| 单词 | biosynthetic |
| 例句 | Researchers in the Osbourn group at the John Innes Centre have been investigating biosynthetic gene clusters in wheat -- groups of genes that are co-localized on the genome and work together to produce specific molecules. Unexpected discovery opens bioengineering opportunities for human and plant health 2023-11-15T05:00:00Z In 2022, the researchers attracted international attention by programming the longest-ever biosynthetic pathway -- or 'assembly line' -- into a microbial cell factory and designing it to produce biological substances for cancer drugs. Yeast cells can produce drugs for treatment of psychotic disorders 2023-11-10T05:00:00Z However, the biosynthetic pathway of these compounds was so far only known for grasses such as maize. Nature is inventive -- the same substance is produced differently by plants 2023-10-09T04:00:00Z Scientists at the Max Planck Institute for Chemical Ecology in Jena are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z But the team’s approach — using hypotheses about the evolution of biosynthetic pathways to guide the search for ancient life — could reveal more about early life, she adds. Evidence of 1-Billion-Year-Old 'Lost World' of Microbes Discovered Beneath Australian Outback 2023-06-13T04:00:00Z “How is it possible that there is an entire biosynthetic pathway in the human body where if you had to put this in a biochemistry textbook, you would have an empty page?” New human lactation institute aims to fill giant gap in U.S. knowledge 2023-03-30T04:00:00Z Anabolic reactions, or biosynthetic reactions, synthesize larger molecules from smaller constituent parts, using ATP as the energy source for these reactions. Anatomy and Physiology 2013-06-19T00:00:00Z Hence, plants evolved the biosynthetic pathway for the same compounds several times independently. Nature is inventive -- the same substance is produced differently by plants 2023-10-09T04:00:00Z This was the first step in the cardenolide biosynthetic pathway in these two only distantly related plants. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z “But biosynthetic oxygen carriers are still in advanced preclinical development due to the complexities of imitating, rather than just freeze drying, human cells.” Synthetic blood substitute research advances rapidly 2022-04-16T04:00:00Z "The appetite for cannabinoid products is huge and the biosynthetic cannabinoids we will be exclusively using are cleaner, greener, purer, and frankly the future." Beckham-backed cannabis skincare firm to list in London 2021-02-03T05:00:00Z Their biosynthetic pathway is divided into five modules, and several reactions are restricted to membrane-bound organelles. Genetically engineered yeast makes medicinal plant products 2020-09-01T04:00:00Z Meanwhile, their biosynthetic pathway has been described in several grasses, but benzoxazinoids have also been found in other plant species. Nature is inventive -- the same substance is produced differently by plants 2023-10-09T04:00:00Z The Department of Natural Product Biosynthesis at the Max Planck Institute for Chemical Ecology, led by Sarah O'Connor, aims to elucidate the biosynthetic pathways of important phytochemicals with medical relevance. Tracking down the formation of cardenolides in plants 2023-09-18T04:00:00Z Figure 1 | Part of the biosynthetic pathway of colchicine. How the flame lily synthesizes a therapeutic natural product 2020-07-21T04:00:00Z The biosynthetic pathways and enzymes involved in the installation of these sulfo groups were not understood until a few years ago. Enzymes that detoxify marine toxins 2019-06-09T04:00:00Z This biosynthetic strategy requires that the bound product is ultimately released from the final carrier domain, freeing up that domain to conduct additional synthetic cycles. Enzymes engineered to trap reaction intermediates 2018-12-11T05:00:00Z Using genetically mutated bacteria and purified sugar molecules, the authors sought to pinpoint the molecules in the LPS biosynthetic pathway that stimulate NF-κB activation. An immune response with a sweet tooth 2018-08-14T04:00:00Z Above the 3–8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis 2017-11-21T05:00:00Z In bacteria, the genes that encode biosynthetic enzymes for a natural product tend to cluster together in the microorganisms’ genomes11, a fact that aids the identification of these genes in bacteria. How the flame lily synthesizes a therapeutic natural product 2020-07-21T04:00:00Z Antheia is taking it one step at a time, with the short-term goal of bringing a biosynthetic alternative of an existing opioid to market. Therapeutic developments: Masters of medicine : Nature : Nature Research 2017-05-16T04:00:00Z Asterisk above the top panel indicates the approximate position of TSARL1. d, The saponin biosynthetic pathway, showing enzymes that catalyse each step of the pathway and the quinoa gene ID for genes encoding each enzyme. The genome of Chenopodium quinoa : Nature : Nature Research 2017-02-07T05:00:00Z Intracellular bodies composed of purine biosynthetic enzymes exhibit an mTOR-mediated association with mitochondria. Spatial colocalization and functional link of purinosomes with mitochondria | Science 2016-02-11T05:00:00Z That modification enables the carotenoid biosynthetic pathway to produce and accumulate β-carotene in the rice grains. Anti-Golden Rice Activists Want To 'Save The Whales' But Let Children Go Blind 2015-08-05T04:00:00Z The authors also discovered that one of the candidate cytochrome P450 enzymes catalyses two steps in the proposed biosynthetic pathway: the installation of two hydroxyl groups on a benzene ring in an intermediate compound. How the flame lily synthesizes a therapeutic natural product 2020-07-21T04:00:00Z Using an improved version of the algorithm, his team went prospecting in the genomes of almost 2,500 organisms in the human body10, and found more than 14,000 biosynthetic gene clusters. Mining the microbial dark matter 2015-06-15T04:00:00Z Asterisk above the top panel indicates the approximate position of TSARL1. d, The saponin biosynthetic pathway, showing enzymes that catalyse each step of the pathway and the quinoa gene ID for genes encoding each enzyme. The genome of Chenopodium quinoa : Nature : Nature Research 2017-02-07T05:00:00Z Intracellular bodies composed of purine biosynthetic enzymes exhibit an mTOR-mediated association with mitochondria. Spatial colocalization and functional link of purinosomes with mitochondria | Science 2016-02-11T05:00:00Z Next up, Schulz and his team will study how the snow flea produces Sigillin A. The natural product might be made using the snow flea’s biosynthetic machinery. Snow Fleas Pack a Chemical Weapon 2015-05-22T04:00:00Z When these genes were transiently expressed in N. benthamiana with the eight other biosynthetic genes, the total biosynthesis of N-formyldemecolcine was successfully reconstituted. How the flame lily synthesizes a therapeutic natural product 2020-07-21T04:00:00Z The finding means that the complete biosynthetic pathway for the family of compounds that includes codeine and morphine is close to being achieved in yeast. Opiate-making Yeast Could Lead To "Home-brewed Heroin" 2015-05-19T04:00:00Z The early steps in the saponin biosynthetic pathway that are presumably regulated by TSARL1 are shared by other pathways, including sterol biosynthesis. The genome of Chenopodium quinoa : Nature : Nature Research 2017-02-07T05:00:00Z This approach creates libraries of derivatives of natural products by manipulating and mutating these biosynthetic genes. Perspective: Synthetic biology revives antibiotics 2014-04-30T17:21:29.191Z For the other biosynthetic clusters, nested PCR was only conducted once. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z Nevertheless, the final three steps of the biosynthetic pathway, which convert N-formyldemecolcine to the final product, remain unresolved. How the flame lily synthesizes a therapeutic natural product 2020-07-21T04:00:00Z This family of genes is important for abiotic stress response, especially in biosynthetic and detoxification pathways. Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation 2013-04-03T17:22:05.187Z National Academy of Sciences adopted the term “dual use” for instances in which genetic or biosynthetic manipulations create new microorganisms, which, although valuable scientifically, are susceptible to misuse. [Editorial] The Dual-Use Conundrum 2012-09-13T17:55:02.087Z No doubt some of these biosynthetic clusters produce antibiotics, and now they can be found by scanning genomes, instead of screening millions of microbes. Perspective: Synthetic biology revives antibiotics 2014-04-30T17:21:29.191Z However, except for individual biosynthetic pathways reported from environmental sources, the true metabolic potential of these microbes remains unexplored. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z Instead microbes use their remarkable biosynthetic capabilities to synthesize antibiotics and kill the competition. Caves key to fighting superbugs 2012-09-09T23:51:22Z Many isoprenoids are produced in the chloroplast, and a better understanding of their regulation and how best to modify the biosynthetic pathways might allow more biofuel precursors to be produced. Exploiting diversity and synthetic biology for the production of algal biofuels 2012-08-15T17:22:27.080Z Functional-genomics approaches are well suited to identifying the rate-limiting steps in biosynthetic pathways, such as using targeted proteomics to identify two enzymes in the heterologous mevalonate pathway that were poorly expressed. Microbial engineering for the production of advanced biofuels 2012-08-15T17:22:19.783Z Furthermore, transferring biosynthetic gene clusters into other host organisms might accelerate the production of desired compounds. Perspective: Synthetic biology revives antibiotics 2014-04-30T17:21:29.191Z Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. Fungi that steal genes from bacteria 2012-08-12T12:15:00.217Z For instance, the biosynthetic pathways and enzymes that produce cholesterol in humans are very similar to those producing the steroid ergosterol in fungi. Gene duplication frees up enzymes for molecular promiscuity 2012-07-28T11:45:06.120Z If the biosynthetic pathway for the hypothetical arseno-DNA is analogous, we must assume that the arsenic atom fated to replace phosphate originated in the five-position arsenate ester of ribose, the sugar. [Technical Comment] Comment on ?A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus? 2011-06-02T18:25:14.937Z The polyketide biosynthetic pathway is the most versatile for producing hydrocarbons with diverse structures, but it is relatively unexplored for fuels. Microbial engineering for the production of advanced biofuels 2012-08-15T17:22:19.783Z This process provides easy access not only to new antibiotics, but also to new 'parts' — biosynthetic enzymes — for synthetic biology. Perspective: Synthetic biology revives antibiotics 2014-04-30T17:21:29.191Z Synthetic biology often adopts the language of engineers: rather than talking about genes, networks and biosynthetic pathways, practitioners prefer to talk about parts, devices and modules. Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z The two-year preliminary test showed that the biosynthetic corneas restored vision as effectively as cadaver corneas, did not require anti-rejection drugs and allowed normal tears to form. New artificial corneas may restore sight 2010-08-26T03:43:00Z Damaged tissue in one eye was removed, and the new biosynthetic cornea implanted. Restoring sight with new type of artificial cornea 2010-08-25T20:51:00Z The biosynthetic corneas also became sensitive to touch and the treated eyes began producing normal tears, the researchers said. Scientists use synthetic corneas to restore vision 2010-08-25T18:03:00Z The new study, reported Wednesday in the journal Science Translational Medicine, used biosynthetic collagen produced by FibroGen of San Francisco. New artificial corneas may restore sight 2010-08-26T03:43:00Z |
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