| 单词 | tamoxifen |
| 例句 | “Most cancers have receptors on their surface that bind to drugs like tamoxifen, but triple negative doesn’t,” Nithiyanandam explained. ‘It's not about your age, it's about your ideas’: the teen power list 2016-12-10T05:00:00Z “When it happened,” Françoise remembers, “she was devastated but began treatments again and responded well to tamoxifen.” The world of the widow: grappling with loneliness and misunderstanding 2015-10-05T04:00:00Z For example, for breast cancer survivors taking long-term estrogen inhibitor medications, such as tamoxifen, certain supplements may interfere with the metabolism of the estrogen inhibitor, potentially making it less effective. Advice | Ask a Doctor: What treatments work for women with thinning hair? 2022-10-17T04:00:00Z Following her treatment, Brown suffered from fatigue and brain fog on the tamoxifen she took for years to prevent cancer recurrence. Review | A former nurse calls out the lack of compassion in health care 2022-05-13T04:00:00Z One class consists of two drugs, tamoxifen and raloxifene, that inhibit the action of estrogen in selective tissues. Medication and Lifestyle May Lower Breast Cancer Risk 2020-08-24T04:00:00Z Unsurprisingly, the oestrogen blocker tamoxifen was shown to inhibit this action. The gender gap in cystic fibrosis 2020-07-28T04:00:00Z But cancer cells that are resistant to tamoxifen produce much higher levels of MED1, and the team found that this causes the condensates to balloon in size, diluting the drug and weakening its effect. Cells’ ‘lava lamp’ effect could make drugs more powerful 2020-06-17T04:00:00Z Plaquenil’s label warns of possible damage to the retina, especially when used at higher doses, for longer times and with certain other medicines such as the breast cancer drug tamoxifen. Malaria drugs’ promise for coronavirus spurs hope, shortages 2020-03-23T04:00:00Z However, tamoxifen is effective in women before the menopause. Drug 'can prevent half of breast cancers' 2019-12-12T05:00:00Z Dr. Fisher also investigated the benefits of hormone therapy such as tamoxifen, which is used to prevent the recurrence or even, in some cases, the onset of estrogen-sensitive breast cancer. Bernard Fisher, pioneering breast cancer surgeon-scientist, dies at 101 2019-10-23T04:00:00Z He and his colleagues wanted to test the efficacy of a treatment regimen commonly followed by people with a certain type of early-stage breast cancer: surgery followed by the drug tamoxifen and radiation therapy. An AI boost for clinical trials 2019-09-24T04:00:00Z They have developed medications that extend lives, such as Herceptin and tamoxifen for breast cancer and Gleevec for leukemias and other cancers. Cancer Medicine Is Failing Us 2019-08-04T04:00:00Z These women may benefit from a longer course of hormone therapy drugs like tamoxifen. Cancer's 'internal wiring' predicts relapse risk 2019-03-13T04:00:00Z Hormone therapy, like tamoxifen or aromatase inhibitors taken orally, slows the progression of certain kinds of tumors. For Elderly Women With Breast Cancer, Surgery May Not Be the Best Option 2018-09-14T04:00:00Z Generally, after surgery, such patients receive endocrine therapy, such as tamoxifen, which is designed to block the cancer- spurring effects of hormones. Most women with a common type of early-stage breast cancer can skip chemo, a new report finds 2018-06-03T04:00:00Z Every patient received treatments such as tamoxifen or aromatase inhibitors which block the effects of oestrogen or shut off the hormone's supply. Breast cancer 'can return after 15 years' 2017-11-09T05:00:00Z In breast cancer, for example, “if you can’t do a mastectomy or use tamoxifen, you probably shouldn’t even try to treat,” he said. As Cancer Tears Through Africa, Drug Makers Draw Up a Battle Plan 2017-10-07T04:00:00Z This, she thought, was more thorough than simply blocking oestrogen receptors, as drugs such as tamoxifen did. Angela M. Hartley Brodie (1934-2017) : Nature : Nature Research 2017-08-01T04:00:00Z Angela Brodie later told The Washington Post she was doubtful about how effectively tamoxifen — itself a weak estrogen — could fight the growth of tumors. Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82 2017-06-08T04:00:00Z Some women also end up taking an anti-cancer drug — such as tamoxifen — for several years. Waiting and watching with ‘Stage 0’ breast cancer put to nationwide test 2017-04-29T04:00:00Z Drugs such as tamoxifen and bulsufan are now 10 times more expensive despite no longer being under patent. Cancer drugs price rise 'costing NHS millions' - BBC News 2017-01-29T05:00:00Z Genome sequencing of her tumour revealed that her original cancer was a mosaic of cell types; the tamoxifen had tamed the hormone-sensitive cancer cells, but the insensitive ones had survived. The sparrow with four sexes 2016-11-22T05:00:00Z The CYP2D6 gene, for instance, is involved in the metabolism of many commonly prescribed drugs, including tamoxifen, which is used to treat breast cancer. Genomics is failing on diversity 2016-10-11T04:00:00Z Dr. Brodie’s efforts culminated in the second generation of hormone therapies to combat breast cancer, after earlier drugs such as tamoxifen. Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82 2017-06-08T04:00:00Z Both groups will be offered tamoxifen or other drugs to reduce the risk of recurrence. Waiting and watching with ‘Stage 0’ breast cancer put to nationwide test 2017-04-29T04:00:00Z The tamoxifen is prescribed for five years, and she has been taking it for three. 2 women develop bond as they fight breast cancer 2016-10-09T04:00:00Z The couple was shocked — their son was only 11 — but a mastectomy and the drug tamoxifen seemed to contain the disease. The sparrow with four sexes 2016-11-22T05:00:00Z Risk reductions were smaller but still significant at least five years after stopping tamoxifen therapy, the study authors noted in a news release. More Evidence Tamoxifen, Other Meds Help Limit Breast Cancer's Spread 2016-10-06T04:00:00Z In addition, research had shown that tamoxifen had a higher risk of causing endometrial cancer and strokes for some patients. Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82 2017-06-08T04:00:00Z "Many women who would benefit from taking tamoxifen fail to do so because they fear getting endometrial cancer," first author Dr. Ronald Potkul said in a Loyola news release. Tamoxifen OK for Breast Cancer Patients Without Uterine Abnormalities: Study 2016-09-22T04:00:00Z She believes the new study supports the benefit of aromatase inhibitors, and "women are much more likely to continue a longer course with this therapy" than with tamoxifen. Longer Use of Certain Drugs Cuts Recurrence for Breast Cancer Survivors 2016-06-06T04:00:00Z Typically, that kind of drug is taken for five years, sometimes after a course of tamoxifen, which acts as an anti-estrogen drug in the breast. Extending anti-estrogen therapy to 10 years reduces breast-cancer recurrence, new cancers 2016-06-05T04:00:00Z However, the risk of this happening declined the longer patients took tamoxifen, Gierach's team found. More Evidence Tamoxifen, Other Meds Help Limit Breast Cancer's Spread 2016-10-06T04:00:00Z At the time, cancer researchers were encouraged by the new drug tamoxifen, which prevents estrogen from binding to cancer cell receptors. Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82 2017-06-08T04:00:00Z National Cancer Institute provides more information on tamoxifen and hormone therapy for breast cancer. Tamoxifen OK for Breast Cancer Patients Without Uterine Abnormalities: Study 2016-09-22T04:00:00Z Up to three years of tamoxifen, followed by five years of aromatase inhibitors is a common practice. Breast cancer: Taking hormonal drugs for up to 15 years can reduce risk - study - BBC News 2016-06-05T04:00:00Z Clinicians knew from previous studies that using tamoxifen for up to 10 years was better than using it for five years, but there wasn’t corresponding data for aromatase inhibitors. Extending anti-estrogen therapy to 10 years reduces breast-cancer recurrence, new cancers 2016-06-05T04:00:00Z Use of aromatase inhibitors without tamoxifen was also associated with reduced risk of cancer in the previously unaffected breast, the findings showed. More Evidence Tamoxifen, Other Meds Help Limit Breast Cancer's Spread 2016-10-06T04:00:00Z But the majority of postmenopausal women now start on an aromatase inhibitor, not tamoxifen. Extending Estrogen Suppressor May Aid Breast Cancer Patients, Study Says 2016-06-05T04:00:00Z Five abnormalities were found in the tamoxifen-only group, and one in the group taking tamoxifen with progestin, according to the study published in npj Breast Cancer. Tamoxifen OK for Breast Cancer Patients Without Uterine Abnormalities: Study 2016-09-22T04:00:00Z Prescription tamoxifen or raloxifene may lower breast cancer risk in post-menopausal women; tamoxifen may do the same in high-risk premenopausal women. You just heard another alarming health report. Should you be scared? 2016-01-04T05:00:00Z Primary care doctors should advise breast cancer survivors about the need to maintain a healthy lifestyle and adhere to endocrine therapy -- hormonal treatments such as tamoxifen, used to keep cancer at bay. Experts Issue Guidelines on Caring for Breast Cancer Survivors 2015-12-07T05:00:00Z Previous research suggested that antidepressants reduce the effectiveness of tamoxifen, so Haque's team conducted a study to determine if that was true. Safe to Take Antidepressants With Tamoxifen: Study 2015-12-04T05:00:00Z Lipinski was supposed to have surgery at the end of the trial, but she opted to forego the operation and continue with the tamoxifen, and, later, raloxifene. Molecular biology: Marked progress : Nature : Nature Publishing Group 2015-11-17T05:00:00Z Today, tamoxifen is one of many hormone-blocking drugs used worldwide to treat — and in some cases prevent — certain types of breast cancer. A tumour through time : Nature : Nature Publishing Group 2015-11-17T05:00:00Z For example, there are substantial data to show that patients with two defective CYP2D6 alleles are more likely to experience recurrence of breast cancer after treatment with tamoxifen. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z Regarding aromatase inhibitors, she said that in her practice, patients entering or in menopause "are treated with two years of tamoxifen, and then I switch to aromatase inhibitors once menopause is confirmed." Certain Generic Meds May Help Older Patients With Early Breast Cancer 2015-07-23T04:00:00Z The study included nearly 16,900 early stage breast cancer survivors who took tamoxifen for an average of three years. Safe to Take Antidepressants With Tamoxifen: Study 2015-12-04T05:00:00Z One of the most successful breast cancer drugs, tamoxifen, bungs up the oestrogen receptor. Drug could help slow half of breast cancers, study suggests - BBC News 2015-07-08T04:00:00Z The fresh hope emerged from research in animals which found that the hormone, progesterone, slowed the growth of breast cancers when it was combined with tamoxifen, the standard drug treament. Breast cancer hope as hormone shown to slow tumour growth 2015-07-08T04:00:00Z This is because these patients produce much lower levels of the active tamoxifen metabolite, endoxifen, than those without defective alleles30, 31, 32, 33, 34, 35. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z Those women might want to be screened more often, or consider starting the drug tamoxifen, which cuts breast cancer risk. MRI Might Predict Breast Cancer Risk in Some Women 2015-05-12T04:00:00Z Doctors may also prescribe drugs like tamoxifen to reduce the risk of cancer developing. Preventive surgery for cancer genes 2015-03-24T04:00:00Z Cancer cells growing in the laboratory grew to half the size when treated with progesterone and tamoxifen than when given tamoxifen alone. Drug could help slow half of breast cancers, study suggests - BBC News 2015-07-08T04:00:00Z They found that adding progesterone to double positive cancers, along with tamoxifen, slowed their growth more than the drug alone. Breast cancer hope as hormone shown to slow tumour growth 2015-07-08T04:00:00Z One is tamoxifen, an estrogen-blocker sold under various brand names that reduces the risk of developing breast cancer. Lee W. Wattenberg, Who Saw Cancer Fighters in Foods, Dies at 92 2014-12-18T05:00:00Z Right now, surgery is often followed by radiation and, in some cases, the drug tamoxifen, said Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society. Gene Test May Help Predict Return of Early Breast Tumor, Study Says 2014-12-12T05:00:00Z Those assigned to take tamoxifen did so for only five years on study. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z Half took 20 milligrams of tamoxifen daily for five years and the others took an inactive placebo for five years. New Treatment Shows Promise in Younger Breast Cancer Patients: Study 2014-12-11T05:00:00Z The researchers found that only 77 percent of men got endocrine therapy such as tamoxifen for their cancer when it was indicated. Male Breast Cancer Is Different 2014-12-09T05:00:00Z To see if there might be a better way, Dr. Khan prescribed tamoxifen in the form of either a pill or a gel applied to the breast to 26 women awaiting surgery for DCIS. 6 Medical Breakthroughs That Matter 2014-10-23T04:00:00Z But after six months of chemotherapy and radiation and three rounds of surgery, we had to wait five years while I was on tamoxifen, a cancer-fighting drug that can cause birth defects. Why I don’t breastfeed, if you must know Deaths were more frequent in women assigned to receive tamoxifen, although the differences did not meet statistical significance. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z This may mean a risk-reducing mastectomy, cancer preventing drugs, such as tamoxifen, and certain lifestyle changes like a healthy diet and more exercise. Cancer test 'Jolie effect' found 2014-09-18T04:00:00Z Dr. Khan’s study was small—only 26 women—but it provides proof that the principle of applying tamoxifen directly on the breast may be worth investigating. Treating Breast Cancer With a Gel? It May Be Possible 2014-07-15T04:00:00Z Using data from about 680 patients, the researchers are doing further testing on the effectiveness of the gene signature in predicting whether women at risk would respond to tamoxifen therapy. Skin gel new ammunition in fight against breast cancer That's why aromatase inhibitors have traditionally been used in postmenopausal women, and have been shown to work better for them than tamoxifen. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z Yesterday researchers updated long-term findings of a large, randomized trial evaluating tamoxifen in its capacity and safety as a breast cancer preventive. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z The researchers looked at the patients' use of either an aromatase inhibitor or tamoxifen, both of which are drugs that prevent tumors from using estrogen to grow. Older Breast Cancer Patients Do Follow Drug Therapy: Study 2014-06-16T04:00:00Z Khan analyzed the breast tissue after surgery to study markers for tumor growth, and conducted blood tests for levels of tamoxifen metabolites as well. Treating Breast Cancer With a Gel? It May Be Possible 2014-07-15T04:00:00Z After six to 10 weeks of gel application, the reduction in a marker for cancer cell growth in the breast tissue was similar to that of the orally administered tamoxifen, the study found. Skin gel new ammunition in fight against breast cancer For tamoxifen, side effects included blood clots, hot flashes and urinary incontinence, according to the study. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z The women were assigned to take either tamoxifen or a placebo for five years. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z The researchers added HCQ to the mice’s treatment with tamoxifen and discovered that the malaria did in fact increase tumor responsiveness to the breast cancer drug. Treating Cancer With A Malaria Drug 2014-06-13T04:00:00Z By comparison, tamoxifen blocks estrogen from being used by cancer cells. Newer Anti-Estrogen Treatment May Benefit Younger Breast Cancer Survivors 2014-06-01T04:00:00Z "Many women taking adjuvant tamoxifen experience side effects, and these appear to persist with longer duration. However, the trials did not find any new or unexpected side effects," she noted. New Guidelines Recommend Longer Tamoxifen Treatment 2014-05-27T04:00:00Z Compared to tamoxifen, Aromasin reduced the risk of breast cancer recurrence by 34 percent. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z Now with a median follow-up of 16 years, the trial shows an extended, dramatic reductive effect of tamoxifen on the incidence of breast tumors. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z The reason some woman become resistant to tamoxifen is that a “pro-survival” cell pathway in the breast cancer cells becomes switched. Treating Cancer With A Malaria Drug 2014-06-13T04:00:00Z There was a 34 percent reduction in the risk of breast cancer recurrence in the exemestane group compared to the tamoxifen group. Newer Anti-Estrogen Treatment May Benefit Younger Breast Cancer Survivors 2014-06-01T04:00:00Z In the two largest studies with the longest follow-up, patients who took tamoxifen for 10 years after initial treatment survived longer than women who took the drug for five years. New Guidelines Recommend Longer Tamoxifen Treatment 2014-05-27T04:00:00Z "Compared to aromatase inhibitors, the quality of life is better with tamoxifen for premenopausal women," she said. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z Worrisome, too, is a slightly increased number of estrogen-receptor negative tumors observed in the tamoxifen arm of the study. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z HCQ turns off the modified cell pathway, which helps prevent resistance to tamoxifen. Treating Cancer With A Malaria Drug 2014-06-13T04:00:00Z Reported side effects were similar to those in previous studies that compared aromatase inhibitors and tamoxifen in postmenopausal women, and differed depending on the drug. Newer Anti-Estrogen Treatment May Benefit Younger Breast Cancer Survivors 2014-06-01T04:00:00Z The latest recommendation on tamoxifen treatment is based on new data from five studies reviewed since the society's previous update in 2010. New Guidelines Recommend Longer Tamoxifen Treatment 2014-05-27T04:00:00Z But, women on tamoxifen had more blood clots, hot flashes, sweating and urinary incontinence, according to the study. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z Remarkably, after a median of 16 years on study, approximately 75 percent of the women who have not developed breast cancer remain “blinded” as to whether they received tamoxifen or the placebo. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z ER+ breast cancers are some of the most common, and are often treated with tamoxifen. Treating Cancer With A Malaria Drug 2014-06-13T04:00:00Z Calathes, a reserve guard, was suspended for 20 games on Friday for violating the league’s antidrug policy by testing positive for tamoxifen. N.B.A. Roundup: Atlanta Races Past Top-Seeded Indiana in Game 1 2014-04-20T03:08:03Z For example, tamoxifen increases the risk of endometrial cancer and dangerous blood clots. Could half of all breast cancers be prevented? 2014-03-26T14:08:24Z These "may be more noxious to young women than the hot flushes experienced with tamoxifen," she wrote. Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women 2014-07-09T04:00:00Z An unanticipated result is that non-melanoma skin cancers developed disproportionately among women on tamoxifen: those number were 116 and 84, respectively. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z With better treatments, like tamoxifen, it was less important to find cancers early. Study Adds New Doubts About Value of Mammograms 2014-02-11T23:44:31Z This month, for example, HHS released guidance saying that women at increased risk of breast cancer could receive, without cost sharing, medications such as tamoxifen and raloxifene . Getting charged for ‘free’ preventive care 2014-01-20T21:12:08Z "But it adds very important evidence for recommending the drug as an alternative to tamoxifen, we now need to identify those women at highest risk who will benefit the most from this treatment." Drug 'halves' breast cancer risk 2013-12-12T13:30:10Z Not all tumours will respond to drugs like tamoxifen Young black women in the UK are more likely than their white counterparts to develop "worse" breast cancer with a poorer prognosis, research suggests. Black women get 'worse' breast cancer 2013-10-22T23:41:59Z Notably, the number of estrogen-negative breast cancers increased in the tamoxifen arm at 16 years, although this trend didn’t reach statistical significance. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z But an editorial accompanying the new study said that earlier studies that found mammograms helped women were done before the routine use of drugs like tamoxifen that sharply reduced the breast cancer death rate. Study Adds New Doubts About Value of Mammograms 2014-02-11T23:44:31Z Those drugs, tamoxifen and raloxifene, block the effects of estrogen in breast tissue. Discuss cancer-reducing meds with at-risk women: panel 2013-09-23T21:01:21Z But he cautioned that tamoxifen was recommended for just a "relatively small percentage" of people so far. Drug 'halves' breast cancer risk 2013-12-12T13:30:10Z Such women might respond less well to breast cancer drugs like tamoxifen because of the genetic make-up of their tumour, they say. Black women get 'worse' breast cancer 2013-10-22T23:41:59Z Five deaths were seen from endometrial cancer, all on the tamoxifen arm. Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long-Term Follow-Up 2014-12-12T05:00:00Z Adrienne Morgan, who has had to take tamoxifen, tells the paper that the drug is "a nightmare", with hot flushes occurring every 45 minutes. Papers assess impact of care costs 2013-09-04T04:36:25Z The new findings suggest taking tamoxifen may be another breast-cancer-preventing option for those women, whether or not they have already had cancer once, researchers said. Tamoxifen cuts second cancer risk in BRCA carriers 2013-08-16T15:47:34Z Some countries already offer the drugs tamoxifen and raloxifene to prevent breast cancer. Drug 'halves' breast cancer risk 2013-12-12T13:30:10Z Other warnings include an increased risk of bleeding, and possible reduction in the effectiveness of the breast cancer drug tamoxifen if both drugs are used together. F.D.A. Approves a Drug for Hot Flashes 2013-06-29T02:16:24Z Based on research findings, experts estimate that for every 1,000 women given tamoxifen, there would be 20 fewer breast cancers. 'At risk' offered breast cancer drug 2013-06-24T23:55:57Z Researchers estimated that, compared with taking no tamoxifen, 10 years of the drug reduces breast cancer death rates by a third in the first 10 years and by half after that. Longer use of tamoxifen shown to cut risk of breast cancer recurrence 2013-06-02T11:37:37Z The American Society of Clinical Oncology says a 5-year course of tamoxifen should be discussed for women age 35 and older at increased risk of breast cancer. Tamoxifen cuts second cancer risk in BRCA carriers 2013-08-16T15:47:34Z Researchers suggested that taking tamoxifen for a longer period may help, but they said the underlying problem was that trials needed to involve more younger patients. Breast cancer trials 'failing young' 2013-05-31T23:18:11Z There are the few therapies, he said — like tamoxifen and Herceptin — that target specific tumor characteristics, and newer tests that estimate the chance of recurrence in estrogen-positive cancers, allowing lower-risk women to skip chemotherapy. Our Feel-Good War on Breast Cancer 2013-04-27T01:21:08Z Women over 50 were more likely to develop blood clots from the drugs, or uterine cancer while taking tamoxifen. Breast Cancer Drugs Urged for Healthy High-Risk Women 2013-04-15T21:00:35Z The British researchers said they observed no excess incidence of stroke with 10 years of tamoxifen therapy, although the endometrial cancer risk was higher. Longer use of tamoxifen shown to cut risk of breast cancer recurrence 2013-06-02T11:37:37Z Women with the BRCA1 mutation were 62 percent less likely to develop a second cancer if they took tamoxifen, while BRCA2 carriers had a 67 percent lower risk with the drug. Tamoxifen cuts second cancer risk in BRCA carriers 2013-08-16T15:47:34Z This form of the disease is usually treated by chemotherapy followed by the drug tamoxifen for five years to block oestrogen receptors. Breast cancer trials 'failing young' 2013-05-31T23:18:11Z I was also prescribed tamoxifen to cut my risk of metastatic disease from 20 percent to 12. Our Feel-Good War on Breast Cancer 2013-04-27T01:21:08Z Other doctor groups, including the American Society of Clinical Oncology, also recommend some women at high risk of breast cancer be offered tamoxifen or raloxifene. Discuss cancer-reducing drugs with women - panel 2013-04-15T21:06:30Z They estimated that for every endometrial cancer death that occurs as a side effect of long-term tamoxifen, 30 deaths from breast cancer would be prevented. Longer use of tamoxifen shown to cut risk of breast cancer recurrence 2013-06-02T11:37:37Z Women with these hormone-responsive cancers are typically prescribed tamoxifen, which blocks estrogen and reduces their risk of cancer recurrence by 40 percent. Tamoxifen cuts second cancer risk in BRCA carriers 2013-08-16T15:47:34Z "The biggest surprise was the presence of tamoxifen, a synthetic hormone used in the treatment of breast cancer," wrote the magazine. One in five French bottled waters contain 'drugs or pesticides' 2013-03-25T16:35:42Z The tamoxifen would lower my risk of future disease to that of an average woman, he said. Our Feel-Good War on Breast Cancer 2013-04-27T01:21:08Z Both drugs also doubled the risk of blood clots and tamoxifen increased the chance of endometrial cancer and cataracts, according to findings published in the Annals of Internal Medicine. Discuss cancer-reducing drugs with women - panel 2013-04-15T21:06:30Z The next step in his treatment is a modified radical mastectomy, then radiation and five years of tamoxifen, which inhibits estrogen from stimulating the grown of breast cancer cells. Because male breast cancer is rare, many cases aren’t caught till later stages 2013-02-25T23:41:37Z Currently, both tamoxifen and raloxifene, a similar breast cancer drug, are not licensed for this indication in the UK, although they are in some other countries. 'Historic' breast cancer drug move 2013-01-15T03:54:34Z Currently, both tamoxifen and raloxifene, a similar breast cancer drug, are not licensed for this indication. 'Historic' breast cancer drug move 2013-01-15T03:54:34Z Emily Behrend, who is a few months from finishing her five years on tamoxifen, said she would consider another five years. Longer tamoxifen use cuts breast-cancer deaths, study says 2012-12-06T00:54:04Z In absolute terms, continuing on tamoxifen kept three additional women out of every 100 from dying of breast cancer within five to 14 years from when their disease was diagnosed. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z “Over all, the benefits of extended tamoxifen seemed to outweigh the risks substantially,” Trevor J. Powles of the Cancer Center London, said in a commentary published by The Lancet. Extended Use of Breast Cancer Drug Suggested 2012-12-05T14:58:28Z An international group of scientists, led by Dr Christina Davies from the University of Oxford, looked at the effect of sustained tamoxifen on the likelihood that cancer would return. Breast drug time 'should double' 2012-12-05T13:32:47Z By guiding evolution's natural resistance mechanism, the cancers that emerged were oestrogen dependent — and were thus treatable with oestrogen-dependent cancer drugs, such as tamoxifen. Mathematical modelling: Forecasting cancer 2012-11-23T15:21:12.853Z "Overall, the benefits of extended tamoxifen seemed to outweigh the risks substantially," Trevor Powles, of the Cancer Center London, said in a commentary published by The Lancet. Longer tamoxifen use cuts breast-cancer deaths, study says 2012-12-06T00:54:04Z When added to the benefit from the first five years of use, a decade of tamoxifen can cut breast cancer mortality in half during the second decade after diagnosis, researchers estimate. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z Extended Use of Breast Cancer Drug Is Suggested The widely prescribed drug tamoxifen already plays a major role in reducing the risk of death from breast cancer. Extended Use of Breast Cancer Drug Suggested 2012-12-05T14:58:28Z The results found that cancer returned in a quarter of the women given five years of tamoxifen. Breast drug time 'should double' 2012-12-05T13:32:47Z It was orders of magnitude more expensive than the old standby tamoxifen for only a slight advantage in efficacy.” Why Sanofi's Zaltrap Deal Won t Help Patients 2012-11-19T15:15:00.417Z The widely prescribed drug tamoxifen plays a major role in reducing the risk of death from breast cancer. Longer tamoxifen use cuts breast-cancer deaths, study says 2012-12-06T00:54:04Z Even some women past menopause choose tamoxifen over the newer drugs, which cost more and have different side effects such as joint pain, bone loss and sexual problems. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z Drugs such as tamoxifen, discovered decades ago, provided genuine breakthroughs in cancer care unlike the latest generation of medicines, experts said. Cancer fight stalls amid push for profits, doctors say 2012-10-28T19:12:27Z When tamoxifen levels grow high enough to occupy most of the available oestrogen receptors, the effect reverses and the drug begins to inhibit the cancer cells' growth. Toxicology: The learning curve 2012-10-24T17:20:39.163Z In contrast, less than one-third of women on tamoxifen, another anti-estrogen drug, reported painful sex. Sex problems common with breast cancer drugs 2012-09-28T19:27:13Z It is newer and somewhat more effective than tamoxifen, a medicine long used to prevent cancer's return, but it is also more expensive. Cancer's growing burden: the high cost of care 2012-02-25T19:16:04Z The new study aimed to see whether over a very long time, longer treatment with tamoxifen could help. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z While two other drugs, tamoxifen and raloxifene, are already approved to prevent breast cancer, they are rarely used for that purpose, in part because of serious side effects like blood clots. Exemestane, Thought to Prevent Cancer, Also Causes Bone Loss 2012-02-06T23:37:49Z The drug letrozole reduces the chances that a woman’s cancer will return and improves her odds of survival to a greater degree than tamoxifen, a widely used estrogen blocker, according to a new analysis. Vital Signs: Letrozole Surpasses Tamoxifen at Reducing Breast Cancer Recurrence 2011-10-24T16:08:18Z For the new study, researchers surveyed 82 women who'd had breast cancer and were taking aromatase inhibitors or tamoxifen to prevent the cancer from coming back. Sex problems common with breast cancer drugs 2012-09-28T19:27:13Z Some women took tamoxifen, a hormone-blocking drug given to women whose tumors may be fed by estrogen. Study Finds Benefit to Radiation After Breast Cancer Surgery 2011-10-19T23:53:17Z But beyond that time, 15 percent of women who had stopped taking tamoxifen after five years had died of breast cancer versus 12 percent of those who took it for 10 years. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z She and her colleagues speculate that tamoxifen may boost diabetes risk in women already predisposed to the disease. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z "This is a new option for prevention of invasive breast cancer for a wide pool of women," without the serious side effects of tamoxifen or raloxifene, Goss said. Hormone-blocking drug reduces breast cancer risk 2011-06-04T22:31:06Z Both tamoxifen and raloxifene, sold as Evista, are approved to prevent breast cancer but are not used much for that purpose. Popular Drug Stalls Ovarian Cancer, Studies Say 2011-06-04T16:30:34Z The drug is also used to treat women whose breast cancer worsened while they were taking tamoxifen. Aromasin cuts risk of breast cancer in some groups 2011-06-04T15:31:58Z But it rarely proved fatal, and there was no increased risk among premenopausal women in the study - the very group tamoxifen helps most. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z However, the agency says, the benefits of tamoxifen in treating breast cancer are "firmly established and far outweigh the potential risks." Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z Two drugs, tamoxifen and raloxifene, may also be able to reduce the risk. MRI finds earlier breast cancers in gene carriers 2011-04-05T17:16:10Z He estimates that for every 1000 women given tamoxifen there would be 20 fewer breast cancers, but there would also be three more womb cancers and six more cases of deep vein thrombosis. Drugs 'can prevent breast cancer' 2011-03-27T23:54:37Z Its side effects were much milder that those seen with tamoxifen, he said, although there was a slight increase in osteopenia -- low bone density, but not low enough to be classified as osteoporosis. Aromasin cuts risk of breast cancer in some groups 2011-06-04T15:31:58Z "Overall the benefits of extended tamoxifen seemed to outweigh the risks substantially," Dr. Trevor Powles of the Cancer Centre London wrote in an editorial published with the study. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z But researchers say it is plausible that in women with known risk factors for diabetes -- like obesity or family history of the disease -- tamoxifen furthers the risk somewhat. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z The have shown that tamoxifen reduces the risk of the most common kind of breast cancer by about a third in more vulnerable women. Newspaper review 2011-03-28T05:45:47Z Increased breast density is one of the leading risk factors for breast cancer and early trial results suggest that where tamoxifen is shown to decrease density, the risk of cancer decreases. Drugs 'can prevent breast cancer' 2011-03-27T23:54:37Z The study also shows that women taking tamoxifen for a longer period may reduce heart disease, at least among women in their 50s. Five years on breast cancer drug tamoxifen beats two 2011-03-25T21:42:38Z Previous studies found that starting on one of the newer hormone blockers led to fewer relapses than initial treatment with tamoxifen did. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z Those odds were one quarter higher among women who were currently on tamoxifen, versus those who were not. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z And now the first large study to look at the long-term benefits of long-term tamoxifen shows taking the drug for the full five years boosts survival substantially. 'Stay on tamoxifen' women told 2011-03-22T03:49:28Z But this trial is the first large study to compare long-term benefit of five years of tamoxifen versus two, over a 10-year follow-up period. Long-term tamoxifen boosts breast cancer survival 2011-03-21T21:16:19Z Conclude the researchers: "Women should be encouraged to continue with their adjuvant tamoxifen therapy for the current recommended target duration of 5 years." Five years on breast cancer drug tamoxifen beats two 2011-03-25T21:42:38Z Women in his study have not been followed long enough to see whether switching cuts deaths from breast cancer, as 10 years of tamoxifen did. Longer tamoxifen use cuts breast cancer deaths 2012-12-05T14:26:36Z Along with treating cancer, tamoxifen is sometimes prescribed to lower breast cancer risk in women at higher-than-average risk of the disease. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z Our study provides conclusive evidence that taking tamoxifen for five years offers women the best chance of surviving breast cancer. 'Stay on tamoxifen' women told 2011-03-22T03:49:28Z Experts in the United States estimate that five years of tamoxifen would cost around $8,500, compared with $50,000 to more than $200,000 for chemotherapy to treat breast cancer. Long-term tamoxifen boosts breast cancer survival 2011-03-21T21:16:19Z After 2 years of daily tamoxifen treatment, nearly 3,500 participants were randomly assigned to either stay with the drug for another 3 years or stop taking it. Five years on breast cancer drug tamoxifen beats two 2011-03-25T21:42:38Z Patients are usually treated with chemotherapy because the cancer does not respond to hormone-based drugs like tamoxifen, or drugs that target epidermal growth factors like Herceptin. Sanofi-Aventis says cancer drug has little effect 2011-01-28T15:55:59Z That increase is small and the findings should not "alarm" women taking tamoxifen, said study leader Lorraine L. Lipscombe, of Women's College Hospital and the University of Toronto in Canada. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z It's vital that doctors and nurses continue encouraging women to finish their course of tamoxifen and providing the necessary support to ensure any side-effects are effectively managed. 'Stay on tamoxifen' women told 2011-03-22T03:49:28Z Side effects such as aching joints and weak bones seem to be more common than with tamoxifen. Consumer Reports Insights: Treatment options for women with breast cancer 2011-01-24T21:04:02Z After 15 years, there were seven fewer heart attacks and strokes per 100 women taking tamoxifen for 5 years compared to 2, and three fewer deaths from those diseases. Five years on breast cancer drug tamoxifen beats two 2011-03-25T21:42:38Z More research is needed, they caution, before tamoxifen will be prescribed solely for the purpose of preventing death from lung cancer. Anti-estrogens linked to fewer lung cancer deaths 2011-01-24T18:16:18Z And if tamoxifen does affect the odds of developing diabetes, it may only do so in certain women, according to Lipscombe. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z Some of these drugs, including raloxifene and tamoxifen, are primarily used to treat breast cancer after menopause. Some osteoporosis patients take drug "holiday" 2010-11-15T05:16:00Z Aromatase inhibitors, a newer class of drugs, cause fewer problems than tamoxifen. Consumer Reports Insights: Treatment options for women with breast cancer 2011-01-24T21:04:02Z After Trandel completes two years of tamoxifen, she will try to get pregnant. Fertility and Cancer: Surviving and Having Kids Too 2010-10-20T00:20:00Z Bouchardy and her colleagues then calculated the chances of getting lung cancer and of dying from it in women who took tamoxifen and those who didn't. Anti-estrogens linked to fewer lung cancer deaths 2011-01-24T18:16:18Z If tamoxifen does increase the risk of diabetes, it would not be the only side effect of the drug. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z They said most breast cancer patients past menopause should consider taking an aromatase inhibitor at some point, either right after surgery or after two to three years of the drug tamoxifen. U.S. cancer group endorses newer breast cancer drugs 2010-07-12T20:24:00Z Because paroxetine and fluoxetine inhibit an enzyme needed to metabolize tamoxifen, women on the drug cannot use those antidepressants for hot flashes. Antidepressant cools hot flashes in study 2010-06-03T17:22:00Z That’s 42 possibly lethal things, twice as many as the bad things reduced by tamoxifen. When Lowering the Odds of Cancer Isn't Enough 2009-12-14T22:09:00Z Uterine cancer developed in 65 tamoxifen users but in only 37 women on Evista. Study: 2 good choices to prevent breast cancer 2010-04-19T15:27:00Z The findings, reported in the journal Cancer, do not prove that tamoxifen directly leads to diabetes in some women. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z Doctors can already also test for certain genes to tell whether a woman's breast cancer is sensitive to estrogen and likely to benefit from hormone-blocking drugs like tamoxifen. Gene test helps select breast cancer chemotherapy 2010-03-25T17:18:00Z And as with hormone replacement, phytoestrogens would not be recommended for women with a history of breast cancer or an increased risk of the disease, which includes women on tamoxifen. Antidepressant cools hot flashes in study 2010-06-03T17:22:00Z There are 5 randomized prevention trials comparing tamoxifen with placebo for the reduction of breast cancer risk. When Lowering the Odds of Cancer Isn't Enough 2009-12-14T22:09:00Z She switched to Evista after two years on tamoxifen because of worries about side effects. Study: 2 good choices to prevent breast cancer 2010-04-19T15:27:00Z Nor did the researchers see a connection between diabetes and another class of breast cancer drugs called aromatase inhibitors -- which also inhibit estrogen, though by a different mechanism than tamoxifen. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z Women who took GlaxoSmithKline's Paxil while taking tamoxifen at the same time were more likely to die of their breast cancer, the researchers found. 2010-02-09T00:04:00Z In 2000, Freedman and his colleagues estimate, 120,737 U.S. women between the ages of 40 and 79 were using tamoxifen to cut their risk of breast cancer. 2010-02-08T22:15:00Z Will the manufacturers and medical promoters of taking tamoxifen preventively be handsomely compensating all victims of such egregious side effects? When Lowering the Odds of Cancer Isn't Enough 2009-12-14T22:09:00Z Prior to this acquisition, clients relied on Medco's personalized medicine programs for information on testing for appropriate use of just a few drugs, such as the blood thinner warfarin and the breast cancer medicine tamoxifen. 2010-02-02T06:05:00Z Still, this is the first study to show a link between tamoxifen and diabetes. Breast cancer drug tied to diabetes in older women 2011-10-06T17:27:26Z The longer the overlap between Paxil and tamoxifen, the more likely the patients were to die, they reported in the British Medical Journal. 2010-02-09T00:04:00Z It would be worthwhile, Freedman said, for future studies to delve into the reasons for the relatively low rate of tamoxifen use. 2010-02-08T22:15:00Z It suggests that our lack of enthusiasm for tamoxifen poses some psychological mystery to unravel, while the side effects aren’t mentioned for a good 12 paragraphs. When Lowering the Odds of Cancer Isn't Enough 2009-12-14T22:09:00Z About 30 percent of the patients also took an antidepressant at some time during their treatment with tamoxifen, and paroxetine was the most common one. 2010-02-09T00:04:00Z This rose to a 91 percent risk for the women who took tamoxifen and Paxil together for 75 percent of the time. 2010-02-09T00:04:00Z It is likely because Paxil, sold generically as paroxetine, interferes with the compound the body uses to process tamoxifen, the researchers said. 2010-02-09T00:04:00Z In 2005, government researchers found, about 51,500 U.S. women were using tamoxifen in order to lower their risk of breast cancer. 2010-02-08T22:15:00Z I’m certainly not condemning women for making this choice — just reporting on the fact that they clearly are making the choice not to use tamoxifen. When Lowering the Odds of Cancer Isn't Enough 2009-12-14T22:09:00Z For the body to use it, tamoxifen must be broken down by an enzyme called CYP2D6. 2010-02-09T00:04:00Z However, the trial also revealed a number of risks, including heightened rates of endometrial cancer, blood clots and cataracts among tamoxifen users. 2010-02-08T22:15:00Z "It is easy for women on tamoxifen to become alarmed by the results of this study," Juurlink added in a telephone interview. 2010-02-09T00:04:00Z "This study really just describes how many women are using tamoxifen" to prevent breast cancer, Freedman said. 2010-02-08T22:15:00Z For example, over seven years of follow-up, 53 women in the tamoxifen group developed endometrial cancer, versus 17 women in the placebo group. 2010-02-08T22:15:00Z And 28 tamoxifen users developed a blood clot in the lungs, compared with 13 cases in the placebo group. 2010-02-08T22:15:00Z Like tamoxifen, it blocks estrogen activity in breast tissue, and studies so far indicate that the two drugs are similarly effective at reducing breast cancer risk. 2010-02-08T22:15:00Z |
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