| 单词 | variola |
| 例句 | And variola’s genome is so large that it is exceedingly difficult for even experts to assemble. Could chatbots help devise the next pandemic virus? 2023-06-14T04:00:00Z A few years ago, researchers scoured the remains of 1867 people who lived between 30,000 and 150 years ago for genetic traces of variola, the virus that causes smallpox. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z Smallpox is a human virus transmitted by inhalation of the variola virus, localized in the skin, mouth, and throat, which causes a characteristic rash. Biology for AP Courses 2022-06-09T00:00:00Z Monkeypox is a poxvirus in the same family as variola – the virus that causes smallpox – and cowpox viruses and likely evolved in animals before jumping to humans. Dog That Caught Monkeypox Highlights Risk to Pets and Wild Animals 2022-08-18T04:00:00Z The variola virus, which causes smallpox, is the only disease to have been eradicated by human medicine. How 40 years without smallpox vaccinations could make the monkeypox outbreak worse 2022-06-01T04:00:00Z The C.D.C.’s campus in Atlanta is home to one of two Level 4 labs left in the world that harbors the live variola virus, which causes smallpox and was declared eradicated globally in 1980. You Should Be Afraid of the Next ‘Lab Leak’ 2021-11-23T05:00:00Z In the teeth and bones of four Northern Europeans from the Viking era, they found enough DNA to reconstruct entire variola genomes. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z The Centers for Disease Control and Prevention said Thursday that testing showed the vials contain “vaccinia, the virus used in smallpox vaccine” and not the variola virus, which causes smallpox. CDC: Vials contain no trace of virus that causes smallpox 2021-11-19T05:00:00Z Smallpox is a deadly, infectious disease caused by the variola virus that plagued the world for centuries. Daughter of South Dakota governor to quit real estate amid scrutiny 2021-11-17T05:00:00Z Smallpox is a deadly, infectious disease caused by the variola virus that plagued the world for centuries and killed nearly a third of the people it infected. Vials labeled ‘Smallpox’ found in Pennsylvania lab freezer 2021-11-17T05:00:00Z Since it relies on activating the immune response with live smallpox variola virus, inoculation is different from the modern vaccination that eradicated smallpox using the much less harmful but related vaccinia virus. Colonial America was divided over smallpox inoculation, but Benjamin Franklin championed science 2021-07-06T04:00:00Z The sequenced viruses weren’t direct ancestors of the feared variola strain that was eradicated in the second half of the 20th century. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z There are two sites designated by the WHO where stocks of variola virus are stored and used for research: the CDC facility in Atlanta and a center in Russia. CDC: Vials contain no trace of virus that causes smallpox 2021-11-19T05:00:00Z After developing a light fever, the boy soon proved to be immune to variola, the virus that causes smallpox. How Humanity Gave Itself an Extra Life 2021-04-27T04:00:00Z There are two sites designated by the World Health Organization where stocks of variola virus are stored and used for research: the CDC facility in Atlanta and a center in Russia. Vials labeled ‘Smallpox’ found in Pennsylvania lab freezer 2021-11-17T05:00:00Z Smallpox, a deadly infectious disease with symptoms including pus-filled blisters, is caused by the variola virus. Researchers find earliest confirmed case of smallpox 2020-07-23T04:00:00Z Since May, a far less lethal cousin of variola, the monkeypox virus, has been spreading around the globe, giving the virus unprecedented opportunities to change and adapt to the human population. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z Humans as far back as ad 600 carried variola, an international research team reported this week1 after years of fishing for viral DNA in ancient human remains. Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z Virologists had come to believe that variola could survive and replicate only inside human beings. How Humanity Gave Itself an Extra Life 2021-04-27T04:00:00Z The facility in Russia, created in 1974, is one of two places that stores the variola virus, otherwise known as the deadly infectious smallpox disease. Explosion at Russian research lab that stores smallpox virus: officials 2019-09-17T04:00:00Z While the researchers note the 11 individuals were likely infected with the variola virus when they died, it is unclear if it killed them. Researchers find earliest confirmed case of smallpox 2020-07-23T04:00:00Z Based on the 2020 Science paper and his own work on a variola genome from a 17th century child mummy, Poinar believes this happened sometime between the fourth and the 15th century. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z The DNA evidence suggests that diseases such as plague and hepatitis B are associated with major prehistoric migrations — something that seems now to be true of variola too. Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z But because variola had abandoned whatever original host brought it to humans, the virus was uniquely vulnerable to the eradication campaign. How Humanity Gave Itself an Extra Life 2021-04-27T04:00:00Z In 2016, WHO determined the Vector facility "was found to meet international levels of biosafety and biosecurity for variola virus research and storage." Explosion at Russian research lab that stores smallpox virus: officials 2019-09-17T04:00:00Z Despite the existence of a vaccine, federal health officials advise people not to get it unless they live or work in an environment that would put them at risk of contracting the virus, called variola. FDA approves smallpox treatment as part of counterterrorism effort 2018-07-16T04:00:00Z How the loss of genes would have made variola more virulent is not exactly clear, however. Will the monkeypox virus become more dangerous? 2022-09-15T04:00:00Z DNA of the variola virus was found in a person in this Viking-age mass grave in Oxford, UK.Credit: Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z But variola had lost the ability to survive outside human bodies; even our close relatives among the primates are immune. How Humanity Gave Itself an Extra Life 2021-04-27T04:00:00Z Duggan, A. T. et al. 17th century variola virus reveals the recent history of smallpox. Ancient hepatitis B viruses from the Bronze Age to the Medieval period 2018-05-08T04:00:00Z Using an electron microscope, he found what he thought were traces of smallpox, also known as variola virus, in its remains. Mummified child’s remains show signs of a modern scourge 2018-02-09T05:00:00Z Using an electron microscope he found what he thought were traces of smallpox, also known as variola virus, in its remains. A Mummified Child’s Remains Show Signs of a Modern Scourge 2018-01-05T05:00:00Z Four Viking-era individuals provided enough viral DNA for researchers to reconstruct near-complete variola genomes, which they compared with modern variola sequences. Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z Almost half a century ago, it was the site of one of our proudest moments as a species: the elimination of variola major, realizing the dream that Jenner and Jefferson had almost two centuries before. How Humanity Gave Itself an Extra Life 2021-04-27T04:00:00Z That U.S. list of regulated agents includes variola, but not horsepox, because it's not considered a dangerous virus itself. How Canadian researchers built a poxvirus for $100,000 using mail-order DNA 2017-07-06T04:00:00Z The researchers sent samples from a 17th century mummified child to a colleague in Canada, who uncovered remnants of variola virus that causes smallpox, which once ravaged most of the world. The Mummies’ Medical Secrets? They’re Perfectly Preserved 2017-06-02T04:00:00Z The team was also surprised to find that the child mummy’s ancient viral DNA shared many distinct features with modern strains of the variola virus, including several mutations, suggesting they were closely related. Virus found in child mummy suggests recent rise of deadly smallpox 2016-12-08T05:00:00Z Scientists not involved in the variola study are impressed by the work. Smallpox and other viruses plagued humans much earlier than suspected 2020-07-22T04:00:00Z And to the end, he advocated strongly for getting rid of all remaining samples of the variola virus that causes smallpox. Donald Ainslie Henderson (1928-2016) : Nature : Nature Research 2016-10-04T04:00:00Z That made building variola "far more challenging," says Geoffrey Smith of the University of Cambridge in the United Kingdom, who chairs WHO's variola advisory panel. How Canadian researchers built a poxvirus for $100,000 using mail-order DNA 2017-07-06T04:00:00Z “There was no evidence on any remains that would suggest a smallpox infection, so the presence of variola virus was very surprising,” said Ana Duggan, a biologist from McMaster University who worked with Dr. Piombino-Mascali. The Mummies’ Medical Secrets? They’re Perfectly Preserved 2017-06-02T04:00:00Z The sample was rich with variola, the virus that causes smallpox, the team reports today in Current Biology. Virus found in child mummy suggests recent rise of deadly smallpox 2016-12-08T05:00:00Z Smallpox, caused by the variola virus, was long one of mankind’s most terrifying scourges. D.A. Henderson, Doctor Who Helped End Smallpox Scourge, Dies at 87 2016-08-21T04:00:00Z Caused by the variola virus, it was an exceptionally painful and gruesome disease. D.A. Henderson, ‘disease detective’ who eradicated smallpox, dies at 87 2016-08-20T04:00:00Z Producing the variola virus in the same fashion would be prohibited under WHO regulations and rules in place in many nations. How Canadian researchers built a poxvirus for $100,000 using mail-order DNA 2017-07-06T04:00:00Z But by comparing the 17th century strain with modern variola samples, they found the strains shared a common ancestor that emerged between 1530 and 1654. The Mummies’ Medical Secrets? They’re Perfectly Preserved 2017-06-02T04:00:00Z What made it especially embarrassing was that the United States had assured the World Health Organization that the country’s only remaining store of variola was at the Centers for Disease Control and Prevention in Atlanta. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z Just a few days ago, 16 vials labeled "variola", or smallpox, from 1954 were discovered in a storage room by a scientist at the Maryland campus of the National Institutes of Health. Inquiry into US government labs finds flu virus cross-contamination 2014-07-11T04:00:00Z Sixteen vials were labeled “variola,” or smallpox, or were suspected of containing smallpox virus. Smallpox vials, decades old, found in storage room at NIH campus in Bethesda Evans’s experiment may also render moot a long-running debate on whether to destroy the two last known caches of variola. How Canadian researchers built a poxvirus for $100,000 using mail-order DNA 2017-07-06T04:00:00Z NIH and FDA then reported the find to the CDC and the World Health Organization, and on 7 July, CDC employees flew the vials to Atlanta, where researchers confirmed the presence of variola DNA. NIH finds forgotten smallpox store 2014-07-08T04:00:00Z Should all known stocks of variola have been destroyed, rather than preserved at government labs? Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z A scientist discovered six vials labeled “variola,” another name for smallpox, on July 1 in an unused portion of a storage room in the Food and Drug Administration’s laboratory on the NIH campus. Forgotten vial of smallpox found in NIH storage room 2014-07-08T04:00:00Z It was last discussed at the 2011 assembly, which reaffirmed that the stocks of the variola virus should be destroyed but deferred to this year’s meeting discussion on any date of destruction. WHO postpones decision on destruction of smallpox stocks – again : Nature News Blog 2014-05-27T04:00:00Z Yet remnants of variola remain scattered around the world. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z As part of our nation’s biodefense program, cidofovir emerged as one of the best drugs to use in the event of a terrorist attack with the now-eradicated smallpox, or variola virus. Why Everyone Has A Stake In The Chimerix Drug Offered To Josh Hardy (CMX001; Brincidofovir) 2014-03-13T02:26:00Z Before smallpox’s demise, laboratories in many countries kept variola for needed diagnostic and research purposes. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z With nowhere to hide in the natural world—humans are the virus's only host—variola was beaten into extinction. Could Monkeypox Take Over Where Smallpox Left Off? (preview) 2013-03-04T12:15:00.207Z The latter will be important as the destruction of the variola stocks is also a political issue. WHO postpones decision on destruction of smallpox stocks – again : Nature News Blog 2014-05-27T04:00:00Z Molecular virologist Inger Damon, who heads poxvirus research at the CDC, says that the oldest known viable sample of variola is from 1939. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z Typhoid fever may also be complicated with rubeola, pertussis, diphtheria, variola, and vaccinia. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z But regardless of the outcome of the debate, some common-sense precautions are in order for labs that store and handle variola and other dangerous microbes. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z Later known as variola, the virus that caused the disease first attacked the linings of the nose or throat, spreading throughout the body until a characteristic rash followed by virus-filled blisters developed on the skin. Could Monkeypox Take Over Where Smallpox Left Off? (preview) 2013-03-04T12:15:00.207Z Among the Brazilians, who entertain an absolute prejudice against vaccination, the variola is one of the most common and most frightful diseases. Narrative of the Circumnavigation of the Globe by the Austrian Frigate Novara, Volume I (Commodore B. Von Wullerstorf-Urbair,) Undertaken by Order of the Imperial Government in the Years 1857, 1858, & 1859, Under the Immediate Auspices of His I. and R. Highness the Archduke Ferdinand Maximilian, Commander-In-Chief of the Austrian Navy. 2012-01-02T03:00:25.873Z The museum's scab did contain degraded viral DNA, yet it probably belongs not to variola but to a closely related poxvirus. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z If it be so, it appears to the writer to be true in a different meaning of the word self-limitation from that in which it is applied to variola or typhoid fever. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z At a W.H.O. smallpox lab at the University of Birmingham, variola escaped through a ventilation system, infecting a medical photographer, who died. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z On those occasions, we subject our sick patients to vaccination or revaccination; we inoculate the variola in our sheep threatened with the contagion; we pursue the same course in cases of epizootia, of peripneumonia. On the cattle plague: or, Contagious typhus in horned cattle. Its history, origin, description, and treatment 2011-06-24T02:00:18.093Z Its arguments included the risk of stockpiles falling into the wrong hands and that technology existed to create vaccines and anti-viral drugs without access to the live variola virus. WHO defers fixing date on destroying live smallpox 2011-05-25T14:59:31Z The best-preserved body, that of a young woman, had traces of variola DNA in her tissue. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z In the invasion stage of the disease it is often impossible to recognize any symptoms characteristic of variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z In 1979, responding to growing concerns about the potential laboratory hazards of smallpox, California health officials found 12 unrecorded vials of variola. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z The genomes of around 50 strains of the variola virus have also been fully sequenced, and research has already shown that with such a blueprint. Destroy smallpox? 2011-05-16T09:02:30Z Many scientists argue, however, that the variola stocks should be maintained, perhaps indefinitely. World Health Organization to Decide Fate of Smallpox Stocks 2011-05-13T20:15:06.797Z Of more immediate concern is the ease with which someone could synthesize the virus in a clandestine lab: variola's genome sequence has been available since the 1990s. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z Without question, the first papular lesions of variola resemble those of rubeola or measles to an extent which has often deceived the most expert diagnosticians. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The incident renewed calls for all scientists to check the inventories of their freezers and laboratories for variola. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z However the variola virus, which causes the infection, is not gone. Destroy smallpox? 2011-05-16T09:02:30Z The WHO last considered destroying the lab stocks in 2007, when it postponed the decision pending an assessment of whether more research on the live variola virus was needed. World Health Organization to Decide Fate of Smallpox Stocks 2011-05-13T20:15:06.797Z Practically, such a find could reveal just how long the smallpox virus, known as variola, can survive under different conditions. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z PROGNOSIS.—The prognosis of variola is wellnigh inseparably associated with the question of protection by vaccination. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Gradually, the organization strengthened recommendations to limit the number of laboratories authorized to work with variola. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z Smallpox is caused by the variola virus, an ancient pathogen that naturally infects humans and no other species. Should last remaining known smallpox virus die? 2011-03-08T14:52:01Z The variola virus that causes it last swept through humans in a natural outbreak in Somalia in 1977, and the world was declared free of smallpox in 1980. Smallpox should be saved 2011-01-19T18:20:01.280Z For instance, variola could very well be in the freezer of someone who defected from the Soviet Union, says Jahrling. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z When vaccination is practised after the disease is fully developed, the two disorders, vaccinia and variola, apparently concur, and proceed pari passu to the evolution peculiar to each. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The W.H.O. scoured scientific journals to identify all laboratories that had published on variola and then asked them to destroy their stocks, and member countries to verify destruction. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z I have ever considered the variola and the vaccine radically and essentially the same. The Great Events by Famous Historians, Volume 14 The scientific case for retaining live variola virus to improve public health is strong. Smallpox should be saved 2011-01-19T18:20:01.280Z They were able to isolate variola virus for 13 years, when they ran out of scabs, and the experiment has not been repeated. Infectious diseases: Smallpox watch 2014-04-30T17:20:30.360Z Hemorrhagic cases of this severe form are probably more common in variola than in the other fevers, but I have met a notable case in what was diagnosticated scarlatina. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z In the long term, the W.H.O. has said it would destroy the two authorized variola stocks in Atlanta and Siberia. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z In variola, the intensity of the general symptoms, the shot-like beginning of the lesions, their course, the umbilication, and the definite duration, are to be considered. Essentials of Diseases of the Skin Including the Syphilodermata Arranged in the Form of Questions and Answers Prepared Especially for Students of Medicine It received its first important notice from the great Jenner, who confounded it with grease in horses, since animals with this disease are very liable to have the eruption of variola appear on the fetlocks. Special Report on Diseases of the Horse "Truly a plain and simple remedy," remarked the doctor, as he put away his book, "I shall not fail to try it also, if I should ever come across any cases of variola." Angel Agnes The Heroine of the Yellow Fever Plague in Shreveport In confluent variola too, as already intimated, the mucous surfaces suffer proportionately. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Proponents say its destruction would be a natural finish to the eradication program and would prevent terrorists from getting their hands on variola. Ticking Viral Bombs, Left in Boxes 2014-07-14T04:00:00Z It consists of small or large pea-sized, disseminated or grouped, acuminated or rounded pustules, resembling the lesions of acne and variola. Essentials of Diseases of the Skin Including the Syphilodermata Arranged in the Form of Questions and Answers Prepared Especially for Students of Medicine In variola the rosy shallow ulcer and healthy pus, with the acutely tumefied glands, should not be mistaken, at least after a day. Special Report on Diseases of the Horse The view that vaccinia is attenuated variola is well known, and has been extensively adopted by English physicians. Scientific American Supplement, No. 421, January 26, 1884 The expression of an intense variolous poison is known as hemorrhagic variola; also as purpura variolosa and black pox. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Such diseases as hydrophobia, variola, the glanders, cholera, herpes, etc., can be transmitted from animals to man or the reverse; while monkeys are liable to many of the same non-contagious diseases as we are. Darwinism (1889) The most formidable of the early objectors was Dr. Igenhouz, who had come to London to study inoculation for variola, and had already inoculated, among other notable persons, the Archduchess Theresa Elizabeth of Vienna. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 One of the fetuses showed distinct signs of congenital variola, although the mother and other fetus were free from any symptoms of the disease. Anomalies and Curiosities of Medicine I have often observed, that the perspiration or breath of dogs labouring under variola emits a very unpleasant odour. The Dog In the second and much rarer form of hemorrhagic variola there are the usual unfavorable portents of intense prodromic symptoms. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The permanent effects of a particular virus, such as that of the variola, in the constitution, shows that the organic element remembers for the remainder of its life certain modifications it has received. Life and Habit While successful inoculation undoubtedly protected the person from smallpox, sometimes the inoculated form of the disease was virulent, and certainly all cases of inoculated variola were as infectious as the natural variety. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 As for the yellowness like a garment, that is too familiar to the eyes of all who have ever looked on the hideous mask of confluent variola. Medical Essays, 1842-1882 In variola and the vaccine disease the poison is determined to the skin, in glanders to the Schneiderian membrane, and in farcy to the superficial absorbents. The Dog The latter terminated, the period of invasion follows, and extends from the conclusion of the incubative stage to the moment when the first cutaneous lesions of variola appear upon the surface. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z It is quite significant that for certain analogous infectious diseases—e.g. variola and scarlatina—the same frequency of recurrence is not claimed, although as a matter of fact they do occur. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Early in 1797, through another outbreak of cowpox, Jenner was able to inoculate three persons with variola, only to find as before that they were immune from smallpox. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 The contagion is analogous to the contagia which produce splenic fever, measles, scarlatina, variola, etc. 4th. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Pertussis runs a regular course like measles, scarlatina, variola, etc., and rarely attacks a person but once. 8th. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Such is the history in outline of what may be regarded as a typical form of uncomplicated variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Therefore, the term was made applicable to the morbid conditions existing in anthrax, glanders, typhus and typhoid fevers, variola, and also all forms of purulent and putrid infections. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The term variola is from the Latin varus, a pimple. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 The same, however, is true of cholera, typhus fever, scarlatina, variola, and other contagious diseases. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z ETIOLOGY.—Respecting the etiology of variola, it can scarcely be affirmed that our knowledge has been greatly extended since the date of the experiments of Jenner. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Hemorrhagic lesions, isolated or confluent, are seen also in severe forms of variola, not of the two types described above. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z By far the larger number of all transmissions of variola occur after inhalation of the infective medium—in other words, by the avenue of the lungs. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Some authorities conjecture that the virus of variola belongs to the group of filter-passers. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 The invasion stage of variola commonly occupies three days. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z However ill-defined the limits between these classes may be, the symptoms of hemorrhagic variola are sufficiently characteristic to require separate description. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Unquestionably, septa occur in typically developed varicella chambers, similar to those seen in variola—a pathological fact which is the corner-stone of the doctrine relating to the unity of the two disorders. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Aside from the trivial accidents to which the exanthem may be subject, the hemorrhagic types of variola may be regarded as necessarily grave and in a large proportion of cases inevitably fatal. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z In 1788 Jenner had a careful drawing made of the hand of a milkmaid suffering from cowpox to demonstrate to Sir Everard Home how exceedingly similar were vaccinia and variola. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 The symptoms of the class of patients commonly regarded as suffering from varioloid are all those of variola, modified, however, in the direction of a mitigation of their intensity and dangerous character. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The invasion stage of varioloid may be shorter or longer than that occurring in variola vera, and may be insignificant or intensely marked as regards the severity of its symptoms. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z So with the lymph of variola ovina, which Peuch diluted to 1/50 and injected with the effect of producing slight fever and immunity without vesiculation. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z A variation as to the form and contents of the lesion of modified variola occasionally occurs as a consequence of individual peculiarities or of the special surroundings of the patient. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Jenner waited till the nineteenth of the month, and finding that the boy had still not developed variola, he could hardly write for joy. Popular Science Monthly Oct, Nov, Dec, 1915 — Volume 86 DIAGNOSIS.—The establishment of a correct diagnosis where there is question of variola is one of the most critical and important of the duties of a physician. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The absence of marked defervescence is the most characteristic difference between variola in its eruptive stage and typhus, typhoid, and relapsing fevers. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The hyaline degeneration of muscular fibre is found in certain febrile diseases, as typhoid and typhus fevers, scarlatina, variola, and cerebro-spinal meningitis. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z On the other hand, the practitioner should never forget that even apparently desperate cases of variola rally and are won back to life. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The phenomenon termed umbilication, common to the vaccinal pock and to that of variola, has given rise to some differences of opinion as to the mechanism of its production. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z With respect to the propagation of erysipelas from infected to sound individuals, a contrast is exhibited when the transmission of variola, for example, is compared with it. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The cornea, being unmacerated with pus as in severe variola, commonly escapes perforation. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z HISTORY.—The literature of the disease which is now best recognized under the title of varicella has been, in the history of medicine, wellnigh inextricably confused with that of variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z He must learn that diphtheria is, or may be, as dangerous a passenger as variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z Hemorrhagic variola occurs, without question, in different types. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z There is no chronic form of variola lingering for weeks and months after the violence of the fever has abated. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z The anatomy of the exanthematous lesions in hemorrhagic variola is not different from that described above. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z In cases where the eruption is profuse it may be completely generalized, involving largely the trunk and extremities, the lesions, upon the back particularly, being as closely set together as in discrete variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z In all fatal cases of variola the duties of the physician are not ended by the death of the patient. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z It is quite probable, however, that the law of decrease of susceptibility with age holds good for measles as well as for variola, etc., but to a less degree. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z It is particularly to be remarked that the fever does not subside at this time, as is the case in variola. A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases 2012-03-17T02:00:54.097Z |
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