| 单词 | active site |
| 例句 | St. Mark’s, the home of Danspace Project, which is now in its 45th year, is still an active site of worship. Okwui Okpokwasili Wants You to Slow Down and Walk With Her 2020-02-21T05:00:00Z Forest Service stipulates that the observatory must remain an active site for research, astronomy or education — or be dismantled down to its last historic bolt. The battle to save Mt. Wilson Observatory, where we found our place in the universe 2023-10-03T04:00:00Z It was an active site for about three hundred years before being abandoned for reasons unknown. World History: to 1500 2023-04-19T00:00:00Z The active site is where the “action” happens. Concepts of Biology 2013-04-25T00:00:00Z But to adapt these reactions to work with a different subtrate, “you need to remodel the active site dramatically,” says Zanghellini. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z In recent years, Ffos-y-Fran had been the UK's largest and - since the pandemic - its last remaining active site. Merthyr Tydfil: UK's largest opencast coalmine to shut 2023-04-26T04:00:00Z Using the crystal structure of myriocin’s active site as a template, Schulze and his colleagues have developed several molecules that seem to trigger the same benefits without undermining immunity. Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol 2023-03-15T04:00:00Z Some immediately pounced on the suddenly active site. Government Starts Taking Applications for Student Debt Cancellation 2022-10-15T04:00:00Z Since enzymes are proteins, there is a unique combination of amino acid side chains within the active site. Concepts of Biology 2013-04-25T00:00:00Z “We’re starting to see the possibility of really truly creating a complex active site and then building the protein around it,” he says. Proteins Never Seen in Nature Are Designed Using AI to Address Biomedical and Industrial Problems Unsolved by Evolution 2023-04-28T04:00:00Z There are two models that attempt to explain how this active site works. Chemistry 2019-02-14T00:00:00Z The active site is where the “action” happens, so to speak. Biology for AP Courses 2022-06-09T00:00:00Z The first, called inpainting, starts like the previous effort, giving the AI a starting point, such as an active site or another key feature of a desired protein. Dreaming up new proteins, AI churns out possible medicines and vaccines 2022-07-22T04:00:00Z The chemical properties that emerge from the particular arrangement of amino acid R groups within an active site create the perfect environment for an enzyme’s specific substrates to react. Concepts of Biology 2013-04-25T00:00:00Z The substrates bind to a part of the enzyme called the active site. Miller & Levine Biology 2018-01-01T00:00:00Z The most simplistic model is referred to as the lock-and-key hypothesis, which suggests that the molecular shapes of the active site and substrate are complementary, fitting together like a key in a lock. Chemistry 2019-02-14T00:00:00Z However, increasing or decreasing the temperature outside of an optimal range can affect chemical bonds within the active site in such a way that they are less well suited to bind substrates. Biology for AP Courses 2022-06-09T00:00:00Z They then had Rosetta scan a database of protein structures they had previously designed and find an existing scaffold that could possibly hold the active site in the correct shape. Dreaming up new proteins, AI churns out possible medicines and vaccines 2022-07-22T04:00:00Z In some cases of enzyme inhibition, an inhibitor molecule is similar enough to a substrate that it can bind to the active site and simply block the substrate from binding. Concepts of Biology 2013-04-25T00:00:00Z The substrates and the active site may be kept together by weak interactions such as hydrogen bonds and van der Waals forces. Miller & Levine Biology 2018-01-01T00:00:00Z This is not to suggest that an enzyme’s active site is completely malleable, however. Chemistry 2019-02-14T00:00:00Z In some cases of enzyme inhibition, for example, an inhibitor molecule is similar enough to a substrate that it can bind to the active site and simply block the substrate from binding. Biology for AP Courses 2022-06-09T00:00:00Z This characteristic, called specificity, is due to the fact that a substrate with a particular shape and electrical charge can bind only to an active site corresponding to that substrate. Anatomy and Physiology 2013-06-19T00:00:00Z When this happens, the enzyme is inhibited through competitive inhibition, because an inhibitor molecule competes with the substrate for binding to the active site. Concepts of Biology 2013-04-25T00:00:00Z Anything that changes the structure of the protein can change the shape of the active site. Miller & Levine Biology 2018-01-01T00:00:00Z Errors affecting the enzyme's active site that binds to drugs, however, can cripple its ability to break down a drug and subsequently mean there's more of the drug circulating in the blood. Why prescription drugs can work differently for different people 2021-10-10T04:00:00Z On the other hand, in noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than an allosteric site and still manages to block substrate binding to the active site. Biology for AP Courses 2022-06-09T00:00:00Z That can give degraders longer lasting impact and potentially allow them to disable “undruggable” proteins by binding anywhere on the molecule, rather than having to target an active site. Protein-destroying compounds take aim at disease molecules outside cells 2021-08-31T04:00:00Z In contrast, in allosteric activation, the activator molecule modifies the shape of the active site to allow a better fit of the substrate. Concepts of Biology 2013-04-25T00:00:00Z High temperature and very high or low pH can change the active site and cause the enzyme to not work well. Miller & Levine Biology 2018-01-01T00:00:00Z Some drugs block the active site of the liver enzyme cytochrome P450 so it can't be reused, preventing other drugs from binding to it and getting metabolized. Why prescription drugs can work differently for different people 2021-10-10T04:00:00Z In contrast, allosteric activators modify the active site of the enzyme so that the affinity for the substrate increases. Biology for AP Courses 2022-06-09T00:00:00Z The only active site, off Cape Arundel, Maine, was previously closed, then reopened, and will close again after Dec. 31, 2021. EPA approves dredging site off coast of Maine, New Hampshire 2020-09-25T04:00:00Z The unique combination of side chains creates a very specific chemical environment within the active site. Concepts of Biology 2013-04-25T00:00:00Z In these reactions, α-KG binds to the active site of the enzyme to aid catalysis. Tumour metabolites hinder DNA repair 2020-06-02T04:00:00Z But in a major U-turn, Mr. Johnson’s government announced on Saturday that it would temporarily halt fracking in the only active site in Britain, in northwestern England. U.K. Halts Fracking in England, Citing Quake Concerns 2019-11-02T04:00:00Z To keep actin from binding to the active site on myosin, regulatory proteins block the molecular binding sites. Biology for AP Courses 2022-06-09T00:00:00Z In other words, in the presence of the key molecule, that sixth helix pops open, exposing an active site. The ‘dawn’ of designer proteins: Biologists build a protein that turns cells on and off 2019-07-24T04:00:00Z Enzymes have an active site with a unique chemical environment that fits particular chemical reactants for that enzyme, called substrates. Concepts of Biology 2013-04-25T00:00:00Z The park, which borders LACMA, also remains an active site for scientific research, with paleontologists excavating there 361 days a year. Essential California: A new face for the La Brea Tar Pits on a changing Wilshire Boulevard 2019-06-07T04:00:00Z “It was far from the active site of the protein, or it was on the surface,” she said. Frances Arnold Turns Microbes Into Living Factories 2019-05-28T04:00:00Z One part of the enzyme, the active site, interacts with the substrate via the induced fit model of interaction. Biology for AP Courses 2022-06-09T00:00:00Z Burke et al. then used directed evolution to optimize the function of Me-His in the enzyme’s active site. Catalytic machinery of enzymes expanded 2019-05-26T04:00:00Z These methods work by manipulating amino-acid residues involved in the target protein’s mechanism of action, within the active site. An ‘on’ switch for proteins 2019-05-07T04:00:00Z The problem with many of these tough protein targets is that most small-molecule drugs or monoclonal antibodies need to bind to an active site on an enzyme or a receptor to work. Protein-slaying drugs could be the next blockbuster therapies 2019-03-19T04:00:00Z As a second test case, they incorporated DAP into the active site of a cysteine protease enzyme, and showed that the inserted DAP indeed forms an acyl-enzyme intermediate that is resistant to hydrolysis. Enzymes engineered to trap reaction intermediates 2018-12-11T05:00:00Z Sometimes environmental factors, especially low pH and high temperatures, alter the shape of the active site; if the shape cannot be restored, the enzyme denatures. Biology for AP Courses 2022-06-09T00:00:00Z The researchers found that a protein lobe comprising the NELF-A and NELF-C subunits binds near a funnel region in Pol II through which nucleotides normally access the active site. Transcriptional speed bumps revealed in high resolution 2018-08-21T04:00:00Z In other photoactivation methods, a key amino-acid residue in the active site is identified and replaced by a modified version of that residue. An ‘on’ switch for proteins 2019-05-07T04:00:00Z “These pictures don’t prove that there are nuclear weapons in Kaliningrad now, but they do show it is an active site,” Kristensen said. Kaliningrad photos appear to show Russia upgrading nuclear weapons bunker 2018-06-18T04:00:00Z They then used computer modelling to look at how a molecule of PET might dock with the enzyme’s active site—the region where the chemical reaction that breaks down the plastic actually occurs. An enzyme that digests plastic could boost recycling 2018-04-16T04:00:00Z The unique combination of amino acid residues, their positions, sequences, structures, and properties, creates a very specific chemical environment within the active site. Biology for AP Courses 2022-06-09T00:00:00Z Those remaining teams were spread across 170 miles of trail, meaning the finish line will remain an active site for a few more days. Alaska Editorials 2018-02-14T05:00:00Z A region of Bdp1 necessary for transcription initiation that is located within the RNA polymerase III active site cleft. Molecular mechanism of promoter opening by RNA polymerase III 2018-01-16T05:00:00Z Matsubu, J. C., Yang, V. N. & Christopher, P. Isolated metal active site concentration and stability control catalytic CO2 reduction selectivity. Mild oxidation of methane to methanol or acetic acid on supported isolated rhodium catalysts 2017-11-28T05:00:00Z The more-efficient enzyme they engineered appears to hold the plastic molecule more snugly in the active site than the naturally occurring version. An enzyme that digests plastic could boost recycling 2018-04-16T04:00:00Z Another way in which enzymes promote the reaction of their substrates is by creating an optimal environment within the active site for the reaction to occur. Biology for AP Courses 2022-06-09T00:00:00Z The Benjamin Harrison Bridge over the James River near Hopewell is the most active site, with more than 1,000 nests found there this year. Virginia’s cliff swallow population booms 2017-07-12T04:00:00Z But Joshua Pollack, editor of the Nonproliferation Review, was skeptical of the images, saying that they showed an active site — “as they always do.” North Korea might be preparing for another nuclear test, satellite images suggest 2017-03-29T04:00:00Z Clay deposits offer further evidence that Gusev was once an active site. NASA’s Bold Plan to Hunt for Fossils on Mars The message boards at Letsrun.com, the most knowledgeable and active site for running fans, were often full of rants by people who were annoyed by Hall’s religion and dismayed by his failures. Ryan Hall, America’s Fastest Marathoner, Slows Down 2016-01-28T05:00:00Z The chemical properties that emerge from the particular arrangement of amino acid residues within an active site create the perfect environment for an enzyme’s specific substrates to react. Biology for AP Courses 2022-06-09T00:00:00Z The RAS enzymes lack an active site that would normally be the target for a small-molecule drug, says Frank McCormick, who works on RAS at the University of California, San Francisco. Drug development: Mix and match : Nature : Nature Publishing Group 2015-05-12T04:00:00Z If either site fails, the traffic diverts to the remaining active site, giving customers the satisfaction of a continuously available Web presence — even during a major data center outage. Three Emerging Trends Drive CIOs to Be Proactive 2015-03-26T04:00:00Z The structures reveal nine transmembrane helices and an extramembrane cap domain that surround a large central cavity containing the active site. [Report] Structural Insights into Ubiquinone Biosynthesis in Membranes 2014-02-20T19:25:56.572Z That is, as long as your customers are on Facebook too and you’re willing to invest the resources necessary to create and maintain an active site. Why Facebook Is In Decline 2013-08-19T15:09:00Z For example, an enzyme can bind to a specific substrate at a site known as the active site. Biology for AP Courses 2022-06-09T00:00:00Z The green in center represents the active site. Scicurious Guest Writer! X-Ray Crystallography: 100 Years at the Intersection of Physics, Chemistry, and Biology 2012-12-19T17:45:08.617Z The detail afforded might allow medicinal chemists to design molecules that fit precisely into the “active site” of a receptor. Two Americans get chemistry Nobel for elucidating cellular receptors 2012-10-11T01:19:26Z Once bonded, the active site of the enzyme is positioned near the reaction site of the substrate, which it alters to reduce the energy barrier. Enzymes: the little molecules that bake bread 2012-09-28T13:45:00.217Z Because of the importance of the HCV protease, scientists at Vertex and Schering designed small molecules, based on the structure of the protease protein, that could fit into the protease's active site. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z If this active site is altered because of local changes or changes in overall protein structure, the enzyme may be unable to bind to the substrate. Biology for AP Courses 2022-06-09T00:00:00Z The intein, which is a section of a protein, blocks the part of the enzyme that allows the enzyme to do its work, called the active site. Designer Biofuel Crops 2010-04-01T23:00:00Z The location within the enzyme where the substrate binds is called the enzyme’s active site. Biology for AP Courses 2022-06-09T00:00:00Z |
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