Which may be one reason why SSRI medications typically take so long to work.

这也许是 SSRI 药物通常需要很长时间才能起作用的一个原因。

SSRI's help regulate serotonin levels in the brain, while SNRIs help regulate serotonin, norepinephrine and dopamine, to manage anxiety.

SSRIs帮助调节大脑中5-羟色胺的水平，而SNRIs帮助调节5-羟色胺、去甲肾上腺素和多巴胺水平，以调节焦虑。

Even though serotonin concentrations may go up right away when you take an SSRI, it can still take weeks for people to start feeling better.

即使服用 SSRI 后 5-羟色胺浓度可能会立即升高，但仍然需要数周时间才能让患者感觉有所好转。

Most SSRIs are off-patent and therefore cheap.

大多数 SSRI 都没有专利，因此价格便宜。

If that were true, you'd expect that SSRI medications to work pretty quickly, and to work for everyone with depression — but they don't.

如果这是真的，你会期望 SSRI 药物能很快发挥作用，并且对每个抑郁症患者都有效，但其实并不是这样。

However, this belief in the ease of ending SSRI treatment was based on studies in which the patients had been on it for just a few weeks.

然而，这种认为结束 SSRI 治疗很容易的信念是基于对患者仅服用几周的研究。

It was the first of a new class of drugs called Selective Serotonin Reuptake Inhibitors, or SSRI's, which block the reabsorption of serotonin, leaving more available in the brain.

它是称为选择性 5- 羟色胺再摄取抑制剂或 SSRI 的新型药物中的第一种， 它可以阻止 5-羟色胺的再吸收， 从而在大脑中留下更多可用药物。

At the moment, drug choice works by trial and error, with the initial SSRI being selected more or less at random and a replacement chosen a few weeks later if it does not do the business.

目前，药物选择是通过反复试验来进行的，最初的 SSRI 或多或少是随机选择的， 如果它不起作用， 则在几周后选择替代品。

In other words, reducing SSRIs more slowly at lower doses is needed to produce a gradual decline in their effect—and thus minimise withdrawal symptoms.That led to the idea of stepped reductions which now bears their joint names.

换句话说，需要以较低剂量更缓慢地减少 SSRIs，以逐渐降低其效果，从而最大限度地减少戒断症状。这导致了逐步减少的想法，现在以它们的名字命名。

A study published in 2010, which examined research on two common SSRIs, estimated that for people with less severe depression the odds of improving by taking the drugs were just 6% higher than they were for taking a placebo.

2010 年发表的一项研究考察了两种常见 SSRI 的研究，估计对于抑郁症较轻的人来说，通过服用这些药物改善抑郁症的几率仅比服用安慰剂的人高 6%。