Worsening of anxiety and depression was particularly common in the placebo group at 12 to 16 weeks—a finding that can guide doctors and patients on how to plan the timing of tapering the drugs.

焦虑和抑郁的恶化在 12 至 16 周时在安慰剂组中尤为常见——这一发现可以指导医生和患者如何计划逐渐减少药物的时间。