Some holoenzymes, such as pyruvate dehydrogenase, are highly compex, with several cofactors.

有一些全酶是高度复杂的，如丙酮酸脱氢酶。

An enzyme without its cofactor is termed an apoenzyme.

没有辅助因子的酶叫做脱辅酶。

A cofactor bound loosely to the apoenzyme and readily separable from it is a coenzyme.

与脱辅基蛋白结合松弛、易于与之分离的辅基因子称为辅。

When a catalytically active enzyme forms a complex with a cofactor a holoenzyme is produced.

酶蛋白和辅助因子两者结合成完整分子时，形成具有活力的全酶。

Methylmalonic acidemia is an inherited metabolic disorder,which is caused by deficiency of methylmalonyl-coenzyme A mutase or its cofactor adenosylcobalamin.

甲基丙二酸血症是由于甲基丙二酰辅酶A变位酶或其辅酶腺苷钴胺素缺陷所致的一种遗传性代谢疾病。