Often there are also systemic symptom like fatigue and fever.

通常还有全身症状，如疲劳和发烧。

These systemic symptoms are what often distinguish acute pyelonephritis from a lower urinary tract infection.

这些全身症状常可用来区分急性肾盂肾炎和下尿路感染。

The infection causes systemic symptoms like fevers and flank pain at the costvertebral angle and is treated with antibiotics.

急性肾盂肾炎感染导致全身症状，如发热、肋脊角痛；可使用抗生素治疗。