单词 | thalidomide |
例句 | As the editor of The Sunday Times in the ’70s, he forced an international reckoning with Big Pharma, taking on drugmakers who played down the substantial health risks of the tranquilizer thalidomide. Harry Evans, Potentate of Print, Was Also a Social Butterfly 2020-09-28T04:00:00Z Sunday Times published some memorable journalism; none more so than its determination to win compensation for the victims of thalidomide. Per ardua ad Astor 2016-02-25T05:00:00Z But then: "Here she is at her kitchen table, fingering a jigsaw of thalidomide ginger, thinking about the arthritis in her hands." Heartbreak by Craig Raine 2010-07-04T11:43:00Z In the poem, Plath connects her experience with the fears of a pregnant woman taking thalidomide. How Sylvia Plath’s secret miscarriage transforms our understanding of her poetry 2022-03-08T05:00:00Z Not that its award-winning German director, Niko von Glasow — who was exposed prenatally to thalidomide — was particularly eager to cajole 11 of his peers into joining him in baring all for a nude calendar. | 'NoBody?s Perfect': The Devastating Legacy of Thalidomide 2010-04-16T00:54:00Z The drug thalidomide was licensed in the 1950s to help expectant mothers deal with morning sickness. Five documentaries to watch in 2014 2014-06-06T04:00:00Z The prosthetic limbs mass-produced by the British government in response to the thalidomide crisis in the 1960s aimed chiefly to look like realistic limbs, and yet they were clunky and rather macabre. Superhuman: are we the greatest design project of the century? 2012-07-17T12:38:33Z The dangers became even more apparent during the thalidomide tragedy of the 1960s. The battle for medicine’s soul: A century of alternative remedies 2014-01-19T19:00:00Z He was one of several students named Harvey — the name’s trendiness being one of the “three greatest mistakes of the ’50s,” he jokes, along with Formica and thalidomide — but always stood out in a crowd. Harvey Fierstein Sings the Song of Himself in ‘I Was Better Last Night’ 2022-02-28T05:00:00Z Mr. Quasthoff, now 55, was born with severe physical deformities owing to his mother’s use of thalidomide during a difficult pregnancy. Celebrated Bass-Baritone Plans a Surprise Debut at Conducting 2015-07-22T04:00:00Z Rare enough to make “NoBody’s Perfect” an exemplar of fresh-air filmmaking that addresses the devastating legacy of the drug thalidomide with acidic wit and grumpy honesty. | 'NoBody?s Perfect': The Devastating Legacy of Thalidomide 2010-04-16T00:54:00Z There is no evidence Plath ever took thalidomide, a drug developed in 1954 prescribed to treat several symptoms including nausea and anxiety in pregnant women. How Sylvia Plath’s secret miscarriage transforms our understanding of her poetry 2022-03-08T05:00:00Z I remember playing On Giant's Shoulders about that lovely thalidomide boy Terry Wiles. Judi Dench: 'I never want to stop working' 2012-10-13T23:05:47Z "The thalidomide tragedy is a dark chapter in the history of our nation and the world," Albanese said in a statement. Australia to apologise half a century after 'Thalidomide tragedy' 2023-11-13T05:00:00Z Some of that mistrust may be rooted in the 1950s and '60s, when the morning sickness drug thalidomide led to thousands of babies being born with severe birth defects. Why people who experience severe nausea during pregnancy often go untreated 2023-01-18T05:00:00Z They are among thousands born with limb deformities after their mothers took thalidomide while pregnant. Thalidomide survivors in Scotland to get lifelong support 2022-07-04T04:00:00Z One was the morning sickness drug thalidomide, tested on American women in the 1950s, that could cause severe birth defects or stillbirths. The New Abortion Bans: Almost No Exceptions for Rape, Incest or Health 2022-06-09T04:00:00Z As Mr. Zaritsky told it, he was especially drawn to stories of people who might otherwise be overlooked or forgotten, including victims of the drug thalidomide. John Zaritsky, Oscar-winning documentarian, dies at 78 2022-04-19T04:00:00Z “We don’t want another thalidomide,” Faden says, referring to the drug developed by a West German company in the 1950s. Which medicines can you take when pregnant? New efforts aim to crack a scientific black box 2022-03-16T04:00:00Z Or maybe there was a disproportionate increase in the use of thalidomide? COVID-19 science or blind compliance 2022-01-30T05:00:00Z Jean, 61, who was born with damage to all four of her limbs as a result of thalidomide, welcomed the announcement. Thalidomide survivors in Scotland to get lifelong support 2022-07-04T04:00:00Z Mr. Evans, the historian Simon Schama recalled, had been a “hot-metal journalist” who had overcome British legal restrictions to expose the ravages of the drug thalidomide in the 1970s. A Comedy Nails the Media Apocalypse 2021-12-12T05:00:00Z This research approach stems from the thalidomide scare of the early 1960s when children exposed to the drug in utero were born with severe birth defects. Why only one-third of pregnant women are vaccinated against COVID-19, and what they should know 2021-11-09T05:00:00Z It stems in part from the tragedy that followed the prescribing of a sedative, thalidomide, to treat morning sickness in pregnant women in countries around the world during the 1950s. Young, pregnant and unvaccinated: Hospitals confront a wave of severe illness and death 2021-10-07T04:00:00Z Having both can lead to disastrous effects; in the 1950s and 1960s, one mirror image of the molecule thalidomide caused severe birth defects in thousands of babies. Nobel Prize in Chemistry Awarded to Scientists for Tool That Builds Better Catalysts 2021-10-06T04:00:00Z Scotland played a leading role in dealing with the impact of thalidomide in the past. Thalidomide survivors in Scotland to get lifelong support 2022-07-04T04:00:00Z The drug thalidomide, for example, which was developed in the 1950s, was manufactured with both “left-handed” and “right-handed” compounds — one performed very well in reducing morning sickness in pregnant women; the other caused birth deformities. Nobel Prize in chemistry awarded to duo who made a tool to build molecules in an environmentally friendly way 2021-10-06T04:00:00Z A few already approved drugs, such as thalidomide, have turned out to work the same way. Protein-destroying compounds take aim at disease molecules outside cells 2021-08-31T04:00:00Z Although it was not approved by the Food and Drug Administration, thalidomide was given to Americans in trials. Young, pregnant and unvaccinated: Hospitals confront a wave of severe illness and death 2021-10-07T04:00:00Z We had thalidomide, we had DES, we had Dalkon Shield because of unregulated things. Why it's so hard to talk about 'down there': The doctor who is normalizing menopause 2021-06-10T04:00:00Z Though vaccines are quite different from powerful drugs like thalidomide, most health services are erring on the side of caution. Covid: No evidence that vaccinations harm fertility 2021-02-12T05:00:00Z Let’s turn to noted scientific historian Billy Joel, and the “children of thalidomide.” Why the FDA is taking 22 days to look over J&J’s data 2021-02-06T05:00:00Z Evans “fought for compensation for the victims of thalidomide, a morning-sickness drug that killed thousands of babies in the womb and caused severe birth defects before being taken off the market in 1961.” Opinion | Readers critique The Post: Bijan Ghaisar’s name belongs with George Floyd’s and Breonna Taylor’s 2020-10-09T04:00:00Z Beginning in 1957, another drug, thalidomide, was distributed to thousands of pregnant women around the world as a remedy for morning sickness. Why are so few drugs tested for safety in pregnancy? 2020-10-05T04:00:00Z What many called his greatest triumph arose in an inquiry into the tranquilizer thalidomide, which caused severe deformities in thousands of babies and led to lawsuits against a drugmaker. Harold Evans Dies at 92; Crusading Newspaperman With a Second Act 2020-09-24T04:00:00Z The episode was considered Mr. Evans’s greatest triumph, a dual victory for both thalidomide survivors and press freedom. Harold Evans, crusading editor on both sides of the Atlantic, dies at 92 2020-09-24T04:00:00Z His most famous campaign – for the victims of the thalidomide drug, taken by pregnant women and which led to birth deformities in thousands of babies – became a preoccupation for decades. Harold Evans taught us what journalism at its best can achieve | Alan Rusbridger 2020-09-24T04:00:00Z His Insight Team of investigative journalists exposes the plight of British children who suffered birth defects from thalidomide, leading to compensation for the families and a landmark legal reform lowering barriers to reporting on lawsuits. Timeline: The career of Sir Harold Evans, journalist, publisher and author 2020-09-24T04:00:00Z Britain’s laws on contempt of court barred coverage of ongoing civil lawsuits, including the one brought by thalidomide families against Distillers, the manufacturer. Column: The insights of Harold Evans, a journalist of tenacity 2020-09-24T04:00:00Z One of his most famous investigations exposed the plight of hundreds of British thalidomide children who had never received any compensation for their birth defects. Sir Harold Evans, trail-blazing newspaper editor, dies aged 92 2020-09-24T04:00:00Z By all accounts, Thomson gave Mr. Evans a free hand in publishing sensitive stories, including the series on thalidomide. Harold Evans, crusading editor on both sides of the Atlantic, dies at 92 2020-09-24T04:00:00Z For example, thalidomide was released in the 1950s, marketed as a “miracle drug” for morning sickness. The Failure of Public Health Messaging about COVID-19 2020-09-05T04:00:00Z But Califano sees a sign that his search for cancer linchpins will pay off in an unlikely cancer success story: thalidomide. Computer algorithms find tumors’ molecular weak spots 2020-06-11T04:00:00Z To nail the thalidomide story, Evans used a tactic common then on Fleet Street, reaching for the cheque book to pay a source £8,000 for key documents. Column: The insights of Harold Evans, a journalist of tenacity 2020-09-24T04:00:00Z It was a friend and fellow thalidomide survivor, Berrisford, who first alerted me and other members of our community to the added dangers posed by coronavirus. The coronavirus conundrum when your mouth is your ‘hand’ 2020-05-28T04:00:00Z Mr. Abe himself noted in a news conference on Monday that the side effect was “the same as thalidomide,” which caused deformities in thousands of babies in the 1950s and ’60s. This Drug May Cause Birth Defects. Japan’s Pushing It for Coronavirus. 2020-05-05T04:00:00Z In 1998, the company received approval from the Food and Drug Administration to bring back thalidomide as a treatment for leprosy — and, possibly, as a treatment for AIDS. Column: Here's why a COVID-19 vaccine could end up costing you a small fortune 2020-04-21T04:00:00Z Some recalled that in the 1950s inadequate testing of thalidomide caused thousands of children to be born with malformed limbs. The Coronavirus in America: The Year Ahead 2020-04-18T04:00:00Z And it fought for years and won justice against a corporation, Distillers, on behalf of the children disabled by the company’s drug, thalidomide. Column: The insights of Harold Evans, a journalist of tenacity 2020-09-24T04:00:00Z She is one of a handful of babies whose parents sued her mother’s doctor, Dr. Ray O. Nulsen, as well as Richardson-Merrell, the company that ran a large trial of thalidomide in the United States. Thalidomide Use Did Happen Here, These Americans Say 2020-03-23T04:00:00Z By September 1962, investigators were beginning to conclude that, even by the laxer standards of the day, Richardson-Merrell had illegally promoted thalidomide before it had been approved. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z Then the company realized a modified form of thalidomide had potential as a treatment for blood cancer. Column: Here's why a COVID-19 vaccine could end up costing you a small fortune 2020-04-21T04:00:00Z Angered by her poor job prospects, she consulted a lawyer to look into the thalidomide story. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z In the case of thalidomide, that meant, as his assistant recalled, writing personal letters enclosing an article to every one of Britain’s 600-plus members of parliament. Column: The insights of Harold Evans, a journalist of tenacity 2020-09-24T04:00:00Z “There needs to be some type of compensation for all of the victims. Like in the other countries where the thalidomide survivors are asking for apologies from the government, I think we need that here.” Thalidomide Use Did Happen Here, These Americans Say 2020-03-23T04:00:00Z Overseas, thousands of babies in Germany, England and other countries were being born with severe defects tied to their mothers’ use of thalidomide, a drug widely taken for insomnia, morning sickness and other ailments. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z Researchers later found that thalidomide caused irreversible birth defects, with thousands of children born with severe malformations and many not surviving more than a few days. Column: Here's why a COVID-19 vaccine could end up costing you a small fortune 2020-04-21T04:00:00Z Her lawyer sent them to a lab, but the tests could not determine whether they were thalidomide, and they were not returned. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Over nine seasons — eight of which are currently available to stream — it has never shied from social realism, featuring storylines about illegal abortions, thalidomide babies and domestic abuse. The 44 best TV shows to binge while self-quarantining, according to TV experts 2020-03-18T04:00:00Z Grunenthal synthesized tramadol in the 1960s, as the company was embroiled in scandal over its marketing of the sedative thalidomide, which caused extreme birth defects in thousands of babies whose mothers took it. `'Safer opioid’ has sparked a crisis in vulnerable countries 2019-12-13T05:00:00Z Others denied they had given out thalidomide, or refused to talk. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z A company spokeswoman told me that “Revlimid is structurally, functionally and pharmacologically different than thalidomide, and the two drugs have different clinical, safety and toxicology profiles.” Column: Here's why a COVID-19 vaccine could end up costing you a small fortune 2020-04-21T04:00:00Z Soon, Grünenthal and its overseas partners were selling thalidomide for a range of ailments, including morning sickness in pregnant women. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z He was born without arms, after his mother was prescribed the drug thalidomide during her pregnancy, which was later found to cause birth defects. What Painting With Your Feet Does to Your Brain 2019-09-10T04:00:00Z Dr. Mishka Terplan, a member of the American College of Obstetricians and Gynecologists’ addiction expert group, said that for years, the thalidomide scare “shut down all research of medications in pregnancy.” Is pot safe when pregnant? Study seeks answer, draws critics 2019-08-07T04:00:00Z But that September — while the F.D.A. investigation was well underway — the company was still defending thalidomide’s reputation to American physicians. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z And there is a long history around the world of doctors giving their approval to innovations – cigarettes, certain levels of radiation, thalidomide, mercury – that turn out to be anything but safe. Why we are addicted to conspiracy theories 2019-05-02T04:00:00Z F.D.A. officials later noted that prosecutors had made a critical error when they said only one baby had been born in the United States with defects from thalidomide. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The Australian government was warned about thalidomide in December 1961 by the drug's distributor, Distillers. How Australia has 'lagged' on thalidomide response 2019-04-02T04:00:00Z Food and Drug Administration never approved thalidomide for morning sickness because of safety concerns. Is pot safe when pregnant? Study seeks answer, draws critics 2019-08-07T04:00:00Z Although the names are redacted, the text is revealing: In one case, a doctor had been using thalidomide himself and prescribing it to his wife. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z Handa had been trying to understand why the infamous drug thalidomide, approved in some countries in the late 1950s and early 1960s to help with nausea in pregnancy, caused problems with limb development. Protein-slaying drugs could be the next blockbuster therapies 2019-03-19T04:00:00Z This would mean thalidomide survivors could have a wider range of defects. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Celgene resurrected the infamous drug thalidomide as a successful treatment for cancer — and increased its price by a factor of 100 in the process. Daily briefing: Why more people die when the economy prospers 2019-01-22T05:00:00Z Among the most tragic examples is thalidomide, a drug developed in Germany in the 1950s as a sedative. Is pot safe when pregnant? Study seeks answer, draws critics 2019-08-07T04:00:00Z In addition to the wife’s loss of vision, the doctor mentioned peripheral neuritis, nerve pain that is a side effect of thalidomide. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z "It's a culture that stems from thalidomide," she says. 'I was devastated my husband chose to die' 2018-11-21T05:00:00Z With the lawsuits in tatters, those who considered themselves the American survivors of thalidomide met on a late winter weekend in 2018 at a Holiday Inn near the Atlanta airport. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z “Perhaps more than for any other available drug, the need to provide and distribute thalidomide responsibly is essential to the public health,” the agency wrote in the letter. A G.O.P. Senate Candidate Highlights His Drug Industry Career. Should He? 2018-09-24T04:00:00Z But at the time she was told that thalidomide wasn’t available in the United States, although other sources cite the dispersal of 2.5 million tablets in the U.S. for clinical trials. Man with only 1 arm, 3 fingers living independent life 2018-01-13T05:00:00Z Just days earlier, the F.D.A. had instructed its inspectors to interview every doctor who had received thalidomide and to investigate if any babies were harmed. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z One such case was when German company Chemie Grunenthal developed thalidomide, a drug given to pregnant women to treat morning sickness. Uni scientists' drugs breakthrough 2018-01-05T05:00:00Z Around the world, thalidomide survivors have been making a renewed push for recogition. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Thalomid was Celgene’s brand name for thalidomide, an old drug that became notorious in the 1960s after it was traced to thousands of birth defects worldwide. A G.O.P. Senate Candidate Highlights His Drug Industry Career. Should He? 2018-09-24T04:00:00Z Thalomid, another name for thalidomide, a drug prescribed for morning sickness in the 1950s and 1960s that caused severe birth defects, was approved by the agency in 1998 for treating leprosy. Pharmaceutical company Celgene settles suit for $280 million 2017-07-26T04:00:00Z The F.D.A. began to jettison cases that did not help it build a case against Richardson-Merrell, even when there was evidence that thalidomide had harmed a child. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z In the 1960s, following discoveries that the drug caused horrific birth defects, thalidomide was pulled from pharmacy shelves worldwide. Celgene to Pay $280 Million to Settle Fraud Suit Over Cancer Drugs 2017-07-25T04:00:00Z Historians say the lesson of thalidomide is one that society is still learning the hard way. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Will this revolutionary drug be the new thalidomide, creating a new generation of children who experience devastating side effects because doctors get too excited too quickly? The Ketamine Breakthrough for Suicidal Children 2017-07-18T04:00:00Z Because Congress was in a rush to respond to the thalidomide tragedy in the early 1960s, when the babies of some women who took the morning-sickness drug were left with permanent birth defects. Opinion | Gruesome tales from a dysfunctional health care system 2017-05-19T04:00:00Z In the report above, the F.D.A. concluded that the child had been harmed by thalidomide prescribed by a doctor who had participated in Richardson-Merrell’s clinical trial. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z He said lawmakers must learn from the history of thalidomide, a German drug prescribed for morning sickness that resulted in serious, often fatal, birth defects. Nebraska lawmakers consider allowing medical marijuana 2017-04-19T04:00:00Z By the time the man on the bus asked about thalidomide, Carolyn’s parents were divorcing. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The iconic example is the more than 10,000 birth defects caused worldwide by the drug thalidomide, a late 1950s remedy for nausea during pregnancy. Show drugs work before selling them 2017-03-07T05:00:00Z Congress toughened the drug approval process in the wake of the worldwide crisis over thalidomide, which caused severe birth defects in babies whose mothers had taken the drug in pregnancy. Trump’s F.D.A. Pick Could Undo Decades of Drug Safeguards 2017-02-05T05:00:00Z Today, many Americans who believe their defects were caused by thalidomide have no definitive proof. The Story of Thalidomide in the U.S., Told Through Documents 2020-03-23T04:00:00Z It took the famous thalidomide scandal to establish, over industry objection, that drug approval would require “substantial evidence with effective data from adequate and well-controlled clinical trials.” Big Pharma-backed bill won’t cure the FDA 2016-11-18T05:00:00Z Her Google search led her to a Facebook group for international survivors of thalidomide, and she learned there that a lawsuit was being prepared on behalf of American victims. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z But just when he was finishing tramadol’s development, Grünenthal was overtaken by a crisis: Its popular drug thalidomide was causing catastrophic birth defects. Tramadol: The Opioid Crisis for the Rest of the World 2016-10-19T04:00:00Z One notorious example is thalidomide, a drug developed in the 1950s for treating morning sickness in pregnant women. The new breed of cutting-edge catalysts 2016-09-05T04:00:00Z Eden quickly had surgery and eventually entered a clinical study involving pomalidomide, a thalidomide derivative that is thought to interfere with tumor growth. For a 6-year-old with cancer, a future staked on medicine’s hottest field 2016-09-01T04:00:00Z Concern about ad regulation intensified in the 1960s, after a rash of birth defects caused by thalidomide. How lawyers scare people out of taking their meds 2016-08-05T04:00:00Z In the United States, thalidomide was never approved for sale because a drug reviewer at the F.D.A., The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z More wrenching, babies begin to be born with malformed bodies, poisoned by the experimental drug thalidomide. “Call the Midwife,” a Primal Procedural 2016-06-13T04:00:00Z Angus Dalgleish, a professor of oncology at St George’s hospital in Tooting, London, became interested in the drug after witnessing the dramatic turnaround of a patient with autoimmune disease who was treated with thalidomide. The cancer drugs in your bathroom cabinet 2016-06-12T04:00:00Z Sometimes it is down to editorial tenacity, as at the Sunday Times over thalidomide, the Times over Rotherham and the Daily Mail over Stephen Lawrence. From Snowden to Panama, all hail the power of the press | Simon Jenkins 2016-04-06T04:00:00Z During that decade, thousands of children were born with malformed limbs after their mothers were prescribed thalidomide, which had been marketed as a mild sleeping pill. U.S. details 9 Zika pregnancies: 2 abortions, 2 miscarriages, 1 baby with ‘severe microcephaly’ 2016-02-26T05:00:00Z In November 1961, Grünenthal announced it was pulling thalidomide from the German market because of questions about whether the drug was causing birth defects. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Within a year it became clear that the drug — known generically as thalidomide — was a horror: Thousands of babies around the world had been born with bodily defects, typically flipperlike arms and legs. In 2015 Obituaries, a Portrait of Eras Grim and Innocent 2015-12-29T05:00:00Z At around the same time, the results of a small trial of thalidomide in patients with the bone marrow cancer myeloma were published. The cancer drugs in your bathroom cabinet 2016-06-12T04:00:00Z In the early 1960s, a German measles epidemic and the introduction of thalidomide, both of which caused severe fetal deformities, spurred an increase in therapeutic abortions. The right’s destructive anti-choice propaganda war: Why it’s time to fight back & how we can do it 2015-12-01T05:00:00Z They also worried that experimental treatments might harm pregnant women or their babies, especially after the 1960s, when the morning sickness drug thalidomide was found to cause birth defects. Can Female Mice Improve Autism Research? 2015-10-20T04:00:00Z It posits that thalidomide could have interfered with embryonic growth in many ways, including stopping the creation of blood vessels, which halted the formation of limbs. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Canada and European countries quickly approved thalidomide without question. Dear Kim Kardashian: Those pesky FDA rules are there for a reason 2015-08-17T04:00:00Z An early success story is the controversial drug thalidomide. The cancer drugs in your bathroom cabinet 2016-06-12T04:00:00Z Ms. Kelsey and the thalidomide story would be tragically different today. Today’s drug safety standards 2015-08-10T04:00:00Z During these discussions, reports began emanating from Europe that thalidomide, also being prescribed to pregnant women to prevent morning sickness, led to horrific birth defects. Thalidomide, Drug Marketing And FDA Oversight 2015-08-10T04:00:00Z But the babies whose mothers took thalidomide in the United States were largely forgotten. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Food and Drug Administration in the early 1960s when she raised concerns about thalidomide, a drug that was being used in other countries to treat morning sickness and insomnia in pregnant women. Frances Kelsey, a Hero During the Thalidomide Scourge, Dies at 101 2015-08-08T04:00:00Z Many legal settlements were reached between drug companies and the victims of thalidomide, and new claims continue to surface. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z Frances Oldham Kelsey, the Canadian doctor who played a central role in preventing the drug thalidomide being distributed in the US, has died at 101. Anti-thalidomide hero Frances Oldham Kelsey dies at 101 - BBC News 2015-08-07T04:00:00Z In February 1961, she read a letter in The British Medical Journal from a doctor who suggested that thalidomide might be causing a numbing condition in arms and legs. Frances Oldham Kelsey, F.D.A. Stickler Who Saved U.S. Babies From Thalidomide, Dies at 101 2015-08-07T04:00:00Z Two American companies explored bringing thalidomide to the United States. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z More than 10,000 babies worldwide were born with limb deformities and other problems linked to thalidomide before it was withdrawn by its German manufacturer Grunenthal. Thalidomide survivors seek 'justice' with Plaid Euro MP - BBC News 2015-05-31T04:00:00Z In 2006, thalidomide was cleared for use with the medicine dexamethasone for certain cases of multiple myeloma, a cancer of the bone marrow. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z It was later found that thalidomide - prescribed to pregnant women to ease morning sickness - was causing thousands of babies to be born with missing limbs or organs. Anti-thalidomide hero Frances Oldham Kelsey dies at 101 - BBC News 2015-08-07T04:00:00Z No one knows how many babies were affected by thalidomide, but estimates range into the tens of thousands in Europe alone. Frances Oldham Kelsey, F.D.A. Stickler Who Saved U.S. Babies From Thalidomide, Dies at 101 2015-08-07T04:00:00Z The question of who is a thalidomide survivor has persisted since the earliest days of the crisis. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Welsh people left disabled by the thalidomide drug scandal are being backed in their fight for compensation by Plaid Cymru MEP Jill Evans. Thalidomide survivors seek 'justice' with Plaid Euro MP - BBC News 2015-05-31T04:00:00Z But because of her tenacity and clinical training, she became the central figure in the thalidomide episode. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z Dr Kelsey - who worked at the US Food and Drug Administration - is seen as a hero by many across the US for raising concerns about the safety of thalidomide, which is also known as Kevadon. Anti-thalidomide hero Frances Oldham Kelsey dies at 101 - BBC News 2015-08-07T04:00:00Z The drug — better known by its generic name, thalidomide — was causing thousands of babies in Europe, Britain, Canada and the Middle East to be born with flipperlike arms and legs and other defects. Frances Oldham Kelsey, F.D.A. Stickler Who Saved U.S. Babies From Thalidomide, Dies at 101 2015-08-07T04:00:00Z She believes someone must be held accountable for the trials, even if thalidomide was never approved in the United States. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Despite the availability of free multi-drug therapy, some countries, especially Brazil, continue to treat some forms of leprosy with thalidomide. Leprosy Isn't Gone -- And Women Bear The Burden 2015-03-06T05:00:00Z Clinical investigators, because of a variety of complications including spotty tracking systems, only belatedly made the link to thalidomide. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z In 1962, the drug development process was seen as too fast because of the thalidomide disaster, in which a drug intended to relieve morning sickness caused birth defects. MedidataVoice: Rare Disease Patient Voices Bring Change To The Clinical Trials Process 2014-09-25T04:00:00Z The thalidomide tragedy highlighted the need for the FDA and consumer protection. Need a Hand? Now You Can Print One 2014-03-06T16:45:51Z As part of her quest to understand her story, Ms. Sampson asked the F.D.A. for the list of American doctors who distributed thalidomide. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z This is resulting in more children being born with phocomelia, or absent limbs, as thalidomide is teratogenic. Leprosy Isn't Gone -- And Women Bear The Burden 2015-03-06T05:00:00Z Babies who suffered from the effects of thalidomide and survived grew up with a range of impairment. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z The 55-year history of the drug thalidomide is Shakespearean in scope, awash in unintended consequences, tragedy, resilience, driven characters, and redemption. [Perspective] How Thalidomide Works Against Cancer 2014-01-16T18:55:52.372Z A dramatic example is thalidomide, the drug prescribed for anxiety and morning sickness that led to birth defects. Could the Internet Become a Failed Technology? 2014-01-07T14:04:38Z She said she had struggled to make peace with the idea that she would never know for sure whether she is a thalidomide survivor. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z But in the early 1970s, nobody knew how long thalidomide survivors would live for, how they would age, of if further symptoms of the drug would materialise in later life. Ageing in the wake of thalidomide 2013-07-30T13:28:12Z Researchers have investigated thalidomide’s effects on H.I.V. and Crohn’s disease and have conducted clinical trials for on its use for rheumatoid arthritis and macular degeneration, a leading cause of blindness. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z Another possibility is a teratogen: a birth defect-inducing toxicant along the lines of thalidomide. Bizarre 6-Inch Skeleton Shown to Be Human 2013-05-03T23:40:00Z Around 2,700 victims of thalidomide are entitled to pensions from the government. Germany increases pensions for thalidomide victims 2013-04-26T10:35:07Z Jennifer Vanderbes, who is researching a book about the history of thalidomide in the United States, said society owed the survivors in America a debt of gratitude. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Speaking 40 years since a compensation deal for thalidomide survivors was agreed, Mrs Masters - now a grandmother of six - says the sums paid might still not be enough. Ageing in the wake of thalidomide 2013-07-30T13:28:12Z While Dr. Kelsey stood her ground on Kevadon, infant deaths and deformities were occurring at an alarming rate in places where thalidomide had been sold. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z It was responsible for the thalidomide drug, intended to combat morning sickness during pregnancy, but which led to numerous physical deformations in babies. How Scotch whisky conquered the world 2013-01-09T01:38:15Z Martin Johnson, director of the Thalidomide Trust, said the survivors felt a "massive sense of injustice" towards the German manufacturers of thalidomide, Gruenenthal. £80m grant for Thalidomide survivors 2012-12-20T13:01:50Z Doctors were not initially told it was thalidomide; the pills instead carried the label SK&F #5627, according to federal court documents. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Given a life expectancy of 19 years, Mandy was one of more than 10,000 babies worldwide born with a disability caused by the drug thalidomide. Ageing in the wake of thalidomide 2013-07-30T13:28:12Z “She may have had a bigger effect after thalidomide than before.” Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z The money, announced on Thursday by the government, will help the 325 remaining people in England who were affected by thalidomide to adapt their homes or cars and buy hearing aids. Thalidomide survivors to receive £80m of public funding 2012-12-20T20:07:15Z Mr Poots said extending the grant would provide some security to thalidomide survivors in Northern Ireland. Thalidomide health grant extended 2012-12-20T15:57:27Z Estimates of how many American babies were affected by thalidomide have varied. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z "The tree is a living tribute to all those affected by the thalidomide drug," he said. Memorial for thalidomide victims 2012-11-23T16:56:44Z Since only small numbers of patients participate in clinical trials, and some adverse events occur very rarely, side effects like the phocomelia, the small flipper-like limb deformities associated with thalidomide, are not detected until post-marketing. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z They were born to mothers who between 1958 and 1961 took thalidomide while pregnant for morning sickness, before its dangers were realised. Thalidomide survivors to receive £80m of public funding 2012-12-20T20:07:15Z In July, an Australian woman born without arms and legs after her mother took thalidomide reached a multimillion-dollar settlement with the drug’s British distributor. Grünenthal Group Apologizes to Thalidomide Victims 2012-09-01T19:15:46Z Infants injured by thalidomide suffered a range of ailments, but the focus was on the most severe cases. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The charity supporting British survivors, Thalidomide UK, said it was estimated that for every thalidomide baby that lived there were 10 that died. Memorial for thalidomide victims 2012-11-23T16:56:44Z This tragic effects of thalidomide on developing embryos marks one of the most notorious failures in the history of drug development. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z She dreads a life in a wheelchair, a fate which befalls some thalidomide survivors. Embracing a life without arms 2012-09-01T13:42:37Z Mr. Stock spoke in Stolberg, the city in which the company is based, during the unveiling of a bronze statue symbolizing a child born without limbs because of thalidomide. Grünenthal Group Apologizes to Thalidomide Victims 2012-09-01T19:15:46Z That ambiguity is built into the story of thalidomide in the United States. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Thalidomide UK says there are 458 people in the UK who were affected by the drug, but that for every thalidomide baby that lived there were 10 that died. Thalidomide apology 'insulting' 2012-09-01T08:39:08Z Studies are in process for using thalidomide to treat the chronic cough of interstitial fibrosis, as well. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z Food and Drug Administration demands a toxicity study for thalidomide to prove it is safe in humans. 1960s - Thalidomide is marketed in Europe, Australia, Canada and Japan. Key dates in history of thalidomide 2012-08-31T21:16:04Z Mr Stock spoke as he unveiled a bronze statue symbolising a child born without limbs because of thalidomide. Thalidomide maker issues apology 2012-08-31T20:41:22Z Today, as the coronavirus circles the globe — claiming thousands of lives — there is a renewed push to rush potential cures to market, even if it means bypassing the checks and balances that were thalidomide’s legacy. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z Harald Stock, Gruenenthal's chief executive, issued his company's apology at the unveiling of a bronze statue symbolising a child born without limbs because of thalidomide. Thalidomide apology 'insulting' 2012-09-01T08:39:08Z My father followed that path, making artificial limbs and prosthesis—almost certainly for thalidomide babies among them. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z The birth defects are eventually linked to thalidomide and the drug is pulled from the market. Key dates in history of thalidomide 2012-08-31T21:16:04Z Rowe smiled as she left the courthouse and said she was pleased others harmed by thalidomide will now have the chance to seek compensation from Diageo. Australian wins millions in thalidomide lawsuit 2012-07-18T04:04:08Z Her mother, whose last name is now Martin, had heard about thalidomide, but said she didn’t connect it to Carolyn’s defects. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z In one case, Celgene dramatically raised the price of thalidomide after it was found to be effective not just against complications of HIV and leprosy, but the blood cancer multiple myeloma. Immune Reversal: Unsuccessful Pfizer AIDS Drug Might Help Transplant Patients 2012-07-11T21:57:33Z After helping the US chemical industry, he went on to become chairman of Grünenthal’s advisory committee when thalidomide was developed. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z Jack worked with incredible energy for the disabled, of whom plenty turned out, including probably dozens of thalidomide victims, for whom he fought ferociously against the Distillers Company, alongside Harry Evans of the Sunday Times. All our banksters do, they do for you 2012-07-06T20:00:02Z In the late 1950s thalidomide was marketed as safe for mother and child. Letters: Bankers at the point of no return 2012-06-29T20:00:02Z Internal F.D.A. reports, obtained through a recent public records request, show just how chaotic the distribution of thalidomide had been. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The notorious thalidomide caused birth defects in the 1960s when some countries used it for morning sickness, but today it treats multiple myeloma. NIH, companies aim to teach old drugs new tricks 2012-05-03T17:44:10Z Their treatments are focused on oral drugs such as thalidomide and lenalidomide, as well as conventional chemotherapy. Drugs: More shots on target 2011-12-14T18:21:03.017Z Until now, most US cases were thought to originate from thalidomide obtained abroad. Lawsuit Blames Thalidomide for More Birth Defects 2011-11-08T22:15:08.367Z Pictures of them are common there, reminiscent of “thalidomide babies” in the 1950s and victims of mercury poisoning in Minamata, Japan. Global Update: Pesticides: Ban on a Cousin of DDT Has Loopholes in India, Where Children Were Harmed 2011-05-02T20:03:36Z The Americans who believe they are survivors say they want to spread the word that thalidomide harmed babies in the United States, too. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The initial cost of the drug was $6,200 a month, more than double that for thalidomide. Geraldine Ferraro And The High Cost Of Cancer Drugs 2011-03-27T15:46:48Z Lenalidomide, a derivative of thalidomide and also approved in 2006 for use in multiple myeloma, is now preferred over thalidomide because it is less likely to cause peripheral neuropathy. Drugs: More shots on target 2011-12-14T18:21:03.017Z "There are no representative, controlled studies documenting the true spectrum of thalidomide injuries," they write in the lawsuit. Lawsuit Blames Thalidomide for More Birth Defects 2011-11-08T22:15:08.367Z She was one of the first cancer patients to be treated with thalidomide, a drug used in the 1960s to treat morning sickness that caused severe defects in unborn children. Geraldine A. Ferraro, First Woman on Major Party Ticket, Dies at 75 2011-03-26T19:49:50Z “Are you a thalidomide baby?” he asked as she waited to get off. The Unseen Survivors of Thalidomide Want to Be Heard 2020-03-23T04:00:00Z The thalidomide disaster led Congress to pass legislation giving the F.D.A. authority to demand that drug makers prove their products safe and effective. The Public?s Quiet Savior From Harmful Medicines 2010-09-14T04:30:00Z Kelsey was steadfast, and her resistance became the stuff of legend when it turned out that thalidomide caused severe birth defects in thousands of babies born in Europe and elsewhere. Physician to be honored for historic decision on thalidomide 2010-09-14T01:17:00Z In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug. Lawsuit Blames Thalidomide for More Birth Defects 2011-11-08T22:15:08.367Z The pill’s role in the maturing of the F.D.A. has often been overlooked because shortly after the agency’s approval of the contraceptive, news of the horrific effects of thalidomide swept the world. The Pill Started More Than a Sexual Revolution 2010-05-03T22:08:00Z She was treated at first with thalidomide, an orally administered immune stimulant that also blocks blood flow to tumor cells. Personal Health: Cancer Survival Demands Steady Scientific Progress 2010-04-12T20:54:00Z The technology used by Touch Bionics is based on prostheses that the National Health Service in Scotland developed for children there who suffered effects of the drug thalidomide, he said. Novelties: Prosthetic Fingers That Grab Gracefully 2010-04-10T20:10:00Z As a young researcher at the University of Chicago, Kelsey had been concerned about the dangers that drugs can have on fetuses, and she held that in mind as she handled the thalidomide case. Physician to be honored for historic decision on thalidomide 2010-09-14T01:17:00Z She notes that Smith Kline & French never manufactured or sold thalidomide and adds: "The Plaintiffs' complaint is replete with scientific inaccuracies and misstatements." Lawsuit Blames Thalidomide for More Birth Defects 2011-11-08T22:15:08.367Z Although thalidomide was never approved in the United States, the horror surrounding its effects led Congress to toughen the drug approval process by requiring manufacturers to prove their medicines were both safe and effective. The Pill Started More Than a Sexual Revolution 2010-05-03T22:08:00Z "Biopsies of the nasal surface tissue from patients with HHT showed that similar mechanisms may explain the effects of thalidomide treatment in humans," he wrote in the study. Thalidomide drug may fight blood vessel disorder 2010-04-04T17:03:00Z Despite the devastation, thalidomide is still in use today. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z The United States was not entirely spared in the thalidomide tragedy. Physician to be honored for historic decision on thalidomide 2010-09-14T01:17:00Z Vargesson says his work does not confirm or deny that the plaintiffs' defects are the result of thalidomide. Lawsuit Blames Thalidomide for More Birth Defects 2011-11-08T22:15:08.367Z Research in the journal Science reveals that thalidomide binds to and renders inactive the protein cereblon, which is very important in limb formation. Thalidomide effect mystery solved 2010-03-11T19:45:00Z The assembly government funding, which will be available from April, will be given to the Thalidomide Trust to distribute to people with thalidomide to improve their care and support. ?1.9m for thalidomide survivors 2010-02-26T11:52:00Z And some said that thalidomide slipped into the DNA of cells in a developing limb, preventing the cells from making the proteins they needed. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z Cash for thalidomide survivors Victims of the thalidomide scandal will be given extra help through a £3.4m fund announced by the Scottish government. Cash for thalidomide survivors 2010-02-26T00:45:00Z The thalidomide scandal triggered a worldwide overhaul of drug-testing regimes and boosted the reputation of the U.S. 2010-01-14T18:32:00Z Medical researchers would therefore like to develop drugs that mimic the action of thalidomide, but do not affect limb development. Thalidomide effect mystery solved 2010-03-11T19:45:00Z I believe that addressing the ongoing needs of thalidomiders rests with the UK government as it authorised the use of thalidomide. ?1.9m for thalidomide survivors 2010-02-26T11:52:00Z The complexity of thalidomide and the obscurity of limb formation left scientists stymied. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z Half a century later, the survivors of thalidomide are still battling against the disabilities the prescribing of the drug caused. Cash for thalidomide survivors 2010-02-26T00:45:00Z O'Brien announced the government would additionally fund a 20 million pound, three-year pilot scheme to meet the health needs of thalidomide survivors. 2010-01-14T18:32:00Z "It's an apology not just to thalidomide victims but to the parents who lost their children in the early days." 2010-01-14T10:55:00Z Sure, most of them will have their hearts explode or break out into great purple bleeding thalidomide warts. The Cyberpunk Fakebook In 2006, he and a team of collaborators began a survey of the metabolites of thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z But within a few years, doctors in Germany and Australia noticed a rise in phocomelia and eventually linked it to thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z Researchers are testing thalidomide in trials for other diseases including H.I.V. and Crohn’s disease. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z In the 1960s, developmental biologists began to inject thalidomide into animal embryos to trigger phocomelia. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z Some scientists argued that thalidomide damaged nerves in developing limbs. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z An embryo exposed to thalidomide at that point would suffer damage to its limbs, Dr. Vargesson said, while the rest of it would suffer less damage because its blood vessels were already mature. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z To find that target, Dr. Hiroshi Handa of the Tokyo Institute of Technology and his colleagues coated microscopic beads with thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z And, just as humans lose limbs, zebrafish lose fins when they are exposed to thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z The scientists speculated that thalidomide caused the defects by disabling cereblon proteins. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z In order for thalidomide to do its damage, it must grab on to some particular kind of molecule in the embryo. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z They injected the altered cereblon into the wings of chick embryos along with thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z The chicks grew relatively normal wings despite the thalidomide. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z He said that scientists now needed to see if thalidomide was also binding to proteins other than cereblon. 50 Years After Defect Tragedy, Finding Answers on How Thalidomide Caused Defects 2010-03-15T22:49:00Z |
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