| 单词 | TNF |
| 例句 | Because such drugs, called TNF blockers, suppress the immune system, they invite super bacterial and fungal infections, herpes and rare cancers, the latter especially in children. 6 ways Big Pharma manipulates consumers 2013-04-28T13:00:00Z Attached to "TNF" are Al Michaels and Kirk Herbstreit with Deadline reporting that "Amazon has hired other established talent both in front of and behind the camera." When does "Thursday Night Football" start on Prime Video? 2022-08-25T04:00:00Z The Explore Farther Jacket is available in twilight mauve, silver blue, vanadis grey and TNF black. Black Friday: Hottest coat deals for women 2021-11-26T05:00:00Z “TNF” play-by-play legend Al Michaels spoke for the fan when he critiqued last season’s contests in the streamer’s exclusive NFL package. Former NFL Media journalist Jim Trotter sues league for racial discrimination 2023-09-12T04:00:00Z Among the hundreds of cytokines that exist, tumor necrosis factor, or TNF, stands tall as the most potent and the most studied for nearly the past 50 years. How sepsis can lead to cell death 2023-01-01T05:00:00Z Amazon hasn't announced exactly which TNF games will include Dude Perfect streams just yet. Amazon is teaming up with Dude Perfect for alternate Thursday Night Football streams 2022-08-01T04:00:00Z “I think we’ve put ourselves in a really good position for a strong launch of TNF.” Analysis: Amazon Prime Video gets solid 1st slate from NFL 2022-05-13T04:00:00Z And the Bengals do have extra time to prepare coming off the TNF win, but running back Joe Mixon is nursing an ankle injury. FOX Bet Super 6: NFL Week 5 picks, how to win $100,000 for free 2021-10-07T04:00:00Z Washington has extra time to prepare coming off the TNF win over the Giants. NFL Week 3: Your last chance to win $1,000,000 with FOX Super 6 2021-09-24T04:00:00Z LPS is the strongest known trigger of TNF, which, once on alert, aids in the recruitment of immune cells to the infection site to eliminate invading bacteria. How sepsis can lead to cell death 2023-01-01T05:00:00Z Several targeted therapies focus on a particularly powerful cytokine called tumor necrosis factor, or TNF. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z Looking a total sets of eyeballs, last night’s TNF was up 26% over the second TNF of last season on Fox.” ‘The Seahawks can win the West’: What the national media are saying after Seattle’s wild win vs. Rams 2019-10-04T04:00:00Z Ratings for "TNF" are also said to be 4 percent over where they were this time in the season last year. ‘Thursday Night Football’ ratings hit all-time high for Fox and NFL 2018-11-30T05:00:00Z That brings us to this week's TNF matchup, which is by far the worst of the season, and not just on Thursday night. How to bet the Raiders vs. 49ers game, because that's the ONLY reason to watch it - Golf Digest 2018-11-01T04:00:00Z In normal conditions, TNF promotes beneficial processes such as cell survival and tissue regeneration. How sepsis can lead to cell death 2023-01-01T05:00:00Z Yet clinical trials in multiple sclerosis showed that TNF inhibitors actually exacerbate the disease. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z The “TNF” pregame show will broadcast from Fox News’ cutting edge Studio F and on the outdoor plaza known as Fox Square. Fox News Channel, Fox Sports team up for 'Thursday Night Football' pregame show in New York City 2018-09-26T04:00:00Z "TNF" coverage will continue on December 6 with the Jacksonville Jaguars playing the Tennessee Titans. ‘Thursday Night Football’ ratings hit all-time high for Fox and NFL 2018-11-30T05:00:00Z For conditions such as rheumatoid arthritis, he says, “you only really need to block TNF for a critical 4-to-5-hour window”. Medicine’s secret ingredient — it’s in the timing 2018-04-16T04:00:00Z However, TNF production must be tightly regulated to avoid sustained inflammation and continuous proliferation of immune cells. How sepsis can lead to cell death 2023-01-01T05:00:00Z But anticancer action proved not to be TNF’s main function. The most popular genes in the human genome We can’t know, but given Sherman has been a most vocal critic of TNF, this feels particularly frustrating. Seahawks’ Super Bowl dreams were ruptured along with Richard Sherman’s Achilles 2017-11-09T05:00:00Z The wise play would be to extinguish TNF, as well as Sunday Night Football, and then return Al Michaels and the gold blazer sizzle to Monday Night Football. Who Can Stop the Dreaded Patriots? 2016-10-30T04:00:00Z The pricing pressure may now be hitting another lucrative class: so-called TNF inhibitors, which treat rheumatoid arthritis and other autoimmune diseases. Backlash Against Drug Prices Hits Manufacturers and Middlemen 2016-10-28T04:00:00Z Uncontrolled TNF production can lead to the development of rheumatoid arthritis and similar inflammatory conditions. How sepsis can lead to cell death 2023-01-01T05:00:00Z Therapeutic forms of the TNF protein were highly toxic when tested in people. The most popular genes in the human genome That feed, curated by the company, included tweets with the hashtag #TNF or those that mentioned one of the teams or players. Twitter’s First NFL Broadcast Wins Compliments From Viewers 2016-09-16T04:00:00Z Some other teams will wear all white on “TNF” because their “Color Rush” uniforms are the same color as their opponents, and several others are doing so by choice. NFL's 'Color Rush' uniforms are back, and this time they're color-blind friendly 2016-09-13T04:00:00Z On top of that, their blood levels of TNF and some other inflammatory chemicals declined. Nerve Zap Eased Rheumatoid Arthritis in Small Study 2016-07-12T04:00:00Z In infection conditions, TNF must also be tightly regulated to prevent excessive tissue and organ damage from inflammation and an overactive immune response. How sepsis can lead to cell death 2023-01-01T05:00:00Z Older biologics include brands like Enbrel and Remicade, which target an immune system chemical called TNF. New Psoriasis Drug Works Longer Term, Too 2016-06-08T04:00:00Z Cutting the nerve also blocked the systemic release of TNF after its injection in the brain. Readers Respond to "Electric Cures" 2015-07-04T04:00:00Z But in type 1 diabetes, higher TNF levels appear to lower the attack on the beta cells. New Trial Tests Whether TB Shot Fights Type 1 Diabetes 2015-06-09T04:00:00Z They evaluated the risk of death in more than 2,400 patients and the effectiveness of TNF inhibitor drugs on more than 1,800 patients. Gene Discoveries Could Help Rheumatoid Arthritis Treatment 2015-04-28T04:00:00Z When TNF is left uncontrolled during infections, it can lead to sepsis. How sepsis can lead to cell death 2023-01-01T05:00:00Z While embarking on my imaginary shopping spree, I also recorded every brand name that made an in-stadium appearance, both during the TNF match and in highlights from previous games. How much would it cost to buy everything advertised in an NFL game? 2014-11-13T05:00:00Z But stimulating the vagus nerve also reduced systemic TNF release. Readers Respond to "Electric Cures" 2015-07-04T04:00:00Z Higher levels of TNF cause an increase in the amount of good immune system cells, and lower levels of the bad cells that are responsible for destroying the beta cells, she explained. New Trial Tests Whether TB Shot Fights Type 1 Diabetes 2015-06-09T04:00:00Z But “TNF” is just a money grab, the league creating cheap knockoffs and stamping them with the shield. SNYDER: NFL’s Thursday night money grab does no favors to participants 2014-09-24T04:00:00Z In this model, LPS activates certain immune cells that trigger the production of inflammatory cytokines, in particular TNF. How sepsis can lead to cell death 2023-01-01T05:00:00Z Fortunately, many people with psoriatic arthritis have responded well to the newer biologic therapies that target the molecule TNF alpha. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z After about four years of this contract, with my colleague Junming Le, we’d made an antibody to the cytokine TNF, which was suspected to play a role in sepsis and some autoimmune conditions. A Conversation With Jan Vilcek: Defecting to Great Scientific Success 2013-07-22T19:19:42Z Higher levels of TNF appear to be helpful in certain autoimmune diseases, such as multiple sclerosis, celiac disease and possibly some forms of psoriasis and autoimmune thyroid disease, according to Faustman. New Trial Tests Whether TB Shot Fights Type 1 Diabetes 2015-06-09T04:00:00Z The TNF then binds preferentially to the endothelial cells in a tumour's blood vessels and kills them. Biomedicine: The new gold standard 2013-03-13T18:21:23.433Z Researchers have shown that blocking TNF activity can effectively treat numerous autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. How sepsis can lead to cell death 2023-01-01T05:00:00Z A patient receiving treatment for inflammatory bowel disease with a drug that blocks the activity of TNF- saw her psoriasis dramatically improve. Immunology: A many layered thing 2012-12-19T18:20:51.857Z TNF is difficult to obtain commercially, but the BCG vaccine increases the body's production of it. Human study re-ignites debate over controversial diabetes "cure" 2012-08-08T21:10:49Z Those hamsters returned to a normal light-dark cycle saw both their TNF levels and the density of their dendritic spines return to normal after about two weeks. Late night TV/computer sessions linked to depression 2012-07-24T08:01:38Z Indeed, TNF was once a promising cancer treatment itself, but was dropped because it caused an inflammatory response when delivered systemically — a problem neatly overcome by using the gold nanoparticles. Biomedicine: The new gold standard 2013-03-13T18:21:23.433Z Use of TNF blockers has dramatically increased in the past decades, reaching a market size of roughly $40 billion. How sepsis can lead to cell death 2023-01-01T05:00:00Z Yet despite achieving some encouraging results in animal models of MS, drugs that block the activity of TNF tend not work in patients with MS. Single Genetic Variant Is Linked to Multiple Sclerosis Risk 2012-07-09T20:15:05.273Z Dead autoimmune cells were released into the bloodstream, a hint that TNF was killing them as intended. Human study re-ignites debate over controversial diabetes "cure" 2012-08-08T21:10:49Z The scientists found that blocking the effects of TNF with a drug prevented signs of depression in the hamsters, though some other indicators in the structure of the brain were unaffected. Late night TV/computer sessions linked to depression 2012-07-24T08:01:38Z The normal, long version of the protein sits on the surface of cells and binds the TNF signalling molecule, which is important for a number of processes in the body. Gene flaw link to MS drug failure 2012-07-09T06:37:21Z This is in part because exactly how TNF triggers its toxic effects on the body is still poorly understood despite years of research. How sepsis can lead to cell death 2023-01-01T05:00:00Z Lars Fugger, a neurologist at the University of Oxford, UK, and his team discovered that the variant A shortens the TNF receptor 1 protein. Single Genetic Variant Is Linked to Multiple Sclerosis Risk 2012-07-09T20:15:05.273Z But he believes it may eventually supplant TNF blocker therapy. Takeda drug impresses in ulcerative colitis study 2012-05-22T15:51:57Z "That's why it is very significant that we found this relationship between dim light at night and increased expression of TNF." Late night TV/computer sessions linked to depression 2012-07-24T08:01:38Z But the team discovered the variant caused the production of an altered, shortened version which "mops up" TNF, preventing it from triggering signals - essentially the same thing that TNF blocking drugs do. Gene flaw link to MS drug failure 2012-07-09T06:37:21Z Studying sepsis might provide some clues as to how TNF mediates how the immune system responds to infection. How sepsis can lead to cell death 2023-01-01T05:00:00Z Indeed, two homologous hairpins in TNF and CSF3 correspond to known mRNA-destabilization elements, suggesting roles in mRNA stability for the two families. A high-resolution map of human evolutionary constraint using 29 mammals 2011-10-26T17:21:43.610Z Vedolizumab, which is given intravenously, belongs to a different class of biologic drugs than the TNF blockers widely used to treat colitis and other inflammatory diseases, such as Johnson & Johnson's Remicade and Abbott Laboratories' Humira. Takeda drug impresses in ulcerative colitis study 2012-05-22T15:51:57Z The key player in the diabetes study is a protein of the immune system called tumor necrosis factor, or TNF. Vaccine shows promise in reversing Type 1 diabetes 2011-06-26T01:12:51Z In Yvon’s case this is a CSR effort, but Douglas sold his interests in TNF long ago and is using that personal wealth for public gain. Nike's Global Design Director On Limestone Wetsuits And Sustainability 2011-06-24T22:48:45Z In acute inflammatory conditions such as sepsis, TNF blockers are less able to address TNF overproduction. How sepsis can lead to cell death 2023-01-01T05:00:00Z The drug blocks action of tumor necrosis factor, or TNF, which is linked to inflammation. Abbott Wins Bid to Reverse J&J $1.67 Billion Patent Win 2011-02-23T16:41:08Z The findings, published in the journal Arthritis & Rheumatism, raise the possibility that obese patients are less likely to see results with infliximab or other drugs in the same class, known as TNF blockers. Arthritis drug less effective for obese patients 2010-11-18T22:20:00Z Studies by others have shown that if you increase levels of TNF in the blood, it will block other parts of the immune system that attack the body, especially the pancreas. Vaccine shows promise in reversing Type 1 diabetes 2011-06-26T01:12:51Z These drugs work by blocking an inflammatory protein known as a tumor necrosis factor, or TNF. 2010-02-16T16:54:00Z However, studies in mice show that neutralizing TNF can prevent the death of the animal from bacterial LPS. How sepsis can lead to cell death 2023-01-01T05:00:00Z Blood cells made in the bone marrow, or myeloid cells, are known to be the major producers of TNF. How sepsis can lead to cell death 2023-01-01T05:00:00Z TNF blockers are part of a group of relatively newer drugs known as biologic response modifiers, which are all designed to act on the immune system to help slow arthritis progression. Arthritis drug less effective for obese patients 2010-11-18T22:20:00Z When we injected a lethal dose of TNF in mice lacking the two proteins in two specific types of myeloid cells, neutrophils and macrophages, mice had reduced symptoms of sepsis and improved survival. How sepsis can lead to cell death 2023-01-01T05:00:00Z According to Tak's team, the study appears to be the first to look at how body weight might affect the response to TNF blockers, in patients with any autoimmune disease. Arthritis drug less effective for obese patients 2010-11-18T22:20:00Z Although researchers do not yet understand the reason for this discrepancy, it highlights the need for further understanding how TNF contributes to sepsis. How sepsis can lead to cell death 2023-01-01T05:00:00Z For patients and doctors, he added, they serve as an alert that TNF blockers might be relatively less effective for obese people. Arthritis drug less effective for obese patients 2010-11-18T22:20:00Z |
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