| 单词 | xenograft |
| 例句 | This xenograft, as it’s called, would stay in place until the underlying tissue had regenerated enough to supply blood to the skin graft. The 57 Bus 2017-10-17T00:00:00Z Food and Drug Administration requires data showing at least one-year survival of xenografts in nonhuman primates before it will approve clinical studies. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z She injected them into zebrafish embryos, creating xenograft models -- an avatar for each specific patient. Avatars to help tailor glioblastoma therapies 2023-10-04T04:00:00Z “The next big advance in the field is going to be real transplants,” Burlak says, “not the short-term evaluation of xenografts in dead people.” Skin, nerve transplants from genetically modified pigs could help humans, but organs are a way off 2021-10-31T04:00:00Z Melanoma xenografts are unusual in that they engraft and grow fast enough to support the initiation of immunotherapy in patients. Mouse avatars take off as cancer models 2018-10-09T04:00:00Z But in the early 2000s, researchers began to worry that cell-line xenograft models might not be very representative of human cancers. The mice with human tumours: Growing pains for a popular cancer model 2018-08-06T04:00:00Z Prior to the study, xenografts usually survived in nonhuman primates for around three months or less. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z One is that a human immune system will rapidly reject the xenograft. Gene editing may make pigs into organ donors for people 2017-08-09T04:00:00Z The institute is also developing cell cultures and xenografts from tumour cells circulating in the blood, an approach that will allow researchers to model tumours in locations that are difficult for surgeons to biopsy. US cancer institute to overhaul tumour cell lines 2016-02-16T05:00:00Z These defects predict sensitivity to biguanides, antidiabetic drugs that inhibit OXPHOS, when cancer cells are grown in low glucose or as tumour xenografts. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides 2014-04-04T14:06:22.655Z “This is not your dad’s or mom’s xenograft any more,” he says. The mice with human tumours: Growing pains for a popular cancer model 2018-08-06T04:00:00Z The strategy eGenesis has employed for making xenografts last longer is to genetically engineer the pig donor to be more biologically compatible. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z Reduced in vitro and in xenografts resulted in decreased apoptosis and caused antiestrogen resistance. [Research Articles] Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer 2014-03-26T19:25:07.559Z In short, xenograft and many transgenic cancer models fail to model one or more key phases of human cancer. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z The histopathology of these xenografts mimicked the original tumors, and short-term host castration resulted in reduced proliferation and increased apoptosis in tumor cells. [Research Articles] A Preclinical Xenograft Model Identifies Castration-Tolerant Cancer-Repopulating Cells in Localized Prostate Tumors 2013-05-29T19:25:09.490Z G202 produced substantial tumor regression against a panel of human cancer xenografts in vivo at doses that were minimally toxic to the host. [Research Articles] Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy 2012-06-27T18:55:11.413Z It remains to be seen which cluster of gene edits makes for the best xenograft—or even which ones are necessary. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z More importantly, an orthotopic xenograft derived from one of the primary tumours showed no evidence of clonal variation or new coding-region mutations. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z A molecule that doesn't affect xenograft tumours is unlikely to work in patients with multiple myeloma, for example. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z Using human lung cancer xenografts in mice, we confirmed the CMA dependence of cancer cells in vivo. [Research Articles] Chaperone-Mediated Autophagy Is Required for Tumor Growth 2011-11-16T19:55:33.430Z We experimentally validated a prediction for the antiulcer drug cimetidine as a candidate therapeutic in the treatment of lung adenocarcinoma, and demonstrate its efficacy both in vitro and in vivo using mouse xenograft models. [Research Articles] Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data 2011-08-17T20:55:09.200Z Curaxins demonstrated anticancer activity against all tested human tumor xenografts grown in mice. [Research Articles] Curaxins: Anticancer Compounds That Simultaneously Suppress NF-{kappa}B and Activate p53 by Targeting FACT 2011-08-10T20:25:08.997Z We think this possibility is remote because analysis of the early xenografts, which contained contaminating nude mouse DNAs, failed to detect XMRV. [Report] Recombinant Origin of the Retrovirus XMRV 2011-07-05T19:26:24.207Z But myeloma xenografts are generated from lab-grown cell lines, which don't behave much like the primary multiple myeloma cells found in patients' bone marrow. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z Inhibition of CMA delays xenograft tumor growth, reduces the number of cancer metastases, and induces regression of existing human lung cancer xenografts in mice. [Research Articles] Chaperone-Mediated Autophagy Is Required for Tumor Growth 2011-11-16T19:55:33.430Z |
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