee A Day Keep The Blues Away? 2013-07-28T21:39:00Z The difference is that Keeling’s parasites steal energy, in the form of a molecule called adenosine triphosphate or ATP, from their hosts, but they possess the necessary genes to replicate DNA. Tiny Genomes May Offer Clues to First Plants and Animals 2013-06-24T15:15:00.317Z It takes the brake off adenosine's natural inhibiting function. Caffeine nation - Am I an addict? 2013-07-09T23:33:34Z Sounds like a great way to keep alert, but the video points out that as you consume more caffeine, your brain starts to create more adenosine receptors. VIDEO: What coffee does to your brain 2014-09-02T04:00:00Z It’s time to look at adenosine 2A receptors in the hippocampus. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z During our waking hours, astrocytes continuously release the neurotransmitter adenosine, which builds up in the brain and causes “sleep pressure,” the feeling of sleepiness and its related memory and attention impairments. Why Sleep Deprivation Eases Depression 2013-04-26T11:15:00.723Z When they applied caffeine and recorded from the Kenyon cells, they saw that caffeine acted at adenosine receptors to cause a small depolarization of the Kenyon cells, making them more likely to fire. Plants give bees a caffeine buzz 2013-03-11T13:45:00.377Z Then they measured evidence of an enzyme that is important in metabolism and a chemical called ATP, for adenosine triphosphate. Living Bacteria Found Deep Under Antarctic Ice, Scientists Say 2013-02-06T18:54:17Z These include the adenosine receptor which mediates the effect of caffeine, the opioid receptor which is the target for morphine and the dopamine receptor which binds to dopamine. The GPCR Network: A model for open scientific collaboration 2013-01-16T23:15:02.547Z But the role of adenosine really relies on what receptors it hits, and where those receptors are. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z The neurotransmitter causes this pressure by binding to adenosine receptors on the outside of neurons like a key fitting into a lock. Why Sleep Deprivation Eases Depression 2013-04-26T11:15:00.723Z Caffeine works by blocking adenosine, a molecule that helps us slow down. Viewpoint: Have We Become Too Obsessed with “Energy”? 2013-01-11T12:25:37Z According to the magazine, cells spend the body’s waking hours producing a sleep-promoting chemical called adenosine. Sleep issues, sleep aids, cancer survivor cookbook 2012-10-08T20:27:04Z The selectivity of drug action is due to profound up-regulation of CD73 and adenosine AR expression in neutrophils and inflammatory monocytes as found in recovered cells from the synovial fluid of arthritic mice. [Research Articles] Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis 2012-08-08T18:55:12.537Z The adenosine 2A antagonist, in fact, normalized a lot of messed up things in the stressed rats. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z As more adenosine builds up, more receptors are triggered, and the urge to sleep gets stronger. Why Sleep Deprivation Eases Depression 2013-04-26T11:15:00.723Z Inactivating or inhibiting CD73 attenuates the extracellular formation of adenosine, exacerbating the severity of various inflammatory diseases. [Perspectives] The Outsiders: Emerging Roles of Ectonucleotidases in Inflammation 2012-08-08T18:55:02.027Z Ideally, you should drift off and sleep through the night, burning off the adenosine and waking up refreshed. Sleep issues, sleep aids, cancer survivor cookbook 2012-10-08T20:27:04Z In your brain, caffeine is the quintessential mimic of a neurochemical called adenosine. What Caffeine Really Does to Your Brain 2012-07-27T01:41:18Z What hit me at once about this paper was the phrase “adenosine 2A antagonist”. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z The results confirm that the adenosine buildup is responsible for the antidepressant effects of a lack of sleep. Why Sleep Deprivation Eases Depression 2013-04-26T11:15:00.723Z But our favorite adenosine antagonist has a downside. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z Caffeine increases wakefulness by antagonizing adenosine receptors, and adenosine itself promotes sleepiness. Sleep Deprived? Mind your dopamine. 2012-06-04T16:45:00.263Z The more adenosine in a muscle, the less force it generates. Well Blog: Phys Ed: How Caffeine Can Galvanize Your Workout 2011-12-14T05:01:42Z Caffeine’s interactions with adenosine 2A receptors are much more varied than another antagonist might be. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z Mice with depressivelike symptoms were administered three doses of a compound that triggers adenosine receptors, thus mimicking sleep deprivation. Why Sleep Deprivation Eases Depression 2013-04-26T11:15:00.723Z Instead of acting on neurotransmitters like dopamine or norepinephrine, caffeine acts on adenosine. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z They do hypothesize that adenosine might have something to do with it. Sleep Deprived? Mind your dopamine. 2012-06-04T16:45:00.263Z Instead, Dr. Duncan says, he believes that caffeine “antagonizes adenosine,” a substance in muscles that builds up during exercise and blunts the force of contractions. Well Blog: Phys Ed: How Caffeine Can Galvanize Your Workout 2011-12-14T05:01:42Z In this case, the authors of this study were looking at adenosine 2A receptors. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z This method is believed to work because the short power nap helps clear the brain of the sleep-inducing compound adenosine. Well Blog: Really? The Claim: For a More Restful Nap, Avoid Caffeine 2011-10-31T17:05:20Z High levels of adenosine promote sleepiness, and low levels promote wakefulness. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z Arctic ground squirrels, like all animals and people, produce a molecule called adenosine that slows nerve cell activity. Scientists Induce Hibernation in Squirrels 2011-07-28T14:58:00Z Caffeine reduces adenosine levels, “which then enables more forceful muscular contractions and delays fatigue,” Dr. Duncan says. Well Blog: Phys Ed: How Caffeine Can Galvanize Your Workout 2011-12-14T05:01:42Z There’s a good reason for this, the most well known adenosine 2A antagonist is caffeine! Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z Have arsenate esters replaced phosphate esters to any appreciable extent, for example, in adenosine triphosphate, DNA, RNA, vitamins, phosphoproteins, or phospholipids? [Technical Comment] Comment on ?A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus? 2011-06-02T18:25:19.773Z Caffeine acts on the adenosine receptor as an antagonist, meaning that it blocks the effects of adenosine, promoting wakefulness. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z We devised an experiment in which non-hibernating arctic ground squirrels were given a substance that stimulated adenosine receptors in their brains. Scientists Induce Hibernation in Squirrels 2011-07-28T14:58:00Z An enzyme called ADAR, for instance, induces mismatches in human cells by replacing the base adenosine with another molecule that is then read as guanine when the RNA is used to code for a protein. Genetics: Evidence of altered RNA stirs debate 2011-05-25T17:20:26.963Z The adenosine 2A receptor is playing a role in their anxiety. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z Phosphorus chains form the backbone of DNA and its chemical bonds, particularly in a molecule known as adenosine triphosphate, the principal means by which biological creatures store energy. With Arsenic-Eating Microbe, New Thinking on What Constitutes Life 2010-12-02T17:53:00Z But wakefulness and sleepiness are not all that adenosine does. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z A caffeine molecule is similar enough in structure to adenosine that it binds to the receptors and effectively stops or reverses the onset of drowsiness. Scientists Induce Hibernation in Squirrels 2011-07-28T14:58:00Z All cellular activity is fueled by adenosine triphosphate, or ATP, which resides in each of your cells. Aerobic exercise improves ability to burn fat 2010-09-16T21:31:00Z So it looks like adenosine 2A receptors in the hippocampus are very important in the long term effects of stress. Fighting stress with adenosine antagonists 2013-06-10T16:45:06.980Z The compound adenosine is key to acupuncture's effectiveness, according to a study in Nature Neuroscience. How Acupuncture May Work 2010-05-31T23:18:00Z Adenosine and adenosine receptors have been implicated in things like anxiety disorders. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z Jinka and Drew are expanding their adenosine research to rats, which more closely resemble the physiology of humans. Scientists Induce Hibernation in Squirrels 2011-07-28T14:58:00Z But mice genetically engineered to lack a certain adenosine receptor didn't benefit from the acupuncture session at all—further evidence of adenosine's role. How Acupuncture May Work 2010-05-31T23:18:00Z Blocking enzymes that break down adenosine made the acupuncture much more effective, tripling the level of adenosine near the needle and extending pain relief from about one hour to about three hours. How Acupuncture May Work 2010-05-31T23:18:00Z Levels of adenosine, a neurotransmitter, rose 24-fold in the tissue fluid surrounding the needle. How Acupuncture May Work 2010-05-31T23:18:00Z And of course, if adenosine receptors are there, and caffeine is there, too, you might be getting some effects of caffeine on processing in these areas. Is that guy threatening you? Or is it that extra cup of coffee? 2012-07-23T14:45:03.407Z —Jeremy Singer-Vine How Acupuncture May Work The compound adenosine is key to acupuncture's effectiveness, according to a study in Nature Neuroscience. How Acupuncture May Work 2010-05-31T23:18:00Z Levels of adenosine, a neurotransmitter, rose 24-fold in the tissue fluid surrounding the needle. How Acupuncture May Work 2010-05-31T23:18:00Z |
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