Profound significance for human exploration of space.

对人类探索太空具有深远意义。

This change was of profound significance.

这一变化意义深远。

Odysseus building his home is man performing a supreme act of piety; through all the ages that picture must retain its profound significance.

奥德修斯建造自己的家园是一个表现出至高无上的虔诚行为的人； 历经所有时代， 这幅画必须保持其深远的意义。

One netizen commented on Weibo: " It's not one of those films where fans are just promoting it for box office numbers. It's going to have a lasting social impact and profound significance."

一位网友在微博上评论道：“这不是影迷们为了票房而宣传的电影。它将产生持久的社会影响和深远的意义。”