Those antibodies also activate the complement pathway which leads to muscle cell destruction.

这些抗体也会激活补体通路，破坏肌肉细胞。

When the abnormal IgA1-IgG immune complexes deposit in the mesangium, the alternative complement pathway is activated, leading to the release of proinflammatory cytokines and migration of macrophages into the kidney, all of which contributes to glomerular injury.

当异常的IgA1-IgG免疫复合物沉积在系膜上时，补体旁路途径被激活，导致促炎因子的释放，同时促进巨噬细胞向肾迁移，以上所有反应会导致肾小球的损伤。