Specifically, the beta-globin chains end up misshapen, and this is because of a mutation in the beta-globin gene or HBB gene.

确切来说，（该病中）β-珠蛋白链发生变形，而这是由β-珠蛋白基因（HBB基因）的突变造成的。

Once the chain reaches the second guardian, the process is repeated, creating a chain ending at the remaining guardian.

一旦链条到达第二个守护者，就会重复这个过程，创建一个链条，以剩下的守护者结束。

We need to have the courage to orchestrate the reinvention of the entire value chain, end to end, and we need to have massive collaboration to get it done in time.

我们需要有勇气协调整个价值链端到端的重塑，我们需要进行大规模的合作才能及时完成任务。