Actually, my, you know, my grandfather, he's set in his ways, he can't change.

事实上，我的祖父，他已经习惯了他的生活方式，他无法改变。

I think he has opinions and he's set in his way, but I think he's also open for discussion.

我认为他有自己的意见， 而且他已经确定了自己的方式， 但我认为他也愿意进行讨论。

Good. And remember the pronoun will change. So, " he is set in his ways" , " I am set in my ways" , right?

记住，代词是会改变的。所以，" he is set in his ways" ， " I am set in my ways" 。