That's because it has even been associated with shortened telomeres, the shoelace tip ends of chromosomes that measure a cell's age.

因为它甚至会令你的染色体终端变短，而染色体的这个端粒恰恰影响着细胞的寿命。

You know, we were right at tip end of the arctic, tough conditions, he was in at the deep end in every way.

你知道，我们正处于北极的顶端，恶劣的条件下，他在各方面都处于最深处。