And when tumor suppressor genes, like the genes that encode proteins p53, p16, and the retinoblastoma protein, also called pRb, are inactivated, it removes the inhibition to cell division.

当抑癌基因（如编码蛋白质的p53基因、p16基因、成视网膜母细胞瘤蛋白或称pRb基因）失活时，抑制细胞分裂的机制就被去除了。