Interestingly, one of the most effective antipsychotic drugs, clozapine, is a weak D2 antagonist, suggesting that other neurotransmitter systems like norepinephrine, serotonin, and GABA are involved.

有趣的是，最有效的抗精神病药之一，氯氮平，是一种弱D2受体拮抗剂；这提示其它神经递质系统，比如去甲肾上腺素、5-羟色胺、γ-氨基丁酸也与疾病有关。