| 单词 | tyrosine |
| 例句 | Certain elements of the brain like tyrosine and hydroxytryptophan… instead of being a serotonin inhibitor, which just uses the serotonin you have and Prozac and things like that. Does Prozac help artists be creative? 2013-05-19T06:00:00Z Osimertinib is what scientists call a tyrosine kinase inhibitor, a substance that affects a class of enzymes involved in cell signaling, growth and division. Lung Cancer Pill Halves Risk of Death in Some People 2023-06-08T04:00:00Z This mutation makes the cave fish unable to metabolize the amino acid tyrosine to make the pigment melanin, resulting in their colorless appearance. Blind Cave Fish May Trade Color for Energy 2022-08-25T04:00:00Z Most growth factors bind to cell-surface receptors that are linked to tyrosine kinases. Biology for AP Courses 2022-06-09T00:00:00Z People afflicted with PKU lack sufficient activity of the enzyme phenylalanine hydroxylase and are therefore unable to break down phenylalanine into tyrosine adequately. Anatomy and Physiology 2013-06-19T00:00:00Z Turning Point's lead asset is repotrectiniba that belongs to a class of treatments called tyrosine kinase inhibitors. Bristol Myers to buy Turning Point Therapeutics for $4.1 bln 2022-06-03T04:00:00Z This process is driven by the protein’s IDR — specifically, by tyrosine residues in the sticker region. Chromatin modified in a molecular reaction chamber 2020-03-10T04:00:00Z Each site corresponds to the position of a tyrosine residue known as the acceptor; tyrosine residues that react with acceptors during hormone biosynthesis are called donors. Molecular architecture of the key precursor of thyroid hormones revealed 2020-02-04T05:00:00Z What property enables the residues of the amino acids serine, threonine, and tyrosine to be phosphorylated? Biology for AP Courses 2022-06-09T00:00:00Z Amine hormones are synthesized from the amino acids tryptophan or tyrosine. Anatomy and Physiology 2013-06-19T00:00:00Z The next step is to tailor the rations with nutrients for specific tasks: tyrosine for improved cognition, anthocyanins to repair muscles, calcium to thicken bones. Can Babies Learn to Love Vegetables? 2019-11-18T05:00:00Z NGF does this by binding to tyrosine kinase receptor A, which triggers a cascade of effects that include boosting the number of pain receptors and sensitizing nerves. Analgesia without opioids 2019-09-10T04:00:00Z Each site corresponds to the position of a tyrosine residue known as the acceptor; the tyrosine residues that react with acceptors during hormone biosynthesis are known as donors. Molecular architecture of the key precursor of thyroid hormones revealed 2020-02-04T05:00:00Z First, signaling molecules bind to the extracellular domain of two nearby tyrosine kinase receptors. Biology for AP Courses 2022-06-09T00:00:00Z However, insulin appears to activate a tyrosine kinase receptor, triggering the phosphorylation of many substrates within the cell. Anatomy and Physiology 2013-06-19T00:00:00Z Light clips off the bulky side chain, leaving a normal tyrosine residue that allows substrate binding, thereby activating the protein. An ‘on’ switch for proteins 2019-05-07T04:00:00Z And drugs known as Bruton’s tyrosine kinase inhibitors are emerging: these block a molecule in the signalling pathway that turns some white blood cells cancerous. Lymphoma 2018-11-13T05:00:00Z If this gene, called HPD, is disabled, then no toxic metabolites of tyrosine ever get to where FAH is unable to handle them. CRISPR Cures Inherited Disorder in Mice 2018-10-09T04:00:00Z This molecule disrupts the synthesis of phenylalanine, tyrosine, and tryptophan. Biology for AP Courses 2022-06-09T00:00:00Z In the colloid, peroxidase enzymes link the iodine to the tyrosine amino acids in thyroglobulin to produce two intermediaries: a tyrosine attached to one iodine and a tyrosine attached to two iodines. Anatomy and Physiology 2013-06-19T00:00:00Z Choanoflagellates have genes for tyrosine kinases, enzymes that, in complex animals, help control the functions of specialized cells, such as insulin secretion in the pancreas. The momentous transition to multicellular life may not have been so hard after all 2018-06-28T04:00:00Z At the time PTK7 was what’s called an “orphan receptor tyrosine kinase”—it wasn’t known where it binds in the body. Wanted: More Data, the Dirtier the Better 2017-06-12T04:00:00Z We found frequent alterations of receptor tyrosine kinases and downstream signalling mediators, particularly in EAC. Integrated genomic characterization of oesophageal carcinoma : Nature : Nature Research 2017-01-03T05:00:00Z The amino acid-derived hormones are relatively small molecules derived from the amino acids tyrosine and tryptophan; examples include epinephrine, norepinephrine, thyroxin, and melatonin. Biology for AP Courses 2022-06-09T00:00:00Z Derived from the amino acid tyrosine, they are chemically classified as catecholamines. Anatomy and Physiology 2013-06-19T00:00:00Z The drug belongs to a group of cancer agents called tyrosine kinase inhibitors, which block certain proteins that fuel cancer growth. Cancer Drug Shows Early Promise for Parkinson's Disease 2016-07-12T04:00:00Z Neratinib is a tyrosine kinase inhibitor, which fights cancer by interrupting chemical signals that drive tumor growth. Innovative Trials Produce Promising Breast Cancer Drugs 2016-07-07T04:00:00Z The receptor tyrosine kinase TYRO3 dampens allergic responses and enhances immunity to intestinal worms. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity | Science 2016-03-31T04:00:00Z A peroxidase enzyme then attaches the iodine to the tyrosine amino acid found in thyroglobulin. Biology for AP Courses 2022-06-09T00:00:00Z Other biogenic amines are made from tyrosine, and include dopamine, norepinephrine, and epinephrine. Anatomy and Physiology 2013-06-19T00:00:00Z Moussa is listed as an inventor on a Georgetown University patent application related to the use of tyrosine kinase inhibitors for treating Parkinson's and other neurodegenerative diseases. Cancer Drug Shows Early Promise for Parkinson's Disease 2016-07-12T04:00:00Z Cabozantinib belongs to a different class of drugs, called tyrosine kinase inhibitors, which block chemical messengers needed for cell growth. 2 New Drugs Prove More Effective Against Kidney Cancer, Studies Find 2015-09-25T04:00:00Z The receptor tyrosine kinase TYRO3 dampens allergic responses and enhances immunity to intestinal worms. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity | Science 2016-03-31T04:00:00Z The hormone that triggers the flight-or-fight response, epinephrine, is derived from tyrosine, and the hormone that regulates circadian rhythms, melatonin, is derived from tryptophan. Biology for AP Courses 2022-06-09T00:00:00Z Amine hormones originate from the amino acids tryptophan or tyrosine. Anatomy and Physiology 2013-06-19T00:00:00Z The oncogenic alterations that entrectinib and many similar tyrosine kinase inhibitors target are present in only a tiny subset of cancer patients. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z Chemistry beet One key sticking point has been to identify an enzyme, a tyrosine hydroxylase, that would work in yeast to selectively convert tyrosine to L-DOPA, a key step along the pathway. Opiate-making Yeast Could Lead To "Home-brewed Heroin" 2015-05-19T04:00:00Z Once the two halves of the pathway, from tyrosine to S-reticuline, and from S-reticuline to morphine, are joined together, an appropriately engineered yeast cell will be able to make morphine from sugar. Only connect 2015-05-18T04:00:00Z Phosphorylation of tyrosine residues can either affect the activity of an enzyme or create a binding site that interacts with downstream components in the signaling cascade. Biology for AP Courses 2022-06-09T00:00:00Z That stage turns tyrosine, an amino acid that yeast naturally produces in abundance, into the molecule l-DOPA. Engineered yeast paves way for home-brew heroin 2015-05-17T04:00:00Z The activation of any of these tyrosine kinases, as in cancers with alterations to these genes, is associated with aggressive tumor growth and malignant progression. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z In 2011, researchers in Japan reported that they got the complete first half of the pathway to work in Escherichia coli bacteria, transforming tyrosine to S-reticuline. Researchers closer to engineering yeast that can ferment morphine 2015-05-18T04:00:00Z All the chemicals described here begin with the amino acid tyrosine – nature is crafty in using readily available building blocks to make all manner of chemicals. FDA Accused Of Slacking On Dietary Supplement Dangers 2015-04-11T04:00:00Z The only obvious deficiency seen in yeasts is the complete absence of tyrosine kinases. Biology for AP Courses 2022-06-09T00:00:00Z This reaction converts the amino acid tyrosine into l-DOPA, which can then be converted into dopamine, a compound needed in large quantities for opiate production. Engineered yeast paves way for home-brew heroin 2015-05-17T04:00:00Z The role of tyrosine kinases and their related genetic abnormalities are already well understood. Ignyta, One of ASCO's Biggest Winners, Was A Complete Unknown Three Months Ago 2015-06-09T04:00:00Z The biggest roadblock has been the first step, converting tyrosine into a compound called L-Dopa. Researchers closer to engineering yeast that can ferment morphine 2015-05-18T04:00:00Z Both sprays are patent-pending, and the tyrosine derivative is produced at his father’s Chinese company, which limits the potential for copycats. Need to Come Off a Caffeine High? Try a Spritz of Melatonin 2015-01-22T05:00:00Z It is hypothesized that phosphorylation of tyrosine residues is needed to control the more sophisticated functions of development, differentiation, and cellular communication used in multicellular organisms. Biology for AP Courses 2022-06-09T00:00:00Z This revealed, simply by colour, which mutants most efficiently made l-DOPA from tyrosine but did not make dopaquinone. Engineered yeast paves way for home-brew heroin 2015-05-17T04:00:00Z Figure 4: Inverse relationship between SOX10 and receptor tyrosine kinase expression in melanoma. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z They quickly realized that they could use this enzyme as a color sensor to detect whether any other enzyme was able to convert tyrosine to L-Dopa. Researchers closer to engineering yeast that can ferment morphine 2015-05-18T04:00:00Z It contains water, a derivative of the amino acid tyrosine, and the hormone melatonin, which the human body produces at night to regulate the sleep-wake cycle. Need to Come Off a Caffeine High? Try a Spritz of Melatonin 2015-01-22T05:00:00Z The tyrosine kinases evolved before yeast diverged from other eukaryotes, but the other fifty-five subfamilies of kinases evolved after yeast diverged. Biology for AP Courses 2022-06-09T00:00:00Z The rates of closure are equivalent to the cleavage rates, suggesting that the leaving group tyrosine is protonated simultaneously with loop closure. [Report] Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases 2013-08-22T18:26:23.973Z About ten drugs targeting epigenetic mechanisms are currently in development, but Armstrong predicts that the number may soon rival that of tyrosine kinase inhibitors, by far the most successful class of leukaemia drugs. Epigenetics: Reversible tags 2013-06-26T17:20:55.210Z Going from glucose to tyrosine is easy: Yeast do that naturally. Researchers closer to engineering yeast that can ferment morphine 2015-05-18T04:00:00Z Unlike imatinib and other tyrosine kinase inhibitors, which target particular molecular markers, these epigenetic drugs may be less precise in their action, Armstrong says. Drug development: Target practice 2013-06-26T17:20:53.647Z Which of the following steps takes place before phosphorylation of tyrosine residues? Biology for AP Courses 2022-06-09T00:00:00Z Ponatinib is designed to target an abnormal tyrosine kinase that is closely associated with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia. Ariad drug proves effective in curbing chronic leukemia in study 2012-12-09T13:07:15Z The mantle secretes tyrosine-rich proteins, and oxidation of tyrosine may be essential for shell matrix maturation. The oyster genome reveals stress adaptation and complexity of shell formation 2012-10-03T18:22:26.103Z The group tested an enzyme from sugar beets called a tyrosine hydroxylase. Researchers closer to engineering yeast that can ferment morphine 2015-05-18T04:00:00Z In Science Translational Medicine, two recent studies provide new insight into mechanisms of resistance to ALK tyrosine kinase inhibitors and possible strategies to overcome this resistance. [Perspectives] Escaping ALK Inhibition: Mechanisms of and Strategies to Overcome Resistance 2012-02-08T20:55:04.923Z Fifty-five subfamilies of kinases evolved before yeast diverged from other eukaryotes, but the tyrosine kinases evolved after yeast diverged. Biology for AP Courses 2022-06-09T00:00:00Z Both of these older drugs, respectively known generically as dasatinib and nilotinib, are members of a class called tyrosine kinase inhibitors. Ariad leukemia drug helps 47 percent of patient: study 2011-12-12T00:31:59Z But by the 1990s, at Sugen, he was doing something very different, developing cancer-fighting pills that work by blocking enzymes called tyrosine kinases that cells use to communicate with one another. Serial Lifesaver 2011-09-06T20:05:05Z We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z These pervasive correlations suggest that it is not necessary to assume a unique adaptive mechanism to explain the variation in tyrosine frequencies among these organisms. [Technical Comment] Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:16.067Z All kinases evolved in yeast, but yeast later lost the tyrosine kinases because they do not need them. Biology for AP Courses 2022-06-09T00:00:00Z Ariad's drug is designed to target an abnormal tyrosine kinase that is closely associated with CML and Philadelphia chromosome positive acute lymphoblastic leukemia. Ariad leukemia drug helps 47 percent of patient: study 2011-12-12T00:31:59Z Mastitinib is a tyrosine kinase inhibitor which stops the growth of cancer. UPDATE 1-AB Science wins skin cancer study shortcut 2010-10-05T15:45:00Z Tryptophan is also included for comparison because it is physicochemically similar to phenylalanine and tyrosine. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z Probably driven by natural selection, the metazoan ancestor used the increasing numbers of tyrosine kinases to enhance the evolutionary capability toward the stage of multicellularity. [Technical Comment] Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:16.067Z The evolution of tyrosine kinases involved in cellular communication occurred about 2.5 billion years ago. Biology for AP Courses 2022-06-09T00:00:00Z All three drugs belong to a class called tyrosine kinase inhibitors that target a family of proteins highly active in many types of cancer cells. Sprycel tops Gleevec in newly diagnosed CML: study 2010-06-05T14:39:00Z R788 is the furthest developed in a new class of drugs called oral spleen tyrosine kinase inhibitors being evaluated for rheumatoid arthritis. 2010-02-16T16:54:00Z This phenomenon is minimally influenced by GC force because only T ↔ A substitution is required to directly switch between phenylalanine and tyrosine. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z Hydrolysis by acids indicates that it contains leucine and tyrosine, two amino-acids which are constituents of proteins, along with other bodies of unknown composition. The Chemistry of Plant Life Phosphorylation adds a phosphate group to serine, threonine, and tyrosine residues in a protein, changing their shapes, and activating or inactivating the protein. Biology for AP Courses 2022-06-09T00:00:00Z It is also found in horse’s liver, being one of the putrefaction products of tyrosine. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 6 "Coucy-le-Château" to "Crocodile" Both the tyrosine and tryptophane may be either in the free state or in combination as polypeptid or peptone. The Elements of Bacteriological Technique A Laboratory Guide for Medical, Dental, and Technical Students. Second Edition Rewritten and Enlarged. Thus, constrained substitution of phenylalanine and tryptophan with tyrosine is possibly another mechanism contributing to OTD and supports our observation that there is selection pressure to remove tyrosines for signaling fidelity. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z It is caused by the action of nitric acid on tyrosine. The Chemistry of Plant Life Yeasts are compared because they are the known eukaryotes phylogenetically closest to human that lack a dedicated phosphotyrosine signaling system, and we implicitly assume both species are informative of the ancestral tyrosine frequency. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z We observed that the substitution rate of phenylalanine by tyrosine from yeast to human for pTyr proteins is similar to the rate for human to yeast. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z Phenylalanine and tyrosine are structurally identical except for the hydroxyl group on tyrosine that renders the residue phosphorylatable. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z Furthermore, we uncovered multiple plausible mechanisms acting to reduce tyrosine phosphorylation. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z We then computed the frequency of mutated phenylalanine and tryptophan being substituted with tyrosine from yeast to human and vice versa. [Technical Response] Response to Comment on ?Positive Selection of Tyrosine Loss in Metazoan Evolution? 2011-05-19T18:25:18.573Z |
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